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European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/28089652/hippocampal-prefrontal-connectivity-as-a-translational-phenotype-for-schizophrenia
#1
REVIEW
Florian Bähner, Andreas Meyer-Lindenberg
Finding novel biological targets in psychiatry has been difficult, partly because current diagnostic categories are not defined by pathophysiology and difficult to model in animals. The study of species-conserved systems-level mechanisms implicated in psychiatric disease could be a promising strategy to address some of these difficulties. Altered hippocampal-prefrontal (HC-PFC) connectivity during working memory (WM) processing is a candidate for such a translational phenotype as it has been repeatedly associated with impaired cognition in schizophrenia patients and animal models for psychiatric risk factors...
January 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28063625/regulation-of-insulin-receptor-phosphorylation-in-the-brains-of-prenatally-stressed-rats-new-insight-into-the-benefits-of-antidepressant-drug-treatment
#2
Katarzyna Głombik, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
A growing body of evidence supports the involvement of disturbances in the brain insulin pathway in the pathogenesis of depression. On the other hand, data concerning the impact of antidepressant drug therapy on brain insulin signaling remain scare and insufficient. We determinated the influence of chronic treatment with antidepressant drugs (imipramine, fluoxetine and tianeptine) on the insulin signaling pathway of the brain of adult prenatally stressed rats. 3-month-old prenatally stressed and control rats were treated for 21 days with imipramine, fluoxetine or tianeptine (10mg/kg/day i...
January 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28062203/semi-mechanistic-computer-simulation-of-psychotic-symptoms-in-schizophrenia-with-a-model-of-a-humanized-cortico-striatal-thalamocortical-loop
#3
Athan Spiros, Patrick Roberts, Hugo Geerts
Despite new insights into the pathophysiology of schizophrenia and clinical trials with highly selective drugs, no new therapeutic breakthroughs have been identified. We present a semi-mechanistic Quantitative Systems Pharmacology (QSP) computer model of a biophysically realistic cortical-striatal-thalamo-cortical loop. The model incorporates the direct, indirect and hyperdirect pathway of the basal ganglia and CNS drug targets that modulate neuronal firing, based on preclinical data about their localization and coupling to voltage-gated ion channels...
January 3, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28049558/neonatal-handling-enduringly-decreases-anxiety-and-stress-responses-and-reduces-hippocampus-and-amygdala-volume-in-a-genetic-model-of-differential-anxiety-behavioral-volumetric-associations-in-the-roman-rat-strains
#4
Cristóbal Río-Álamos, Ignasi Oliveras, Maria Antonietta Piludu, Cristina Gerbolés, Toni Cañete, Gloria Blázquez, Silvia Lope-Piedrafita, Esther Martínez-Membrives, Rafael Torrubia, Adolf Tobeña, Alberto Fernández-Teruel
The hippocampus and amygdala have been proposed as key neural structures related to anxiety. A more active hippocampus/amygdala system has been related to greater anxious responses in situations involving conflict/novelty. The Roman Low- (RLA) and High-avoidance (RHA) rat lines/strains constitute a genetic model of differential anxiety. Relative to RHA rats, RLA rats exhibit enhanced anxiety/fearfulness, augmented hippocampal/amygdala c-Fos expression following exposure to novelty/conflict, increased hippocampal neuronal density and higher endocrine responses to stress...
December 31, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28043732/interactions-between-cannabidiol-and-%C3%AE-9-thc-following-acute-and-repeated-dosing-rebound-hyperactivity-sensorimotor-gating-and-epigenetic-and-neuroadaptive-changes-in-the-mesolimbic-pathway
#5
Stephanie M Todd, Cilla Zhou, David J Clarke, Tariq W Chohan, Dilara Bahceci, Jonathon C Arnold
The evidence base for the use of medical cannabis preparations containing specific ratios of cannabidiol (CBD) and Δ(9)-tetrahydrocannabinol (THC) is limited. While there is abundant data on acute interactions between CBD and THC, few studies have assessed the impact of their repeated co-administration. We previously reported that CBD inhibited or potentiated the acute effects of THC dependent on the measure being examined at a 1:1 CBD:THC dose ratio. Further, CBD decreased THC effects on brain regions involved in memory, anxiety and body temperature regulation...
December 30, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28012706/anything-goes-regulation-of-the-neural-processes-underlying-response-inhibition-in-tbi-patients
#6
Laura Moreno-López, Anne E Manktelow, Barbara J Sahakian, David K Menon, Emmanuel A Stamatakis
Despite evidence for beneficial use of methylphenidate in response inhibition, no studies so far have investigated the effects of this drug in the neurobiology of inhibitory control in traumatic brain injury (TBI), even though impulsive behaviours are frequently reported in this patient group. We investigated the neural basis of response inhibition in a group of TBI patients using functional magnetic resonance imaging and a stop-signal paradigm. In a randomised double-blinded crossover study, the patients received either a single 30mg dose of methylphenidate or placebo and performed the stop-signal task...
December 21, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27986355/the-prolyl-oligopeptidase-inhibitor-ipr19-ameliorates-cognitive-deficits-in-mouse-models-of-schizophrenia
#7
Roger Prades, Eva Munarriz-Cuezva, Leyre Urigüen, Itziar Gil-Pisa, Lídia Gómez, Laura Mendieta, Soledad Royo, Ernest Giralt, Teresa Tarragó, J Javier Meana
Cognitive deficits are considered a key feature of schizophrenia, and they usually precede the onset of the illness and continue after psychotic symptoms appear. Current antipsychotic drugs have little or no effect on the cognitive deficits of this disorder. Prolyl oligopeptidase (POP) is an 81-kDa monomeric serine protease that is expressed in brain and other tissues. POP inhibitors have shown neuroprotective, anti-amnesic and cognition-enhancing properties. Here we studied the potential of IPR19, a new POP inhibitor, for the treatment of the cognitive symptoms related to schizophrenia...
December 13, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27939135/chronic-lurasidone-treatment-normalizes-gabaergic-marker-alterations-in-the-dorsal-hippocampus-of-mice-exposed-to-prenatal-immune-activation
#8
A Luoni, J Richetto, L Longo, M A Riva
Prenatal maternal infection represents a risk factor for the development of psychopathologic conditions later in life. Clinical evidence is also supported by animal models in which the vulnerability to develop a schizophrenic-like phenotype likely originates from inflammatory processes as early as in the womb. Prenatal immune challenge, for example, induces a variety of long-term behavioral alterations in mice, such as deficits in recognition and spatial working memory, perseverative behaviors and social impairments, which are relevant to different symptom clusters of schizophrenia...
December 8, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27955831/sedative-effect-of-clozapine-is-a-function-of-5-ht2a-and-environmental-novelty
#9
Radhika S Joshi, Rolen Quadros, Michael Drumm, Rupasri Ain, Mitradas M Panicker
Antipsychotic drugs are the mainstay in the treatment of schizophrenia and bipolar disorder. However, antipsychotics often exhibit sedation or activity suppression among many other side effects, and the factors that influence them remain poorly understood. We now show, using a 5-HT2A knockout (Htr2a(-/-)) mouse, that environmental circumstances can affect suppression of activity induced by the atypical antipsychotic- Clozapine. We observed that Htr2a(-/-) mice were more resistant to Clozapine-induced suppression of activity (CISA) and this behaviour was dependent on the environment being 'novel'...
December 7, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27955830/inverse-agonists-what-do-they-mean-for-psychiatry
#10
David Nutt, Stephen Stahl, Pierre Blier, Filippo Drago, Joseph Zohar, Sue Wilson
The nomenclature of drugs is a critical aspect of science, since it can direct research and optimize treatment choices. Traditionally drugs acting on CNS receptors have been classified as either agonists or antagonists. Recently a new class of ligand, the inverse agonist, has been identified in some receptor systems. Inverse agonists have opposite actions to those of agonists but the effects of both of these can be blocked by antagonists. Pimavanserin is a new 5-HT2A receptor acting drug that has been given market authorization for psychosis in Parkinson׳s disease...
December 7, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27939254/early-introduction-of-clozapine-after-neuroleptic-malignant-syndrome-may-prevent-malignant-catatonia-a-case-report
#11
LETTER
G van Rooijen, M Strypet, A Maat, D S Scheepens, M S Oudijn, K E Klopper, D Denys
No abstract text is available yet for this article.
December 6, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27919523/adjunctive-minocycline-for-schizophrenia-a-meta-analysis-of-randomized-controlled-trials
#12
Ying-Qiang Xiang, Wei Zheng, Shi-Bin Wang, Xin-Hu Yang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Deanna L Kelly, Wei-Ying Xu, Yu-Tao Xiang
This study aimed to conduct a meta-analysis of the efficacy and safety of adjunctive minocycline for schizophrenia. Randomized controlled trials (RCTs) comparing adjunctive minocycline with placebo in patients with schizophrenia were included in the meta-analysis. Two independent investigators extracted and synthesized data. Standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) and the number-needed-to-harm (NNH) were calculated. Eight RCTs with 548 schizophrenia patient including 286 (52...
December 2, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27914751/the-association-between-premorbid-cognitive-ability-and-social-functioning-and-suicide-among-young-men-a-historical-prospective-cohort-study
#13
Mark Weiser, Daphna Fenchel, Nomi Werbeloff, Shira Goldberg, Eyal Fruchter, Abraham Reichenberg, Shimon Burshtein, Matthew Large, Michael Davidson, Gad Lubin
Previous studies have found associations between low cognitive ability and later completed suicide. The aim of this study was to examine the association between cognitive ability and social functioning in adolescence, and later completed suicide in a large population-based longitudinal study. Data from the Israeli Draft Board Register for 634,655 Israeli male adolescents aged 16 and 17 was linked to a causes-of-death data registry, with a mean follow-up of 10.6 years for completed suicide. Our results show that in males without a psychiatric diagnosis, both low (adjusted HR=1...
November 30, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27908572/significant-treatment-effect-of-add-on-ketamine-anesthesia-in-electroconvulsive-therapy-in-depressive-patients-a-meta-analysis
#14
Dian-Jeng Li, Fu-Chiang Wang, Che-Sheng Chu, Tien-Yu Chen, Chia-Hung Tang, Wei-Cheng Yang, Philip Chik-Keung Chow, Ching-Kuan Wu, Ping-Tao Tseng, Pao-Yen Lin
Add-on ketamine anesthesia in electroconvulsive therapy (ECT) has been studied in depressive patients in several clinical trials with inconclusive findings. Two most recent meta-analyses reported insignificant findings with regards to the treatment effect of add-on ketamine anesthesia in ECT in depressive patients. The aim of this study is to update the current evidence and investigate the role of add-on ketamine anesthesia in ECT in depressive patients via a systematic review and meta-analysis. We performed a thorough literature search of the PubMed and ScienceDirect databases, and extracted all relevant clinical variables to compare the antidepressive outcomes between add-on ketamine anesthesia and other anesthetics in ECT...
November 28, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27890541/the-expression-of-plasticity-related-genes-in-an-acute-model-of-stress-is-modulated-by-chronic-desipramine-in-a-time-dependent-manner-within-medial-prefrontal-cortex
#15
Nicoletta Nava, Giulia Treccani, Heidi Kaastrup Müller, Maurizio Popoli, Gregers Wegener, Betina Elfving
It is well established that stress plays a major role in the pathogenesis of neuropsychiatric diseases. Stress-induced alteration of synaptic plasticity has been hypothesized to underlie the morphological changes observed by neuroimaging in psychiatric patients in key regions such as hippocampus and prefrontal cortex (PFC). We have recently shown that a single acute stress exposure produces significant short-term alterations of structural plasticity within medial PFC. These alterations were partially prevented by previous treatment with chronic desipramine (DMI)...
November 24, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27890540/association-of-plasma-calcium-concentrations-with-alcohol-craving-new-data-on-potential-pathways
#16
Rilana Schuster, Anne Koopmann, Martin Grosshans, Iris Reinhard, Rainer Spanagel, Falk Kiefer
Recently, calcium was suggested to be the active moiety of acamprosate. We examined plasma calcium concentrations in association with severity of alcohol dependence and its interaction with regulating pathways and alcohol craving in alcohol-dependent patients. 47 inpatient alcohol-dependent patients undergoing detoxification treatment underwent laboratory testing, including calcium, sodium, liver enzymes as well as serum concentrations of calcitonin, parathyroid hormone and vitamin D. The psychometric dimension of craving was analyzed with the Obsessive Compulsive Drinking Scale (OCDS)...
November 24, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27890539/the-potential-of-individual-patient-data-for-research-on-antidepressant-safety-and-efficacy
#17
LETTER
Ymkje Anna de Vries, Annelieke M Roest, Peter de Jonge
No abstract text is available yet for this article.
November 24, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27887861/bias-in-the-reporting-of-harms-in-clinical-trials-of-second-generation-antidepressants-the-tip-of-the-iceberg
#18
Alain Braillon, Florian Naudet
Serious adverse events are poorly reported in clinical trials of second-generation antidepressants. Moreover some key opinion leaders (eg. in France) deliberately failed to warn against them. The gross distortions of antidepressants' benefit:harm ratio in adolescents showed evidence that open science (ie access to de-identified individual patient data for re-analyses) is a mandatory prerequisite for a trustworthy science.
November 22, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27887860/modeling-the-development-of-panic-disorder-with-interoceptive-conditioning
#19
Klara De Cort, Mathias Schroijen, Rene Hurlemann, Suzanne Claassen, Jojanneke Hoogenhout, Omer Van den Bergh, Liesbet Goossens, Ilse Van Diest, Koen Schruers
Panic disorder is characterized by the paroxysmal occurrence and fear of bodily symptoms. In recent years it has been proposed that patients "learn" to fear cardiorespiratory sensations through interoceptive conditioning. This study sought to model the initial stage of this process in healthy volunteers (N=44) using mild cardiac sensations. An additional aim was to explore whether anxiety sensitivity - a known risk factor for panic disorder - modulates such interoceptive learning. Infusions of pentagastrin and saline were used to manipulate the presence versus absence of cardiac sensations, respectively, and served as conditioned stimuli in a differential interoceptive conditioning paradigm...
November 22, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27887859/olanzapine-modulation-of-long-and-short-range-functional-connectivity-in-the-resting-brain-in-a-sample-of-patients-with-schizophrenia
#20
Wenbin Guo, Feng Liu, Jindong Chen, Renrong Wu, Lehua Li, Zhikun Zhang, Jingping Zhao
Treatment effects of antipsychotic drugs on cerebral function are seldom examined. Exploring functional connectivity (FC) in drug-free schizophrenia patients before and after antipsychotic treatment can improve the understanding of antipsychotic drug mechanisms. A total of 17 drug-free patients with recurrent schizophrenia and 24 healthy controls underwent resting-state functional magnetic resonance imaging scans. Long- and short-range FC strengths (FCS) were calculated for each participant. Compared with the controls, the patients at baseline exhibited increased long-range positive FCS (lpFCS) in the bilateral inferior parietal lobule (IPL) and decreased lpFCS in the brain regions of the default-mode network (DMN) regions and sensorimotor circuits of the brain...
November 22, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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