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International Journal of Gynecological Cancer

Francesco Raspagliesi, Giorgio Bogani, Laura Matteucci, Jvan Casarin, Ilaria Sabatucci, Stefano Tamberi, Valentina Arcangeli, Giuseppa Maltese, Stefano Lepori, Giuseppe Comerci, Marco Stefanetti, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Domenica Lorusso
OBJECTIVE: The aim of the study was to evaluate outcomes of patients with unresectable advanced ovarian cancer experiencing complete response (CR) to neoadjuvant chemotherapy. METHODS: Data of consecutive patients undergoing neoadjuvant chemotherapy plus interval debulking surgery (IDS) were retrospectively reviewed in 4 Italian centers. Using a propensity-matching algorithm, we compared data of patients achieving CR with neoadjuvant chemotherapy (no macroscopic either microscopic residual disease (RD) at the time of IDS) with patients achieving partial response (PR)...
November 2018: International Journal of Gynecological Cancer
Elisabeth Maritschnegg, Florian Heitz, Nina Pecha, Jirí Bouda, Fabian Trillsch, Christoph Grimm, Adriaan Vanderstichele, Christiane Agreiter, Philipp Harter, Eva Obermayr, Ignace Vergote, Robert Zeillinger, Paul Speiser
OBJECTIVES: Poor survival of high-grade serous pelvic cancer is caused by a lack of effective screening measures. The detection of exfoliated cells from high-grade serous pelvic cancer, or precursor lesions, is a promising concept for earlier diagnosis. However, collecting those cells in the most efficient way while fulfilling all requirements for a screening approach is a challenge. We introduce a new catheter for uterine and tubal lavage (UtL) and the clinical evaluation of its performance...
November 2018: International Journal of Gynecological Cancer
Alexandros Rodolakis, Nikolaos Thomakos, Maria Sotiropoulou, Konstantinos Kypriotis, Dimitrios Valsamidis, Charis Bourgioti, Lia Evangelia Moulopoulou, Georgios Vlachos, Dimitrios Loutradis
OBJECTIVE: Treatment of pregnancy complication due to malignancy of the cervix constitutes a great clinical challenge between optimal maternal therapy and fetal viability. Radical trachelectomy in early-stage cervical cancer during pregnancy instead of radical hysterectomy presents an alternative approach that can offer a satisfactory outcome for the mother and fetus. MATERIALS AND METHODS-RESULTS: A literature search of articles in English has been performed. Until now, 28 women with cervical cancer, including 2 who were managed and treated in our institute, who underwent a radical trachelectomy during pregnancy have been reported...
November 2018: International Journal of Gynecological Cancer
Shannon MacLaughlan David, Nicole Marjon, Diana English, Natasha Purington, Summer S Han, Don S Dizon
OBJECTIVE: The aim of this study was to evaluate contemporary practices and opinions among gynecologic oncologists regarding the use of total pelvic exenteration (TPE) for palliative intent. METHODS: This cross-sectional study of the membership of the Society of Gynecologic Oncology utilized an electronic survey to assess the opinions and practice patterns of gynecologic oncologists regarding TPEs. The primary outcome was willingness to consider a TPE for palliative intent, and demographic and practice characteristics were collected for correlation...
November 2018: International Journal of Gynecological Cancer
Francesca Moro, Stefano Uccella, Antonia Carla Testa, Giovanni Scambia, Anna Fagotti
OBJECTIVE: Ovarian cancer is commonly diagnosed at an advanced stage. Complete macroscopic eradication of the disease is associated with improved prognosis. In this setting, the surgical resection of enlarged cardiophrenic lymph nodes (CPLNs) can help to achieve cytoreduction to no gross residual disease. During surgery, CPLN removal is usually performed either via video-assisted thoracic surgery or through a large transdiaphragmatic or subxiphoid incision. In the present case, we propose the use of an intraoperative transdiaphragmatic ultrasound to confirm preoperative imaging and to obtain a precise localization of the suspicious CPLNs...
November 2018: International Journal of Gynecological Cancer
Thomas Bartl, Richard Schwameis, Anton Stift, Thomas Bachleitner-Hofmann, Alexander Reinthaller, Christoph Grimm, Stephan Polterauer
OBJECTIVES: The aims of this study were to assess anastomotic leakage (AL) rate and risk factors for AL in patients with advanced epithelial ovarian cancer (EOC) undergoing cytoreductive surgery including bowel resections and to evaluate the prognostic implication of AL. METHODS: Data of 350 consecutive patients with International Federation of Gynecology and Obstetrics EOC stage IIB-IV who underwent cytoreductive surgery at the Department of General Gynecology and Gynecologic Oncology of the General Hospital of Vienna between 2003 and 2017 were collected...
November 2018: International Journal of Gynecological Cancer
Marina Frimer, Eirwen M Miller, Viswanathan Shankar, Eugenia Girda, Keyur Mehta, Harriet O Smith, Dennis Y S Kuo, Gary L Goldberg, Mark H Einstein
OBJECTIVE: We prospectively evaluated patients with completely resected uterine serous carcinoma (USC) treated with radiation "sandwiched" between carboplatin/paclitaxel (C/T). The primary objective was to determine the safety profile, and the secondary outcome was to evaluate progression-free and overall survival. METHODS: Surgically staged patients with completely resected USC were enrolled to receive 3 cycles of paclitaxel 175 mg/m and carboplatin (area under the curve, 6-7...
November 2018: International Journal of Gynecological Cancer
Selçuk Erkilinç, Volkan Karataşli, Batuhan Demir, İlker Çakir, Behzat Can, Tuğba Karadeniz, Mehmet Gökçü, Muzaffer Sanci
OBJECTIVE: This study aimed to evaluate the outcomes of rectosigmoid resection (RR) and Douglas peritonectomy (DP) on postoperative complications and survival in advanced-stage ovarian cancer surgery. METHODS/MATERIALS: Patients who underwent optimal cytoreductive surgery including RR and DP between January 2007 and January 2013 were included. Patients with deeper invasion into the muscularis and mucosal layer reported in pathology results and colon wall injury necessitating suturing or resection suggesting invasion of implants into the colon wall were excluded...
November 2018: International Journal of Gynecological Cancer
James May, Karolina Skorupskaite, Mario Congiu, Nidal Ghaoui, Graeme A Walker, Scott Fegan, Cameron W Martin, Rachel Louise O'Donnell
OBJECTIVES: Since the recognition of borderline ovarian tumors (BOTs) in the 1970s, the management of this subset of epithelial ovarian tumors has presented a challenge to clinicians. The majority present at an early stage, but their diagnosis is often only made following surgery, hence the heterogeneity of surgical management. Borderline ovarian tumors are morphologically diverse, and their behavior is subsequently also heterogeneous. We aimed to assess recurrence rates and the rate of malignant transformation in patients diagnosed with BOT...
November 2018: International Journal of Gynecological Cancer
Li Sun, Ning Li, Yan Song, Guixiang Wang, Zitong Zhao, Lingying Wu
OBJECTIVE: This study aimed to evaluate the clinicopathologic features of mucinous borderline ovarian tumors (MBOTs), with an emphasis on the risk factors for recurrence. METHODS: Data of 76 patients with MBOT diagnosed and treated between 2000 and 2007 at a single institution were analyzed in this retrospective study. The clinicopathologic features of different tumor subgroups were analyzed, including pathology, surgical methodology, recurrence, and overall survival...
November 2018: International Journal of Gynecological Cancer
Elisabeth Smogeli, Milada Cvancarova, Yun Wang, Ben Davidson, Gunnar Kristensen, Kristina Lindemann
OBJECTIVES: Adjuvant treatment of high-risk endometrial cancer (EC) is still controversial. Several studies have tried to clarify the best treatment strategy, and guidelines have been made, but no study to date has shown a survival benefit for radiation over chemotherapy. We aimed to evaluate the outcome of high-risk EC patients treated with adjuvant chemotherapy only in a population where the routine administration of adjuvant radiotherapy was omitted. METHODS: This is a retrospective study including 230 EC patients with International Federation of Gynecology and Obstetrics stage I type II, stage Ib type I/G3, stage II, and IIIc treated at Oslo University Hospital between 2005 and 2012...
November 2018: International Journal of Gynecological Cancer
Yohann Dabi, Touria Hajri, Jérôme Massardier, Mélodie Mathé, Benoît You, Jean-Pierre Lotz, Sophie Patrier, Yassemine Khawajkie, Anne Marie Schott, François Golfier, Pierre-Adrien Bolze
OBJECTIVE: This study aimed to assess the outcome of first-line hysterectomy in patients diagnosed as having gestational trophoblastic neoplasia (GTN) whose postoperative imaging showed lung images considered as metastases. METHODS: From 1999 to 2016, patients no longer wishing to conceive, treated by their initial physician by hysterectomy, and whose postoperative imaging workup showed lung images considered as metastasis were identified in the French Trophoblastic Disease Reference Center database...
November 2018: International Journal of Gynecological Cancer
Giuseppe Vizzielli, Emanuele Perrone, Sara Pizzacalla, Giovanni Scambia, Alfredo Ercoli
STUDY OBJECTIVE: The video article describes a laparoscopic anterior pelvic exenteration with radical vaginectomy using the 3-dimensional (3D) vision and multifunction instruments. METHODS: This is a step-by-step video presentation of the laparoscopic anterior pelvic exenteration (Canadian Task Force classification III). Although the therapeutic benefit of the PE remains controversial, it is often performed in women with centrally recurrent pelvic tumors that previously received radiation therapy or in the locally advanced cases (ie, stage IIb-IVa) resistant to radiochemotherapy...
November 2018: International Journal of Gynecological Cancer
Munetoshi Akazawa, Sachiko Onjo
OBJECTIVES: Malignant transformation of mature cystic teratoma (MCT) is rare. Unlike squamous cell carcinoma (SCC) in MCT, the other types of neoplasm in MCT have not been discussed in publications. We analyzed the clinical characteristics and prognosis of the other types of neoplasm (non-SCC) compared with those of SCC. METHODS: A systematic literature search of literature published from 2000 to 2017 was conducted in PubMed, Web of Science, and Scopus. We reviewed case series that included all pathological types of malignant transformation...
November 2018: International Journal of Gynecological Cancer
Sonali Kaushik, Luke Hounsome, Catherine Blinman, Robert Gornall, Julia Verne
OBJECTIVE: The aim of this study was to develop a predictive model for risk of death in hospital for gynecological cancer patients specifically examining the impact of sociodemographic factors and emergency admissions to inform patient choice in place of death. METHODS: The model was based on data from 71,269 women with gynecological cancer as underlying cause of death in England, January 1, 2000, to July 1, 2012, in a national Hospital Episode Statistics-Office for National Statistics database...
November 2018: International Journal of Gynecological Cancer
Menghan Zhu, Nan Jia, Yanyan Nie, Jun Chen, Yahui Jiang, Tianjiao Lv, Yuanyuan Li, Liangqing Yao, Weiwei Feng
OBJECTIVE: High-risk endometrial cancers (ECs), including high-grade EC, serous carcinoma (SC), clear cell carcinoma, and carcinosarcoma, account for 50% of deaths due to ECs. Therapies for these cancers are limited, and patient-derived tumor xenograft (PDTX) models are useful tools for preclinical drug evaluation, biomarker identification, and personalized medicine strategies. Here, we used and compared 2 methods to establish PDTX models. METHODS: Fresh tumor tissues collected from 18 primary high-risk EC patients (10 high-grade ECs, 6 SCs, 1 clear cell carcinoma, and 1 carcinosarcoma) were engrafted subcutaneously and in the subrenal capsule in NOD/SCID for establishment and Balb/c-nu/nu mice for expansion...
November 2018: International Journal of Gynecological Cancer
Casey M Hay, Heidi S Donovan, Erin G Hartnett, Jeanne Carter, Mary C Roberge, Grace B Campbell, Benjamin E Zuchelkowski, Sarah E Taylor
OBJECTIVE: Sexual health is important to quality of life; however, the sexual health of gynecologic cancer patients is infrequently and inadequately addressed. We sought to understand patient experiences and preferences for sexual health care to help inform strategies for improvement. METHODS/MATERIALS: An anonymous, cross-sectional survey of outpatient gynecologic cancer patients at a large academic medical center was performed as part of a larger study examining patient and caregiver needs...
November 2018: International Journal of Gynecological Cancer
Hirokazu Usui, Jia Qu, Asuka Sato, Zijun Pan, Akira Mitsuhashi, Hideo Matsui, Makio Shozu
OBJECTIVE: The aim of this study was to evaluate the incidence and risk factors of gestational trophoblastic neoplasia (GTN) from hydatidiform moles (HMs) cytogenetically diagnosed in a prospective cohort setting. METHODS: The prospective observational cohort study included cases of cytogenetically defined molar pregnancies, which were diagnosed by a multiplex short tandem repeat polymorphism analysis. Cases were classified as androgenetic complete HMs (CHMs), diandric monogynic triploid partial HMs (PHMs), or biparental abortion...
November 2018: International Journal of Gynecological Cancer
Tomomi Egawa-Takata, Kiyoshi Yoshino, Kosuke Hiramatsu, Satoshi Nakagawa, Satoshi Serada, Aya Nakajima, Hiroko Endo, Satoshi Kubota, Shinya Matsuzaki, Eiji Kobayashi, Yutaka Ueda, Eiichi Morii, Masahiro Inoue, Tetsuji Naka, Tadashi Kimura
OBJECTIVE: The phenotypic and pathological features of small cell cervical carcinoma (SMCC) and small small cell lung cancer (SCLC) are very similar; thus, the chemotherapy regimens used for the rare SMCC have been routinely based on regimens used for common SCLC. We set out to explore the protein expression profile similarities between these 2 cancers to prove that linking their therapeutic regimens is justified, with a secondary aim of finding tumor-specific proteins to use as additional biomarkers for more accurate diagnosis of SMCC, and potentially to use as therapeutic targets...
November 2018: International Journal of Gynecological Cancer
Hee-Jung Jung, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVES: The aim of this study was to compare surgical and oncologic outcomes of open and laparoscopic surgery in patients with borderline ovarian tumors (BOTs). MATERIALS AND METHODS: This study included patients with BOTs who underwent open (n = 433) or laparoscopic (n = 210) surgery between 1990 and 2015. Surgical outcomes, perioperative morbidity, and disease-free survival and overall survival were compared. RESULTS: There was no significant difference in age, histologic type of tumor, and laterality of tumor...
November 2018: International Journal of Gynecological Cancer
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