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International Journal of Gynecological Cancer

Mozhdeh Momtahan, Marjan Hosseini, Minoo Robati, Fatemesadat Najib
OBJECTIVES: The objective of this study was to determine the predictive value of Kanagawa Cancer Center (KCC) scoring system for lymph node metastasis and need for lymphadenectomy in patients with endometrial cancer. METHODS: This cross-sectional study was conducted during a 2-year period in a gynecologic oncology referral center in Southern Iran. We included a total number of 94 patients with endometrial cancer. Preoperative assessment included tumor volume, myometrium invasion, histology, and CA125...
July 10, 2018: International Journal of Gynecological Cancer
Víctor Lago, Belén Martín, Esther Ballesteros, José Miguel Cárdenas-Rebollo, Lucas Minig
OBJECTIVE: This study aimed to identify the correlation between histology tumor grade of the preoperative biopsy using dilatation and curettage (D&C), Pipelle, or hysteroscopy and final surgical specimen in women with endometrioid endometrial cancer. MATERIALS AND METHODS: Patients on whom a preoperative biopsy was performed between 2009 and 2016 were reviewed and cases with apparent early-stage endometrioid endometrial cancer were included in the study. The accuracy of preoperative biopsy performed before hysterectomy using D&C, Pipelle, or hysteroscopy was compared...
July 10, 2018: International Journal of Gynecological Cancer
Zhaoguang Zhang, Zhengang Wang, Rongrong Zhao
OBJECTIVE: This study aimed to investigate the importance of perfusion parameters from the peripheral region in predicting the early response to radiotherapy for advanced cervical carcinoma by using dynamic contrast-enhanced (DCE) perfusion magnetic resonance imaging (MRI). METHODS: One hundred eight patients with advanced cervical carcinoma were enrolled into this study. Dynamic contrast-enhanced perfusion MR examinations were performed for all the patients before radiotherapy...
July 10, 2018: International Journal of Gynecological Cancer
Jie Lee, Chih-Long Chang, Jhen-Bin Lin, Meng-Hao Wu, Fang-Ju Sun, Chieh-Ju Wu, Hung-Chi Tai, Shih-Ming Hsu, Yu-Jen Chen
OBJECTIVE: To evaluate the effects of body mass index (BMI) and weight change during radiotherapy on the development of toxicity in patients with locally advanced cervical cancer (LACC) treated with intensity-modulated radiotherapy (IMRT). METHODS: A total of 245 patients were analyzed after undergoing definitive IMRT treatment between 2004 and 2015 for stage IB2 to stage IVA LACC. The patients were divided into 3 groups: underweight (BMI <18.5 kg/m), normal weight (BMI 18...
July 10, 2018: International Journal of Gynecological Cancer
Alexandre Bricou, Sofiane Bendifallah, Mathilde Daix-Moreux, Lobna Ouldamer, Vincent Lavoue, Amélie Benbara, Cyrille Huchon, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Xavier Carcopino, Cyril Touboul, Emile Daraï, Lionel Carbillon, Marcos Ballester
OBJECTIVE: Endometrial cancer (EC) recurrences are relatively common with no standardized way of describing them. We propose a new classification for them called locoregional, nodal, metastasis, carcinomatosis recurrences (rLMNC). PATIENTS AND METHODS: The data of 1230 women with EC who were initially treated by primary surgery were included in this French multicenter retrospective study. Recurrences were classified based on dissemination pathways: (1) locoregional recurrence (rL); (2) nodal recurrence (rN) for lymphatic pathway; (3) distant organ recurrence (rM) for hematogenous pathway; and (4) carcinomatosis recurrence (rC) for peritoneal pathway...
July 10, 2018: International Journal of Gynecological Cancer
Lukas Dostalek, Elisabeth Åvall-Lundqvist, Carien L Creutzberg, Dina Kurdiani, Jordi Ponce, Iva Dostalkova, David Cibula
OBJECTIVE: The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages. MATERIALS AND METHODS: A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance...
June 28, 2018: International Journal of Gynecological Cancer
Meirav Schmidt, Yakir Segev, Rotem Sadeh, Erica Suzan, Ido Feferkorn, Anis Kaldawy, Gilit Kligun, Ofer Lavie
OBJECTIVES: Uterine papillary serous carcinoma (UPSC) is a highly aggressive subtype of endometrial carcinoma. Histopathologically, it resembles the pattern of serous papillary carcinoma of the ovary. Cancer antigen 125 (CA-125) is the most widely used biomarker in epithelial ovarian carcinoma. Its use in UPSC evaluation has yet to be determined. The purpose of this study was to investigate the significance of preoperative serum CA-125 as a prognostic factor in patients with UPSC. METHODS: The study cohort included all women with UPSC operated in our institution between January 2002 and June 2016...
June 28, 2018: International Journal of Gynecological Cancer
Víctor Lago, Blas Flor, Luis Matute, Pablo Padilla-Iserte, Alvaro García-Granero, Marco Bustamante, Santiago Domingo
OBJECTIVE: Diverting ileostomy (DI) has been proposed to reduce the incidence and consequences anastomotic leakage after bowel resection. In colorectal cancer treatment, ghost ileostomy (GI) has been proposed as an alternative to DI. Our objective was to report the results of GI associated with colorectal resection in the treatment of ovarian cancer. MATERIALS AND METHODS: This is an observational pilot study performed in a single institution. The main objective sought was to report the results of GI associated with colorectal resection in the treatment of ovarian cancer: 26 patients were included...
June 19, 2018: International Journal of Gynecological Cancer
Linn Woelber, Simon A Joosse, Donata Grimm, Sabrina Mathey, Sven Mahner, Eike Burandt, Susanne Klutmann, Barbara Schmalfeldt, Katharina Prieske
OBJECTIVE: Sentinel node biopsy (SNB) has become standard of care in early stage vulvar cancer. As the correlation of isotope count with the presence of metastases remains unclear, often several active nodes are excised per groin. This can result in increased morbidity in node-negative disease despite of SNB. In the current analysis, we assess whether resection of the hottest node could be sufficient to detect sentinel lymph node (SLN) metastasis. METHODS: Patients with primary vulvar cancer receiving an SNB with radioactive tracer at the University Medical Center Hamburg-Eppendorf between 2008 and 2015 were evaluated...
June 19, 2018: International Journal of Gynecological Cancer
Snežana M Bošnjak, Ljiljana Stamatovic, Maria Elisa Borroni, Giada Rizzi, Karin Jordan
OBJECTIVE: Patients with gynecological cancers are at high risk for chemotherapy-induced nausea and vomiting (CINV) after platinum-based chemotherapy (CT). NEPA (300-mg netupitant, 0.50-mg palonosetron) is the first oral fixed-combination antiemetic. Pivotal trials demonstrated the superiority of oral NEPA over intravenous palonosetron in preventing CINV after highly emetogenic (anthracycline-cyclophosphamide-based [AC] and cisplatin-based [non-AC]) CT. This post hoc subset analysis considered patients with gynecological cancer receiving cisplatin- or carboplatin-based CT from 1 pivotal trial and from 1 multicycle safety trial to evaluate the efficacy of oral NEPA in preventing CINV...
June 19, 2018: International Journal of Gynecological Cancer
Mercy Nkuba Nassali, Melese Tadele, Robert Michael Nkuba, Jamieson Modimowame, Iwuh Enyeribe, Edwin Katse
OBJECTIVES: The aim of this study was to determine predictors of locally advanced disease at presentation and clinical outcomes among cervical cancer patients in Botswana to inform interventional strategies. METHODS: Retrospective review of 149 medical records of new cervical cancer patients was conducted between August 2016 and February 2017 at the Princess Marina Hospital. Data collected included sociodemographics, presenting symptoms, stage of disease, comorbidities, interventions, and clinical outcomes...
May 23, 2018: International Journal of Gynecological Cancer
Marlene Kranawetter, Sebastian Röhrich, Leonhard Müllauer, Helena Obermair, Alexander Reinthaller, Christoph Grimm, Alina Sturdza, Wolfgang J Köstler, Stephan Polterauer
OBJECTIVES: Recent data support the use of pembrolizumab in cervical cancer. The aim of this study was to investigate pembrolizumab in heavily pretreated patients with recurrent cervical cancer. METHODS: Data from consecutive patients treated with pembrolizumab at a single academic institution were assessed. Programmed cell death ligand 1 (PD-L1) status and microsatellite instability were assessed from tumor samples. Irrespective of PD-L1 expression status, pembrolizumab was administered at fixed dose of 200 mg intravenously every 3 weeks...
May 22, 2018: International Journal of Gynecological Cancer
Anastasios Tranoulis, Alexandros Laios, George Theophilou, Konstantinos Bramis, Sean Kehoe
OBJECTIVE: Inguinofemoral lymphadenectomy (IFL) is included in the standard surgical management of early-stage vulval cancer (VC) but is often accompanied by surgical complications. Efforts have been made to limit the postoperative morbidity by adopting more conservative IFL techniques without compromising the surgical outcomes. Saphenous vein (SV) preservation during IFL for VC appears to reduce the incidence of postoperative complications including lymphedema. To ascertain the efficacy of SV preservation, we aimed to revisit the impact of SV preservation on short-term per groin complications by updating on a previous meta-analysis to further guide current clinical practice...
May 22, 2018: International Journal of Gynecological Cancer
Jun Zhu, Long Jiang, Hao Wen, Rui Bi, Xiaohua Wu, Xingzhu Ju
BACKGROUND: There are no effective biomarkers for surveillance in ovarian clear cell carcinoma (OCCC), and the value of carbohydrate antigen 125 (CA-125) is limited. We sought to determine the value of both carbohydrate antigen 19-9 (CA19-9) and CA-125 levels postoperatively on the prognosis for OCCC. METHODS: A total of 130 patients with OCCC who were consecutively treated by cytoreduction at Fudan University Shanghai Cancer Center were reviewed retrospectively...
May 18, 2018: International Journal of Gynecological Cancer
Ingvild Vistad, Milada Cvancarova, Guro Lindviksmoen Astrup, Tone Rustøen, Astrid H Liavaag
OBJECTIVES: In this longitudinal study, we investigated occurrence of multiple symptoms during chemotherapy in patients with ovarian cancer. We also evaluated whether self-rated physical functioning, selected demographic, and clinical variables were associated with symptom burden over time. METHODS AND MATERIALS: In total, 82 patients provided longitudinal data (4 time points) by completing questionnaires including the Memorial Symptom Assessment Scale, the Karnofsky Performance Status Scale, and the Self-Administered Comorbidity Questionnaire...
May 18, 2018: International Journal of Gynecological Cancer
Peter Widschwendter, Emanuel Bauer, Nikolaus De Gregorio, Inga Bekes, Wolfgang Janni, Christoph Scholz, Thomas W P Friedl
OBJECTIVE: The requirement for and extent of lymphadenectomy in endometrial cancer is still controversial. Clinicopathological prognostic factors could be helpful to predict lymph node involvement and avoid therefore unnecessary lymphadenectomy. The aim of this study was to investigate which factors can predict lymph node involvement and how lymph node metastases are distributed in the pelvic and para-aortic regions. METHODS: This retrospective analysis was performed by analyzing data from patients with endometrial cancer treated with standard surgery and lymphadenectomy at the Department of Gynecology and Obstetrics of the University Hospital Ulm in 2000 to 2013...
May 11, 2018: International Journal of Gynecological Cancer
Bryn Lander, Elizabeth Wilcox, Jessica N McAlpine, Sarah J Finlayson, David G Huntsman, Dianne Miller, Gillian E Hanley
OBJECTIVE: The aim of the study was to explore the factors that contributed to the adoption of opportunistic salpingectomies (removal of fallopian at the time of hysterectomy or in lieu of tubal ligation) by gynecologic surgeons in British Columbia (where a knowledge translation initiative took place) and in Ontario (a comparator where no knowledge translation initiative took place). We aimed to understand why the knowledge translation initiative undertaken by OVCARE in British Columbia resulted in such a dramatic uptake in opportunistic salpingectomy...
May 11, 2018: International Journal of Gynecological Cancer
Jui-Kun Chiang, Chun-Shuo Hsu, Chih-Wen Lin, Yee-Hsin Kao
OBJECTIVE: To date, few studies have examined end-of-life (EOL) care and healthcare costs for patients with ovarian cancer. We evaluated the effects of hospice care on the quality of EOL care and healthcare costs for patients with ovarian cancer in the final month of life. MATERIALS AND METHODS: We conducted a population-based study and analyzed data from Taiwan's Longitudinal Health Insurance Database, which contains claims information for medical records of patients, healthcare costs, and insurance system exit dates: our proxy for death between 1997 and 2011...
May 11, 2018: International Journal of Gynecological Cancer
Katherine LaVigne, David M Hyman, Qin C Zhou, Alexia Iasonos, William P Tew, Carol Aghajanian, Vicky Makker, Martee L Hensley, Jason Konner, Rachel N Grisham, Nicholas Cangemi, Krysten Soldan, David R Spriggs, Paul J Sabbatini, Roisin E OʼCearbhaill
OBJECTIVE: Hypersensitivity with repeated exposure to platinum agents is common and can preclude continued treatment, even in patients with disease that remains platinum sensitive. We sought to compare the effects of prophylactic, extended carboplatin infusion versus standard infusion on the rate of carboplatin hypersensitivity reactions (HSRs) in women with recurrent ovarian cancer. METHODS: This was a single-institution, randomized, nonblinded trial comparing a graded, 3-hour extended infusion of carboplatin with a standard 30-minute infusion in patients with recurrent ovarian cancer who were enrolled from January 2011 to April 2015...
May 4, 2018: International Journal of Gynecological Cancer
Claire Thompson, Waseem Kamran, Lucy Dockrell, Srwa Khalid, Meena Kumari, Nadia Ibrahim, John OʼLeary, Lucy Norris, Max Petzold, Sharon OʼToole, Noreen Gleeson
OBJECTIVE: The aim of this study was to examine the clearance of serum human epididymis protein 4 (HE4) in the immediate postoperative period in patients undergoing maximal effort cytoreductive surgery for ovarian carcinoma. METHODS: The study was performed at a tertiary gynecologic oncology center. The surgery was performed by accredited gynecological oncologists. RESULTS: Preoperative and serial postoperative venous blood samples at 4, 8, 24, 48, 72, 96, and 120 hours were taken from 10 sequential patients...
May 4, 2018: International Journal of Gynecological Cancer
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