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Endocrine Regulations

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https://www.readbyqxmd.com/read/27941180/sympathectomized-tumor-bearing-mice-survive-longer-but-develop-bigger-melanomas
#1
L Horvathova, A Tillinger, A Padova, B Mravec
OBJECTIVES: Previously we have shown that 20 days after the tumor cells injection smaller melanomas have been developed in chemically sympathectomized mice in comparison with animals having intact sympathetic nervous system. However, it is known that chemical sympathectomy reduces the sympathetic neurotransmission only temporarily. In the present study, we monitored the survival of the sympathectomized mice with melanoma with an attempt to find out how long the suppressing effect of sympathectomy on the melanoma growth may endure...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27941179/flaxseed-oil-supplementation-manipulates-correlations-between-serum-individual-mol-free-fatty-acid-levels-and-insulin-resistance-in-type-2-diabetics-insulin-resistance-and-percent-remaining-pancreatic-%C3%AE-cell-function-are-unaffected
#2
D E Barre, K A Mizier-Barre, O Griscti, K Hafez
OBJECTIVES: Elevated total serum free fatty acids (FFAs) concentrations have been suggested, controversially, to enhance insulin resistance and decrease percent remaining β-cell function. However, concentrations of individual serum FFAs have never been published in terms of their relationship (correlation) to homeostatic model assessment-insulin resistance (HOMA-IR) and percent remaining β-cell function (HOMA-%β) in the type 2 diabetics (T2Ds). Alpha-linolenic acid consumption has a negative correlation with the insulin resistance, which in turn is negatively correlated with the remaining β-cell function...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27941178/alternative-renin-angiotensin-system-pathways-in-adipose-tissue-and-their-role-in-the-pathogenesis-of-obesity
#3
M Slamkova, S Zorad, K Krskova
Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner. The classical RAS has been found to be over-activated during the adipose tissue enlargement, thus elevated generation of angiotensin II (Ang II) may contribute to the obesity pathogenesis. The contemporary view on the RAS has become more complex with the discovery of alternative pathways, including angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor, (pro)renin receptor, as well as angiotensin IV(Ang IV)/AT4 receptor...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27941177/effect-of-the-autonomic-nervous-system-on-cancer-progression-depends-on-the-type-of-tumor-solid-are-more-affected-then-ascitic-tumors
#4
L Horvathova, B Mravec
OBJECTIVES: A number of recently published studies have shown that the sympathetic nervous system may influence cancer progression. There are, however, some ambiguities about the role of the parasympathetic nerves in the modulation of growth of different tumor types. Moreover, tumor models used for investigation of the autonomic neurotransmission role in the processes related to the cancer growth and progression are mainly of the solid nature. The knowledge about the nervous system involvement in the modulation of the development and progression of malignant ascites is only fragmental...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27941176/protective-effects-of-boron-and-vitamin-e-on-ethylene-glycol-induced-renal-crystal-calcium-deposition-in-rat
#5
H Bahadoran, M R Naghii, M Mofid, M H Asadi, K Ahmadi, A Sarveazad
OBJECTIVES: Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation. METHODS: Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75% ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the first day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group)...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27941175/a-case-of-hypercalcaemic-crisis-secondary-to-coexistence-of-primary-hyperparathyroidism-and-graves-disease
#6
S Baldane, S H Ipekci, R Evcen, G K Gedik, I Guler, L Kebapcilar
A 46 year-old female patient presented to the hospital with ongoing and progressively increasing fatigue, severe nausea and vomiting, loss of appetite, constipation, palpitations and somnolence. Laboratory evaluation revealed a severe hypercalcaemia and overt hyperthyroidism. She was diagnosed with primary hyperparathyroidism accompanied by Graves' disease. The patient underwent total thyroidectomy and right inferior parathyroid gland adenoma excision on the 24th day of her admission to the hospital after calcium levels and free thyroid hormone levels were brought to normal ranges...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560800/multiple-functions-and-essential-roles-of-nuclear-receptor-coactivators-of-bhlh-pas-family
#7
REVIEW
L Pecenova, Robert Farkas
Classical non-peptide hormones, such as steroids, retinoids, thyroid hormones, vitamin D3 and their derivatives including prostaglandins, benzoates, oxysterols, and bile acids, are collectively designated as small lipophilic ligands, acting via binding to the nuclear receptors (NRs). The NRs form a large superfamily of transcription factors that participate virtually in every key biological process. They control various aspects of animal development, fertility, gametogenesis, and numerous metabolic pathways, and can be misregulated in many types of cancers...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560799/the-role-of-retinoic-acid-receptors-and-their-cognate-ligands-in-reproduction-in-a-context-of-triorganotin-based-endocrine-disrupting-chemicals
#8
REVIEW
Dana Macejova, L Toporova, J Brtko
Retinoic acid (RA), an active form of vitamin A, regulates the embryonic development, male and female reproduction and induces important effects on the cell development, proliferation, and differentiation. These effects are mediated by the retinoid (RAR) and rexinoid nuclear receptors (RXR), which are considered to be a ligand-activated, DNA-binding, trans-acting, and transcription-modulating proteins, involved in a general molecular mechanism responsible for the transcriptional responses in target genes. Organotin compounds are typical environmental contaminants and suspected endocrine disrupting substances...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560798/elevated-neutrophil-lymphocyte-ratio-in-patients-with-euthyroid-chronic-autoimmune-thyreotidis
#9
Havva Keskin, Y Kaya, K Cadirci, C Kucur, E Ziypak, E Simsek, H Gozcu, S Arikan, A Carlioglu
OBJECTIVE: The neutrophil-lymphocyte ratio (NLR), determined from peripheral blood, is accepted as an available and practical indicator of the systemic inflammation. In this study, we aimed to determine whether the NLR was higher in euthyroid chronic autoimmune thyreotidis (CAT) patients compared to a healthy control group. METHODS: A total of 112 patients were enrolled in this study, including 59 patients with euthyroid CAT on any form of therapy and 53 healthy controls...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560797/an-unusual-case-in-endocrinology-practice-suture-granuloma
#10
Guven Baris Cansu, B Bakar, T Bakar, B P Cengiz
OBJECTIVE: Suture granuloma, the rare complication of thyroidectomy, results from the use of nonabsorbable suture materials. Despite its typical ultrasound images and benign course, it carries utmost importance in the diff erential diagnosis of lymph nodes, recurrent nodules, and recurrence in the case of thyroid cancers. Subject and Results. Fifty four years old female patient, who underwent bilateral thyroidectomy in July 2010, was diagnosed with multinodular goiter and incidentally discovered micropapillary carcinoma (2 mm)...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560796/continuous-cold-exposure-induces-an-anti-inflammatory-response-in-mesenteric-adipose-tissue-associated-with-catecholamine-production-and-thermogenin-expression-in-rats
#11
P Vargovic, G Manz, R Kvetnansky
OBJECTIVE: Continuous exposure to cold leads to an activation of adaptive thermogenesis in the brown adipose tissue and induction of brown/beige cell phenotype in the white adipose tissue. Thermogenic response is associated with alternatively activated macrophages producing catecholamines, which subsequently activate the uncoupling protein 1 (UCP-1). The aim of this work was to elucidate the effect of cold exposure on catecholamine and immune responses associated with adipocyte browning in the mesenteric adipose tissue (mWAT) of rat...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560795/inhibition-of-ire1-signaling-affects-the-expression-of-genes-encoded-glucocorticoid-receptor-and-some-related-factors-and-their-hypoxic-regulation-in-u87-glioma-cells
#12
D O Minchenko, O O Riabovol, D O Tsymbal, O O Ratushna, O H Minchenko
OBJECTIVE: The aim of the present investigation was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of genes encoding glucocorticoid receptor (NR3C1) and some related proteins (SGK1, SGK3, NCOA1, NCOA2, ARHGAP35, NNT) and their hypoxic regulation in U87 glioma cells for evaluation of their possible significance in the control of the glioma growth...
July 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560641/micro-rnas-an-arguable-appraisal-in-medicine
#13
REVIEW
K Voglova, J Bezakova, Iveta Herichova
Micro RNAs (miRNAs) represent a newly discovered class of regulatory molecules in the human body. miRNA is a short double stranded RNA sequence interfering with mRNA, causing in most cases, inhibition of translation. Synthesis of miRNAs shows an increasing developmental pattern and postnatally miRNAs are synthesized in all cells possessing transcriptional machinery. miRNAs usually target several mRNAs and therefore conclusive evidences proving their functions are not always ease to be acquired. In spite of this difficulty, functions of miRNAs were firmly established in the development, the cardiovascular and neural diseases, and cancer...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560640/progress-in-micro-rna-focused-research-in-endocrinology
#14
REVIEW
K Voglova, J Bezakova, Iveta Herichova
Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists' interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its expression. It has been estimated that 30% of human gene expression is regulated by miRNAs. One miRNA usually targets several mRNAs and one mRNA can be regulated by several miRNAs. miRNA biogenesis is realized by key enzymes, Drosha and Dicer. miRNA/mRNA interaction depends on binding to RNA-induced silencing complex...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560639/mechanisms-involved-in-the-regulation-of-neuropeptide-mediated-neurite-outgrowth-a-minireview
#15
REVIEW
Z Lestanova, Z Bacova, Jan Bakos
The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides. However, regardless of the differences in the local responses elicited by neuropeptides, there exist certain functional similarities in the effects of neuropeptides, mediated by their receptors. In the present review, data of the relevant studies, focused on G protein-coupled receptors activated by neuropeptides, are summarized...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560638/gestational-diabetes-an-overview-with-attention-for-developing-countries
#16
REVIEW
M Schiavone, G Putoto, F Laterza, Damiano Pizzol
Gestational diabetes mellitus (GDM) is defined as a glucose intolerance that occurs for the first time or it is first identified during pregnancy. The GDM etiology is multifactorial. It has not completely been established yet and several known risk factors may contribute to its onset. To date, there are no shared guidelines on the management and follow-up, especially regarding the low-income countries. In this paper, we describe the state of art about epidemiology, physiopathology, diagnosis, and management of GDM...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560637/role-of-interlekin-35-as-a-biomarker-in-patients-with-newly-diagnosed-hashimoto-s-thyroiditis
#17
Hakki Yilmaz, M Cakmak, B Ceydilek, C Demir, A Aktas
OBJECTIVE: Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto's thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560636/effect-of-hypoxia-on-the-expression-of-genes-encoding-insulin-like-growth-factors-and-some-related-proteins-in-u87-glioma-cells-without-ire1-function
#18
Dmytro O Minchenko, A P Kharkova, O V Halkin, L L Karbovskyi, O H Minchenko
OBJECTIVE: The aim of the present study was to investigate the effect of hypoxia on the expression of genes encoding insulin-like growth factors (IGF1 and IGF2), their receptor (IGF1R), binding protein-4 (IGFBP4), and stanniocalcin 2 (STC2) in U87 glioma cells in relation to inhibition of endoplasmic reticulum stress signaling mediated by IRE1 (inositol requiring enzyme 1) for evaluation of their possible significance in the control of tumor growth. METHODS: The expression of IGF1, IGF2, IGF1R, IGFBP4, and STC2 genes in U87 glioma cells transfected by empty vector pcDNA3...
April 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560635/comparison-of-clinical-and-biochemical-variables-in-type-2-diabetes-mellitus-patients-and-their-first-degree-relatives-with-metabolic-syndrome-in-benin-city-nigeria-a-cross-sectional-case-controlled-study
#19
COMPARATIVE STUDY
S Ogedengbe, I U Ezeani, E Aihanuwa
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is characterized by a relative insulin deficiency or insulin resistance. It is also associated with a cluster of metabolic abnormalities, including hyper-tension and dyslipidemia. Although there are many studies that have studied the metabolic abnormalities in T2DM patients with metabolic syndrome (MetS), only few of them have assessed the metabolic abnormalities in their first-degree relatives (FDRs) who had MetS. The aim of this study is to compare the clinical and biochemical variables in T2DM subjects and their FDRs without diabetes in Benin City, Nigeria...
January 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27560634/pancrelipase-treatment-in-a-patient-with-the-history-of-roux-en-y-gastric-bypass-operation-that-developed-resistant-hypocalcemia-secondary-to-total-thyroidectomy
#20
S Baldane, S H Ipekci, L Kebapcilar
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) is an independent risk factor for moderate hypocalcaemia and may lead to the development of resistant hypocalcaemia following thyroid surgery. Subject and Results. A 35-year old female patient was referred to our hospital by her family physician for treatment of resistant hypocalcaemia. The patient underwent RYGB three years ago and a total thyroidectomy for a benign thyroid nodule one year ago. Calcitriol, calcium carbonate, magnesium oxide, and ergocalciferol therapeutic dosages were incremented...
January 2016: Endocrine Regulations
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