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Inflammopharmacology

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https://www.readbyqxmd.com/read/28220389/polymorphisms-in-key-bone-modulator-cytokines-genes-influence-bisphosphonates-therapy-in-postmenopausal-women
#1
C A D Lima, N R Javorski, A P O Souza, A D Barbosa, A P M C Valença, S Crovella, P R E Souza, J De Azevedo Silva, P Sandrin-Garcia
Osteoporosis is a multifactorial and debilitating disease resulting from decreased bone mineral density (BMD) and loss of tissue microarchitecture. Ineffective therapies may lead to bone fractures and subsequent death. Single nucleotide polymorphisms (SNPs) in key immune regulator genes have been associated with therapeutic response to bisphosphonates, which are the first therapeutic line of choice for osteoporosis. However, cytokine pathways and their relation with therapeutic adhesion remain to be fully elucidated...
February 21, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28210905/hypermagnesemia-disturbances-in-rats-no-related-pentadecapeptide-bpc-157-abrogates-l-name-and-l-arginine-worsen
#2
Maria Medvidovic-Grubisic, Vasilije Stambolija, Danijela Kolenc, Jadranka Katancic, Tamara Murselovic, Ivna Plestina-Borjan, Sanja Strbe, Domagoj Drmic, Ivan Barisic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
AIM: Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization. Moreover, this might be an NO-system-related effect. Previously, BPC 157 counteracts paralysis, arrhythmias and hyperkalaemia, extreme muscle weakness; parasympathetic and neuromuscular blockade; injured muscle healing and interacts with the NOS-blocker and NOS-substrate effects...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28210904/acute-and-neuropathic-orofacial-antinociceptive-effect-of-eucalyptol
#3
José de Maria de Albuquerque de Melo Júnior, Marina de Barros Mamede Vidal Damasceno, Sacha Aubrey Alves Rodrigues Santos, Talita Matias Barbosa, João Ronielly Campêlo Araújo, Antonio Eufrásio Vieira-Neto, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima-Júnior, Adriana Rolim Campos
Terpenes have a wide range of pharmacological properties, including antinociceptive action. The anti-inflammatory and antinociceptive effects of eucalyptol are well established. The purpose of this study was to evaluate the antinociceptive effect of eucalyptol on acute and neuropathic orofacial pain in rodent models. Acute orofacial and corneal nociception was induced with formalin, capsaicin, glutamate and hypertonic saline in mice. In another series, animals were pretreated with capsazepine or ruthenium red to evaluate the involvement of TRPV1 receptors in the effect of eucalyptol...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28197798/inhibition-of-proinflammatory-pathways-by-bioactive-fraction-of-tinospora-cordifolia
#4
Jenny Jacob, Bashi M Babu, Mohind C Mohan, A P Abhimannue, B Prakash Kumar
Tinospora cordifolia (Willd.) Miers ex Hook. f. & Thomson, a known immunomodulatory agent extensively used in ayurveda, has not been effectively validated for the mechanisms involved in immunomodulation and the identification of the active principles. The bioactive fraction of T. cordifolia (TBF) in methanol was used for nitric oxide (NO) radical scavenging activity, lipoxygenase (LOX) and cyclooxygenase (COX) dual inhibition and cytotoxicity studies. Production of the proinflammatory cytokines, tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in dendritic cell (DC) suspensions treated with lipopolysaccharide (LPS) was also studied...
February 15, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28194545/to-stop-the-erosion-of-hope-the-dmard-category-and-the-place-of-semantics-in-modern-rheumatology
#5
Jonas Kure Buer
The category of disease-modifying anti-rheumatic drugs (DMARDs) emerged in the 1970s to describe drugs capable of altering the long-term destructive course of arthritis. It became a core concept in rheumatology's reorientation towards pharmaceuticals in the late twentieth century. By examining the earliest use of the term "disease-modifying" in scientific publications, this paper identifies the drugs that the category described when it first emerged. Leaning on systematic reviews of each of these drugs towards the end of their career in rheumatology, it then establishes that posterity would not recognize any of these early DMARDs as capable of altering the long-term course of the disease...
February 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28190128/ultraviolet-b-decreases-dna-methylation-level-of-cd4-%C3%A2-t-cells-in-patients-with-systemic-lupus-erythematosus
#6
Min Zhang, Xuan Fang, Guo-Sheng Wang, Yan Ma, Li Jin, Xiao-Mei Li, Xiang-Pei Li
OBJECTIVE: In the present study, DNA methylation level of CD4+ T cells exposed to ultraviolet B (UVB) was investigated and its potential mechanisms were also explored. METHODS: CD4+ T cells from 12 cases of healthy subjects and 33 cases of SLE patients were isolated and exposed to different dosages (0, 50, 100 mJ/cm(2)) of UVB. Further, SLE patients were divided into two groups: active SLE group (22 cases, SLEDAI scores >4) and inactive SLE group (11 cases, SLEDAI scores ≤4)...
February 11, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28176199/effects-of-antirheumatic-drug-underutilization-on-rheumatoid-arthritis-disease-activity
#7
Mohammad A Y Alqudah, Sayer Al-Azzam, Karem Alzoubi, Mohammad Alkhatatbeh, Khaldoon Alawneh, Ola Alazzeh, Bayan Ababneh
BACKGROUND: Following the recommended guidelines is crucial for achieving patient remission in rheumatoid arthritis. The aim of this study was to assess the effect of proper drug utilization of antirheumatic drugs on disease activity and drug safety in Jordan. METHODS: In a retrospective cross-sectional study, patient's demographics, clinical variables, drug regimens and side effects were recorded and the 28-joint disease activity scores were calculated. Patients were stratified into high, moderate, low disease activity or remission group...
February 8, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28176198/constituents-of-leaves-from-bauhinia-curvula-benth-exert-gastroprotective-activity-in-rodents-role-of-quercitrin-and-kaempferol
#8
Ana Paula Beber, Priscila de Souza, Thaise Boeing, Lincon Bordignon Somensi, Luísa Nathália Bolda Mariano, Benhur Judah Cury, Ligia Moura Burci, Cristiane Bezerra da Silva, Euclésio Simionatto, Sérgio Faloni de Andrade, Luísa Mota da Silva
The Bauhinia genus is known as "Pata-de-Vaca" and a wide variety of these species are used in Brazilian folk medicine due to their gastroprotective properties. This study aimed to investigate the antiulcer efficacy of the hydroalcoholic extract from B. curvula (HEBC) leaves, as well as its semi-purified fraction (SPFr) and the contribution of their phytochemicals constituents for this effect. For that, ethanol 60%/HCl 0.3 M- and indomethacin-induced gastric ulcer were performed in rodents. Gastric ulcerated tissues were processed for histological, histochemical and biochemical analysis...
February 7, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28168553/ccr2-contributes-to-the-recruitment-of-monocytes-and-leads-to-kidney-inflammation-and-fibrosis-development
#9
Tarcio Teodoro Braga, Matheus Correa-Costa, Reinaldo Correia Silva, Mario Costa Cruz, Meire Ioshie Hiyane, Joao Santana da Silva, Katia Regina Perez, Iolanda Midea Cuccovia, Niels Olsen Saraiva Camara
Chemokines are a large family of proteins that, once associated to its receptor on leukocytes, stimulate their movement and migration from blood to tissues. Once in the tissue, immune cells trigger inflammation that, when uncontrolled, leads to fibrosis development. Among the immune cells, macrophages take a special role in fibrosis formation, since macrophage depletion reflects less collagen deposition. The majority of tissue macrophages is derived from monocytes, especially monocytes expressing the chemokine receptor CCR2...
February 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28168552/obesity-cardiovascular-disease-and-role-of-vitamin-c-on-inflammation-a-review-of-facts-and-underlying-mechanisms
#10
REVIEW
Mohammed S Ellulu
Obesity means the accumulation of excessive fat that may interfere with the maintenance of optimal state of health. Obesity causes cardiac and vascular disease through well-known mediators such as hypertension, type-2 diabetes mellitus, and dyslipidemia, but there are evidences for other mediators such as chronic inflammation, oxidative stress, and thrombosis. The decreased levels of antioxidants factors and nitric oxide predispose to further cardiovascular adverse events. To reduce the risks, antioxidants can help by neutralizing the free radicals and protecting from damage by donating electrons...
February 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28160128/blockade-of-the-kinin-b1-receptor-affects-the-cytokine-chemokine-profile-in-rat-brain-subjected-to-autoimmune-encephalomyelitis
#11
Karolina Podsiadło, Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Lidia Strużyńska
Kinins are bioactive peptides which provide multiple functions, including critical regulation of the inflammatory response. Released during tissue injury, kinins potentiate the inflammation which represents a hallmark of numerous neurological disorders, including those of autoimmune origin such as multiple sclerosis (MS). In the present work, we assess the expression of B1 receptor (B1R) in rat brain during the course of experimental autoimmune encephalomyelitis (EAE) which is an animal model of MS. We apply pharmacological inhibition to investigate the role of this receptor in the development of neurological deficits and in shaping the cytokine/chemokine profile during the course of the disease...
February 3, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28155119/a-combination-of-probiotics-and-magnesium-orotate-attenuate-depression-in-a-small-ssri-resistant-cohort-an-intestinal-anti-inflammatory-response-is-suggested
#12
Matthew Bambling, Sophie C Edwards, Sean Hall, Luis Vitetta
Approximately, one-third of those who develop major depression will have a poor response to treatment and over time can become treatment resistant. Intestinal dysbiosis has been implicated in depression with systemic inflammation and vagal and enteric nerve impairment. We report on a sequel pilot study (n = 12) with a combination probiotics/magnesium orotate formulation adjuvant administered with SSRIs for treatment resistant depression. At the end of an 8-week intervention mean changes for depression scores and quality of life in the group was clinically significantly improved (p < 0...
February 2, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28155120/novel-glycoside-from-wedelia-calendulacea-inhibits-diethyl-nitrosamine-induced-renal-cancer-via-downregulating-the-cox-2-and-peg2-through-nuclear-factor-%C3%AE%C2%BAb-pathway
#13
Amita Verma, Bahar Ahmed, Firoz Anwar, Mahfoozur Rahman, Dinesh Kumar Patel, Gaurav Kaithwas, Ravi Rani, Prakash C Bhatt, Vikas Kumar
A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN) (200 mg/kg) and ferric nitrilotriacetate (Fe-NTA) (9 mg/kg) were used for induction of renal cell carcinoma (RCC) in the rats. The rats were further divided into different groups and were treated with HEG doses for 22 weeks...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28155118/antinociceptive-interaction-of-gabapentin-with-minocycline-in-murine-diabetic-neuropathy
#14
H F Miranda, F Sierralta, V Jorquera, P Poblete, J C Prieto, V Noriega
OBJECTIVE: Diabetic neuropathy (DN) is the most common complication of diabetes and pain is one of the main symptoms of diabetic neuropathy, however, currently available drugs are often ineffective and complicated by adverse events. The purpose of this research was to evaluate the antinociceptive interaction between gabapentin and minocycline in a mice experimental model of DN by streptozocin (STZ). METHODS: The interaction of gabapentin with minocycline was evaluated by the writhing and hot plate tests at 3 and 7 days after STZ injection or vehicle in male CF1 mice...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28083748/antioxidant-and-anti-inflammatory-effects-of-zinc-zinc-dependent-nf-%C3%AE%C2%BAb-signaling
#15
REVIEW
Magdalena Jarosz, Magdalena Olbert, Gabriela Wyszogrodzka, Katarzyna Młyniec, Tadeusz Librowski
Zinc is a nutritionally fundamental trace element, essential to the structure and function of numerous macromolecules, including enzymes regulating cellular processes and cellular signaling pathways. The mineral modulates immune response and exhibits antioxidant and anti-inflammatory activity. Zinc retards oxidative processes on a long-term basis by inducing the expression of metallothioneins. These metal-binding cysteine-rich proteins are responsible for maintaining zinc-related cell homeostasis and act as potent electrophilic scavengers and cytoprotective agents...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28078497/anti-inflammatory-effect-of-naravelia-zeylanica-dc-via-suppression-of-inflammatory-mediators-in-carrageenan-induced-abdominal-oedema-in-zebrafish-model
#16
Sanmuga Priya Ekambaram, Senthamil Selvan Perumal, Selvaranjani Pavadai
The traditional herbal medicines are receiving great importance in the health care sector, especially in Indian system of medicine, i.e, Ayurveda. The present study focused on the standardization of Naravelia zeylanica (L.) DC in terms of its active phytochemicals and to evaluate the anti-inflammatory activity of ethanol extract of N. zeylanica (ENZ). An analytical method was developed by high-performance liquid chromatography for simultaneous determination of β-sitosterol, lupeol and oleanolic acid in ENZ...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28063133/a-clinical-and-safety-review-of-paracetamol-and-ibuprofen-in-children
#17
REVIEW
Dipak J Kanabar
The antipyretic analgesics, paracetamol, and non-steroidal anti-inflammatory agents NSAIDs are one of the most widely used classes of medications in children. The aim of this review is to determine if there are any clinically relevant differences in safety between ibuprofen and paracetamol that may recommend one agent over the other in the management of fever and discomfort in children older than 3 months of age.
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28054242/anti-nociceptive-and-anti-inflammatory-actions-of-sulforaphane-in-chronic-constriction-injury-induced-neuropathic-pain-mice
#18
Cheng Wang, Congpin Wang
Neuropathic pain is still considered as incurable disease as current therapies are not ideal in terms of efficacy and tolerability. It is imperative to search for novel drugs to obtain better treatments. Sulforaphane (SFN), a derivative of glucoraphanin present in cruciferous vegetables, exhibits therapeutic effects on inflammation-related diseases. Since inflammation plays an important role in regulating chronic pain, in the present study, we investigated anti-nociceptive effects of SFN and its underlying mechanisms in a neuropathic pain mouse model, sciatic nerve chronic constriction injury (CCI)...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28050757/implication-of-nrf2-ho-1-pathway-in-the-coloprotective-effect-of-coenzyme-q10-against-experimentally-induced-ulcerative-colitis
#19
Ahmed E Khodir, Hoda Atef, Eman Said, Hassan A ElKashef, Hatem A Salem
PURPOSE: Given the increased incidence of ulcerative colitis worldwide, the current study was designed to investigate the coloprotective potential of CoQ10 against experimentally induced ulcerative colitis (UC) and specify the implicated mechanisms. METHODS: Ulcerative colitis was induced by intracolonic instillation of [2 ml, 3% v/v acetic acid (AA)]. Rats in the different experimental groups received CoQ10 (10 or 30 and 100 mg/kg, orally) for eight consecutive days, either in a protective or curative regimen...
February 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28044215/mixed-effects-of-caffeic-acid-phenethyl-ester-cape-on-joint-inflammation-bone-loss-and-gastrointestinal-inflammation-in-a-murine-model-of-collagen-antibody-induced-arthritis
#20
Bonnie Williams, Eleni Tsangari, Romany Stansborough, Victor Marino, Melissa Cantley, Anak Dharmapatni, Rachel Gibson, Egon Perilli, Tania Crotti
OBJECTIVE: To investigate the effect of caffeic acid phenethyl ester (CAPE) on local and systemic inflammation and bone loss in collagen antibody-induced arthritis (CAIA) mice. METHODS: Four groups of mice (n = 8 per group) were allocated; control, CAPE (1 mg/kg), CAIA and CAIA + CAPE (1 mg/kg). Local inflammation and bone loss were evaluated using clinical paw scores, in vivo micro-computed tomography (micro-CT), histological assessment and tartrate-resistant acid phosphatase (TRAP) staining...
February 2017: Inflammopharmacology
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