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International Journal of Antimicrobial Agents

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https://www.readbyqxmd.com/read/29127051/genomic-analysis-of-in-vivo-acquired-resistance-to-colistin-and-rifampin-in-acinetobacter-baumannii
#1
Nadia Jaidane, Thierry Naas, Wejdene Mansour, Bechir Ben Radhia, Sofiene Jerbi, Noureddine Boujaafar, Olfa Bouallegue, Rémy A Bonnin
Acinetobacter baumannii is an opportunistic pathogen in health-care facilities responsible for nosocomial infections mostly in immune-compromised patients. Colistin resistance is increasingly reported worldwide in that species. We describe here in vivo selection of colistin and rifampin resistance in a carbapenem-resistant A. baumannii (Ab). Antimicrobial susceptibility testing, plasmid analysis, and Whole Genome Sequencing (WGS) were performed to fully characterize the resistome of AbS1 and AbS2 clinical isolates...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29127050/do-antibacterial-and-antifungal-combinations-have-better-activity-against-clinically-relevant-fusarium-species-in-vitro-synergism
#2
Tarcieli Pozzebon Venturini, Abdullah M S Al-Hatmi, Luana Rossato, Maria Isabel Azevedo, Jéssica Tairine Keller, Carla Weiblen, Janio Morais Santurio, Sydney Hartz Alves
The objective of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. against classic antifungals (amphotericin B [AMB], itraconazole [ITC], voriconazole [VRC] and caspofungin [CAS]) and to nonantifungal agents (amiodarone [AMD], doxycycline [DOX] and moxifloxacin [MXF]) using broth microdilution method. The combinations between these antifungal plus nonantifungal agents were also evaluated for the determination of FICI (fractional inhibitory concentration index) using the checkerboard technique...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29127049/predicting-mutant-selection-in-competition-experiments-with-ciprofloxacin-exposed-escherichia-coli
#3
David D Khan, Pernilla Lagerbäck, Christer Malmberg, Anders N Kristoffersson, Erik Gullberg, Cao Sha, Otto Cars, Dan I Andersson, Diarmaid Hughes, Elisabet I Nielsen, Lena E Friberg
Predicting competition between antibiotic susceptible wild-type and less susceptible mutant bacteria is valuable for understanding how drug concentrations influence emergence of resistance. Pharmacokinetic-pharmacodynamic (PKPD) models predicting the rate and extent of takeover of resistant bacteria during different antibiotic pressures can thereby be a valuable tool in improving treatment regimens. The aim of this study was to evaluate a previously developed mechanism-based PKPD model for its ability to predict in vitro mixed-population experiments with competition between E...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29127048/spread-of-mcr-1-5-in-the-community-an-emerging-threat
#4
LETTER
Yoshikazu Ishii, Kotaro Aoki, Shiro Endo, Hiroshi Kiyota, Tetsuji Aoyagi, Mitsuo Kaku, Robert A Bonomo, Kazuhiro Tateda
No abstract text is available yet for this article.
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29127047/heteroresistance-to-carbapenems-in-invasive-pseudomonas-aeruginosa-infections
#5
Jianchun He, Xiaojiong Jia, Shuangshuang Yang, Xiuyu Xu, Kunling Sun, Congya Li, Tianxiang Yang, Liping Zhang
Heteroresistance is not rare in a variety of microbes, but carbapenem heteroresistace (CHR) among invasive P. aeruginosa infections has not been thoroughly characterized to date. The objective of this study was to investigate the mechanisms, molecular epidemiology, and risk factors for invasive carbapenem heteroresistant P. aeruginosa (CHPA) infections between 2011 and 2015 in Chongqing, China. We observed a significant increase in rates of heteroresistance to IPM (IPM-HR) and MEM (MEM-HR) during the study period...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29122698/emergence-of-methicillin-resistant-staphylococcus-aureus-st398-in-pigs-in-china
#6
LETTER
Wei Li, Jian-Hua Liu, Xiu-Feng Zhang, Jing Wang, Zhen-Bao Ma, Lin Chen, Zhen-Ling Zeng
No abstract text is available yet for this article.
November 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29122697/early-administration-of-appropriate-antimicrobial-agent-to-improve-the-outcome-of-carbapenem-resistant-acinetobacter-baumannii-complex-bacteremic-pneumonia
#7
Seong Yeon Park, Eun Jung Lee, Tark Kim, Shi Nae Yu, Ki-Ho Park, Mi Suk Lee, Se Yoon Park, Min Hyok Jeon, Tae Hyong Kim, Eun Ju Choo
BACKGROUND: Carbapenem resistant Acinetobacter baumannii complex (CRABC) is an emerging pathogen that causes bloodstream infections and nosocomial pneumonia. This study aimed to describe the severe infection associated with CRABC bacteremic pneumonia and to investigate risk factors for 28-day mortality. METHODS: All patients ≥18 years of age with a CRABC bacteremic pneumonia were enrolled retrospectively at five teaching hospitals in South Korea. Empirical antimicrobial therapy was defined as appropriate if administration of at least one antimicrobial agent, to which the causative pathogen was susceptible, more than 48 hours, within 5 days of the onset of bacteremia...
November 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111435/pharmacodynamics-of-cefiderocol-a-novel-siderophore-cephalosporin-explored-in-a-pseudomonas-aeruginosa-neutropenic-murine-thigh-model
#8
Islam M Ghazi, Marguerite L Monogue, Masakatsu Tsuji, David P Nicolau
BACKGROUND: Cefiderocol is a siderophore cephalosporin that displays potent in vitro activity against multi-drug resistant (MDR) Gram-negative bacteria. We aimed to describe cefiderocol's pharmacokinetics, pharmacodynamics, and 24-hour efficacy using dose-ranging methods in the neutropenic murine thigh infection model. METHODS: Infection was established in neutropenic mice (administered cyclophosphamide 150 mg/kg and 100 mg/kg 4 and 1 days prior to inoculation respectively) with 8 Pseudomonas aeruginosa isolates (MIC range: 0...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111434/empiric-treatment-of-lower-urinary-tract-infections-in-the-face-of-spreading-multi-drug-resistance-in-vitro-study-of-nitroxoline-effectiveness
#9
A Sobke, O Makarewicz, M Baier, C Bär, W Pfister, S G Gatermann, M W Pletz, C Forstner
The spread of antimicrobial resistance challenges the empiric treatment in urinary tract infections (UTI). Among others, nitrofurantoin is recommended for first line treatment, but acceptance among clinicians is limited due to chronic nitrofurantoin-induced lung toxicity and insufficient coverage of Enterobacteriaceae other than Escherichia coli. Nitroxoline seems to be an alternative to nitrofurantoin due to its favourable safety profile but data on its current in vitro susceptibility are sparse. In this study susceptibility to nitroxoline was tested against 3,012 urinary clinical isolates (including multidrug-resistant bacteria and Candida spp...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111433/longitudinal-study-on-antimicrobial-consumption-and-resistance-in-rabbit-farming
#10
Fabrizio Agnoletti, Romina Brunetta, Luca Bano, Ilenia Drigo, Elena Mazzolini
Reliable indicators of antimicrobial consumption (AMC) measured with harmonized data and supported with indicators for antimicrobial resistance (AMR) at herd level are necessary to target antimicrobial misuse in food producing animals. To this scope in 2010-2015 we collected AMC data in 32 Italian industrial rabbit holdings weighted with semester production and standardized with animal daily dose (ADD). Herd level AMR against eight antimicrobials was assessed in E. coli, E. faecalis and E. hirae collected in 2014 and 2015...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111432/direct-determination-of-carbapenem-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-from-positive-blood-cultures-using-laser-scattering-technology
#11
Evgeny A Idelevich, Matthias Hoy, Dennis Knaack, Dennis Görlich, Georg Peters, Matthias Borowski, Karsten Becker
OBJECTIVE: Delays in appropriate antimicrobial treatment contribute to increased mortality of septic patients. We aimed to develop a methodology for detection of carbapenem resistance in Gram-negative bacteria directly from positive blood cultures (BCs). METHODS: Initially, meropenem-resistant Enterobacteriaceae (n=13) and Pseudomonas aeruginosa (n=32) isolates as well as the same numbers of meropenem-susceptible isolates were used to establish the detection of carbapenem resistance from agar cultures...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29097338/expansion-of-kpc-producing-klebsiella-pneumoniae-with-various-mgrb-mutations-giving-rise-to-colistin-resistance-the-role-of-isl3-on-plasmids
#12
Cesira Giordano, Simona Barnini, Constantinos Tsioutis, Monika A Chlebowicz, Effie V Scoulica, Achilleas Gikas, John W Rossen, Alexander W Friedrich, Erik Bathoorn
BACKGROUND: mcr-1 has been reported as first plasmid gene to confer colistin-resistance. In KPC-producing Klebsiella pneumoniae (KPC-KP) isolates, however, colistin resistance is rapidly emerging through other mechanisms. This is frequently the result of disruption of mgrB gene by insertion sequences, for instance ISL3. The aim of this study is to investigate the expansion of mgrB-mutated KPC-KP. In addition, we identify localization and targets of ISL3 sequences within the core and accessory genome of common KPC-KP lineages...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29107093/resveratrol-enhancement-on-survival-of-staphylococcus-aureus-under-levofloxacin-and-photodynamic-treatments
#13
Maira Gaspar Tosato, Patricia Schilardi, Mónica Fernández Lorenzo de Mele, Andrés H Thomas, Alejandro Miñan, Carolina Lorente
Reactive oxygen species (ROS) are an efficient tool to eradicate microorganisms, due to the capacity of these species to damage almost all types of biomolecules and to kill cells. The increment in the resistance mechanisms to antibiotics leads to the exploration of new strategies to eliminate microorganisms that involves production of ROS, such as superoxide anion (O2(•-)) and hydrogen peroxide (H2O2). ROS are produced during several antimicrobial treatments, including antibiotic and photodynamic therapies...
October 26, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29079213/virtual-special-section-new-challenges-in-antifungal-therapy
#14
EDITORIAL
Stéphane Ranque, Fadi Bittar
No abstract text is available yet for this article.
October 24, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29038088/first-description-of-rpsj-and-mepa-mutations-associated-with-tigecycline-resistance-in-staphylococcus-aureus-isolated-from-a-cystic-fibrosis-patient-during-antibiotic-therapy
#15
LETTER
M S Haim, S Di Gregorio, L Galanternik, S Lubovich, M Vázquez, A Bharat, R Zaheer, G R Golding, M Graham, G Van Domselaar, S T Cardona, M Mollerach
No abstract text is available yet for this article.
October 13, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29038087/integrons-in-enterobacteriaceae-diversity-distribution-and-epidemiology
#16
REVIEW
Megha Kaushik, Sanjay Kumar, Rajeev Kumar Kapoor, Jugsharan Singh Virdi, Pooja Gulati
Integrons are versatile gene acquisition system which allow efficient capturing of exogenous genes and ensure their expression. Various classes of integrons possessing wide variety of gene cassettes are ubiquitously distributed in enteric bacteria throughout the world. The epidemiology of the integrons associated multidrug resistance in Enterobacteriaceae is rapidly evolving. In the past two decades, the incidence of integrons in enteric bacteria has increased drastically with evolution of multiple gene cassettes, novel gene arrangements and complex chromosomal integrons like Salmonella genomic islands...
October 13, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29032113/accelerating-with-the-brakes-on
#17
LETTER
Berrie Meijer, Nanne K H de Boer
No abstract text is available yet for this article.
October 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29032112/dermal-pharmacokinetics-of-pyrazinamide-determined-by-microdialysis-sampling-in-rats
#18
Nivea M F Voelkner, Alexander Voelkner, Juliana Costa, Sherwin K B Sy, Juliane Hermes, Johanna Weitzel, Sebastian Morales, Hartmut Derendorf
Studies have demonstrated pyrazinamide's efficacy against stages of the parasite which causes cutaneous leishmaniasis. Although pyrazinamide is widely distributed to most fluids and tissues, the drug distribution that reaches the skin is unknown. The aim of this study was to investigate pyrazinamide pharmacokinetics in rat dermal tissue by dermal microdialysis. Skin pharmacokinetics were assessed by implanting a linear microdialysis probe in the dermis of ten rats. Additionally, blood samples were collected for assessing plasma pharmacokinetics...
October 12, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29030266/plasmid-mediated-doxycycline-resistance-in-a-yersinia-pestis-strain-isolated-from-a-rat
#19
Nicolas Cabanel, Christiane Bouchier, Minoarisoa Rajerison, Elisabeth Carniel
Emergence of antibiotic-resistant Y. pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar were previously identified and characterized. Both strains carried conjugative plasmids that conferred resistance to streptomycin or to multiple antibacterial drugs. Here we characterized a novel Y. pestis strain (IP2180H) that exhibited resistance to doxycycline. This strain was isolated from a rat in Antananarivo (Madagascar) in 1998. Resistance was carried by a conjugative plasmid (pIP2180H) homologous to pB71 from Salmonella enterica...
October 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29024775/deciphering-the-complete-deletion-of-the-mgrb-locus-in-an-unusual-colistin-resistant-klebsiella-pneumoniae-colonizing-the-gut-of-a-traveler-returning-from-india
#20
LETTER
Odette J Bernasconi, Valentina Donà, João Pires, Esther Kuenzli, Christoph Hatz, Francesco Luzzaro, Vincent Perreten, Andrea Endimiani
No abstract text is available yet for this article.
October 9, 2017: International Journal of Antimicrobial Agents
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