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Inflammopharmacology

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https://www.readbyqxmd.com/read/29138954/identification-of-compounds-from-palicourea-rigida-leaves-with-topical-anti-inflammatory-potential-using-experimental-models
#1
Rafael P Pinheiro, Muiara A Moraes, Bruna C S Santos, Rodrigo L Fabri, Glauciemar Del-Vechio-Vieira, Célia H Yamamoto, Ana Lúcia S M Araújo, Aílson L A Araújo, Orlando V Sousa
Palicourea rigida Kunth is traditionally used for the treatment of skin diseases, kidney pains and ovarian inflammation. Based on these traditional uses, this study evaluated the topical anti-inflammatory activity of the ethanol extract from P. rigida leaves (EEPR) and identified bioactive compounds. Ear edema was induced in Swiss mice by the topical application of Croton oil, arachidonic acid, phenol and capsaicin. Histopathological analysis and myeloperoxidase and N-acetyl-β-D-glucosaminidase activities were determined...
November 14, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29116460/potential-usefulness-of-methyl-gallate-in-the-treatment-of-experimental-colitis
#2
María Laura Anzoise, Angeles Rodríguez Basso, Julieta Sofía Del Mauro, Andrea Carranza, Graciela López Ordieres, Susana Gorzalczany
Methyl gallate is a gallotannin widely distributed in nature. Previous studies have demonstrated its antioxidant, anti-inflammatory, antimicrobial and anti-tumor activities. In the present study, the activity of methyl gallate on experimental models of inflammatory bowel disease has been investigated. Experimental colitis was induced in Sprague-Dawley rats through the intracolonic instillation of an acetic acid solution (2 mL, 4% v/v). Methyl gallate (100 and 300 mg/kg, p.o.) and the reference drug mesalazine (100 mg/kg, p...
November 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29110118/microrna-in-gastrointestinal-cell-signalling
#3
REVIEW
Priyanka Mishra, Divya Singh, Lilly Ganju, Bhuvnesh Kumar
Our gut forms an important organ and its formation, functioning and homeostasis are maintained by several factors including cell signalling pathways and commensal microflora. These factors affect pathological, physiological and immunological parameters to maintain gut health and prevent its inflammation. Among these, different intracellular signalling pathways play an important role in regulating gut homeostasis. These pathways are in turn regulated by various microRNAs that play a key role in maintaining the balance between tolerance and inflammation...
November 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29098546/silymarin-mitigates-lung-impairments-in-a-rat-model-of-acute-respiratory-distress-syndrome
#4
Zhongming Zhu, Gengyun Sun
Acute respiratory distress syndrome (ARDS) is a deadly disease and lacks effective treatments. Inflammation and oxidative stress play key roles in ARDS development. We aimed to evaluate the efficacy of pretreatment of silymarin, which has capacities of anti-inflammatory and anti-oxidative stress, in ARDS. We used lipopolysaccharide (LPS) to generate an ARDS rat model, which was pretreated with silymarin. Lung wet/dry ratio and broncho-alveolar lavage fluid (BALF) analyses were performed. Histological changes of the lungs were evaluated using hematoxylin and eosin staining...
November 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29094308/ameliorative-potential-of-rutin-in-combination-with-nimesulide-in-stz-model-of-diabetic-neuropathy-targeting-nrf2-ho-1-nf-kb-and-cox-signalling-pathway
#5
Ruchika Mittal, Anil Kumar, Dhirendra Pratap Singh, Mahendra Bishnoi, Tapas Chandra Nag
Emerging role of Nrf-2/HO-1 in pathogenesis of diabetic neuropathy has been suggested. Diabetic neuropathy is one of the most common complications of diabetes and more than 50% patients of diabetes develop diabetic neuropathy. Rutin has been well documented to show protective effect in various complications, e.g., diabetic neuropathy. However, its mechanistic insight is still not completely understood. The present study has been designed to explore the protective effect of rutin and its interaction with COX-2 inhibitor, nimesulide in diabetic neuropathy...
November 1, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29094307/plant-based-chimeric-hpv-virus-like-particles-bearing-amyloid-%C3%AE-epitopes-elicit-antibodies-able-to-recognize-amyloid-plaques-in-app-tg-mouse-and-alzheimer-s-disease-brains
#6
R Gonzalez-Castro, G Acero Galindo, Y García Salcedo, L Uribe Campero, V Vazquez Perez, M Carrillo-Tripp, G Gevorkian, M A Gomez Lim
The main amyloid-beta (Aβ) variants detected in the human brain are full-length Aβ1-40 and Aβ1-42 peptides; however, a significant proportion of AD brain Aβ consists also of N-terminal truncated/modified species. The majority of the previous immunotherapeutic strategies targeted the N-terminal immunodominant epitope of the full-length Aβ; however, most of the pathological N-truncated forms of Aβ lack this critical B cell epitope. Recently, virus-like particles (VLPs), self-assembled structures with highly ordered repetitive patterns on their surface and capable of inducing robust immune responses, were applied as a promising platform for various antigen expressions...
November 1, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29071457/evaluation-of-cebranopadol-a-dually-acting-nociceptin-orphanin-fq-and-opioid-receptor-agonist-in-mouse-models-of-acute-tonic-and-chemotherapy-induced-neuropathic-pain
#7
Kinga Sałat, Anna Furgała, Robert Sałat
BACKGROUND: Cebranopadol (a.k.a. GRT-6005) is a dually acting nociceptin/orphanin FQ and opioid receptor agonist that has been recently developed in Phase 2 clinical trials for painful diabetic neuropathy or cancer pain. It also showed analgesic properties in various rat models of pain and had a better safety profile as compared to equi-analgesic doses of morphine. Since antinociceptive properties of cebranopadol have been studied mainly in rat models, in the present study, we assessed analgesic activity of subcutaneous cebranopadol (10 mg/kg) in various mouse pain models...
October 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29067571/foeniculum-vulgare-essential-oil-ameliorates-acetic-acid-induced-colitis-in-rats-through-the-inhibition-of-nf-kb-pathway
#8
Seyed Mahdi Rezayat, Ahmad-Reza Dehpour, Saeed Mohammadi Motamed, Maryam Yazdanparast, Mohsen Chamanara, Mousa Sahebgharani, Amir Rashidian
AIM: The aim of the present study is to investigate the protective effects of Foeniculum vulgare essential oil on intestinal inflammation through the inhibition of NF-kB pathway in acetic acid-induced rat colitis. METHODS: Acute colitis was induced by intra-rectal administration of 2 mL of diluted acetic acid (4%) solution. Two hours after the induction of colitis, 0.2% tween 80 in normal saline, dexamethasone (2 mg/kg) and F. vulgare essential oil (100, 200, 400 mg/kg) were administered to the animals by oral gavage and continued for 5 consecutive days...
October 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29063489/mesenchymal-stromal-cells-modulate-gut-inflammation-in-experimental-colitis
#9
Cristhiane Favero de Aguiar, Angela Castoldi, Vinícius Andrade-Oliveira, Aline Ignacio, Flávia Franco da Cunha, Raphael José Ferreira Felizardo, Ênio José Bassi, Niels Olsen Saraiva Câmara, Danilo Candido de Almeida
Inflammatory bowel diseases (IBDs) affect millions of people worldwide and their frequencies in developed countries have increased since the twentieth century. In this context, there is an intensive search for therapies that modulate inflammation and provide tissue regeneration in IBDs. Recently, the immunomodulatory activity of adipose tissue-derived mesenchymal stromal cells (ADMSCs) has been demonstrated to play an important role on several immune cells in different conditions of inflammatory and autoimmune diseases...
October 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29063488/attenuation-of-nociceptive-pain-and-inflammatory-disorders-by-total-steroid-and-terpenoid-fraction-of-euphorbia-tirucalli-linn-root-in-experimental-in-vitro-and-in-vivo-model
#10
Partha Palit, Dhrubojyoti Mukherjee, Poulami Mahanta, Md Shadab, Nahid Ali, Shubhadeep Roychoudhury, Md Asad, Subhash C Mandal
The plant Euphorbia tirucalli Linn has been successfully used as a tribal folk medicine in India and Africa for the management of acute inflammatory, arthritic, nociceptive pain and asthmatic symptoms. The present study was conducted to assess the anti-inflammatory, analgesic, anti-asthmatic and anti-arthritic role of the total steroid and terpenoid rich fractions of the hydro-alcoholic extract of E. tirucalli root (STF-HAETR). STF-HAETR fraction demonstrated 71.25 ± 2.5 and 74.25 ± 5.1% protection against acetic acid-induced pain and central neuropathic pain at 75 and 100 mg/kg doses, respectively...
October 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29063487/targeting-of-circulating-th17-cells-by-%C3%AE-d-mannuronic-acid-m2000-as-a-novel-medication-in-patients-with-rheumatoid-arthritis
#11
Hossein Ahmadi, Mahdi Mahmoudi, Farhad Gharibdoost, Mahdi Vojdanian, Ahmad Reza Jamshidi, Mohammad Javad Fattahi, Zahra Aghazadeh, Anis Barati, Abbas Mirshafiey
OBJECTIVE: This study aimed at investigating the inhibitory effect of β-D-mannuronic acid (M2000) on the Th17 circulating levels and IL-17 a related cytokine in rheumatoid arthritis (RA) patients. METHODS: The study included 27 patients with RA who had failed response to treatment. All patients were treated orally by M2000 at a dose of 500 mg twice daily for 12 weeks (Clinical trial identifier: IRCT2014011213739N2). The patients based on anti-tumor necrosis factor alpha (TNFα) blocker treatment were classified into two groups (conventional group and etanercept group)...
October 23, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29052795/effects-of-glutamine-taurine-and-their-association-on-inflammatory-pathway-markers-in-macrophages
#12
Talita Sartori, Guilherme Galvão Dos Santos, Amanda Nogueira-Pedro, Edson Makiyama, Marcelo Macedo Rogero, Primavera Borelli, Ricardo Ambrósio Fock
The immune system is essential for the control and elimination of infections, and macrophages are cells that act as important players in orchestrating the various parts of the inflammatory/immune response. Amino acids play important role in mediating functionality of the inflammatory response, especially mediating macrophages functions and cytokines production. We investigated the influence of glutamine, taurine and their association on the modulation of inflammatory pathway markers in macrophages. The RAW 264...
October 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29027056/curcumin-affords-neuroprotection-and-inhibits-%C3%AE-synuclein-aggregation-in-lipopolysaccharide-induced-parkinson-s-disease-model
#13
Neha Sharma, Bimla Nehru
Parkinson's disease (PD) pathology is characterized by the abnormal accumulation and aggregation of the pre-synaptic protein α-synuclein in the dopaminergic neurons as Lewy bodies (LBs). Curcumin, which plays a neuroprotective role in various animal models of PD, was found to directly modulate the aggregation of α-synuclein in in vitro as well as in in vivo studies. While curcumin has been shown to exhibit strong anti-oxidant and anti-inflammatory properties, there are a number of other possible mechanisms by which curcumin may alter α-synuclein aggregation which still remains obscure...
October 12, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28988328/acacetin-attenuates-mice-endotoxin-induced-acute-lung-injury-via-augmentation-of-heme-oxygenase-1-activity
#14
Dongdong Wu, Yanan Wang, Heng Zhang, Minghua Du, Tanshi Li
Acacetin, a natural product, has a wide spectrum of biological activities such as antioxidant properties. In the present study, we examined whether Acacetin has any beneficial role on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and, if so, whether its effect is mediated via heme oxygenase-1 (HO-1), an antioxidant enzyme playing an important role in ALI. Male BALB/c mice were stimulated with LPS intratracheal instillation to induce ALI. Acacetin was administrated 2 h after LPS challenge. Samples were harvested 10 h after LPS administration...
October 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28988279/caffeic-acid-combined-with-autoclaved-leishmania-major-boosted-the-protection-of-infected-balb-c-mice-by-enhancing-igg2-production-ifn-%C3%AE-tgf-%C3%AE-and-ino-synthase-arginase1-ratios-and-the-death-of-infected-phagocytes
#15
Radia Belkhelfa-Slimani, Bahia Djerdjouri
BACKGROUND: Immunization with killed Leishmania promastigotes without adjuvant was considered as safe, but gave variable rates of protection. Taking advantage of the immuno-modulatory effect of caffeic acid (CA), a natural polyphenolic antioxidant, we investigated its potentiating effect in autoclaved Leishmania major (ALM)-induced protection of Leishmania major-infected BALB/c. METHODS: First, BALB/c mice were sensitized for 6 weeks either with CA, or ALM alone or combined with caffeic acid (ALM-CA) or Freund's adjuvant (ALM-FA), and subsequently infected with L...
October 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28965161/pharmacological-inhibition-of-the-nlrp3-inflammasome-as-a-potential-target-for-multiple-sclerosis-induced-central-neuropathic-pain
#16
Nemat Khan, Andy Kuo, David A Brockman, Matthew A Cooper, Maree T Smith
The NOD-like receptor (NLR) family pyrin domain-containing protein 3 (NLRP3) inflammasome is implicated in the pathogenesis of multiple diseases including neuroinflammation associated with multiple sclerosis (MS). However, the extent to which NLRP3 has a pathobiological role in MS-associated central neuropathic pain (CNP) is unknown. Hence, the present study was designed to address this issue using an optimised relapsing-remitting experimental encephalomyelitis (RR-EAE)-mouse model of MS-associated neuropathic pain...
September 30, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28940033/in-vitro-effect-of-flaxseed-oil-and-%C3%AE-linolenic-acid-against-the-toxicity-of-lipopolysaccharide-lps-to-human-umbilical-vein-endothelial-cells
#17
Yuexin Shen, Gui Chen, Aiping Xiao, Yixi Xie, Liangliang Liu, Yi Cao
Consumption of α-linolenic acid (ALA)-rich flaxseed oil is a possible way to supplement ω-3 polyunsaturated fatty acids, but the beneficial effects to cardiovascular systems are still controversial. In this study, human umbilical vein endothelial cells (HUVECs) treated with 100 ng/mL lipopolysaccharide (LPS) were used as the in vitro model and the potential beneficial effects of well-characterized flaxseed oil and ALA were studied. Exposure of HUVECs to LPS for 24 h significantly promoted inflammatory response as release of interleukin 6 (IL-6), soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) as well as adhesion of THP-1 monocytes, but did not induce cytotoxicity or oxidative stress...
September 22, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28918573/anti-inflammatory-effects-of-ginkgo-biloba-extract-against-trimethyltin-induced-hippocampal-neuronal-injury
#18
Sukhwinder Kaur, Neha Sharma, Bimla Nehru
BACKGROUND: Despite the immense neuromodulatory potentials of Ginkgo biloba extract as a memory enhancer, its underlying mechanism seems inadequate particularly with regard to its anti-inflammatory properties. AIM: The objective of the present study is to investigate the protective potentials of Ginkgo biloba extract (GBE) against hippocampal neuronal injury induced by trimethyltin (TMT), a potent neurotoxicant. METHODS: Male SD rats were administered trimethyltin (8...
September 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28889355/tingenone-a-pentacyclic-triterpene-induces-peripheral-antinociception-due-to-cannabinoid-receptors-activation-in-mice
#19
C C Veloso, R C M Ferreira, V G Rodrigues, L P Duarte, A Klein, I D Duarte, T R L Romero, A C Perez
Several works have shown that triterpenes induce peripheral antinociception by activation of cannabinoid receptors and endocannabinoids; besides, several research groups have reported activation of cannabinoid receptors in peripheral antinociception. The aim of this study was to assess the involvement of the cannabinoid system in the antinociceptive effect induced by tingenone against hyperalgesia evoked by prostaglandin E2 (PGE2) at peripheral level. The paw pressure test was used and the hyperalgesia was induced by intraplantar injection of PGE2 (2 μg/paw)...
September 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28879572/diligustilide-releases-h2s-and-stabilizes-s-nitrosothiols-in-ethanol-induced-lesions-on-rat-gastric-mucosa
#20
Josué Arturo Velázquez-Moyado, José Luis Balderas-López, Elizabeth Arlen Pineda-Peña, Brenda Lorena Sánchez-Ortiz, José Carlos Tavares-Carvalho, Andrés Navarrete
(Z,Z')-Diligustilide (DLG) or levistolide A is a dimeric phthalide isolated from Ligusticum porteri (Osha), the roots of which are used in the traditional treatment of many diseases including gastric aches. However, its action has not been completely elucidated. We analyzed the contributions of hydrogen sulfide and S-nitrosothiols to the action of DLG. Animals were pretreated with freshly formed in vitro nitrosothiol using Na2S and sodium nitroprusside to elucidate participation in the action of DLG. We also evaluated the production of H2S in vivo and in real time on the stomach via a specific electrode introduced into the stomachs of anaesthetized animals pretreated with DLG...
September 6, 2017: Inflammopharmacology
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