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European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/28237505/stressful-life-events-increase-aggression-and-alcohol-use-in-young-carriers-of-the-gabra2-rs279826-rs279858-a-allele
#1
Evelyn Kiive, Kariina Laas, Mariliis Vaht, Toomas Veidebaum, Jaanus Harro
Research of GABRA2 gene in alcohol use and impulse control suggests its role in aggressive behaviour. The purpose of the present study was to examine the effects of GABRA2 genotype and stressful life events on aggressive behaviour, alcohol use frequency and occurrence of alcohol use disorder in a population representative sample of adolescents followed up from third grade to 25 years of age. The sample consisted of the younger cohort of the longitudinal Estonian Children Personality, Behaviour and Health Study...
February 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28237506/eeg-connectivity-between-the-subgenual-anterior-cingulate-and-prefrontal-cortices-in-response-to-antidepressant-medication
#2
Tabitha A Iseger, Mayuresh S Korgaonkar, J Leon Kenemans, Stuart M Grieve, Chris Baeken, Paul B Fitzgerald, Martijn Arns
Antidepressant medication is the most common treatment for major depressive disorder (MDD), however, the precise working mechanism underlying these treatments remains unclear. Recent neuromodulation treatments demonstrate that direct stimulation of the dorsolateral prefrontal cortex (DLPFC), dorsomedial prefrontal cortex (DMPFC), and subgenual anterior cingulate (sgACC) relate to clinical improvement, suggesting connectivity alterations of the DLPFC-DMPFC-sgACC network to mediate antidepressant response. The international Study to Predict Optimized Treatment in Depression (iSPOT-D) is an international multicentre study that collected EEG data for 1008 MDD patients, randomized to 3 different antidepressant medications (N=447 MDD with complete pre- and post-treatment data and N=336 non-MDD)...
February 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28233670/crhr1-promoter-hypomethylation-an-epigenetic-readout-of-panic-disorder
#3
Christoph Schartner, Christiane Ziegler, Miriam A Schiele, Leonie Kollert, Heike Weber, Peter Zwanzger, Volker Arolt, Paul Pauli, Jürgen Deckert, Andreas Reif, Katharina Domschke
The corticotropin releasing hormone receptor 1 (CRHR1) is crucially involved in the hypothalamic-pituitary-adrenal axis and thus a major regulator of the stress response. CRHR1 gene variation is associated with several mental disorders including anxiety disorders. Studies in rodents have demonstrated epigenetic regulation of CRHR1 gene expression to moderate response to stressful environment. In the present study, we investigated CRHR1 promoter methylation for the first time regarding its role in panic disorder applying a case-control approach (N=131 patients, N=131 controls)...
February 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28190661/the-novel-antipsychotic-drug-brexpiprazole-alone-and-in-combination-with-escitalopram-facilitates-prefrontal-glutamatergic-transmission-via-a-dopamine-d1-receptor-dependent-mechanism
#4
Carl Björkholm, Monica M Marcus, Åsa Konradsson-Geuken, Kent Jardemark, Torgny H Svensson
Brexpiprazole (Rexulti(®)), a novel D2/3 receptor (R) partial agonist, was recently approved as monotherapy for schizophrenia, demonstrating effectiveness against both positive and negative symptoms, and also approved as add-on treatment to antidepressant drugs, inducing a potent antidepressant effect with a faster onset compared to an antidepressant given alone. Moreover, brexpiprazole has demonstrated pro-cognitive effects in preclinical studies. To explore whether the observed effects may be mediated via modulation of prefrontal glutamatergic transmission, we investigated the effect of brexpiprazole, alone and in combination with the SSRI escitalopram, on prefrontal glutamatergic transmission using in vitro electrophysiological intracellular recordings of deep layer pyramidal cells of the rat medial prefrontal cortex (mPFC)...
February 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28187919/dopamine-d3-and-acetylcholine-nicotinic-receptor-heteromerization-in-midbrain-dopamine-neurons-relevance-for-neuroplasticity
#5
Leonardo Bontempi, Paola Savoia, Federica Bono, Chiara Fiorentini, Cristina Missale
Activation of nicotinic acetylcholine receptors (nAChR) promotes the morphological remodeling of cultured dopamine (DA) neurons, an effect requiring functional DA D3 receptors (D3R). The aim of this study was to investigate the mechanisms mediating D3R-nAChR cross-talk in the modulation of DA neuron structural plasticity. By using bioluminescence resonance energy transfer(2) (BRET(2)) and proximity ligation assay (PLA), evidence for the existence of D3R-nAChR heteromers has been obtained. In particular, BRET(2) showed that the D3R directly and specifically interacts with the β2 subunit of the nAChR...
February 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28161247/evidence-based-national-suicide-prevention-taskforce-in-europe-a-consensus-position-paper
#6
Gil Zalsman, Keith Hawton, Danuta Wasserman, Kees van Heeringen, Ella Arensman, Marco Sarchiapone, Vladimir Carli, Cyril Höschl, Petr Winkler, Judit Balazs, György Purebl, Jean Pierre Kahn, Pilar Alejandra Sáiz, Julio Bobes, Doina Cozman, Ulrich Hegerl, Elmārs Rancāns, Gergö Hadlaczky, Chantal Van Audenhove, Haggy Hermesh, Merike Sisask, Armen Melik Peschayan, Nestor Kapusta, Virginja Adomaitiene, Vesta Steibliene, Iwowa Kosiewska, Vsevolod Rozanov, Philp Courtet, Joseph Zohar
No abstract text is available yet for this article.
February 1, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28161246/partial-agonism-at-the-%C3%AE-7-nicotinic-acetylcholine-receptor-improves-attention-impulsive-action-and-vigilance-in-low-attentive-rats
#7
Andrew Hayward, Lisa Adamson, Joanna C Neill
Inattention is a disabling symptom in conditions such as schizophrenia and attention deficit/hyperactivity disorder. Nicotine can improve attention and vigilance, but is unsuitable for clinical use due to abuse liability. Genetic knockout of the α7 nicotinic acetylcholine receptor (nAChR) induces attention deficits therefore selective agonism may improve attention, without the abuse liability associated with nicotine. The α7 nAChR partial agonist encenicline (formerly EVP-6124) enhances memory in rodents and humans...
February 1, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28131675/the-involvement-of-cannabinoids-and-mtor-in-the-reconsolidation-of-an-emotional-memory-in-the-hippocampal-amygdala-insular-circuit
#8
Salman Zubedat, Irit Akirav
Memory reconsolidation is the process in which reactivated long-term memory becomes transiently sensitive to amnesic agents. We evaluated the ability of post reactivation administration of the mTOR inhibitor rapamycin, separately and in combination with the cannabinoid CB1/2 receptor agonist WIN55,212-2 (WIN), given systemically or specifically into the hippocampal CA1 area, basolateral amygdala (BLA) or insular cortex (IC), to reduce inhibitory avoidance fear in rats. Systemic administration of rapamycin after reactivation of fear memory impaired reconsolidation and facilitated extinction...
January 25, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28130001/dried-blood-spot-sampling-in-psychiatry-perspectives-for-improving-therapeutic-drug-monitoring
#9
REVIEW
Lisa C Martial, Rob E Aarnoutse, Martina Mulder, Arnt Schellekens, Roger J M Brüggemann, David M Burger, Aart H Schene, Albert Batalla
Assessment of drug concentrations is indicated to guide dosing of a selected number of drugs used in psychiatry. Conventionally this is done by vena puncture. Novel sampling strategies such as dried blood spot (DBS) sampling have been developed for various drugs, including antipsychotics, antidepressants and mood-stabilizers. DBS sampling is typically performed by means of a finger prick. This method allows for remote sampling, which means that patients are not required to travel to a health care facility. The number of DBS assays for drugs used in psychiatry has increased over the last decade and includes antidepressants (tricyclic and serotonin and/or norepinephrine reuptake inhibitors), mood stabilizers and first- and second-generation antipsychotics...
January 24, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28130000/replicated-association-of-synaptotagmin-syt1-with-adhd-and-its-broader-influence-in-externalizing-behaviors
#10
Renata Basso Cupertino, Jaqueline Bohrer Schuch, Cibele Edom Bandeira, Bruna Santos da Silva, Diego Luiz Rovaris, Djenifer B Kappel, Verônica Contini, Angélica Salatino-Oliveira, Eduardo Schneider Vitola, Rafael Gomes Karam, Mara Helena Hutz, Luis Augusto Rohde, Eugenio Horacio Grevet, Claiton Henrique Dotto Bau, Nina Roth Mota
Attention-Deficit/Hyperactivity Disorder (ADHD) is a common psychiatric disorder, affecting both children and adults. The Soluble N-ethylmaleimide sensitive factor Attachment REceptors (SNARE) complex has been implicated in ADHD pathophysiology since it is a key component of neurotransmitter release events and neurodevelopment processes, and SNPs in this complex have been associated with ADHD. Here we aim to analyze the effects of SNARE complex variants on ADHD susceptibility and its clinical heterogeneity in affected adults...
January 24, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28126401/do-patients-with-bipolar-disorder-and-subsyndromal-symptoms-benefit-from-functional-remediation-a-12-month-follow-up-study
#11
Jose Sanchez-Moreno, Caterina Bonnín, Ana González-Pinto, Benedikt L Amann, Brisa Solé, Vicent Balanzá-Martínez, Celso Arango, Esther Jimenez, Rafael Tabarés-Seisdedos, M Paz Garcia-Portilla, Angela Ibáñez, Jose Manuel Crespo, Jose Luis Ayuso-Mateos, Eduard Vieta, Anabel Martinez-Aran, Carla Torrent
We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to DSM-IV-TR diagnostic criteria, entering a randomized clinical trial, those patients who presented with subsyndromal symptoms were selected based on a method already described by Berk and colleagues was applied. It consists of using the Clinical Global Impression-Bipolar version (CGI-BP) to establish the scores of the Hamilton Depression Rating Scale (HAM-D) and of the Young Mania Rating Scale (YMRS) that correspond with 1 in the CGI-BP...
January 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28119084/effects-of-amphetamine-on-pro-social-ultrasonic-communication-in-juvenile-rats-implications-for-mania-models
#12
K-Alexander Engelhardt, Eberhard Fuchs, Rainer K W Schwarting, Markus Wöhr
Communication is the act of information transfer between sender and receiver. In rats, vocal communication can be studied through ultrasonic vocalizations (USV). 50-kHz USV occur in appetitive situations, most notably juvenile play, likely expressing the sender׳s positive affective state. Such appetitive 50-kHz USV serve important pro-social communicative functions and elicit social exploratory and approach behavior in the receiver. Emission of 50-kHz USV can be induced pharmacologically by the administration of psychostimulant drugs, such as amphetamine...
January 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28119083/methylphenidate-modafinil-and-caffeine-for-cognitive-enhancement-in-chess-a-double-blind-randomised-controlled-trial
#13
Andreas G Franke, Patrik Gränsmark, Alexandra Agricola, Kai Schühle, Thilo Rommel, Alexandra Sebastian, Harald E Balló, Stanislav Gorbulev, Christer Gerdes, Björn Frank, Christian Ruckes, Oliver Tüscher, Klaus Lieb
Stimulants and caffeine have been proposed for cognitive enhancement by healthy subjects. This study investigated whether performance in chess - a competitive mind game requiring highly complex cognitive skills - can be enhanced by methylphenidate, modafinil or caffeine. In a phase IV, randomized, double-blind, placebo-controlled trial, 39 male chess players received 2×200mg modafinil, 2×20mg methylphenidate, and 2×200mg caffeine or placebo in a 4×4 crossover design. They played twenty 15-minute games during two sessions against a chess program (Fritz 12; adapted to players' strength) and completed several neuropsychological tests...
January 21, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28117133/pharmacogenetics-of-ecstasy-cyp1a2-cyp2c19-and-cyp2b6-polymorphisms-moderate-pharmacokinetics-of-mdma-in-healthy-subjects
#14
Patrick Vizeli, Yasmin Schmid, Katharina Prestin, Henriette E Meyer Zu Schwabedissen, Matthias E Liechti
In vitro studies showed that CYP2C19, CYP2B6, and CYP1A2 contribute to the metabolism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) to 3,4-methylenedioxyamphetamine (MDA). However, the role of genetic polymorphisms in CYP2C19, CYP2B6, and CYP1A2 in the metabolism of MDMA in humans is unknown. The effects of genetic variants in these CYP enzymes on the pharmacokinetics and pharmacodynamics of MDMA were characterized in 139 healthy subjects (69 male, 70 female) in a pooled analysis of eight double-blind, placebo-controlled studies...
January 20, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28111239/benefits-and-harms-of-atypical-antipsychotics-for-agitation-in-adults-with-dementia
#15
REVIEW
Martin R Farlow, Tatyana A Shamliyan
We evaluated the most current evidence regarding the benefits and harms of atypical antipsychotics in adults with dementia. In June 2016, following a protocol developed a priori, we systematically searched several databases for published and unpublished data from randomized controlled trials (RCT), observational studies, and meta-analyses; conducted direct meta-analyses using a random effects model; and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group...
January 19, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28109561/lithium-reverses-behavioral-and-axonal-transport-related-changes-associated-with-ank3-bipolar-disorder-gene-disruption
#16
Michael G Gottschalk, Melanie P Leussis, Tillmann Ruland, Klaudio Gjeluci, Tracey L Petryshen, Sabine Bahn
Ankyrin 3 (ANK3) has been implicated as a genetic risk factor for bipolar disorder (BD), however the resulting pathophysiological and treatment implications remain elusive. In a preclinical systems biological approach, we aimed to characterize the behavioral and proteomic effects of Ank3 haploinsufficiency and chronic mood-stabilizer treatment in mice. Psychiatric-related behavior was evaluated with the novelty-suppressed feeding (NSF) paradigm, elevated plus maze (EPM) and a passive avoidance task (PAT). Tandem mass spectrometry (MS(E)) was employed for hippocampal proteome profiling...
January 18, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28108061/benzodiazepine-withdrawal-syndrome-induced-by-thiocolchicoside
#17
LETTER
Marion Lepelley, Michel Mallaret
No abstract text is available yet for this article.
January 17, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27955831/sedative-effect-of-clozapine-is-a-function-of-5-ht2a-and-environmental-novelty
#18
Radhika S Joshi, Rolen Quadros, Michael Drumm, Rupasri Ain, Mitradas M Panicker
Antipsychotic drugs are the mainstay in the treatment of schizophrenia and bipolar disorder. However, antipsychotics often exhibit sedation or activity suppression among many other side effects, and the factors that influence them remain poorly understood. We now show, using a 5-HT2A knockout (Htr2a(-/-)) mouse, that environmental circumstances can affect suppression of activity induced by the atypical antipsychotic- Clozapine. We observed that Htr2a(-/-) mice were more resistant to Clozapine-induced suppression of activity (CISA) and this behaviour was dependent on the environment being 'novel'...
December 7, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27939254/early-introduction-of-clozapine-after-neuroleptic-malignant-syndrome-may-prevent-malignant-catatonia-a-case-report
#19
LETTER
G van Rooijen, M Strypet, A Maat, D S Scheepens, M S Oudijn, K E Klopper, D Denys
No abstract text is available yet for this article.
December 6, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27919523/adjunctive-minocycline-for-schizophrenia-a-meta-analysis-of-randomized-controlled-trials
#20
Ying-Qiang Xiang, Wei Zheng, Shi-Bin Wang, Xin-Hu Yang, Dong-Bin Cai, Chee H Ng, Gabor S Ungvari, Deanna L Kelly, Wei-Ying Xu, Yu-Tao Xiang
This study aimed to conduct a meta-analysis of the efficacy and safety of adjunctive minocycline for schizophrenia. Randomized controlled trials (RCTs) comparing adjunctive minocycline with placebo in patients with schizophrenia were included in the meta-analysis. Two independent investigators extracted and synthesized data. Standard mean differences (SMDs), risk ratio (RR) ±95% confidence intervals (CIs) and the number-needed-to-harm (NNH) were calculated. Eight RCTs with 548 schizophrenia patient including 286 (52...
December 2, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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