journal
Journals Journal of Physiology and Phar...

Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society

https://read.qxmd.com/read/37865963/the-formation-of-complexes-with-albumin-increases-the-stability-of-the-protoporphyrin-ix-spectra
#21
JOURNAL ARTICLE
L Sulkowski, A Matyja, C Osuch, M Matyja
Photodynamic therapy is a high-target, low-invasive treatment utilized to manage a variety of malignant diseases and precancerous lesions. Protoporphyrin IX (PpIX) is one of the most important photosensitizers used in photodynamic therapy, carried to the cancer tissue by serum albumin. Its delivery by transport protein is one of the major factors in determining the efficacy of photodynamic therapy. The distribution of the albumin-PpIX complexes to the target tissue enables the accomplishment of an optimal PDT effect...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865962/histopatological-parameters-of-the-spinal-cord-in-different-phases-of-experimental-autoimmune-encephalomyelitis-a-mouse-model-of-multiple-sclerosis-examined-by-classical-stainings-combined-with-immunohistochemistry
#22
JOURNAL ARTICLE
G Pyka-Fosciak, M Fosciak, B Wojcik, G J Lis, J A Litwin
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE) are characterized by three main histopathological parameters: inflammation, demyelination and axonal damage. In this study, these parameters were assessed in spinal cords of mice in the successive phases of EAE by quantitative histology and immunohistochemistry. The number of inflammatory lesions, the intensity of inflammation and expression of CD45 corresponded with the severity of clinical symptoms: they increased from the onset phase to the peak phase of the disease and subsided in the chronic phase...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865961/healing-effect-of-warfarin-in-the-course-of-cerulein-induced-acute-pancreatitis-in-rats
#23
JOURNAL ARTICLE
K Konarska-Bajda, P Ceranowicz, J Cieszkowski, G Ginter, A Chmura, A Stempniewicz, K Galazka, B Kusmierz-Cabala, P Dumnicka, J Bonior, M Sporek, T Brzozowski, Z Warzecha
Acute pancreatitis (AP) is the most common gastrointestinal disease leading to hospitalizations and unexpected deaths. The development of AP leads to damage of the pancreatic microcirculation with a cascade of subsequent events resulting, among others, in coagulopathy. Previous research showed that anticoagulants can be important therapeutic agents. Heparin and acenocoumarol can alleviate the course of AP, as well as accelerate healing and post-inflammatory regeneration of the pancreas. The aim of this study was to determine whether warfarin, a drug with more stable effects than acenocoumarol, affects the healing and regeneration of the pancreas in the cerulein-induced AP...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865960/promotion-of-hepatic-stellate-cell-activation-and-liver-fibrosis-by-microrna-33a-5p-through-targeting-the-dickkopf-1-mediated-wingless-related-integration-site-beta-catenin-pathway
#24
JOURNAL ARTICLE
H Liu, S Zhang, Z Li, Z Zheng, W Shi, M Hu, F Liu
Liver fibrosis occurs in response to chronic liver injury and is characterized by the production of excess extracellular matrix (ECM) proteins, largely by activated hepatic stellate cells (HSCs). Numerous studies have implicated micro-ribonucleic acids (miRNAs) in liver fibrosis, but the mechanisms remain unclear. Herein, HSC activation by miR-33a-5p during hepatic fibrosis was investigated. The miR-33a-5p was increased in the fibrotic mice and activated HSCs. AntagomiR-33a-5p inhibited HSC activation, proliferation, and migration in vitro, while simultaneously inducing apoptosis...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865959/ostarine-does-not-enhance-the-metabolic-effect-of-exercise-in-obese-rats
#25
JOURNAL ARTICLE
N Leciejewska, E Pruszynska-Oszmalek, M Sassek, M Głowacki, T Lehmenn, A Rekas-Dudziak, L Nogowski, K W Nowak, P A Kolodziejski
Overweight and obesity are associated with severe metabolic disorders and an increased risk of cardiovascular diseases. It is a known fact that physical activity has a positive effect on metabolic parameters, and also reduces the risk of diseases such as diabetes. Some products can enhance the rate of lipolysis and help in improving fat loss. One of these are selective androgen receptor modulators (SARMs) which act as anabolic agents and are also believed to aid in fat-burning. In this study, we investigated whether 30 days of ostarine administration could potentially improve metabolic parameters using the rat model of obesity combined with exercise...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865958/regulatory-effects-of-baicalin-a-flavonoid-compound-on-adipocyte-metabolism
#26
JOURNAL ARTICLE
T Szkudelski, K Konieczna, K Szkudelska
Baicalin is a plant-derived, biologically active compound exerting numerous advantageous effects. Adipocytes store and release energy in the process of lipogenesis and lipolysis. Rodent studies have shown that baicalin treatment positively affects fat tissue, however, data on the direct influence of this compound on adipocyte metabolism is lacking. In the present research, the short-term effects of 25, 50, and 100 μM baicalin on glucose transport, conversion to lipids, and oxidation, and also on lipolysis in primary rat adipocytes were explored...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865957/effect-of-emodin-combined-with-cisplatin-on-the-invasion-and-migration-of-hepg2-hepatoma-cells
#27
JOURNAL ARTICLE
M Yang, Z Xiong, H Deng, X Chen, Q Lai, H Wang, Y Leng
Cisplatin is the leading chemotherapy agent for advanced liver cancer. However, the resistance to cisplatin in liver cancer reduces its efficacy. A potential strategy to increase its effectiveness and reduce toxicity is to combine cisplatin with 1,3,8-trihydroxy-6-methylanthraquinone (emodin). In this study, we examined the effects of emodin combined with cisplatin on the invasion and migration of HepG2 cells and analyzed the role of emodin. The effects of cisplatin, emodin and their combination were assessed in HepG2 cells...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865956/acute-daily-exposure-to-ambient-air-pollution-impairs-endothelium-dependent-vasodilator-responses-in-young-healthy-individuals
#28
JOURNAL ARTICLE
B Jasiewicz-Honkisz, G Osmenda, G Wilk, K Urbanski, K Luc, B Guzik, T P Mikołajczyk, T J Guzik
Exposure to ambient air pollution influences cardiovascular (CV) morbidity and mortality. The differential effects of changing particulate or gaseous air pollution on endothelial function in young healthy individuals remain unclear. The aim of this study was to evaluate the relationships between exposures to different pollutants and vascular function in a group of 39 young (33±11 years old) subjects with low CV risk. Flow-mediated dilatation (FMD) and nitroglycerin-mediated dilatation (NMD) were performed, when air pollution reached highest levels (heating period) and repeated in a subgroup of 18 participants a few months later (just before the heating period starts)...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865955/melatonin-attenuates-inflammation-and-cardiac-dysfunction-in-myocardial-infarction-by-regulating-the-mirna-200b-3p-high-mobility-group-box-chromosomal-protein-1-axis
#29
JOURNAL ARTICLE
Z H Liu, F Wu, K Ren, J L Huo
Melatonin confers protection against myocardial injury by reducing inflammation and inhibiting apoptosis. In the present study, we investigated whether melatonin regulates cardiomyocyte proliferation and improves cardiac function in rats with myocardial infarction (MI). Two MI models were established in vitro (H9c2 cells were cultured under hypoxia) and in vivo (the left anterior descending coronary artery of rats was surgically ligated). miR-200b-3p and high mobility group box 1 (HMGB1) levels were detected...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37865954/advances-in-non-pharmacological-management-of-parkinson-s-disease-complicated-with-blood-pressure-abnormalities
#30
REVIEW
Q Xing, X Zhao, L Xie, X Chen, Y Wang, Y Xie
Parkinson's disease (PD) often presents with autonomic dysregulation, leading to blood pressure irregularities such as neurogenic orthostatic hypotension (nOH), neurogenic supine hypertension (nSH), and postprandial hypotension (PPH). Unfortunately, these conditions remain prevalent and receive insufficient attention in scientific discourse. They not only cause complications like syncope, falls, and fractures but also result in long-term damage to vital organs, diminishing patients' quality of life. Early implementation of appropriate non-pharmacologic management is crucial to prevent severe adverse events later on...
August 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661187/connexin-43-gap-junction-affects-survival-and-drug-resistance-of-multiple-myeloma-side-population-cells
#31
JOURNAL ARTICLE
Z Wang, J X Fu, X H Zhang, Y Sun, X P Ge
Drug resistance remains a major challenge for multiple myeloma (MM) treatment, and side population (SP) cells may play a key role in this resistance. The function of connexin 43 (Cx43)-mediated gap junction intercellular communication (GJ-IC) in MM cells is poorly understood. Bone marrow mesenchymal stem cells (BMSCs) from different sources were isolated and cultured. SP cells of MM cell line RPMI 8266 were separated by flow cytometry. Real-time reverse transcriptase-polymerase chain reaction and Western blot were used to detect Cx43 mRNA and protein expression in BMSCs, RPMI 8266 and SP cells from different sources...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661186/hyperbaric-oxygen-ameliorates-neuronal-injury-and-neurological-function-recovery-in-rats-with-intracerebral-hemorrhage-by-silencing-microrna-204-5p-targeted-chloride-channel-protein-3
#32
JOURNAL ARTICLE
B Q Wang, M He, Y Wang, S Liu, Z W Guo, Z L Liu
Hyperbaric oxygen (HBO) therapy is of clinical utility in patients with transient cerebral ischemia. The investigatory study was to identify the potential regulatory mechanism of HBO treatment on neuronal injury and neurological function recovery in rats with intracerebral hemorrhage (ICH). Firstly, the rat model of ICH was established by collagenase, and the experimental rats were treated with HBO at 2.5 absolute atmospheres for 60 min each time. Next, lentivirus interfering with microRNA (miR)-204-5p or chloride channel protein 3 (CLCN3) expression was injected via the tail vein...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661185/oxidative-stress-responses-and-their-alterations-in-the-nrf2-nmda-receptor-pathway-in-the-brain-of-suicide-victims
#33
JOURNAL ARTICLE
P Panczyszyn-Trzewik, P Misztak, W Opoka, G Nowak, M Sowa-Kucma
Suicide is a global public health concern. There is evidence of an association between suicidal behavior and depressive disorders (DDs). An increasing number of studies have suggested that nuclear factor erythroid-derived 2-like 2 (Nrf2), a major endogenous regulator of the oxidative stress response, can be a novel target for the neurobiology of suicide-related disorders (including depression). This study aimed to investigate the relationship between oxidative stress progression, Nrf2 regulation, and N-methyl-D-aspartate receptor (NMDA) subunit composition in the hippocampus (Hp) and frontal cortex (FCx) of suicide victims (n=14) and matched controls (n=8)...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661184/regulation-of-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-resistance-via-ambra1-mediated-autophagy-in-non-small-cell-lung-cancer
#34
JOURNAL ARTICLE
Y-H Chen, Y Yang, L-J Xu, Y Deng, J-W Fu
To explore the molecular mechanisms related to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) resistance, along with potential therapeutic targets and strategies. The autophagy and Beclin 1 regulator 1 (Ambra1) short hairpin ribonucleic acid (shRNA) lentivirus vector and Ambra1 overexpression plasmid, constructed with a plasmid cloning deoxyribonucleic acid (pcDNA) 3.1 vector, were used to down-regulate and up-regulate Ambra1 expression in the human lung adenocarcinoma erlotinib-resistant cell line (PC9/ER), respectively, as well as to screen stable transgenic cell lines...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661183/isosteviol-attenuates-streptozotocin-mediated-diabetic-nephropathy-in-rats-by-upregulating-and-stimulating-adenosine-monophosphate-activated-protein-kinase
#35
JOURNAL ARTICLE
J Z Altamimi, N A Alfaris, G M Alshammari, R I Alagal, D H Aljabryn, M A Yahya
Diabetic nephropathy (DN) is the major microvascular complication of type 1 diabetes mellitus (T1DM). Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity was shown to mediate the pro-oxidant and inflammatory mechanisms underlying DN. Isosteviol (ISV), isolated from Stevia rebaudiana, has antioxidant and anti-inflammatory properties and alleviates non-alcoholic fatty liver disease and lethal septic shock by activating AMPK. The effect of ISV on DN is unknown. This study examined if ISV alleviates DN in T1DM in adult male rats by activating AMPK...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661182/construction-of-an-autophagy-related-eleven-long-noncoding-rna-signature-to-predict-the-outcomes-immune-cell-infiltration-and-immunotherapy-response-in-patients-with-gastric-cancer
#36
JOURNAL ARTICLE
G C Mu, Y J Luo, J Q Chen
Long noncoding RNAs (LncRNAs) may be involved in the occurrence, development, and drug resistance of gastric cancer (GC) by regulating autophagy. This study aims to establish an autophagy-related LncRNA (ARL) signature (ARLSig) and explore its immunogenomic implications in patients with GC. The RNA sequencing and clinical data of patients with GC from The Cancer Genome Atlas database, and autophagy genes from the Human Autophagy Database were extracted. The co-expression and Cox regression analyses were performed to establish a prognostic ARLSig...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661181/role-of-interferon-alpha-inducible-protein-6-in-modulating-the-proliferation-apoptosis-and-senescence-of-oesophageal-squamous-cell-carcinoma-cells
#37
JOURNAL ARTICLE
Y Gao, J Dai, X P Xu, P F Liu, R H Shi
Oesophageal cancer is one of the most malignant tumors worldwide. Dysfunction of interferon alpha-inducible protein 6 (IFI6) has been implicated in numerous human diseases, including cancer. We performed the study to investigate the function and potential molecular pathways of IFI6 in oesophageal squamous cell carcinoma (ESCC) cells. IFI6 expression was analysed using databases-derived data and paraffin-embedded tissue samples. CCK-8-based analyses and EdU staining, colony formation, β-galactosidase staining and Annexin V/PI double-staining assays were used to determine the influence of IFI6 on cell growth, senescence and apoptosis...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661180/perindopril-and-losartan-attenuate-pro-coagulation-factors-in-human-adipocytes-exposed-to-sars-cov-2-spike-protein
#38
JOURNAL ARTICLE
M Ardiana, I G R Suryawan, H O Hermawan, P M Harsoyo, I M Sufiyah, A R Muhammad, B S I Zaini
Thrombotic events are highly prevalent in coronavirus disease 2019 (COVID-19), especially in patients presenting with risk factors of adverse outcomes such as obesity. Recently, the associations between the angiotensin converting enzyme 2 (ACE2) pathway and thrombosis have been reported. Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) are widely used cardiovascular pharmacologic agents that upregulate ACE2 levels. An observation of the alterations in pro-coagulation factors after exposure to ACEIs and ARBs may provide valuable insight into the thrombosis mechanism and how it may relate to ACE2...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661179/long-term-cryopreservation-of-dental-stem-cells
#39
JOURNAL ARTICLE
R Brozek, B Dorocka-Bobkowska, M Kurpisz
Cryopreservation is a procedure of a long-term storage of cells and/or tissues at a temperature that prevents cell divisions and metabolic processes. Due to ability to self-renewal and differentiation into more specialised cells, stem cells may be helpful in repairing of other damaged organs or tissues. Cryopreservation allows the frozen genetic material to maintain its biological properties for a long time. Therefore, there is a real chance for some samples to be used in the future therapy of the pathological conditions that at present remain incurable because of the current state of knowledge...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/37661178/targeted-therapies-for-glioblastoma-treatment
#40
JOURNAL ARTICLE
A Smolarska, I Pruszynska, W Wasylko, K Godlewska, M Markowska, A Rybak, J Botther, P Kucharzewska, J Nowakowska, J Szeliga, M Kubiak, M Gorczak, M Krol
Glioblastoma, the most common and aggressive type of brain tumor in adults, poses significant challenges in terms of treatment. Conventional approaches including surgery, chemotherapy, and radiotherapy have yielded limited success, with a median survival of approximately 15 months. However, extensive research into the biology of glioblastoma has identified molecular targets that can be exploited by newly developed drugs, leading to the emergence of precise personalized therapies. Several innovative treatment strategies are currently under development, aiming to enhance effectiveness while minimizing side effects...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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