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Nutrition, Metabolism, and Cardiovascular Diseases: NMCD

T Jespersen, N Kruse, T Mehta, M Kuwabara, L Noureddine, D Jalal
AIMS: To examine the association between wine consumption and the prevalence of chronic kidney disease (CKD) and cardiovascular disease (CVD). DATA SYNTHESIS: We performed a cross-sectional logistic regression analysis of National Health and Nutrition Examination Survey (NHANES) in participants 21 years of age or older from 2003 to 2006 in a large representative study of the U.S. POPULATION: Wine consumption was categorized as none (0 glass per day), light (<1 glass per day), or moderate (≥1 glasses per day)...
August 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
F Morreale, C Agnoli, L Roncoroni, S Sieri, V Lombardo, T Mazzeo, L Elli, M T Bardella, C Agostoni, L Doneda, A Scricciolo, F Brighenti, N Pellegrini
BACKGROUND AND AIMS: The only treatment for celiac disease (CD) is strict, lifelong adherence to a gluten-free (GF) diet. To date, there are contrasting data concerning the nutritional adequacy of GF products and diet. There have been no studies that have assessed the adherence of individuals with CD to a Mediterranean diet (MD), a protective dietary regimen against major non-communicable diseases (NCDs). Therefore, we examined the adherence to an MD of a group of Italian individuals with CD and compared it with that of a healthy control group...
July 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
D M Schulte, K Paulsen, K Türk, B Brandt, S Freitag-Wolf, I Hagen, R Zeuner, J O Schröder, W Lieb, A Franke, S Nikolaus, U Mrowietz, S Gerdes, S Schreiber, M Laudes
BACKGROUND AND AIMS: Chronic inflammatory diseases (CID) are associated with a profound increase in cardiovascular (CV) risk resulting in reduced life expectancy. However, LDL-cholesterol is reported to be low in CID patients which is referred to as the "LDL paradoxon". The aim of the present study was to investigate whether LDL-particles in CID exhibit an increased content of the highly atherogenic small-dense LDL subfraction (sdLDL). METHODS AND RESULTS: In this prospective, single center, observational study we enrolled 141 patients with CID (RA n = 59, inflammatory bowel disease (IBD) n = 35, ankylosing spondylitis (SpA) n = 25, Psoriasis n = 22) in 2011 through 2013 to evaluate sdLDL levels before as well as 6 and 26 weeks after initiation of different anti-cytokine therapies (anti-TNFα, anti-IL-6R antibodies)...
July 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M A Larsen, V T Isaksen, O S Moen, L Wilsgaard, M Remijn, E J Paulssen, J Florholmen, R Goll
AIM: To study if the leptin to adiponectin (L:A) ratio, can be a potential biomarker for postprandial triglyceride clearance, insulin resistance (IR) or leptin resistance (LR) in apparently healthy obese, and obese individuals with established metabolic disease. METHODS AND RESULTS: Fifty adult subjects with obesity (BMI ≥30); of which 36 metabolic healthy obese (MHO), and 14 metabolic dysregulated obese (MDO), with clinical and/or biochemical signs of metabolic disease were included...
July 3, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
S De Los Santos, C Palma-Flores, A Zentella-Dehesa, P Canto, R M Coral-Vázquez
BACKGROUND AND AIMS: Several studies propose that (-)-epicatechin, a flavonol present in high concentration in the cocoa, has cardioprotective effects. This study aimed to evaluate the impact of (-)-epicatechin on the development of dilated cardiomyopathy in a δ sarcoglycan null mouse model. METHODS AND RESULTS: δ sarcoglycan null mice were treated for 15 days with (-)-epicatechin. Histological and morphometric analysis of the hearts treated mutant mice showed significant reduction of the vasoconstrictions in the coronary arteries as well as fewer areas with fibrosis and a reduction in the loss of the ventricular wall...
July 3, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
D Luan, D Wang, H Campos, A Baylin
BACKGROUND AND AIMS: Animal models have shown that adipose-derived palmitoleic acid may act as a lipokine by conferring resistance to diet-induced obesity; however, human epidemiologic studies investigating this relationship thus far have not provided data in support of this hypothesis. Because metabolic syndrome and cardiovascular disease are intricately linked with the former being a major risk factor for the latter, we hypothesized that adipose-derived palmitoleic acid may be inversely associated with myocardial infarction...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R Rosário, R Santos, L Lopes, C Agostinis-Sobrinho, C Moreira, J Mota, S Póvoas, A Oliveira, P Padrão, P Moreira, S Abreu
BACKGROUND AND AIMS: The associations between fruit and vegetable consumption and high blood pressure among adults are well studied. Nonetheless, data on the influence of a low consumption of fruit and vegetables on cardiovascular disease risk, particularly blood pressure, among healthy adolescents are scarce. Therefore, we aim to analyse the associations between fruit and/or vegetable intake and blood pressure over a two-year period in healthy adolescents. METHODS AND RESULTS: As part of a cohort, 606 adolescents from the LabMed Physical Activity study were evaluated in 2011 (baseline) and 2013 (follow-up)...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R Y Xu, Y Q Zhou, X M Zhang, Y P Wan, X Gao
BACKGROUND AND AIMS: We prospectively examined the association between three adiposity indices, including body mass index (BMI), waist circumference (WC), and percentage of body fat (PBF), and risk of hypertension in normal-weight Chinese children. METHODS AND RESULTS: The current study included 1526 (713 boys and 813 girls) normal-weight Chinese children (age 6-14 years old), who were free of hypertension at baseline (2014). Heights, body weight, WC, and PBF (estimated by bioelectrical impedance analysis) were measured at the baseline...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
G Mena-Sánchez, N Babio, M Á Martínez-González, D Corella, H Schröder, J Vioque, D Romaguera, J A Martínez, J Lopez-Miranda, R Estruch, J Wärnberg, A Bueno-Cavanillas, L Serra-Majem, J A Tur, F Arós, F J Tinahones, V M Sánchez, J Lapetra, X Pintó, J Vidal, C Vázquez, J M Ordovás, M Delgado-Rodriguez, P Matía-Martín, J Basora, P Buil-Cosiales, R Fernandez-Carrion, M Fitó, J Salas-Salvadó
BACKGROUND AND AIMS: Fermented dairy products have been associated with a better diet quality and cardio-metabolic profile. However, in Mediterranean populations, these associations have not been well characterized. The aim of this study was to assess the diet quality and the associations between the consumption of total fermented dairy products and their subtypes and the prevalence of Metabolic Syndrome (MetS) components in a Mediterranean population at high cardiovascular risk. METHODS AND RESULTS: Baseline cross-sectional analyses were conducted on 6,572 men and women (mean age: 65 years) with overweight or obesity and MetS recruited into the PREDIMED-Plus cohort...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H Halland, M T Lønnebakken, N Pristaj, S Saeed, H Midtbø, E Einarsen, E Gerdts
BACKGROUND AND AIMS: Subclinical cardiac disease, like abnormal left ventricular (LV) geometry or left atrial (LA) dilatation, is common in obesity. Less is known about sex differences in the prevalence and type of subclinical cardiac disease in obesity. METHODS AND RESULTS: Clinical and echocardiographic data from 581 women and men without established cardiovascular disease and body mass index (BMI) > 27.0 kg/m2 participating in the FAT associated CardiOvasculaR dysfunction (FATCOR) study was analyzed...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
E S Eshak, A E Arafa
BACKGROUND AND AIM: Thiamine, also known as vitamin B1, functions as a cofactor in the metabolism of carbohydrates and amino acids. Thiamine deficiency has been suggested to be associated with many cardiovascular diseases (CVDs) and risk factors including type 1 and type 2 diabetes (T1D and T2D, respectively), obesity, chronic vascular inflammation, dyslipidemia, heart failure (HF), myocardial infarction (MI) and conduction defects, and depression. The aim of this review was to explore the evidence of thiamine deficiency among subjects with CVDs or risk factors, illustrate the theories explaining the thiamine-CVDs associations, and describe the effect of thiamine supplementation...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Jia, S Xu, Y Xing, W Zhang, X Yu, Y Zhao, J Ming, Q Ji
BACKGROUND AND AIMS: Several studies have reported increased cardiovascular risks in normal weight obesity (NWO) populations. We aimed to investigate the prevalence of NWO and its relationships with cardiometabolic risks in Chinese patients. METHODS AND RESULTS: The data were from the 2007-2008 China National Diabetes and Metabolic Disorders Study. The body fat (BF) was measured using the biological impedance method. NWO was defined as a normal BMI (18.5-23.9 kg/m2 ) but with excess BF% (BF% ≥ 24% for men and ≥33% for women)...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Z Wang, A M Siega-Riz, P Gordon-Larsen, J Cai, L S Adair, B Zhang, B M Popkin
AIM: We examined the association between diet quality and diabetes and major cardiometabolic risks among adults in China. METHODS AND RESULTS: We developed the China Dietary Guideline Index (CDGI) based on the 2007 Chinese dietary guidelines and tailored the Alternate Healthy Eating Index 2010 (which we call the tAHEI) to assess diet quality. Our analysis linked the dietary intake and covariates measured in 2006 with CM risk factors measured in 2009. We used diet data the longitudinal China Health and Nutrition Survey 2006 collected in 3 consecutive 24-h recalls from 4440 adults aged 18 to 65 to calculate both the tAHEI and the CDGI scores...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Fingeret, P Marques-Vidal, P Vollenweider
BACKGROUND AND AIMS: Metabolically healthy obese (MHO) individuals are devoid of many metabolic abnormalities, but how this condition is maintained over time remains debated. We assessed the prevalence of MHO over time and the incidence of hypertension (HTN), dyslipidemia, and type 2 diabetes mellitus (T2DM) in MHO as compared with metabolically healthy non obese (MHNO). METHODS AND RESULTS: Prospective, population-based study including 3038 participants (49.9 ± 9...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
C Mele, M A Tagliaferri, G Saraceno, S Mai, R Vietti, M Zavattaro, G Aimaretti, M Scacchi, P Marzullo
BACKGROUND AND AIMS: Uric acid (UA) is a byproduct of the high-energy purine metabolism and is conventionally regarded as a marker of cardio-metabolic impairment. Its potential relationship with energy homeostasis is unknown to date. METHODS AND RESULTS: In a cross-sectional study on 121 otherwise healthy obese and 99 sex- and-age-matched lean subjects, UA levels were analyzed in relation to metabolic health, inflammatory markers, respiratory quotient (RQ) and resting energy expenditure (REE) as assessed by indirect calorimetry, fat mass (%FM) and fat-free mass (FFM) as determined by bioimpedance analysis...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
M Cabral, J Araújo, C Lopes, E Ramos
BACKGROUND AND AIMS: Diet comprises factors with anti and pro-inflammatory potential that can contribute to modulate obesity-induced inflammation. We aimed to assess the association between food intake and high-sensitivity C-reactive protein (hsCRP) levels in adolescents. METHODS AND RESULTS: A cross-sectional analysis of 991 adolescents aged 13 years old was conducted as part of the EPITeen cohort, Porto, Portugal. Food intake was assessed by a food frequency questionnaire and thirteen food groups were defined...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
H-W Zhang, X Zhao, Y-L Guo, Y Gao, C-G Zhu, N-Q Wu, J-J Li
BACKGROUND AND AIMS: The role of lipoprotein (a) [Lp(a)] in coronary artery diseases (CAD) with special clinical background such as type 2 diabetes mellitus (T2DM) has not been fully determined. The aim of the present study was to investigate the relation of Lp(a) to type 2 diabetic patients with or without CAD. METHODS AND RESULTS: A total of 2040 consecutive patients with T2DM who received selective coronary angiography (CAG) due to angina-like chest pain were enrolled...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
A Deng, S Pattanaik, A Bhattacharya, J Yin, L Ross, C Liu, J Zhang
BACKGROUND: There is a paucity of studies examining the beneficial effects of fish consumption on cardiovascular diseases (CVDs) among adults with diabetes, who experience a substantially high risk of CVDs. METHODS AND RESULTS: We analyzed the data of 1136 adults with diabetes mellitus aged 18 years and older who participated in the National Health and Nutrition Examination Survey, 1988-1994, and were followed up through December 31, 2010. We used Cox regression to estimate the adjusted hazard ratios (HRs) for the relative risk across the levels of fish consumption...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Y-J Kwon, H-S Lee, J-W Lee
BACKGROUND AND AIMS: Bilirubin has antioxidant and anti-inflammatory properties; serum bilirubin levels have been known to be inversely associated with cardiovascular disease. However, the effects of different bilirubin subtypes on cardiometabolic traits are unknown. In this study, we aimed to determine whether direct bilirubin is more strongly correlated with small, dense low-density lipoprotein (sdLDL) compared to other bilirubin subtypes. We also investigated which LDL subfractions exhibited the highest correlation with direct bilirubin...
October 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
R C Castiglione, C M L Barbosa, L F M Prota, S R Marques-Neto, M Perri-Oliveira, E Helal-Neto, V Morandi, C Barja-Fidalgo, E Bouskela
BACKGROUND AND AIMS: Obesity promotes a persistent inflammatory process in the adipose tissue, activating the endothelium and leading to vascular dysfunction. Preadipocytes can interact with endothelial cells in a paracrine way stimulating angiogenesis. However, the potential of preadipocytes from adipose tissue of high fat diet (HFD) fed animal to stimulate angiogenesis has not been evaluated yet. The aim of this study was to investigate the effects of such diet on the angiogenic potential of preadipocytes in a mice model...
September 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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