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International Journal of Methods in Psychiatric Research

Renee Grenon, Alena McKenna, Hilary Maxwell, Samantha Carlucci, Agostino Brugnera, Dominique Schwartze, Nicole Hammond, Iryna Ivanova, Nancy Mcquaid, Genevieve Proulx, Giorgio A Tasca
OBJECTIVE: We investigated the quality of randomized controlled trials (RCTs) that included direct comparisons of psychotherapy for adults with an eating disorder (ED). METHOD: Thirty-five direct comparison RCTs of psychotherapy for adults diagnosed with an ED were rated using the Randomized Controlled Trials Psychotherapy Quality Rating Scale (RCT-PQRS). RESULTS: The mean total RCT-PQRS score (mean = 28.26; SD = 7.04) was in line with those that were reported for RCTs of psychotherapy for depression and anxiety disorders...
July 20, 2018: International Journal of Methods in Psychiatric Research
Steven D Targum, J Cara Pendergrass, Sang Lee, Antony Loebel
OBJECTIVES: Site-independent ratings surveillance assessed ratings reliability in a clinical trial. METHODS: Inter-rater reliability was assessed at the screen visit in a 6-week, double-blind, placebo-controlled study of lurasidone for the treatment of major depressive disorder (MDD) with subthreshold hypomanic ("mixed") symptoms ( NCT01421134). Site-based Montgomery-Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) interviews were paired with 184 site-independent ratings derived from audio-digital recordings...
June 26, 2018: International Journal of Methods in Psychiatric Research
Petr Winkler, Tomáš Formánek, Karolína Mladá, Pavla Cermakova
OBJECTIVES: The CZEch Mental health Study (CZEMS) was launched to inform the ongoing mental health care reform. This paper describes rationale, methods, and the plan for the future analyses of this project. METHODS: A cross-sectional survey on a representative sample of the general adult noninstitutionalized population of the Czech Republic was conducted. Two-stage sampling was utilized and respondents were interviewed by centrally trained staff using a paper and pencil interviewing...
June 21, 2018: International Journal of Methods in Psychiatric Research
Tammas Kelly
OBJECTIVES: Many studies indicate that bipolar disorders are underdiagnosed. Yet from 2007 to 2008, a series of publications asserted that bipolar disorders were being overdiagnosed. This review examines the methods used in the studies that reported bipolar disorders were being overdiagnosed. METHODS: A literature search for studies with original data related to overdiagnosis of bipolar disorders was performed. RESULTS: Four studies were found indicating bipolar disorders were being overdiagnosed...
June 14, 2018: International Journal of Methods in Psychiatric Research
Fei Ye, Qiongqiong Zhan, Wenhuan Xiao, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: Many research indicate that the tardive dyskinesia (TD) is generally linked with long-term antipsychotic therapy for schizophrenia. Glial cell line-derived neurotrophic factor (GDNF) is a critical role in the protection of catecholaminergic, dopaminergic, and cholinergic neurons. Thus, we examined the serum GDNF levels in schizophrenia patients with TD (WTD) and without TD (NTD) and compared with healthy controls (HC), respectively. METHODS: Totally 75 males with schizophrenia were recruited into this study...
June 14, 2018: International Journal of Methods in Psychiatric Research
Ahmad Hajebi, Abbas Motevalian, Masoumeh Amin-Esmaeili, Afarin Rahimi-Movaghar, Vandad Sharifi, Leila Hoseini, Behrang Shadloo, Ramin Mojtabai
OBJECTIVES: The aims of the study were to translate into Persian and culturally adapt the Kessler Psychological Distress Scales, K10 and K6, and to assess their reliability and validity. METHOD: The sample was recruited from primary health care (PHC) settings by quota nonprobability sampling, stratified by sex and age. Validity was assessed against the Composite International Diagnostic Interview (v2.1). The psychometric properties of K6 and K10 were also compared with the 12-item General Health Questionnaire (GHQ-12)...
June 11, 2018: International Journal of Methods in Psychiatric Research
Lauren Greenberg, Stephen Bremner, Catherine Carr, Stefan Priebe
OBJECTIVES: Little attention has been given to the common assessment problem that clinicians assess outcomes of several patients and may rate them in comparison to one another, whereas patients assess only their own outcomes without any comparison. We explored empirically whether this would lead to a greater variability of clinician ratings as compared to patient ratings. METHODS: Data from two independent samples in which clinicians and patients, using consistent instruments, rated their therapeutic relationships...
June 6, 2018: International Journal of Methods in Psychiatric Research
Federica Edith Pisa, Francesca Palese, Federico Romanese, Fabio Barbone, Giancarlo Logroscino, Oliver Riedel
OBJECTIVES: Reliable information on preadmission medications is essential for inpatients with dementia, but its quality has hardly been evaluated. We assessed the completeness of information and factors associated with incomplete recording. METHODS: We compared preadmission medications recorded in hospital electronic medical records (EMRs) with community-pharmacy dispensations in hospitalizations with discharge code for dementia at the University Hospital of Udine, Italy, 2012-2014...
June 5, 2018: International Journal of Methods in Psychiatric Research
Dagmar Van Liefferinge, Edmund Sonuga-Barke, Marina Danckaerts, Kirill Fayn, Nady Van Broeck, Saskia van der Oord
OBJECTIVES: Emotional lability (EL) is an important trans-diagnostic concept that is associated with significant functional impairment in childhood and adolescence. EL is typically measured with questionnaires, although little is known about the ecological validity of these ratings. In this paper, we undertook 2 studies addressing this issue by examining the relationship between rating-based measures of EL and directly measured emotional expressions and experiences. Furthermore, the associations between directly measured emotional expressions and experiences and attention-deficit/hyperactivity disorder (ADHD) symptomatology were also examined, given the clear association of EL with ADHD in former research...
May 30, 2018: International Journal of Methods in Psychiatric Research
Aja Louise Murray, Tom Booth, Denis Ribeaud, Manuel Eisner
OBJECTIVES: It is well-known that in cross-sectional analyses, agreement between informants is modest as best when rating attention-deficit/hyperactivity disorder and other disruptive behaviour disorder symptoms. We here aimed to develop recommendations for the use of multi-informant data in the context of longitudinal developmental analyses that examine symptom trajectories over time. METHOD: Using parallel process modelling, we estimated parent-teacher agreement in inattention and hyperactivity/impulsivity symptom initial levels and slopes across the elementary school years (ages 7, 9, and 11) for a community sample of n = 1,388 youth...
May 30, 2018: International Journal of Methods in Psychiatric Research
David C Buitenweg, Ilja L Bongers, Dike van de Mheen, Hans A M van Oers, Chijs Van Nieuwenhuizen
OBJECTIVES: Conventional approaches to quality of life (QoL) measurement rely heavily on verbal, language-based communication. They require respondents to have significant cognitive and verbal ability, making them potentially unsuitable for people with severe mental health problems. To facilitate an alternative approach to QoL assessment, the current study aims to develop an alternative, visual representation of QoL for people with severe mental health problems. METHODS: An alternative, visual adaptation of the concept mapping method was used to construct this visual representation of QoL...
May 25, 2018: International Journal of Methods in Psychiatric Research
Cecilia W P Li-Tsang, Tim M H Li, Mandy S W Lau, Choco H Y Ho, Howard W H Leung
OBJECTIVES: Attention deficit hyperactivity disorder (ADHD) and learning difficulties (LDs) are proposed as 2 overlapping disorders. The objective of this study was to investigate the handwriting performance in ADHD and comorbid ADHD-LD adolescents. METHODS: The study examined the Chinese and English handwriting performance and sensorimotor skills of 32 ADHD, 12 ADHD-LD, and their matched controls. RESULTS: Participants with ADHD had comparable writing time and speed, but the readability was lower than their controls...
May 15, 2018: International Journal of Methods in Psychiatric Research
Hui G Cheng, James C Anthony
OBJECTIVE: In this study of newly incident drinkers (NIDs), we (a) investigate and calibrate measurement equivalence of 7 clinical features of an alcohol dependence syndrome (ADS) across sex and age-of-onset subgroups and (b) estimate female-male differences in ADS levels soon after taking the first full drink, with focus on those with first full drink before the 24th birthday. METHODS: The study population is 12- to 23-year-old NIDs living in the United States (n = 33,561)...
May 9, 2018: International Journal of Methods in Psychiatric Research
Lucas B Rizzo, Walter Swardfager, Pawan Kumar Maurya, Maiara Zeni Graiff, Mariana Pedrini, Elson Asevedo, Ana Cláudia Cassinelli, Moisés E Bauer, Quirino Cordeiro, Jan Scott, Elisa Brietzke, Hugo Cogo-Moreira
OBJECTIVES: The study aims to generate an immunological age (IA) trait on the basis of immune cell differentiation parameters, and to test whether the IA is related to age and disease characteristics. METHODS: Forty-four euthymic type I bipolar disorder patients were included in this study. Five immunosenescence-related parameters were assessed: proportions of late-differentiated cells (e.g., CD3+CD8+CD28-CD27- and CD3-CD19+IgD-CD27-), and the expression of CD69, CD71, and CD152 after stimulation...
April 25, 2018: International Journal of Methods in Psychiatric Research
Janna Marie Bas-Hoogendam, Anita Harrewijn, Renaud L M Tissier, Melle J W van der Molen, Henk van Steenbergen, Irene M van Vliet, Catrien G Reichart, Jeanine J Houwing-Duistermaat, P Eline Slagboom, Nic J A van der Wee, P Michiel Westenberg
OBJECTIVES: Social anxiety disorder (SAD) is a serious and prevalent psychiatric condition, with a heritable component. However, little is known about the characteristics that are associated with the genetic component of SAD, the so-called "endophenotypes". These endophenotypes could advance our insight in the genetic susceptibility to SAD, as they are on the pathway from genotype to phenotype. The Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) is the first multiplex, multigenerational study aimed to identify neurocognitive endophenotypes of social anxiety...
June 2018: International Journal of Methods in Psychiatric Research
Marlene Penz, Magdalena K Wekenborg, Lars Pieper, Katja Beesdo-Baum, Andreas Walther, Robert Miller, Tobias Stalder, Clemens Kirschbaum
OBJECTIVES: The Dresden Burnout Study (DBS) is a 12-year longitudinal cohort study that aims to provide a description of the burnout syndrome on the basis of time and symptom criteria with a special focus on the search for biomarkers. Biological and psychosocial approaches are applied to examine the long-term course and consequences of burnout within a population-based German-speaking sample aged 18 to 68 years. METHODS: Demographics and psychosocial data are generated by online assessments, including demographics and questionnaires on burnout, burnout-related constructs, work-environment, and health-related factors...
June 2018: International Journal of Methods in Psychiatric Research
Danielle J Maack, Chad Ebesutani
OBJECTIVES: Carver and White's behavioral inhibition system and behavioral activation system (BIS/BAS) scales are the most widely used to assess constructs of the revised reinforcement sensitivity theory. This study provides a re-examination of the latent structure of the original BIS/BAS scales. METHODS: The interpretability of the three purported BAS subfactors relative to a "general behavioral activation" factor was assessed using Schmid-Leiman and standard confirmatory factor analysis...
June 2018: International Journal of Methods in Psychiatric Research
Andries T Marees, Hilde de Kluiver, Sven Stringer, Florence Vorspan, Emmanuel Curis, Cynthia Marie-Claire, Eske M Derks
OBJECTIVES: Genome-wide association studies (GWAS) have become increasingly popular to identify associations between single nucleotide polymorphisms (SNPs) and phenotypic traits. The GWAS method is commonly applied within the social sciences. However, statistical analyses will need to be carefully conducted and the use of dedicated genetics software will be required. This tutorial aims to provide a guideline for conducting genetic analyses. METHODS: We discuss and explain key concepts and illustrate how to conduct GWAS using example scripts provided through GitHub (https://github...
June 2018: International Journal of Methods in Psychiatric Research
Christoph J Wagner, Charalabos Markos Dintsios, Florian G Metzger, Helmut L'Hoest, Ursula Marschall, Bjoern Stollenwerk, Stephanie Stock
OBJECTIVES: To measure persistence and nonrecurrence of depression treatment and investigate potential risk factors. METHODS: We retrospectively observed a closed cohort of insurees with new-onset depression treatment in 2007 and without most psychiatric comorbidity for 16 quarters (plus one to ascertain discontinuation). We linked inpatient/outpatient/drug-data per person and quarter. Person-quarters containing specified depression services were classified as depression-treatment-person-quarters (DTPQ)...
June 2018: International Journal of Methods in Psychiatric Research
Christina C Norman, Kate McDonald, Amanda E Schneider, Igor Malinovsky, Emily Goldmann, Michael K Blauschild, Cynthia Driver
OBJECTIVES: This paper describes the objectives, design, and methods of the Mental Health Needs Assessment Study (MHNAS). The objective of the MHNAS was to assess the needs of individuals transitioning to the community following psychiatric hospitalization and again 3-5 months later to inform community service planning. Needs were defined broadly to include domains like housing, employment, treatment, and social support. METHODS: The MHNAS used a 2-stage clustered sampling approach where the primary sampling units were hospitals and secondary sampling units were patients...
June 2018: International Journal of Methods in Psychiatric Research
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