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Inflammopharmacology

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https://www.readbyqxmd.com/read/27878500/anti-inflammatory-and-antioxidant-effect-of-kerabala-a-value-added-ayurvedic-formulation-from-virgin-coconut-oil-inhibits-pathogenesis-in-adjuvant-induced-arthritis
#1
M Ratheesh, S Sandya, C Pramod, S Asha, Jose P Svenia, S Premlal, B GrishKumar
Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-induced acute and adjuvant-induced chronic experimental models. 5 mg/kg bwt was found to be potent dose from carrageenan model and evaluated its effect in adjuvant-induced chronic arthritic model...
November 22, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27873165/analysing-the-effect-of-i1-imidazoline-receptor-ligands-on-dss-induced-acute-colitis-in-mice
#2
Ágnes Fehér, Viktória E Tóth, Mahmoud Al-Khrasani, Mihály Balogh, Bernadette Lázár, Zsuzsanna Helyes, Klára Gyires, Zoltán S Zádori
Imidazoline receptors (IRs) have been recognized as promising targets in the treatment of numerous diseases; and moxonidine and rilmenidine, agonists of I1-IRs, are widely used as antihypertensive agents. Some evidence suggests that IR ligands may induce anti-inflammatory effects acting on I1-IRs or other molecular targets, which could be beneficial in patients with inflammatory bowel disease (IBD). On the other hand, several IR ligands may stimulate also alpha2-adrenoceptors, which were earlier shown to inhibit, but in more recent studies to rather aggravate colitis...
November 21, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27853891/impact-of-extended-ginsenoside-rb1-on-early-chronic-kidney-disease-a-randomized-placebo-controlled-study
#3
Xuefang Xu, Qiandi Lu, Jingyue Wu, Yixiang Li, Jinzhu Sun
Ginsenoside Rb1 (GS-Rb1) is a well-known antioxidant derived from traditionally used herbal medicine ginseng. It has been suggested that reactive oxygen species (ROS) is involved in chronic kidney disease (CKD) in which GS-Rb1 may play a protective role. The aim of this study was to evaluate prospectively the effects of GS-Rb1 in patients with early chronic kidney disease. 197 patients who have been diagnosed with early CKD (stage 2 or 3) were recruited and randomly assigned to receive GS-Rb1 (500 mg daily oral administration, n = 103) or placebo (n = 94) for consecutive 6 months...
November 17, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27853890/neuroprotective-potential-of-curcumin-in-combination-with-piperine-against-6-hydroxy-dopamine-induced-motor-deficit-and-neurochemical-alterations-in-rats
#4
Shamsher Singh, Puneet Kumar
AIM AND OBJECTIVE: 6-hydroxy dopamine (6-OHDA) is a neurotoxin which on intranigral administration produces severe nigrostriatal damage with motor and cognitive deficit in animals. Curcumin (CMN) in combination with bioenhancer piperine (PP) in 6-hydroxydopamine-induced Parkinsonian rats was used to investigate the antioxidant, neuromodulatory and neuroprotective mechanisms. MATERIALS AND METHODS: Hemi-Parkinson's rat model was developed with intranigral infusion of 6-OHDA (8 μg/2 μl, once, unilaterally), treatment with CMN (25 and 50 mg/kg) and combination of PP (2...
November 16, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27822636/origins-of-inflammopharmacology-twenty-five-years-on
#5
EDITORIAL
K D Rainsford
No abstract text is available yet for this article.
November 8, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27796724/effects-of-methanolic-extract-from-leaves-of-rubus-imperialis-in-dss-induced-colitis-in-mice
#6
Luisa Mota da Silva, Lincon Bordignon Somensi, Thaise Boeing, Cristiane Barp, Valdir Cechinel-Filho, Rivaldo Niero, Sérgio Faloni de Andrade
This study investigated the effects of Rubus imperialis, a berry known as "amora-branca", in colitis dextran sulfate sodium (DSS)-induced in mice. Animals were treated orally with vehicle (water), 5-aminosalicylic acid (100 mg/kg) or methanolic extract from leaves of R. imperialis (MERI, 100 mg/kg), once a day during seven days. The disease activity index (DAI) was observed daily. Colons were collected for histological, histochemical and biochemical analysis. The administration of MERI exacerbated colitis, as indicated by DAI heightened weight loss and increased histological colonic injury...
October 31, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27796723/our-silver-jubilee-anniversary-1991-2016
#7
EDITORIAL
Michael Whitehouse
No abstract text is available yet for this article.
October 28, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27778200/ameliorating-chronic-pain-opioids-adjunct-and-alternative-therapies
#8
M C Powanda, P J Berry, K D Rainsford
No abstract text is available yet for this article.
October 24, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27766505/proper-balance-of-omega-3-and-omega-6-fatty-acid-supplements-with-topical-cyclosporine-attenuated-contact-lens-related-dry-eye-syndrome
#9
Ling Wang, Xi Chen, Jingfang Hao, Lu Yang
Essential fatty acids had been applied in the treatment of dry eye syndrome (DES), but the effects of different combinations of fatty acids have not been investigated. 360 long-term contact lens wearers were included in this double-blinded study. Omega-3 and omega-6 fatty acids were combined in different ratios and supplied to the participants that were randomly divided into six groups, and the effects of different essential fatty acids mixture on DES with or without topical cyclosporine were investigated. More than half of long-term contact lens wearers suffered from DES, which were found to be attenuated by oral supplement of properly balanced O3FA and O6FA fatty acid...
October 20, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27766504/curcumin-inhibits-paraquat-induced-lung-inflammation-and-fibrosis-by-extracellular-matrix-modifications-in-mouse-model
#10
Namitosh Tyagi, D Dash, Rashmi Singh
OBJECTIVE: Paraquat (PQ), a potent herbicide can cause severe toxicity. We report here that fibroproliferation phase of acute lung injury (ALI) is initiated much earlier (within 48 h) after PQ intoxication than previously reported (after 2 weeks) and we aimed to study the protective effects of intranasal curcumin as new therapeutic strategy in mouse model. METHODS: Mice (Park's strain) were divided into five experimental groups (I) control, received only saline (0...
October 20, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27761693/curcuma-longa-extract-reduces-inflammatory-and-oxidative-stress-biomarkers-in-osteoarthritis-of-knee-a-four-month-double-blind-randomized-placebo-controlled-trial
#11
Shobhit Srivastava, Anil K Saksena, Sanjay Khattri, Santosh Kumar, Raghubendra Singh Dagur
BACKGROUND AND PURPOSE: Curcuma longa L. (CL), an Indian herb, has been used to treat many disorders because of its wide spectrum of pharmacological activities. It has been shown to exhibit anti-oxidant and anti-inflammatory properties, and is being used as herbal remedy since ancient times. Osteoarthritis of knee (KOA) is a chronic painful disorder in which prolong use of non-steroidal anti-inflammatory drugs (NSAIDs) or steroids may result into many serious side effects; hence, there is a need to develop herbal drugs, having good analgesia without side effects...
October 19, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27757590/niflumic-acid-a-trpv1-channel-modulator-ameliorates-stavudine-induced-neuropathic-pain
#12
Lovish Marwaha, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Rupinder Kaur Sodhi, Anurag Kuhad
TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this background, the present study was aimed to investigate the protective effect of niflumic acid, a TRPV1 modulator, on stavudine (STV)-induced neuropathic pain in rats. Stavudine (50 mg/kg) was administered intravenously via tail vein in rats to induce neuropathic pain...
October 18, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27757589/trp-channels-potential-drug-target-for-neuropathic-pain
#13
Lovish Marwaha, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Anurag Kuhad
Neuropathic pain is a debilitating disease which affects central as well as peripheral nervous system. Transient receptor potential (TRP) channels are ligand-gated ion channels that detect physical and chemical stimuli and promote painful sensations via nociceptor activation. TRP channels have physiological role in the mechanisms controlling several physiological responses like temperature and mechanical sensations, response to painful stimuli, taste, and pheromones. TRP channel family involves six different TRPs (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPA1) which are expressed in pain sensing neurons and primary afferent nociceptors...
October 18, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27738917/amelioration-of-oxidative-and-inflammatory-changes-by-swertia-chirayita-leaves-in-experimental-arthritis
#14
Harsha Lad, Deepak Bhatnagar
The present study was aimed to determine the therapeutic effects of Swertia chirayita leaves against oxidative and inflammatory injuries in Freund's complete adjuvant (FCA) induced arthritic rats. The extract was evaluated for its phytoconstituents and various invitro antioxidant properties followed by its in vivo effects. The hydroethanolic extract of S. chirayita leaves (SCE) was orally administered (200 mg/kg body weight, per day, p.o.) and the effect on the liver lipid peroxidation (LPO), antioxidant status, protein carbonyl formation along with the histopathology of liver were evaluated after induction of adjuvant arthritis...
October 14, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27761692/plausible-anti-inflammatory-mechanism-of-resveratrol-and-caffeic-acid-against-chronic-stress-induced-insulin-resistance-in-mice
#15
Suprithi Choudhary, Ashish Mourya, Swati Ahuja, Sangeeta Pilkhwal Sah, Anil Kumar
Stress is associated with many diseases and dysfunctions, such as depression, cardiovascular alterations, immunological function disorder, inflammation, obesity, and insulin resistance. Stress-induced inflammation is associated with the genesis of insulin resistance. Stress activates hypothalamic pituitary adrenal axis, Renin Angiotensin System pathway, and sympatho-adrenal system, all of which are involved in the production of cytokines, causing the negative downregulation of insulin signaling either by phosphorylating serine residues of IRS or by inhibiting the activity of Akt leading to insulin resistance...
December 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27682325/differences-between-serum-polar-lipid-profiles-of-male-and-female-rheumatoid-arthritis-patients-in-response-to-glucocorticoid-treatment
#16
Junzeng Fu, Bart V J Cuppen, Paco M J Welsing, Herman van Wietmarschen, Amy C Harms, Ruud Berger, Slavik Koval, Ruth D E Fritsch-Stork, Johannes W J Bijlsma, Thomas Hankemeier, Jan van der Greef, Floris P J G Lafeber
OBJECTIVE: As there are pharmacological differences between males and females, and glucocorticoid (GC) treatment is associated with increased cardiovascular mortality rate in rheumatoid arthritis (RA) patients, it is important to study serum polar lipid profiles of male and female patients in response to GC therapy. Gender differences may require an adjustment to the treatment strategy for a selection of patients. METHODS: Serum samples from 281 RA patients were analysed using a targeted lipidomics platform...
December 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27671331/pharmacological-studies-on-the-anti-inflammatory-and-immunomodulatory-role-of-pentoxifylline-and-its-interaction-with-nitric-oxide-no-in-experimental-arthritis-in-rats
#17
Rishi Pal, Manju J Chaudhary, Prafulla Chandra Tiwari, Rajendra Nath, Suresh Babu, Kamlesh Kumar Pant
AIM: Present study was designed to evaluate protective effects of pentoxifylline and its potentiation with low dose of nitric oxide (NO) modulators in adjuvant-induced experimental arthritis in rats. METHOD: Wistar rats (200-300 g, n = 8 per group) of both sexes were used in the study. On day "0" experimental arthritis was induced by injecting 0.2 ml of Complete Freund's adjuvant (CFA) in sub-planter region of right hind paw of animals. Pentoxifylline treatment alone and in combination with NO modulators was given (i...
October 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27671330/pharmacological-and-toxicological-evaluations-of-the-new-pyrazole-compound-lqfm-021-as-potential-analgesic-and-anti-inflammatory-agents
#18
Iziara F Florentino, Daiany P B da Silva, José Luís R Martins, Taciane S da Silva, Fernanda C A Santos, Carlos R Tonussi, Géssica A Vasconcelos, Boniek G Vaz, Luciano M Lião, Ricardo Menegatti, Elson A Costa
Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute and sub-chronic administration in rats submitted to a CFA-induced chronic arthritis model, as well as compare the toxicity of this compound to that of dipyrone, given throughout 7 days. Firstly, we observed that acute oral administration of the higher dose (130 µmol/kg) of LQFM-021 reduced paw lifting time (PET) and edema formation...
October 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27671329/%C3%AE-chymotrypsin-regulates-free-fatty-acids-and-uchl-1-to-ameliorate-n-methyl-nitrosourea-induced-mammary-gland-carcinoma-in-albino-wistar-rats
#19
Asha Rani, Subhadeep Roy, Manjari Singh, Uma Devi, Rajnish K Yadav, Swetlana Gautam, Jitendra K Rawat, Mohd Nazam Ansari, Abdulaziz S Saeedan, Anand Prakash, Gaurav Kaithwas
This study was undertaken to investigate the effect of α-chymotrypsin on methyl nitrosourea (MNU) induced mammary gland carcinoma in albino wistar rats. Animals were randomized into four groups (six animals in each). Group I (sham control 0.9 % normal saline p.o.); Group II (toxic control, MNU 47 mg/kg, i.v.); Group III (α-chymotrypsin, 5 mg/kg, p.o.); Group IV (α-chymotrypsin, 10 mg/kg p.o.). Toxicity was induced by single i.v. injection of MNU followed by α-chymotrypsin supplementation therapy for 100 days...
October 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27645902/lps-and-neuroinflammation-a-matter-of-timing
#20
Patricia C Lopes
Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology 10.1007/s10787-016-0274-3 , 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation...
October 2016: Inflammopharmacology
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