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Physiological Research

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https://www.readbyqxmd.com/read/28406707/moringa-oleifera-rich-diet-and-t-cell-calcium-signaling-in-hypertensive-rats
#1
E S Attakpa, N W Chabi, G A Bertin, J-M Ategbo, B Seri, N A Khan
Moringa oleifera is a plant whose fruits, roots and leaves have been advocated for traditional medicinal uses. The physico-chemical analysis shows that, Moringa contains more dietary polyunsaturated fatty acids (PUFA) than saturated fatty acids (SFA). The consumption of an experimental diet enriched with Moringa oleifera extracts lowered blood pressure in spontaneously hypertensive rats (SHR), but not in normotensive Wistar-Kyoto (WKY) rats as compared to rats fed an unsupplemented control diet. Anti-CD3-stimulated T-cell proliferation was diminished in both strains of rats fed the Moringa oleifera...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406706/nanofat-2-0-experimental-evidence-for-a-fat-grafting-rich-in-mesenchymal-stem-cells
#2
D Lo Furno, S Tamburino, G Mannino, E Gili, G Lombardo, M S Tarico, C Vancheri, R Giuffrida, R E Perrotta
Different strategies have been developed in the last decade to obtain fat grafts as rich as possible of mesenchymal stem cells, so exploiting their regenerative potential. Recently, a new kind of fat grafting, called "nanofat", has been obtained after several steps of fat emulsification and filtration. The final liquid suspension, virtually devoid of mature adipocytes, would improve tissue repair because of the presence of adipose mesenchymal stem cells (ASCs). However, since it is probable that many ASCs may be lost in the numerous phases of this procedure, we describe here a novel version of fat grafting, which we call "nanofat 2...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406705/tolerance-of-isolated-rabbit-hearts-to-short-ischemic-periods-is-affected-by-increased-lv-mass-fraction
#3
M Hlaváčová, V Olejníčková, M Ronzhina, T Stračina, O Janoušek, M Nováková, P Babula, J Kolářová, I Provazník, H Paulová
Hypertrophied hearts are known for increased risk of arrhythmias and are linked with reduced ischemic tolerance. However, still little is known about state characterized only by increased left ventricle (LV) mass fraction. Seventeen isolated rabbit hearts with various LV mass were divided into two groups according to LV weight/heart weight ratio (LVW/HW ratio), namely group H and L (with higher and lower LVW/HW ratio, respectively) and underwent three short cycles of global ischemia and reperfusion. The differences in electrogram (heart rate, QRS(max), mean number, onset and dominant form of ventricular premature beats) and in biochemical markers of myocardial injury (creatine kinase, lactate dehydrogenase - LDH) and lipid peroxidation (4-hydroxy-2-nonenal - 4-HNE) were studied...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406704/pro-inflammatory-gene-expression-in-adipose-tissue-of-patients-with-atherosclerosis
#4
S Čejková, I Králová Lesná, J Froněk, L Janoušek, A Králová, J Ždychová, R Poledne
Inflammatory changes, both in the arterial wall and adipose tissue, play a crucial role in the development of atherosclerosis. We measured the gene expression of tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and interleukin 6 (IL-6) in adipose tissue (AT) of living kidney donors (LKD) and patients with peripheral arterial disease (PAD). Quantitative polymerase chain reaction (qPCR) and flow cytometry analyses were performed in subcutaneous (SAT), visceral (VAT), and perivascular adipose tissue (PVAT)...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406703/chronic-administration-of-quercetin-induces-biomechanical-and-pharmacological-remodeling-in-the-rat-coronary-arteries
#5
A Monori-Kiss, F Kiss, J M Restifo, E Monos, G L Nadasy
Acute dilation brought about by the dietary flavonoid quercetin in coronary arterioles has been described earlier, but no information is available on its chronic effects. Male Wistar rats (body weight about 190 g) were divided to two groups: the quercetin-treated group (n=22) had quercetin supplementation of approximately 30 mg/kg/day, whereas the control group (n=20) had none. After eight weeks of treatment, intramural coronary arterioles with identical passive diameters (178+/-14 and 171+/-9 microm) were prepared and their biomechanics and pharmacological reactivities were tested using pressure arteriography ex vivo...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406702/an-alternatively-activated-macrophage-marker-cd163-in-severely-obese-patients-the-influence-of-very-low-calorie-diet-and-bariatric-surgery
#6
A Cinkajzlová, Z Lacinová, J Kloučková, P Kaválková, P Trachta, M Kosák, J Krátký, M Kasalický, K DoleŽalová, M Mráz, M Haluzík
CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406701/prompt-rise-in-urinary-ammonium-excretion-suffices-to-mitigate-metabolic-acidosis-in-an-experimental-animal-model-of-severe-normovolemic-hemodilution
#7
J K Teloh, I N Waack, H de Groot
Recently, we have established a model of severe stepwise normovolemic hemodilution to a hematocrit of 10% in rats employing three different colloidal volume replacement solutions (Voluven, Volulyte and Gelafundin) that are routinely used in clinical practice at present. We did not see severe dilutional acidosis as to be expected, but a decline in urinary pH. We here looked on further mechanisms of renal acid excretion during normovolemic hemodilution. Bicarbonate, which had been removed during normovolemic hemodilution, was calculated with the help of the Henderson-Hasselbalch equation...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406700/moderate-exercise-based-on-artificial-gravity-preserves-orthostatic-tolerance-and-exercise-capacity-during-short-term-head-down-bed-rest
#8
Xiao-Tao Li, Chang-Bin Yang, Yong-Sheng Zhu, Jing Sun, Fei Shi, Yong-Chun Wang, Yuan Gao, Jiang-Dong Zhao, Xi-Qing Sun
Numerous countermeasures have been proposed to minimize microgravity-induced physical deconditioning, but their benefits are limited. The present study aimed to investigate whether personalized aerobic exercise based on artificial gravity (AG) mitigates multisystem physical deconditioning. Fourteen men were assigned to the control group (n=6) and the countermeasure group (CM, n=8). Subjects in the CM group were exposed to AG (2Gz at foot level) for 30 min twice daily, during which time cycling exercise of 80-95% anaerobic threshold (AT) intensity was undertaken...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406699/early-morphologic-alterations-in-renal-artery-wall-and-renal-nerves-in-response-to-catheter-based-renal-denervation-procedure-in-sheep-difference-between-single-point-and-multiple-point-ablation-catheters
#9
M Táborský, D Richter, Z Tonar, T Kubíková, A Herman, J Peregrin, L Červenková, Z Husková, L Kopkan
Renal sympathetic hyperactivity is critically involved in hypertension pathophysiology; renal denervation (RDN) presents a novel strategy for treatment of resistant hypertension cases. This study assessed effects of two RDN systems to detect acute intravascular, vascular and peri-vascular changes in the renal artery, and renal nerve alterations, in the sheep. The procedures using a single-point or multi-point ablation catheters, Symplicity Flex(TM), Medtronic versus EnligHTN(TM), St. Jude Medical were compared; the intact contralateral kidneys served as controls...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406698/hematological-profile-of-untreated-or-ionizing-radiation-exposed-cyclooxygenase-2-deficient-mice
#10
M Hofer, Z Hoferová, L Dušek, K Souček, A Gruzdev
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with the dose of 4 Gy of gamma-rays and their wildtype littermates. At baseline, hematopoiesis was increased in COX-2-deficient mice, but attenuated by irradation in COX-2-deficient mice compared to wildtype. To conclude, the anti-inflammatory action of the COX-2 genetic disruption plays a positive role in hematopoiesis under basal conditions but is detrimental following radiation exposure...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406697/how-do-we-love-romantic-love-style-in-men-is-related-to-lower-testosterone-levels
#11
J Babková Durdiaková, P Celec, I Koborová, T Sedláčková, G Minárik, D Ostatníková
Testosterone has been widely investigated in associations with many aspects of social interactions, emotions and behavior. No research has been conducted on its contribution to the variability of love styles in human. The aim of this paper was to uncover the possible relationship between not only the actual plasma testosterone levels, but also the prenatal testosterone level (expressed as 2D:4D ratio) and the sensitivity of androgen receptor and love typology in young heathy men. There are six love styles which are primary including Eros (passionate romantic love), Ludus (playful) and Storge (friendly) and secondary love consisting of Mania (obsessive), Pragma (practical realistic) and Agape (altruistic)...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406696/proteomics-approach-for-identification-of-iga-nephropathy-related-biomarkers-in-urine
#12
P Prikryl, L Vojtova, D Maixnerova, M Vokurka, M Neprasova, T Zima, V Tesar
Proteinuria is often used as a surrogate marker in monitoring and predicting outcome in patients with chronic kidney diseases, but it is non-specific. IgAN belongs to the most common primary glomerulonephritis worldwide with serious prognosis. The main aim of this work was to assess differences in urine proteins in patients with IgA nephropathy and to identify abnormal proteins as potential biomarkers of IgA nephropathy or the renal disease. In our pilot project, we selected 20 patients and compared them with 20 healthy volunteers...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406695/visfatin-is-actively-secreted-in-vitro-from-u-937-macrophages-but-only-passively-released-from-3t3-l1-adipocytes-and-hepg2-hepatocytes
#13
P Svoboda, E KříŽová, K Čeňková, K Vápenková, J Zídková, V Zídek, V Škop
Visfatin is a multi-functional molecule that can act intracellularly and extracellularly as an adipokine, cytokine and enzyme. One of the main questions concerning visfatin is the mechanism of its secretion; whether, how and from which cells visfatin is released. The objective of this in vitro study was to observe the active secretion of visfatin from 3T3-L1 preadipocytes and adipocytes, HepG2 hepatocytes, U-937, THP-1 and HL-60 monocytes and macrophages. The amount of visfatin in media and cell lysate was always related to the intracellular enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), to exclude the passive release of visfatin...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406694/does-inhibition-of-aldose-reductase-contribute-to-the-anti-inflammatory-action-of-setipiprant
#14
J Ballekova, M Soltesova-Prnova, M Majekova, M Stefek
The aim of this study was to investigate aldose reductase inhibitory action of setipiprant as a potential additional mechanism contributing to its anti-inflammatory action. Aldose reductase activity was determined by spectrophotometric measuring of NADPH consumption. Setipiprant was found to inhibit aldose reductase/NADPH-mediated reduction of 4-hydroxynonenal, 4-hydroxynonenal glutathione and prostaglandin H2 substrates, all relevant to the process of inflammation. Molecular modeling simulations into the aldose reductase inhibitor binding site revealed an interaction pattern of setipiprant...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406693/polychlorinated-biphenyl-153-in-lipid-medium-modulates-differentiation-of-human-adipocytes
#15
D Mullerova, M Pesta, J Dvorakova, M Cedikova, V Kulda, P Dvorak, V Bouchalová, M Kralickova, V Babuska, J Kuncova, J Langmajerova, L Muller
Emerging evidence indicates that polychlorinated biphenyls (PCBs) are involved in the development of diabetes mellitus in the obese. The purpose of this study was to determine mechanisms by which PCB 153 (2,2´,4,4´,5,5´-hexachlorobiphenyl) could influence diet-induced obesity and insulin resistance during adipogenesis. Lineage of h-ADMSCs was differentiated either as control (differentiation medium only), or with lipid vehicle modelling high fat nutrition (NuTRIflex) or lipid free vehicle (dimethylsulfoxide) for 28 days with or without PCB 153 daily co-exposure (in three concentrations 0...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406692/effect-of-pre-and-post-weaning-high-fat-dietary-manipulation-on-intestinal-microflora-and-alkaline-phosphatase-activity-in-male-rats
#16
Z Šefčíková, D Bujňáková
We investigated the impact of a high-fat (HF) diet during pre- and post-weaning periods on the intestinal microbiota and alkaline phosphatase (AP) activity in male rats. Nutrition from birth was influenced by feeding rat dams with either a standard or HF diet. After weaning male pups nursed by control dams continued on a standard diet (CC) or HF diet (C->HF), while offspring nursed by HF dams continued on HF diet (HF) or standard diet (HF->C). The numbers of Bacteriodes/Prevotella (BAC) and Lactobacillus/Enterococcus (LAB) in the gut were determined by FISH technique...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28406691/lipopolysaccharide-induced-memory-impairment-in-rats-a-model-of-alzheimer-s-disease
#17
R Zakaria, W Mh Wan Yaacob, Z Othman, I Long, A H Ahmad, B Al-Rahbi
Alzheimer's disease (AD) is a primary cause of dementia in the middle-aged and elderly worldwide. Animal models for AD are widely used to study the disease mechanisms as well as to test potential therapeutic agents for disease modification. Among the non-genetically manipulated neuroinflammation models for AD, lipopolysaccharide (LPS)-induced animal model is commonly used. This review paper aims to discuss the possible factors that influence rats' response following LPS injection. Factors such as dose of LPS, route of administration, nature and duration of exposure as well as age and gender of animal used should be taken into account when designing a study using LPS-induced memory impairment as model for AD...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28248544/effect-of-exogenous-melatonin-treatment-on-the-reproductive-characteristics-and-progeny-of-male-rats-exposed-to-different-periods-from-light-and-darkness
#18
K Aa Majrashi, I Ah Barakat, A R Al-Himaidi, K Ag Adham
Light is an important environmental factor that controls the regulation of physiological functions of organisms. Melatonin is considered as one of the major hormones that play an important role in protecting body from many harmful effects and acts as a powerful anti-oxidant source to controlling the levels of antioxidant enzymes within the body. The main objectives of this work were to study the effect of 1) photoperiod changes and 2) exogenous melatonin hormone treatment on the sperm properties, body and testis weight, embryo characteristics, and concentration level of melatonin and testosterone in treated rat serum...
February 28, 2017: Physiological Research
https://www.readbyqxmd.com/read/28248543/biliary-system-architecture-experimental-models-and-visualization-techniques
#19
L Sarnova, M Gregor
The complex architecture of the liver biliary network represents a structural prerequisite for the formation and secretion of bile as well as excretion of toxic substances through bile ducts. Disorders of the biliary tract affect a significant portion of the worldwide population, often leading to cholestatic liver diseases. Cholestatic liver disease is a condition that results from an impairment of bile formation or bile flow to the gallbladder and duodenum. Cholestasis leads to dramatic changes in biliary tree architecture, worsening liver disease and systemic illness...
February 28, 2017: Physiological Research
https://www.readbyqxmd.com/read/28248542/two-photon-laser-scanning-microscopy-for-single-and-repetitive-imaging-of-dorsal-and-lateral-spinal-white-matter-in-vivo
#20
F Nadrigny, K Le Meur, H Steffens, E D Schomburg, S Safavi-Abbasi, P Dibaj
We developed appropriate surgical procedures for single and repetitive multi-photon imaging of spinal cord in vivo. By intravenous anesthesia, artificial ventilation and laminectomy, acute experiments were performed in the dorsal and lateral white matter. By volatile anesthesia and minimal-invasive surgery, chronic repetitive imaging up to 8 months were performed in the dorsal column through the window between two adjacent spines. Transgenic mouse technology enabled simultaneous imaging of labeled axons, astrocytes and microglia...
February 28, 2017: Physiological Research
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