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Physiological Research

M Táborský, D Richter, Z Tonar, T Kubíková, A Herman, J Peregrin, Z Husková, L Kopkan
This study evaluated the subacute morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation in sheep and also compared the efficiency of single-point and multiple-point ablation catheters. Effect of each ablation catheter approved for the clinical use (Symplicity Flex(TM), Medtronic, INC. or EnligHTN(TM), St. Jude Medical, INC.) was compared to intact contralateral renal artery in 12 sheep by histopathology and immunohistochemistry evaluation after a 10-day period post RDN procedure...
September 11, 2018: Physiological Research
Z Hirjaková, K Šuttová, J Kimijanová, D Bzdúšková, F Hlavačka
The study is aimed to examine balance control of slightly obese young adults during quiet stance and during gait initiation with and without crossing an obstacle. Forty-four young subjects were divided in two groups: control (BMI<25 kg/m(2)) and slightly obese (BMI from 25 to 35 kg/m(2)). Center of foot pressure (CoP) and kinematics of fifth lumbar vertebra (L5) were evaluated using a force plate and a motion capture system. During quiet stance with eyes open slightly obese group showed increased mean amplitude and velocity of CoP in anterior-posterior direction compared to normal weight subjects...
September 11, 2018: Physiological Research
Z Matloch, H Kratochvílová, A Cinkajzlová, M Lipš, P Kopecký, M Pořízka, D Haluzíková, J Lindner, M Mráz, J Kloučková, Z Lacinová, M Haluzík
Omentin is a protein produced by numerous tissues including adipose tissue. Its concentrations are decreased in patients with obesity, type 2 diabetes mellitus (DM) and coronary artery disease (CAD). Experimental studies suggest that omentin may have anti-inflammatory and insulin-sensitizing properties. In the present study, we measured circulating omentin levels and its mRNA expression in epicardial and subcutaneous fat, intercostal and heart muscle before and after elective cardiac surgery in patients with CAD (CAD+, DM-, n=18), combination of CAD and DM (CAD+, DM+, n=9) or with none of these conditions (CAD-, DM-, n=11)...
September 11, 2018: Physiological Research
P Přikryl, Z Hrušková, P Konopásek, Z Hladinová, V Tesař, M Vokurka
Hepcidin is a key regulator of iron metabolism and plays an important role in many pathologies. It is increased by iron administration and by inflammation, while erythropoiesis downregulates its expression. It decreases iron availability and thus contributes to anemia of chronic diseases. The aim of the study was to measure hepcidin as a marker and pathogenic factor in ANCA-associated vasculitis (AAV). Hepcidin plasma concentration was measured by the immunological method in 59 patients with AAV and compared to patients with non-vasculitic etiology of chronic kidney disease, patients on hemodialysis (HD), with systemic lupus erythematodes (SLE) and to healthy controls and blood donors, and was correlated with the parameters of iron metabolism, inflammation, activity of the process and kidney function...
September 11, 2018: Physiological Research
J Šilhavý, P Mlejnek, M Šimáková, I Vaněčková, M Behuliak, O Kuda, E Sticová, M Jirsa, M Pravenec
Telmisartan is an angiotensin receptor blocker (ARB) and a selective peroxisome proliferator activated receptor gamma (PPARG) modulator. Recently, we tested metabolic effects of telmisartan (5 mg/kg body weight) in spontaneously hypertensive rats (SHR) fed a diet containing 60% fructose, a widely used model of the metabolic syndrome. Surprisingly, we observed acute toxic effects of telmisartan. Rats lost body weight rapidly and died within 2 to 3 weeks due to bleeding into the upper gastrointestinal tract. SHR fed a high fructose diet and treated with telmisartan exhibited rapid decrease in blood pressure when compared to the SHR fed a high fructose diet and treated with valsartan...
September 11, 2018: Physiological Research
M Trávníčková, L Bačáková
Tissue engineering is a very promising field of regenerative medicine. Life expectancy has been increasing, and tissue replacement is increasingly needed in patients suffering from various degenerative disorders of the organs. The use of adult mesenchymal stem cells (e.g. from adipose tissue or from bone marrow) in tissue engineering seems to be a promising approach for tissue replacements. Clinical applications can make direct use of the large secretome of these cells, which can have a positive influence on other cells around...
September 11, 2018: Physiological Research
M Česká Burdová, M Kulich, D Dotřelová, G Mahelková
Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 patients with DM type 1 (DM1) and 20 healthy control subjects. The density of basal epithelial cells, keratocytes and endothelial cells, and the status of the subbasal nerve fibers were evaluated using in vivo corneal confocal microscopy...
September 11, 2018: Physiological Research
A Masopustová, P Jehlička, M Huml, T Votava, L Trefil, M Kreslová, J Sýkora
Acute lymphoblastic leukemia (ALL) and its treatment are associated with endothelial dysfunction (ED) and increased cardiovascular risk in adulthood. There are no data on ED in children after successful treatment of ALL. We aimed to assess new ED in these children using the plethysmographic Reactive Hyperemia Index (RHI) and biomarkers that are known to be related to ED. In all, 22 children (mean 15.6 yrs.), after successful treatment of ALL, and 18 healthy subjects were included in this prospective study. RHI, plasma concentrations of asymmetric dimethyl arginine (ADMA), high-sensitive CRP (hsCRP) and E-selectin were measured in all children...
September 11, 2018: Physiological Research
Yongmei Li, Wenna Zhang, Ruixiu Shi, Miao Sun, Lubo Zhang, Na Li, Zhice Xu
Prenatal exposure to caffeine can cause developmental problems. This study determined chronic influence of prenatal caffeine at relatively higher doses on cognitive functions in the rat offspring. Pregnant Sprague-Dawley rats (4-month-old) were exposed to caffeine (20 mg/kg, twice a day) for whole pregnancy from gestational day 4. Fetal and offspring body and brain weight was measured. Learning and memory were tested in adult offspring with Morris water maze; Learning and memory-related receptors were measured...
September 11, 2018: Physiological Research
P Čandik, D Rybár, F Depta, F Sabol, A Kolesár, K Galková, P Török, V Doničová, Š Imrecze, M Nosáľ, V Donič
Study of the relationship between ventilation parameters: monitored expiratory time constant - tau(edyn) and breathing - trigger frequency (f(trig)) and time of breathing cycle (T(cy)) are main goals of this article. Parameters were analyzed during last 4 hour +/- 2 before weaning from ventilation in 66 patients ventilated in pressure support mode (PSV). We have found out, that there exist mathematical relationships, observed during adequate gas exchange, yet not described. Monitored parameters are represented by: tau(edyn), f(trig) and T(cy)...
September 11, 2018: Physiological Research
J Lindovský, K Pysanenko, J Popelář, J Syka
We present a custom-made multielectrode array for the recording of evoked potentials during acute experiments in rats, which offers a quick and reliable estimation of the cortical tonotopy. The array consists of electrodes represented by insulated copper wires of 0.09 mm diameter fixed in epoxy resin in a 3 x 5 arrangement, with final impedances of 410 - 800 k Ohm. The array was placed on the brain surface of anaesthetized rats approximately at the location of the auditory cortex (AC) and the cortical evoked potentials (middle-latency responses, MLR) were elicited by a series of tone pips of different frequencies at 50 dB SPL intensity...
September 11, 2018: Physiological Research
P Makovický, M Chrenková, P Makovický, P Fľak, Z Formelová, V Novosadová, M Rajský, L Vannucci
The objective of this work was to compare the effect of selected feed mixtures on the duodenal morphology. One-hundred-four rats of the Wistar strain were divided to thirteen groups per eight rats. The experiment started at 35-days rats after birth and lasted for 32-days. The groups (A-M) were fed; commercial diet, 85% wheat and 15% oat diet, 85% wheat and 15% triticale, 85% wheat and 15% barley, 85% wheat and 15% amaranth, 85% wheat and 15% lantern, 85% wheat and 15% buckwheat, 100% wheat, 100% white lupine, 100% flock peas - variety Garden, 100% native peas - variety Garden, 100% native peas - variety Zekon or 100% extruded peas - variety Zekon diet respectively...
September 11, 2018: Physiological Research
A J Lopes, P S Vigário, A L Hora, C Al Deus, M S Soares, F S Guimaraes, A S Ferreira
Chronic obstructive pulmonary disease (COPD) is a progressive and disabling disease that has been associated with aging. Several factors may potentially impair performance during exercise in elderly patients with COPD. This study was conducted to evaluate what characteristics related to lung function, peripheral muscle strength and endurance can predict the performance of elderly patients with COPD during cardiopulmonary exercise testing (CPET). Forty elderly patients with COPD underwent resting lung function tests, knee isokinetic dynamometry, and CPET...
September 11, 2018: Physiological Research
M Gyurászová, A Kovalčíková, K Janšáková, K Šebeková, P Celec, Ľ Tóthová
Oxidative stress markers are usually measured in plasma, a stable environment for biomarkers. Blood collection is invasive, but the use of alternative biofluids is limited, due to high variability. In this study, we aimed to establish reference values for oxidative stress markers in plasma, urine and saliva of adult, healthy mice and to identify some sources of variability. Samples were obtained from 41 female and 37 male adult, healthy mice of the CD-1 strain, aged 95-480 days, weighing 21-55 grams. Reference ranges of TBARS (thiobarbituric acid reactive substances), AOPP (advanced oxidation protein products), fructosamine, GSH/GSSG (reduced and oxidised glutathione) ratio, TAC (total antioxidant capacity), and FRAP (ferric reducing antioxidant power) were measured in plasma and urine, and TBARS, GSH/GSSG ratio, TAC and FRAP in saliva, using standard spectrophotometric and fluorometric methods...
September 11, 2018: Physiological Research
G Grusova, L Lambert, T Grus, J Kavan, A Lambertova, A Burgetova, M Mlcek
The geometry of a distal anastomosis of a femoropopliteal bypass influences local hemodynamics and formation of intimal hyperplasia. We hypothesized that the distal anastomosis of an above-knee femoropopliteal bypass undergoes remodeling that results in displacement of the original course of the popliteal artery and change in the anastomosis angle. We identified 43 CT angiography examination with proximal femoropopliteal bypass and either a preserved contralateral popliteal artery or previous CTA before construction of the bypass for comparison...
September 11, 2018: Physiological Research
Hao-Hua Wang, Lin Min, Guang-da Xiang
High-mobility group box1(HMGB1) is newly discovered protein, which play a crucial role in the pathogenesis of systemic inflammation Recent studies showed that HMGB1 is one of the important pathophysiological mechanisms in the occurrence and development of atherosclerosis. The purpose of the present study was to investigate the relationship between serum HMGB1 levels and endothelial function in patients with polycystic ovary syndrome (PCOS). 80 newly diagnosed patients with PCOS and 80 normal women of similar age were selected...
September 11, 2018: Physiological Research
J Słomko, M Zawadka-Kunikowska, J J Klawe, M Tafil-Klawe, J Newton, P Zalewski
In this study we set out to understand is sleep fragmentation affects the cardiovascular regulation and circadian variability of core body temperature more or less than sleep deprivation. 50 healthy men (age 29.0+/-3.1 years; BMI 24.3+/-2.1 kg/m(2)) participated in a 3-day study that included one adaptative night and one experimental night involving randomization to: sleep deprivation (SD) and sleep fragmentation (SF). The evaluation included hemodynamic parameters, measures of the spectral analysis of heart rate and blood pressure variability, and the sensitivity of arterial baroreflex function...
September 11, 2018: Physiological Research
Z Riedelová, P Májek, K Pečánková, J Kučerová, F Surman, A De Los Santos Pereira, T Riedel
Early diagnosis of ongoing malignant disease is crucial to improve survival rate and life quality of the patients and requires sensitive detection of specific biomarkers e.g. prostate-specific antigen (PSA), carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), etc. In spite of current technological advances, malignant diseases are still identified in rather late stages, which have detrimental effect on the prognosis and treatment of the disease. Here, we present a biosensor able to detect fetuin-A, a potential multibiomarker...
October 30, 2018: Physiological Research
L Kotrchová, T Etrych
Novel star polymers based on the water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer and cyclodextrin were synthesized and the physico-chemical behavior of these precursors was studied. Semitelechelic HPMA copolymers were grafted onto the cyclodextrin core, thus forming star-like structure. Both prepared systems were designed as possible polymer carriers for the controlled release of cytostatic drugs, which after the drug release and degradation will be eliminated from the organism. Two synthesis approaches were used to obtain similar polymer carriers with different degradation rates...
October 30, 2018: Physiological Research
J Czernek, J Brus
The solid-state NMR measurements play an indispensable role in studies of interactions between biological membranes and peptaibols, which are amphipathic oligopeptides with a high abundance of alpha-aminobutyric acid (Aib). The solid-state NMR investigations are important in establishing the molecular models of the pore forming and antimicrobial properties of peptaibols, but rely on certain simplifications. Some of the underlying assumptions concern the parameters describing the 15N NMR chemical shielding tensor (CST) of the amide nitrogens in Aib and in conventional amino acids...
October 30, 2018: Physiological Research
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