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European Respiratory Review: An Official Journal of the European Respiratory Society

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https://www.readbyqxmd.com/read/30578338/beyond-idiopathic-pulmonary-fibrosis-the-world-of-progressive-fibrosing-interstitial-lung-disease
#1
EDITORIAL
Sergio Harari
No abstract text is available yet for this article.
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578337/healthcare-utilisation-and-costs-in-the-diagnosis-and-treatment-of-progressive-fibrosing-interstitial-lung-diseases
#2
REVIEW
Colin Holtze, Kevin Flaherty, Michael Kreuter, Fabrizio Luppi, Teng Moua, Carlo Vancheri, Mary B Scholand
There are over 200 interstitial lung diseases (ILDs). In addition to patients with idiopathic pulmonary fibrosis (IPF), a percentage of patients with other ILDs also develop progressive fibrosis of the lung during their disease course. Patients with progressive-fibrosing ILDs may show limited response to immunomodulatory therapy, worsening symptoms and lung function and, ultimately, early mortality. There are few data for ILDs that may present a progressive fibrosing phenotype specifically, but we believe the burden and healthcare costs associated with these conditions may be comparable to those reported in IPF...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578336/the-epidemiology-of-idiopathic-pulmonary-fibrosis-and-interstitial-lung-diseases-at-risk-of-a-progressive-fibrosing-phenotype
#3
REVIEW
Amy L Olson, Alex H Gifford, Naohiko Inase, Evans R Fernández Pérez, Takafumi Suda
The availability of epidemiological data relating to interstitial lung diseases (ILDs) has increased over recent years, but information on the prevalence and incidence of ILDs of different aetiologies remains limited. Despite global distribution, the proportion of patients who develop a progressive phenotype across different ILDs is not well known. Disease behaviour is well documented in idiopathic pulmonary fibrosis but idiosyncratic in other ILDs that may present a progressive fibrosing phenotype. Possible reasons may include the heterogeneous nature of the aetiology, the complexity of diagnosis (and subsequent documentation of cases) and the methods employed to retrospectively analyse patient databases...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578335/presentation-diagnosis-and-clinical-course-of-the-spectrum-of-progressive-fibrosing-interstitial-lung-diseases
#4
REVIEW
Vincent Cottin, Nikhil A Hirani, David L Hotchkin, Anoop M Nambiar, Takashi Ogura, María Otaola, Dirk Skowasch, Jong Sun Park, Hataya K Poonyagariyagorn, Wim Wuyts, Athol U Wells
Although these conditions are rare, a proportion of patients with interstitial lung diseases (ILDs) may develop a progressive-fibrosing phenotype. Progressive fibrosis is associated with worsening respiratory symptoms, lung function decline, limited response to immunomodulatory therapies, decreased quality of life and, potentially, early death. Idiopathic pulmonary fibrosis may be regarded as a model for other progressive-fibrosing ILDs. Here we focus on other ILDs that may present a progressive-fibrosing phenotype, namely idiopathic nonspecific interstitial pneumonia, unclassifiable idiopathic interstitial pneumonia, connective tissue disease-associated ILDs ( e...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578334/patients-perceptions-and-patient-reported-outcomes-in-progressive-fibrosing-interstitial-lung-diseases
#5
REVIEW
Jeffrey J Swigris, Kevin K Brown, Rayid Abdulqawi, Ketan Buch, Daniel F Dilling, Dirk Koschel, Krishna Thavarajah, Rade Tomic, Yoshikazu Inoue
The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578333/pharmacological-management-of-progressive-fibrosing-interstitial-lung-diseases-a-review-of-the-current-evidence
#6
REVIEW
Luca Richeldi, Francesco Varone, Miguel Bergna, Joao de Andrade, Jeremy Falk, Robert Hallowell, Stéphane Jouneau, Yasuhiro Kondoh, Lee Morrow, Winfried Randerath, Mary Strek, Gabriela Tabaj
A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578332/role-of-imaging-in-progressive-fibrosing-interstitial-lung-diseases
#7
REVIEW
Simon L F Walsh, Anand Devaraj, Juan Ignacio Enghelmayer, Kazuma Kishi, Rafael S Silva, Nina Patel, Milton D Rossman, Claudia Valenzuela, Carlo Vancheri
Imaging techniques are an essential component of the diagnostic process for interstitial lung diseases (ILDs). Chest radiography is frequently the initial indicator of an ILD, and comparison of radiographs taken at different time points can show the rate of disease progression. However, radiography provides only limited specificity and sensitivity and is primarily used to rule out other diseases, such as left heart failure. High-resolution computed tomography (HRCT) is a more sensitive method and is considered central in the diagnosis of ILDs...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30578331/acute-exacerbations-of-progressive-fibrosing-interstitial-lung-diseases
#8
REVIEW
Martin Kolb, Benjamin Bondue, Alberto Pesci, Yasunari Miyazaki, Jin Woo Song, Nitin Y Bhatt, John T Huggins, Justin M Oldham, Maria L Padilla, Jesse Roman, Shane Shapera
Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and high mortality. Numerous studies have documented acute exacerbation in idiopathic pulmonary fibrosis (IPF), but less is known about these events in other ILDs that may present a progressive-fibrosing phenotype. We propose defining acute exacerbation as an acute, clinically significant respiratory deterioration, typically less than 1 month in duration, together with computerised tomography imaging showing new bilateral glass opacity and/or consolidation superimposed on a background pattern consistent with fibrosing ILDs...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30567935/the-changing-face-of-the-european-respiratory-review
#9
EDITORIAL
Sergio Harari
No abstract text is available yet for this article.
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30567934/cyst-related-primary-lung-malignancies-an-important-and-relatively-unknown-imaging-appearance-of-early-lung-cancer
#10
REVIEW
Onno M Mets, Cornelia M Schaefer-Prokop, Pim A de Jong
It is well known that lung cancer can manifest itself in imaging as solid and subsolid nodules or masses. However, in this era of increased computed tomography use another morphological computed tomography appearance of lung cancer is increasingly being recognised, presenting as a malignancy in relation to cystic airspaces. Despite the fact that it seems to be a relatively common finding in daily practice, literature on this entity is scarce and presumably the overall awareness is limited. This can lead to misinterpretation and delay in diagnosis and, therefore, increased awareness is urgently needed...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30567933/palliative-care-in-pulmonary-arterial-hypertension-an-underutilised-treatment
#11
REVIEW
Ghaleb Khirfan, Adriano R Tonelli, Jennifer Ramsey, Sandeep Sahay
Pulmonary arterial hypertension (PAH) is a condition characterised by increased pulmonary vascular resistance which can lead to right heart failure and premature death. It imposes a significant burden on patients' lives, affecting their physical, emotional and social wellbeing. Pharmacological therapies are the mainstay of treatment; while they are not curative, they can alleviate patient suffering, improve quality of life and delay disease progression. Despite these therapies, disease progresses in a significant number of patients, who are faced with the debilitating symptoms of PAH and treatment adverse effects...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30567932/the-use-of-chest-magnetic-resonance-imaging-in-interstitial-lung-disease-a-systematic-review
#12
REVIEW
Chiara Romei, Laura Turturici, Laura Tavanti, Jelle Miedema, Sara Fiorini, Massimo Marletta, Piotr Wielopolski, Harm Tiddens, Fabio Falaschi, Pierluigi Ciet
Thin-slices multi-detector computed tomography (MDCT) plays a key role in the differential diagnosis of interstitial lung disease (ILD). However, thin-slices MDCT has a limited ability to detect active inflammation, which is an important target of newly developed ILD drug therapy. Magnetic resonance imaging (MRI), thanks to its multi-parameter capability, provides better tissue characterisation than thin-slices MDCT.Our aim was to summarise the current status of MRI applications in ILD and to propose an ILD-MRI protocol...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30487292/fatal-recurrent-vte-after-anticoagulant-treatment-for-unprovoked-vte-a-systematic-review
#13
REVIEW
Sake J van der Wall, Liselotte M van der Pol, Yvonne M Ende-Verhaar, Suzanne C Cannegieter, Sam Schulman, Paolo Prandoni, Marc Rodger, Menno V Huisman, Frederikus A Klok
Current guidelines recommend long-term anticoagulant therapy in patients with unprovoked venous thromboembolism (VTE). The risk of fatal recurrent VTE after treatment discontinuation ( versus that of fatal bleeding during anticoagulation) is of particular relevance in the decision to continue or stop anticoagulation after the first 3 months. Our primary aim was to provide a point-estimate of the yearly rate of fatal recurrent VTE and VTE case-fatality rate in patients with unprovoked VTE after anticoagulation cessation...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30487291/sustained-inflations-and-avoiding-mechanical-ventilation-to-prevent-death-or-bronchopulmonary-dysplasia-a-meta-analysis
#14
REVIEW
Hendrik S Fischer, Georg M Schmölzer, Po-Yin Cheung, Christoph Bührer
Sustained inflations and avoidance of endotracheal mechanical ventilation (eMV) are delivery room interventions aimed at preventing bronchopulmonary dysplasia (BPD). Their effectiveness is the subject of the present meta-analysis.The databases MEDLINE, EMBASE and CENTRAL were searched for randomised controlled trials (RCTs) of preterm infants that compared: 1) sustained inflations with intermittent positive-pressure ventilation; and 2) a non-intubated strategy of respiratory support with one that prescribed eMV at an earlier stage...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30463874/-cardiovascular-disease-and-copd-dangerous-liaisons-klaus-f-rabe-john-r-hurst-and-samy-suissa-eur-respir-rev-2018-27-180057
#15
(no author information available yet)
No abstract text is available yet for this article.
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30463873/risk-factors-for-mortality-and-mortality-rates-in-interstitial-lung-disease-patients-in-the-intensive-care-unit
#16
REVIEW
Julio A Huapaya, Erin M Wilfong, Christopher T Harden, Roy G Brower, Sonye K Danoff
Data on interstitial lung disease (ILD) outcomes in the intensive care unit (ICU) is of limited value due to population heterogeneity. The aim of this study was to examine risk factors for mortality and ILD mortality rates in the ICU.We performed a systematic review using five databases. 50 studies were identified and 34 were included: 17 studies on various aetiologies of ILD (mixed-ILD) and 17 on idiopathic pulmonary fibrosis (IPF). In mixed-ILD, elevated APACHE score, hypoxaemia and mechanical ventilation are risk factors for mortality...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30463872/current-opinions-for-the-management-of-asthma-associated-with-ear-nose-and-throat-comorbidities
#17
REVIEW
Angelica Tiotiu, Davor Plavec, Silviya Novakova, Stefan Mihaicuta, Plamena Novakova, Marina Labor, Andras Bikov
Ear, nose and throat (ENT) comorbidities are common in patients with asthma and are frequently associated with poorer asthma outcomes. All these comorbidities are "treatable traits" in asthma. Identification and management of these disorders may spare medication usage and contribute to improved asthma control and quality of life, and a decrease in exacerbation rates.This review summarises recent data about the prevalence, clinical impact and treatment effects of ENT comorbidities in asthma including allergic rhinitis, chronic rhinosinusitis with and without nasal polyposis, aspirin-exacerbated respiratory disease, obstructive sleep apnoea and vocal cord dysfunction...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30282634/cardiovascular-disease-and-copd-dangerous-liaisons
#18
REVIEW
Klaus F Rabe, John R Hurst, Samy Suissa
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently occur together and their coexistence is associated with worse outcomes than either condition alone. Pathophysiological links between COPD and CVD include lung hyperinflation, systemic inflammation and COPD exacerbations. COPD treatments may produce beneficial cardiovascular (CV) effects, such as long-acting bronchodilators, which are associated with improvements in arterial stiffness, pulmonary vasoconstriction, and cardiac function...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30257909/randomised-controlled-trials-and-real-life-studies-two-answers-for-one-question
#19
EDITORIAL
Sergio Harari
No abstract text is available yet for this article.
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30257908/cadmium-lung-adsorption-citrullination-and-an-enhanced-risk-of-copd
#20
LETTER
David Hutchinson
No abstract text is available yet for this article.
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
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