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European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/29779901/white-matter-disruptions-in-patients-with-bipolar-disorder
#1
Lucija Abramovic, Marco P M Boks, Annabel Vreeker, Sanne Verkooijen, Annet H van Bergen, Roel A Ophoff, René S Kahn, Neeltje E M van Haren
Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics...
May 17, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29724638/placid-study-a-randomized-trial-comparing-the-efficacy-and-safety-of-inhaled-loxapine-versus-intramuscular-aripiprazole-in-acutely-agitated-patients-with-schizophrenia-or-bipolar-disorder
#2
Luis San, Gemma Estrada, Natalia Oudovenko, Francisco Montañés, Natalia Dobrovolskaya, Olga Bukhanovskaya, Mikhail Popov, Eduard Vieta
The aim of the study was to investigate the efficacy and safety of inhaled loxapine compared with the intramuscular (IM) antipsychotic aripiprazole in acutely agitated patients with schizophrenia or bipolar I disorder. PLACID was an assessor-blind, parallel-group trial conducted in 23 centres in the Czech Republic, Germany, Spain, and Russia. Patients (aged 18-65 years) diagnosed with schizophrenia or bipolar I disorder experiencing acute agitation (Clinical Global Impression [CGI]-Severity score ≥ 4) while hospitalized or attending an emergency room were randomized to receive up to two doses of inhaled loxapine 9...
May 1, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29705023/lower-dopamine-tone-in-the-striatum-is-associated-with-higher-body-mass-index
#3
Ying Lee, Nils B Kroemer, Liane Oehme, Bettina Beuthien-Baumann, Thomas Goschke, Michael N Smolka
Existing literature suggests that striatal dopamine (DA) tone may be altered in individuals with higher body mass index (BMI), but evidence accrued so far only offers an incomplete view of their relationship. Here, we characterized striatal DA tone using more comprehensive measures within a larger sample than previously reported. In addition, we explored if there was a relationship between striatal DA tone and disinhibited eating. 60 healthy participants underwent a 6-[18 F]fluoro-L-3,4-dihydroxyphenylalanine (18 F-DOPA) positron emission tomography (PET) scan...
April 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29705022/comorbid-thyroid-disease-in-patients-with-major-depressive-disorder-results-from-the-european-group-for-the-study-of-resistant-depression-gsrd
#4
Gernot Fugger, Markus Dold, Lucie Bartova, Alexander Kautzky, Daniel Souery, Julien Mendlewicz, Alessandro Serretti, Joseph Zohar, Stuart Montgomery, Richard Frey, Siegfried Kasper
This multicenter study of the European Group for the Study of Resistant Depression (GSRD) aimed to explore the association between major depressive disorder (MDD) and comorbid thyroid disease. A total number of 1410 patients` characteristics in terms of demographic and clinical information were compared between MDD subjects with and without concurrent thyroid disease using descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses. We determined a point prevalence rate for comorbid hypothyroidism of 13...
April 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29703646/striatal-dopamine-release-and-impaired-reinforcement-learning-in-adults-with-22q11-2-deletion-syndrome
#5
Esther D A van Duin, Zuzana Kasanova, Dennis Hernaus, Jenny Ceccarini, Alexander Heinzel, Felix Mottaghy, Siamak Mohammadkhani-Shali, Oliver Winz, Michael Frank, Merrit C H Beck, Jan Booij, Inez Myin-Germeys, Thérèse van Amelsvoort
22q11.2 deletion syndrome (22q11DS) is a genetic disorder caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk for developing psychosis. The catechol-O-methyltransferase (COMT) gene is located in the deleted region and involved in dopamine (DA) breakdown. Impaired reinforcement learning (RL) is a recurrent feature in psychosis and thought to be related to abnormal striatal DA function. This study aims to examine RL and the potential association with striatal DA-ergic neuromodulation in 22q11DS...
April 24, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29703645/psilocybin-modulates-functional-connectivity-of-the-amygdala-during-emotional-face-discrimination
#6
O Grimm, R Kraehenmann, K H Preller, E Seifritz, F X Vollenweider
Recent studies suggest that the antidepressant effects of the psychedelic 5-HT2A receptor agonist psilocybin are mediated through its modulatory properties on prefrontal and limbic brain regions including the amygdala. To further investigate the effects of psilocybin on emotion processing networks, we studied for the first-time psilocybin's acute effects on amygdala seed-to-voxel connectivity in an event-related face discrimination task in 18 healthy volunteers who received psilocybin and placebo in a double-blind balanced cross-over design...
April 24, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29699723/delayed-increase-of-thrombocyte-levels-after-a-single-sub-anesthetic-dose-of-ketamine-a-randomized-trial
#7
Lejla Colic, Marie Woelfer, Merima Colic, Anna Linda Leutritz, Thomas Liebe, Luisa Fensky, Zumrut Duygu Sen, Meng Li, Juliane Hoffmann, Moritz A Kretzschmar, Berend Isermann, Martin Walter
Recently, ketamine has been investigated as a potential antidepressant option for treatment resistant depression. Unlike traditional drugs, it yields immediate effects, most likely via increased glutamatergic transmission and synaptic plasticity. However, ketamine administration in humans is systemic and its long-term impact on blood parameters has not yet been described in clinical studies. Here we investigated potential sustained effects of ketamine administration (0.5 mg/kg ketamine racemate) on hematological and biochemical values in plasma and serum in a randomized double-blinded study...
April 23, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29655506/letter-to-the-editor-response-to-costa-et-al
#8
LETTER
Andrew Thompson, Lynn Owens, Paul Richardson, Munir Pirmohamed
No abstract text is available yet for this article.
April 12, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29653743/functional-connectivity-of-the-ventral-tegmental-area-and-avolition-in-subjects-with-schizophrenia-a-resting-state-functional-mri-study
#9
Giulia Maria Giordano, Mario Stanziano, Michele Papa, Armida Mucci, Anna Prinster, Andrea Soricelli, Silvana Galderisi
Avolition, a deficit in goal-directed behavior, is a key aspect of negative symptoms. It is highly prevalent in schizophrenia and is associated to poor functional outcome and to measures of real life motivation, indicating that central to the concept is the lack of interest and motivation. In this study we tested the hypothesis that avolition is related to altered connectivity within dopaminergic cortico-striatal circuits involved in motivation processes. Since dopamine input to these circuits derives mostly from the ventro-tegmental area (VTA), we investigated the relationships between the resting-state functional connectivity (RS-FC) of the VTA and avolition in twenty-six subjects with schizophrenia (SCZ), treated with second-generation antipsychotics only, compared to twenty-two healthy controls (HC)...
April 10, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29653742/neurocognitive-correlates-of-medication-induced-addictive-behaviours-in-parkinson-s-disease-a-systematic-review
#10
REVIEW
Andrew Dawson, Nadeeka N Dissanayaka, Andrew Evans, Antonio Verdejo-Garcia, Trevor T J Chong, Giuseppe Frazzitta, Davide Ferrazzoli, Paola Ortelli, Murat Yücel, Adrian Carter
Dopaminergic medication can induce severe addictive behaviours (e.g., pathological gambling) in susceptible Parkinson's disease (PD) patients. It is still unknown which particular neurocognitive processes become exacerbated or dysfunctional in PD patients with addictive behaviours. We sought to systematically review the relevant literature to identity potential neurocognitive correlates of medication-induced addictive behaviours in PD. We framed our review around neurocognitive processes central to four dominant accounts of substance addiction: 'aberrant learning', 'incentive sensitization', 'impulsivity to compulsivity' and 'impaired response inhibition and salience attribution'...
April 10, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29650294/increased-methylation-at-an-unexplored-glucocorticoid-responsive-element-within-exon-1-d-of-nr3c1-gene-is-related-to-anxious-depressive-disorders-and-decreased-hippocampal-connectivity
#11
Helena Palma-Gudiel, Aldo Córdova-Palomera, Cristian Tornador, Carles Falcón, Núria Bargalló, Gustavo Deco, Lourdes Fañanás
Among the major psychiatric disorders, anxious-depressive disorders stand out as one of the more prevalent and more frequently associated with hypothalamic-pituitary-adrenal (HPA) axis abnormalities. Methylation at the exon 1F of the glucocorticoid receptor gene NR3C1 has been associated with both early stress exposure and risk for developing a psychiatric disorder; however, other NR3C1 promoter regions have been underexplored. Exon 1D emerges as a suggestive new target in stress-related disorders epigenetically sensitive to early adversity...
April 9, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29602597/baseline-serum-vascular-endothelial-growth-factor-levels-predict-treatment-response-to-antipsychotic-medication-in-patients-with-schizophrenia
#12
Wenhuan Xiao, Qiongqiong Zhan, Fei Ye, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
Vascular endothelial growth factor (VEGF) is implicated in angiogenesis, blood flow, and neuroplasticity, which have previously been shown to contribute to schizophrenia and the mechanisms of action of antipsychotic medication. The aim of the present study was to investigate whether baseline serum VEGF levels predict treatment responses to antipsychotic medication. Drug-free adults with schizophrenia were administered monotherapy with atypical antipsychotic drugs for 6 weeks. Participants' psychiatric symptoms were assessed using the positive and negative symptom scale (PANSS) before and after treatment...
March 27, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29571967/functional-mechanism-of-asp5736-a-selective-serotonin-5-ht-5a-receptor-antagonist-with-potential-utility-for-the-treatment-of-cognitive-dysfunction-in-schizophrenia
#13
Mayako Yamazaki, Noriyuki Yamamoto, Junko Yarimizu, Mayuko Okabe, Ai Moriyama, Masako Furutani, Monica M Marcus, Torgny H Svensson, Katsuya Harada
The 5-HT5A receptor is arguably the least understood 5-HT receptor. Despite widespread expression in human and rodent brains it lacks specific ligands. Our previous results suggest that 5-HT5A receptor antagonists may be effective against cognitive impairment in schizophrenia. In this study, using behavioral, immunohistochemical, electrophysiological and microdialysis techniques, we examined the mechanism by which ASP5736, a novel and selective 5-HT5A receptor antagonist, exerts a positive effect in animal models of cognitive impairment...
March 20, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29571966/effects-of-the-antipsychotics-haloperidol-clozapine-and-aripiprazole-on-the-dendritic-spine
#14
Manabu Takaki, Masafumi Kodama, Yutaka Mizuki, Hiroki Kawai, Bunta Yoshimura, Makiko Kishimoto, Shinji Sakamoto, Yuko Okahisa, Norihito Yamada
Three types of antipsychotics, typical (e.g. haloperidol), atypical (e.g. clozapine), and dopamine partial agonist (e.g. aripiprazole), are administered for treatment of schizophrenia. These antipsychotics have different efficacy and side-effect profiles. We investigated whether aripiprazole, clozapine, and haloperidol differentially regulate the dendritic spine through the AKT-GSK-3 beta cascade. Dissociated cortical neurons from Sprague-Dawley rats were prepared and cultured for 28 days. Aripiprazole, clozapine, or haloperidol was administered to the rat cortical neurons...
March 20, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29567399/the-safety-tolerability-and-pharmacokinetics-of-bi-409306-a-novel-and-potent-pde9-inhibitor-overview-of-three-phase-i-randomised-trials-in-healthy-volunteers
#15
Viktoria Moschetti, Maria Kim, Michael Sand, Glen Wunderlich, Grit Andersen, Ulrich Feifel, In-Jin Jang, Wolfgang Timmer, Holger Rosenbrock, Katja Boland
Safety, tolerability and pharmacokinetics of BI 409306, a potent and selective phosphodiesterase 9A inhibitor, were assessed in healthy subjects in three Phase I, within-dose group, double-blind trials. Trial 1 randomised young and elderly subjects to receive BI 409306 25, 50, 100 mg, placebo once daily (OD) or BI 409306 50 mg twice daily (young) for 14 days. Trial 2 randomised young poor metabolisers (PM) of cytochrome P450 isoform 2C19 (CYP2C19) and elderly subjects to receive BI 409306 25, 50 mg or placebo OD for 14 days...
March 19, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29551439/the-need-for-patient-tailored-dosing-of-baclofen-in-future-clinical-trials-%C3%A2
#16
LETTER
Marie Costa, Benjamin Rolland, Patrizia Carrieri
No abstract text is available yet for this article.
May 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29519609/chronic-treatment-with-urb597-ameliorates-post-stress-symptoms-in-a-rat-model-of-ptsd
#17
Sharon Fidelman, Tomer Mizrachi Zer-Aviv, Rachel Lange, Cecilia J Hillard, Irit Akirav
Activating the endocannabinoid system has become a major focus in the search for novel therapeutics for anxiety and deficits in fear extinction, two defining features of PTSD. We examined whether chronic treatment with the fatty acid amide hydrolase (FAAH) inhibitor URB597 (0.2, 0.3, 0.4 mg/kg, i.p.) or the CB1/2 receptor agonist WIN55,212-2 (0.25, 0.5 mg/kg, i.p.) injected for 3 weeks to rats exposed to the shock and reminders model of PTSD would attenuate post-stress symptoms and affect basolateral amygdala (BLA) and CA1 CB1 receptors...
May 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29525411/can-we-increase-the-speed-and-efficacy-of-antidepressant-treatments-part-ii-glutamatergic-and-rna-interference-strategies
#18
REVIEW
F Artigas, P Celada, A Bortolozzi
In the second part we focus on two treatment strategies that may overcome the main limitations of current antidepressant drugs. First, we review the experimental and clinical evidence supporting the use of glutamatergic drugs as fast-acting antidepressants. Secondly, we review the involvement of microRNAs (miRNAs) in the pathophysiology of major depressive disorder (MDD) and the use of small RNAs (e.g.., small interfering RNAs or siRNAs) to knockdown genes in monoaminergic and non-monoaminergic neurons and induce antidepressant-like responses in experimental animals...
April 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29519610/a-novel-mechanism-of-depression-role-for-connexins
#19
REVIEW
Cong-Yuan Xia, Zhen-Zhen Wang, Tohru Yamakuni, Nai-Hong Chen
Major depressive disorder (MDD) is a chronic and debilitating illness that affects over 350 million people worldwide; however, current treatments have failed to cure or prevent the progress of depression. Increasing evidence suggests a crucial role for connexins in MDD. In this review, we have summarised recent accomplishments regarding the role of connexins, gap junctions, and hemichannels in the aetiology of MDD, and discussed the limitations of current research. A blockage of gap junctions or hemichannels induces depressive behaviour...
April 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29482974/cognitive-predictors-of-illness-course-at-12-months-after-first-episode-of-depression
#20
M Vicent-Gil, A Keymer-Gausset, M Serra-Blasco, M Carceller-Sindreu, J de Diego-Adeliño, J Trujols, M Mur, V Pérez, E Alvarez, N Cardoner, M J Portella
Major Depressive Disorder (MDD) entails cognitive dysfunction in many cognitive domains, but it is still uncertain whether such deficits are present in the early stages. The purpose of the study is to determine the cognitive performance in first episode depression (FED) exploring the presence of different cognitive profiles, and the role of cognition in FED at baseline and long-term. Ninety subjects (18-50 years) were included, 50 patients with a FED and 40 healthy controls. Participants were assessed with a neuropsychological battery, covering language, attention, verbal memory, processing speed and executive domains...
April 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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