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Nutrition, Metabolism, and Cardiovascular Diseases: NMCD

Q He, X Liu, Y Zhong, S S Xu, Z M Zhang, L L Tang, L Y Zhang, L Z Du
BACKGROUND AND AIMS: Intrauterine growth restriction (IUGR) is a major risk factor for perinatal morbidity and mortality, leading to long-term adverse cardiovascular outcomes. The present study aimed to investigate the potential mechanisms in IUGR-associated vascular endothelial dysfunction. METHODS AND RESULTS: Human umbilical vein endothelial cells (HUVECs) were derived from IUGR or normal newborns. We found that the proliferation of IUGR-derived HUVECs was accelerated compared to those from normal subjects...
September 22, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
P Mirmiran, M Carlström, Z Bahadoran, F Azizi
BACKGROUND AND AIM: Here, we examined the potential effect of coffee consumption and total caffeine intake on the occurrence of pre-diabetes and T2D, in a population with low coffee consumption. METHODS AND RESULTS: Adults men and women, aged 20-70 years, were followed for a median of 5.8 y. Dietary intakes of coffee and caffeine were estimated using a 168-food items validate semi-quantitative food frequency questionnaire, at baseline. Cox proportional hazards regression models, adjusted for potential cofounders, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between coffee and caffeine intakes and incidence of pre-diabetes and T2D...
September 12, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
K S Flannagan, M Ramírez-Zea, A V Roman, A K Das, E Villamor
BACKGROUND AND AIMS: Polyunsaturated fatty acids (PUFA) may play a role in the etiology of the metabolic syndrome (MetS). The aim of the study was to examine the associations of adipose tissue PUFA biomarkers with MetS among parents and children in Mesoamerica. METHOD AND RESULTS: We conducted a cross-sectional study among 468 parents and 201 children aged 7-12 y from the capital cities of Guatemala, El Salvador, the Dominican Republic, Honduras, Nicaragua, Panama, Costa Rica, and Belize, and Tuxtla Gutiérrez in Mexico...
September 6, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
P Di Bonito, E Miraglia Del Giudice, C Chiesa, M R Licenziati, M Manco, F Franco, G Tornese, M G Baroni, A Morandi, C Maffeis, L Pacifico, G Valerio
BACKGROUND AND AIMS: We aimed to evaluate whether the metabolically healthy obese (MHO) phenotype was associated with hepatic steatosis (HS) or left ventricular hypertrophy (LVH) in young people with overweight (OW), obesity (OB) and morbid obesity (MOB) and whether the prevalence of these comorbidities was affected by OB severity. METHODS AND RESULTS: An abdominal ultrasound was performed in 1769 children and adolescents, mean age 10.6 years (range 5-18) with MHO phenotype, defined as the absence of traditional cardiometabolic risk factors, in order to identify HS...
September 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
L Zanoli, A Di Pino, V Terranova, S Di Marca, M Pisano, R Di Quattro, V Ferrara, R Scicali, A M Rabuazzo, P Fatuzzo, P Castellino, S Piro, F Purrello, L Malatino
BACKGROUND AND AIMS: Metabolic syndrome (MetS) is currently considered to raise the risk for type 2 diabetes and cardiovascular events. It has been suggested that part of this risk excess may be due to a cluster of additional factors associated with MetS. We aimed to investigate the role of inflammation on the ventricular-vascular coupling in patients with MetS. METHODS AND RESULTS: We enrolled a total of 227 hypertensive patients (106 with MetS and 121 without MetS) matched for age and gender...
August 23, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
T Jespersen, N Kruse, T Mehta, M Kuwabara, L Noureddine, D Jalal
AIMS: To examine the association between wine consumption and the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD). DATA SYNTHESIS: We performed a cross-sectional logistic regression analysis of National Health and Nutrition Examination Survey (NHANES) in participants 21 years of age or older from 2003 to 2006 in a large representative study of the U.S. POPULATION: Wine consumption was categorized as none (0 glass per day), light (<1 glass per day), or moderate (≥1 glasses per day)...
August 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
D Aune, S Schlesinger, M Neuenschwander, T Feng, I Janszky, T Norat, E Riboli
BACKGROUND AND AIM: The strength of the association between diabetes and risk of heart failure has differed between previous studies and the available studies have not been summarized in a meta-analysis. We therefore quantified the association between diabetes and blood glucose and heart failure in a systematic review and meta-analysis. METHODS AND RESULTS: PubMed and Embase databases were searched up to May 3rd 2018. Prospective studies on diabetes mellitus or blood glucose and heart failure risk were included...
November 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
E R Miranda, K N Z Fuller, R K Perkins, C M Kroeger, J F Trepanowski, K A Varady, J M Haus
BACKGROUND AND AIMS: The receptor for advanced glycation end products (RAGE) is implicated in obesogenesis. Conversely, soluble RAGE (sRAGE) competitively inhibits RAGE. Our aim was to determine the effects of weight-loss via alternate day fasting (ADF) on sRAGE isoforms and evaluate potential relationships with body composition. METHODS AND RESULTS: 42 obese participants were randomized to control (CON) or ADF. For 24 weeks, the ADF group consumed 25% or 125% of their caloric requirements on alternating days while the CON group did not change their diet...
November 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
D Luan, D Wang, H Campos, A Baylin
BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R Rosário, R Santos, L Lopes, C Agostinis-Sobrinho, C Moreira, J Mota, S Póvoas, A Oliveira, P Padrão, P Moreira, S Abreu
BACKGROUND AND AIMS: The associations between fruit and vegetable consumption and high blood pressure among adults are well studied. Nonetheless, data on the influence of a low consumption of fruit and vegetables on cardiovascular disease risk, particularly blood pressure, among healthy adolescents are scarce. Therefore, we aim to analyse the associations between fruit and/or vegetable intake and blood pressure over a two-year period in healthy adolescents. METHODS AND RESULTS: As part of a cohort, 606 adolescents from the LabMed Physical Activity study were evaluated in 2011 (baseline) and 2013 (follow-up)...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R Y Xu, Y Q Zhou, X M Zhang, Y P Wan, X Gao
BACKGROUND AND AIMS: We prospectively examined the association between three adiposity indices, including body mass index (BMI), waist circumference (WC), and percentage of body fat (PBF), and risk of hypertension in normal-weight Chinese children. METHODS AND RESULTS: The current study included 1526 (713 boys and 813 girls) normal-weight Chinese children (age 6-14 years old), who were free of hypertension at baseline (2014). Heights, body weight, WC, and PBF (estimated by bioelectrical impedance analysis) were measured at the baseline...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
G Mena-Sánchez, N Babio, M Á Martínez-González, D Corella, H Schröder, J Vioque, D Romaguera, J A Martínez, J Lopez-Miranda, R Estruch, J Wärnberg, A Bueno-Cavanillas, L Serra-Majem, J A Tur, F Arós, F J Tinahones, V M Sánchez, J Lapetra, X Pintó, J Vidal, C Vázquez, J M Ordovás, M Delgado-Rodriguez, P Matía-Martín, J Basora, P Buil-Cosiales, R Fernandez-Carrion, M Fitó, J Salas-Salvadó
BACKGROUND AND AIMS: Fermented dairy products have been associated with a better diet quality and cardio-metabolic profile. However, in Mediterranean populations, these associations have not been well characterized. The aim of this study was to assess the diet quality and the associations between the consumption of total fermented dairy products and their subtypes and the prevalence of Metabolic Syndrome (MetS) components in a Mediterranean population at high cardiovascular risk. METHODS AND RESULTS: Baseline cross-sectional analyses were conducted on 6,572 men and women (mean age: 65 years) with overweight or obesity and MetS recruited into the PREDIMED-Plus cohort...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H Halland, M T Lønnebakken, N Pristaj, S Saeed, H Midtbø, E Einarsen, E Gerdts
BACKGROUND AND AIMS: Subclinical cardiac disease, like abnormal left ventricular (LV) geometry or left atrial (LA) dilatation, is common in obesity. Less is known about sex differences in the prevalence and type of subclinical cardiac disease in obesity. METHODS AND RESULTS: Clinical and echocardiographic data from 581 women and men without established cardiovascular disease and body mass index (BMI) > 27.0 kg/m2 participating in the FAT associated CardiOvasculaR dysfunction (FATCOR) study was analyzed...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
E S Eshak, A E Arafa
BACKGROUND AND AIM: Thiamine, also known as vitamin B1, functions as a cofactor in the metabolism of carbohydrates and amino acids. Thiamine deficiency has been suggested to be associated with many cardiovascular diseases (CVDs) and risk factors including type 1 and type 2 diabetes (T1D and T2D, respectively), obesity, chronic vascular inflammation, dyslipidemia, heart failure (HF), myocardial infarction (MI) and conduction defects, and depression. The aim of this review was to explore the evidence of thiamine deficiency among subjects with CVDs or risk factors, illustrate the theories explaining the thiamine-CVDs associations, and describe the effect of thiamine supplementation...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Jia, S Xu, Y Xing, W Zhang, X Yu, Y Zhao, J Ming, Q Ji
BACKGROUND AND AIMS: Several studies have reported increased cardiovascular risks in normal weight obesity (NWO) populations. We aimed to investigate the prevalence of NWO and its relationships with cardiometabolic risks in Chinese patients. METHODS AND RESULTS: The data were from the 2007-2008 China National Diabetes and Metabolic Disorders Study. The body fat (BF) was measured using the biological impedance method. NWO was defined as a normal BMI (18.5-23.9 kg/m2 ) but with excess BF% (BF% ≥ 24% for men and ≥33% for women)...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Z Wang, A M Siega-Riz, P Gordon-Larsen, J Cai, L S Adair, B Zhang, B M Popkin
AIM: We examined the association between diet quality and diabetes and major cardiometabolic risks among adults in China. METHODS AND RESULTS: We developed the China Dietary Guideline Index (CDGI) based on the 2007 Chinese dietary guidelines and tailored the Alternate Healthy Eating Index 2010 (which we call the tAHEI) to assess diet quality. Our analysis linked the dietary intake and covariates measured in 2006 with CM risk factors measured in 2009. We used diet data the longitudinal China Health and Nutrition Survey 2006 collected in 3 consecutive 24-h recalls from 4440 adults aged 18 to 65 to calculate both the tAHEI and the CDGI scores...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Fingeret, P Marques-Vidal, P Vollenweider
BACKGROUND AND AIMS: Metabolically healthy obese (MHO) individuals are devoid of many metabolic abnormalities, but how this condition is maintained over time remains debated. We assessed the prevalence of MHO over time and the incidence of hypertension (HTN), dyslipidemia, and type 2 diabetes mellitus (T2DM) in MHO as compared with metabolically healthy non obese (MHNO). METHODS AND RESULTS: Prospective, population-based study including 3038 participants (49.9 ± 9...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
C Mele, M A Tagliaferri, G Saraceno, S Mai, R Vietti, M Zavattaro, G Aimaretti, M Scacchi, P Marzullo
BACKGROUND AND AIMS: Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. METHODS AND RESULTS: In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Cabral, J Araújo, C Lopes, E Ramos
BACKGROUND AND AIMS: Diet comprises factors with anti and pro-inflammatory potential that can contribute to modulate obesity-induced inflammation. We aimed to assess the association between food intake and high-sensitivity C-reactive protein (hsCRP) levels in adolescents. METHODS AND RESULTS: A cross-sectional analysis of 991 adolescents aged 13 years old was conducted as part of the EPITeen cohort, Porto, Portugal. Food intake was assessed by a food frequency questionnaire and thirteen food groups were defined...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H-W Zhang, X Zhao, Y-L Guo, Y Gao, C-G Zhu, N-Q Wu, J-J Li
BACKGROUND AND AIMS: The role of lipoprotein (a) [Lp(a)] in coronary artery diseases (CAD) with special clinical background such as type 2 diabetes mellitus (T2DM) has not been fully determined. The aim of the present study was to investigate the relation of Lp(a) to type 2 diabetic patients with or without CAD. METHODS AND RESULTS: A total of 2040 consecutive patients with T2DM who received selective coronary angiography (CAG) due to angina-like chest pain were enrolled...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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