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Ultrasound in Obstetrics & Gynecology

Ingrid Volløyhaug, Annika Taithongchai, Isabelle van Gruting, Abdul Sultan, Ranee Thakar
OBJECTIVES: To estimate the prevalence and explore risk factors of levator ani muscle injury in women with clinically diagnosed obstetric anal sphincter injuries (OASIs). Secondly, we aimed to assess the association between levator injury and pelvic floor muscle contraction, anal incontinence (AI) and urinary incontinence (UI) in women with OASIs. METHODS: Cross-sectional study of 250 women with OASIs, recruited from 2013 until 2015 in a tertiary referral centre at Croydon University Hospital, UK...
September 11, 2018: Ultrasound in Obstetrics & Gynecology
Álvaro Sepúlveda-Martínez, Mérida Rodríguez-López, Fernanda Paz-Y-Miño, Giulia Casu, Francesca Crovetto, Eduard Gratacós, Fàtima Crispi
OBJECTIVE: To evaluate the transgenerational transmission of small for gestational age. METHODS: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation...
September 11, 2018: Ultrasound in Obstetrics & Gynecology
Rosemary Townsend, Francesco D'Antonio, Filomena Giulia Sileo, Hafsah Kumbay, Basky Thilaganathan, Asma Khalil
OBJECTIVES: To explore the impact of severity and management (expectant, laser treatment or selective reduction) on perinatal outcome of monochorionic twin pregnancies complicated by selective intra-uterine growth restriction (sFGR). METHODS: Medline, EMBASE, and the Cochrane database were searched. Only pregnancies affected by sFGR and categorized according to the Gratacos classification (Type I, II and III) were included. The primary outcome was mortality, including single and double intrauterine (IUD), neonatal (NND) and perinatal death (PND)...
September 11, 2018: Ultrasound in Obstetrics & Gynecology
M Tavares de Sousa, A Fonseca, K Hecher
No abstract text is available yet for this article.
September 11, 2018: Ultrasound in Obstetrics & Gynecology
Daniela Di Martino, Enrico Ferrazzi, Massimo Garbin, Federica Fusè, Teresa Izzo, Johannes Duvekot, Antonio Farina
BACKGROUND: The aim of this study was to evaluate the effect of intrauterine growth restriction on maternal hemodynamic parameters using a multivariable analysis, adjusting for major confounding factors, such as hypertensive disorders of pregnancy (preeclampsia and gestational hypertension). METHODS: A prospective cohort study was conducted between January 2013 and April 2016. Two cohorts of patients were recruited, between 24 and 39 weeks of gestation in high risk outpatient setting...
September 11, 2018: Ultrasound in Obstetrics & Gynecology
D Paladini, G Donarini, S Parodi, G Volpe, G Sglavo, E Fulcheri
OBJECTIVE: To assess the differential diagnostic significance of a series of quantitative and qualitative variables of the cerebellar vermis in 67 cases of posterior fossa cystic malformations including Dandy-Walker Malformation (DWM), Vermian Hypoplasia (VH), and Blake's Pouch Cyst (BPC), with particular attention at the differential diagnosis of the last two entities. METHODS: This is a retrospective study including all cases of DWM, VH and BPC diagnosed in the period 2005-2017, with good quality three-dimensional volume datasets of the posterior fossa acquired transvaginally, through the posterior fontanelle...
September 11, 2018: Ultrasound in Obstetrics & Gynecology
J Panaiotova, M Tokunaka, K Krajewska, N Zosmer, K H Nicolaides
OBJECTIVE: To estimate the diagnostic accuracy of a two-stage strategy for early prediction of morbidly adherent placenta (MAP). In the first stage, at 11-13 weeks' gestation, women with low-lying placenta and history of uterine surgery are classified as being at high risk for MAP and, in the second stage, at 12-16 weeks, these high-risk pregnancies are assessed at a specialist MAP clinic. METHODS: This was a prospective study in women having an ultrasound scan at 11-13 weeks' gestation as a part of routine pregnancy care...
September 10, 2018: Ultrasound in Obstetrics & Gynecology
Laïla Allach El Khattabi, Stéphanie Brun, Paul Gueguen, Nicolas Chatron, Erwan Guichoux, Sacha Schutz, Juliette Nectoux, Arthur Sorlin, Manal Quere, John Boudjarane, Vassilis Tsatsaris, Laurent Mandelbrot, Caroline Schluth-Bolard, Jean Michel Dupont, Caroline Rooryck
OBJECTIVES: To validate and evaluate an integrated protocol for non-invasive prenatal genetic screening (NIPS) for common fetal aneuploidies in a clinical setting, using the semiconductor sequencing technology, Ion Proton. METHODS: This prospective cohort study included 2505 pregnant women from seven academic genetic laboratories (695 high risk pregnancies in a validation study and 1810 pregnancies with a risk higher than 1/250 without ultrasound anomalies, in a real NIPS clinical setting)...
September 6, 2018: Ultrasound in Obstetrics & Gynecology
Emilie Thorup, Lisa N Jensen, Geske S Bak, Charlotte K Ekelund, Gorm Greisen, Ditte S Jørgensen, Signe G Hellmuth, Camilla Wulff, Olav B Petersen, Lars H Pedersen, Ann Tabor
OBJECTIVES: The aim of this study was to estimate the prevalence of specific neurodevelopmental disorders in children prenatally believed to have isolated mild ventriculomegaly in the second trimester of pregnancy to optimize the counselling process. METHODS: This was a nationwide register based study including all singleton pregnancies which had a first and second trimester scan in the period 1 January 2008 to 1 October 2014, identified through the Danish Fetal Medicine Database and from local clinical databases...
August 31, 2018: Ultrasound in Obstetrics & Gynecology
Greggory R DeVore, Bettina F Cuneo, Gary Satou, Mark Sklansky
If a diagnostic test has a significant P-value when comparing a control group with a study group (e.g. myocardial performance index, tricuspid annular plane systolic excursion, global sphericity index, etc.) then clinicians interested in the results may desire to know the percentage of the studied population that had abnormal values (i.e. <5th or > 95th centiles) when these data are not provided in the published study. 1-4 This article is protected by copyright. All rights reserved.
August 29, 2018: Ultrasound in Obstetrics & Gynecology
Hagit Daum, Arbel Ben David, Michel Nadjari, Shamir Zenvirt, Sarit Helman, Nili Yanai, Vardiella Meiner, Simcha Yagel, Ayala Frumkin, Shiri Shkedi Rafid
INTRODUCTION: The traditional timing for amniocentesis is between 17-23 weeks of pregnancy. This timing enables pregnancy associated decisions to be made before viability. Less frequently, third trimester amniocentesis is performed. Advanced genomic technologies such as chromosomal microarray analysis (CMA) introduce far more detailed information about the fetus compared to traditional G-banded chromosomal analysis. Not much is known about the indications, safety and CMA yield for late amniocentesis...
August 28, 2018: Ultrasound in Obstetrics & Gynecology
Asma Khalil
On June 15th this year, MBRRACE published its report1 focusing on perinatal deaths in the UK in 2016. While disappointing that the rate of stillbirths in singletons remained static, the report described a significant fall in the rate of stillbirths and neonatal deaths in twin pregnancies. In fact, the stillbirth rate was almost halved from 11.07 (95% CI, 9.78 to 12.47) per 1,000 births in 2014 to 6.16 (95% CI, 5.20 to 7.24) in 2016 (Table 1, Figure 1). The neonatal mortality rate in twins also fell significantly from 7...
August 27, 2018: Ultrasound in Obstetrics & Gynecology
Boris Tutschek
In the 1880s, based on histological examinations of embryos and fetuses, Wilhelm His established classic human embryology. He emphasized the need for 3D models 1 . In 1883, Gustav Born wrote: 'As also His repeatedly points out, it is essential for developmental studies, to "raise beyond the mere viewing of sections to a plastic synthesis of the studied tissues" and to "put together the numerous sections… into a simple representation of physical nature"'. This article is protected by copyright...
August 27, 2018: Ultrasound in Obstetrics & Gynecology
W Lau, W Yung, W Leung, A Kan, K Chan, H Luk, E Kan, Y Lam
This is the first pregnancy of a 22 years old healthy women from non-consanguineous marriage. A small 6 to 7mm occipital cystic mass was noted on anomaly scan at 17wk (figure 1). Amniocentesis was performed at 20 weeks gestation for conventional cytogenetics revealed normal karyotype 46,XX. Array comparative genomic hybridization (aCGH) showed arr[GRCh37] 5q35.2(173909361_175173029)x1 of maternal inheritance. This article is protected by copyright. All rights reserved.
August 27, 2018: Ultrasound in Obstetrics & Gynecology
Kohei Seo, Kiyotake Ichizuka, Takashi Okai, Satoshi Dohi, Masamitsu Nakamura, Junichi Hasegawa, Ryu Matsuoka, Shin Yoshizawa, Shin-Ichiro Umemura, Masaaki Nagatsuka, Akihiko Sekizawa
The aim of this study was to clinically evaluate the efficacy of high-intensity focused ultrasound (HIFU) for fetal therapy of twin-reversed arterial perfusion (TRAP) sequence. Six patients underwent HIFU therapy: five patients during the first trimester and one patient during the second trimester. In this study, two types of HIFU systems were used. The first-generation HIFU system comprised a biaxial transducer and continuous exposure pattern. The second-generation HIFU system comprised a coaxial transducer and sequential exposure pattern...
August 22, 2018: Ultrasound in Obstetrics & Gynecology
N Chatron, M Till, C Abel, C Bardel, F Ramond, D Sanlaville, C Schluth-Bolard
Non Invasive Prenatal Testing (NIPT) methods relying on low-pass whole genome sequencing can be used for pangenomic testing as karyotyping. Within the H+ Consortium, we developed an in-house NIPT using whole genome semi-conductor sequencing. A minimum of 8 million aligned deduplicated reads were necessary for WISECONDOR analysis (1) based on a local reference dataset of 31 euploid samples. Patients were informed of potential secondary findings during pre-test counseling. Karyotype techniques were performed using standard procedures either on amniotic fluid (AF) cell culture during pregnancy or on placental tissue obtained after delivery...
August 20, 2018: Ultrasound in Obstetrics & Gynecology
D Oros, S Ruiz-Martinez, E Staines-Urias, A Conde-Agudelo, J Villar, E Fabre, A T Papageorghiou
OBJECTIVES: To assess studies reporting reference ranges for Doppler indices of umbilical artery (UA), middle cerebral artery (MCA) and cerebroplacental ratio (CPR), using a set of predefined methodological quality criteria for study design, statistical analysis and reporting methods. METHODS: A systematic review of observational studies whose primary aim was to create reference ranges for Doppler indices of UA, MCA, and CPR in fetuses from singleton gestations was performed in MEDLINE, EMBASE, CINAHL, and Web of Science (all from inception to December 31, 2016), and references of retrieved articles...
August 20, 2018: Ultrasound in Obstetrics & Gynecology
Asma Khalil, Basky Thilaganathan
Despite advances in antenatal care, fetal growth restriction (FGR) continues to contribute to excess perinatal mortality and morbidity. The literature has recently been enriched with several landmark studies on FGR, which will facilitate standardization of the diagnostic criteria, identification of the at-risk fetus, prenatal screening, candidate preventors and optimal management. However, these studies have focused on singleton pregnancies and largely excluded twin gestations. Recently, an international consensus definition of FGR, as well as a consenus on the essential variables for reporting research studies on FGR, in singleton pregnancies has been published1,2 ...
August 20, 2018: Ultrasound in Obstetrics & Gynecology
Francesco D'Antonio, Anthony Odibo, Vincenzo Berghella, Asma Khalil, Karien Hack, Gabriele Saccone, Federico Prefumo, Danilo Buca, Marco Liberati, Giorgio Pagani, Ganesh Acharya
OBJECTIVE: To quantify the rate of perinatal mortality in monochorionic monoamniotic (MCMA) twin pregnancies according to gestational age and to ascertain the incidence of mortality in pregnancies managed as inpatient compared to outpatient. METHODS: Medline, Embase and Cinahl databases were searched. The primary outcomes explored were the incidence of intrauterine death (IUD), neonatal death (NND) and perinatal (PND) death in MCMA twin pregnancies at different gestational age windows (24-30, 31-32, 33-34, 35-36 and beyond 37 weeks of gestation)...
August 20, 2018: Ultrasound in Obstetrics & Gynecology
Cosimo Marco Campanale, Luciano Pasquini, Teresa Pia Santangelo, Fiore Salvatore Iorio, Pietro Bagolan, Stephen P Sanders, Alessandra Toscano
OBJECTIVES: To report our experience with fetal diagnosis of right aortic arch (RAA) variants based on the ductus arteriosus (DA) anatomy and brachiocephalic vessel branching pattern (BVBP) respectively to the trachea and to establish whether the echocardiographic "V-shaped" or "U-shaped" appearances of the fetal upper mediastinum were sufficiently accurate for fetal aortic arch (AA) assessment. METHODS: We retrospectively identified patients with a fetal diagnosis of RAA referred to our tertiary center from 2011 to 2017 and selected those who had post-natal confirmation of AA anatomy...
August 20, 2018: Ultrasound in Obstetrics & Gynecology
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