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International Journal of Gynecological Cancer

Anna Fagotti, Carmine Conte, Francesca Stollagli, Valerio Gallotta, Vanda Salutari, Carolina Bottoni, Matteo Bruno, Gian Franco Zannoni, Giovanni Scambia
BACKGROUND: Platinum-based chemotherapy plus bevacizumab is the new standard of care in stage IVB cervical cancer (CC) patients. In this new scenario, radical surgery could be offered in selected cases with an optimal clinical response. Potential surgical complications related to previous bevacizumab treatment have never been described before in this type of setting. METHODS: This is a single-institutional retrospective study on women with CC who received radical pelvic surgery after platinum-based chemotherapy (platinum-taxol) plus bevacizumab...
August 29, 2018: International Journal of Gynecological Cancer
Joke Hellinga, Nienke C Te Grootenhuis, Paul M N Werker, Geertruida H de Bock, Ate G J van der Zee, Maaike H M Oonk, Martin W Stenekes
OBJECTIVE: Resection of (pre) malignant lesions in the vulvoperineal area may result in large defects that cannot be closed primarily. The lotus petal flap technique is widely used for reconstruction. The aim of this study was to evaluate both quality of life (QoL) and sexual functioning of patients who underwent the lotus petal flap procedure, because no data are available on this topic. METHODS: A cross-sectional study was performed on all eligible patients (N = 38) who underwent the lotus petal flap procedure between 2005 and 2016...
August 29, 2018: International Journal of Gynecological Cancer
Kathleen Gong Essel, Aaron Shafer, Amanda Bruegl, David M Gershenson, Lane K Drury, Lois M Ramondetta, R Wendel Naumann, Jubilee Brown
OBJECTIVE: The aim of this study was to determine the utility of surgery in patients with gestational trophoblastic neoplasia (GTN). MATERIALS AND METHODS: We performed a retrospective institutional review board-approved analysis of all patients with GTN at a single institution from 1985 to 2015 and compared all patients who underwent surgery as definitive management for their disease to a matched cohort of those who did not. Kaplan-Meier curves were used to estimate progression-free survival (PFS) and overall survival (OS)...
August 29, 2018: International Journal of Gynecological Cancer
Weiping Wang, Xiaoliang Liu, Qingyu Meng, Fuquan Zhang, Ke Hu
OBJECTIVE: The aim of the study was to evaluate the efficacy and toxicity of prophylactic extended-field radiation therapy (RT) for cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). METHODS: Records of patients with cervical cancer without para-aortic metastatic lymph nodes who were treated with definitive RT or CCRT between January 2011 and December 2014 were reviewed. Patients were classified into the pelvic RT and extended-field RT groups...
August 27, 2018: International Journal of Gynecological Cancer
Fujun He, Juan Du, Xia Chen, Linsheng He
OBJECTIVE: The objective of this study was to develop a predictive model for parametrial involvement (PMI) and to identify low-risk group of PMI in early stages of cervical cancer based on preoperative magnetic resonance imaging (MRI) parameters. METHODS: We retrospectively analyzed patients with stages IB1 to IIA2 cervical cancer (N = 1347) who underwent type C radical hysterectomy between 2005 and 2012. Clinical records, preoperative MRI, and its association with pathological data were reviewed...
August 27, 2018: International Journal of Gynecological Cancer
Zakia A Abdelhamed, Thomas A Ryan, Martin Fuller, Camilla Coulson-Gilmer, Dina I Abdelmottaleb, Tian-Li Wang, Jen-Chun Kaun, Peiyi Wang, Richard Hutson, Nafisa Wilkinson, Sandra M Bell, Colin A Johnson
OBJECTIVES: The aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial carcinoma (STIC). METHODS: Fallopian tube tissue samples were obtained from 4 females undergoing prophylactic hysterectomies and 6 patients diagnosed with STIC. A mogp-TAg transgenic mouse STIC sample was also compared with a wild-type mouse FT sample. Serous tubal intraepithelial carcinoma was identified by hematoxylin and eosin staining and confirmed by positive Ki-67 and p53 immunohistochemical staining of tissue sections...
August 8, 2018: International Journal of Gynecological Cancer
Vanessa Carlson, Leslea Walters, Pascal Lambert, Erin Dean, Robert Lotocki, Alon D Altman
OBJECTIVES: The aim of this study was to review the treatment and outcomes of low-risk gestational trophoblastic neoplasia (GTN) in Manitoba over more than 3 decades, with a focus on those treated with alternating methotrexate and dactinomycin, a protocol that has only rarely been described. MATERIALS AND METHODS: We retrospectively reviewed all patients with GTN referred to CancerCare Manitoba from January 1977 to December 2012. Cases were classified as low risk as per the modified WHO-FIGO prognostic scoring system (score, ≤6)...
August 7, 2018: International Journal of Gynecological Cancer
Haruko Iwase, Seigi Furukawa, Takeshi Hirasawa, Satoshi Asai, Tatsuru Ohara, Shinji Hosonuma, Shinichi Endo, Yuki Tazo, Hidetaka Sato, Toshio Takada, Masahide Arai, Masae Ikeda, Masako Shida, Norihito Yoshioka, Akiko Tozawa-Ono, Nao Suzuki, Mikio Mikami, Takashi Onda
OBJECTIVE: Chemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent endometrial cancer (REC) patients in Japan. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 112 REC patients who were primarily treated at 1 of 3 university hospitals in Japan from 2005 to 2012. We analyzed overall survival since the first recurrence (R-OS) in accordance with several factors...
August 7, 2018: International Journal of Gynecological Cancer
Aygun Babayeva, Elena Ioana Braicu, Jacek P Grabowski, Khayal Gasimli, Rolf Richter, Mustafa Zelal Muallem, Jalid Sehouli
OBJECTIVE: The aim of this study was to estimate surgical outcome and survival benefit after completion surgery. METHODS: We evaluated 164 patients with epithelial ovarian cancer who underwent incomplete primary cytoreductive surgery or rather received only staging procedures from January 2000 to December 2014 in outside institutions. Patient-related data were registered in prospective database of Tumor Bank Ovarian Cancer. The outcome analyses were performed for early and advanced stages of ovarian cancer separately...
August 7, 2018: International Journal of Gynecological Cancer
Annick Pina, Robert Wolber, Jessica N McAlpine, Blake Gilks, Janice S Kwon
OBJECTIVE: There is uncertainty about the prognostic significance of mismatch repair (MMR) deficiency in endometrial cancer. The objective was to evaluate clinical characteristics and outcomes of endometrial cancers based on MMR status within a population-based study. METHODS: This was a retrospective population-based cohort study of all endometrial cancer cases from the Vancouver Coastal Health Authority region, evaluated for 4 MMR proteins using immunohistochemistry from 2012 to 2015...
August 7, 2018: International Journal of Gynecological Cancer
Dimitrios Nasioudis, Konstantinos Lontos, Anastasia Tsagianni, Michael Boyiadzis, Emily M Ko
OBJECTIVE: The aim of the present study was to estimate the risk of therapy-related acute myeloid leukemia (t-AML) in patients with gynecologic malignancies receiving chemotherapy using a population-based database. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results database was accessed, and a cohort of women diagnosed with a primary ovarian, uterine, or cervical malignancy between January 1, 1992, and December 31, 2014, who received chemotherapy was selected...
August 7, 2018: International Journal of Gynecological Cancer
Alexandra L Martin, J Ryan Stewart, Harshitha Girithara-Gopalan, Jeremy T Gaskins, Nicole J McConnell, Erin E Medlin
OBJECTIVES: The objective of this study was to determine complications associated with primary closure compared with reconstruction after vulvar excision and predisposing factors to these complications. METHODS: Patients undergoing vulvar excision with or without reconstruction from 2011 to 2015 were abstracted from the National Surgical Quality Improvement Program database. Common Procedural Terminology codes were used to characterize surgical procedures as vulvar excision alone or vulvar excision with reconstruction...
August 7, 2018: International Journal of Gynecological Cancer
Natsuo Tomita, Mika Mizuno, Chiyoko Makita, Shinji Kondo, Masahiko Mori, Jun Sakata, Hirofumi Tsubouchi, Kimiko Hirata, Hiroyuki Tachibana, Takeshi Kodaira
OBJECTIVE: The aim of this study was to compare the outcomes and toxicities of radical hysterectomy (RH) and definitive chemoradiation (CRT) for International Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical cancer. MATERIALS AND METHODS: A retrospective analysis was performed on FIGO stage IIB patients who underwent RH with adjuvant radiotherapy (surgery group) or intended to receive CRT (CRT group). The distributions of disease-free survival (DFS) and overall survival (OS) were calculated using the Kaplan-Meier method...
August 7, 2018: International Journal of Gynecological Cancer
Varun Mittal, Shradha Ahuja, Sai Sharath Vejella, Jessica M Stempel, Venkataraman Palabindala, Claudia M Dourado, John C Leighton
OBJECTIVE: Venous thromboembolism (VTE) is a major cause of mortality and morbidity in hospitalized patients with malignancy. Nationwide Inpatient Sample database was analyzed to determine the trends in the rate of hospitalization and mortality from VTE in hospitalized ovarian cancer patients and assess its economic impact and resource utilization. METHOD: We queried the 2003 to 2011 Nationwide Inpatient Sample database from Healthcare Cost and Utilization project (Agency of Healthcare Research and Quality) to identify all adults (age ≥18 years) ovarian cancer...
July 24, 2018: International Journal of Gynecological Cancer
Monica Gomes Ferreira, Magdalena Sancho de Salas, Rogelio González Sarmiento, Maria José Doyague Sánchez
OBJECTIVE: Ovarian cancer is the deadliest of gynecologic cancers. In recent years, International Federation of Gynecology and Obstetrics (FIGO) and the World Health Organization (WHO) classifications were revised. We compared the major changes between the classifications and examined the effects on the therapy and prognosis of the ovarian, fallopian tubes, and peritoneum cancer in our series according to both classifications. METHODS/MATERIALS: We performed an observational descriptive study of 210 patients who were diagnosed with a malignant ovarian tumor from 2010 to 2016...
July 24, 2018: International Journal of Gynecological Cancer
Xinxin Zhu, Ling Zhao, Jinghe Lang
OBJECTIVE: This study aimed to assess the relationship between BRCA1 gene methylation, PD-L1 protein expression, and the clinicopathologic features of sporadic ovarian cancer (OC). METHODS: Bisulfite pyrosequencing and immunohistochemistry were used to detect BRCA1 gene methylation and PD-L1 protein expression, respectively, in tumor tissues from 112 patients with sporadic OC. Their levels were analyzed against clinicopathologic characteristics and prognosis using standard statistical methods...
July 24, 2018: International Journal of Gynecological Cancer
Xiao-Li Chen, Guang-Wen Chen, Guo-Hui Xu, Jing Ren, Zhen-Lin Li, Hong Pu, Hang Li
OBJECTIVE: To determine whether gross tumor volume (GTV) and the maximum diameter of resectable cervical cancer at magnetic resonance imaging (MRI) could predict lymph node metastasis (LNM) and lymphovascular space invasion (LVSI). MATERIALS AND METHODS: A total of 315 consecutive patients with cervical cancer were retrospectively identified. Gross tumor volume and the maximum diameter of tumor were evaluated on MRI. Univariate and multivariate logistic regression analyses were performed to determine whether tumor size could predict LNM and LVSI...
July 23, 2018: International Journal of Gynecological Cancer
Cristina Iftode, Giuseppe R DʼAgostino, Angelo Tozzi, Tiziana Comito, Ciro Franzese, Fiorenza De Rose, Davide Franceschini, Lucia Di Brina, Stefano Tomatis, Marta Scorsetti
OBJECTIVE: Stereotactic body radiation therapy (SBRT) has been successfully used to treat oligometastases of several primary tumors, but few experiences have been described in patients with gynecological oligometastatic cancer, particularly in ovarian neoplasm. The aim of this study was to evaluate the role of this new radiotherapy modality in a series of oligometastatic ovarian cancer patients. MATERIALS AND METHODS: Clinical records of patients affected by oligometastatic ovarian carcinoma treated with SBRT were reviewed...
July 20, 2018: International Journal of Gynecological Cancer
Vasilios Pergialiotis, Nikoleta Karampetsou, Ioannis Bellos, Nikolaos Thomakos, Georgios Daskalakis
OBJECTIVE: Human epididymis factor-4 (HE4) has been studied in the field of ovarian cancer with promising results during the last decade. The purpose of the present meta-analysis is to investigate the diagnostic accuracy of HE4, in terms of sensitivity and specificity, as a minimally invasive method to predict optimal debulking in women that experience ovarian cancer. METHODS: We used the Medline (1966-2017), Scopus (2004-2017), EMBASE, (2008-2017) and Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases in our primary search, along with the reference lists of electronically retrieved full-text articles...
July 20, 2018: International Journal of Gynecological Cancer
Beatriz Guerreiro Ruiz Castro, Ricardo Dos Reis, Geórgia Fontes Cintra, Mileide Maria de Assunção Sousa, Marcelo de Andrade Vieira, Carlos Eduardo Mattos da Cunha Andrade
OBJECTIVE: Postoperative complications and adjuvant chemotherapy delay (ACD) are the most damaging outcomes after surgical treatment of advanced ovarian cancer. Establishing predictive factors should prevent their occurrence. METHODS: We analyzed retrospectively all patients with advanced ovarian cancer who underwent cytoreduction at our institution between December 2010 and May 2016. We evaluated all 30-day complications and considered ACD all cases who did not start adjuvant chemotherapy until 42 days or did not perform it after cytoreductive surgery...
July 20, 2018: International Journal of Gynecological Cancer
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