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International Journal of Antimicrobial Agents

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https://www.readbyqxmd.com/read/28219753/coexistence-of-mcr-1-and-ndm-9-in-a-clinical-carbapenem-resistant-escherichia-coli-isolate
#1
LETTER
Chih-Cheng Lai, Yin-Ching Chuang, Chi-Chung Chen, Hung-Jen Tang
No abstract text is available yet for this article.
February 17, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28193463/first-isolation-of-the-pan-azole-resistant-aspergillus-fumigatus-cyp51a-tr46-y121f-t289a-mutant-in-a-uk-patient
#2
LETTER
Caroline B Moore, Lily Novak-Frazer, Eavan Muldoon, Kenneth W Dunn, Rikesh Masania, Malcolm D Richardson, Riina Rautemaa-Richardson
No abstract text is available yet for this article.
February 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28189734/is-continuous-infusion-of-imipenem-always-the-best-choice
#3
Hana Suchánková, Michal Lipš, Karel Urbánek, Michael N Neely, Jan Strojil
Monte Carlo simulations allow prediction and comparison of concentration-time profiles arising from different dosing regimens in a defined population, provided a population pharmacokinetic model has been established. The aims of this study were to evaluate the population pharmacokinetics of imipenem in critically ill patients with hospital-acquired pneumonia (HAP) and to assess the probability of target attainment (PTA) and cumulative fraction of response (CFR) using EUCAST data. A two-compartment model based on a data set of 19 subjects was employed...
February 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28189735/myelosuppression-sparing-treatment-of-central-nervous-system-nocardiosis-in-a-multiple-myeloma-patient-utilising-a-tedizolid-based-regimen-a-case-report
#4
Aasiya Matin, Smriti Sharma, Pankaj Mathur, Senu K Apewokin
Central nervous system (CNS) nocardiosis is a recognised opportunistic infection in immunocompromised patients. Treatment involves prolonged institution of antibiotics, making oral agents a convenient and desired option. Unfortunately, devising an effective, well-tolerated antimicrobial for the duration required to treat CNS nocardiosis is challenging owing to treatment intolerance and toxicities. This report highlights myelosuppression-sparing treatment with an oral tedizolid-based regimen following a complicated course with standard agents...
February 8, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28188831/lipoteichoic-acid-synthesis-inhibition-in-combination-with-antibiotics-abrogates-growth-of-multidrug-resistant-enterococcus-faecium
#5
Fernanda L Paganelli, Tim van de Kamer, Ellen C Brouwer, Helen L Leavis, Neil Woodford, Marc J M Bonten, Rob J L Willems, Antoni P A Hendrickx
Enterococcus faecium is a multidrug-resistant (MDR) nosocomial pathogen causing significant morbidity in debilitated patients. New antimicrobials are needed to treat antibiotic-resistant E. faecium infections in hospitalised patients. E. faecium incorporates lipoteichoic acid (LTA) (1,3-polyglycerol-phosphate linked to glycolipid) in its cell wall. The small-molecule inhibitor 1771 [2-oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 2-naphtho[2,1-b]furan-1-ylacetate] specifically blocks the activity of Staphylococcus aureus LtaS synthase, which polymerises 1,3-glycerolphosphate into LTA polymers...
February 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28188830/in-vitro-activity-of-clarithromycin-in-combination-with-other-antimicrobial-agents-against-mycobacterium-abscessus-and-mycobacterium-massiliense
#6
Zhijian Zhang, Jie Lu, Min Liu, Yufeng Wang, Yanlin Zhao, Yu Pang
Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, including linezolid (LZD), moxifloxacin (MOX), amikacin (AMK) and tigecycline (TGC). A total of 40 M. abscessus complex isolates were studied, comprising 20 M. abscessus and 20 M. massiliense strains...
February 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28185946/decreased-tacrolimus-plasma-concentrations-during-hcv-therapy-a-drug-drug-interaction-or-is-there-an-alternative-explanation
#7
E J Smolders, S Pape, C T M M de Kanter, A P van den Berg, J P H Drenth, D M Burger
Chronic hepatitis C virus (HCV) infection can cause severe liver cirrhosis, for which liver transplantation is the only therapy. To prevent organ rejection, transplanted patients are treated with immunosuppressive agents. We describe two transplanted patients treated with tacrolimus who were simultaneously treated with direct-acting antivirals (DAAs) for their chronic HCV infection. No pharmacokinetic drug-drug interactions (DDIs) were expected between tacrolimus and the selected DAAs. However, in both patients, tacrolimus plasma concentrations decreased during HCV treatment...
February 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28167347/synergy-against-extensively-drug-resistant-acinetobacter-baumannii-in-vitro-by-two-old-antibiotics-colistin-and-chloramphenicol
#8
Wen-Juan Wei, Hai-Fei Yang
Combination antimicrobial therapy is an important option in the fight against Gram-negative 'superbugs'. This study systematically investigated the synergistic effect of colistin (CST) and chloramphenicol (CHL) in combination against extensively drug-resistant Acinetobacter baumannii (XDR-AB). The microtitre plate chequerboard assay was used to test synergy against 50 XDR-AB clinical strains. Then, three XDR-AB clinical isolates and the type strain A. baumannii ATCC 19606 were chosen for further synergy studies using time-kill assay, mutant prevention concentration (MPC) assay and real-time population analysis profile (PAP) assay...
February 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28167346/ciliates-promote-the-transfer-of-a-plasmid-encoding-blandm-5-from-escherichia-coli-isolated-from-a-hospital-in-japan-to-other-human-pathogens
#9
LETTER
Torahiko Okubo, Mizue Matushita, Yukiko Ohara, Junji Matsuo, Satoshi Oguri, Tatsuya Fukumoto, Kasumi Hayasaka, Kouzi Akizawa, Hitoshi Shibuya, Chikara Shimizu, Hiroyuki Yamaguchi
No abstract text is available yet for this article.
February 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28163137/resistance-to-polymyxins-in-gram-negative-organisms
#10
Katy Jeannot, Arnaud Bolard, Patrick Plésiat
Polymyxins have recently been re-introduced into the therapeutic arsenal to combat infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence of strains resistant to these last-resort drugs is becoming a critical issue in a growing number of countries. Both intrinsic and transferable mechanisms of polymyxin resistance have been characterised. These mechanisms as well as the epidemiological data regarding four relevant bacterial pathogens (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) are considered in this review...
February 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28163138/intrathecal-or-intraventricular-administration-of-colistin-vancomycin-and-amikacin-for-central-nervous-system-infections-in-neurosurgical-patients-in-an-intensive-care-unit
#11
LETTER
Angeliki Tsimogianni, Panagiotis Alexandropoulos, Vasiliki Chantziara, Aimilia Vassi, Georgia Micha, Fotini Lagiou, Efrosini Chinou, Georgios Michaloudis, Serafeim Georgiou
No abstract text is available yet for this article.
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28163136/safety-and-effectiveness-of-a-12-week-course-of-sofosbuvir-and-simeprevir%C3%A2-%C3%A2-%C3%A2-ribavirin-in-hcv-infected-patients-with-or-without-hiv-infection-a-multicentre-observational-study
#12
Giuseppe Bruno, Annalisa Saracino, Claudia Fabrizio, Luigia Scudeller, Eugenio Milano, Raffaele Dell'Acqua, Nicoletta Ladisa, Massimo Fasano, Salvatore Minniti, Giovanni Buccoliero, Alessandra Tartaglia, Adele Giammario, Michele Milella, Gioacchino Angarano
The combination of sofosbuvir and simeprevir ± ribavirin (SOF + SMV ± RBV) for hepatitis C virus (HCV) treatment has been associated with high rates of sustained virological response (SVR). Few data are available regarding this regimen in HIV/HCV co-infected patients. This study evaluated the effectiveness and safety of a 12-week course of SOF + SMV ± RBV in a cohort of HCV monoinfected and HIV/HCV co-infected individuals. HCV-infected patients, with or without HIV infection, receiving a 12-week course of SOF + SMV ± RBV in four Italian centres from February to October 2015, were included in this retrospective observational study...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28162983/activity-of-moxifloxacin-and-linezolid-against-mycobacterium-tuberculosis-in-combination-with-potentiator-drugs-verapamil-timcodar-colistin-and-sq109
#13
Gerjo J de Knegt, Aart van der Meijden, Corné P de Vogel, Rob E Aarnoutse, Jurriaan E M de Steenwinkel
Current treatment for tuberculosis (TB) is complicated by the emergence of multidrug resistant TB (MDR-TB). As a result, there is an urgent need for new powerful anti-TB regimens and novel strategies. In this study, we aimed to potentiate a moxifloxacin + linezolid backbone as treatment for MDR-TB with the efflux pump inhibitors verapamil and timcodar as well as with drugs that act on mycobacterial cell wall stability such as colistin and SQ109. Using a time-kill kinetics assay, the activities of moxifloxacin, linezolid, verapamil, timcodar, colistin and SQ109 as single drugs against Mycobacterium tuberculosis were evaluated...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28162982/revival-of-old-antibiotics-needs-the-state-of-evidence-and-expectations
#14
Hiba Zayyad, Noa Eliakim-Raz, Leonard Leibovici, Mical Paul
The gap between the emergence of antibiotic resistance and new antibiotic development has drawn attention to old antibiotics whose spectrum of coverage frequently comprises highly resistant bacteria. However, these antibiotics have frequently not undergone the structured process of antibiotic development of modern antibiotics, from pharmacokinetic/pharmacodynamic (PK/PD) studies establishing safe and effective dosing, establishment of susceptibility breakpoints, to clinical trials establishing clinical safety and effectiveness...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28161488/cold-atmospheric-pressure-plasma-elimination-of-clinically-important-single-and-mixed-species-biofilms
#15
Martina Modic, Neil P McLeod, J Mark Sutton, James L Walsh
Mixed-species biofilms reflect the natural environment of many pathogens in clinical settings and are highly resistant to disinfection methods. An indirect cold atmospheric-pressure air-plasma system was evaluated under two different discharge conditions for its ability to kill representative Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa) pathogens. Plasma treatment of individual 24-h-old biofilms and mixed-species biofilms that contained additional species (Enterococcus faecalis and Klebsiella pneumoniae) was considered...
February 1, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28161487/extended-spectrum-%C3%AE-lactamases-carbapenemases-and-the-mcr-1-gene-is-there-a-historical-link
#16
EDITORIAL
Mohamed Rhouma, Ann Letellier
The plasmid mediated mcr-1 gene encoding for Enterobacteriaceae colistin resistance has been recently identified across five continents. The objective of the present study was to trace historical events concerning the discovery and emergence of the mcr-1 gene along with ESBL and carbapenemase genes since several studies have reported identifying mcr-1 genes among Extended-Spectrum β-Lactamases (ESBL) and/or carbapenemase producing Escherichia coli. A retrospective study reported the identification of the mcr-1 gene in E...
February 1, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28159657/dose-optimisation-of-voriconazole-with-therapeutic-drug-monitoring-in-children-a-single-centre-experience-in-china
#17
Liang Liu, Xing Zhou, Tingting Wu, Hongliang Jiang, Sitao Yang, Yang Zhang
The pharmacokinetic profile of voriconazole is highly variable, rendering inconsistent and/or inadequate dosing, especially in children <2 years old. A retrospective analysis was performed in children receiving voriconazole with at least one plasma trough level (Ctrough) monitored. Statistical analyses were performed to examine the dose-exposure relationship as well as other factors potentially affecting voriconazole Ctrough in children of different ages. A total of 107 paediatric patients were included, of whom 75 were <2 years old...
January 31, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28159656/influence-of-different-proton-pump-inhibitors-on-the-pharmacokinetics-of-voriconazole
#18
Fang Qi, Liqin Zhu, Na Li, Tingyue Ge, Gaoqi Xu, Shasha Liao
This study aimed to determine the influence of proton pump inhibitors (PPIs) on the pharmacokinetics of voriconazole and to characterise potential drug-drug interactions (DDIs) between voriconazole and various PPIs (omeprazole, esomeprazole, lansoprazole and rabeprazole). Using adjusted physicochemical data and the pharmacokinetic (PK) parameters of voriconazole and PPIs, physiologically based pharmacokinetic (PBPK) models were built and were verified in healthy subjects using GastroPlus(TM) to predict the plasma concentration-time profiles of voriconazole and PPIs...
January 31, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28159655/screening-a-repurposing-library-for-potentiators-of-antibiotics-against-staphylococcus-aureus-biofilms
#19
Freija Van den Driessche, Gilles Brackman, Rosalie Swimberghe, Petra Rigole, Tom Coenye
Staphylococcus aureus biofilms are involved in a wide range of infections that are extremely difficult to treat with conventional antibiotic therapy. We aimed to identify potentiators of antibiotics against mature biofilms of S. aureus Mu50, a methicillin-resistant and vancomycin-intermediate-resistant strain. Over 700 off-patent drugs from a repurposing library were screened in combination with vancomycin in a microtitre plate (MTP)-based biofilm model system. This led to the identification of 25 hit compounds, including four phenothiazines among which thioridazine was the most potent...
January 31, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28153476/in-vitro-and-in-silico-analysis-of-the-efficiency-of-tetrahydropyridines-as-drug-efflux-inhibitors-in-escherichia-coli
#20
Lande Silva, Lillian Lucas Carrion, Andrea von Groll, Sofia Santos Costa, Elisabete Junqueira, Daniela Fernandes Ramos, Jéssica Cantos, Vinicius Rosa Seus, Isabel Couto, Liana da Silva Fernandes, Hélio Gauze Bonacorso, Marcos Antônio Pinto Martins, Nilo Zanatta, Miguel Viveiros, Karina S Machado, Pedro Eduardo Almeida da Silva
The objectives of this study were to evaluate tetrahydropyridine derivatives as efflux inhibitors and to understand the mechanism of action of the compounds by in silico studies. Minimum inhibitory concentration (MIC) determination, fluorometric methods and docking simulations were performed. The compounds NUNL02, NUNL09 and NUNL10 inhibited efflux, and NUNL02 is very likely a substrate of the transporter protein AcrB. Docking studies suggested that the mechanism of action could be by competition with substrate for binding sites and protein residues...
January 30, 2017: International Journal of Antimicrobial Agents
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