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European Psychiatry: the Journal of the Association of European Psychiatrists

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https://www.readbyqxmd.com/read/27855309/evidence-of-an-epistatic-effect-between-dysbindin-1-and-neuritin-1-genes-on-the-risk-for-schizophrenia-spectrum-disorders
#1
C Prats, B Arias, J Moya-Higueras, E Pomarol-Clotet, M Parellada, A González-Pinto, V Peralta, M I Ibáñez, M Martín, L Fañanás, M Fatjó-Vilas
BACKGROUND: The interest in studying gene-gene interactions is increasing for psychiatric diseases such as schizophrenia-spectrum disorders (SSD), where multiple genes are involved. Dysbindin-1 (DTNBP1) and Neuritin-1 (NRN1) genes have been previously associated with SSD and both are involved in synaptic plasticity. We aimed to study whether these genes show an epistatic effect on the risk for SSD. METHODS: The sample comprised 388 SSD patients and 397 healthy subjects...
November 14, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27855308/a-longitudinal-mirror-image-assessment-of-morbidity-in-bipolar-disorder
#2
D J Martino, C Samamé, E Marengo, A Igoa, M Scápola, S A Strejilevich
BACKGROUND: Evidence about the clinical course of bipolar disorder is inconsistent and limited. The aim of this study was to assess changes in morbidity in patients with bipolar disorder along a mean follow-up period of 80months. METHODS: Based on a mirror-image design, the follow-up period of each patient was divided into two halves. Then, three measures of morbidity - number of affective episodes, time spent ill, and cycle length - were recorded and compared between each half of the follow-up period...
November 14, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837673/institutional-abuse-characteristics-of-victims-perpetrators-and-organsations-a-systematic-review
#3
Y S Kamavarapu, Michael Ferriter, S Morton, B Völlm
BACKGROUND: Abuse of vulnerable adults in institutional settings has been reported from various countries; however, there has been no systematic review of the characteristics of the victims and their abusers. Our aim was to identify and synthesise the literature on victims, perpetrators and institutions where abuse occured in order to inform interventions to prevent such abuse. METHODS: Searches of MEDLINE (OVID), CINHAL (EBSCO), EMBASE (OVID) and PsychINFO (OVID) databases identified 4279 references...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837672/correlates-of-postpartum-depression-in-first-time-mothers-without-previous-psychiatric-contact
#4
S M Sylvén, T P Thomopoulos, N Kollia, M Jonsson, A Skalkidou
BACKGROUND: Postpartum depression (PPD) is a common disorder after childbirth. The strongest known predictors are a history of depression and/or a history of PPD. However, for a significant proportion of women, PPD constitutes their first depressive episode. This study aimed to gain further insight into the risk factors for PPD in first time mothers without previous psychiatric contact. METHODS: Women delivering in Uppsala University Hospital, Sweden, from May 2006 to June 2007, were asked to participate and filled out questionnaires five days and six weeks postpartum, containing inter alia the Edinburgh Postnatal Depression Scale (EPDS)...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837671/d-cycloserine-addition-to-exposure-sessions-in-the-treatment-of-patients-with-obsessive-compulsive-disorder
#5
A S de Leeuw, H J G M van Megen, R S Kahn, H G M Westenberg
BACKGROUND: Preliminary studies have shown that the addition of the partial NMDA-agonist d-cycloserine (DCS) might be promising in enhancing the results of exposure therapy in obsessive-compulsive disorder (OCD). We examined the effect of DCS addition to exposure therapy in a somewhat larger sample of OCD patients with special attention to subgroups, because of the heterogeneity of OCD. METHODS: A randomized, double-blind, placebo controlled trial was conducted in 39 patients with OCD...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837670/brain-derived-neurotrophic-factor-bdnf-and-gray-matter-volume-in-bipolar-disorder
#6
S Poletti, V Aggio, T A Hoogenboezem, O Ambrée, H de Wit, A J M Wijkhuijs, C Locatelli, C Colombo, V Arolt, H A Drexhage, F Benedetti
INTRODUCTION: Bipolar Disorder (BD) is a severe psychiatric condition characterized by grey matter (GM) volumes reduction. Neurotrophic factors have been suggested to play a role in the neuroprogressive changes during the illness course. In particular peripheral brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in BD. The aim of our study was to investigate if serum levels of BDNF are associated with GM volumes in BD patients and healthy controls (HC)...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837669/cognitive-remediation-and-functional-improvement-in-schizophrenia-is-it-a-matter-of-size
#7
M Bosia, M Buonocore, M Bechi, M Spangaro, A Pigoni, M Croci, F Cocchi, C Guglielmino, L Bianchi, E Smeraldi, R Cavallaro
BACKGROUND: Cognitive Remediation represents the best available tool to treat cognitive deficits in schizophrenia and evidence suggests an effect also on global functioning. However, the relationship between cognitive and functional improvement is not yet fully elucidated: do cognitive changes need to be of a definite size and/or encompass a certain number of domains in order to impact on daily functioning? This study aims to explore the role of cognitive improvement, evaluated both quantitatively and qualitatively through the use of Italian equivalent scores, on the daily functioning of patients...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837668/adjustment-disorder-empirical-study-of-a-new-diagnostic-concept-for-icd-11-in-the-general-population-in-lithuania
#8
P Zelviene, E Kazlauskas, J Eimontas, A Maercker
OBJECTIVE: Adjustment disorder (AD) is one of the most debated diagnoses in psychiatry since it has been recognised as vaguely defined and causing a lot of difficulties in clinical practice. We aimed to analyse the structure of adjustment disorder based on International Classification of Diseases (ICD)-11 proposals by the WHO ICD-11 Working Group on the Classification of Disorders Specifically Associated with Stress in the general population in Lithuania. Three structural models of adjustment disorder were tested using Confirmatory Factor Analysis (CFA)...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837667/association-study-of-arcuate-nucleus-neuropeptide-y-neuron-receptor-gene-variation-and-serum-npy-levels-in-clozapine-treated-patients-with-schizophrenia
#9
J-P Klemettilä, O Kampman, A Solismaa, L-P Lyytikäinen, N Seppälä, M Viikki, M Hämäläinen, E Moilanen, N Mononen, T Lehtimäki, E Leinonen
BACKGROUND: Antipsychotic-induced weight gain (AIWG) leads to metabolic consequences and comorbidity, social stigmatization and nonadherence in patients with schizophrenia. Neuropeptide Y (NPY) has an important role in appetite and body weight regulation. Associations between AIWG and serum NPY levels, and genetic polymorphisms (SNPs) associated with its serum levels have been little studied in these patients. SUBJECTS AND METHODS: Associations between serum NPY concentration and other metabolic and inflammatory markers, and 215 SNPs in 21 genes (NPY gene, NPY receptor genes and genes encoding arcuate nucleus NPY neuron receptors) were studied in 180 patients with schizophrenia on clozapine treatment...
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27837666/treatment-guidelines-for-depression-greater-emphasis-on-physical-activity-is-needed
#10
EDITORIAL
M Hallgren, B Stubbs, D Vancampfort, A Lundin, P Jääkallio, Y Forsell
No abstract text is available yet for this article.
November 9, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27821355/fatty-acid-composition-of-the-postmortem-corpus-callosum-of-patients-with-schizophrenia-bipolar-disorder-or-major-depressive-disorder
#11
K Hamazaki, M Maekawa, T Toyota, B Dean, T Hamazaki, T Yoshikawa
BACKGROUND: Studies investigating the relationship between n-3 polyunsaturated fatty acid (PUFA) levels and psychiatric disorders have thus far focused mainly on analyzing gray matter, rather than white matter, in the postmortem brain. In this study, we investigated whether PUFA levels showed abnormalities in the corpus callosum, the largest area of white matter, in the postmortem brain tissue of patients with schizophrenia, bipolar disorder, or major depressive disorder. METHODS: Fatty acids in the phospholipids of the postmortem corpus callosum were evaluated by thin-layer chromatography and gas chromatography...
November 4, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27816610/forward-psychiatry%C3%A2-%C3%A2-early-intervention-for-mental-health-problems-among-uk-armed-forces-in-afghanistan
#12
N Jones, N T Fear, S Wessely, G Thandi, N Greenberg
BACKGROUND: This observational study examined return to duty (RTD) rates following receipt of early mental health interventions delivered by deployed mental health practitioners. METHOD: In-depth clinical interviews were conducted among 975 UK military personnel referred for mental health assessment whilst deployed in Afghanistan. Socio-demographic, military, operational, clinical and therapy outcomes were recorded in an electronic health record database. Rates and predictors of EVAC were the main outcomes examined using adjusted binary logistic regression analyses...
November 3, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810618/cognitive-behavioral-therapy-for-compulsive-buying-behavior-predictors-of-treatment-outcome
#13
R Granero, F Fernández-Aranda, G Mestre-Bach, T Steward, M Baño, Z Agüera, N Mallorquí-Bagué, N Aymamí, M Gómez-Peña, M Sancho, I Sánchez, J M Menchón, V Martín-Romera, S Jiménez-Murcia
BACKGROUND: Compulsive buying behavior (CBB) is receiving increasing consideration in both consumer and psychiatric-epidemiological research, yet empirical evidence on treatment interventions is scarce and mostly from small homogeneous clinical samples. OBJECTIVES: To estimate the short-term effectiveness of a standardized, individual cognitive behavioral therapy intervention (CBT) in a sample of n=97 treatment-seeking patients diagnosed with CBB, and to identify the most relevant predictors of therapy outcome...
October 31, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810617/why-so-glumm-detecting-depression-clusters-through-graphing-lifestyle-environs-using-machine-learning-methods-glumm
#14
J F Dipnall, J A Pasco, M Berk, L J Williams, S Dodd, F N Jacka, D Meyer
BACKGROUND: Key lifestyle-environ risk factors are operative for depression, but it is unclear how risk factors cluster. Machine-learning (ML) algorithms exist that learn, extract, identify and map underlying patterns to identify groupings of depressed individuals without constraints. The aim of this research was to use a large epidemiological study to identify and characterise depression clusters through "Graphing lifestyle-environs using machine-learning methods" (GLUMM). METHODS: Two ML algorithms were implemented: unsupervised Self-organised mapping (SOM) to create GLUMM clusters and a supervised boosted regression algorithm to describe clusters...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810616/exposure-to-tobacco-smoke-in-utero-or-during-early-childhood-and-risk-of-hypomania-prospective-birth-cohort-study
#15
D F Mackay, J J Anderson, J P Pell, S Zammit, D J Smith
OBJECTIVES: Using data from a prospective birth cohort, we aimed to test for an association between exposure to tobacco smoke in utero or during early development and the experience of hypomania assessed in young adulthood. METHODS: We used data on 2957 participants from a large birth cohort (Avon longitudinal study of parents and children [ALSPAC]). The primary outcome of interest was hypomania, and the secondary outcome was "hypomania plus previous psychotic experiences (PE)"...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810615/attentional-focus-moderates-the-relationship-between-attention-to-threat-bias-and-delusion-like-experiences-in-healthy-adults
#16
K Prochwicz, J Kłosowska
BACKGROUND: The role of cognitive biases in delusion and delusion-like experiences has been widely investigated in recent years. However, little is known about individual differences, which may influence association between cognitive biases and formation of delusional beliefs. The aim of this study was to examine the moderating effect of self-reported attentional control on the relationship between attention to threat bias (ATB) and delusion-like experiences (DLEs) in healthy adults. METHODS: Participants (n=138) completed the Davos Assessment of the Cognitive Biases Scale (DACOBS), the Attentional Control Scale (ACS) and the Peters et al...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810614/are-major-depression-and-bipolar-disorder-neuropsychologically-distinct-a-meta-analysis-of-comparative-studies
#17
C Samamé, A G Szmulewicz, M P Valerio, D J Martino, S A Strejilevich
BACKGROUND: Neuropsychological deficits are present in both major depression and bipolar disorder. So far, however, reports directly comparing these mood disorders with regard to cognitive outcomes have been scant and yielded inconsistent results. This work aims to combine the findings of comparative studies of cognition in major depression and bipolar disorder in order to explore whether these neuropsychiatric conditions present with distinct cognitive features. METHODS: The main online databases were extensively searched to retrieve reports assessing neurocognitive functioning in two groups of mood disorder patients, one with major depressive disorder and another with bipolar disorder, both in the same phase of illness...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810613/use-of-atomoxetine-and-suicidal-ideation-in-children-and-adolescents-results-of-an-observational-cohort-study-within-general-practice-in-england
#18
M Davies, A Coughtrie, D Layton, S A S Shakir
AIM: To investigate the association between atomoxetine, a drug used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), and suicidal ideation, within a cohort of 2-18-year-old patients in England. METHODS: The study was conducted using the observational cohort technique of Modified prescription event monitoring (M-PEM). Patients prescribed atomoxetine were identified from dispensed prescriptions issued by primary care physicians. A customised postal GP questionnaire was used to capture outcome data for suicidal ideation...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27810612/inflammatory-cardio-metabolic-and-diabetic-profiling-of-chronic-schizophrenia
#19
R Balõtšev, K Koido, V Vasar, S Janno, K Kriisa, R Mahlapuu, U Ljubajev, M Parksepp, P Veiksaar, V Volke, A Lang, L Haring, M Zilmer, E Vasar
BACKGROUND: There is a growing interest in low-grade inflammatory and metabolic alterations in patients with chronic schizophrenia (SCH). METHODS: Inflammatory (tumor-necrosis factor-α [TNF-α], interferon-γ [IFN-γ], interleukins [IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10], monocyte chemo-attractant protein-1 [MCP-1]) and growth factors (vascular endothelial growth factor [VEGF], epidermal growth factor [EGF]) were measured in blood serum samples of 105 SCH patients and 148 control subjects (CS)...
October 28, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27668551/association-of-the-brain-derived-neurotrophic-factor-val66met-polymorphism-with-negative-symptoms-severity-but-not-cognitive-function-in-first-episode-schizophrenia-spectrum-disorders
#20
G Mezquida, R Penadés, B Cabrera, G Savulich, A Lobo, A González-Pinto, M J Penzol, I Corripio, E Fernandez-Egea, P Gassó, M J Cuesta, M Bernardo
OBJECTIVE: A functional polymorphism of the brain-derived neurotrophic factor gene (BDNF) Val66Met has been associated with cognitive function and symptom severity in patients with schizophrenia. It has been suggested that the Val66Met polymorphism has a role as a modulator in a range of clinical features of the illness, including symptoms severity, therapeutic responsiveness, age of onset, brain morphology and cognitive function. However, little work has been done in first-episode schizophrenia (FES) spectrum disorders...
October 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
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