journal
MENU ▼
Read by QxMD icon Read
search

Reviews in Medical Virology

journal
https://www.readbyqxmd.com/read/29345394/viruses-as-key-modulators-of-the-tgf-%C3%AE-pathway-a-double-edged-sword-involved-in-cancer
#1
REVIEW
Habibollah Mirzaei, Ebrahim Faghihloo
Transforming growth factor-β (TGF-β) signaling pathway is a key network in cell signaling that controls vital processes such as proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and migration, thus acting as a double-edged sword in normal development and diseases, in particular organ fibrosis, vascular disorders, and cancer. Early in tumorigenesis, the pathway exerts anti-tumor effects through suppressing cell cycle and inducing apoptosis, while during late stages, it functions as a tumor promoter by enhancing tumor invasiveness and metastasis...
January 18, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29316047/parainfluenza-virus-5-vectored-vaccines-against-human-and-animal-infectious-diseases
#2
REVIEW
Zhenhai Chen
Parainfluenza virus 5 (PIV5), known as canine parainfluenza virus in the veterinary field, is a negative-sense, nonsegmented, single-stranded RNA virus belonging to the Paramyxoviridae family. Parainfluenza virus 5 is an excellent viral vector and has been used as a live vaccine for kennel cough for many years in dogs without any safety concern. It can grow to high titers in many cell types, and its genome is stable even in the presence of foreign gene insertions. So far, PIV5 has been used to develop vaccines against influenza virus, respiratory syncytial virus, rabies virus, and Mycobacterium tuberculosis, demonstrating its ability to elicit robust and protective immune responses in preclinical animal models...
January 5, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29282795/interplay-of-foot-and-mouth-disease-virus-with-cell-mediated-and-humoral-immunity-of-host
#3
REVIEW
Muhammad Abubakar, Shumaila Manzoor, Afshan Ahmed
Foot and mouth disease virus (FMDV) causes a communicable disease of cloven hoofed animals, resulting in major economic losses during disease outbreaks. Like other members of the Picornaviridae FMDV has a relatively short infectious cycle; initiation of infection and dissemination, with production of infectious virions occurs in less than a week. The components of innate immunity as well as cell-mediated and humoral immunity play a crucial role in control of FMDV. However, it has been shown in vitro using a mouse model that FMDV has evolved certain mechanisms to counteract host immune responses ensuring its survival and spread...
December 28, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29272060/immunity-against-hepatitis-e-virus-infection-implications-for-therapy-and-vaccine-development
#4
REVIEW
Mohamad S Hakim, Aqsa Ikram, Jianhua Zhou, Wenshi Wang, Maikel P Peppelenbosch, Qiuwei Pan
Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune-based therapies...
December 22, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29218769/current-status-on-the-development-of-pseudoviruses-for-enveloped-viruses
#5
REVIEW
Qianqian Li, Qiang Liu, Weijin Huang, Xuguang Li, Youchun Wang
Emerging and reemerging infectious diseases have a strong negative impact on public health. However, because many of these pathogens must be handled in biosafety level, 3 or 4 containment laboratories, research and development of antivirals or vaccines against these diseases are often impeded. Alternative approaches to address this issue have been vigorously pursued, particularly the use of pseudoviruses in place of wild-type viruses. As pseudoviruses have been deprived of certain gene sequences of the virulent virus, they can be handled in biosafety level 2 laboratories...
December 7, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29210509/arboviruses-and-their-related-infections-in-china-a-comprehensive-field-and-laboratory-investigation-over-the-last-3-decades
#6
REVIEW
Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to the family Reoviridae...
December 6, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29210497/dengue-in-rio-grande-do-sul-brazil-2014-to-2016
#7
Tatiana Schaffer Gregianini, Gabriela Luchiari Tumioto-Giannini, Cátia Favreto, Luciana Ciarelli Plentz, Nilo Ikuta, Ana B Gorini da Veiga
The first autochthonous dengue case in Rio Grande do Sul (RS), Southern Brazil, occurred in 2007. In 2008 and 2009, only imported cases were reported in RS, but from 2010 to 2013, reports of autochthonous infections increased significantly. This study analyzes and discusses laboratory, demographic, and clinical data regarding dengue cases in RS, from 2014 to 2016. This study analyzed 13,420 serum samples from notified patients with suspicion of dengue fever in RS from 2014 to 2016. Seasonality of positive cases, viral serotypes, and clinical and epidemiological aspects were analyzed...
December 6, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29148608/criteria-to-define-interruption-of-transmission-of-human-cytomegalovirus-from-organ-donor-to-recipient
#8
REVIEW
Ilona Anna Baraniak, Matthew B Reeves, Paul D Griffiths
In this review article, we consider results suggesting that transmission of human cytomegalovirus (HCMV) from a donor of a solid organ to an immunologically naive individual can be reduced. Two randomized controlled trials have been conducted recently, one of active immunization of recipients pretransplant and another of passive immunization with monoclonal antibodies specific for HCMV given at the time of transplant. Although the available data are encouraging-providing evidence of a reduction in the incidence of HCMV viraemia-they fall short of what would be required to prove definitively that transmission has been completely prevented...
November 17, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29148605/an-overview-rabbit-hepatitis-e-virus-hev-and-rabbit-providing-an-animal-model-for-hev-study
#9
REVIEW
Lin Wang, Lin Liu, Ling Wang
Hepatitis E virus (HEV) is a single-stranded, positive-sense RNA virus and the causative agent of hepatitis E. The virus belongs to genus Orthohepevirus in the family Hepeviridae, which contains 4 major genotypes closely relating to humans. Genotypes 1 and 2 only infect humans whereas genotypes 3 and 4 HEV are harbored in a wide range of animal species worldwide and are zoonotic to humans. Recently, a novel animal strain of HEV has been isolated in farmed rabbits in China, and subsequently more strains were discovered in the rabbit populations in at least 7 other countries...
November 17, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29148108/human-pegivirus-hpgv-infection-in-sub-saharan-africa-a-call-for-a-renewed-research-agenda
#10
REVIEW
Shivank Singh, Jason T Blackard
The human pegivirus (HPgV)-formerly GB virus C-has a beneficial impact on HIV disease progression that has been described in multiple studies. Given the high prevalence of HIV in sub-Saharan Africa and the continuing need to suppress HIV replication, this review provides a comprehensive overview of the existing data on HPgV infection in sub-Saharan Africa, with a particular focus on studies of prevalence and the circulating HPgV genotypes. This review also highlights the need for additional studies of HPgV conducted on the African continent and proposes a research agenda for evaluation of HPgV...
November 17, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29143392/is-dr-von-magnus-to-blame-for-the-withdrawal-of-live-attenuated-influenza-vaccine
#11
EDITORIAL
P D Griffiths
No abstract text is available yet for this article.
November 15, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29135056/a-systematic-review-of-the-associations-between-hiv-hcv-coinfection-and-biomarkers-of-cardiovascular-disease
#12
REVIEW
Olatokunbo Osibogun, Oluseye Ogunmoroti, Erin D Michos, Erica S Spatz, Babatunde Olubajo, Khurram Nasir, Wasim Maziak
The incidence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection has been increasing with over 10 million people affected globally. The role biomarkers play as predictors of cardiovascular disease (CVD) risk among coinfected individuals is not well defined. We aimed to systematically review current evidence describing CVD biomarkers among individuals with HIV/HCV coinfection. We searched EMBASE, CINAHL, Google Scholar, PubMed, and Web of Science from inception to June 2017. MeSH terms and keywords were used to identify studies with information on HIV/HCV coinfection and CVD biomarkers (structural, functional, and serological) such as carotid intima-media thickness (CIMT), endothelial markers, C-reactive protein (CRP), homocysteine, and lipids...
November 14, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29143387/cytomegalovirus-is-still-in-intensive-care
#13
EDITORIAL
P D Griffiths
No abstract text is available yet for this article.
November 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29048711/rotavirus-virus-like-particles-rv-vlps-vaccines-an-update
#14
REVIEW
Harish Changotra, Avni Vij
Rotaviruses (RVs) cause over 0.2 million deaths annually and are reported to be the foremost cause of gastroenteritis in infants and children worldwide. Vaccination against RVs is the most successful and unsurpassed strategy to combat infection to date. Although the 2 current vaccines, Rotarix and RotaTeq, have dramatically reduced the disease burden, still there is a need for new vaccines. In this context, RV virus-like particles (RV-VLPs) represent potential vaccine candidates as they are noninfectious and effective nonreplicating immunogens that may reduce the risk of side effects related to the conventional vaccines...
November 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28905444/response-to-hepatitis-b-vaccination-in-patients-with-liver-cirrhosis
#15
REVIEW
Ioanna Aggeletopoulou, Panagiota Davoulou, Christos Konstantakis, Konstantinos Thomopoulos, Christos Triantos
Hepatitis B vaccination is strongly recommended for all infants and children but also for adults who are at risk of HBV infection. Attempts to immunize patients with liver cirrhosis have been proven relatively ineffective, and several strategies have already been used to improve the immune response in this group. The primary aim of this review is to examine, discuss, and summarize the immunogenicity of hepatitis B vaccination in patients with liver cirrhosis. MEDLINE search identified 11 studies (n = 961)...
November 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29047180/systematic-screening-of-viral-entry-inhibitors-using-surface-plasmon-resonance
#16
REVIEW
Penmetcha K R Kumar
Viral binding and entry into host cells for various viruses have been studied extensively, yielding a detailed understanding of the overall viral entry process. As cell entry is an essential and requisite process by which a virus initiates infection, it is an attractive target for therapeutic intervention. The advantages of targeting viral entry are an extracellular target site, relatively easy access for biological interventions, and lower toxicity. Several cell-based strategies and biophysical techniques have been used to screen compounds that block viral entry...
October 18, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29027728/hepatitis-in-aids-patients
#17
REVIEW
Muhammad Imran Qadir
The individuals with HIV infection are more susceptible to develop coinfections with infectious pathogens such as HCV and HBV. The routes of transmission of these pathogens are the same including sexual contact, injection drug use, or at birth from mother to an infant. The main reason of morbidity and mortality in HIV infected individuals is a liver disease in the context of antiretroviral therapy, and coinfection such as HCV and HBV complicates this condition. Nucleos(t)ide analogues are used for HBV infection management, and treatment of HCV infection is done by PegIFN and ribavirin combination and protease inhibitors...
October 13, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29024283/mechanisms-of-human-cytomegalovirus-infection-with-a-focus-on-epidermal-growth-factor-receptor-interactions
#18
REVIEW
Aline Semblano Carreira Falcão, Pedro Fernando da Costa Vasconcelos, Dorotéa de Fátima Lobato da Silva, João de Jesus Viana Pinheiro, Luiz Fábio Magno Falcão, Juarez Antonio Simões Quaresma
Human cytomegalovirus (HCMV) is a widespread opportunistic herpesvirus that causes severe diseases in immunocompromised individuals. It has a high prevalence worldwide that is linked with socioeconomic factors. Similar to other herpesviruses, HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. HCMV infects a broad range of cell types. This broad tropism suggests that it may use multiple receptors for host cell entry. The identification of receptors used by HCMV is essential for understanding viral pathogenesis, because these receptors mediate the early events necessary for infection...
October 11, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28929534/emerging-arboviruses-in-rio-grande-do-sul-brazil-chikungunya-and-zika-outbreaks-2014-2016
#19
Tatiana Schäffer Gregianini, Tani Ranieri, Cátia Favreto, Zenaida Marion Alves Nunes, Gabriela Luchiari Tumioto Giannini, Nara Druck Sanberg, Marilda Tereza Mar da Rosa, Ana Beatriz Gorini da Veiga
QUESTIONS INVESTIGATED: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures. DESIGN: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016...
September 20, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/28876496/seroprevalence-and-incidence-of-hepatitis-e-virus-among-blood-donors-a-review
#20
REVIEW
Duaa W Al-Sadeq, Amin F Majdalawieh, Gheyath K Nasrallah
Hepatitis E virus (HEV) is an RNA virus with 4 main genotypes. HEV-1 and HEV-2 infect solely humans, while HEV-3 and HEV-4 infect humans and various animals such as pigs, deer, and rabbits. HEV-5 and HEV-6 infect mainly wild boar. Recently, new genotypes, known as HEV-7 and HEV-8, were found to infect camels and humans. HEV is globally distributed into different epidemiological patterns based on socioeconomic factors and ecology. Although HEV is mainly transmitted through the fecal-oral route, it was also recognized as a transfusion-transmitted virus...
September 6, 2017: Reviews in Medical Virology
journal
journal
30845
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"