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International Journal of Gynecological Cancer

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https://www.readbyqxmd.com/read/28617687/preoperatively-assessable-clinical-and-pathological-risk-factors-for-parametrial-involvement-in-surgically-treated-figo-stage-ib-iia-cervical-cancer
#1
Emel Canaz, Eser Sefik Ozyurek, Baki Erdem, Merve Aldikactioglu Talmac, Ipek Yildiz Ozaydin, Ozgur Akbayir, Ceyhun Numanoglu, Volkan Ulker
OBJECTIVE: Determining the risk factors associated with parametrial involvement (PMI) is of paramount importance to decrease the multimodality treatment in early-stage cervical cancer. We investigated the preoperatively assessable clinical and pathological risk factors associated with PMI in surgically treated stage IB1-IIA2 cervical cancer. METHODS: A retrospective cohort study of women underwent Querleu-Morrow type C hysterectomy for cervical cancer stage IB1-IIA2 from 2001 to 2015...
June 14, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604461/chemosensitivity-of-brca1-mutated-ovarian-cancer-cells-and-established-cytotoxic-agents
#2
Caroline van Haaften, Jaap van Eendenburg, Arnoud Boot, Willem E Corver, Lucien Haans, Tom van Wezel, J Baptist Trimbos
OBJECTIVE: Serous adenocarcinomas that arise in patients with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 are initially well treatable with platinum/paclitaxel. For recurrent disease in patients with BRCA1 or BRCA2 mutations, olaparib treatment is available. To study additional therapeutic regimens, a better understanding of the cellular and molecular mechanisms of the tumors in in vitro models is important. METHODS/MATERIALS: From a high-grade serous ovarian tumor of a BRCA1 mutation carrier, we established 3 distinct cell line subclones, OVCA-TR3...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604460/intention-to-treat-analysis-of-radical-trachelectomy-for-early-stage-cervical-cancer-with-special-reference-to-oncologic-failures-single-institutional-experience-in-hungary
#3
Robert Póka, Szabolcs Molnár, Péter Daragó, János Lukács, Rudolf Lampé, Zoárd Krasznai, Zoltán Hernádi
OBJECTIVE: The aim of our study was to evaluate clinical and pathological data in order to draw eligibility criteria for oncologically sufficient radical trachelectomy (RT) in early-stage cervical cancer. Reviewing all cases of attempted RT performed at our unit, we focused attention on prognostic indicators of the need for additional oncologic treatment following RT. The analysis was extended by extensive literature review to include previously published cases of oncologic failures. METHODS: The authors retrospectively analyzed data of patients who underwent RT at the Department of Obstetrics and Gynecology, University of Debrecen...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604459/definitive-chemoradiotherapy-in-elderly-cervical-cancer-patients-a-multiinstitutional-analysis
#4
Ozan Cem Guler, Sezin Yuce Sari, Sumerya Duru Birgi, Melis Gultekin, Ferah Yildiz, Cem Onal
OBJECTIVE: The aim of the study was to investigate the prognostic factors for survival and treatment-related toxicities in older (≥65 years) cervical cancer patients treated with definitive chemoradiotherapy. In addition, we sought to compare the outcomes between the older elderly (≥75 years) and their younger old counterparts (age, 65-74 years). MATERIALS AND METHODS: We retrospectively reviewed medical records from 269 biopsy-proven nonmetastatic cervical cancer patients treated with external radiotherapy and intracavitary brachytherapy at the departments of radiation oncology in 2 different universities...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604458/factors-associated-with-radiation-treatment-compliance-for-women-with-cervical-cancer-in-a-safety-net-health-system
#5
Alfredo Echeverria, Haley Manley, Barrett OʼDonnell, Joshua Asper, Mark Bonnen, Michelle Ludwig
OBJECTIVE: The aim of the study was to determine whether patient characteristics are associated with radiation treatment noncompliance. METHODS/MATERIALS: We retrospectively studied 244 patients with cervical cancer treated with chemoradiation between May 2006 and August 2015 at a safety net health center. Compliance with treatment was defined as missing less than 2 days of scheduled radiation. RESULTS: Treatment records revealed a compliance rate of 50...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604457/up-regulation-of-transcription-factor-3-is-correlated-with-poor-prognosis-in-cervical-carcinoma
#6
Liwen Luo, Hongyu Zhang, Songwen Nian, Chaoqun Lv, Bing Ni, Dan Wang, Zhiqiang Tian
OBJECTIVES: Transcription factor 3 (TCF3, or E2A) is a multifunctional bHLH (basic helix loop helix) transcription factor. The role of TCF3 expression in cancer and the multiple cell signaling pathways that regulate or are influenced by TCF3 are unclear. Therefore, the expression level of TCF3 in patients with cervical squamous cell carcinoma (CSCC) is discussed in this study. METHODS: Total RNA was extracted using real-time quantitative reverse transcription-polymerase chain reaction...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604456/urinary-polyamines-as-biomarkers-for-ovarian-cancer
#7
Riikka Johanna Niemi, Antti N Roine, Merja R Häkkinen, Pekka S Kumpulainen, Tuomo A Keinänen, Jouko J Vepsäläinen, Terho Lehtimäki, Niku K Oksala, Johanna U Mäenpää
OBJECTIVES: Elevated concentrations of polyamines have been found in urine of patients with malignant tumors, including ovarian cancer. Previous research has suffered from poorly standardized detection methods. Our liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is capable of simultaneous standardized analysis of most known polyamines. Liquid chromatography-tandem mass spectrometry has not previously been used in the differential diagnostics of ovarian tumors in postmenopausal women...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604455/oncologic-outcomes-after-adjuvant-radiotherapy-for-stage-ii-endometrial-carcinoma-a-korean-radiation-oncology-group-study-krog-14-10
#8
Jinhong Jung, Young Seok Kim, Ji Hyeon Joo, Won Park, Jong-Hoon Lee, Jin Hee Kim, Won Sup Yoon, Seok-Ho Lee, Keun-Yong Eom, Yong Bae Kim
OBJECTIVE: The aim of this study was to investigate the survival, patterns of failure, and prognostic factors in patients with stage II endometrial carcinoma treated with adjuvant radiotherapy. METHODS: We reviewed the medical records of patients who underwent total hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection followed by adjuvant radiotherapy in 10 participating hospitals of the Korean Radiation Oncology Group. Most patients received adjuvant external beam radiation therapy, with a median dose of 50...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604454/the-significance-of-pretreatment-thrombocytosis-and-its-association-with-neutrophilia-in-patients-with-surgically-treated-endometrial-cancer
#9
Ryoko Takahashi, Seiji Mabuchi, Hiromasa Kuroda, Katsumi Kozasa, Eriko Yokoi, Yuri Matsumoto, Tadashi Kimura
OBJECTIVE: The aim of this study was to investigate the prognostic significance of a pretreatment thrombocytosis and its association with neutrophilia in patients with surgically treated endometrial cancer. METHODS: The baseline characteristics and outcome data of 508 patients with surgically treated endometrial cancer between January 2000 and December 2010 were collected and retrospectively reviewed. The patients were separated into 4 groups according to their platelet counts and the neutrophil counts, and the progression-free and overall survival rates of the 4 groups were compared...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604453/management-of-primary-retroperitoneal-mucinous-tumors-a-retrospective-meta-analysis
#10
Benjamin Wolf, Christin Kunert, Lars-Christian Horn, Jens Einenkel
OBJECTIVE: Primary retroperitoneal mucinous tumors (PRMTs) are rare epithelial neoplasms arising in the retroperitoneal space whose pathogenesis is poorly understood. To date, only single-case reports and small case series on diagnosis and management of these tumors exist. The aim of this first-time meta-analysis was to provide more reliable data to inform the management of PRMTs. METHODS: Database searches were conducted to identify case reports and case series between the years of 1975 and 2015...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604452/utility-and-actual-use-of-european-and-spanish-guidelines-on-the-management-of-endometrial-cancer-among-gynecologic-oncologists-in-spain
#11
Ignacio Zapardiel, Claudia Blancafort, David Cibula, Ibon Jaunarena, Mikel Gorostidi, Antonio Gil-Moreno, Javier De Santiago
OBJECTIVE: The aim of the study was to analyze the current management of endometrial cancer across Spain and to evaluate the use and applicability of the national and international guidelines. MATERIALS AND METHODS: An electronic 30-question survey was distributed among all Spanish Society of Obstetrics and Gynecology-registered specialists dedicated to gynecologic oncology in Spain by e-mail. Data were collected anonymously and analyzed using SPSS program. RESULTS: One hundred forty-five (17...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604451/is-tumor-size-really-important-for-prediction-of-lymphatic-dissemination-in-grade-1-endometrial-carcinoma-with-superficial-myometrial-invasion
#12
Murat Oz, Vakkas Korkmaz, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Zeliha Firat Cuylan, Tayfun Gungor
OBJECTIVES: Selection of patients with endometrioid endometrial cancer (EEC), in whom systematic lymph node dissection (LND) is indicated, is an important part of management to maintain optimal oncological outcomes, while avoiding unnecessary morbidities. According to the current approach, LND is recommended for the patients with International Federation of Gynecology and Obstetrics (FIGO) grade 1 to 2 tumors and a primary tumor diameter (PTD) greater than 2 cm, even with myometrial invasion (MMI) of less than 50%...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604450/low-volume-lymph-node-metastases-in-endometrial-carcinoma
#13
Lani K Clinton, Jordan Kondo, Michael E Carney, Pamela Tauchi-Nishi, Keith Terada, David Shimizu
OBJECTIVE: The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. METHODS: We performed a retrospective review of patients with endometrial carcinoma. RESULTS: Among 350 robotic-assisted hysterectomies for endometrial cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604449/cervical-adenocarcinoma-has-a-poorer-prognosis-and-a-higher-propensity-for-distant-recurrence-than-squamous-cell-carcinoma
#14
Eun Jung Jung, Jung Mi Byun, Young Nam Kim, Kyung Bok Lee, Moon Su Sung, Ki Tae Kim, Dae Hoon Jeong
OBJECTIVE: We aimed to analyze the differences in prognosis and the pattern of recurrence between squamous cell carcinoma (SCC) and adenocarcinoma (ADC) in patients with cervical cancer. METHODS: We retrospectively reviewed the medical records of 969 patients with SCC and 144 patients with ADC who underwent radical hysterectomy and pelvic lymph node dissection at the Busan Paik Hospital between January 1988 and December 2010. RESULTS: Adenocarcinoma was associated with poorer disease-free survival (P = 0...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604448/map2k6-fp-enhances-the-sensitiveness-of-paclitaxel-for-ovarian-cancer-via-inducing-autophagy
#15
Ying Guo, Jin Yuan, Shuqin Yin, Xiaoxia Wang, Rong Shuai, Jiali Kang
BACKGROUND: Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes a major limitation. The key molecule or mechanism associated with paclitaxel resistance in ovarian cancer still remains unclear. Recent studies have revealed an association between autophagy and drug resistance. METHODS: We previously synthesized a MAPK kinase-recombinant fusion protein, MAP2K6-FP, that contains 3 domains: a protein transduction domain TAT, a human ovarian cancer HO8910 cell-specific binding peptide, and a potential antitumor effector domain MKK6(E)...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604447/ovarian-cancer-and-comorbidity-is-poor-survival-explained-by-choice-of-primary-treatment-or-system-delay
#16
Mette Calundann Noer, Cecilie Dyg Sperling, Bent Ottesen, Sofie Leisby Antonsen, Ib Jarle Christensen, Claus Høgdall
OBJECTIVES: Comorbidity influences survival in ovarian cancer, but the causal relations between prognosis and comorbidity are not well characterized. The aim of this study was to investigate the associations between comorbidity, system delay, the choice of primary treatment, and survival in Danish ovarian cancer patients. METHODS: This population-based study was conducted on data from 5317 ovarian cancer patients registered in the Danish Gynecological Cancer Database...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28590950/systematic-review-the-impact-of-cancer-treatment-on-the-gut-and-vaginal-microbiome-in-women-with-a-gynecological-malignancy
#17
Ann Muls, Jervoise Andreyev, Susan Lalondrelle, Alexandra Taylor, Christine Norton, Ailsa Hart
BACKGROUND AND AIM: Worldwide, 1,470,900 women are diagnosed yearly with a gynecological malignancy (21,000 in the UK). Some patients treated with pelvic radiotherapy develop chronic changes in their bowel function. This systematic review summarizes current research on the impact of cancer treatment on the gut and vaginal microbiome in women with a gynecological malignancy. METHODS: The Preferred reporting Items for Systematic Reviews and Meta-analyses guidelines for systematic reviews were used to ensure transparent and complete reporting...
June 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28574933/real-world-management-of-trabectedin-pegylated-liposomal-doxorubicin-in-platinum-sensitive-recurrent-ovarian-cancer-patients-a-national-survey
#18
Gabriella Ferrandina, Giulia Amadio, Ida Paris, Mariagrazia Distefano, Eleonora Palluzzi, Rosa de Vincenzo, Caterina Ricci, Giovanni Scambia
BACKGROUND: Trabectedin (T) plus pegylated liposomal doxorubicin (PLD) is approved for treatment of platinum-sensitive recurrent ovarian cancer (ROC). Despite the recommendations and guidelines, variations in managing T/PLD administration in routine clinical practice cannot be excluded. We aimed at setting up an Italian survey collecting data about management of T/PLD administration in ROC patients. METHODS: We carried out the development of a questionnaire-based survey on routine clinical practice in the management of ROC patients administered T/PLD...
June 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28574932/vascular-endothelial-growth-factor-vegf-polymorphisms-and-serum-vegf-levels-in-women-with-epithelial-ovarian-cancer-benign-tumors-and-healthy-ovaries
#19
Blanca González-Palomares, Pluvio J Coronado Martín, María Luisa Maestro de Las Casas, Silvia Veganzones de Castro, Sara Rafael Fernández, Marta Vidaurreta Lázaro, Virginia De la Orden García, Jose Antonio Vidart Aragon
OBJECTIVE: This study analyzed the relation of 5 single-nucleotide polymorphisms (SNPs) in the VEGF (vascular endothelial growth factor) gene in patients with epithelial ovarian cancer (EOC), compared with patients carrying benign tumors or healthy ovaries. We studied serum VEGF levels and the relation with SNPs and association between VEGF SNPs and haplotypes with progression-free survival (PFS) in patients with cancer. METHODS: The genotyping of VEGF gene polymorphisms (-2578 C/A, -1154 G/A, -460 T/C, +405 G/C, +936 C/T) was performed in DNA isolated from blood samples of 100 women...
June 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28574931/neoadjuvant-weekly-paclitaxel-carboplatin-is-effective-in-stage-i-ii-cervical-cancer
#20
Rawand Salihi, Karin Leunen, Philippe Moerman, Frédéric Amant, Patrick Neven, Ignace Vergote
OBJECTIVE: Neoadjuvant chemotherapy (NACT) followed by surgery in cervical cancer is widely studied with paclitaxel-ifosfamide-cisplatinum 3 weekly (TIP). Although the response rates with TIP are high, the toxicity is substantial. Therefore, this study evaluates dose-dense paclitaxel-carboplatin (TC) as an alternative. METHODS: In this prospective phase 2 study trial, we included 36 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB1 to IIB cervical cancer, who received 9 weeks' NACT dose-dense TC (median weekly dose paclitaxel 60 mg/m, carboplatinum area under the curve 2...
June 1, 2017: International Journal of Gynecological Cancer
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