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Nutrition, Metabolism, and Cardiovascular Diseases: NMCD

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https://www.readbyqxmd.com/read/29122443/identification-of-serum-metabolites-associated-with-obesity-and-traditional-risk-factors-for-metabolic-disease-in-chinese-adults
#1
S M Wang, R Y Yang, M Wang, F S Ji, H X Li, Y M Tang, W X Chen, J Dong
BACKGROUND AND AIMS: Obesity is a major worldwide health problem and is often associated with many metabolic diseases. Levels of several serum-specific metabolites may be altered in patients with these metabolic diseases. We aimed to investigate the associations of serum metabolite levels with obesity and traditional risk factors for metabolic disease in Chinese individuals. METHODS AND RESULTS: Six-hundred Chinese individuals undergoing annual physical exams were recruited and categorized into overweight/obese and control groups (1:1 ratio)...
October 3, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29122442/serum-fetuin-a-levels-in-obese-children-with-biopsy-proven-nonalcoholic-fatty-liver-disease
#2
V Pampanini, E Inzaghi, D Germani, A Alterio, A Puglianiello, A Alisi, V Nobili, S Cianfarani
BACKGROUND AND AIMS: Fetuin-A has been proposed as a marker of liver damage in adults with obesity-related NAFLD. The aim of this study was to test serum fetuin-A concentrations in obese children with NAFLD diagnosed either by ultrasonography or by liver biopsy and to determine its applicability as predictive tool in pediatric NAFLD. METHODS AND RESULTS: Metabolic parameters and fetuin-A levels were investigated in 81 obese children with NAFLD diagnosed by biopsy, 79 obese children with NAFLD defined by liver ultrasonography and 23 lean subjects...
October 3, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29074382/relationship-between-mediterranean-diet-and-asymptomatic-peripheral-arterial-disease-in-a-population-of-pre-menopausal-women
#3
A V Mattioli, F Coppi, M Migaldi, P Scicchitano, M M Ciccone, A Farinetti
BACKGROUND AND AIMS: The Mediterranean Diet (MedD) is considered a very healthy diet useful in the prevention of cardiovascular disease. The present study aims to evaluate adherence to MedD in unselected premenopausal women and its relation with ankle-brachial index (ABI), an index of preclinical atherosclerosis. METHODS AND RESULTS: A group of 425 patients (age range 45-54 years) was investigated. They were enrolled only if they were asymptomatic for cardiovascular disease...
October 3, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29111079/phytosterol-enriched-milk-lowers-ldl-cholesterol-levels-in-brazilian-children-and-adolescents-double-blind-cross-over-trial
#4
S A Ribas, R Sichieri, A S B Moreira, D O Souza, C T F Cabral, D T Gianinni, D B Cunha
BACKGROUND AND AIMS: Despite evidence of the lipid-lowering effect of plant sterols among adults with hypercholesterolemia, data regarding phytosterol use in children are limited. In this paper, we examined the effects of daily consumption of a phytosterol-enriched milk compound on the lipid profiles of Brazilian children and adolescents with dyslipidemia. METHODS AND RESULTS: This was a randomized, double blind, crossover clinical trial. Twenty eight dyslipidemics outpatients (aged 6-9 years) from an University Hospital were randomly allocated to control or intervention group...
October 2, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29113708/efficacy-and-safety-of-glucagon-like-peptide-1-agonists-on-macrovascular-and-microvascular-events-in-type-2-diabetes-mellitus-a-meta-analysis
#5
P Gargiulo, G Savarese, C D'Amore, F De Martino, L H Lund, F Marsico, S Dellegrottaglie, C Marciano, B Trimarco, P Perrone-Filardi
AIMS: Glucagon-like peptide-1 (GLP-1) agonists improve glycaemic control in type 2 diabetes mellitus (DM). Outcome trials investigating macro and microvascular effects of GLP-1 agonists reported conflicting results. The aim of this study was to assess, in a meta-analysis, the effects of GLP-1 agonists on mortality, major nonfatal cardiovascular (CV) events, renal and retinal events. DATA SYNTHESIS: MEDLINE, Cochrane, ISI Web of Science, SCOPUS and ClinicalTrial...
September 28, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29126670/a-comparison-of-gamma-glutamyl-transferase-and-alkaline-phosphatase-as-prognostic-markers-in-patients-with-coronary-heart-disease
#6
G Ndrepepa, S Holdenrieder, S Cassese, M Fusaro, E Xhepa, K-L Laugwitz, H Schunkert, A Kastrati
BACKGROUND AND AIMS: Whether gamma-glutamyl transferase (GGT) or alkaline phosphatase (ALP) is a better prognostic marker in patients with coronary heart disease (CHD) remains unknown. The aim of this study was to compare the prognostic value of GGT and ALP in patients with CHD. METHODS AND RESULTS: This study included 3768 patients with CHD. The main study outcome was 3-year all-cause mortality. The median values of GGT and ALP were 36.2 U/L and 69.3 U/L. Patients were divided into subgroups according to GGT or ALP activity > or ≤median...
September 23, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29066159/effects-of-fish-oil-derived-fatty-acids-on-suboptimal-cardiovascular-health-a-multicenter-randomized-double-blind-placebo-controlled-trial
#7
Q Zeng, S-Y Dong, Y-P Liu, J Fu, P Shuai, Z-M Zhao, T-X Li
BACKGROUND AND AIMS: Suboptimal health and metabolic disorders are common in the general population. Both are related to cardiovascular disease. Suboptimal cardiovascular health is defined by the presence of both suboptimal health and metabolic disorders. The aim of the study was to investigate the potential benefit of n-3 long-chain polyunsaturated fatty acids (LCPUFA) in participants with suboptimal cardiovascular health. METHODS AND RESULTS: A total of 422 participants with suboptimal cardiovascular health, from two clinics in China, were enrolled from September 2014 to April 2015...
September 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29150407/disease-trends-over-time-and-cd4-ccr5-t-cells-expansion-predict-carotid-atherosclerosis-development-in-patients-with-systemic-lupus-erythematosus
#8
A Baragetti, G A Ramirez, M Magnoni, K Garlaschelli, L Grigore, M Berteotti, I Scotti, E Bozzolo, A Berti, P G Camici, A L Catapano, A A Manfredi, E Ammirati, G D Norata
BACKGROUND AND AIM: Patients with Systemic Lupus Erythematosus (SLE) present increased cardiovascular mortality compared to the general population. Few studies have assessed the long-term development and progression of carotid atherosclerotic plaque in SLE patients. Our aim was to investigate the association of clinical and laboratory markers of disease activity and classical cardiovascular risk factors (CVRF) with carotid atherosclerosis development in SLE patients in a prospective 5-year study...
September 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29074383/association-of-dietary-patterns-with-five-year-degree-and-progression-of-coronary-artery-calcification-in-the-heinz-nixdorf-recall-study
#9
S Frölich, N Lehmann, S Weyers, S Wahl, N Dragano, T Budde, H Kälsch, A A Mahabadi, R Erbel, S Moebus, K H Jöckel, B Schmidt
BACKGROUND AND AIMS: As a modifiable lifestyle factor, diet is hypothesized to play an important role in the progression of atherosclerosis. The aim of this study was to explore associations of comprehensive dietary patterns derived by cluster analysis with degree and progression of coronary artery calcification (CAC) over five years of follow-up. METHODS AND RESULTS: In the population-based Heinz Nixdorf Recall study, 3718 participants (45-75 years; 47.6% men) without coronary heart disease completed a food frequency questionnaire at baseline...
September 18, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29070436/western-diet-increases-cardiac-ceramide-content-in-healthy-and-hypertrophied-hearts
#10
T J Butler, D Ashford, A-M Seymour
BACKGROUND AND AIMS: Obesity and cardiac left ventricular hypertrophy (LVH) are recognised independent risk factors in the development of heart failure (HF). However, the combination of these factors may exacerbate the onset of cardiovascular disease by mechanisms as yet unclear. LVH leads to significant cellular remodelling, including alterations in metabolism which may result in an inappropriate accumulation of lipids and eventual lipotoxicity and apoptosis. The aim of the study was to determine the impact of dietary manipulation on cardiac metabolism in the obese and hypertrophied heart...
September 7, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28986076/association-between-obesity-and-risk-of-chronic-kidney-disease-a-nationwide-cohort-study-in-taiwan
#11
Y-J Lai, H-Y Hu, Y-L Lee, P-W Ku, Y-F Yen, D Chu
BACKGROUND AND AIMS: Increased body fat relates to enhanced inflammatory cytokine production, which, in turn, activates the renin-angiotensin-aldosterone system and increases the risk of chronic kidney disease (CKD). Herein, we aimed to examine the association between obesity and the risk of CKD in a population-representative cohort in Taiwan. METHODS AND RESULTS: A multistage systematic sampling process was applied in the National Health Interview Survey (NHIS) 2000, 2005, and 2009...
August 25, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28967596/fish-intake-is-associated-with-lower-cardiovascular-risk-in-a-mediterranean-population-prospective-results-from-the-moli-sani-study
#12
M Bonaccio, E Ruggiero, A Di Castelnuovo, S Costanzo, M Persichillo, A De Curtis, C Cerletti, M B Donati, G de Gaetano, L Iacoviello
BACKGROUND AND AIMS: Fish consumption reportedly reduces the risk of heart disease, but the evidence of cardiovascular advantages associated with fish intake within Mediterranean cohorts is limited. The aim of this study was to test the association between fish intake and risk of composite coronary heart disease (CHD) and stroke in a large population-based cohort adhering to Mediterranean Diet. METHODS AND RESULTS: Prospective analysis on 20,969 subjects free from cardiovascular disease at baseline, enrolled in the Moli-sani study (2005-2010)...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28965797/single-blind-multicentre-randomized-controlled-trial-testing-the-effects-of-a-novel-nutraceutical-compound-on-plasma-lipid-and-cardiovascular-risk-factors-results-of-the-interim-analysis
#13
RANDOMIZED CONTROLLED TRIAL
V Trimarco, A Battistoni, G Tocci, R Coluccia, M V Manzi, R Izzo, M Volpe
BACKGROUND AND AIMS: The clustering of high levels of LDL cholesterol (LDL-C) and other risk factors represents a predisposing condition for atherosclerotic disease development. Cardiovascular prevention is based on effective control of these conditions. In adult subjects with mild hypercholesterolemia we compared in the real life the effects of a new combination of nutraceuticals on lipid and glucose metabolism and blood pressure with those of an established nutraceutical combination...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28964663/saffron-crocus-sativus-intake-provides-nutritional-preconditioning-against-myocardial-ischemia-reperfusion-injury-in-wild-type-and-apoe-mice-involvement-of-nrf2-activation
#14
P Efentakis, A Rizakou, E Christodoulou, A Chatzianastasiou, M G López, R León, E Balafas, N P E Kadoglou, I Tseti, H Skaltsa, N Kostomitsopoulos, E K Iliodromitis, G Valsami, I Andreadou
BACKGROUND AND AIMS: Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE((-/-)) mice and the underlying molecular mechanisms. METHODS AND RESULTS: WT and ApoE((-/-)) mice were subjected to 30 min I and 2 h R, with the following per os interventions for 4 weeks: 1) WT Control Group, receiving Water for Injection (WFI); 2) WT Crocus Group, receiving SFE at a dose of 60 mg/kg/day; 3) WT Crocus + Wort group, receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus 15 min before R; 4) ApoE((-/-)) Control Group, receiving WFI; 5) ApoE((-/-)) Crocus Group, receiving SFE at a dose of 60 mg/kg/day and 6) ApoE((-/-)) Crocus + Wort: receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus, 15 min before R...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28964662/replacement-therapy-with-levothyroxine-modulates-platelet-activation-in-recent-onset-post-thyroidectomy-subclinical-hypothyroidism
#15
RANDOMIZED CONTROLLED TRIAL
G Desideri, R Bocale, A D'Amore, S Necozione, M Boscherini, G Carnassale, A Barini, A Barini, R Bellantone, C P Lombardi
BACKGROUND AND AIM: Subclinical hypothyroidism has been linked to increased risk of atherosclerotic disease. Soluble CD40 ligand (sCD40L), mainly derived from activated platelets, and the lipid peroxidation product 8-iso-prostaglandin F2α (8-iso-PGF2α) are known to play a relevant pathophysiological role in atherogenesis. In this study, we analyzed the relationship between thyroid hormones and circulating levels of sCD40L and 8-iso-PGF2α in patient with recent-onset post-thyroidectomy subclinical hypothyroidism under replacement therapy...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28958696/substitution-of-water-or-fresh-juice-for-bottled-juice-and-type-2-diabetes-incidence-the-sun-cohort-study
#16
COMPARATIVE STUDY
U Fresan, A Gea, M Bes-Rastrollo, F J Basterra-Gortari, S Carlos, M A Martinez-Gonzalez
BACKGROUND AND AIMS: The relationship between juice consumption and type 2 diabetes (T2D) has not been widely evidenced. Our aims were to prospectively evaluate the associations with T2D incidence of: 1) isovolumetric substitution of a water serving/day for one of fruit juice (different types), and of fresh fruit juice for its bottled version; 2) consumption of total, fresh or bottled juice; 3) energy intake from juices. METHODS AND RESULTS: We followed 17,518 adults without T2D at baseline...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28958692/effects-of-early-overnutrition-on-the-renal-response-to-ang-ii-and-expression-of-raas-components-in-rat-renal-tissue
#17
M Granado, S Amor, N Fernández, G Carreño-Tarragona, M C Iglesias-Cruz, B Martín-Carro, L Monge, A L García-Villalón
BACKGROUND AND AIMS: The aim of this study was to analyze the effects of early overnutrition (EON) on the expression of the renin angiotensin aldosterone system (RAAS) components in renal cortex, renal arteries and renal perivascular adipose tissue (PVAT), as well as the vascular response of renal arteries to Angiotensin II (Ang II). METHODS AND RESULTS: On birth day litters were adjusted to twelve (L12-control) or three (L3-overfed) pups per mother. Half of the animals were sacrificed at weaning (21 days old) and the other half at 5 months of age...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28958691/branched-chain-amino-acid-catabolism-rather-than-amino-acids-plasma-concentrations-is-associated-with-diet-induced-changes-in-insulin-resistance-in-overweight-to-obese-individuals
#18
RANDOMIZED CONTROLLED TRIAL
S Haufe, S Engeli, J Kaminski, H Witt, D Rein, B Kamlage, W Utz, J C Fuhrmann, V Haas, A Mähler, J Schulz-Menger, F C Luft, M Boschmann, J Jordan
BACKGROUND & AIMS: 3-Hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogenesis of insulin resistance. We tested the hypothesis that circulating 3-HIB herald insulin resistance and that metabolic improvement with weight loss are related to changes in BCAAs and 3-HIB. METHODS AND RESULTS: We analyzed plasma and urine in 109 overweight to obese individuals before and after six months on hypocaloric diets reduced in either carbohydrates or fat...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28954706/vitamin-d-deficiency-and-clinical-outcome-in-patients-with-chronic-heart-failure-a-review
#19
REVIEW
C D'Amore, F Marsico, A Parente, S Paolillo, F De Martino, P Gargiulo, F Ferrazzano, A M De Roberto, L La Mura, C Marciano, S Dellegrottaglie, B Trimarco, P Perrone Filardi
AIM: The aim of this review was to summarize evidence on the role of Vitamin D deficiency in heart failure (HF), from pathophysiological mechanisms to clinical effects of Vitamin D supplementation. DATA SYNTHESIS: Chronic HF secondary to left ventricular (LV) systolic dysfunction is a growing health problem, still associated with poor clinical outcome. In recent years, experimental and epidemiological evidence focused on the role of Vitamin D in HF. Cross sectional studies demonstrated that prevalence of HF is increased in patients with Vitamin D deficiency or parathyroid hormone (PTH) plasma level increase, whereas longitudinal studies showed enhanced risk of developing new HF in patients with Vitamin D deficiency...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28851556/visceral-adiposity-index-and-10-year-cardiovascular-disease-incidence-the-attica-study
#20
G-M Kouli, D B Panagiotakos, I Kyrou, E N Georgousopoulou, C Chrysohoou, C Tsigos, D Tousoulis, C Pitsavos
BACKGROUND AND AIMS: Visceral adiposity index (VAI) has been proposed as a marker of visceral adipose tissue accumulation/dysfunction. Our aim was to evaluate potential associations between the VAI and the 10-year cardiovascular disease (CVD) incidence. METHODS AND RESULTS: During 2001-2002, 3042 Greek adults (1514 men; age: ≥18 years) without previous CVD were recruited into the ATTICA study, whilst the 10-year study follow-up was performed in 2011-2012, recording the fatal/non-fatal CVD incidence in 2020 (1010 men) participants...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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