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International Journal of Gynecological Cancer

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https://www.readbyqxmd.com/read/28704326/single-marital-status-and-infectious-mortality-in-women-with-cervical-cancer-in-the-united-states
#1
Hiroko Machida, Sarah E Eckhardt, Antonio V Castaneda, Erin A Blake, Huyen Q Pham, Lynda D Roman, Koji Matsuo
OBJECTIVE: Unmarried status including single marital status is associated with increased mortality in women bearing malignancy. Infectious disease weights a significant proportion of mortality in patients with malignancy. Here, we examined an association of single marital status and infectious mortality in cervical cancer. METHODS: This is a retrospective observational study examining 86,555 women with invasive cervical cancer identified in the Surveillance, Epidemiology, and End Results Program between 1973 and 2013...
July 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708791/self-reported-long-term-autonomic-function-after-laparoscopic-total-mesometrial-resection-for-early-stage-cervical-cancer-a-multicentric-study
#2
Alessandro Lucidi, Swetlana Windemut, Marco Petrillo, Margherita Dessole, Giulio Sozzi, Giuseppe Filiberto Vercellino, Kaven Baessler, Giuseppe Vizzielli, Jalid Sehouli, Giovanni Scambia, Vito Chiantera
OBJECTIVES: This multicentric retrospective study investigates the early and long-term self-reported urinary, bowel, and sexual dysfunctions in early-stage cervical cancer patients who submitted to laparoscopic total mesometrial resection (L-TMMR), total laparoscopic radical hysterectomy, vaginal-assisted laparoscopic radical hysterectomy, and laparoscopic-assisted radical vaginal hysterectomy. METHODS: Cervical cancer patients, FIGO (International Federation of Gynecology and Obstetrics) stage IA2-IB1/IIA1 who submitted to nerve-sparing radical hysterectomy were recruited...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708790/trends-of-gynecological-cancers-in-turkey-towards-europe-or-asia
#3
Murat Gultekin, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Selin Dundar, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
OBJECTIVE: The aim of this study was to evaluate nationwide gynecological cancer trends in Turkey. METHODS: National cancer registry data (2009-2013) of Turkish Ministry of Health were evaluated. Ovarian, cervical, endometrial, vulvar, vaginal, and tubal cancers are evaluated with respect to age of diagnosis, incidence rates within years, stage, histological distributions, and mortality rates. Data were collected from active cancer registry centers, which increased from 23% in 2009 to 47...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708789/letter-to-the-editor-on-management-of-para-aortic-lymph-node-disease-in-patients-with-cervical-cancer-what-is-the-best-approach-int-j-gynecol-cancer-2017-mar-27-3-543549
#4
Elodie Chantalat, Fabien Vidal, Stéphanie Motton
No abstract text is available yet for this article.
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708788/therapy-modalities-prognostic-factors-and-outcome-of-the-primary-cervical-carcinosarcoma-meta-analysis-of-extremely-rare-tumor-of-cervix
#5
Gunsu Kimyon Comert, Osman Turkmen, Alper Karalok, Derman Basaran, Dilek Bulbul, Taner Turan
OBJECTIVE: The aim of this study was to evaluate the prognostic factors, treatment options, and survival outcomes of primary carcinosarcomas of the uterine cervix. METHODS: An electronic search of the literature was conducted from 1951 to February 2017 to identify articles on primary cervical carcinosarcoma. After comprehensive evaluation of case series and case reports, 81 cases were included in the study. RESULTS: The most common clinical FIGO (International Federation of Gynecology and Obstetrics) stage was IB at 53% of cases...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708787/factors-contributing-to-the-low-survival-among-women-with-a-diagnosis-of-invasive-cervical-cancer-in-ghana
#6
Yvonne Nartey, Philip C Hill, Kwabena Amo-Antwi, Kofi M Nyarko, Joel Yarney, Brian Cox
: Cervical cancer is one of the most common cancers among women worldwide, and more than 85% of the disease occurs in low- and middle-income countries. Although it ranks as the most common cancer in Ghanaian women, there are no data available on cervical cancer survival. METHODS: Information on women with a diagnosis of cervical cancer from 2010 to 2013 was collected from the Komfo Anokye and Korle-Bu Teaching Hospitals through review of paper-based and electronic medical records (including pathology records) at the oncology units and the departments of obstetrics and gynecology...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708786/venous-thromboembolism-in-patients-receiving-extended-pharmacologic-prophylaxis-after-robotic-surgery-for-endometrial-cancer
#7
Josephine S Kim, Kathryn A Mills, Julia Fehniger, Chuanhong Liao, Jean A Hurteau, Carolyn V Kirschner, Nita K Lee, Gustavo C Rodriguez, S Diane Yamada, Elena S Diaz Moore, Meaghan E Tenney
OBJECTIVE: This study aims to determine the rate of postoperative venous thromboembolism (VTE) in endometrial cancer patients undergoing robotic hysterectomy with or without extended pharmacologic VTE prophylaxis. METHODS/MATERIALS: A retrospective chart review of women undergoing robotic hysterectomy with or without other procedures for endometrial cancer from January 2010 to February 2015 was conducted at 2 institutions. Charts were manually abstracted, and rates of VTE within 30 and 60 days after surgery were determined...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708785/y-box-binding-protein-1-promotes-epithelial-mesenchymal-transition-invasion-and-metastasis-of-cervical-cancer-via-enhancing-the-expressions-of-snail
#8
Tianyun Pang, Min Li, Ye Zhang, Weiwei Yong, Haixian Kang, Yunhong Yao, Xinrong Hu
OBJECTIVE: Y box-binding protein 1 (YB-1) is a potent oncogenic protein. How it regulates Snail in most tumors including cervical cancer is unknown. This article is to study if YB-1 plays a role in cervical cancer via regulating the expression of Snail. METHODS: Immunohistochemical staining of YB-1, Snail, and E-cadherin (E-cad) was performed on tissue specimens including 35 cases of chronic cervicitis (as a control), 35 cases of cervical intraepithelial neoplasm (CIN) I, 35 cases of CIN II/III, 28 cases of unmetastatic cervical squamous cell carcinoma, and 19 cases of metastatic cervical squamous cell carcinoma...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704329/long-term-oncological-outcome-after-conventional-radical-hysterectomy-versus-2-nerve-sparing-modalities-for-early-stage-cervical-cancer
#9
Mignon Dingena Johanna Maria van Gent, Mandy Rademaker, Johanna Cornelia Bernadette van der Veer, Mariëtte Inie Elizabeth van Poelgeest, Katja Nicoline Gaarenstroom, Hein Putter, Johannes Baptist Maria Zacharias Trimbos, Cor Doede de Kroon
OBJECTIVES: Nerve-sparing radical hysterectomy for early stage cervical cancer was introduced to improve quality of life after treatment. Sparing the pelvic autonomic nerves reduces bladder, bowel, and sexual dysfunction. The Leiden nerve-sparing radical hysterectomy (LNSRH) was modified to the Swift procedure, the latter being more radical regarding the sacrouterine and parametrial resection. We investigate whether nerve-sparing surgery has comparable oncological outcomes as the conventional radical hysterectomy (CRH)...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704328/randomized-controlled-trial-of-dexamethasone-versus-dexamethasone-plus-hydrocortisone-as-prophylaxis-for-hypersensitivity-reactions-due-to-paclitaxel-treatment-for-gynecologic-cancer
#10
Dhammapoj Jeerakornpassawat, Prapaporn Suprasert
OBJECTIVE: The aim of this study was to assess intravenous hydrocortisone (HCT) added to standard dexamethasone (DXM) prophylaxis for paclitaxel-associated hypersensitivity reactions (HSRs). METHODS: Paclitaxel naives scheduled for 6 cycles of paclitaxel (plus platinum) were randomized to DXM alone (20 mg intravenously [IV]) versus DXM plus HCT (100 mg IV) as premedication including chlorpheniramine (10 mg IV), diphenhydramine (25 mg orally), and ranitidine (50 mg IV) 30 minutes before infusion...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704327/examining-the-effects-of-time-to-diagnosis-income-symptoms-and-incidental-detection-on-overall-survival-in-epithelial-ovarian-cancer-manitoba-ovarian-cancer-outcomes-moco-study-group
#11
Alon D Altman, Pascal Lambert, Allison J Love, Donna Turner, Robert Lotocki, Erin Dean, Shaundra Popowich, Mark W Nachtigal
OBJECTIVE: The primary objectives of this study were to analyze data on time to diagnosis and correlate this with overall survival. We secondarily analyzed the effects of emergency room visits, symptoms, incidental findings, residence, socioeconomic status, and residual disease on overall survival. METHODS: This retrospective population-based descriptive cohort study examined all invasive ovarian cancer cases in Manitoba, Canada, between 2004 and 2010. Clinicopathologic, socioeconomic, and outcome data were collected...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704325/clinical-utility-of-preoperative-computed-tomography-in-patients-with-endometrial-cancer
#12
Giorgio Bogani, Bobbie S Gostout, Sean C Dowdy, Francesco Multinu, Jvan Casarin, William A Cliby, Luigi Frigerio, Bohyun Kim, Amy L Weaver, Gretchen E Glaser, Andrea Mariani
OBJECTIVE: The aim of this study was to determine the clinical utility of routine preoperative pelvic and abdominal computed tomography (CT) examinations in patients with endometrial cancer (EC). METHODS: We retrospectively reviewed records from patients with EC who underwent a preoperative endometrial biopsy and had surgery at our institution from January 1999 through December 2008. In the subset with an abdominal CT scan obtained within 3 months before surgery, we evaluated the clinical utility of the CT scan...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704324/fascin-is-associated-with-aggressive-behavior-and-poor-outcome-in-uterine-carcinosarcoma
#13
Abby M Richmond, Erin A Blake, Kathleen Torkko, Elizabeth E Smith, Monique A Spillman, Miriam D Post
OBJECTIVE: The mechanisms underlying the histogenesis and aggressiveness of uterine carcinosarcoma (UCS) are poorly understood; however, previous studies implicate epithelial-mesenchymal transition (EMT). Fascin is a proinvasive, actin-bundling protein and an important component of EMT. It is associated with poor outcomes in human carcinoma, especially in estrogen receptor (ER)-negative tumors arising in organs normally expressing ER. We sought to evaluate fascin expression in UCS and its relationship to ER status, clinicopathologic indicators of tumor aggressiveness, and survival outcomes...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704323/time-trends-in-the-incidence-and-mortality-of-ovarian-cancer-in-ireland-northern-ireland-and-israel-1994-2013
#14
Lital Keinan-Boker, Barbara G Silverman, Paul M Walsh, Anna T Gavin, Catherine Hayes
OBJECTIVES: The aims of this study were to compare time trends in ovarian cancer incidence and mortality in populations with (1) similar genetics but different health care systems (Ireland and Northern Ireland [NI]) and (2)different genetics but similar health care system (Israeli Jews and Arabs) and to interpret the results. METHODS: Age-standardized rates of ovarian cancer incidence and mortality for 1994-2013 in the 3 countries were obtained from national cancer registries and national statistics...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28704322/malignant-bowel-obstruction-in-relapsed-ovarian-cancer-with-peritoneal-carcinomatosis-an-occlusive-state
#15
Pedro Martinez Castro, Lara Vargas, Antonio Mancheño, Salvador Martín Utrilla, Francisco Pascual, Ignacio Romero, Cristina Zorrero, José Manuel Bosch, Andrés Poveda, Lucas Minig
OBJECTIVE: The aim of this study was to describe the clinical and oncological outcomes of women with malignant bowel obstruction (MBO) for relapsed ovarian cancer and peritoneal carcinomatosis. METHODS: A retrospective cohort study was performed in all consecutive patients admitted at Instituto Valenciano de Oncología, Valencia, Spain, between July 2013 and July 2016 with MBO for relapsed ovarian cancer and peritoneal carcinomatosis. All patients underwent the same protocol of conservative management...
July 12, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692638/the-first-nationwide-multicenter-prevalence-study-of-germline-brca1-and-brca2-mutations-in-chinese-ovarian-cancer-patients
#16
Xiaohua Wu, Lingying Wu, Beihua Kong, Jihong Liu, Rutie Yin, Hao Wen, Ning Li, Hualei Bu, Yanling Feng, Qingli Li, Xuesong Lu, Jia Wei, Xuehua Zhu, John Mills, Gillian Ellison, Thorsten Gutjahr, Yuzhen Liu
OBJECTIVE: Subjects with germline BRCA1/2 mutations (gBRCAm) have an increased risk of developing ovarian cancer and enhanced sensitivity to platinum-containing agents and PARP (poly[ADP-ribose] polymerase) inhibitors. BRCA mutations in Asian patients are poorly understood compared with other populations. We aimed to investigate gBRCAm prevalence and characteristics in Chinese ovarian cancer patients. METHODS: We conducted the first nationwide multicenter gBRCAm prevalence study in China...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692637/comparison-of-2-human-chorionic-gonadotropin-immunoassays-commercially-available-for-monitoring-patients-with-gestational-trophoblastic-disease
#17
Juliana Maria Quinalha de Souza, Antonio Braga, Rafael Sanches Dos Santos, Marcos Montanha Ramos, Rafael Cortés-Charry, Izildinha Maestá
OBJECTIVE: The aim of this study was to compare serum human chorionic gonadotropin (hCG) levels in patients with gestational trophoblastic disease (GTD) using 2 commercially available hCG immunoassays. METHODS: Serum samples were obtained from patients with GTD attending the Botucatu Medical School Trophoblastic Diseases Center of São Paulo State University (UNESP), from November 2014 to October 2015. Serum hCG levels were measured with both Architect i2000SR and Immulite 2000 XPi chemiluminescence assays...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692636/the-effect-of-thymoquinone-on-apoptosis-of-sk-ov-3-ovarian-cancer-cell-by-regulation-of-bcl-2-and-bax
#18
Xiaoli Liu, Jinhu Dong, Wangyu Cai, Ying Pan, Ruili Li, Bing Li
OBJECTIVE: We aim to determine how cisplatin, thymoquinone (TQ), and combination regimen can affect apoptosis of cultured SK-OV-3 cells. We also want to explore the mechanism of these influences on the cells' apoptosis by Bcl-2 and Bax gene. METHOD/MATERIALS: Cell Counting Kit-8 assay was used to measure the viability of cultured ovarian cancer cells. Propidium iodide with flow cytometry was used in cell cycle analysis. Thereafter, we used fluorescein isothiocyanate-stained annexin V and propidium iodide to detect the effect of cisplatin, TQ, and combination regimen on apoptosis...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692635/resisting-recist-uniformity-versus-clinical-validity
#19
Michelle K Wilson, Michael L Friedlander, Stephanie Lheureux, William Small, Andrés Poveda, Eric Pujade-Lauraine, Katherine Karakasis, Monica Bacon, Valerie Bowering, Tanya Chawla, Amit M Oza
OBJECTIVES: The Response Evaluation Criteria in Solid Tumors (RECIST) International Working Group developed criteria for tumor response and progression to standardize radiological assessment in patients receiving chemotherapy in phase 2 trials. However, it is unclear whether the defined percentage change in tumor size and volume reflects true clinical benefit for the patient. The RECIST criteria were designed to improve objectivity in trials, but not to replace clinical decision making...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692634/targeting-foxm1-improves-cytotoxicity-of-paclitaxel-and-cisplatinum-in-platinum-resistant-ovarian-cancer
#20
Gina L Westhoff, Yi Chen, Nelson N H Teng
OBJECTIVE: Aberrantly activated FOXM1 (forkhead box protein M1) leading to uncontrolled cell proliferation and dysregulation of FOXM1 transcription network occurs in 84% of ovarian cancer cases. It was demonstrated that thiostrepton, a thiazole antibiotic, decreases FOXM1 expression. We aimed to determine if targeting the FOXM1 pathway with thiostrepton could improve the efficacy of paclitaxel and cisplatin in human ovarian cancer ascites cells ex vivo. METHODS: Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed...
July 7, 2017: International Journal of Gynecological Cancer
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