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International Journal of Hematology

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https://www.readbyqxmd.com/read/30008114/the-better-outcomes-of-diffuse-large-b-cell-lymphoma-in-adolescents-and-young-adults
#1
LETTER
Junnan Wang, Fengshang Yan, Yiran Wang
No abstract text is available yet for this article.
July 14, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/30006733/molecular-characterization-of-hb-h-disease-in-southern-thailand
#2
Kesara Nittayaboon, Chamnong Nopparatana
Genotypes of 260 individuals with hemoglobin H (Hb H) disease originating from various provinces in southern Thailand were characterized by multiplex PCR (M-PCR) and reverse dot blot hybridization (RDB). M-PCR was used to amplify target fragments and then hybridized with allele-specific oligonucleotide (ASO) probes which were bound on a nylon membrane. A total of eight α-thalassemia (α-thal) mutations, which produced eight Hb H disease genotypes (α0 -thal/α+ -thal), were detected. The most common form of α0 -thal was -SEA with a frequency of 99...
July 13, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29987745/early-prefibrotic-primary-myelofibrosis-in-patients-who-were-initially-diagnosed-with-essential-thrombocythemia
#3
Ayako Kamiunten, Kotaro Shide, Takuro Kameda, Masafumi Ito, Masaaki Sekine, Yoko Kubuki, Tomonori Hidaka, Keiichi Akizuki, Yuki Tahira, Takanori Toyama, Noriaki Kawano, Kousuke Marutsuka, Kouichi Maeda, Masanori Takeuchi, Hiroshi Kawano, Seiichi Sato, Junzo Ishizaki, Haruko Shimoda, Kiyoshi Yamashita, Hitoshi Matsuoka, Kazuya Shimoda
A new entity, namely early/prefibrotic primary myelofibrosis (PMF), was introduced as a subtype of PMF in the 2016 revised World Health Organization (WHO) criteria for myeloproliferative neoplasms (MPN). It was diagnosed based on histopathological features of bone marrow (BM) biopsy specimens together with clinical parameters [leukocytosis, anemia, elevated lactate dehydrogenase (LDH) values, and splenomegaly]. The aim of this study was to evaluate the prevalence of early/prefibrotic PMF in patients who were previously diagnosed with ET, and to compare clinical features at diagnosis and outcomes between early/prefibrotic PMF and essential thrombocythemia (ET) patients...
July 9, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29987744/invasive-scopulariopsis-alboflavescens-infection-in-patient-with-acute-myeloid-leukemia
#4
Keiji Kurata, Sho Nishimura, Hiroya Ichikawa, Rina Sakai, Yu Mizutani, Kei Takenaka, Seiji Kakiuchi, Yoshiharu Miyata, Akihito Kitao, Kimikazu Yakushijin, Shinichiro Kawamoto, Katsuya Yamamoto, Mitsuhiro Ito, Hiroshi Matsuoka, Issei Tokimatsu, Katsuhiko Kamei, Hironobu Minami
Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal...
July 9, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29980910/correction-to-effects-of-eculizumab-treatment-on-quality-of-life-in-patients-with-paroxysmal-nocturnal-hemoglobinuria-in-japan
#5
Yasutaka Ueda, Naoshi Obara, Yuji Yonemura, Hideyoshi Noji, Masayoshi Masuko, Yoshinobu Seki, Katsuya Wada, Takahisa Matsuda, Hirozumi Akiyama, Takayuki Ikezoe, Shigeru Chiba, Yoshinobu Kanda, Tatsuya Kawaguchi, Tsutomu Shichishima, Hideki Nakakuma, Shinichiro Okamoto, Jun-Ichi Nishimura, Yuzuru Kanakura, Haruhiko Ninomiya
In the original publication of this article, Tables 2, 3 and 4 were published incorrectly. The corrected tables 2, 3 and 4 are given in the following pages.
July 6, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29978433/immuno-suppressive-function-of-nucleus-transducible-baf57-%C3%AE-ph-in-t-cell-activation-via-degradation-of-endogenous-baf57
#6
Jae-Seung Moon, Hong-Jai Lee, Chun-Chang Ho, Jin-Su Shin, Sankar Ghosh, Jung-Ho Kim, Sang-Kyou Lee
The BAF57 subunit, an indispensable member of the BAF complex, is functionally implicated in apoptosis, cell cycle, and T cell development through chromosomal remodeling. However, the precise roles of BAF57 in the T cell receptor (TcR)-mediated signaling pathway have not been elucidated. In this study, a nucleus-transducible form of BAF57, absent the proline-rich and HMG domains (ntBAF57-ΔPH), was generated to interfere with the interaction between BAF57 and its binding protein, BAF155. ntBAF57-ΔPH was effectively delivered into mouse CD4+ T cells in a dose- and time-dependent manner, without cellular toxicity...
July 5, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29978432/quantification-of-bone-marrow-plasma-cell-levels-using-various-international-myeloma-working-group-response-criteria-in-patients-with-multiple-myeloma
#7
Kentaro Narita, Hiroki Kobayashi, Yoshiaki Abe, Hiroaki Kitadate, Masami Takeuchi, Kosei Matsue
We examined the association of residual bone-marrow plasma cells (PCs) and International Myeloma Working Group (IMWG) response assessment in light-chain-only multiple myeloma (LCMM) and intact immunoglobulin multiple myeloma (IIMM) using multicolour flow cytometry (MFC). We identify considerable differences in bone-marrow neoplastic PC levels between IIMM and LCMM for the same IMWG response categories. Furthermore, even in the same IMWG response category, residual neoplastic PC levels differed considerably over a logarithmic scale range However, normalization of the free light-chain ratio is associated with deeper response (< 10-4 ) in LCMM, but not in IIMM...
July 5, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29971603/re-re-dabigatran-overdose-a-case-report-of-acute-hepatitis-extracorporeal-treatment-and-review-of-the-literature
#8
LETTER
Mariagrazia Porru, Antonella Mameli, Maria Elisabetta Cianchetti, Filomena Ruberto, Mario Musu, Doris Barcellona, Francesco Marongiu
No abstract text is available yet for this article.
July 3, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29971602/clinical-characteristics-of-pediatric-patients-with-myeloid-sarcoma-without-bone-marrow-involvement-in-japan
#9
Takashi Taga, Toshihiko Imamura, Kentaro Nakashima, Naoko Maeda, Akihiro Watanabe, Yuji Miyajima, Sachi Sakaguchi, Hitoshi Sano, Daiichiro Hasegawa, Hirohide Kawasaki, Souichi Adachi, Masatoshi Takagi, Katsuyoshi Koh, Atsushi Manabe, Tomohiko Taki, Yasushi Ishida
Myeloid sarcoma (MS) is a rare neoplastic condition that is often described in association with acute myeloid leukemia (AML). MS in childhood has received little attention, particularly in Japan. We carried out a nationwide retrospective analysis of Japanese children diagnosed with MS without bone marrow involvement. Inclusion criteria were diagnosis of MS at younger than 20 years of age between January 1, 2000 and December 31, 2013. There was a predominance of males (8:2), and the median age at MS diagnosis was 4 years...
July 3, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29967977/correction-to-atypical-erythroblastosis-in-a-patient-with-diamond-blackfan-anemia-who-developed-del-20q-myelodysplasia
#10
Motoshi Sonoda, Masataka Ishimura, Yuko Ichimiya, Eiko Terashi, Katsuhide Eguchi, Yasunari Sakai, Hidetoshi Takada, Asahito Hama, Hitoshi Kanno, Tsutomu Toki, Etsuro Ito, Shouichi Ohga
The corresponding author should be ''Masataka Ishimura'', and not ''Motoshi Sonoda'' as given in the original publication of the article.
July 2, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29959747/extracorporeal-photopheresis-with-tc-v-in-japanese-patients-with-steroid-resistant-chronic-graft-versus-host-disease
#11
Shinichiro Okamoto, Takanori Teshima, Mizuha Kosugi-Kanaya, Kaoru Kahata, Naomi Kawashima, Jun Kato, Takehiko Mori, Yukiyasu Ozawa, Koichi Miyamura
There are few established therapies for chronic graft-versus-host disease (cGVHD) refractory to first-line treatment with steroids. We evaluated the efficacy and safety of extracorporeal photopheresis (ECP) with a third-generation TC-V device in Japanese patients with cGVHD. Fifteen patients with steroid-resistant or -intolerant cGVHD after allogeneic hematopoietic stem cell transplantation participated in this multicenter open-label study. Extracorporeal photopheresis was conducted on days 1-3, week 1; days 1-2, weeks 2-12; and days 1-2, weeks 16, 20, and 24...
June 29, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29959746/circulating-tumor-dna-dynamically-predicts-response-and-or-relapse-in-patients-with-hematological-malignancies
#12
Sousuke Nakamura, Kazuaki Yokoyama, Nozomi Yusa, Miho Ogawa, Tomomi Takei, Asako Kobayashi, Mika Ito, Eigo Shimizu, Rika Kasajima, Yuka Wada, Rui Yamaguchi, Seiya Imoto, Tokiko Nagamura-Inoue, Satoru Miyano, Arinobu Tojo
A growing body of evidence suggests that tumor-derived fragmentary DNA, known as circulating tumor DNA (ctDNA), has the potential to serve as a non-invasive biomarker for disease monitoring. However, in the setting of hematological malignancy, few published studies support the utility of ctDNA. We retrospectively investigated ctDNA levels of 17 patients with various hematological malignancies who had achieved remission after first-line therapy. We identified somatic driver mutations by next-generation sequencing, and designed droplet digital PCR assays for each mutation to measure ctDNA...
June 29, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29959745/obstetric-outcomes-and-acceptance-of-alternative-therapies-to-blood-transfusion-by-jehovah-s-witnesses-in-japan-a-single-center-study
#13
Mie Tanaka, Shinya Matsuzaki, Masayuki Endo, Aiko Kakigano, Kazuya Mimura, Tsuyoshi Takiuchi, Tatsuya Miyake, Takuji Tomimatsu, Yutaka Ueda, Tadashi Kimura
We sought to investigate obstetric outcomes and acceptance rates for blood products or types of autotransfusion by Jehovah's Witnesses (JWs) at a single institution in Japan. We retrospectively reviewed cases of 84 pregnant JW patients and 95 deliveries from April 2001 to August 2017. We examined the acceptance rates of blood transfusions, blood products, and autotransfusion types in patients who experienced postpartum hemorrhage (PPH), and investigated estimated hemorrhage volume at delivery and PPH treatments...
June 29, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29956082/targeting-transcription-factors-in-acute-myeloid-leukemia
#14
REVIEW
Hisashi Takei, Susumu S Kobayashi
Transcription factors recognize and bind to consensus sequence elements that are specific for each transcription factor, and the transcription factors then regulate downstream gene expression. In the bone marrow, transcription factors, such as C/EBPα, PU.1, and RUNX1, control essential genes to maintain the normal hematopoietic system. Dysregulation of transcription factors caused by gene mutations, chromosomal aberrations, or aberrant expression can lead to cancer, including acute myeloid leukemia. In the past, transcription factors were not considered "druggable" targets...
June 28, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29951735/re-induction-chemotherapy-using-flag-mitoxantrone-for-adult-patients-with-relapsed-acute-leukemia-a-single-center-experience-from-united-arab-emirates
#15
Inaam Bashir Hassan, Jorgen Kristensen, Khalid Al Qawasmeh, Arif Alam
We studied the outcome of 47 adult patients with relapsed acute leukaemia (AML = 25 and ALL = 22) treated with FLAG-mitoxantrone regimen. Median time to relapse was 10.7 months (range 1.9-27.7). Complete remission (CR2) was 60.1% which was significantly more frequent in ALL compared to AML (P = 0.049). WBC count < 100 × 109 /L at initial diagnosis and time to relapse > 1 year were significantly predictor for CR2 in AML (P = 0.005 for both). Induction death was significantly higher in ALL compared to AML (P = 0...
June 27, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29946854/successful-treatment-of-cytarabine-related-neurotoxicity-with-corticosteroids-a-case-series
#16
Jennifer L Dotson, Muhammad Omer Jamil
Neurotoxicity from high-dose cytarabine, a pyrimidine metabolite used in treatment for acute myeloid leukemia, is a known but dose-limiting toxicity which has incidences in up to 14% in patients receiving high doses of the drug. Neurologic symptoms vary but range from somnolence and ataxia to more severe complications such as seizures and even death. There are no validated treatments other than discontinuation of the drug and supportive measures. We present two cases of cytarabine-related neurotoxicity treated with corticosteroids with complete resolution of symptoms...
June 26, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29936674/whole-exome-analysis-to-detect-congenital-hemolytic-anemia-mimicking-congenital-dyserythropoietic-anemia
#17
Motoharu Hamada, Sayoko Doisaki, Yusuke Okuno, Hideki Muramatsu, Asahito Hama, Nozomu Kawashima, Atsushi Narita, Nobuhiro Nishio, Kenichi Yoshida, Hitoshi Kanno, Atsushi Manabe, Takashi Taga, Yoshiyuki Takahashi, Satoru Miyano, Seishi Ogawa, Seiji Kojima
Congenital dyserythropoietic anemia (CDA) is a heterogeneous group of rare congenital disorders characterized by ineffective erythropoiesis and dysplastic changes in erythroblasts. Diagnosis of CDA is based primarily on the morphology of bone marrow erythroblasts; however, genetic tests have recently become more important. Here, we performed genetic analysis of 10 Japanese patients who had been diagnosed with CDA based on laboratory findings and morphological characteristics. We examined 10 CDA patients via central review of bone marrow morphology and genetic analysis for congenital bone marrow failure syndromes...
June 23, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29931624/a-unique-clinical-presentation-of-de-novo-acute-promyelocytic-leukemia-as-a-myeloid-sarcoma-of-the-breast
#18
Iveta Oravcova, Eva Mikuskova, Michaela Leitnerova, Jan Gyarfas, Andrea Mlcakova, Peter Szepe, Lukas Plank, Ludmila Demitrovicova, Vanda Mikudova, Silvia Cingelova, Michal Mego, Lubos Drgona
Myeloid sarcoma is a rare presentation of acute leukemia as a solid tumor at various extramedullary sites. It may present concurrently, before or after the onset of systemic bone marrow leukemia. Unusual clinical localization may lead to misdiagnosis, or delayed diagnosis and treatment. We describe the first case, to our knowledge, of de novo myeloid sarcoma of the breast confirmed as acute promyelocytic leukemia. Immunohistochemical analysis, flow cytometry, fluorescent in situ hybridization analysis and molecular analysis using RQ-PCR of tissue samples should be routine in determining the correct diagnosis in this setting...
June 21, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29926359/breakthrough-infection-of-geotrichum-capitatum-during-empirical-caspofungin-therapy-after-umbilical-cord-blood-transplantation
#19
Shuki Oya, Tsuyoshi Muta
We experienced a breakthrough fungal infection caused by Geotrichum capitatum during empirical therapy with caspofungin. A 68-year-old male patient with refractory acute lymphoblastic leukemia had received umbilical cord blood transplantation after two courses of induction therapy. Empirical therapy with caspofungin was initiated 5 days before transplantation. Tacrolimus was continuously infused to prevent graft-versus-host disease. A minidose of methotrexate was intravenously administered on days 1 and 3 post-transplantation, which was changed to prednisolone from day 7 due to severe mucositis...
June 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29923124/severe-acyclovir-resistant-herpes-simplex-virus-1-infection-following-cord-blood-transplantation
#20
LETTER
Tomonari Shigemura, Yozo Nakazawa, Tomoki Yoshikawa, Hikaru Fujii, Souichi Yamada, Masayuki Saijo, Ryuhei Okuyama
No abstract text is available yet for this article.
June 19, 2018: International Journal of Hematology
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