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International Journal of Gynecological Cancer

Roberto Angioli, Massimo Casciello, Salvatore Lopez, Francesco Plotti, Lidia Di Minco, Paola Frati, Vittorio Fineschi, Pierluigi Benedetti Panici, Giuseppe Scaletta, Stella Capriglione, Andrea Miranda, Laura Feole, Corrado Terranova
OBJECTIVE: Because of the widespread availability of the internet and social media, people often collect and disseminate news online making it important to understand the underlying mechanisms to steer promotional strategies in healthcare. The aim of this study is to analyze perceptions regarding the human papillomavirus (HPV) vaccine in Italy. METHODS: From August 2015 to July 2016, articles, news, posts, and tweets were collected from social networks, posts on forums, blogs, and pictures about HPV...
January 10, 2019: International Journal of Gynecological Cancer
Juan Luis Alcázar, María Caparros, Maria Arraiza, José Ángel Mínguez, Stefano Guerriero, Luis Chiva, Matías Jurado
OBJECTIVE: To compare the diagnostic performance of ultrasound and computed tomography (CT) for detecting pelvic and abdominal tumor spread in women with epithelial ovarian cancer. METHODS: An observational cohort study of 93 patients (mean age 57.6 years) with an ultrasound diagnosis of adnexal mass suspected of malignancy and confirmed histologically as epithelial ovarian cancer was undertaken. In all cases, transvaginal and transabdominal ultrasound as well as CT scans were performed to assess the extent of the disease within the pelvis and abdomen prior to surgery...
January 10, 2019: International Journal of Gynecological Cancer
Chikako Matsushita, Hiroyuki Fujiwara, Yuji Takei, Yasushi Saga, Shizuo Machida, Akiyo Taneichi, Suzuyo Takahashi, Takahiro Yoshiba, Takahiro Koyanagi, Yoshifumi Takahashi, Hiroyuki Morisawa, Mitsuaki Suzuki
OBJECTIVE: To establish new criteria for the omission of lymphadenectomy in patients with endometrioid carcinoma. METHODS:  We retrospectively reviewed 185 cases of histologically confirmed endometrioid carcinoma by hysterectomy at Jichi Medical University Hospital between January 2006 and December 2011. We reviewed patient medical records to detect risk factors for lymph node metastasis to identify the optimum criteria for lymphadenectomy omission. RESULTS: Univariate analysis revealed risk factors for lymph node metastasis to be a large tumor size (volume index ≥40 cm³) (p<0...
January 10, 2019: International Journal of Gynecological Cancer
Chrishanthi Rajasooriyar, Ming-Yin Lin, Rashi Kalra, Andrew Lim, Kailash Narayan
BACKGROUND: Patients selection for salvage hysterectomy following chemoradiotherapy of cervical cancer is vital to avoid significant morbidity. The purpose of this study was to describe the role of post-treatment F18-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scanning (FDG-PET/CT) in patient selection for salvage hysterectomy. METHODS: This was a retrospective analysis of 49 patients with cervical cancer treated between January 1996 and December 2012 who were candidates for salvage hysterectomy...
January 10, 2019: International Journal of Gynecological Cancer
Masaharu Hata
As the average lifespan lengthens worldwide, and the older adult population increases, the number of elderly patients with uterine cervical cancer is increasing. Because intensive and invasive treatments, including surgery, are frequently unacceptable in elderly patients, cancer treatments for these patients must be carefully considered. Elderly patients have undergone radiation therapy as less-invasive curative treatment, and it has been shown to be safe and effective for local control of cervical cancer in this population, even among patients aged ≥80 years treated with curative radiation doses...
January 10, 2019: International Journal of Gynecological Cancer
Kathleen N Moore, Sandro Pignata
BACKGROUND: There is mounting pre-clinical and clinical evidence that combinations of immunotherapy, specifically programed cell death-1 (PD-1) inhibition, with chemotherapy and anti-angiogenesis agents, such as bevacizumab, result in markedly improved outcomes across a variety of tumor types including endometrial cancer, renal cell cancer, and non-small cell lung cancer. IMagyn050/GOG 3015/ENGOT-OV39 is the first, randomized, phase III trial to evaluate the potential impact of this combination on both progression-free survival and overall survival in patients presenting with advanced epithelial ovarian cancer...
January 10, 2019: International Journal of Gynecological Cancer
Tamy Tiemi Suehiro, Natália Malaguti, Edilson Damke, Nelson Shozo Uchimura, Fabrícia Gimenes, Raquel Pantarotto Souza, Vânia Ramos Sela da Silva, Marcia Edilaine Lopes Consolaro
OBJECTIVE: To assess the rates of co-infections between human papillomavirus (HPV) and 13 key markers of bacterial vaginosis in cervical samples by multiplex polymerase chain reaction in a population with a high rate of abnormal cytology and a positive HPV test. METHODS: The study included a total of 213 women aged 18-72 years screened using Papanicolaou smears for determining cervical abnormalities and for HPV and bacterial vaginosis by single-target and multiplex polymerase chain reaction...
January 10, 2019: International Journal of Gynecological Cancer
Nanda Horeweg, Carien L Creutzberg, Eva C Rijkmans, Mirjam S Laman, Laura A Velema, Veronique L M A Coen, Tanja C Stam, Ellen M Kerkhof, Judith R Kroep, Cor D de Kroon, Remi A Nout
OBJECTIVE: To evaluate the efficacy and toxicity of primary chemoradiation with image-guided adaptive brachytherapy for locally advanced cervical cancer and to identify predictors of treatment failure and toxicity. METHODS: Retrospective analysis of 155 stage IB-IVA cervical cancer patients treated from 2008 to 2016 with chemoradiation and image-guided adaptive brachytherapy. Treatment consisted of external beam radiotherapy (45 - 48.6 Gy in 1.8 - 2 Gy fractions) with concurrent weekly cisplatin (40 mg/m2 , 5 - 6 cycles) and image-guided adaptive brachytherapy (3-4 × 7 Gy high dose rate) using intracavitary or combined intracavitary-interstitial techniques according to GEC-ESTRO (Group Européen de Curiethérapie and the European Society for Radiotherapy and Oncology) recommendations...
January 10, 2019: International Journal of Gynecological Cancer
Donata Grimm, Katharina Prieske, Sabrina Mathey, Sascha Kuerti, Eike Burandt, Barbara Schmalfeldt, Linn Woelber
OBJECTIVES: Superficially invasive stage IA squamous vulvar cancer (VSCC) is defined as a single lesion measuring ≤2 cm with a depth of invasion of ≤1.0 mm (FIGO stage IA). This article examines the natural course and prognosis of superficially invasive VSCC. METHODS: This is a retrospective case series of 46 patients (median age 58 years) with superficially invasive stage IA VSCC receiving wide local excision between January 1996 and November 2014 in the University Medical Center Hamburg-Eppendorf...
January 4, 2019: International Journal of Gynecological Cancer
Francesco Raspagliesi, Giorgio Bogani, Laura Matteucci, Jvan Casarin, Ilaria Sabatucci, Stefano Tamberi, Valentina Arcangeli, Giuseppa Maltese, Stefano Lepori, Giuseppe Comerci, Marco Stefanetti, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Domenica Lorusso
OBJECTIVE: The aim of the study was to evaluate outcomes of patients with unresectable advanced ovarian cancer experiencing complete response (CR) to neoadjuvant chemotherapy. METHODS: Data of consecutive patients undergoing neoadjuvant chemotherapy plus interval debulking surgery (IDS) were retrospectively reviewed in 4 Italian centers. Using a propensity-matching algorithm, we compared data of patients achieving CR with neoadjuvant chemotherapy (no macroscopic either microscopic residual disease (RD) at the time of IDS) with patients achieving partial response (PR)...
November 2018: International Journal of Gynecological Cancer
Elisabeth Maritschnegg, Florian Heitz, Nina Pecha, Jirí Bouda, Fabian Trillsch, Christoph Grimm, Adriaan Vanderstichele, Christiane Agreiter, Philipp Harter, Eva Obermayr, Ignace Vergote, Robert Zeillinger, Paul Speiser
OBJECTIVES: Poor survival of high-grade serous pelvic cancer is caused by a lack of effective screening measures. The detection of exfoliated cells from high-grade serous pelvic cancer, or precursor lesions, is a promising concept for earlier diagnosis. However, collecting those cells in the most efficient way while fulfilling all requirements for a screening approach is a challenge. We introduce a new catheter for uterine and tubal lavage (UtL) and the clinical evaluation of its performance...
November 2018: International Journal of Gynecological Cancer
Alexandros Rodolakis, Nikolaos Thomakos, Maria Sotiropoulou, Konstantinos Kypriotis, Dimitrios Valsamidis, Charis Bourgioti, Lia Evangelia Moulopoulou, Georgios Vlachos, Dimitrios Loutradis
OBJECTIVE: Treatment of pregnancy complication due to malignancy of the cervix constitutes a great clinical challenge between optimal maternal therapy and fetal viability. Radical trachelectomy in early-stage cervical cancer during pregnancy instead of radical hysterectomy presents an alternative approach that can offer a satisfactory outcome for the mother and fetus. MATERIALS AND METHODS-RESULTS: A literature search of articles in English has been performed. Until now, 28 women with cervical cancer, including 2 who were managed and treated in our institute, who underwent a radical trachelectomy during pregnancy have been reported...
November 2018: International Journal of Gynecological Cancer
Shannon MacLaughlan David, Nicole Marjon, Diana English, Natasha Purington, Summer S Han, Don S Dizon
OBJECTIVE: The aim of this study was to evaluate contemporary practices and opinions among gynecologic oncologists regarding the use of total pelvic exenteration (TPE) for palliative intent. METHODS: This cross-sectional study of the membership of the Society of Gynecologic Oncology utilized an electronic survey to assess the opinions and practice patterns of gynecologic oncologists regarding TPEs. The primary outcome was willingness to consider a TPE for palliative intent, and demographic and practice characteristics were collected for correlation...
November 2018: International Journal of Gynecological Cancer
Francesca Moro, Stefano Uccella, Antonia Carla Testa, Giovanni Scambia, Anna Fagotti
OBJECTIVE: Ovarian cancer is commonly diagnosed at an advanced stage. Complete macroscopic eradication of the disease is associated with improved prognosis. In this setting, the surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) can help to achieve cytoreduction to no gross residual disease. During surgery, CPLN removal is usually performed either via video-assisted thoracic surgery or through a large transdiaphragmatic or subxiphoid incision. In the present case, we propose the use of an intraoperative transdiaphragmatic ultrasound to confirm preoperative imaging and to obtain a precise localization of the suspicious CPLNs...
November 2018: International Journal of Gynecological Cancer
Thomas Bartl, Richard Schwameis, Anton Stift, Thomas Bachleitner-Hofmann, Alexander Reinthaller, Christoph Grimm, Stephan Polterauer
OBJECTIVES: The aims of this study were to assess anastomotic leakage (AL) rate and risk factors for AL in patients with advanced epithelial ovarian cancer (EOC) undergoing cytoreductive surgery including bowel resections and to evaluate the prognostic implication of AL. METHODS: Data of 350 consecutive patients with International Federation of Gynecology and Obstetrics EOC stage IIB-IV who underwent cytoreductive surgery at the Department of General Gynecology and Gynecologic Oncology of the General Hospital of Vienna between 2003 and 2017 were collected...
November 2018: International Journal of Gynecological Cancer
Marina Frimer, Eirwen M Miller, Viswanathan Shankar, Eugenia Girda, Keyur Mehta, Harriet O Smith, Dennis Y S Kuo, Gary L Goldberg, Mark H Einstein
OBJECTIVE: We prospectively evaluated patients with completely resected uterine serous carcinoma (USC) treated with radiation "sandwiched" between carboplatin/paclitaxel (C/T). The primary objective was to determine the safety profile, and the secondary outcome was to evaluate progression-free and overall survival. METHODS: Surgically staged patients with completely resected USC were enrolled to receive 3 cycles of paclitaxel 175 mg/m and carboplatin (area under the curve, 6-7...
November 2018: International Journal of Gynecological Cancer
Selçuk Erkilinç, Volkan Karataşli, Batuhan Demir, İlker Çakir, Behzat Can, Tuğba Karadeniz, Mehmet Gökçü, Muzaffer Sanci
OBJECTIVE: This study aimed to evaluate the outcomes of rectosigmoid resection (RR) and Douglas peritonectomy (DP) on postoperative complications and survival in advanced-stage ovarian cancer surgery. METHODS/MATERIALS: Patients who underwent optimal cytoreductive surgery including RR and DP between January 2007 and January 2013 were included. Patients with deeper invasion into the muscularis and mucosal layer reported in pathology results and colon wall injury necessitating suturing or resection suggesting invasion of implants into the colon wall were excluded...
November 2018: International Journal of Gynecological Cancer
James May, Karolina Skorupskaite, Mario Congiu, Nidal Ghaoui, Graeme A Walker, Scott Fegan, Cameron W Martin, Rachel Louise O'Donnell
OBJECTIVES: Since the recognition of borderline ovarian tumors (BOTs) in the 1970s, the management of this subset of epithelial ovarian tumors has presented a challenge to clinicians. The majority present at an early stage, but their diagnosis is often only made following surgery, hence the heterogeneity of surgical management. Borderline ovarian tumors are morphologically diverse, and their behavior is subsequently also heterogeneous. We aimed to assess recurrence rates and the rate of malignant transformation in patients diagnosed with BOT...
November 2018: International Journal of Gynecological Cancer
Li Sun, Ning Li, Yan Song, Guixiang Wang, Zitong Zhao, Lingying Wu
OBJECTIVE: This study aimed to evaluate the clinicopathologic features of mucinous borderline ovarian tumors (MBOTs), with an emphasis on the risk factors for recurrence. METHODS: Data of 76 patients with MBOT diagnosed and treated between 2000 and 2007 at a single institution were analyzed in this retrospective study. The clinicopathologic features of different tumor subgroups were analyzed, including pathology, surgical methodology, recurrence, and overall survival...
November 2018: International Journal of Gynecological Cancer
Elisabeth Smogeli, Milada Cvancarova, Yun Wang, Ben Davidson, Gunnar Kristensen, Kristina Lindemann
OBJECTIVES: Adjuvant treatment of high-risk endometrial cancer (EC) is still controversial. Several studies have tried to clarify the best treatment strategy, and guidelines have been made, but no study to date has shown a survival benefit for radiation over chemotherapy. We aimed to evaluate the outcome of high-risk EC patients treated with adjuvant chemotherapy only in a population where the routine administration of adjuvant radiotherapy was omitted. METHODS: This is a retrospective study including 230 EC patients with International Federation of Gynecology and Obstetrics stage I type II, stage Ib type I/G3, stage II, and IIIc treated at Oslo University Hospital between 2005 and 2012...
November 2018: International Journal of Gynecological Cancer
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