journal
MENU ▼
Read by QxMD icon Read
search

European Respiratory Review: An Official Journal of the European Respiratory Society

journal
https://www.readbyqxmd.com/read/30282634/cardiovascular-disease-and-copd-dangerous-liaisons
#1
REVIEW
Klaus F Rabe, John R Hurst, Samy Suissa
Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) frequently occur together and their coexistence is associated with worse outcomes than either condition alone. Pathophysiological links between COPD and CVD include lung hyperinflation, systemic inflammation and COPD exacerbations. COPD treatments may produce beneficial cardiovascular (CV) effects, such as long-acting bronchodilators, which are associated with improvements in arterial stiffness, pulmonary vasoconstriction, and cardiac function...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30257909/randomised-controlled-trials-and-real-life-studies-two-answers-for-one-question
#2
EDITORIAL
Sergio Harari
No abstract text is available yet for this article.
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30257908/cadmium-lung-adsorption-citrullination-and-an-enhanced-risk-of-copd
#3
LETTER
David Hutchinson
No abstract text is available yet for this article.
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30158278/pulmonary-hypertension-associated-with-neurofibromatosis-type-1
#4
Etienne-Marie Jutant, Barbara Girerd, Xavier Jaïs, Laurent Savale, Caroline O'Connell, Frederic Perros, Olivier Sitbon, Marc Humbert, David Montani
Neurofibromatosis type 1 (NF1), also known as von Recklinghausen disease, is a frequent autosomal dominant genetic disorder with a prevalence of 1 in 3000. Pulmonary hypertension (PH) associated with NF1 (PH-NF1) is a rare but severe complication of NF1 and is classified as Group 5 PH, defined as "PH with unclear and/or multifactorial mechanisms". A literature review in PubMed on the association between NF1 and PH identified 18 articles describing 31 cases. PH-NF1 was characterised by a female predominance, an advanced age at diagnosis, an association with parenchymal lung disease in two out of three cases and poor long-term prognosis...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30158277/how-long-is-too-long-a-scoping-review-of-health-system-delays-in-lung-cancer
#5
REVIEW
Ashanya Malalasekera, Sharon Nahm, Prunella L Blinman, Steven C Kao, Haryana M Dhillon, Janette L Vardy
Earlier access to lung cancer specialist (LCS) care improves survival, highlighting the need for streamlined patient referral. International guidelines recommend 14-day maximum time intervals from general practitioner (GP) referral to first LCS appointment ("GP-LCS interval"), and diagnosis to treatment ("treatment interval"). We compared time intervals in lung cancer care against timeframe benchmarks, and explored barriers and facilitators to timely care.We conducted a scoping review of literature from MEDLINE, Embase, Scopus and hand searches...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30158276/the-broad-spectrum-of-lung-diseases-in-primary-antibody-deficiencies
#6
REVIEW
Francesco Cinetto, Riccardo Scarpa, Marcello Rattazzi, Carlo Agostini
Human primary immunodeficiency diseases (PIDs) represent a heterogeneous group of more than 350 disorders. They are rare diseases, but their global incidence is more relevant than generally thought. The underlying defect may involve different branches of the innate and/or adaptive immune response. Thus, the clinical picture may range from severe phenotypes characterised by a broad spectrum of infections to milder infectious phenotypes due to more selective (and frequent) immune defects. Moreover, infections may not be the main clinical features in some PIDs that might present with autoimmunity, auto-inflammation and/or cancer...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/30068688/precision-medicine-in-copd-where-are-we-and-where-do-we-need-to-go
#7
Venkataramana K Sidhaye, Kristine Nishida, Fernando J Martinez
Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29997247/noninvasive-ventilation-in-acute-respiratory-failure-which-recipe-for-success
#8
Raffaele Scala, Lara Pisani
Noninvasive positive-pressure ventilation (NPPV) to treat acute respiratory failure has expanded tremendously over the world in terms of the spectrum of diseases that can be successfully managed, the locations of its application and achievable goals.The turning point for the successful expansion of NPPV is its ability to achieve the same physiological effects as invasive mechanical ventilation with the avoidance of the life-threatening risks correlated with the use of an artificial airway.Cardiorespiratory arrest, extreme psychomotor agitation, severe haemodynamic instability, nonhypercapnic coma and multiple organ failure are absolute contraindications for NPPV...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29997246/bronchiectasis-a-case-based-approach-to-investigation-and-management
#9
REVIEW
Martina Contarini, Simon Finch, James D Chalmers
Bronchiectasis is a chronic respiratory disease characterised by a syndrome of productive cough and recurrent respiratory infections due to permanent dilatation of the bronchi. Bronchiectasis represents the final common pathway of different disorders, some of which may require specific treatment. Therefore, promptly identifying the aetiology of bronchiectasis is recommended by the European Respiratory Society guidelines. The clinical history and high-resolution computed tomography (HRCT) features can be useful to detect the underlying causes...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29997245/systematic-review-of-drug-effects-in-humans-and-models-with-surfactant-processing-disease
#10
REVIEW
Dymph Klay, Thijs W Hoffman, Ankie M Harmsze, Jan C Grutters, Coline H M van Moorsel
Fibrotic interstitial pneumonias are a group of rare diseases characterised by distortion of lung interstitium. Patients with mutations in surfactant-processing genes, such as surfactant protein C ( SFTPC ), surfactant protein A1 and A2 ( SFTPA1 and A2 ), ATP binding cassette A3 ( ABCA3 ) and Hermansky-Pudlak syndrome ( HPS1 , 2 and 4 ), develop progressive pulmonary fibrosis, often culminating in fatal respiratory insufficiency. Although many mutations have been described, little is known about the optimal treatment strategy for fibrotic interstitial pneumonia patients with surfactant-processing mutations...
September 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950308/interstitial-pneumonia-with-autoimmune-features-a-new-classification-still-on-the-move
#11
EDITORIAL
Lorenzo Cavagna, Miguel A Gonzalez Gay, Yannick Allanore, Marco Matucci-Cerinic
No abstract text is available yet for this article.
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950307/cell-matrix-interactions-in-lung-disease-and-regeneration-ers-lung-science-conference-2018-report
#12
EDITORIAL
Silke Meiners, Clare Lloyd, Rachel C Chambers
No abstract text is available yet for this article.
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950306/matrix-abnormalities-in-pulmonary-fibrosis
#13
REVIEW
Chandak Upagupta, Chiko Shimbori, Rahmah Alsilmi, Martin Kolb
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by excessive scarring, which leads to increased tissue stiffness, loss in lung function and ultimately death. IPF is characterised by progressive fibroblast and myofibroblast proliferation, and extensive deposition of extracellular matrix (ECM). Myofibroblasts play a key role in ECM deposition. Transforming growth factor (TGF)-β1 is a major growth factor involved in myofibroblast differentiation, and the creation of a profibrotic microenvironment...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950305/the-consequence-of-matrix-dysfunction-on-lung-immunity-and-the-microbiome-in-copd
#14
Tracy Hussell, Sylvia Lui, Christopher Jagger, David Morgan, Oliver Brand
The pulmonary extracellular matrix (ECM) is a complex network of proteins which primarily defines tissue architecture and regulates various biochemical and biophysical processes. It is a dynamic system comprising two main structures (the interstitial matrix and the basement membrane) which undergo continuous, yet highly regulated, remodelling. This remodelling process is essential for tissue homeostasis and uncontrolled regulation can lead to pathological states including chronic obstructive pulmonary disease (COPD)...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950304/how-bacteria-hack-the-matrix-and-dodge-the-bullets-of-immunity
#15
REVIEW
Magnus Paulsson, Kristian Riesbeck
Haemophilus influenzae , Moraxella catarrhalis and Pseudomonas aeruginosa are common Gram-negative pathogens associated with an array of pulmonary diseases. All three species have multiple adhesins in their outer membrane, i.e. surface structures that confer the ability to bind to surrounding cells, proteins or tissues. This mini-review focuses on proteins with high affinity for the components of the extracellular matrix such as collagen, laminin, fibronectin and vitronectin. Adhesins are not structurally related and may be lipoproteins, transmembrane porins or large protruding trimeric auto-transporters...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29950303/the-multifaceted-roles-of-the-matrikine-pro-gly-pro-in-pulmonary-health-and-disease
#16
REVIEW
Dhiren F Patel, Robert J Snelgrove
Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability. Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29898905/tuberculosis-elimination-where-are-we-now
#17
REVIEW
Alberto Matteelli, Adrian Rendon, Simon Tiberi, Seif Al-Abri, Constantia Voniatis, Anna Cristina C Carvalho, Rosella Centis, Lia D'Ambrosio, Dina Visca, Antonio Spanevello, Giovanni Battista Migliori
Tuberculosis (TB) still represents a major public health issue in spite of the significant impact of the efforts made by the World Health Organization (WHO) and partners to improve its control. In 2014 WHO launched a new global strategy (End TB) with a vision of a world free of TB, and a 2035 goal of TB elimination (defined as less than one incident case per million). The aim of this article is to summarise the theoretical bases of the End TB Strategy and to analyse progresses and persistent obstacles on the way to TB elimination...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29898904/should-i-stay-or-should-i-go-copd-and-air-travel
#18
REVIEW
Begum Ergan, Metin Akgun, Angela Maria Grazia Pacilli, Stefano Nava
Chronic obstructive pulmonary disease (COPD) is a challenging respiratory problem throughout the world. Although survival is prolonged with new therapies and better management, the magnitude of the burden resulting from moderate-to-severe disease is increasing. One of the major aims of the disease management is to try to break the vicious cycle of patients being homebound and to promote an active lifestyle. A fundamental component of active daily life is, of course, travelling. Today, the world is getting smaller with the option of travelling by air...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29875138/copd-stands-for-complex-obstructive-pulmonary-disease
#19
REVIEW
Sarah Houben-Wilke, Ingrid M Augustin, Jan H Vercoulen, Dirk van Ranst, Eline Bij de Vaate, Johan B Wempe, Martijn A Spruit, Emiel F M Wouters, Frits M E Franssen
Chronic obstructive pulmonary disease (COPD) has extensively been reported as a complex disease affecting patients' health beyond the lungs with a variety of intra- and extrapulmonary components and considerable variability between individuals. This review discusses the assessment of this complexity and underlines the importance of transdisciplinary management programmes addressing the physical, emotional and social health of the individual patient.COPD management is challenging and requires advanced, sophisticated strategies meeting the patient's individual needs...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29875137/acellular-human-lung-scaffolds-to-model-lung-disease-and-tissue-regeneration
#20
REVIEW
Sarah E Gilpin, Darcy E Wagner
Recent advances in whole lung bioengineering have opened new doors for studying lung repair and regeneration ex vivo using acellular human derived lung tissue scaffolds. Methods to decellularise whole human lungs, lobes or resected segments from normal and diseased human lungs have been developed using both perfusion and immersion based techniques. Immersion based techniques allow laboratories without access to intact lobes the ability to generate acellular human lung scaffolds. Acellular human lung scaffolds can be further processed into small segments, thin slices or extracellular matrix extracts, to study cell behaviour such as viability, proliferation, migration and differentiation...
June 30, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
journal
journal
30811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"