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International Journal of Antimicrobial Agents

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https://www.readbyqxmd.com/read/28729124/trends-in-antimicrobial-resistance-in-neisseria-gonorrhoeae-and-molecular-characteristics-of-neisseria-gonorrhoeae-with-decreased-susceptibility-to-ceftriaxone-in-shandong-china-2007-to-2014
#1
Lihong Zhao, Aihua Liu, Ruiying Li, Shuping Zhao
In this study, the trends of AMR in N. gonorrhoeae were analyzed in Shandong Province of China during 2007-2014. Moreover, the ceftriaxone genetic resistance determinants including penA, mtrR, penB, ponA, and pilQ genes were sequenced, and the molecular mechanisms of decreased susceptibility or resistance to ceftriaxone in N. gonorrhoeae were elucidated. Overall, the increasing trends of resistance to PEN, TET, and CIP, and decreasing trends of susceptibility to CRO and AZM were observed in Shandong Province of China between 2007 and 2014...
July 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28729123/increased-colistin-resistance-upon-acquisition-of-plasmid-mediated-mcr-1-gene-in-escherichia-coli-isolates-with-chromosomally-encoded-reduced-susceptibility-to-polymyxins
#2
LETTER
Aurélie Jayol, Patrice Nordmann, Catherine André, Véronique Dubois, Laurent Poirel
No abstract text is available yet for this article.
July 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28711678/linezolid-in-liver-failure-exploring-the-value-of-the-maximal-liver-function-capacity-limax-test-in-a-pharmacokinetic-pilot-study
#3
Sebastian G Wicha, Otto R Frey, Anka C Roehr, Johann Pratschke, Martin Stockmann, Rawan Alraish, Tilo Wuensch, Magnus Kaffarnik
BACKGROUND: Patients in the intensive care unit frequently require antibiotic treatment. Liver impairment possesses substantial challenges for dose selection in these patients. The aim of the present pilot study was to assess the novel maximal liver function capacity (LiMAx test) in comparison to conventional liver function markers as covariates of drug clearance in liver failure using linezolid as model drug. METHODS: 28 patients with different degrees of liver failure were recruited and LiMAx test, plasma, dialysis and urine sampling was performed under linezolid steady-state therapy (600 mg BID)...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28711677/extended-spectrum-of-antibiotic-susceptibility-for-tuberculosis-djibouti
#4
Fériel Bouzid, Hélène Astier, Djaltou Aboubaker Osman, Emilie Javelle, Mohamed Osman Hassan, Fabrice Simon, Eric Garnotel, Michel Drancourt
The Horn of Africa suffers from a high prevalence of tuberculosis which is reported to be partly driven by multi-drug resistant (MDR) Mycobacterium tuberculosis strictu sensu strains. We conducted a prospective study to investigate M. tuberculosis complex species causing tuberculosis in Djibouti; along with their in vitro susceptibility to standard anti-tuberculous antibiotics, in addition to clofazimine, minocycline, chloramphenicol and sulfadiazine. Among the 118 mycobacteria isolates from 118 successive patients with suspected pulmonary tuberculosis, 111 strains of M...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28711676/should-we-consider-fecal-colonization-with-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-empiric-therapy-of-community-onset-sepsis
#5
Daša Stupica, Lara Lusa, Mirijam Nahtigal Klevišar, Sara Terzić, Mateja Pirš, Manica Mueller Premru, Franc Strle
In patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), the preference for carbapenems (CRB) over non-CRB antibiotics for empiric therapy of sepsis is questionable from an ecologic perspective and also how well colonization actually predicts an ESBL-E etiology of infection has been poorly investigated. The purpose of this retrospective observational study was to determine the positive predictive value (PPV) of ESBL-E fecal colonization for ESBL-E etiology of sepsis and the impact of empiric therapy on treatment outcome...
July 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28709990/in-vitro-development-of-an-effective-treatment-for-acanthamoeba-keratitis
#6
A Ortillés, J Belloc, E Rubio, M T Fernández, M Benito, J A Cristóbal, B Calvo, P Goñi
The aim of this study was to develop an in-vitro topical treatment for acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Riboflavin with ultraviolet-A (R+UV-A) as monotherapy or combined with voriconazole and moxifloxacin was also tested. Quantitative assays to assess cyst viability after treatment were performed for the chemicals that showed the highest activity in the qualitative assays...
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28709989/evaluating-biapenem-dosage-regimens-in-intensive-care-unit-patients-with-pseudomonas-aeruginosa-infections-a-pharmacokinetic-pharmacodynamic-analysis-using-monte-carlo-simulation
#7
Yongfu Hang, Yafang Chen, Ling Xue, Shusen Sun, Long Liu, Jie Gao, Cheng Xie, Xianfeng Zhang, Jianguo Zhu, Jun Jin, Liyan Miao
This study sought to both identify optimal dosage regimens and estimate pharmacokinetic/pharmacodynamics characteristics of short-infusion (SI) versus extended-infusion (EI) for the use of biapenem against Pseudomonas aeruginosa infections in Chinese Intensive Care patients. A total of 85 strains of P. aeruginosa were collected, and the minimum inhibitory concentration (MIC) of biapenem was measured by the serial two-fold agar dilution method. We designed four frequently used clinical regimens: biapenem 300mg I...
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28709988/genetic-characterization-confirms-sporadic-occurrence-of-vancomycin-resistant-enterococcus-faecalis-in-copenhagen-denmark
#8
LETTER
Barbara J Holzknecht, Mette Pinholt, Heidi Gumpert, Anette M Hammerum, Henrik Westh
No abstract text is available yet for this article.
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705678/pharmacodynamics-of-minocycline-against-acinetobacter-baumannii-studied-in-a-pharmacokinetic-model-of-infection
#9
Wadha A Alfouzan, A R Noel, Karen E Bowker, Mlg Attwood, S G Tomaselli, Alasdair P MacGowan
OBJECTIVES: Minocycline (MIN) is an old antibiotic which may have an important role in the treatment of multidrug Gram-negative infection as the burden of such infectious increase. METHODS: We used a single compartment dilutional pharmacokinetic model to determine the relationship between MIN exposure and antibacterial effect, including risk of emergence of resistance against strains of Acinetobacter baumannii. RESULTS: The unbound drug area-under-the-curve to MIC ratio (fAUC/MIC) associated with a 24h bacteriostatic effect was 16...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705677/hyicin-4244-the-first-sactibiotic-described-in-staphylococci-exhibits-an-anti-staphylococcal-biofilm-activity
#10
Andreza Freitas de Souza Duarte, Hilana Ceotto-Vigoder, Emile Santos Barrias, Thaïs Cristina Baeta Soares Souto-Padrón, Ingolf Figved Nes, Maria do Carmo de Freire Bastos
Hyicin 4244 is a small antimicrobial peptide with a broad-spectrum of activity found in the culture supernatant of Staphylococcus hyicus 4244, whose genome was then sequenced. The bacteriocin gene cluster (hyiSABCDEFG) was mined from its single chromosome and exhibited a genetic organization similar to that of subtilosin A. All genes involved in hyicin 4244 biosynthesis proved to be transcribed and encode proteins that share at least 42 % similarity to proteins encoded by the subtilosin A gene cluster. Due to its resemblance to subtilosin A and the presence of three thioether bonds in its structure, hyicin 4244 is assumed to be a 35 amino acid circular sactibiotic, the first to be described in staphylococci...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705676/current-antifungal-treatment-of-fusariosis
#11
Abdullah M S Al-Hatmi, Alexandro Bonifaz, Stephane Ranque, G Sybren de Hoog, Paul E Verweij, Jacques F Meis
Fungi of the genus Fusarium are well known as major plant pathogens and soil inhabitants but also cause a broad spectrum of human infections. Fusariosis is the second most common mould infection after aspergillosis and keratitis is the most encountered implantation infection in immunocompetent individuals. Natamycin is active against Fusarium species both in vitro and in vivo, and it is used along with voriconazole as the mainstay of treatment for Fusarium keratitis. Onychomycosis is treated with terbinafine, voriconazole and sometimes itraconazole...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705675/use-of-evidence-based-recommendations-in-an-antibiotic-care-bundle-for-the-intensive-care-unit
#12
Nico T Mutters, Giulia De Angelis, Giovanni Restuccia, Francesca Di Muzio, Jeroen Schouten, Marlies Hulscher, Massimo Antonelli, Evelina Tacconelli
PURPOSE: To drive decisions on antibiotic therapy in the intensive care unit (ICU), we developed an antibiotic care bundle (ABC-Bundle) with evidence-based recommendations (EBRs) for antibiotic prescriptions. METHODS: We conducted a 3-step prospective study. First, a systematic review of the literature reporting EBRs for antibiotic usage in the ICU was performed. Second, we developed an ABC-Bundle through a 2-round, RAND-modified Delphi method with an international expert panel, including the most relevant EBRs on a 9-point Likert scale...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705674/molecular-bases-of-antifungal-resistance-in-filamentous-fungi
#13
Cheshta Sharma, Anuradha Chowdhary
Invasive mould infections due to Aspergillus species, Fusarium spp., Scedosporium spp. and other filamentous fungi remain a significant cause of morbidity and mortality in immunocompromised patients. Antifungal therapy is required for successful patient management; however, limited antifungal drugs and emergence of drug resistance pose a challenge to the clinicians for the effective management of the disease. The evolution of multidrug resistant strains due to selective pressure and the intrinsically resistant pathogenic species are a major concern...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705673/global-acquisition-of-genetic-materials-from-different-bacteria-into-the-staphylococcal-cassette-chromosome-elements-of-a-staphylococcus-epidermidis
#14
Huping Xue, Zhaowei Wu, Dandan Qiao, Chao Tong, Xin Zhao
Staphylococcus epidermidis has been suggested as a main reservoir of methicillin-resistant and virulence genes to facilitate evolution of Staphylococcus aureus as a successful pathogen. However, it remains a mystery where and how S. epidermidis obtains numerous genes to serve as the reservoir. A methicillin-resistant S. epidermidis isolate NW32 from a mastitic milk sample was sequenced and its staphylococcal cassette chromosome (SCC) elements were characterized in this study. The SCC composite island covered 3...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705672/role-of-vancomycin-in-the-treatment-of-bacteraemia-and-meningitis-caused-by-elizabethkingia-meningoseptica
#15
REVIEW
Shio-Shin Jean, Tai-Chin Hsieh, Yong-Zhong Ning, Po-Ren Hsueh
Elizabethkingia meningoseptica, a Gram-negative pathogen once deemed clinically insignificant, tends to cause infections amongst the low-birth-weight infants or immunocompromised patients. Previously, vancomycin was reported to cure a few patients with bacteraemia caused by E. meningoseptica. Nevertheless, some laboratory investigations also showed considerable discordance between in vitro vancomycin susceptibility results obtained by the disc diffusion and broth microdilution method against clinical E. meningoseptica isolates as determined by the criteria for staphylococci recommended by the Clinical and Laboratory Standards Institute (formerly, National Committee for Clinical Laboratory Standards)...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705671/antibiotic-resistance-in-west-africa-a-systematic-review-and-meta-analysis
#16
REVIEW
Kerlly J Bernabé, Céline Langendorf, Nathan Ford, Jean-Baptiste Ronat, Richard A Murphy
BACKGROUND: Growing data suggest that antibiotic-resistant bacterial infections are common in low and middle-income countries. This review summarizes the microbiology of key bacterial syndromes encountered in West Africa and estimates the prevalence of antimicrobial resistance (AMR) that could compromise first-line empirical treatment. METHODS: We systematically searched for studies reporting on the epidemiology of infection and AMR in West Africa. Within each syndrome, the pooled proportion and 95% confidence intervals were calculated for each pathogen-antibiotic pair, using random effects models...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705670/empiric-antibiotic-protocols-for-cancer-patients-with-neutropenia-a-single-center-study-of-treatment-efficacy-and-mortality-in-patients-with-bacteremia
#17
Eyal Kleinhendler, Matan J Cohen, Allon E Moses, Ora Paltiel, Jacob Strahilevitz, Amos Cahan
BACKGROUND: A number of empiric antibiotic treatment options for febrile neutropenia exist, yet there is no universally-accepted initial protocol. We aimed to assess the performance of a protocol (piperacillin, gentamicin and cefazolin) introduced over 40 years ago and compare its coverage against bacteria isolated from blood of neutropenic patients to that of various commonly used antibiotic treatment protocols. METHODS: Adults with neutropenia admitted between 2003 and 2012 to the hemato-oncologic departments, in whom blood cultures were taken on admission were included...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705669/activity-of-temocillin-against-ctx-m-producing-escherichia-coli-and-klebsiella-pneumoniae-from-germany
#18
LETTER
Michael Kresken, Barbara Körber-Irrgang, Yvonne Pfeifer, Guido Werner
No abstract text is available yet for this article.
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705668/in-vitro-activity-of-the-novel-fluorocycline-eravacycline-against-carbapenem-non-susceptible-acinetobacter-baumannii
#19
Harald Seifert, Danuta Stefanik, Joyce A Sutcliffe, Paul G Higgins
The activity of eravacycline was compared with anti-Acinetobacter reference antimicrobials against carbapenem non-susceptible Acinetobacter baumannii isolates associated with an acquired OXA or up-regulation of the intrinsic OXA-51-like enzyme. Antimicrobial susceptibility testing was performed by broth microdilution of 286 non-duplicate, carbapenem non-susceptible A. baumannii isolates to eravacycline, amikacin colistin, doxycycline, imipenem, levofloxacin, meropenem, minocycline, sulbactam, tigecycline, and tobramycin...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28705667/clinical-characteristics-of-bacteraemia-caused-by-burkholderia-cepacia-complex-species-and-antimicrobial-susceptibility-of-the-isolates-in-a-medical-centre-in-taiwan
#20
Ying-Chun Chien, Chun-Hsing Liao, Wang-Huei Sheng, Jung-Yien Chien, Yu-Tsung Huang, Chong-Jen Yu, Po-Ren Hsueh
This study investigated the clinical characteristics and outcomes of bacteraemia due to Burkholderia cepacia complex (BCC) species among 54 patients without cystic fibrosis from January 2013 to February 2015. BCC isolates were identified to the species level by the Bruker Biotyper MALDI-TOF MS system and by sequencing analysis of the 16S rRNA and recA genes. Antimicrobial susceptibilities of the isolates were determined by the agar dilution method. Sequencing of the recA gene in the 54 blood isolates revealed 37 (68...
July 10, 2017: International Journal of Antimicrobial Agents
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