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Inflammopharmacology

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https://www.readbyqxmd.com/read/28447177/yeast-rna-extract-suppresses-human-osteoclast-resorption-in-vitro
#1
Melissa D Cantley, K D Rainsford, David R Haynes
AIMS: The aim of this short study was to test the combinations of RNA extracts (both the connective tissue extracts-cartilage and synovia along with yeast extract) found in natural ribonucleotide extract Osteochondrin S (OST) on human osteoclast formation and activity in vitro. METHODS: In vitro human osteoclasts were treated with the RNA extracts (cartilage, synovia and yeast) at concentrations equivalent to those in OST starting from day 7 of the culture. A tartrate resistant acid phosphatase stain (TRAP) was used to indicate osteoclast formation and activity assessed by determining area of dentine resorption...
April 26, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28429097/immunomodulatory-and-therapeutic-role-of-cinnamomum-verum-extracts-in-collagen-induced-arthritic-balb-c-mice
#2
Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum verum (CV), also known as 'Dalchini', is the dry bark of the Cinnamomum verum (L.) plant, and has been used as a traditional Pakistani medicine to alleviate pain and inflammation in patients suffering from arthritic rheumatism. It contains alkaloids, triterpenes, Cinnamaldehyde and other volatile oils. The aim of the present study was to investigate the underlying biological effect of ethyl alcohol (EtOH) and methyl alcohol (MeOH) extracts from CV on collagen type-II induced arthritic (CIA) mice...
April 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28417246/mammalian-target-of-rapamycin-mtor-as-a-potential-therapeutic-target-in-various-diseases
#3
REVIEW
Avileen Kaur, Saurabh Sharma
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that belongs to Phosphatidylinositol-3-kinase related kinase superfamily. The signaling pathways of mTOR are integrated through the protein complexes of mTORC1 and mTORC2. mTORC1 controls protein synthesis, cell growth, proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 seems to regulate cell survival and polarity. Dysregulation of the mTOR pathway has been implicated in the pathophysiology of a number of disease conditions, including cancer, cardiovascular, neurodegenerative, and various renal diseases...
April 17, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28409391/anti-inflammatory-activity-of-the-functional-groups-present-in-hippophae-rhamnoides-seabuckthorn-leaf-extract
#4
Himanshi Tanwar, Shweta, M Karthik Ananth, Divya Singh, S Narsimhan, Shashi Bala Singh, Lilly Ganju
ETHNO PHARMACOLOGICAL RELEVANCE: The study explores the anti-inflammatory activity of components present in fractions obtained from leaves of Hippophae rhamnoides in mouse peritoneal macrophages. AIM OF THE STUDY: Immunomodulators salvage the immune response by enhancing or reducing its capacity to the required level. Plant extracts are extensively used as immunomodulators because of their easy availability, simple methods of preparation and minimum side effects with maximum efficacy...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28409390/dynamin-related-protein-1-as-potential-therapeutic-target-in-various-diseases
#5
REVIEW
Surinder Singh, Saurabh Sharma
Mitochondria can interchange morphology due to their dynamic nature. It can exist in either fragmented disconnected arrangement or elongated interconnected mitochondrial networks due to fission and fusion, respectively. The recent studies have revealed the remarkable and unexpected insights into the physiological impact and molecular regulation of mitochondrial morphology. The balance between fission and fusion governs the faith of the cell. The active targeting of DRP 1 to the outer mitochondrial membrane (OMM) is done by non-GTPase receptor proteins such as mitochondrial fission factor, mitochondrial fission protein 1 and mitochondrial elongation factor 1...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28409389/curcumin-protects-dopaminergic-neurons-against-inflammation-mediated-damage-and-improves-motor-dysfunction-induced-by-single-intranigral-lipopolysaccharide-injection
#6
Neha Sharma, Sheetal Sharma, Bimla Nehru
Various studies have indicated a lower incidence and prevalence of neurological conditions in people consuming curcumin. The ability of curcumin to target multiple cascades, simultaneously, could be held responsible for its neuroprotective effects. The present study was designed to investigate the potential of curcumin in minimizing microglia-mediated damage in lipopolysaccharide (LPS) induced model of PD. Altered microglial functions and increased inflammatory profile of the CNS have severe behavioral consequences...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28409388/diethylcarbamazine-attenuates-the-expression-of-pro-fibrogenic-markers-and-hepatic-stellate-cells-activation-in-carbon-tetrachloride-induced-liver-fibrosis
#7
Maria Eduarda Rocha de França, Sura Wanessa Santos Rocha, Wilma Helena Oliveira, Laise Aline Santos, Anne Gabrielle Vasconcelos de Oliveira, Karla Patrícia Sousa Barbosa, Ana Karolina Santana Nunes, Gabriel Barros Rodrigues, Deniele Bezerra Lós, Christina Alves Peixoto
BACKGROUND AND AIM: While diethylcarbamazine citrate (DEC) displays important anti-inflammatory effects in experimental models of liver injury, the mechanisms of its action remain poorly understood. The aim of the present study was to investigate the fibrolytic potential of DEC. METHODS: Mice receive two injections of carbon tetrachloride (CCl4) per week for 8 weeks. DEC 50 mg/kg body weight was administered through drinking water during the last 12 days of liver injury...
April 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28391389/combination-therapy-with-omega-3-fatty-acids-plus-tamsulocin-and-finasteride-in-the-treatment-of-men-with-lower-urinary-tract-symptoms-luts-and-benign-prostatic-hyperplasia-bph
#8
Alireza Ghadian, Mehran Rezaei
PURPOSE: Inflammation and Cyclooxygenase-2 (COX-2) as a part of it are common in BPH specimens and may play a role in the pathogenesis of the disease through cytokines that promote cell growth or lead to smooth muscle contraction. The aim of this study is to analyze whether combination therapy with omega-3 fatty acids, which have anti-inflammatory and COX-2 inhibitory effects, and tamsulocin plus finasteride offers an advantage compared to tamsulocin plus finasteride therapy in patients with BPH...
April 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28389995/cardiovascular-effect-of-inflammation-and-nonsteroidal-anti-inflammatory-drugs-on-renin-angiotensin-system-in-experimental-arthritis
#9
Waheed Asghar, Ali Aghazadeh-Habashi, Fakhreddin Jamali
A co-morbidity of inflammatory conditions is increased cardio-renal risks. Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) which are used to treat pain and inflammation are also associated with increase in such risks. We hypothesized that inflammation and NSAIDs impose the cardio-renal risk through the activation of the renin-angiotensin-system (RAS), a regulating pathway of the renal and cardiovascular homeostasis. We investigated the effect of adjuvant arthritis and NSAIDs on the RAS. Western blotting and ELISA were used to measure the RAS components...
April 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28378280/efficacy-of-phenyl-quinoline-phenol-derivatives-as-cox-2-inhibitors-an-approach-to-emergent-the-small-molecules-as-the-anti-inflammatory-and-analgesic-therapeutics
#10
A Manikandan, S Ravichandran, K I Sathiyanarayanan, A Sivakumar
2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC50 0.026 µM) and 4j (IC50 0.102 µM) were found as most potent COX-2 inhibitors. Consequently, to get more insight into the binding mode with COX-2, compounds 4a-l were docked into the COX-2 (PDB ID: 1CX2) active site. In the Human Red Blood Cells (HRBC) membrane stabilization assay (in vitro anti-inflammatory), compounds 4f (IC50 0...
April 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28365854/inhibitory-effects-of-dioscin-on-atherosclerosis-and-foam-cell-formation-in-hyperlipidemia-rats
#11
Ping Wang, Li-Ya He, Guo-Dong Shen, Rui-Lin Li, Jun-Li Yang
Macrophage-derived foam cells are well known for their key role in development of atherosclerosis (AS). The present study aimed to examine whether dioscin exerts anti-atherosclerotic activity and inhibits foam cell formation. A high-fat induced AS model and ox-LDL treated macrophages were established and received treatment of dioscin. Anti-atherosclerotic activity in vivo was assessed by atherosclerotic lesions size and aortic lipid contents. Macrophage formed foam cells were positively identified by oil red o staining...
April 1, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28353125/potential-drug-targets-and-treatment-of-schizophrenia
#12
REVIEW
Anil Kumar, Monu Yadav, Milind Parle, Sameer Dhingra, Dinesh K Dhull
Schizophrenia is one of the most prevalent chronic psychiatric disorders that affect 1% of the world's population. Despite its societal burden, pathophysiology of schizophrenia remains poorly understood. Currently available drugs predominantly control positive symptoms, and often have no or poor control on negative and related cognitive symptoms, which strongly affect functional outcome in schizophrenia. The present article is an attempt to provide a critical review of recent hypothesis to understand pathophysiology of schizophrenia and to highlight exploitable molecular drug targets other than dopaminergic systems to treat and manage schizophrenia effectively...
March 28, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28353124/nrf2-a-potential-therapeutic-target-for-diabetic-neuropathy
#13
REVIEW
Anil Kumar, Ruchika Mittal
Different aspects involved in pathophysiology of diabetic neuropathy are related to inflammatory and apoptotic pathways. This article summarizes evidence that Nrf2 acts as a bridging link in various inflammatory and apoptotic pathways impacting progression of diabetic neuropathy. Nrf2 is involved in expression of various antioxidant proteins (such as detoxifying enzymes) via antioxidant response element (ARE) binding site. Under normal conditions, Nrf2 is inactive and remains in the cytosol. Hyperglycemia is a strong stimulus for oxidative stress and inflammation that downregulates the activity of Nrf2 through various neuroinflammatory pathways...
March 28, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28337639/the-impact-of-mangiferin-from-belamcanda-chinensis-on-experimental-colitis-in-rats
#14
Marta Szandruk, Anna Merwid-Ląd, Adam Szeląg
BACKGROUND: Inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)] constitutes an important clinical problem. The pathogenesis of IBD remains unclear. It is believed that immune dysfunction, inflammatory mediators and oxidative damage play crucial roles in development of IBD. The condition is clinically associated with symptoms ranging from mild to severe during relapses, depending on the affected segment of the gastrointestinal tract. Bloody diarrhea with mucus, abdominal pain, weight loss and anemia are initial symptoms of both CD and UC...
March 24, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28303368/tramadol-differentially-regulates-m1-and-m2-macrophages-from-human-umbilical-cord-blood
#15
Jun Zhang, Liang Chen, Yunyun Sun, Yuanhai Li
Tramadol is an analgesic drug and relieves pain through activating μ-opioid receptors and inhibiting serotonin and noradrenaline reuptake. Emerging evidence shows that it also stimulates immune cells, including NK cells, splenocytes, and lymphocytes, and elevates IL-2 production. However, it remains unknown whether and how tramadol directly affects macrophages. To answer these questions, we collected human umbilical cord blood, isolated macrophages, and examined their responses to tramadol. Although tramadol did not alter resting macrophages and the antigen-presenting function in lipopolysaccharide-activated macrophages, it regulated M1 and M2 macrophages, which are, respectively, transformed by IFN-γ and IL-4...
March 17, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28289922/curcumin-inhibits-lipopolysaccharide-lps-induced-endotoxemia-and-airway-inflammation-through-modulation-of-sequential-release-of-inflammatory-mediators-tnf-%C3%AE-and-tgf-%C3%AE-1-in-murine-model
#16
Asha Kumari, D Dash, Rashmi Singh
OBJECTIVE: Curcumin (diferuloylmethane), a major component of turmeric is well known for its anti-inflammatory potential. Present study investigates sequential release of inflammatory mediators post LPS challenge (10 mg/kg,i.p.) causing lung inflammation and its modulation by curcumin through different routes (20 mg/kg, i.p and 10 mg/kg, i.n.) in murine model. Dexamethasone (1 mg/kg, i.p) was used as standard drug. METHODS: Lung Inflammation was evaluated by histopathological analysis, myeloperoxidase (MPO) activity followed by inflammatory cell count and total protein content measurements in bronchoalveolar fluid (BALF)...
March 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28280964/evaluation-of-the-protective-effect-of-pentoxifylline-on-carrageenan-induced-chronic-non-bacterial-prostatitis-in-rats
#17
Mahboobeh Hajighorbani, Mahmood Ahmadi-Hamedani, Elaheh Shahab, Farzad Hayati, Khatereh Kafshdoozan, Keivan Keramati, Amin Hossein Amini
Chronic non-bacterial prostatitis (CNP) is the most common type of prostatitis and oxidative stress (OS) was shown to be highly elevated in prostatitis patients. This study aimed to investigate the protective effect of pentoxifylline (PTX) on CNP induced by carrageenan in rats. Male adult Wistar rats (n = 30) were divided into control, CNP and three treatment groups (n = 6) including CNP + cernilton and CNP + PTX groups. CNP was induced by single intraprostatic injection of 1% carrageenan (100 µl)...
March 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28265836/pro-inflammatory-cytokines-involvement-in-the-hesperidin-antihyperalgesic-effects-at-peripheral-and-central-levels-in-a-neuropathic-pain-model
#18
A I Carballo-Villalobos, M E González-Trujano, N Alvarado-Vázquez, F J López-Muñoz
Emerging evidence proposes a link between immune changes and pain, which is consistent with the inflammation theory and the increased incidence of neurodegenerative diseases. Flavonoids have long been used because of their anti-inflammatory potential activity and they are considered a promising alternative to alleviate neuropathic pain. The aim of this study was to investigate the antihyperalgesic effect of hesperidin and the presence of pro-inflammatory cytokines evaluated at peripheral and central levels in the chronic constriction injury as model of neuropathic pain in rats...
March 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28258522/sitagliptin-and-liraglutide-reversed-nigrostriatal-degeneration-of-rodent-brain-in-rotenone-induced-parkinson-s-disease
#19
Ghada A Badawi, Mai A Abd El Fattah, Hala F Zaki, Moushira I El Sayed
The present study investigated the possible relationship between pro-inflammatory cytokines and programmed nigral neuronal death in rotenone model of Parkinson's disease (PD). Sitagliptin and liraglutide efficacy to inhibit the inflammatory-apoptotic degenerative process were investigated, too. The experimental PD were induced in male albino rats by ten subcutaneously injections of rotenone (3 mg/kg/day, s.c). All treatment drugs were administered for 16 days after induction of Parkinson rat's model. Sitagliptin and liraglutide were administered in three different dose levels (10-20-30 mg/kg, p...
March 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28255738/cyclophosphamide-induced-stomach-and-duodenal-lesions-as-a-no-system-disturbance-in-rats-l-name-l-arginine-stable-gastric-pentadecapeptide-bpc-157
#20
Krešimir Luetic, Mario Sucic, Josipa Vlainic, Zeljka Belosic Halle, Dean Strinic, Tinka Vidovic, Franka Luetic, Marinko Marusic, Sasa Gulic, Tatjana Turudic Pavelic, Antonio Kokot, Ranka Serventi Seiwerth, Domagoj Drmic, Lovorka Batelja, Sven Seiwerth, Predrag Sikiric
We revealed a new point with cyclophosphamide (150 mg/kg/day intraperitoneally for 7 days): we counteracted both rat stomach and duodenal ulcers and increased NO- and MDA-levels in these tissues. As a NO-system effect, BPC 157 therapy (10 µg/kg, 10 ng/kg, intraperitoneally once a day or in drinking water, till the sacrifice) attenuated the increased NO- and MDA-levels and nullified, in rats, severe cyclophosphamide-ulcers and even stronger stomach and duodenal lesions after cyclophosphamide + L-NAME (5 mg/kg intraperitoneally once a day)...
March 2, 2017: Inflammopharmacology
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