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International Journal of Antimicrobial Agents

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https://www.readbyqxmd.com/read/28923459/complete-sequence-of-pbm413-a-novel-multi-drug-resistance-megaplasmid-carrying-qnrvc6-and-blaimp-45-from-pseudomonas-aeruginosa
#1
Junyan Liu, Ling Yang, Dingqiang Chen, Brian M Peters, Lin Li, Bing Li, Zhenbo Xu, Mark E Shirtliff
This study aimed to characterize a novel multi-drug-resistance megaplasmid carrying qnrVC6 and blaIMP-45 from Pseudomonas aeruginosa strain Guangzhou-Pae617 isolated from a hospital in Guangzhou, China in 2012. The plasmid pBM413 has a length of 423,017 bp and an average G+C content of 56.41%. A qnrVC6 gene flanked by two copies of ISCR1 elements, a multiresistance class 1 integron In786 containing aacA4→blaIMP-45→blaOXA-1→catB3 cassettes, an armA gene and an aphA7 gene flanked by two copies of IS26 elements were identified...
September 15, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28919197/imported-poultry-meat-as-a-source-of-extended-spectrum-cephalosporin-resistant-cmy-2-producing-salmonella-heidelberg-and-s-minnesota-in-european-union-2014-2015
#2
Joana Campos, Joana Mourão, Leonor Silveira, Margarida Saraiva, Cristina Belo Correia, Ana Paula Maçãs, Luísa Peixe, Patrícia Antunes
Extended-spectrum cephalosporin (ESC)-resistant Salmonella has been described at low level in EU, nevertheless the increasing importation of poultry meat could be an important source of epidemic strains carrying ESC-resistant genes. We evaluated ESC resistance and characterized genetic platforms as well as the clonal relatedness of Salmonella isolates from poultry meat products imported into Portugal. All Salmonella isolates recovered from samples of fresh meat destined to be imported into the EU in the scope of Portuguese official border control between 2014 and 2015 were studied...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28919196/inca-c-plasmids-conferring-high-azithromycin-resistance-in-vibrio-cholera
#3
Ruibai Wang, Haican Liu, Xiuqin Zhao, Jie Li, Kanglin Wan
Azithromycin (AZM) is a clinically important antibiotic to Vibrio cholerae especially for inhibiting colonization of V. cholerae in intestine and the treatment of severe cholera in children and pregnant women. One IncA/C plasmid was isolated from both of the high MIC AZM resistant V cholerae strains of the two mainly pathogenic serogroups, O1 and O139. In the 172 predicted ORFs, 16 genes were related to antibiotic resistance in which 5 were well-defined genes associated with macrolide resistance. The 5 macrolide resistant genes disturbed in two clusters, mphR-mrx-mph(K) and mel-mph2, flanking by insertion sequence (IS) and involving two kinds of mechanisms...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28919195/combination-versus-monotherapy-for-gram-negative-bloodstream-infections-matching-by-predicted-prognosis
#4
Julie Ann Justo, P Brandon Bookstaver, Joseph Kohn, Helmut Albrecht, Majdi N Al-Hasan
The utility of empirical combination antimicrobial therapy for gram-negative bloodstream infections (BSI) remains unclear. This retrospective, quasi-experimental matched cohort study examined the impact of empirical combination therapy on mortality in patients with gram-negative BSI. Hospitalized adults with gram-negative BSI from 1 January 2010 to 31 December 2013 at Palmetto Health Hospitals in Columbia, SC, USA were identified. Patients receiving combination or beta-lactam monotherapy therapy were matched 1:1 based on age, sex and Bloodstream Infection Mortality Risk Score (BSIMRS)...
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28919194/discovery-and-characterization-of-an-escherichia-coli-st206-strain-producing-ndm-5-and-mcr-1-from-a-patient-with-acute-diarrhea
#5
LETTER
Beiwen Zheng, Tao Lv, Hao Xu, Xiao Yu, Yunbo Chen, Jiahua Li, Chen Huang, Lihua Guo, Jing Zhang, Xiawei Jiang, Yonghong Xiao, Lanjuan Li
No abstract text is available yet for this article.
September 14, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28890395/the-antifungal-arsenal-alternative-drugs-and-future-targets
#6
Nathan P Wiederhold
Clinically available antifungals for the treatment of invasive fungal infections primarily target either ergosterol in the fungal cell membrane or 1,3-β-D-glucan in the fungal cell wall. These classes include the polyene amphotericin B, the triazoles, and the echinocandins. Although newer antifungals and improved formulations of others have advanced our ability to treat patients with invasive mycoses, these drugs are often limited by toxicities, drug interactions, and the need for intravenous administration...
September 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28890394/on-the-antiviral-activity-and-developmental-toxicity-of-6-methylmercaptopurine-riboside-6mmpr
#7
LETTER
Francisco José Roma Paumgartten
No abstract text is available yet for this article.
September 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28890393/the-antiviral-activity-of-arbidol-hydrochloride-against-herpes-simplex-virus-type-i-in-vitro-and-in-vivo
#8
Min-Ke Li, Yuan-Yuan Liu, Fei Wei, Meng-Xin Shen, Yan Zhong, Shan Li, Liang-Jun Chen, Nian Ma, Bing-Yu Liu, Yi-Dong Mao, Ning Li, Wei Hou, Hai-Rong Xiong, Zhan-Qiu Yang
Herpes simplex virus type 1 (HSV-1) causes significant human diseases from skin lesions to encephalitis, especially in neonates and immunocompromised hosts. The discovery of novel anti-HSV-1 drugs with low toxicity is in demand for public health. Arbidol Hydrochloride (ARB) is an indole-derivative molecule with broad-spectrum antiviral activity. In this study, we evaluated the antiviral effects of ARB against HSV-1 infection using in vitro and in vivo models. The results showed that ARB presents significant inhibitory effect on HSV-1 plaque formation and generation of progeny virus with EC50 value of 5...
September 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887203/clinical-relevance-of-metronidazole-and-peripheral-neuropathy-a-systematic-review-of-the-literature
#9
REVIEW
Tiffany A Goolsby, Bernadette Jakeman, Robert P Gaynes
The objective of this paper was to review and evaluate the literature on metronidazole-associated peripheral neuropathy and determine the relevance in clinical practice. MEDLINE/PubMed, EBSCO, and Google Scholar were searched through February 2017 using the search terms metronidazole and peripheral neuropathy, or polyneuropathy, or paresthesia, or neurotoxicity. Relevant case reports, retrospective studies, surveys, and review articles were included. Bibliographies of all relevant articles were reviewed for additional sources...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887202/hospital-sewage-water-a-reservoir-for-variants-of-new-delhi-metallo-%C3%AE-lactamase-blandm-and-esbl-producing-enterobacteriaceae
#10
Shadab Parvez, Asad U Khan
New Delhi metallo-β-lactamase (NDM)-producing Enterobacteriaceae has become a threat to public health. Hospital sewage is generally unexplored, having a potential for harbouring bacteria causing healthcare-associated infections. Hence, we initiated this study to monitor NDM-producing Enterobacteriaceae in hospital sewage water. We detected 32 isolates with blaNDM variants, 17 Escherichia coli, 8 Citrobacter freundii, 4 Shigella boydii, 2 Citrobacter braakii, and 1 Citrobacter farmeri in hospital sewage water, showing resistance to all antibiotics except colistin...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887201/reactive-oxygen-therapy-a-novel-antimicrobial
#11
REVIEW
Matthew Dryden
The main solution to the global antibiotic resistance crisis is reducing the volume of antibiotic use in medicine, agriculture and the environment. However there is also a pressing need for novel antimicrobials. Despite much rhetoric, there are few entirely novel agents in development. One such therapy to reach clinical use is an agent using Reactive Oxygen Species (ROS), oxygen radicals, as an antimicrobial mechanism. ROS can be delivered to the site of infection in various formats. ROS is highly antimicrobial against Gram positive and negative bacteria, viruses and fungi...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887200/purification-and-characterization-of-a-novel-anti-staphylococcal-peptide-asp-1-from-bacillus-sp-urid-12-1
#12
Ajay Ghosh Chalasani, Utpal Roy, Sushma Nema
A strong anti-methicillin resistant Staphylococcus aureus (MRSA) peptide (ASP-1) from the Bacillus subtilis URID 12.1 strain that is active against cefoxitin- and methicillin-resistant clinical isolates was purified to homogeneity by solvent extraction, silica gel-based adsorption chromatography and reversed phase High Performance Liquid Chromatography. The peptide sequence of ASP-1 as determined by MALDI-TOF/MS and ESI-FTICR MS was acetylated Phe-Thr-Ala-Val-Dhb-Phe-Ile/Leu. The peptide was further analyzed by alkaline hydrolysis, ESI-Q-TOF-MS and an ion mobility assay, which detected the presence of a lactone ring in the intact peptide and a cyclic nature, subsequently revealing the peptide sequence as acPhe-Thr-Val-Ala-Dhb-Phe-Ile/Leu...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28887199/temporal-evolution-of-polymyxin-b-resistant-klebsiella-pneumoniae-clones-recovered-from-blood-cultures-in-a-teaching-hospital-during-a-7-year-period
#13
Graziela Braun, Rodrigo Cayô, Adriana Pereira Matos, Juliane de Mello Fonseca, Ana Cristina Gales
The polymyxins have become one of the last resorts to treat serious infections caused by KPC-2-producing Klebsiella pneumoniae worldwide. However, the increase of polymyxin consumption has favored the emergence of resistance to these compounds. In this study we observed an increase in the polymyxin B resistance rates from 0 to 30.6% among 224 K. pneumoniae isolates recovered from blood cultures between 2009 and 2015. Only gentamicin, tigecycline and fosfomycin remained active against the polymyxin B-resistant K...
September 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28847696/neurological-adverse-events-associated-with-metronidazole
#14
LETTER
Michael S Gelfand, Kerry O Cleveland
No abstract text is available yet for this article.
August 25, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843823/inhibitory-and-bactericidal-effect-of-artilysin-%C3%A2-art-175-against-colistin-resistant-mcr-1-positive-escherichia-coli-isolates
#15
LETTER
Eva Schirmeier, Pia Zimmermann, Veronika Hofmann, Manfred Biebl, Hans Gerstmans, Veerle Et Maervoet, Yves Briers
No abstract text is available yet for this article.
August 23, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843822/clofazimine-protects-against-mycobacterium-tuberculosis-dissemination-in-the-cns-following-an-aerosol-challenge-in-a-murine-model
#16
Sooraj Baijnath, Chivonne Moodley, Bongani Ngcobo, Sanil D Singh, Hendrik G Kruger, Per I Arvidsson, Tricia Naicker, Alexander Pym, Thavendran Govender
BACKGROUND: Tuberculosis (TB) has been the scourge of the human race for many decades, claiming countless number of lives along the way. This is further complicated by the ability of Mycobacterium tuberculosis (M.tb) to infect extra-pulmonary sites, more specifically the brain. These forms of TB are difficult to treat due to the problems associated with drug delivery across the blood brain barrier (BBB). Linezolid (LZD and clofazimine (CFZ) are two of the more promising anti-TB antibiotics in recent times...
August 23, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843821/activity-of-2-quinolin-4-yloxy-acetamides-in-mycobacterium-tuberculosis-clinical-isolates-and-identification-of-their-molecular-target-by-whole-genome-sequencing
#17
Fernanda Teixeira Subtil, Anne Drumond Villela, Bruno Lopes Abbadi, Valnês S Rodrigues-Junior, Cristiano Valim Bizarro, Luis Fernando Saraiva Macedo Timmers, Osmar Norberto de Souza, Kenia Pissinate, Pablo Machado, Alexandre López-Gavín, Griselda Tudó, Julian González-Martín, Luiz Augusto Basso, Diógenes Santiago Santos
The 2-(quinolin-4-yloxy)acetamides (QOAs) have been reported as promising molecules for tuberculosis treatment. Recent studies demonstrated its potent antimycobacterial activity, as well as its biological stability and synergism with rifampicin. The identification of the molecular target is an essential step towards the development of a novel drug candidate. Here we report the target identification of the QOAs. We found that these compounds are active against isoniazid, rifampicin, ethambutol, streptomycin and ethionamide resistant clinical isolates from M...
August 23, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843820/multiple-paths-towards-reduced-membrane-potential-and-concomitant-reduction-in-aminoglycoside-susceptibility-in-staphylococcus-aureus
#18
Martin Vestergaard, Katrine Nøhr-Meldgaard, Hanne Ingmer
Staphylococcus aureus confers life-threatening and difficult to treat infections worldwide and antimicrobial resistance is an increasing concern. While acquired resistance has been widely studied, little is known of the contributions from chromosomal determinants that upon inactivation may reduce the susceptibility towards antibiotics. The aim of this study was to identify genetic determinants that upon inactivation reduce aminoglycoside susceptibility in Staphylococcus aureus. We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S...
August 23, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843819/eradication-of-mrsa-throat-carriage-a-randomized-trial-comparing-topical-treatment-with-rifampicin-based-systemic-therapy
#19
Anna-Karin Lindgren, Anna C Nilsson, Per Åkesson, Eva Gustafsson, Eva Melander
OBJECTIVES: Eradication of MRSA colonization may prevent transmission of strains between patients and reduces the risk of clinical infection. Colonization of the throat is associated with prolonged carriage and is more difficult to eradicate. METHODS: An open randomized study was conducted to evaluate two eradication protocols. Patients with pharyngeal carriage of MRSA were enrolled at six Swedish centers during four years. One treatment group received oral rifampicin and clindamycin or trimethoprim-sulfamethoxazole for seven days, in combination with nasal mupirocin...
August 23, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28843818/perillyl-alcohol-exhibits-in-vitro-inhibitory-activity-against-plasmodium-falciparum-and-protects-against-experimental-cerebral-malaria
#20
Adriana A Marin Rodriguez, Leonardo J M Carvalho, Emilia A Kimura, Alejandro M Katzin
The development of new drugs is one of the strategies to control malaria. Isoprenoid biosynthesis in Plasmodium falciparum is an essential pathway for parasite survival, and therefore a potential target for new antimalarial drugs. Indeed, plant-derived secondary metabolites such as terpenes exhibit antimalarial activity in vitro by inhibiting isoprenoid biosynthesis in P. falciparum. In this study, the in vitro antiplasmodial activity of perillyl alcohol (POH) was evaluated, along with its in vitro toxicity and its effect on the isoprenylation process...
August 23, 2017: International Journal of Antimicrobial Agents
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