Read by QxMD icon Read

International Journal of Antimicrobial Agents

Jian-Mei Zhang, Qing Wang, Tong-Yan Han, Jian-Hua Liu, Xin-Xin Hu, Feng Qiao, Xin-Yi Yang, Cong-Ran Li, Xue-Fu You
Transfer of aac(6')-aph(2'') transposons mediating High-Level Gentamicin Resistance (HLGR) in Enterococcus faecalis caused a serious problem in clinic. But the factors affecting aac(6')-aph(2'') transfer was not elucidated. In the current study, we aimed to examine the genetic and molecular basis of HLGR in E. faecalis strains isolated in Beijing China, and to clarify the relationship between transfer efficiency of aac(6')-aph(2'') transposons and the transposon structures / locations. Totally 5 transposon structures were identified by PCR mapping of the corresponding transposon regions, including Tn5281-like nontruncated transposon, and four truncated transposons...
September 5, 2018: International Journal of Antimicrobial Agents
Lucile Dutreix, Clément Bernard, Camille Juin, Christine Imbert, Marion Girardot
Candida sp., especially C. albicans, is one of the main colonizers of the oral cavity. Due to its ability to form biofilms, it can be implicated in dental caries, periodontal disease or denture stomatitis. In biofilms, microbial cells are minimally impacted by conventional drugs. The aim of this study was to find new substances able to inhibit the adhesion of Candida species in order to prevent biofilm formation in the oral cavity. This study focused on the Rubus idaeus fruit, known for its richness in potentially antimicrobial tannins...
September 1, 2018: International Journal of Antimicrobial Agents
Bryan T Mogle, Jeffrey M Steele, Robert W Seabury, Utkarsh J Dang, Wesley D Kufel
Limited evidence exists evaluating pharmacokinetic thresholds for vancomycin efficacy and nephrotoxicity using non-Bayesian methods. The objective of this study was to evaluate 24-hour steady-state vancomycin area under the concentration-time curve (AUC24 ) thresholds for efficacy and nephrotoxicity in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia (MRSA-B) after implementing two-point pharmacokinetic therapeutic drug monitoring (TDM). A single-center, retrospective cohort study was performed that included adult patients admitted between June 1, 2016 - January 1, 2018 with MRSA-B treated with vancomycin for ≥72 hours...
August 31, 2018: International Journal of Antimicrobial Agents
Jian-Ming He, Shi-Chang Sun, Zhong-Lin Sun, Jie-Tao Chen, Qing Mu
Antimicrobial resistance is the greatest threat to the treatment of bacterial infectious diseases. The development of resistance-modifying agents represents a promising strategy to mitigate the spread of bacterial antibiotic resistance. A natural product, isovalerylshikonin (IVS), was isolated from traditional Chinese medicine Arnebia euchroma in this study, which exhibited marginal antibacterial activity against drug-resistant Staphylococcus aureus RN4220, with an MIC of 16 mg/L. In addition, a synergistic effect between IVS and streptomycin was detected by the microdilution antimicrobial checkerboard assay, with a reduction in the MIC of IVS by up to 32-fold against RN4220...
August 31, 2018: International Journal of Antimicrobial Agents
Paul-Louis Woerther, Raphaël Lepeule, Charles Burdet, Jean-Winoc Decousser, Étienne Ruppé, François Barbier
The on-going pandemic of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBLE) is responsible for a global rise in carbapenem consumption that may hasten the dissemination of carbapenemase-producing Enterobacteriaceae (CPE). Hence, carbapenem sparing through the use of alternative beta-lactams is increasingly considered as potential option in patients with ESBLE infections. Still, at the individual level, this strategy implies an in-depth understanding of how carbapenems and their alternatives impair the gut microbiota, especially the anaerobic bacteria and the colonization resistance (CR) that it confers...
August 31, 2018: International Journal of Antimicrobial Agents
Karolina A Lis, Corinna Kehrenberg, Annika Boulaaba, Maren von Köckritz-Blickwede, Sylvia Binder, Yangfang Li, Julia L Zimmermann, Yvonne Pfeifer, Birte Ahlfeld
OBJECTIVE: To investigate the impact of cold atmospheric pressure plasma (CAP) produced by a Surface-Micro-Discharge (SMD) plasma source as a new strategy to combat the transmission of five multidrug-resistant pathogens and Y. enterocolitica on typical hospital- and food-producing surfaces, like stainless steel. METHODS: Approximately 106 CFU/cm2 vancomycin-resistant Enterococcus (E.) faecium, methicillin-resistant Staphylococcus (S.) aureus, Klebsiella (K.) pneumoniae, Acinetobacter (A...
August 31, 2018: International Journal of Antimicrobial Agents
Farah Ben Tanfous, Anis Raddaoui, Yosra Chebbi, Wafa Achour
The aim of our retrospective study was to investigate the resistance determinants and the genetic relatedness of colistin-resistant Klebsiella pneumoniae isolates in the National Bone Marrow Transplant Center of Tunis (NBMTC) between 2002 and 2013. Colistin-resistant K. pneumoniae isolates were investigated. The minimal inhibitory concentration (MIC) of colistin was assessed using the UMIC broth microdilution kit. All isolates were screened by PCR assay for resistance genes: mcr-1, blaCTX-M1 , blaSHV , blaTEM , blaOXA-1 blaOXA-48 , blaKPC , blaIMP , blaVIM , blaNDM , blaGES , blaIMI and AmpC group as well as class 1, 2 and 3 integrons...
August 31, 2018: International Journal of Antimicrobial Agents
Han Zhong, Xian-Yuan Zhao, Zai-Li Zhang, Zhi-Chun Gu, Chi Zhang, Yuan Gao, Min Cui
Data on the efficacy and safety of ceftazidime/avibactam (CAZ-AVI) are limited. A systematic review and meta-analysis was conducted to clarify the role of CAZ-AVI for patients with serious Gram-negative bacterial infections. The PubMed, EMBASE and Cochrane Library databases were searched for randomised controlled trials (RCTs) and cohort studies involving CAZ-AVI. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a fixed- or random-effects model. Twelve articles (4951 patients) were included, consisting of nine RCTs and three observational studies comparing CAZ-AVI with other regimens, e...
August 30, 2018: International Journal of Antimicrobial Agents
Rong Xiang, Xiaolan Ye, Hongmei Tuo, Xiuzhong Zhang, Anyun Zhang, Changwei Lei, Yanxian Yang, Hongning Wang
No abstract text is available yet for this article.
August 30, 2018: International Journal of Antimicrobial Agents
Francesca Sisto, Maria Maddalena Scaltrito, Carla Masia, Arianna Bonomi, Valentina Coccè, Giuseppe Marano, Richard K Haynes, Alessandro Miani, Giampietro Farronato, Donatella Taramelli
No abstract text is available yet for this article.
August 29, 2018: International Journal of Antimicrobial Agents
Bruna Fuga Araújo, Sabrina Royer, Paola Amaral Campos, Melina Lorraine Ferreira, Iara Rossi Gonçalves, Luiz Gustavo Machado, Nilton Lincopan, Miriam Rodriguez Fernandes, Louise Teixeira Cerdeira, Deivid William da Fonseca Batistão, Paulo P Gontijo-Filho, Rosineide Marques Ribas
No abstract text is available yet for this article.
August 27, 2018: International Journal of Antimicrobial Agents
Didier Raoult
No abstract text is available yet for this article.
August 24, 2018: International Journal of Antimicrobial Agents
Shey-Ying Chen, Hao Lee, Xiao-Mei Wang, Tai-Fen Lee, Chun-Hsing Liao, Lee-Jene Teng, Po-Ren Hsueh
Staphylococcus argenteus has been increasingly reported. Evaluating the impact of S. argenteus infections on patient outcomes for future therapeutic and infection control decision-making is imperative. We conducted a retrospective study to investigate the prevalence of S. argenteus bacteraemia at a medical centre between 2010 and 2012. S. argenteus was identified based on the absence of the crtM gene and multilocus sequence analysis (MLST). The clinical characteristics between S. argenteus and S. aureus bacteraemia were compared...
August 24, 2018: International Journal of Antimicrobial Agents
Hassan E Eldesouky, Xiaoyan Li, Nader S Abutaleb, Haroon Mohammad, Mohamed N Seleem
Candida auris is an emerging multidrug-resistant pathogen that has been implicated in numerous outbreaks worldwide, with a notably high rate of mortality (∼60%). A significant challenge with treatment of these infections is C. auris is resistant to most antifungal drugs used clinically. Thus, finding co-drugs capable of overcoming resistance to frontline antifungal drugs is of prime clinical importance. Herein, we evaluated the ability of the combination of different sulfa drugs with azole antifungal drugs to inhibit the growth of azole-resistant C...
August 23, 2018: International Journal of Antimicrobial Agents
Hannah Lishman, Céire Costelloe, Susan Hopkins, Alan P Johnson, Russell Hope, Rebecca Guy, Berit Muller-Pebody, Alison Holmes, Paul Aylin
This study aimed to quantify the association between antibiotic prescribing for urinary tract infections (UTIs) and the incidence/antibiotic susceptibility of UTI-related Escherichia coli bacteraemia in adult women in England. A national ecological study was conducted with data aggregated at the GP practice level. The study population was all adult female patients (18+) with a reported UTI-related E. coli bacteraemia in England (2012-2014). Reports of bacteraemia from the national mandatory surveillance scheme were linked with E...
August 23, 2018: International Journal of Antimicrobial Agents
Sutthirat Srisuwan, Kate E Mackin, Dianna Hocking, Dena Lyras, Vicki Bennett-Wood, Supayang P Voravuthikunchai, Roy M Robins-Browne
The increasing incidence and severity of diarrhoea and colitis caused by Clostridium difficile, together with a high rate of relapse following treatment with currently recommended antimicrobials, calls for novel interventions. Rhodomyrtone, a bioactive compound derived from the leaves of the rose myrtle, Rhodomyrtus tomentosa, has demonstrated antibacterial activity against several Gram-positive bacteria. This study compared the in-vitro antimicrobial activity of rhodomyrtone on C. difficile with that of vancomycin, a recommended agent for the treatment of C...
August 23, 2018: International Journal of Antimicrobial Agents
Jenny Bischoff, Jürgen K Rockstroh
Direct acting antivirals (DAAs) have tremendously improved treatment of Hepatitis C virus (HCV) infections also in Human immunodeficiency virus (HIV) positive individuals. Curing HCV is of particular importance in HIV positive individuals as liver disease progression is accelerated in the course of concomitant HIV infection. Former challenges, such as safety and tolerability as well as reduced treatment uptake of a peginterferon (pegIFN) and ribavirin (RBV) based treatment have been overcome with the approval of DAAs...
August 23, 2018: International Journal of Antimicrobial Agents
Chih-Cheng Lai, Yi-Tsung Lin, Yu-Tzu Lin, Min-Chi Lu, Zhi-Yuan Shi, Yao-Shen Chen, Lih-Shinn Wang, Shu-Hui Tseng, Chao-Nan Lin, Yen-Hsu Chen, Wen-Chien Ko, Fu-Der Wang, Po-Ren Hsueh
In 2017, this nationwide surveillance was conducted to investigate the prevalence and clinical characteristics of patients with bacteraemia due to mcr-1-harboring Enterobacteriaceae and the presence of mcr-1-harboring Escherichia coli in pigs. Non-duplicate and consecutive bacterial isolates were collected from patients treated at 16 hospitals in Taiwan. All E. coli (n = 686) and Klebsiella pneumoniae (n = 673) isolates from humans were obtained from patients with bacteraemia; for Salmonella spp. (n = 221) isolates, 52...
August 23, 2018: International Journal of Antimicrobial Agents
Fernando Lázaro-Perona, Alma Sotillo, Paloma Troyano-Hernáez, Rosa Gómez-Gil, Ángela de la Vega-Bueno, Jesús Mingorance
Carbapenem-resistant Klebsiella pneumoniae (CRKP) have spread globally through tertiary hospitals. Many CRKP clinical isolates are multi-drug resistant and may become eventually pan-drug resistant (PDR). We present the closed genome of a pan-drug resistant VIM-1-producer K. pneumoniae strain (KP1050) obtained in a tertiary hospital . The isolate belonged to ST54 and had five extrachromosomal elements, four plasmids and a circular phage genome. Most resistance genes were located in two clusters borne by two of the plasmids, a class 1 integron that contained up to fourteen genes, including a VIM-1 metallo-beta-lactamase gene, and an IS26 transposon that contained a mobile element from A...
August 22, 2018: International Journal of Antimicrobial Agents
Clément Bernard, Noémie Renaudeau, Marie-Laure Mollichella, Nathalie Quellard, Marion Girardot, Christine Imbert
The aim of this study was to investigate the ability of Candida albicans and Cutibacterium acnes to grow together as a polymicrobial biofilm in vitro and to examine the influence of C. acnes on C. albicans susceptibility to micafungin. Mature 72h-old single-species biofilms of C. albicans and polymicrobial biofilms involving both C. albicans and C. acnes were formed in Brain Heart Infusion and observed by scanning electronic microscopy. 24h-old single-species and polymicrobial biofilms were treated for 24h by micafungin (concentrations ranging from 0...
August 22, 2018: International Journal of Antimicrobial Agents
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"