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European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology

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https://www.readbyqxmd.com/read/30217553/cb1-receptors-in-the-paraventricular-nucleus-of-the-hypothalamus-modulate-the-release-of-5-ht-and-gaba-to-stimulate-food-intake-in-rats
#1
Ana María Cruz-Martínez, Juan Gabriel Tejas-Juárez, Juan Manuel Mancilla-Díaz, Benjamín Florán-Garduño, Verónica Elsa López-Alonso, Rodrigo Erick Escartín-Pérez
Endocannabinoids and their receptors not only contribute to the control of natural processes of appetite regulation and energy balance but also have an important role in the pathogenesis of obesity. CB1 receptors (CB1R) are expressed in several hypothalamic nuclei, including the paraventricular nucleus (PVN), where induce potent orexigenic responses. Activation of CB1R in the PVN induces hyperphagia by modulating directly or indirectly orexigenic and anorexigenic signals; however, interaction among these mediators has not been clearly defined...
September 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30217552/effects-of-high-dose-baclofen-on-cue-reactivity-in-alcohol-dependence-a-randomized-placebo-controlled-pharmaco-fmri-study
#2
Anne Beck, Patricia Pelz, Robert C Lorenz, Katrin Charlet, Olga Geisel, Andreas Heinz, Torsten Wüstenberg, Christian A Müller
Increased functional brain response towards alcohol-associated stimuli is a neural hallmark of alcohol dependence and a promising target for pharmacotherapy. For the first time, we assessed the effects of individually titrated high-dose baclofen on cue reactivity and functional connectivity in alcohol-dependent (AD) patients in a randomized controlled trial (RCT). We investigated 23 recently detoxified AD patients and 23 matched healthy controls (HC) with a cue reactivity functional magnetic resonance imaging task...
September 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30217551/rapid-acquisition-of-dynamic-control-over-dlpfc-using-real-time-fmri-feedback
#3
Max Alexander Van den Boom, Johan Martijn Jansma, Nick Franciscus Ramsey
It has been postulated that gaining control over activity in the dorsolateral prefrontal cortex (DLPFC), a key region of the working memory brain network, may be beneficial for cognitive performance and treatment of certain psychiatric disorders. Several studies have reported that, with neurofeedback training, subjects can learn to increase DLPFC activity. However, improvement of dynamic control in terms of switching between low and high activity in DLPFC brain states may potentially constitute more effective self-regulation...
September 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30213668/nicotine-improves-probabilistic-reward-learning-in-wildtype-but-not-alpha7-nachr-null-mutants-yet-alpha7-nachr-agonists-do-not-improve-probabilistic-learning
#4
Morgane Milienne-Petiot, Kerin K Higa, Andrea Grim, Debbie Deben, Lucianne Groenink, Elizabeth W Twamley, Mark A Geyer, Jared W Young
Cognitive impairments, e.g., reward learning, are present in various psychiatric disorders and warrant treatment. Improving reward-related learning could synergistically enhance psychosocial treatments and cognition generally. A critical first step is to understand the mechanisms underlying reward learning. The dopamine system has been implicated in such learning, but less known is how indirect activation of this system may affect reward learning. We determined the role of alpha7 nicotinic acetylcholine receptors (nAChR) on a probabilistic reversal learning task (PRLT) in mice that includes reward and punishment...
September 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30201120/saliva-oxytocin-cortisol-and-testosterone-levels-in-adolescent-boys-with-autism-spectrum-disorder-oppositional-defiant-disorder-conduct-disorder-and-typically-developing-individuals
#5
M J Bakker-Huvenaars, C U Greven, P Herpers, E Wiegers, A Jansen, R van der Steen, A E van Herwaarden, A N Baanders, K S Nijhof, F Scheepers, N Rommelse, J C Glennon, J K Buitelaar
The aim of the current study was to compare levels of oxytocin, cortisol, and testosterone in adolescents with either autism spectrum disorder (ASD), or oppositional defiant disorder (ODD)/conduct disorder (CD), and in typically developing individuals (TDI), and relate hormone levels to severity and subtype of aggression and callous-unemotional (CU) traits. Saliva concentrations of oxytocin, cortisol, and testosterone were assessed in 114 male participants (N = 49 ASD, N = 37 ODD/CD, N = 28 TDI,) aged 12-19 years (M = 15...
September 7, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30195575/live-fast-die-young-a-review-on-the-developmental-trajectories-of-adhd-across-the-lifespan
#6
REVIEW
Barbara Franke, Giorgia Michelini, Philip Asherson, Tobias Banaschewski, Andrea Bilbow, Jan K Buitelaar, Bru Cormand, Stephen V Faraone, Ylva Ginsberg, Jan Haavik, Jonna Kuntsi, Henrik Larsson, Klaus-Peter Lesch, J Antoni Ramos-Quiroga, János M Réthelyi, Marta Ribases, Andreas Reif
Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptoms of the disorder and the comorbidities may fluctuate and change over time, and even age of onset in childhood has recently been questioned...
September 5, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30193832/the-need-for-paediatric-registries-to-assess-long-term-brain-effects-of-psychotropic-medications-the-case-of-bipolar-disorder
#7
EDITORIAL
Eduard Vieta, Celso Arango, A John Rush
No abstract text is available yet for this article.
September 4, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30170709/neurological-soft-signs-in-bipolar-disorder-in-comparison-to-healthy-controls-and-schizophrenia-a-meta-analysis
#8
REVIEW
Emre Bora, Özge Akgül, Deniz Ceylan, Ayşegül Özerdem
Neurological soft signs (NSS) are subtle deficits in motor coordination, sensory integration, and sequencing of complex motor acts. Increased NSS is a well-established feature of patients with schizophrenia but a relatively smaller number of studies have investigated NSS in bipolar disorder (BD). Some authors but not others suggested that NSS can distinguish schizophrenia from BD. We conducted a meta-analysis of 18 studies to quantitatively review NSS in BD in comparison to schizophrenia and healthy controls...
August 28, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30153954/loratadine-augments-emotional-blushing
#9
Peter D Drummond, Bronwyn Lester
The aim of this study was to determine whether loratadine, a selective inverse agonist of peripheral histamine H1 receptors, would reduce emotional blushing. Loratadine (10 mg) or placebo was administered orally one hour before 31 healthy participants sang a children's nursery rhyme to evoke embarrassment and blushing. Skin blood flow was monitored via a laser Doppler probe attached to the cheek. Increases in facial blood flow while participants sang were greater in the loratadine than the placebo group (mean increase ± standard deviation 71 ± 52% in the loratadine group versus 35 ± 37%, p = ...
August 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30153953/psychotropic-drugs-use-and-psychotropic-polypharmacy-among-persons-with-alzheimer-s-disease
#10
Kim Orsel, Heidi Taipale, Anna-Maija Tolppanen, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Helga Gardarsdottir, Sirpa Hartikainen
Psychotropic drugs are frequently used for the treatment of behavioural and psychological symptoms of dementia in persons with Alzheimer's disease (AD). Evidence for benefits are limited and concerns have been raised about the safety, especially for the concomitant use of multiple psychotropic drugs. The objective of this study was to investigate prevalence of psychotropic drug and psychotropic polypharmacy (PPP) use and associations with PPP among persons with and without AD, from five years before until four years after AD diagnosis at time points every six months...
August 25, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30146458/differential-anxiety-related-behaviours-and-brain-activation-in-tph2-deficient-female-mice-exposed-to-adverse-early-environment
#11
Charlotte S Auth, Magdalena T Weidner, Sandy Popp, Tatyana Strekalova, Angelika G Schmitt-Böhrer, Daniel LA van den Hove, Klaus-Peter Lesch, Jonas Waider
Anxiety disorders represent one of the most prevalent mental disorders in today's society and early adversity has been identified as major contributor to anxiety-related pathologies. Serotonin (5-hydroxytryptamine, 5-HT) is implicated in mediating the effects of early-life events on anxiety-like behaviours. In order to further elucidate the interaction of genetic predisposition and adversity in early, developmental stages on anxiety-related behaviours, the current study employed tryptophan hydroxylase 2 (Tph2)-deficient female mice, as a model for lifelong brain 5-HT synthesis deficiency...
August 23, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30119924/common-and-distinct-patterns-of-abnormal-cortical-gyrification-in-major-depression-and-borderline-personality-disorder
#12
Malte S Depping, Philipp A Thomann, Nadine D Wolf, Nenad Vasic, Zrinka Sosic-Vasic, Mike M Schmitgen, Fabio Sambataro, Robert C Wolf
Abnormal gray matter volume has been consistently reported in patients with major depressive disorder (MDD), but markers of cortical neurodevelopment have been rarely investigated. Also, it is unclear whether there exist common versus distinct spatial patterns of abnormal cortical development across different disorders presenting with negative emotions and deficient affective regulation. In this study, we used structural MRI at 3T to investigate the local gyrification index (LGI), a marker of fetal/infant neurodevelopment, in adult female patients with MDD (n = 22), in adult female patients with borderline personality disorder (BPD) (n = 17), and in controls (n = 22)...
August 14, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30115553/adjunctive-s-adenosylmethionine-same-in-treating-non-remittent-major-depressive-disorder-an-8-week-double-blind-randomized-controlled-trial
#13
Jerome Sarris, Gerard J Byrne, Chad Bousman, Con Stough, Jenifer Murphy, Patricia MacDonald, Laura Adams, Sonia Nazareth, Georgina Oliver, Lachlan Cribb, Karen Savage, Ranjit Menon, Suneel Chamoli, Michael Berk, Chee Ng, David Mischoulon
There has been increasing interest in nutraceutical augmentation strategies to boost the efficacy of antidepressants. This study assessed whether S-adenosylmethionine (SAMe), a methyl donor that occurs naturally in the body, may be of such benefit. We conducted an 8-week, double-blind RCT in which 107 treatment non-remittent outpatients with DSM-5 diagnosed Major Depressive Disorder (MDD) were randomized to either SAMe or placebo adjunctively to antidepressants. One-carbon cycle nutrients, pertinent single nucleotide polymorphisms (SNPs), and BDNF were also analysed as potential moderators of response...
August 14, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30104163/a-neurobiological-pathway-to-smoking-in-adolescence-ttc12-ankk1-drd2-variants-and-reward-response
#14
Christine Macare, Francesca Ducci, Yuning Zhang, Barbara Ruggeri, Tianye Jia, Marika Kaakinen, Gursharan Kalsi, Pimphen Charoen, Filippo Casoni, Jan Peters, Uli Bromberg, Matthew Hill, Jessica Buxton, Alexandra Blakemore, Juha Veijola, Christian Büchel, Tobias Banaschewski, Arun L W Bokde, Patricia Conrod, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny A Gowland, Andreas Heinz, Bernd Ittermann, Mark Lathrop, Jean-Luc Martinot, Tomáš Paus, Sylvane Desrivières, Marcus Munafò, Marjo-Riitta Järvelin, Gunter Schumann
The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10-4 ) and higher plasma cotinine levels (p = 7...
August 10, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30097249/the-dynamic-relationship-between-insight-and-suicidal-behavior-in-first-episode-psychosis-patients-over-3-year-follow-up
#15
Rosa Ayesa-Arriola, Jose María Pelayo Terán, Javier David López Moríñigo, Manuel Canal Rivero, Esther Setién-Suero, Susana Al-Halabi, Manuel J Cuesta, Anthony S David, Benedicto Crespo-Facorro
Studies have established the high risk of suicide in first episode psychosis (FEP). Between 15% and 26% of FEP patients attempt suicide at least once before their first contact with psychiatric services and 2-5% die from suicide. Also, many patients with schizophrenia spectrum disorders lack insight into having a mental disorder. However, the relationship between insight changes and suicidal behavior in FEP remains poorly understood. In the present study information about suicidal behavior over a 3 years period was available on a cohort of 397 FEP patients, of whom 270 were assessed in the three dimensions of insight (into mental illness, the need for treatment, and the social consequences) at baseline, 1 and 3 years after treatment initiation...
August 7, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30093174/sweet-taste-potentiates-the-reinforcing-effects-of-e-cigarettes
#16
Nils B Kroemer, Maria G Veldhuizen, Roberta Delvy, Barkha P Patel, Stephanie S O'Malley, Dana M Small
Electronic cigarettes (e-cigarettes) are becoming increasingly popular. The popularity of fruit flavors among e-cigarette users suggests that sweet taste may contribute to e-cigarette appeal. We therefore tested whether sweet taste potentiates the reinforcing effects of nicotine. Using a conditioning paradigm adapted to study e-cigarettes, we tested whether exposure to flavored e-cigarettes containing nicotine plus sweet taste would be more reinforcing than unsweetened e-cigarettes. Sixteen light cigarette smokers smoked 4 distinctly colored e-cigarettes containing sweetened and unsweetened flavors with or without nicotine for 2 days each...
August 6, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30087074/network-based-drug-repositioning-a-novel-strategy-for-discovering-potential-antidepressants-and-their-mode-of-action
#17
Ting-Ting Zhang, Rui Xue, Xin Wang, Shi-Wen Zhao, Lei An, Yun-Feng Li, You-Zhi Zhang, Shao Li
Current target-oriented paradigm for novel antidepressant discovery has been difficult to succeed and the failures always bring huge economic losses. Although abundant ledge of disease related genes and drug action targets has been accumulated, the successful application of the knowledge for new drug discovery is limited. Here, we predicted and validated potential antidepressants and molecular targets from DrugBank recorded drugs using a novel network-based drug repositioning approach. This approach predicted relationships between drug and targets through network-based integration of drug chemical similarity, therapeutic similarity and protein-protein interactions...
August 4, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30082141/serotonin-transporter-occupancy-by-the-ssri-citalopram-predicts-default-mode-network-connectivity
#18
Anouk Schrantee, Paul J Lucassen, Jan Booij, Liesbeth Reneman
The default mode network (DMN) is an important connectivity hub, and alterations may play a role in the pathophysiology of several neuropsychiatric disorders. Despite the growing body of research on DMN (dys)function, the underlying neurochemical substrate remains to be elucidated. The serotonergic neurotransmitter system has been suggested to play a substantial role in modulating the DMN. Therefore, we investigated the association between serotonin transporter (SERT) occupancy by the selective serotonin reuptake inhibitor citalopram and DMN functional connectivity...
August 3, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30082140/the-effects-of-synthetic-cannabinoids-scs-on-brain-structure-and-function
#19
A Livny, K Cohen, N Tik, G Tsarfaty, P Rosca, A Weinstein
There is an increasing use of "Novel Psychoactive Substances" containing synthetic cannabinoids worldwide. Synthetic cannabinoids (SC) are highly addictive and cause severe adverse effects. The purpose of our study was to assess whether chronic use of SC alters brain volume and function. Fifteen SC chronic users and 15 healthy control participants undertook an MRI scan to assess brain volume and function while performing a working memory N-back task and a response-inhibition Go-No-Go task. SC users showed impaired performance on the N-back task but not on the Go-No-Go task...
August 3, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30077433/seasonality-resilient-individuals-downregulate-their-cerebral-5-ht-transporter-binding-in-winter-a-longitudinal-combined-11-c-dasb-and-11-c-sb207145-pet-study
#20
Brenda Mc Mahon, Martin Nørgaard, Claus Svarer, Sofie B Andersen, Martin K Madsen, William F C Baaré, Jacob Madsen, Vibe G Frokjaer, Gitte M Knudsen
We have recently shown that the emergence and severity of seasonal affective disorder (SAD) symptoms in the winter is associated with an increase in cerebral serotonin (5-HT) transporter (SERT) binding. Intriguingly, we also found that individuals resilient to SAD downregulate their cerebral SERT binding in the winter. In the present paper, we provide an analysis of the SERT- and 5-HT dynamics as indexed by 5-HT4 receptor (5-HT4R) binding related to successful stress coping. We included 46 11 C-DASB positron emission tomography (PET) scans (N = 23, 13 women, age: 26 ± 6 years) and 14 11 C-SB207145 PET scans (7 participants, 3 women, age: 25 ± 3 years) from 23 SAD-resilient Danes...
August 1, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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