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International Journal of Hematology

Tomoko Kimura, Takahiro Kuragano, Kiyoko Yamamoto, Masayoshi Nanami, Yukiko Hasuike, Takeshi Nakanishi
Although the primary cause of anemia in chronic kidney disease (CKD) is lack of sufficient erythropoietin (EPO), other factors may be involved, including the deregulation of iron metabolism. To clarify the mechanism of deranged erythropoiesis in CKD, we evaluated bone marrow (BM) cells in adenine-induced CKD mice. They showed even higher EPO expression in the kidney. Hepatic hepcidin mRNA and plasma hepcidin and ferritin levels were increased. Flow cytometry revealed a decrease in the number of cells expressing transferrin receptor (TfR), or late erythroid progenitors in BM; these cells correspond to proerythroblasts, and basophilic and polychromatic erythroblasts...
September 19, 2018: International Journal of Hematology
Kyoko Ito, Massimo Bonora, Keisuke Ito
HSCs have a fate choice when they divide; they can self-renew, producing new HSCs, or produce daughter cells that will mature to become committed cells. Technical challenges, however, have long obscured the mechanics of these choices. Advances in flow-sorting have made possible the purification of HSC populations, but available HSC-enriched fractions still include substantial heterogeneity, and single HSCs have proven extremely difficult to track and observe. Advances in single-cell approaches, however, have led to the identification of a highly purified population of hematopoietic stem cells (HSCs) that make a critical contribution to hematopoietic homeostasis through a preference for self-renewing division...
September 15, 2018: International Journal of Hematology
Jew Win Kuan, Anselm Ting Su, Chooi Fun Leong, Motomi Osato, Goro Sashida
BACKGROUND: Studies of a provisional entity pre-clinical chronic myeloid leukaemia (CML), which precedes chronic phase (CP) without leucocytosis or blood/marrow feature of CML CP, has been increasing. OBJECTIVE: To perform a systematic review of pre-clinical CML and analysis the data relevant to disease progression to CML CP. METHOD: We performed a literature search on 16 July 2017 using EBSCOhost Research Databases interface and Western Pacific Region Index Medicus...
September 14, 2018: International Journal of Hematology
Norifumi Tsukamoto, Akihiko Yokohama, Tetsuya Higuchi, Takeki Mitsui, Hiromi Koiso, Makiko Takizawa, Hiroaki Shimizu, Takuma Ishizaki, Morio Matsumoto, Kohtaro Toyama, Tohru Sakura, Hidemi Ogura, Takayuki Saitoh, Fumihiro Ishida, Hirokazu Murakami, Yoshito Tsushima, Hiroshi Handa
90Y-ibritumomab tiuxetan (90Y-IT) is widely used, but the factors responsible for its optimal treatment effects are unknown. We enrolled 34 patients with relapsed indolent lymphoma treated with 90Y-IT monotherapy at Gunma University Hospital between 2003 and 2014 in the present study. Clinical data including computed tomography and 18-Fluoro-deoxyglucose positron emission tomography were retrospectively analyzed. The overall response rate and complete response rate were 91% and 82%, respectively. The median progression-free survival (PFS) and overall survival were 32 months and not reached, respectively...
September 10, 2018: International Journal of Hematology
Yoshiaki Abe, Yoshiaki Usui, Kentaro Narita, Masami Takeuchi, Kosei Matsue
We describe a patient who presented with large cardiac diffuse large B-cell lymphoma (DLBCL) and adrenal masses. The patient also had subcutaneous intravascular lymphoma lesions which were detected by random skin biopsy. Although ambiguous, minimal extravascular location of lymphoma cells is permitted for the diagnosis of intravascular large B-cell lymphoma (IVLBCL) in the WHO definition, a number of rare cases have been reported as having concomitant tumours in other organs, such as the adrenal gland, brain, and penis...
September 8, 2018: International Journal of Hematology
Katsuya Ikuta, Hiroaki Ito, Keiji Takahashi, Shinya Masaki, Masaru Terauchi, Yasuo Suzuki
Iron-deficiency anemia (IDA) accounts for majority of anemia. Although iron replacement therapy is effective, in Japan, conventional iron formulations have disadvantages such as gastrointestinal side effects for oral formulations and issues of frequent administration for intravenous (IV) formulations. Ferric carboxymaltose (FCM), which overcomes these limitations, is widely used as an IV iron source overseas. In this multi-center, open-label, single-arm study, we investigated the safety and efficacy of FCM up to 12 weeks after the start of administration in patients with IDA caused by digestive diseases...
September 7, 2018: International Journal of Hematology
Shoji Saito, Yoshifumi Ogiso, Kazuo Sakashita
No abstract text is available yet for this article.
September 6, 2018: International Journal of Hematology
Hiroyuki Morita, Akihito Matsuoka, Jun-Ichiro Kida, Hiroyuki Tabata, Kaoru Tohyama, Yumi Tohyama
A microtubule-associated motor protein, kinesin-like family member 20A (KIF20A; also called MKlp2) is required for cytokinesis and contributes to intracellular vesicular trafficking. KIF20A plays a critical role in the development of several cancers, but its role in blood cells and hematological malignancies have not been studied. In the present study, we focused on the role of KIF20A in hematopoietic cells and possible involvement in myeloid neoplasms. We found that human leukemia cell lines and normal bone marrow CD34-positive cells stimulated by growth factors, but not mature peripheral blood cells, exhibit high KIF20A expression...
September 4, 2018: International Journal of Hematology
Kentaro Watanabe, Yuki Arakawa, Eiji Oguma, Taichi Uehara, Masato Yanagi, Chigusa Oyama, Yuhachi Ikeda, Koji Sasaki, Kiyotaka Isobe, Makiko Mori, Ryoji Hanada, Katsuyoshi Koh
Intrathecal administration of methotrexate (IT-MTX) can lead to neurotoxicity. MTX-induced neurotoxicity occasionally manifests with a stroke-like presentation that is difficult to distinguish from genuine stroke. We retrospectively reviewed records of nine patients with leukemia or lymphoma and episodes of stroke-like presentation at our institute between 2010 and 2015 for whom magnetic resonance imaging (MRI) data were available. Coagulation test results were compared between the two diagnostic groups. Four patients were diagnosed with MTX-induced stroke-like neurotoxicity...
September 4, 2018: International Journal of Hematology
Kosei Matsue, Kyoya Kumagai, Isamu Sugiura, Takayuki Ishikawa, Tadahiko Igarashi, Tsutomu Sato, Michihiro Uchiyama, Toshihiro Miyamoto, Takaaki Ono, Yasunori Ueda, Toru Kiguchi, Yoshinori Sunaga, Toru Sasaki, Kenshi Suzuki
The affiliation of the last author, Kenshi Suzuki has been incorrectly published in the original publication of the article. The correct affiliation is provided in this correction.
August 30, 2018: International Journal of Hematology
Yosuke Minami
No abstract text is available yet for this article.
August 28, 2018: International Journal of Hematology
Kazuhito Suzuki, Nobuyuki Kobayashi, Yoji Ogasawara, Takaki Shimada, Yuichi Yahagi, Katsuki Sugiyama, Shinobu Takahara, Takeshi Saito, Jiro Minami, Hiroki Yokoyama, Yutaro Kamiyama, Atsushi Katsube, Kazuhiro Kondo, Hiroyuki Yanagisawa, Keisuke Aiba, Shingo Yano
Cancer-related fatigue (CRF) is one of the adverse events in multiple myeloma (MM) patients treated with cytotoxic agents, proteasome inhibitors (PIs), and immunomodulatory drugs (IMiDs) such as bortezomib, lenalidomide, and thalidomide. The aims of our study were to prospectively analyze the clinical significance of CRF, and to evaluate the cumulative incidence of CRF and the survival rates of 16 MM patients who were treated with PIs and IMiDs. Reactivation of salivary human herpes virus (HHV)-6 and HHV-7 was analyzed using real-time quantitative polymerase chain reaction (qPCR)...
August 28, 2018: International Journal of Hematology
Ai Inoue, Chiharu I Kobayashi, Haruka Shinohara, Kenichi Miyamoto, Nobuhiko Yamauchi, Junichiro Yuda, Yukihiro Akao, Yosuke Minami
Chronic myeloid leukemia (CML) is effectively treated with tyrosine kinase inhibitors (TKI) targeted against BCR-ABL. We previously reported the investigation of residual CML diseases during TKI treatment using FACS-sorting and quantitative RT-PCR of BCR-ABL among each population; total mononuclear cells, hematopoietic stem cells, and myeloid progenitors. The observations also implied that the second-generation of ABL-tyrosine kinase inhibitors (2nd TKIs), dasatinib or nilotinib therapy can be more promising approach for efficient reduction of the CML stem cells...
August 28, 2018: International Journal of Hematology
Naoki Watanabe, Tomoiku Takaku, Kazuyoshi Takeda, Shuichi Shirane, Tokuko Toyota, Michiaki Koike, Masaaki Noguchi, Takao Hirano, Hiroshi Fujiwara, Norio Komatsu
Dasatinib induces lymphocytosis of large granular lymphocytes (LGLs) in a proportion of patients with chronic myelogenous leukemia (CML), and is associated with better clinical outcomes. LGLs consist of cytotoxic T lymphocytes and natural killer cells; however, the context and phenotypic/functional features of each type of LGL are unknown. To better define features of these LGLs, we investigated lymphocytosis in CML patients treated with dasatinib. D57-positive and CD4-positive type I T-helper (Th) cells (CD57+ Th cells) rarely occur in CML patients without lymphocytosis and in healthy individuals; however, a substantial increase in the proportion of CD57+ Th cells was observed in CML patients treated with dasatinib...
August 27, 2018: International Journal of Hematology
Tze King Tan, Chujing Zhang, Takaomi Sanda
TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Such precise control is crucial for the switching of the transcriptional program. The misexpression of TAL1 in immature thymocytes leads to a widespread series of orchestrated downstream events that affect several different cellular machineries, resulting in a lethal consequence, namely T-cell acute lymphoblastic leukemia (T-ALL)...
August 25, 2018: International Journal of Hematology
Jun Amaki, Tatsuya Sekiguchi, Shinichiro Hiraiwa, Hiroshi Kajiwara, Hidetsugu Kawai, Akifumi Ichiki, Naoya Nakamura, Kiyoshi Ando
Spontaneous splenic rupture is a rare but often life-threatening condition. However, there is no consensus on appropriate management for this condition, due to its rarity. Here, we report three cases of malignant lymphoma with spontaneous splenic rupture. In each case, progression of splenic bleeding was rapid and complicated by malignant lymphoma. Spontaneous splenic rupture complicated by malignant lymphoma may cause exacerbation of anemia and hypovolemic shock. When splenic rupture is indicated by abdominal pain, tachycardia, or hypotension in a patient with splenomegaly, abdominal examination should be performed immediately, and emergency transcatheter arterial embolization and/or splenectomy should be considered...
August 24, 2018: International Journal of Hematology
Andrea Piccin, Mario Tagnin, Cinzia Vecchiato, Ahmad Al-Khaffaf, Lisa Beqiri, Caroline Kaiser, Iris Agreiter, Giovanni Negri, Michael Kob, Angela Di Pierro, Fabio Vittadello, Guido Mazzoleni, Klaus Eisendle, Fabrizio Fontanella
Graft-versus-host disease (GvHD) causes severe mucositis, impairs feeding and favors infection. The objective of this study was to identify the impact of GvHD in the oral cavity. We reviewed all consecutive patients who developed oral GvHD after HSCT. The study period was over 14 years. 53 patients were identified. M/F = 1.4; median age was 48.6 years; the median follow-up was for up to 3 years and 6 months. Conditioning regimens included several drugs (e.g., busulfan, cyclophosphamide and fludarabine)...
August 24, 2018: International Journal of Hematology
Takuyo Kanayama, Toshihiko Imamura, Yasuhiro Kawabe, Shinya Osone, Junko Tahara, Fuminori Iwasaki, Naoyuki Miyagawa, Hiroaki Goto, Shinsaku Imashuku, Hajime Hosoi
Mixed lineage leukemia [MLL; now known as lysine methyltransferase 2A (KMT2A)] rearrangement-positive acute myeloid leukemia (AML) and juvenile myelomonocytic leukemia (JMML) are distinct diseases, although age of susceptibility (infancy or early childhood) and abnormal monocytosis are common clinical features. Here, we report two cases of KMT2A-rearranged infantile AML masquerading as JMML at initial presentation. Both cases showed leukocytosis accompanied by atypical monocytosis. However, in both cases, leukemic blasts were absent at the initial examination...
August 24, 2018: International Journal of Hematology
Yuzuru Kanakura, Yukari Shirasugi, Hiroki Yamaguchi, Michiaki Koike, Takaaki Chou, Shinichiro Okamoto, Heinrich Achenbach, Jingyang Wu, Chiaki Nakaseko
Cytoreductive therapy is used in high-risk essential thrombocythemia (ET) to reduce risk of thrombohemorrhagic complications. Anagrelide is an orally active, quinazolone-derived platelet-lowering agent approved for first-line treatment of high-risk ET in Japan. Long-term safety and efficacy data were collected from 53 Japanese high-risk ET patients (Study 308); 41 patients who completed Study 308 entered this phase 3b, open-label extension (Study 309; NCT01467661). Reductions in mean platelet counts occurred throughout the study, from 1021...
August 18, 2018: International Journal of Hematology
Kazuyuki Sato, Hirotaka Sakai, Yusuke Saiki, Akiko Uchida, Yu Uemura, Satoshi Yokoi, Yuka Tsuruoka, Yuji Nishio, Manabu Matsunawa, Yoshinori Suzuki, Yasushi Isobe, Masayuki Kato, Naoto Tomita, Yasuyuki Inoue, Ikuo Miura
In the original publication of the article, Table 2 was published incorrectly. The column names were swapped under the column heading "Prom (%)". The correct column names are PB and BM.
August 12, 2018: International Journal of Hematology
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