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International Journal of Hematology

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https://www.readbyqxmd.com/read/28921451/distribution-of-malignant-lymphomas-in-the-anterior-mediastinum-a-single-institution-study-of-76-cases-in-japan-1997-2016
#1
Akiko Miyagi Maeshima, Hirokazu Taniguchi, Tomotaka Suzuki, Sayako Yuda, Kosuke Toyoda, Nobuhiko Yamauchi, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Yukio Kobayashi, Kensei Tobinai
We analyzed the distribution of tumors and lymphomas of the anterior mediastinum diagnosed between 1997 and 2016 at the National Cancer Center Hospital, Japan. The median age of 283 patients with anterior mediastinal tumors was 48 (range 6-84) years, and 143 (51%) were male. The incidence of tumors was as follows: thymoma, 34%; thymic carcinoma, 16%; primary mediastinal large B-cell lymphoma (PMBL), 13%; germ cell tumors, 10%; classical Hodgkin lymphoma (CHL), 9%; thymic cyst, 7%; metastatic tumors, 3%; T lymphoblastic leukemia/lymphoma (T-LBL), 2%; other lymphomas, 3%; and others, 3%...
September 18, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28905323/phase-i-study-of-panobinostat-and-5-azacitidine-in-japanese-patients-with-myelodysplastic-syndrome-or-chronic-myelomonocytic-leukemia
#2
Yukio Kobayashi, Wataru Munakata, Michinori Ogura, Toshiki Uchida, Masafumi Taniwaki, Tsutomu Kobayashi, Fumika Shimada, Masataka Yonemura, Fumiko Matsuoka, Takeshi Tajima, Kimikazu Yakushijin, Hironobu Minami
The current therapy for high-risk myelodysplastic syndrome (MDS) involves repeated cycles of the DNA demethylating agent 5-azacitidine (5-Aza), but combination treatments have been proposed to improve patient outcomes. We performed a phase Ib study to investigate the safety and tolerability of 5-Aza (75 mg/m(2)) combined with the histone deacetylase inhibitor panobinostat (PAN) in adult Japanese patients with MDS or chronic myelomonocytic leukemia (CMML). Eleven patients were enrolled; five received 20 mg PAN + 5-Aza and six received 30 mg PAN + 5-Aza...
September 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28900860/modified-immunosuppressive-therapy-with-porcine-antilymphocyte-globulin-plus-delayed-cyclosporine-a-in-children-with-severe-aplastic-anemia
#3
Qingya Cui, Pingping Sha, Haifei Chen, Hongshi Shen, Longmei Qin, Zhengyang Li, Tianqin Wu, Zhaoyue Wang
Immunosuppressive therapy (IST) with antithymocyte globulin (ATG) and cyclosporine (CsA) is the standard treatment for children with severe aplastic anemia (SAA) with no human leukocyte antigen-matched siblings. Due to the unavailability of horse ATG in China, porcine antilymphocyte globulin (p-ALG), which is less expensive and more effective than rabbit ATG, is widely used. We sought to evaluate the efficacy and safety profile of modified IST with p-ALG plus delayed CsA at day 21 in 50 SAA children. Eighteen SAA patients who progressed from nonsevere aplastic anemia (NSAA) were classified as SAA-II; the other 32 patients were classified as SAA-I...
September 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28900852/the-infiltration-of-classical-hodgkin-lymphoma-cells-into-pleural-effusion
#4
LETTER
Momoko Kito, Wataru Munakata, Kouji Ono, Akiko Miyagi Maeshima, Hiromichi Matsushita
No abstract text is available yet for this article.
September 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28900847/effect-of-rituximab-on-primary-central-nervous-system-lymphoma-a-meta-analysis
#5
REVIEW
Yue Song, Yibo Wen, Weili Xue, Yanjie Zhang, Mingzhi Zhang
The effect of rituximab on primary central nervous system lymphoma (PCNSL) is controversial. We performed this meta-analysis to assess the efficacy of treatment with or without rituximab for PCNSL. We first conducted a search for qualified studies using PubMed, the Cochrane Library, and the Web of Science. The meta-analysis was conducted to compare odds ratios (ORs) with the corresponding 95% confidence interval (95% CI) for complete remission (CR) rate, progression-free survival (PFS), and overall survival (OS) using Review Manager 5...
September 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28895035/splenectomy-vs-rituximab-as-a-second-line-therapy-in-immune-thrombocytopenic-purpura-a-single-center-experience
#6
Ahmed S Al Askar, Naila A Shaheen, Mohsen Al Zahrani, Mohammed G Al Otaibi, Bader S Al Qahtani, Faris Ahmed, Mohand Al Zughaibi, Ismat Kamran, May Anne Mendoza, Altaf Khan
Immune thrombocytopenic purpura (ITP) is a common hematological disease treated primarily by corticosteroids. The aim of the present study was to compare response rate between patients, underwent splenectomy vs. rituximab as second-line therapy. Adult patients diagnosed with ITP who did not respond to corticosteroids or relapsed during the period 1990-2014 were included in a quasi-experimental study. Categorical variables were compared using Fisher exact test. Response to treatment was compared using logistic regression...
September 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28884443/megakaryoblastic-transformation-of-therapy-related-myeloid-neoplasms-with-concomitant-myc-amplification-on-double-minute-chromosomes
#7
LETTER
Katsuya Yamamoto, Kimikazu Yakushijin, Yumiko Inui, Shinichiro Kawamoto, Kazuyoshi Kajimoto, Yoshitake Hayashi, Hiroshi Matsuoka, Hironobu Minami
No abstract text is available yet for this article.
September 7, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28879630/polymorphism-in-ikzf1-gene-affects-clinical-outcome-in-diffuse-large-b-cell-lymphoma
#8
Marta Bielska, Maciej Borowiec, Dorota Jesionek-Kupnicka, Marcin Braun, Marcin Bojo, Agata Pastorczak, Ewa Kalinka-Warzocha, Monika Prochorec-Sobieszek, Tadeusz Robak, Krzysztof Warzocha, Wojciech Młynarski, Ewa Lech-Marańda
IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 polymorphism between DLBCL patients and controls. However, the 2-year PFS rate of patients with the IKZF1 TT genotype was 54.3% compared to 68.6% in those with the IKZF1 G+ genotypes. Moreover, the IKZF1 rs4132601 polymorphism retained its independent prognostic impact on PFS...
September 6, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28879549/decreased-platelet-count-in-children-with-epilepsy-treated-with-valproate-and-its-relationship-to-the-immature-platelet-fraction
#9
Hirokazu Kurahashi, Akiyoshi Takami, Kenta Murotani, Shingo Numoto, Akihisa Okumura
This study examined relationships between valproate (VPA) and platelet count and immature platelet fraction (IPF). We compared the platelet count and IPF among three groups of children: those treated with VPA, those treated with other antiepileptic drugs (AEDs), and a reference group. IPF was measured using flow cytometry, and absolute immature platelet count (A-IPC) was calculated. The platelet count was significantly lower in the VPA group than in other AED and reference groups. In all groups, IPF was negatively correlated with platelet count...
September 6, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28864871/eltrombopag-for-thrombocytopenia-in-patients-with-advanced-solid-tumors-receiving-gemcitabine-based-chemotherapy-a-randomized-placebo-controlled-phase-2-study
#10
Eric S Winer, Howard Safran, Boguslawa Karaszewska, Sebastian Bauer, Dilawar Khan, Steffen Doerfel, Paul Burgess, Stacey Kalambakas, Yasser Mostafa Kamel, Frederic Forget
In this phase 2 study, patients with solid tumors receiving gemcitabine monotherapy or gemcitabine plus cisplatin/carboplatin were randomized 2:1 to eltrombopag 100 mg (n = 52) or placebo (n = 23) for 5 days before and after chemotherapy was started. The primary endpoint was prechemotherapy (Day 1) platelet count across ≤6 cycles. Prechemotherapy platelet counts were numerically higher with eltrombopag than placebo. Frequencies of grades 3/4 thrombocytopenia were lower with eltrombopag in both the combination therapy (77 vs...
September 1, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28856623/jsh-guideline-for-tumors-of-hematopoietic-and-lymphoid-tissues-leukemia-2-acute-promyelocytic-leukemia-apl
#11
Norio Asou, Hiroyuki Fujita, Katsuji Shinagawa
No abstract text is available yet for this article.
August 30, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28856590/autologous-hematopoietic-stem-cell-transplantation-may-improve-long-term-outcomes-in-patients-with-newly-diagnosed-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-retrospective-controlled-study-in-a-single-center
#12
Jingwen Wang, Liqiang Wei, Jin Ye, Lei Yang, Xin Li, Jia Cong, Na Yao, Xueying Cui, Yiping Wu, Jing Ding, Le Zhang
Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare disease with a poor prognosis. The long-term effect of autologous hematopoietic stem cell transplantation (auto-HSCT) on ENKTL has been reported occasionally but needs further investigation. In this retrospective study from a single center, 20 ENKTL patients who received induction chemotherapy followed by auto-HSCT ± involved-field radiotherapy (IFRT) ± additional chemotherapy were enrolled as a study group. Another 60 fit ENKTL patients who received induction chemotherapy ± IFRT ± additional chemotherapy were selected as the control group...
August 30, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28849374/toxicological-effects-of-fludarabine-and-treosulfan-conditioning-before-allogeneic-stem-cell-transplantation
#13
Mats Remberger, Johan Törlen, Ibrahim El Serafi, Karin Garming-Legert, Andreas Björklund, Per Ljungman, Mikael Sundin, Moustapha Hassan, Jonas Mattsson
We studied early potential treosulfan-related toxicity in 118 patients treated with treosulfan-based conditioning before allogeneic hematopoietic stem-cell transplantation. Most patients (n = 93) had a hematological malignancy. In 80 cases, a HLA-A, -B and -DR matched unrelated donor was used, while 33 patients had a HLA-identical sibling donor, and five received an HLA-A, -B or -DR allele mismatched, unrelated donor. Levels of AST, ALT, and bilirubin were significantly increased 1 week after HSCT compared to before HSCT...
August 28, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28849369/recent-trends-in-practice-patterns-and-comparisons-between-immunoglobulin-and-corticosteroid-in-pediatric-immune-thrombocytopenia
#14
Yusuke Okubo, Nobuaki Michihata, Naho Morisaki, Mayumi Hangai, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
The clinical benefits and practice patterns of different pharmacologic regimes in acute pediatric immune thrombocytopenia (ITP) remain unclear in Japan. Using a national inpatient database, we analyzed recent trends in practice patterns for acute pediatric ITP, and compared risks of 6-month readmission, total hospitalization costs, and lengths of hospital stay between ITP children treated with intravenous immunoglobulin (IVIG) and corticosteroid, using inverse probability weighting analyses. From 2010 to 2014, the proportions of IVIG use increased from 43...
August 28, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28831750/imbalanced-expression-of-polycistronic-mirna-in-acute-myeloid-leukemia
#15
Ryutaro Kotaki, Hiroshi Higuchi, Daisuke Ogiya, Yasuhiro Katahira, Natsumi Kurosaki, Naoko Yukihira, Jun Ogata, Haruna Yamamoto, Syakira Mohamad Alba, Azran Azhim, Tatsuo Kitajima, Shigeaki Inoue, Kazuhiro Morishita, Koh Ono, Ryo Koyama-Nasu, Ai Kotani
miR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is positively regulated by ecotropic virus integration site-1 (EVI1). Previously, we described how miR-133 has anti-tumorigenic potential through repression of EVI1 expression. It has also been reported that miR-1 is oncogenic in the case of acute myeloid leukemia (AML). Here, we show that expression of miR-1 and miR-133, which have distinct functions, is differentially regulated between AML cell lines...
August 22, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28825215/risk-factors-in-patients-undergoing-haploidentical-hematopoietic-stem-cell-transplantation-for-high-risk-childhood-acute-leukemia
#16
Dong-Mei Han, Xiao-Li Zheng, Li Ding, Hong-Min Yan, Zhi-Dong Wang, Mei Xue, Ling Zhu, Jing Liu, Heng-Xiang Wang
In the present study, we sought to analyze the risk factors following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in children with high-risk acute leukemia. We retrospectively reviewed data from 73 children with high-risk leukemia. Univariate and multivariate analyses were performed to evaluate relationships between variables and patient outcomes. The mean time for neutrophil engraftment was significantly shorter in children given a graft with a higher number of nucleated cells (>10...
August 20, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28825207/infectious-complications-in-multiple-myeloma-receiving-autologous-stem-cell-transplantation-in-the-past-10%C3%A2-years
#17
Hyunkyung Park, Jeonghwan Youk, Hak Ro Kim, Youngil Koh, Ji Hyun Kwon, Sung-Soo Yoon, Seonyang Park, Pyoeng Gyun Choe, Nam Joong Kim, Myoung-Don Oh, Wan Beom Park, Inho Kim
Infection is one of the main causes of early-treatment mortality in multiple myeloma (MM) patients during autologous stem cell transplantation (autoSCT). In the present study, we sought to determine the incidence of, and risk factors for, infection during hospital stays after autoSCT. We retrospectively evaluated 324 autoSCT events that occurred in 285 MM patients between 2006 and 2015, and reviewed the clinical characteristics of patients and history of infections. Sixty-eight infection events occurred, including bacteremia (24), other bacterial infections (7), as well as infections caused by Cytomegalovirus (17), Herpes simplex virus (12), Varicella zoster virus (3), Aspergillus (3) and Pneumocystis jiroveci (2)...
August 20, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28815419/effect-of-sertraline-on-complications-and-survival-after-hematopoietic-stem-cell-transplantation-a-double-blind-placebo-controlled-clinical-study
#18
Maria Tavakoli-Ardakani, Raziyeh Kheshti, Mehrpooya Maryam
Previous studies have found a connection between psychiatric problems and post-hematopoietic stem-cell transplantation (HSCT) complications. We sought to evaluate the effect of sertraline on engraftment time, hospitalization period, mortality, and post-transplantation complications in HSCT recipients with depression and/or anxiety. We recruited adults aged 18-60, who were candidates for autologous or allogeneic HSCT with major depression and/or anxiety disorder. They were administered 50 mg of sertraline or placebo daily for the first week, and then 100 mg for the following seven weeks...
August 16, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28815418/availability-of-angiography-and-therapeutic-embolization-for-the-treatment-of-acute-bleeding-in-patients-with-hemophilia
#19
Mi Jin Kim, Ji Young Oh, Young Shil Park
Clotting factor replacement therapy alone is often inadequate for acute bleeding in hemophilia patients, and surgery for such patients poses significant clinical challenges. Arterial angiographic intervention is used to control bleeding in local blood vessels. In the present study, we examined the clinical course and prognosis of hemophilia patients with bleeding who had undergone angiography, and evaluated the validity of diagnostic angiography and therapeutic embolization in these patients. Angiography was performed in five hemophilia patients, who experienced bleeding that was difficult to control even after treatment with clotting factor replacement or bypassing agent therapy...
August 16, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28815410/efficacy-and-safety-of-a-4-factor-prothrombin-complex-concentrate-for-rapid-vitamin-k-antagonist-reversal-in-japanese-patients-presenting-with-major-bleeding-or-requiring-urgent-surgical-or-invasive-procedures-a-prospective-open-label-single-arm-phase-3b-study
#20
Shigeki Kushimoto, Toshio Fukuoka, Akio Kimura, Kazunori Toyoda, Andres Brainsky, Amy Harman, Thomas Chung, Masahiro Yasaka
Rapid vitamin K antagonist (VKA) reversal is required in patients experiencing major bleeding or requiring urgent surgery. Four-factor prothrombin complex concentrate (4F-PCC; Beriplex(®)/Kcentra(®)) was shown in two large randomized controlled, international phase 3b trials to be an effective alternative to plasma for urgent VKA reversal. In the present prospective, open-label, single-arm phase 3b trial, we evaluate the efficacy and safety of 4F-PCC in Japanese patients. Eleven patients [international normalized ratio (INR) ≥2] requiring rapid VKA reversal owing to major bleeding (n = 6) or before urgent surgical/invasive procedures (n = 5) were administered 4F-PCC dosed based on INR and weight...
August 16, 2017: International Journal of Hematology
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