Read by QxMD icon Read

Nutrition, Metabolism, and Cardiovascular Diseases: NMCD

A Zullo, E Simone, M Grimaldi, M Gagliardi, L Zullo, M R Matarazzo, F P Mancini
BACKGROUND AND AIM: Over the last decades advances in understanding the molecular bases of the close relationship between nutrition, metabolism, and diseases have been impressive. However, there are always novel frontiers coming up and epigenetics is one of these. Sirtuins, are pivotal factors in the control of metabolic pathways according to nutrient availability. In the present study we evaluated the effect of nutrient deprivation on expression, DNA methylation and chromatin status of the sirtuin genes...
February 13, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Mattina, D Rosenbaum, R Bittar, D Bonnefont-Rousselot, D Noto, M Averna, E Bruckert, P Giral
BACKGROUND AND AIM: Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) plays a key role in atherosclerosis development. It is considered a marker of increased risk of cardiovascular disease (CVD) and plaque vulnerability. Familial hypercholesterolemia (FH) is a genetic disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol and a higher prevalence of early CVD. Our aim was to evaluate the differences in Lp-PLA2 activity in a population of hypercholesterolemic patients with and without definite FH...
February 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F Carbone, E Nulli Migliola, A Bonaventura, A Vecchié, S De Vuono, M A Ricci, G Vaudo, M Boni, F Dallegri, F Montecucco, G Lupattelli
BACKGROUND & AIMS: Gender-related differences represent an emerging investigation field to better understand obesity heterogeneity and paradoxically associated cardiovascular (CV) risk. Here, we investigated if high-sensitivity C-reactive protein (hs-CRP) might differently affect adiposity and predict the clinical response to bariatric surgery in obese males and females. METHODS AND RESULTS: In 110 morbidly obese patients undergoing laparoscopic sleeve gastrectomy, hs-CRP as well as anthropometric assessment of adiposity, completed by electric bioimpedance and ultrasonography quantification of visceral fat area (VFA), were measured before and one year after surgery...
February 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Hoyer, T Tönnies, R Brinks
No abstract text is available yet for this article.
February 1, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
B Stutz, A J Ahola, V Harjutsalo, C Forsblom, P-H Groop
BACKGROUND AND AIMS: In the general population, habitual coffee consumption is inversely associated with the metabolic syndrome, a syndrome that is rather common also in patients with type 1 diabetes. However, whether coffee intake is beneficially related to the metabolic syndrome also in type 1 diabetes, is not known. We, therefore, studied the potential association between coffee consumption and the metabolic syndrome in a large population of individuals with type 1 diabetes. Furthermore, we investigated whether coffee consumption is associated with insulin resistance (estimated glucose disposal rate, eGDR), kidney function (estimated glomerular filtration rate, eGFR), and low-grade chronic inflammation (high-sensitivity C-reactive protein, hsCRP)...
February 1, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Shiyovich, Y Plakht, H Gilutz
BACKGROUND AND AIM: Serum calcium levels (sCa) were reported to be associated with cardiovascular risk factors, incidence of coronary artery disease and acute myocardial infarction (AMI). The current study evaluated the association between sCa and in-hospital mortality among AMI patients. METHODS AND RESULTS: Patients admitted in a tertiary medical center for AMI throughout 2002-2012 were analyzed. For each patient, mean sCa, corrected to albumin, was calculated and categorized to seven equally-sized groups: <8...
February 1, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
G Zoppini, U Fedeli, E Schievano, M Dauriz, G Targher, E Bonora, M C Corti
BACKGROUND AND AIMS: To investigate the risk of mortality from infections by comparing the underlying causes of death versus the multiple causes of death in known diabetic subjects living in the Veneto region of Northern Italy. METHODS AND RESULTS: A total of 185,341 subjects with diabetes aged 30-89 years were identified in the year 2010, and causes of death were assessed from 2010 to 2015. Standardized Mortality Ratios (SMRs) with 95% confidence intervals (CIs) were computed with regional mortality rates as reference...
January 31, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F U C E Jung, C Luck-Sikorski, M Krüger, C Wiacek, P G Braun, S Engeli, S G Riedel-Heller
BACKGROUND AND AIM: Cardiovascular disease (CVD) is likely to increase in incidence. Foods with cardioprotective functions, e.g. specific functional food, could reduce CVD risk factors and hence CVD incidence. Little is known about industrially modified foods with cardioprotective functions. METHODS AND RESULTS: In a large German sample (n = 1007), attitudes of consumers in Germany towards industrially produced cardioprotective food were assessed using Cluster analyses...
January 31, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
E Verduci, F Moretti, G Bassanini, G Banderali, V Rovelli, M C Casiraghi, G Morace, F Borgo, E Borghi
BACKGROUND AND AIMS: Phenylalanine (Phe) restricted diet, combined with Phe-free l-amino acid supplementation, is the mainstay of treatment for phenylketonuria (PKU). Being the diet a key factor modulating gut microbiota composition, the aim of the present paper was to compare dietary intakes, gut microbiota biodiversity and short chain fatty acids (SCFAs) production in children with PKU, on low-Phe diet, and in children with mild hyperphenylalaninemia (MHP), on unrestricted diet. METHODS AND RESULTS: We enrolled 21 PKU and 21 MHP children matched for gender, age and body mass index z-score...
January 31, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F Boscari, S Galasso, G Acciaroli, A Facchinetti, M C Marescotti, A Avogaro, D Bruttomesso
No abstract text is available yet for this article.
January 31, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M V Lind, L Lauritzen, H Vestergaard, T Hansen, O Pedersen, M Kristensen, A B Ross
BACKGROUND AND AIMS: Alterations to one-carbon metabolism, especially elevated plasma homocysteine (Hcy), have been suggested to be both a cause and a consequence of the metabolic syndrome (MS). A deeper understanding of the role of other one-carbon metabolites in MS, including s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), and the methylation capacity index (SAM:SAH ratio) is required. METHODS AND RESULTS: 118 men and women with MS-risk factors were included in this cross-sectional study and cardiometabolic outcomes along with markers of one-carbon metabolism, including fasting plasma SAM, SAH, Hcy and vitamin B12 concentrations, were analysed...
January 31, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
L Iacoviello, M Bonaccio, G Cairella, M V Catani, S Costanzo, L D'Elia, R Giacco, D Rendina, P Sabino, I Savini, P Strazzullo
BACKGROUND AND AIMS: To systematically review the latest evidence on established and emerging nutrition-related risk factors for incidence of and mortality from total, ischemic and haemorrhagic strokes. The present review was conducted in the framework of the work carried out through 2015 and 2016 for the preparation of the Italian Guidelines for the Prevention and Treatment of Stroke, 8th Edition, by ISO-SPREAD (Italian Stroke Organization and the Stroke Prevention and Educational Awareness Diffusion)...
January 17, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
S Coiro, E Carluccio, P Biagioli, G Alunni, A Murrone, A D'Antonio, C Zuchi, A Mengoni, N Girerd, C Borghi, G Ambrosio
BACKGROUND AND AIMS: Elevated serum uric acid (sUA) concentrations have been associated with worse prognosis in heart failure (HF) but little is known about elderly patients. We aimed to assess long-term additive prognostic value of sUA in elderly patients hospitalized for HF. METHODS AND RESULTS: Clinical and echocardiographic characteristics of 310 consecutive elderly patients hospitalized for HF were collected. During index period, 206 had sUA concentrations available, which were obtained within 24 h prior to discharge; 10 patients were lost to follow-up, leaving 196 patients available...
January 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Guevara-Cruz, J M Vargas-Morales, A L Méndez-García, A M López-Barradas, O Granados-Portillo, G Ordaz-Nava, A K Rocha-Viggiano, C A Gutierrez-Leyte, E Medina-Cerda, J L Rosado, J C Morales, N Torres, A R Tovar, L G Noriega
BACKGROUND AND AIMS: An increase in plasma branched-chain amino acids is associated with a higher risk of developing type 2 diabetes and cardiovascular diseases. However, little is known about the basal plasma amino acid concentrations in young adults. Our aim was to determine the plasma amino acid profiles of young adults and to evaluate how these profiles were modified by sex, body mass index (BMI) and insulin resistance (IR). METHODS AND RESULTS: We performed a transversal study with 608 Mexican young adults aged 19...
January 10, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Dauriz, E Bacchi, L Boselli, L Santi, C Negri, M Trombetta, R C Bonadonna, E Bonora, P Moghetti
BACKGROUND AND AIM: Lifestyle is considered a major determinant of risk of type 2 diabetes (T2D). We investigated whether daily physical activity (DPA) is associated with beta-cell function (BF) and/or insulin sensitivity (IS) in patients with T2D at the time of diagnosis. METHODS AND RESULTS: In 41 subjects enrolled in the Verona Newly-Diagnosed Type 2 Diabetes Study we assessed: (1) IS, by euglycaemic insulin clamp; (2) BF, estimated by prolonged-OGTT minimal modeling and expressed as derivative and proportional control; (3) DPA and energy expenditure (EE), assessed over 48-h monitoring by a validated wearable armband system...
January 9, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F Bellavere, V Cacciatori, E Bacchi, M L Gemma, D Raimondo, C Negri, K Thomaseth, M Muggeo, E Bonora, P Moghetti
BACKGROUND AND AIMS: Both aerobic (AER) and resistance (RES) training improve metabolic control in patients with type 2 diabetes (T2DM). However, information on the effects of these training modalities on cardiovascular autonomic control is limited. Our aim was to compare the effects of AER and RES training on cardiovascular autonomic function in these subjects. METHODS AND RESULTS: Cardiovascular autonomic control was assessed by Power Spectral Analysis (PSA) of Heart Rate Variability (HRV) and baroreceptors function indexes in 30 subjects with T2DM, randomly assigned to aerobic or resistance training for 4 months...
January 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R Obeid, U Hübner, M Bodis, S Graeber, J Geisel
BACKGROUND AND AIM: B-vitamins may influence DNA methylation. We studied the effects of vitamin D + Ca + B versus D + Ca on epigenetic age markers and biological age. METHODS AND RESULTS: Participants (mean ± SD of age = 68.4 ± 10.1 years) were randomized to receive 1200 IE vitamin D3 plus 800 mg Ca-carbonate alone (n = 31) or with 0.5 mg B9, 50 mg B6, and 0.5 mg B12 (n = 32). The CpG methylation of 3 genes (ASPA, ITGA2B, and PDE4C) and the changes in methylation were compared between the groups after 1 year...
December 29, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
K Yang, Y Li, Z Mao, X Liu, H Zhang, R Liu, Y Xue, R Tu, X Liu, X Zhang, W Li, C Wang
BACKGROUND AND AIMS: The purpose of this study was to explore the association between spicy flavor, spicy food frequency, and general obesity in Chinese rural adults. METHODS AND RESULTS: A total of 15,683 subjects (5907 males, 9776 females) aged 35-74 years from the RuralDiab Study were recruited for this cross-sectional study. Analysis of covariance was used to determine the differences of participant characteristics across body mass index (BMI) categories. Logistic regression yielded adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for obesity associated with the level of spicy flavor and frequency of spicy food intake...
December 27, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A V Mattioli, M Ballerini Puviani
No abstract text is available yet for this article.
April 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M R P Markus, T Ittermann, S E Baumeister, C Huth, B Thorand, C Herder, M Roden, U Siewert-Markus, W Rathmann, W Koenig, M Dörr, H Völzke, S Schipf, C Meisinger
BACKGROUND AND AIMS: We investigated the associations of serum fasting (FG) and 2-h postload (2HG) glucose from an oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR) with urinary albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR). METHODS AND RESULTS: We performed cross-sectional analyses of 2713 subjects (1429 women; 52.7%) without known type 2 diabetes, aged 31-82 years, from the KORA (Cooperative Health Research in the Augsburg Region) F4-Study...
March 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"