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International Journal of Antimicrobial Agents

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https://www.readbyqxmd.com/read/28093208/selective-reporting-of-antibiotic-susceptibility-test-results-in-european-countries-an-escmid-cross-sectional-survey
#1
Céline Pulcini, Gianpiero Tebano, Nico T Mutters, Evelina Tacconelli, Emmanuelle Cambau, Gunnar Kahlmeter, Vincent Jarlier
Selective reporting of antibiotic susceptibility test (AST) results is one possible laboratory-based antibiotic stewardship intervention. The primary aim of this study was to identify where and how selective reporting of AST results is implemented in Europe both in inpatient and in outpatient settings. An ESCMID cross-sectional, self-administered, internet-based survey was conducted among all EUCIC (European Committee on Infection Control) or EUCAST (European Committee on Antimicrobial Susceptibility Testing) national representatives in Europe and Israel...
January 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28089172/metal-oxide-nanoparticles-as-antimicrobial-agents-a-promise-for-the-future
#2
REVIEW
Azhwar Raghunath, Ekambaram Perumal
Microbial infectious diseases are a global threat to human health. Excess and improper use of antibiotics has created antimicrobial-resistant microbes that can defy clinical treatment. The hunt for safe and alternate antimicrobial agents is on in order to overcome such resistant micro-organisms, and the birth of nanotechnology offers promise to combat infectious organisms. Over the past two decades, metal oxide nanoparticles (MeO-NPs) have become an attractive alternative source to combat microbes that are highly resistant to various classes of antibiotics...
January 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28081925/detection-of-mcr-1-encoding-plasmid-mediated-colistin-resistant-salmonella-isolates-from-human-infection-in-denmark
#3
LETTER
Mia Torpdahl, Henrik Hasman, Eva Litrup, Robert L Skov, Eva M Nielsen, Anette M Hammerum
No abstract text is available yet for this article.
January 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28069325/mrsa-usa300-usa300-lv-and-st5-iv-in-pigs-cuba
#4
LETTER
Michel Baez, Alexandra Collaud, Ivette Espinosa, Vincent Perreten
No abstract text is available yet for this article.
January 3, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28040408/polymyxin-b-in-combination-with-meropenem-against-carbapenemase-producing-klebsiella-pneumoniae-pharmacodynamics-and-morphological-changes
#5
Rajnikant Sharma, Saloni Patel, Cely Abboud, John Diep, Neang S Ly, Jason M Pogue, Keith S Kaye, Jian Li, Gauri G Rao
Combination therapy provides a useful therapeutic approach to overcome resistance until new antibiotics become available. In this study, the pharmacodynamics, including the morphological effects, of polymyxin B (PMB) and meropenem alone and in combination against KPC-producing Klebsiella pneumoniae clinical isolates was examined. Ten clinical isolates were obtained from patients undergoing treatment for mediastinitis. KPCs were identified and MICs were measured using microbroth dilution. Time-kill studies were conducted over 24 h with PMB (0...
December 23, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28038960/use-of-whole-genome-sequencing-data-to-analyze-23s-rrna-mediated-azithromycin-resistance
#6
Steven R Johnson, Yonatan Grad, A Jeanine Abrams, Kevin Pettus, David L Trees
The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of the 23S rRNA gene and the copy number effect on 50S ribosome-mediated azithromycin resistance. Isolates that were predicted to contain four mutated copies were accurately identified compared with the results of direct sequencing...
December 19, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28038961/determinants-of-gentamicin-concentrations-in-critically-ill-patients-a-population-pharmacokinetic-analysis
#7
Caspar J Hodiamont, Nicole P Juffermans, Catherine S C Bouman, Menno D de Jong, Ron A A Mathôt, Reinier M van Hest
When treating critically ill patients with gentamicin for severe infection, peak concentrations (Cmax) determine clinical efficacy and trough concentrations (Cmin) determine toxicity. Despite administration of body weight-standardised starting doses, a wide range of Cmax is generally observed. Furthermore, in therapeutic drug monitoring, several measures of renal function are used to predict appropriate Cmin and gentamicin dosing intervals, but the most accurate predictor is not known. This study aimed to quantify the impact of several patient parameters on gentamicin Cmax values and to determine which measure of renal function best predicts gentamicin clearance (CL)...
December 16, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28040409/antifungal-effects-of-phytocompounds-on-candida-species-alone-and-in-combination-with-fluconazole
#8
REVIEW
Mengjiao Lu, Tao Li, Jianjian Wan, Xiuyun Li, Lei Yuan, Shujuan Sun
Invasive fungal infections caused by Candida spp. remain the most predominant nosocomial fungal infections. Owing to the increased use of antifungal agents, resistance of Candida spp. to antimycotics has emerged frequently, especially to fluconazole (FLC). To cope with this issue, new efforts have been dedicated to discovering novel antimycotics or new agents that can enhance the susceptibility of Candida spp. to existing antimycotics. The secondary metabolites of plants represent a large library of compounds that are important sources for new drugs or compounds suitable for further modification...
December 15, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28038962/confirming-model-predicted-pharmacokinetic-interactions-between-bedaquiline-and-lopinavir-ritonavir-or-nevirapine-in-patients-with-hiv-and-drug-resistant-tuberculosis
#9
Margreke J E Brill, Elin M Svensson, Mishal Pandie, Gary Maartens, Mats O Karlsson
Bedaquiline and its metabolite M2 are metabolised by CYP3A4. The antiretrovirals ritonavir-boosted lopinavir (LPV/r) and nevirapine inhibit and induce CYP3A4, respectively. Here we aimed to quantify nevirapine and LPV/r drug-drug interaction effects on bedaquiline and M2 in patients co-infected with HIV and multidrug-resistant tuberculosis (MDR-TB) using population pharmacokinetic (PK) analysis and compare these with model-based predictions from single-dose studies in subjects without TB. An observational PK study was performed in three groups of MDR-TB patients during bedaquiline maintenance dosing: HIV-seronegative patients (n = 17); and HIV-infected patients using antiretroviral therapy including nevirapine (n = 17) or LPV/r (n = 14)...
December 14, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27989379/epidemiology-of-invasive-aspergillosis-and-azole-resistance-in-patients-with-acute-leukaemia-the-sepia-study
#10
Philipp Koehler, Axel Hamprecht, Oliver Bader, Isabelle Bekeredjian-Ding, Dieter Buchheidt, Gottfried Doelken, Johannes Elias, Gerhard Haase, Corinna Hahn-Ast, Meinolf Karthaus, Alexander Kekulé, Peter Keller, Michael Kiehl, Stefan W Krause, Carolin Krämer, Silke Neumann, Holger Rohde, Paul La Rosée, Markus Ruhnke, Philippe Schafhausen, Enrico Schalk, Katrin Schulz, Stefan Schwartz, Gerda Silling, Peter Staib, Andrew Ullmann, Maria Vergoulidou, Thomas Weber, Oliver A Cornely, Maria J G T Vehreschild
Invasive aspergillosis (IA) is a serious hazard to high-risk haematological patients. There are increasing reports of azole-resistant Aspergillus spp. This study assessed the epidemiology of IA and azole-resistant Aspergillus spp. in patients with acute leukaemia in Germany. A prospective multicentre cohort study was performed in German haematology/oncology centres. The incidence of probable and proven aspergillosis according to the revised EORTC/MSG criteria was assessed for all patients with acute leukaemia [acute myeloid leukaemia (AML) and acute lymphoblastic leukaemia (ALL)]...
December 12, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28012683/might-real-time-pharmacokinetic-pharmacodynamic-optimisation-of-high-dose-continuous-infusion-meropenem-improve-clinical-cure-in-infections-caused-by-kpc-producing-klebsiella-pneumoniae
#11
Federico Pea, Paola Della Siega, Piergiorgio Cojutti, Assunta Sartor, Massimo Crapis, Claudio Scarparo, Matteo Bassetti
The effect of real-time pharmacokinetic/pharmacodynamic (PK/PD) optimisation of high-dose continuous-infusion meropenem on the clinical outcome of patients receiving combination antimicrobial therapy for treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp) infections was retrospectively assessed. Data for all patients with KPC-Kp-related infections who received antimicrobial combination therapy containing high-dose continuous-infusion meropenem optimised by means of therapeutic drug monitoring (TDM) were retrieved...
December 8, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27993526/first-report-of-klebsiella-pneumoniae-carbapenemase-producing-k-pneumoniae-sternum-osteomyelitis-relapsing-6-years-after-mediastinitis-following-cardiac-surgery
#12
LETTER
C S Abboud, L Miglioli, A P Romero, A S Ibanes, D Della Togna, R C Pereira, C A M Contreras, J Monteiro
No abstract text is available yet for this article.
December 6, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27986332/first-report-of-the-macrolide-efflux-genetic-assembly-mega-element-in-haemophilus-parainfluenzae
#13
LETTER
Andrea Endimiani, Aurélie Allemann, Daniel Wüthrich, Agnese Lupo, Markus Hilty
No abstract text is available yet for this article.
December 2, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27979501/amphotericin-b-nebulisation-for-invasive-pulmonary-aspergillosis-prophylaxis-the-conflict-of-ideality-and-reality
#14
LETTER
Yuetian Yu, Cheng Zhu, Chunyan Liu, Yuan Gao
No abstract text is available yet for this article.
December 2, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27979500/clinical-experience-with-ceftazidime-avibactam-in-patients-with-severe-infections-including-meningitis-and-lung-abscesses-caused-by-extensively-drug-resistant-pseudomonas-aeruginosa
#15
LETTER
Marc Xipell, Marta Bodro, Francesc Marco, Ricardo A Losno, Celia Cardozo, Alex Soriano
No abstract text is available yet for this article.
December 2, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27939093/susceptibility-to-cephalosporin-combinations-and-aztreonam-avibactam-among-third-generation-cephalosporin-resistant-enterobacteriaceae-recovered-on-hospital-admission
#16
Alexander Mischnik, Philipp Baumert, Axel Hamprecht, Anna Rohde, Silke Peter, Susanne Feihl, Johannes Knobloch, Hanna Gölz, Axel Kola, Birgit Obermann, Christiane Querbach, Matthias Willmann, Friedemann Gebhardt, Evelina Tacconelli, Petra Gastmeier, Harald Seifert, Winfried V Kern
As part of the multicentre Antibiotic Therapy Optimisation Study (ATHOS), minimum inhibitory concentrations (MICs) were determined for cephalosporins alone and in combination with the β-lactamase inhibitors tazobactam, clavulanic acid and avibactam against third-generation cephalosporin-resistant Escherichia coli, Klebsiella spp. and Enterobacter spp. isolates collected in German hospitals. MIC50/90 values were 0.25-4 mg/L for cefepime/tazobactam, 0.25-2 mg/L for ceftazidime/avibactam, 0.125-0.5 mg/L for ceftaroline/avibactam, 0...
November 28, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27939092/prosthetic-joints-shining-lights-on-challenging-blind-spots
#17
EDITORIAL
Kordo Saeed, Matthew Dryden, Matteo Bassetti, Eric Bonnet, Emilio Bouza, Monica Chan, Nick Cortes, Joshua S Davis, Silvano Esposito, Gérard Giordano, Ian Gould, David Hartwright, David Lye, Mercedes Marin, Rhidian Morgan-Jones, Francisco Lajara-Marco, Elda Righi, Carlo Luca Romano, John Segreti, Serhat Unal, Rhodri Llywelyn Williams, Ata Nevzat Yalcin
No abstract text is available yet for this article.
November 28, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27939091/understanding-the-acute-inflammatory-response-to-pseudomonas-aeruginosa-infection-differences-between-susceptible-and-multidrug-resistant-strains-in-a-mouse-peritonitis-model
#18
Silvia Gómez-Zorrilla, Laura Calatayud, Carlos Juan, Gabriel Cabot, Fe Tubau, Antonio Oliver, Maria Angeles Dominguez, Javier Ariza, Carmen Peña
The increasing emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa strains is associated with the spread of a few international epidemic clones called high-risk clones. The existence of a fitness cost associated with multidrug resistance remains unclear, and little is known about the host inflammatory response in acute P. aeruginosa infections. This study aimed to investigate how the inflammatory response occurs in the most relevant high-risk clones and to compare the process with that recorded in clinical susceptible isolates...
November 28, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28012685/pnca-mutations-are-associated-with-slower-sputum-conversion-during-standard-treatment-of-multidrug-resistant-tuberculosis
#19
Xubin Zheng, Zhu Ning, Francis Drobniewski, Jingyong Yang, Qun Li, Zhengdong Zhang, Yi Hu
Despite the strong association between drug resistance and genetic mutations, the value of molecular diagnosis of drug resistance to guide the treatment of multidrug-resistant tuberculosis (MDR-TB) remains unclear. This is particularly relevant in resource-limited areas where it is difficult to perform drug susceptibility testing (DST). Here we investigated the association between drug susceptibility phenotypes and genotypes and treatment outcomes in patients with MDR-TB. This study enrolled 74 consecutive patients with confirmed MDR-TB between 2010 and 2011, and outcomes were followed-up over the 24-month treatment course...
November 24, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28012684/bioavailability-of-voriconazole-in-hospitalised-patients
#20
Anette Veringa, Sanne Geling, Lambert F R Span, Karin M Vermeulen, Jan G Zijlstra, Tjip S van der Werf, Jos G W Kosterink, Jan-Willem C Alffenaar
An important element in antimicrobial stewardship programmes is early switch from intravenous (i.v.) to oral antimicrobial treatment, especially for highly bioavailable drugs. The antifungal agent voriconazole is available both in i.v. and oral formulations and bioavailability is estimated to be >90% in healthy volunteers, making this drug a suitable candidate for such a transition. Recently, two studies have shown that the bioavailability of voriconazole is substantially lower in patients. However, for both studies various factors that could influence the voriconazole serum concentration, such as inflammation, concomitant intake of food with oral voriconazole, and gastrointestinal complications, were not included in the evaluation...
November 23, 2016: International Journal of Antimicrobial Agents
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