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Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society

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https://www.readbyqxmd.com/read/30415242/clinicopathologic-charcterization-of-sorafenib-induced-endoplasmic-reticulum-stress-in-human-liver-cancer-cells
#1
M Liu, R Zhou, X Wu, X Xu, M Su, B Yang
Sorafenib (Sor) is clinical standard therapy for advanced hepatocellular carcinoma (HCC). However, detailed molecular mechanism behind Sor-exerted pharmacological effect remains unknown. In this study, sera samples, staged hepatic cancer tissues from Sor-treated patients with advanced HCC were harvested for a group of biochemical tests and immunoassays. Compared to non-treated control, blood contents of alanine transaminase (ALT), aspartate transaminase (AST), alphafetoprotein (AFP), fibroblast growth factor 21 (FGF21) were decreased in Sor-treated HCC patients, while the level of interleukin 10 (IL-10) were increased...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415241/beneficial-anti-inflammatory-effect-of-angiotensin-converting-enzyme-inhibitor-and-angiotensin-receptor-blocker-in-the-treatment-of-dextran-sulfate-sodium-induced-colitis-in-mice
#2
H Salmenkari, L Pasanen, J Linden, R Korpela, H Vapaatalo
The renin-angiotensin system (RAS) in the intestine is involved in the regulation of inflammation, apoptosis and tissue fibrosis in experimental models of colitis; the inhibition of local RAS by pharmacologic interventions has been claimed to prevent and alleviate colitis. In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1β) and tumor necrosis factor alpha (Tnf-α) genes...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415240/the-role-of-purinergic-p2y-12-receptor-blockers-on-the-angiogenic-properties-of-endothelial-cells-an-in-vitro-study
#3
K Korybalska, R Rutkowski, J Luczak, N Czepulis, K Karpinski, J Witowski
Pharmacotherapy with agents that inhibit platelet function has proven to be effective in the treatment of acute coronary syndrome. Proper re-endothelization after angioplasty prevents adverse cardiovascular events. Therefore, in this in vitro study we examined how antiplatelet P2Y12 receptor blockers can affect endothelial cells' angiogenic properties. Endothelial cells were exposed to ticagrelor, prasugrel and clopidogrel in their highest concentrations obtained in serum after the treatment with loading and clinical doses...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415239/changes-in-the-vasoactive-effects-of-nitric-oxide-hydrogen-sulfide-and-the-structure-of-the-rat-thoracic-aorta-the-role-of-age-and-essential-hypertension
#4
A Berenyiova, M Drobna, M Cebova, F Kristek, S Cacanyiova
Several studies have already confirmed the specific vasomotor effect of hydrogen sulfide (H2 S) and its interaction with the nitric oxide (NO) system in normotensive rats, but results in spontaneously hypertensive rats (SHRs) are limited. the aim of this study was to describe the age- and blood pressure-dependent effects of endogenous NO and exogenous Na2 S and their interaction in vasomotor responses of the thoracic aorta (TA) in normotensive Wistar rats and SHRs. the systolic blood pressure (sBP), vasoactivity, NO-synthase (NOS) expression and activity, cystathionine gamma-lyase (CSE) expression, and geometry of the isolated TA were evaluated at 4 and 16 weeks of age...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415238/effect-of-thiol-antioxidants-on-lipopolysaccharide-induced-cyclooxygenase-2-expression-in-pulmonary-epithelial-cells
#5
S Choi, J W Lim, H Kim
Cyclooxygenase-2 (COX-2) plays an important role in pulmonary inflammatory response, and its expression is regulated by several transcription factors including nuclear factor kappa-B (NF-κB), activator protein-1 (AP-1), and signal transducer and activator of transcription-3 (STAT-3), which are activated by oxidative stress. Glutathione (GSH) and N-acetyl cysteine (NAC) are thiol antioxidants that scavenge reactive oxygen species (ROS). The present study investigated whether lipopolysaccharide (LPS) induces COX-2 expression through ROS generation and the activation of oxidant-sensitive transcription factors such as NF-κB, AP-1, and STAT-3 in pulmonary epithelial A549 cells...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415237/antioxidant-protection-against-cosmic-radiation-induced-oxidative-stress-at-commercial-flight-altitude
#6
D R Mitrea, H Mortazavi Moshkenani, O A Hoteiuc, C Bidian, A M Toader, S Clichici
It is proposed that at the commercial flight altitude the cosmic radiation affects the human body and induces the oxidative stress. This review presents data to support this idea and also cumulates the information to provide the basis for antioxidant supplementation in persons that travel by plane at high altitudes. The conclusion is that the heterogeneity of cosmic radiation can produce different effects on human body through different mechanisms and the prophylactic treatment with antioxidants can reduce the oxidative stress generated by the radiation exposure...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415236/antithrombotic-medications-and-their-impact-on-fibrin-clot-structure-and-function
#7
A Undas, M Zabczyk
Fibrin constitutes a major protein component of intravascular thrombi in all locations. Fibrin formation and its functions are essential for physiological hemostasis and the pathologic thrombosis. Formation of dense fibrin networks which are relatively resistant to lysis is observed in patients with venous or arterial thromboembolism, including myocardial infarction, ischemic stroke and venous thromboembolism. Measures of clot characteristics, in particular clot permeability and clot lysis time, may predict arterial and venous recurrent thromboembolic events...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30415235/pharmacogenetic-considerations-of-anticoagulant-medication
#8
J Miklosz, B Kalaska, A Mogielnicki
Predicting the clinical consequences of anticoagulant therapy by identifying gene variants could help in the risk assessment of thrombosis or bleeding before and after surgery and may result in choosing more beneficial therapy. This work provides an overview of pharmacogenetic data of commonly used anticoagulant medication. The review focuses on polymorphisms influencing the efficacy and safety of the parenteral and oral anticoagulants. There is evidence that heparin resistance and heparin-induced thrombocytopenia could be genetically determined but it does not mean that the risk of bleeding or thromboembolism is related to mutations in general...
August 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30342432/chronic-stress-changes-prepulse-inhibition-after-amphetamine-challenge-the-role-of-the-dopaminergic-system
#9
M H Lehner, K Karas-Ruszczyk, A Zakrzewska, M Gryz, A Wislowska-Stanek, K Kolosowska, N Chmielewska, A Skorzewska, D Turzynska, A Sobolewska, P Mierzejewski, A Plaznik
The goal of this research was to examine the influence of chronic mild stress (CMS) on prepulse inhibition (PPI). We used an amphetamine challenge to study the role of the dopaminergic system in limbic structures. Chronic stress caused a reduction in both sucrose preference and body weight. It was found that the initially strong response to amphetamine in the control rats was weakened after stress on both the behavioural and biochemical levels: improved PPI, decreased dopamine D2 receptor expression in the central nucleus of amygdala (CeA) and nucleus accumbens (NAC), and decreased dopamine and 3-MT (3-methoxytyramine) levels in NAC...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30342431/gonadotropin-releasing-hormone-and-kisseptin-10-regulate-nuclear-receptor-subfamily-5-group-a-member-1-catenin-beta-1-nuclear-receptor-subfamily-0-group-b-member-1-activity-in-female-rat-anterior-pituitary-gland
#10
M Zielinska-Gorska, K Gorski, K Biernacka, E Sawosy, T Kaminska, A Gajewska
In this study, we tested the hypothesis that modulation of endogenous gonadotropin-releasing hormone (Gnrh) neuronal network activity alters the mRNA expression of nuclear receptor subfamily 5 group A member 1 (Nr5a1), through one of the component of Wnt pathway signaling - catenin beta 1 (Ctnnb1) (its co-activator), and its co-repressor nuclear receptor subfamily 0, group B member 1 (Nr0b1) in the female rat pituitary gland in vivo. Adult ovariectomized rats were given a serial infusion of Gnrh, kisspeptin-10, Gnrh + Gnrh antagonist (Antide), or kisspeptin-10 + kisspeptin antagonist (kisspeptin-234) into the third ventricle of the brain...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30342430/effect-of-corticotropin-releasing-hormone-and-corticotropin-releasing-hormone-nist-on-biosynthesis-of-gonadotropin-relasing-hormone-and-gonadotropin-relasing-hormone-receptor-in-the-hypothalamic-pituitary-unit-of-follicular-phase-ewes-and-contribution-of-kisspeptin
#11
M Ciechanowska, M Kowalczyk, M Lapot, T Malewski, B Antkowiak, M Brytan, I Winnicka, F Przekop
This study aimed to determine the mechanisms governing Gonadotropin releasing hormone (GnRH) biosynthesis and luteinising hormone (LH) secretion in follicular-phase sheep after infusion of corticotropin releasing hormone (CRH) and/or CRH antagonist corticotropin releasing hormone nist (CRH-A) into the third cerebral ventricle. The study included two experimental approaches: first, we investigated the effect of CRH or CRH-A (α-helical CRH 9-41) on GnRH and GnRH receptor (GnRHR) biosynthesis in the preoptic area (POA), anterior (AH) and ventromedial hypothalamus (VMH), stalk/median eminence (SME), and on GnRHR in the anterior pituitary (AP) using an enzyme-linked immunosorbent assay (ELISA); second, we used real-time PCR to analyse the influence of CRH and CRH-A on the levels of kisspeptin (Kiss1) mRNA in POA and VMH including arcuate nucleus (VMH/ARC), and on Kiss1 receptor (Kiss1r) mRNA abundance in POA-hypothalamic structures...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30342429/brain-derived-neutrophic-factor-a-link-of-aerobic-metabolism-to-neuroplasticity
#12
G G De Assis, E V Gasanov, M B C de Sousa, A Kozacz, E Murawska-Cialowicz
Currently, literature has accumulated great knowledge over the effect of exercise on the neurotrophin named brain derived neurotrophic factor (BDNF) and its role in neuronal plasticity. However, there is no enough discussion about how the exercise is related to enrichment of BDNF in specific metabolic properties. This review provides the current evidences regarding aerobic metabolism relation to BDNF concentrations in healthy individuals. A PICOS strategy was applied considering the mesh terms for: P - healthy subjects; I - physical exercise; C - aerobic metabolism demands; O - BDNF concentrations; S - before and after aerobic exercise; on PubMed, Scopus and Medline databases...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279308/an-endogeous-defensive-concept-renewed-cytoprotection-adaptive-cytoprotection-intra-per-oral-intraastric-strong-alcohol-in-rat-involvement-of-pentadecapeptide-bpc-157-and-nitric-oxide-system
#13
T Becejac, V Cesarec, D Drmic, D Hirsl, G Madzarac, Z Djakovic, I Bunjevac, A A Zenko Sever, A Sepac, L Batelja Vuletic, D Stancic Rokotov, S Seiwerth, P Sikiric
With intra(per)-oral strong alcohol application at the tongue, swallowed, we renewed Robert's stomach cytoprotection/adaptive cytoprotection concept. We assessed strong (96%) alcohol-induced severe or minute lesions in stomach, tongue-esophagus-stomach-duodenum lesions, and sphincter pressure (lower esophageal and pyloric) upon administration intragastrically (at 1 h) or intra(per)-orally at the tongue, and swallowed (at 1, 5, 15, 30 min; and 1, 2, 24 h). The assessment also included combined administrations (intra(per)-oral at the tongue, swallowed and intragastric (at 1 h))...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279307/vasodilating-spasmolytic-inotropic-and-chronotropic-activities-of-curcuminoids-from-curcuma-longa-in-isolated-organ-preparations-of-guinea-pigs
#14
Q U A Jamil, S M Iqbal, W Jaeger, C Studenik
Turmeric is a yellowish orange spice, widely used in Asian cuisine and obtained from the rhizome of Curcuma longa. It is a mixture of three curcuminoids namely, curcumin, demethoxycurcumin and bisdemethoxycurcumin. Turmeric has been used as a medicinal substance since ancient times for respiratory and gastrointestinal problems. The aim of the present study was to investigate which curcuminoid contributes to the observed pharmacological activities, all three curcuminoids, the major curcumin metabolite tetrahydrocurcumin, and the non-enzymatic curcumin hydrolysis products ferulic acid, feruloyl methane and vanillin were analyzed for spasmolytic, inotropic and chronotropic activity...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279306/sleep-disturbance-and-disease-activity-in-adult-patients-with-inflammatory-bowel-diseases
#15
A Sobolewska-Wlodarczyk, M Wlodarczyk, J Banasik, A Gasiorowska, M Wisniewska-Jarosinska, J Fichna
The aim of the study was to identify whether poor quality of sleep is connected to inflammatory bowel disease (IBD) and if so, whether sleep disturbances are related to disease activity. Prospective, observational cohort study was performed. In all enrolled adult patients, the disease activity was assessed by using Crohn's Disease Activity Index (CDAI) for Crohn's disease (CD) and Partial Mayo Score for ulcerative colitis (UC), respectively. All patients were also asked to respond to a questionnaire to define Pittsburgh Quality Sleep Index (PSQI)...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279305/hydrogen-sulfide-modulates-gastric-acid-secretion-in-rats-via-involvement-of-substance-p-and-nuclear-factor-%C3%AE%C2%BAb-signaling
#16
H-Z Sun, X-Y Gong, L Wu, X-X Wang, Y-N Nie, R Shang, H Wang, Y-C Li, Q-F Sun, P-F Gao, J-X Bi
Hydrogen sulfide (H2 S) promotes gastric acid secretion in rats. The present study aimed to test the hypothesis that H2 S regulates this response via activating TRPV1 channel and through activation of the nuclear factor-κB (NF-κB) pathway. Male Wistar rats were randomly divided into the sodium hydrosulfide (NaHS, 100 μmol/kg b.w.) group, pyrrolidine dithiocarbamate (PDTC, 100 μmol/kg b.w.) group, PDTC (100 μmol/kg b.w.) + NaHS (100 μmol /kg b.w.) group, capsazepine (0.1 mM) + NaHS (100 μmol /kg b.w.) group and L703606 (0...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279304/recent-advances-in-the-role-of-amp-activated-protein-kinase-in-metabolic-reprogramming-of-metastatic-cancer-cells-targeting-cellular-bioenergetics-and-biosynthetic-pathways-for-anti-tumor-treatment
#17
REVIEW
M Tyszka-Czochara, P Konieczny, M Majka
Growing data indicate that tumor progression and metastasis is dependent on the reprograming of cellular metabolism. Rapidly growing cancer cells undergo metabolic stress in a harsh microenvironment. AMP-activated protein kinase (AMPK) is an energy sensing factor that regulates bioenergetics and biosynthetic pathways within the cell, but its role under metastasis is in dispute. The best studied phenotype of cancer cells is aerobic glycolysis (the Warburg effect), an increased catabolism of glucose to lactate...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30279303/the-effect-of-tropaeolum-majus-l-on-bacterial-infections-and-in-vitro-efficacy-on-apoptosis-and-dna-lesions-in-hyperosmotic-stress
#18
T Jurca, I Baldea, G A Filip, D Olteanu, S Clichici, A Pallag, L Vicas, E Marian, O Micle, M Muresan
Tropaeolum majus L. (T. majus) or nasturtium is a medicinal plant widespread in the areas with temperate climate, commonly used in culinary and in traditional medicine due to therapeutic properties. In the last few years, various effects of the flowers and leaves of this plant have been studied, but their benefits are not fully known. The aim of the study was to identify the phenolic compounds from T. majus edible flowers in relation with its antioxidant capacity and the antimicrobial activity against different bacteria and Candida albicans...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30149371/sperm-mitochondrial-dysfunction-and-oxidative-stress-as-possible-reasons-for-isolated-asthenozoospermia
#19
K Nowicka-Bauer, A Lepczynski, M Ozgo, M Kamieniczna, M Fraczek, L Stanski, M Olszewska, A Malcher, W Skrzypczak, M K Kurpisz
Reduced sperm motility, defined as asthenozoospermia, is a frequent cause of male infertility, and is mainly connected with the dysfunction of sperm mitochondria. The aim of this study was to identify the proteins, and thereby the metabolic pathways, responsible for asthenozoospermia, using 2-DE and MALDI-TOF MS, and correlate the results obtained with those of two mitochondrial tests: JC-1 and MitoSox Red. The JC-1 test was performed to test sperm mitochondrial activity, and the MitoSox Red test was performed to check whether the observed sperm poor motility is associated with mitochondrial reactive oxygen species (ROS) production...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30149370/regulation-of-steroidogenic-function-of-mouse-leydig-cells-g-coupled-membrane-estrogen-receptor-and-peroxisome-proliferator-activated-receptor-partnership
#20
E Gorowska-Wojtowicz, P Dutka, M Kudrycka, P Pawlicki, A Milon, B J Plachno, W Tworzydlo, L Pardyak, A Kaminska, A Hejmej, B Bilinska, M Kotula-Balak
We tested whether G-coupled membrane estrogen receptor (GPER) and peroxisome proliferator activated receptor (PPAR) partnership exists and whether this interaction regulates mouse Leydig cell function. Mature and aged mice were treated with the antagonist of GPER (G-15; 50 μg/kg b.w). Leydig cells (MA-10) were treated with G-15 (10 nM) alone or in combination with peroxisome proliferator-activated receptor α or γ antagonists, respectively (PPARα, 10 μM; PPARγ, 10 μM). GPER blockage affected testis steroidogenic status via changes in lutropin and cholesterol levels as well as protein expression alterations of the lutropin receptor, acute steroidogenesis activating protein, translocator protein, and protein kinase A in mouse Leydig cells both in vivo and in vitro...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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