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Inflammopharmacology

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https://www.readbyqxmd.com/read/29327283/persea-americana-mill-crude-extract-exhibits-antinociceptive-effect-on-uvb-radiation-induced-skin-injury-in-mice
#1
Viviane C K N Deuschle, Indiara Brusco, Mariana Piana, Henrique Faccin, Leandro Machado de Carvalho, Sara Marchesan Oliveira, Carine Viana
Persea americana, popularly known as avocado, has been empirically used as analgesic and anti-inflammatory including in the skin disorder treatment. Species of the genus Persea also show a photoprotective effect against UVB radiation. We investigated the antinociceptive and anti-inflammatory effects from a topical formulation containing the P. americana leaf extract in a UVB irradiation-induced burn model in mice and performed a gel-formulation stability study. The antinociceptive and anti-inflammatory effect was evaluated through mechanical allodynia, paw oedema, and inflammatory cell infiltration...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29327282/ziziphus-spina-christi-leaf-extract-pretreatment-inhibits-liver-and-spleen-injury-in-a-mouse-model-of-sepsis-via-anti-oxidant-and-anti-inflammatory-effects
#2
Mohamed A Dkhil, Saleh Al-Quraishy, Ahmed E Abdel Moneim
Sepsis is a systemic response to infection that can result in acute hepatic and splenic damage. Ziziphus spina-christi (L.) is a wild tree used as a medicinal plant by ancient Egyptians. However, little is known about the mechanism underlying its effects on sepsis. The current study investigated the protective effects of a Z. spina-christi leaf extract (ZSCLE) on liver and spleen damage in a male C57BL/6 mouse model of sepsis, induced by cecal ligation and puncture (CLP). Prior to CLP, ZSCLE was administered daily for five consecutive days via oral gavage at doses of 100, 200, or 300 mg/kg...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29327281/effect-of-early-natal-supplementation-of-paracetamol-on-attenuation-of-exotoxin-endotoxin-induced-pyrexia-and-precipitation-of-autistic-like-features-in-albino-rats
#3
Abdulaziz S Saeedan, Indu Singh, Mohd Nazam Ansari, Manjari Singh, Jitendra K Rawat, Uma Devi, Swetlana Gautam, Rajnish K Yadav, Gaurav Kaithwas
The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test...
January 11, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29313174/polar-extract-of-curcuma-longa-protects-cartilage-homeostasis-possible-mechanism-of-action
#4
Chandrasekaran Chinampudur Velusami, Edwin Jothie Richard, Bharathi Bethapudi
BACKGROUND: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action. METHODS: Dysregulation of cartilage homeostasis was induced by IL-1β and H2O2. Modulating effects of NR-INF-02 on degradation markers viz., chondrocyte apoptosis, senescence, cytokine, eicosanoids, and cartilage synthesis markers viz...
January 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29302905/the-efficacy-of-probiotic-supplementation-in-rheumatoid-arthritis-a-meta-analysis-of-randomized-controlled-trials
#5
Seyed Mohammad Aqaeinezhad Rudbane, Samane Rahmdel, Seyedeh Maryam Abdollahzadeh, Morteza Zare, Azam Bazrafshan, Seyed Mohammad Mazloomi
Probiotics are considered as -immunomodulatory agents; their efficacy as an adjunct therapy option for rheumatoid arthritis (RA), however, remains controversial. The main aim of the present meta-analysis, therefore, was to compare available data from the published randomized, controlled trials (RCTs) recruiting adults with RA which compared probiotics with placebo. The English literature search was performed using Ovid version of Medline, EmBase, Web of Science, and the Central Cochrane library through October 2016 and supplemented by hand searching reference lists...
January 4, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29289998/molecular-signature-of-nitric-oxide-on-major-cancer-hallmarks-of-colorectal-carcinoma
#6
REVIEW
Paramita Mandal
Colorectal cancer (CRC) is the one of the most important diseases throughout the world. Several aetiological risk factors, viz. sedentary life style, smoking, alcohol intake, less physical activity, red meat, and microbiota, are associated with the development of CRC. Molecular pathophysiology of CRC implies inflammation, metastasis, apotosis and angiogenesis. Inflammation involves interaction between various immune cells, inflammatory cells, chemokines, cytokines, and pro-inflammatory mediators, such as cyclooxygenase (COX) and lipoxygenase (LOX) pathways, which may lead to signalling towards, tumour cell proliferation, growth, and invasion whereas nitric oxide (NO) has been associated with metastasis, apoptosis, and angiogenesis...
December 30, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29282585/as-a-painkiller-a-review-of-pre-and-postnatal-non-steroidal-anti-inflammatory-drug-exposure-effects-on-the-nervous-systems
#7
REVIEW
Kıymet Kubra Yurt, Suleyman Kaplan
Diclofenac sodium (DS) is commonly used for the treatment of acute and chronic pain, even for extended periods of time. Over the years, DS has been associated with toxicity in nervous tissue, in addition to its anti-inflammatory properties. Basic neurobiological research has enhanced our understanding of the biological and pathological outcomes of toxicity. Several studies have suggested DS-induced cytotoxicity in the nervous system. Prenatal toxicities of DS are thought to be capable of leading to postnatal defects...
December 27, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29249049/tramadol-ameliorates-behavioural-biochemical-mitochondrial-and-histological-alterations-in-icv-stz-induced-sporadic-dementia-of-alzheimer-s-type-in-rats
#8
Dinesh K Dhull, Anil Kumar
Alzheimer disease represents a major public health issue with limited therapeutic interventions. We explored the possibility of therapeutic approach by repurposing of tramadol in a sporadic animal model of Alzheimer's type. Streptozocin (STZ 3 mg/kg; bilaterally) was injected to male SD rats through intracerebroventricular (ICV) route. Drug treatment was started just after streptozocin administration and continued for 3 weeks. The rats were killed on the 21st day following the last behavioral test, and cytoplasmic fractions of the hippocampus and pre-frontal cortex were prepared for the quantification of acetylcholinesterase, oxidative stress parameter, mitochondrial enzymes activity and histological examination...
December 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29247373/-epigallocatechin-3-gallate-the-major-green-tea-catechin-regulates-the-desensitization-of-%C3%AE-1-adrenoceptor-via-grk2-in-experimental-heart-failure
#9
Qi Zhang, Liqun Hu, Li Chen, Hongqi Li, Jun Wu, Wenting Liu, Mengyuan Zhang, Guang Yan
OBJECTIVE: We investigated the effect of (-)-epigallocatechin-3-gallate (EGCG) on cardiac function and its mechanism, which focused on the desensitization of β1-AR and GRK2 in heart failure (HF) rats. METHODS: HF was induced by abdominal aortic coarctation. Four weeks after HF induction, the rats were given EGCG (25, 50, 100 mg/kg/day). Cardiac function was assessed by measuring haemodynamic parameters. Histological changes were analyzed by HE and Masson's trichrome staining...
December 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29238904/anti-inflammatory-activity-of-anti-hyperlipidemic-drug-fenofibrate-and-its-phase-i-metabolite-fenofibric-acid-in-silico-in-vitro-and-in-vivo-studies
#10
G Shyam Prasad, P Govardhan, G Deepika, V Vakdevi, R B Sashidhar
Fenofibrate, an anti-hyperlipidemic drug and its phase-I biotransformed metabolite fenofibric acid, was studied for COX-1 (PDB ID: 3N8Y) and COX-2 (PDB ID: 1PXX) inhibition potentials in silico and in vitro for their effects on human recombinant COX-2 enzyme isolated from a Baculovirus expression system in sf21 cells (EC 1.14.99.1) using a conventional spectrophotometric assay. Furthermore, the compounds were also screened for their anti-inflammatory potentials in vivo using carrageenan-induced paw oedema method in Wistar rats...
December 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29224178/evaluation-of-the-anti-inflammatory-and-urotoxicity-ameliorative-effects-of-%C3%AE-humulene-containing-active-fraction-of-emilia-sonchifolia-l-dc
#11
Gilcy George Kallivalappil, Girija Kuttan
In folklore medicine, the plant Emilia sonchifolia, belonging to the family Asteraceae, is used for treating tumour and inflammation. In our previous studies, we have done a thorough phytochemical investigation of E. sonchifolia with a report on its potent antimetastatic activity. Further, we isolated and characterised its active fraction (AFES) containing the major compound γ-humulene with an evaluation of the antiangiogenic effect of AFES (5 mg/kg b.wt.). In the first part of the present study, AFES in different concentrations was used for the assessment of its possible anti-inflammatory effect employing three in vivo inflammatory models...
December 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29222687/chrysophyllum-cainito-apple-star-a-fruit-with-gastroprotective-activity-in-experimental-ulcer-models
#12
Roseane Leandra da Rosa, Camila Leandra de Almeida, Lincon Bordigon Somensi, Thaise Boeing, Luisa Nathália Bolda Mariano, Clarissa de Medeiros Amorim Krueger, Priscila de Souza, Valdir Cechinel Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
The gastroprotective potential of the methanolic extracts from peels (MEPe), seeds (MESe) and pulp (MEPu) of Chrysophyllum cainito L. (Sapotaceae) fruits was evaluated in mice using ethanol/HCl- and indomethacin-induced ulcer, as well as the antiulcer effect of the juice and flour from this fruit. The lowest oral gastroprotective dose of MEPe, MESe and MEPu against ethanol/HCl was 3, 3 and 10 mg/kg, respectively. Moreover, all extracts increased mucin secretion at 176, 198 and 193%. Intraperitoneal administration of MEPe (0...
December 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29204780/silver-oxide-nanoparticles-alleviate-indomethacin-induced-gastric-injury-a-novel-antiulcer-agent
#13
Neveen A Salem, Mohammed A Wahba, Wael H Eisa, Marwa El-Shamarka, Wagdy Khalil
Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide...
December 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29197932/evaluation-of-the-anti-inflammatory-effect-of-an-anti-platelet-agent-crinumin-on-carrageenan-induced-paw-oedema-and-granuloma-tissue-formation-in-rats
#14
Uddipak Rai, Amrita Rawal, Sanjay Singh
The present study was designed to explore the anti-inflammatory activity of an anti-platelet agent crinumin, by various in vitro and in vivo inflammation models. Firstly, crinumin protein was purified through cation exchange chromatography; then, in vitro activity was estimated by albumin denaturation assay and HRBC membrane stabilization assay. Carrageenan-induced paw oedema and cotton pellet-induced granuloma models were used for in vivo anti-inflammatory activity assessment in rats. In both models, rats were pre-treated for 7 days with crinumin (25-50 µg/ml) and diclofenac sodium (50 µg/ml)...
December 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29188473/effect-of-simvastatin-on-sensorial-motor-and-morphological-parameters-in-sciatic-nerve-crush-induced-neuropathic-pain-in-rats
#15
Claudia Rita Corso, Daniel Fernandes Martins, Stephanie Carvalho Borges, Olair Carlos Beltrame, José Ederaldo Queiroz Telles, Nilza Cristina Buttow, Maria Fernanda de Paula Werner
The present study compares the effects of a low and high doses of simvastatin in a model of peripheral neuropathy by evaluating sensorial, motor, and morphological parameters. First, male Wistar rats were orally treated with vehicle (saline, 1 mL/kg), simvastatin (2 and 80 mg/kg) or morphine (2 mg/kg, s.c.), 1 h before 2.5% formalin injection. Neuropathic pain was induced by crushing the sciatic nerve, and mechanical and cold allodynia, nerve function, histology, MPO and NAG concentrations, as well as mevalonate induced-nociception were evaluated...
November 29, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29185178/vasorelaxant-activities-and-the-underlying-pharmacological-mechanisms-of-gynura-procumbens-merr-leaf-extracts-on-rat-thoracic-aorta
#16
Zafar Iqbal, Idris Bello, Mohd Zaini Asmawi, Majed Ahmed Al-Mansoub, Ashfaq Ahmad, Qaiser Jabeen, Yam Mun Fei
Previous studies have investigated the cardiovascular activity of Gynura procumbens Merr. single-solvent extracts. The objective of this study was to evaluate the in vitro vasorelaxant properties and the underlying pharmacological mechanisms of serial extracts and fractions of Gynura procumbens (GP). The leaves of GP were serially extracted with petroleum ether, chloroform, methanol and water using the maceration method. Suspended aortic ring preparations were pre-contracted with phenylephrine (PE 1 µM), followed by cumulative addition of GP extracts (0...
November 28, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29159717/analgesic-anti-inflammatory-and-anticancer-activities-of-combretin-a-and-combretin-b-isolated-from-combretum-fragrans-f-hoffm-combretaceae-leaves
#17
Marius Mbiantcha, Jabeen Almas, Amadou Dawe, Aisha Faheem, Zafar Sidra
Previous pharmacological and phytochemical studies showed that, Combretum fragrans F. HOFFM (Combretaceae) is a Cameroonian medicinal plant possessing numerous therapeutic virtues and rich in various active secondary metabolites. In this study, we investigate in vivo anti-nociceptive and anti-inflammatory activity and, in vitro anticancer, anti-TNFα, ROS and NO-inhibitory activities of Combretum A and Combretin B, two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans. The effect on ROS, TNF-α and NO production, anticancer activity and cytotoxicity assay were done using chemiluminescence technique, ELISA kit, colorimetric method, MCF-7 cells and MTT assay, respectively...
November 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29159716/rotula-aquatica-lour-attenuates-secretion-of-proinflammatory-mediators-and-cytokines-in-lipopolysaccharide-induced-inflammatory-responses-in-murine-raw-264-7-macrophages
#18
A Vysakh, Prasad Gopika, Kuriakose Jayesh, Raj Karishma, M S Latha
Rotula aquatica belongs to the family Boraginaceae, and is reported to contain baunerol, steroids and alkaloids. In Ayurveda, R. aquatica has been used for the treatment of various diseases such as diabetes, treatment of piles, venereal disease, and cancer. The current study aims to investigate the anti-inflammatory effect of methanolic extract of R. aquatica (MERA) in RAW 264.7 cells. The cytotoxicity of MERA was analyzed by MTT assay. The total cyclooxygenase (COX) activity, 5-lipoxygenase (5-LOX) activity, myeloperoxidase activity, inducible nitric oxide synthase activity, nitrate level and reactive oxygen species production were studied in LPS-stimulated RAW 264...
November 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29159715/does-the-administration-of-melatonin-during-post-traumatic-brain-injury-affect-cytokine-levels
#19
Fatemeh Dehghan, Nader Shahrokhi, Mohammad Khaksari, Zahra Soltani, Gholamreza Asadikorom, Ali Najafi, Nava Shahrokhi
Increased levels of inflammatory cytokines after traumatic brain injury (TBI) can lead to brain edema and neuronal death. In this study, the effect of melatonin on pro-inflammatory (IL-1ß, IL-6, and TNF-α) and anti-inflammatory (IL-10) cytokines following TBI was investigated considering anti-inflammatory effect of melatonin. Male Wistar rats were divided into five groups: Sham, TBI, TBI + VEH (vehicle), TBI + 5 mg dose of melatonin (MEL5), TBI + 20 mg dose of melatonin (MEL20). Diffuse TBI was induced by Marmarou method...
November 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29159714/regulatory-effects-of-dexamethasone-on-nk-and-t-cell-immunity
#20
Liying Chen, Mikael Jondal, Konstantin Yakimchuk
Glucocorticoids (GCs) act via the intracellular glucocorticoid receptor (GR), which can regulate the expression of target genes. With regard to the immune system, GCs may affect both innate and adaptive immunity. Our study analyzed the immunoregulatory effects of dexamethasone (Dex) treatment on splenic T, Treg, NK and NKT cells by treating C57Bl6 mice with various doses of Dex. We observed that treatment with Dex decreased the number of NK cells in the spleen and suppressed their activity. In particular, the expression of both Ly49G and NKG2D receptors was decreased by Dex...
November 20, 2017: Inflammopharmacology
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