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International Journal of Gynecological Cancer

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https://www.readbyqxmd.com/read/28072594/genetics-consultation-rates-following-a-diagnosis-of-high-grade-serous-ovarian-carcinoma-in-the-canadian-province-of-ontario
#1
Jacob McGee, Karen Panabaker, Sean Leonard, Peter Ainsworth, Laurie Elit, Salimah Z Shariff
OBJECTIVE: In 2001, the province of Ontario expanded cancer genetic testing eligibility to include all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum. The aim of this study was to determine the proportion of women who attended genetics counseling for consideration of BRCA1/2 gene analysis. We also sought to examine if regional differences in consultation rate exist across administrative health regions in the province of Ontario. METHODS: We identified all women with a pathological diagnosis of HGSC in the province of Ontario between 1997 until 2011...
January 9, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28060142/the-importance-of-appendectomy-in-surgery-for-mucinous-adenocarcinoma-of-the-ovary
#2
Mikkel Rosendahl, Laura Amalie Haueberg Oester, Claus Kim Høgdall
OBJECTIVE: The aim of this study was to assess the importance of appendectomy during surgery for mucinous ovarian cancer. It can be difficult to distinguish between primary ovarian and primary appendiceal cancers clinically, histologically, and immunohistochemically. Removal of the appendix may facilitate differential diagnosis, improve staging, and possibly increase 5-year survival but may also be associated with increased postsurgical morbidity. In the largest population published to date, we analyze and discuss these matters...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28060141/pd-l1-expression-in-premalignant-and-malignant-trophoblasts-from-gestational-trophoblastic-diseases-is-ubiquitous-and-independent-of-clinical-outcomes
#3
Pierre-Adrien Bolze, Sophie Patrier, Jérôme Massardier, Touria Hajri, Fatima Abbas, Anne Marie Schott, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Gilles Freyer, François Golfier, Benoît You
OBJECTIVE: Recently reported expression of programmed cell death 1 ligand 1 (PD-L1) in gestational trophoblastic diseases (GTDs) suggests that the immune tolerance of pregnancy might be hijacked during neoplastic process. We assessed PD-L1 protein expression in premalignant and malignant GTD lesions and analyzed associations with disease severity and chemotherapy outcomes. METHODS: We included 83 GTD whole-tissue sections from 76 patients in different treatment settings...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28060140/gynecologic-oncologist-views-influencing-referral-to-outpatient-specialty-palliative-care
#4
Casey M Hay, Carolyn Lefkowits, Megan Crowley-Matoka, Marie A Bakitas, Leslie H Clark, Linda R Duska, Renata R Urban, Lee-May Chen, Stephanie L Creasy, Yael Schenker
OBJECTIVE: Early specialty palliative care is underused for patients with advanced gynecologic malignancies. We sought to understand how gynecologic oncologists' views influence outpatient specialty palliative care referral to help inform strategies for improvement. METHODS/MATERIALS: We conducted a qualitative interview study at 6 National Cancer Institute-designated cancer centers with well-established outpatient palliative care services. Between September 2015 and March 2016, 34 gynecologic oncologists participated in semistructured telephone interviews focused on attitudes, experiences, and preferences related to outpatient specialty palliative care...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28060139/is-older-age-a-real-adverse-prognostic-factor-in-women-with-early-stage-endometrial-carcinoma-a-matched-analysis
#5
Laura Haley, Charlotte Burmeister, Thomas Buekers, Mohamed A Elshaikh
OBJECTIVES: The aim of this study was to evaluate if older age alone negatively impacts survival endpoints in women with early-stage uterine endometrioid carcinoma (EC), or its reported prognostic impact is due to an interaction with other well-known adverse factors using matched-analysis methodology. METHODS: We identified 1254 patients with International Federation of Gynecology and Obstetrics stage I-II EC who underwent hysterectomy at our institution. We created 2 matched groups based on International Federation of Gynecology and Obstetrics stage, tumor grade, lymph node dissection status, and the type of adjuvant management...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27997455/cervical-cancer-screening-with-human-papillomavirus-dna-and-cytology-in-japan
#6
Yuri Sasaki, Osamu Iwanari, Ichiro Arakawa, Takuya Moriya, Yoshiki Mikami, Kuniko Iihara, Ryo Konno
OBJECTIVE: The aim of this study was to determine the value of human papillomavirus (HPV) testing for primary cervical cancer screening in Japan. METHODS: In total, 5065 women who underwent primary screening with cytology and HPV between January 2005 and December 2006 were enrolled. In the baseline phase, these women were stratified by age, and the rates of HPV-positive and abnormal cytology were compared between women younger than and older than 30 years. In the follow-up phase, women aged 20 to 69 years and cytology negative for intraepithelial lesions or malignancy at baseline were followed up until December 2011 (n = 2383)...
December 16, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984379/is-neurosurgery-with-adjuvant-radiotherapy-an-effective-treatment-modality-in-isolated-brain-involvement-from-endometrial-cancer-from-case-report-to-analysis
#7
Gunsu Kimyon, Taner Turan, Derman Basaran, Osman Turkmen, Alper Karalok, Tolga Tasci, Gokhan Tulunay, Mehmet Faruk Kose
AIM: The aim of this study was to evaluate the treatment options and post-brain involvement survival (PBIS) of patients with isolated brain involvement from endometrial cancer (EC). MATERIALS AND METHODS: The literature electronic search was conducted from 1972 to May 2016 to identify articles about isolated (without extracranial metastases) brain involvement from EC at recurrence and the initial diagnosis. Forty-eight articles were found. After comprehensive evaluation of case series and case reports, the study included 49 cases...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984378/analysis-of-conservative-surgical-treatment-and-prognosis-of-microinvasive-squamous-cell-carcinoma-of-the-cervix-stage-ia1-results-of-follow-up-to-20-years
#8
Caio Augusto Hartman, Julio Cesar Teixeira, Sergio Bruno Barbosa, Stephanye Mariano Figueiredo, Liliana Aparecida Lucci De Angelo Andrade, Joana Froes Bragança Bastos
OBJECTIVE: The aim of this study was to evaluate the prognosis and recurrence of microinvasive squamous cervical (MIC) cancer stage IA1 in women treated conservatively or by hysterectomy, and followed-up to 20 years. METHODS: It was studied in a cohort of 139 women with MIC, 41 definitively managed by conization and 98 by hysterectomy from January 1994 to December 2003 and followed-up until 2013. The definitive treatment, age, conization technique (loop electrosurgical excision procedure or cold knife conization), cone margin, residual disease in hysterectomy specimen, and the association with recurrence (intraepithelial cervical neoplasia grade 3/intraepithelial vaginal neoplasia grade 3 or worse, and microinvasive or worse) were analyzed...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984377/weekly-versus-triweekly-cisplatin-based-chemotherapy-concurrent-with-radiotherapy-in-the-treatment-of-cervical-cancer-a-meta-analysis
#9
Xingxing Chen, Haizhou Zou, Huifang Li, Ruifang Lin, Meng Su, Wenyi Zhang, Yongqiang Zhou, Ping Zhang, Meng Hou, Xia Deng, Changlin Zou
BACKGROUND: The aim of this study was to evaluate toxicity, compliance, recurrence and the survival of weekly and triweekly cisplatin-based concomitant chemoradiation in treatment of cervical cancer. MATERIALS AND METHODS: The databases were searched from 1995 until 2015 to identify eligible studies on weekly versus triweekly cisplatin chemoradiotherapy. The data were analyzed by RevMan 5.3 software. RESULTS: A total of 5 randomized controlled trials were included in this review...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984376/long-term-morbidity-and-quality-of-life-in-cervical-cancer-survivors-a-multicenter-comparison-between-surgery-and-radiotherapy-as-primary-treatment
#10
Marloes Derks, Luc R C W van Lonkhuijzen, Rinske M Bakker, Anne M Stiggelbout, Cornelis D de Kroon, Henrike Westerveld, Jan Paul W R Roovers, Gemma G Kenter, Moniek M Ter Kuile
OBJECTIVE: To compare long-term morbidity and quality of life after primary surgery or primary radiotherapy for stage IB/II cervical cancer. METHODS: A cross-sectional study was performed. Patients treated for stage IB/II cervical cancer between 2000 and 2010 were approached to participate. Primary treatment consisted of radical hysterectomy with pelvic lymphadenectomy (RHL), for selected cases followed by adjuvant (chemo-)radiotherapy, or primary (chemo)radiotherapy (PRT)...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984375/survival-after-pelvic-exenteration-for-cervical-cancer-a-national-cancer-database-study
#11
Stephen Graves, Brandon-Luke L Seagle, Anna E Strohl, Shohreh Shahabi, Wilberto Nieves-Neira
OBJECTIVE: To determine overall survival (OS) and factors associated with OS after pelvic exenteration for cervical cancer. METHODS: Women with cervical cancer who underwent exenteration (n = 517) were identified from the 1998 to 2011 National Cancer Database. Kaplan-Meier and multivariate Cox proportional-hazards survival analyses were performed to test for associations of potential explanatory variables with OS. Analyzed confounders included age, insurance status, income, distance from home to treatment center, stage, exenteration type, surgical margin status, and treatment with adjuvant radiation and/or chemotherapy...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984374/cd56-neural-cell-adhesion-molecule-expression-in-ovarian-carcinomas-association-with-high-grade-and-advanced-stage-but-not-with-neuroendocrine-differentiation
#12
Hans-Christian Bösmüller, Philipp Wagner, Deborah Lam Pham, Anna K Fischer, Karen Greif, Christine Beschorner, Bence Sipos, Falko Fend, Annette Staebler
OBJECTIVE: Neural cell adhesion molecule (CD56) has been proposed as a potential marker for neuroendocrine differentiation in carcinomas, together with synaptophysin and chromogranin A. However, CD56 immunoreactivity by itself can be found in a broad variety of tumors, including ovarian neoplasms. CD56 has recently been suggested as a potential target for antibody-based therapy. However, for ovarian carcinoma, there is only limited data available regarding the pattern of CD56 immunoreactivity, coexpression of neuroendocrine markers, and correlation with histological types and clinical parameters...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27984373/hnrnpa1-a-splicing-regulator-is-an-effective-target-protein-for-cervical-cancer-detection-comparison-with-conventional-tumor-markers
#13
Young-Jon Kim, Byoung-Ryun Kim, Jae-Suk Ryu, Gyeong-Ok Lee, Hak-Ryul Kim, Keum-Ha Choi, Jae-Won Ryu, Kyoung-Suk Na, Min-Cheol Park, Hong-Seob So, Ji-Hyun Cho, Do-Sim Park
OBJECTIVE: Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), serine/arginine-rich splicing factor 1 (SRSF1), and SRSF3 are splicing regulators associated with oncogenesis. However, the alterations of SF proteins and their diagnostic values in cervical cancer are unclear. To apply SFs clinically, effective marker selection and characterization of the target organ properties are essential. MATERIALS AND METHODS: We concurrently analyzed HNRNPA1, SRSF1, SRSF3, and the conventional tumor markers squamous cell carcinoma antigen (SCCA) and carcinoembryonic antigen (CEA) in cervical tissue samples (n = 127) using semiquantitative immunoblotting...
December 15, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922982/mir-21-is-overexpressed-in-hydatidiform-mole-tissues-and-promotes-proliferation-migration-and-invasion-in-choriocarcinoma-cells
#14
Ya-Xin Wang, Jiu-Ru Zhao, Yue-Ying Xu, Wei-Bin Wu, Hui-Juan Zhang
OBJECTIVE: The aims of this study were to make clear whether miR-21 was dysregulated in hydatidiform mole (HM) tissues and choriocarcinoma (CCA) cells, to elucidate whether aberrant miR-21 expression would affect the function of CCA cells, and to find out whether there was a relationship between miR-21 and AKT, PDCD4, and PTEN in CCA cells. METHODS: Fresh and formalin-fixed, paraffin-embedded trophoblastic tissues (normal first trimester placentas and HMs) were retrieved from the biobank in the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922981/second-opinion-expert-pathology-in-endometrial-cancer-potential-clinical-implications
#15
Friederike Grevenkamp, Felix Kommoss, Friedrich Kommoss, Sigurd Lax, Falko Fend, Diethelm Wallwiener, Birgitt Schönfisch, Bernhard Krämer, Sara Y Brucker, Florin-Andrei Taran, Annette Staebler, Stefan Kommoss
OBJECTIVE: In cancer patients, the pathology report serves as an important basis for treatment. Therefore, a correct cancer diagnosis is crucial, and diagnostic discrepancies may be of clinical relevance. It was the aim of this study to perform a specialized histopathology review and to investigate potential clinical implications of expert second opinion pathology in endometrial cancer. METHODS: Patients treated for endometrial carcinoma at the Tübingen University Women's hospital between 2003 and 2013 were identified...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922978/significance-of-monocyte-counts-at-recurrence-on-survival-outcome-of-women-with-endometrial-cancer
#16
Hiroko Machida, Madushka Yohan De Zoysa, Tsuyoshi Takiuchi, Marianne S Hom, Katherine E Tierney, Koji Matsuo
OBJECTIVE: Tumor-associated macrophages (TAMs) are known to have adverse effects on the survival of women with endometrial cancer. Because monocytes function as progenitors of macrophages, this study examined the association between monocyte count at the first recurrence/progression of endometrial cancer and survival time after recurrence/progression (SAR). METHODS: This is a retrospective study evaluating 141 consecutive cases of recurrent endometrial cancer after surgical staging (n = 114) and progression after nonsurgical management (n = 27)...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27922975/influence-of-body-mass-index-on-tumor-pathology-and-survival-in-uterine-cancer-a-danish-register-study
#17
Anne Bjerrum Kristensen, Helle Hare-Bruun, Claus Kim Høgdall, Martin Rudnicki
OBJECTIVE: To evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer. DESIGN: Register study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003). MAIN OUTCOME MEASURES: Impact of BMI on type I and II endometrial cancer survival...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27870715/posttranscriptional-control-of-pd-l1-expression-by-17%C3%AE-estradiol-via-pi3k-akt-signaling-pathway-in-er%C3%AE-positive-cancer-cell-lines
#18
Lingyun Yang, Feng Huang, Jiandong Mei, Xun Wang, Qiuyang Zhang, Hongjing Wang, Mingrong Xi, Zongbing You
OBJECTIVE: Estrogen is a well-known oncogenic driver in endometrial (ECs) and breast cancers (BCs). Programmed cell death protein 1 (PD-1) and its ligands PD-1 Ligand 1 (PD-L1) and PD-L2 have been shown to mediate immune evasion of the tumor cells. The purpose of the present study was to assess the effects of estrogen on PD-L1 and PD-L2 expression in EC and BC cell lines. METHODS: 17β-Estradiol (E2)-induced expression of PD-L1 and PD-L2 and possible signaling pathway were investigated in EC and BC cells...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27870712/a-phase-2-randomized-open-label-study-of-irosustat-versus-megestrol-acetate-in-advanced-endometrial-cancer
#19
Patricia Pautier, Ignace Vergote, Florence Joly, Bohuslav Melichar, Elzbieta Kutarska, Geoffrey Hall, Anna Lisyanskaya, Nicholas Reed, Ana Oaknin, Valerijus Ostapenko, Zanete Zvirbule, Eric Chetaille, Agnès Geniaux, Muhammad Shoaib, John A Green
OBJECTIVE: Advanced/metastatic or recurrent endometrial cancer has a poor prognosis. Malignant endometrial tissue has high steroid sulphatase (STS) activity. The aim of this study was to evaluate STS as a therapeutic target in patients with endometrial cancer. METHODS: This was a phase 2, multicenter, international, open-label, randomized (1:1), 2-arm study of the STS inhibitor oral irosustat 40 mg/d versus oral megestrol acetate 160 mg/d in women with advanced/metastatic or recurrent estrogen receptor-positive endometrial cancer...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27870710/histopathology-discrepancy-of-preoperative-endometrial-sampling-and-final-specimen-how-does-this-influence-selective-lymph-node-dissection
#20
Bradley R Corr, Aakriti Carrubba, Jeanelle Sheeder, Georgina Cheng, Saketh R Guntupalli
OBJECTIVE: Preoperative histology is a major component in the perioperative selective lymph node (LN) dissection decision process. Discrepancy between preoperative endometrial sampling and final specimen histopathology is generally accepted. The goals of this project are to determine if discrepancy of histopathology is associated with alteration of adjuvant treatment or outcome. MATERIALS AND METHODS: We performed a retrospective cross-sectional analysis of all patients undergoing surgery for endometrial cancer at a single institution from 2010 to 2014...
November 17, 2016: International Journal of Gynecological Cancer
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