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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/28089339/discovery-of-a-murine-model-of-clinical-pah-mission-impossible
#1
REVIEW
Zhiyu Dai, You-Yang Zhao
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH...
December 15, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28089202/cryoballoon-ablation-versus-radiofrequency-ablation-for-atrial-fibrillation
#2
REVIEW
Bruno Reissmann, Andreas Metzner, Karl-Heinz Kuck
No abstract text is available yet for this article.
December 14, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28040325/why-are-south-asians-seemingly-protected-against-the-development-of-atrial-fibrillation-a-review-of-current-evidence
#3
REVIEW
James O'Neill, Muzahir H Tayebjee
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is strongly associated with conditions such as valvular heart disease, coronary artery disease and particularly hypertension and diabetes mellitus. The South Asian ethnic group have high rates of these conditions and so would be expected to be at significant risk of AF. However, observational studies have consistently shown that South Asians have a lower prevalence of AF compared with Caucasians. This article summarizes current evidence surrounding the development of AF and its relationship to ethnicity, offers potential reasons for this disparity and identifies future areas of research...
November 25, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28040327/the-role-of-electronegative-low-density-lipoprotein-in-cardiovascular-diseases-and-its-therapeutic-implications
#4
REVIEW
Sumeyya Akyol, Jonathan Lu, Omer Akyol, Fatih Akcay, Ferah Armutcu, Liang-Yin Ke, Chu-Huang Chen
Cardiovascular disease (CVD) is a health problem of great concern to both the public and medical authorities. Low-density lipoprotein (LDL) has been reported to play an important role in both the development and progression of CVD, but studies are underway to determine how LDL exerts its effects. In recent years, it has been found that LDL has several subfractions, each of which affects endothelial function differently; L5, the most electronegative fraction, has been shown to be unique in that it induces an atherogenic response...
November 19, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28040326/clinical-gene-therapy-trials-for-heart-failure-did-they-fail
#5
EDITORIAL
Shin Watanabe, Kiyotake Ishikawa
No abstract text is available yet for this article.
November 16, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28063800/gene-therapy-for-heart-failure
#6
REVIEW
Barry Greenberg
Novel strategies are needed to treat the growing population of heart failure patients. While new drug and device based therapies have improved outcomes over the past several decades, heart failure patients continue to experience amongst the lowest quality of life of any chronic disease, high likelihood of being hospitalized and marked reduction in survival. Better understanding of many of the basic mechanisms involved in the development of heart failure has helped identify abnormalities that could potentially be targeted by gene transfer...
November 5, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27989286/my-approach-to-the-surgeon-s-view-on-degenerative-mitral-regurgitation
#7
Christina M Vassileva
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27989285/my-approach-to-the-evaluation-of-restrictive-cardiomyopathy
#8
Craig R Asher, Allan L Klein
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27612552/editorial-commentary-the-holy-grail-of-atrial-fibrillation
#9
EDITORIAL
Faisal F Syed, Hakan Oral
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27591800/editorial-commentary-beyond-the-guidelines-to-expertise-in-precision-stroke-medicine
#10
EDITORIAL
David S Liebeskind
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27544725/editorial-commentary-chronic-thromboembolic-pulmonary-hypertension-evolves-diagnostically-and-therapeutically
#11
EDITORIAL
Friedrich C Luft
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27520496/update-on-atrial-fibrillation
#12
REVIEW
Amanulla Khaji, Peter R Kowey
Atrial fibrillation (AF) is the most common arrhythmia with a substantial effect on individual morbidity and mortality as well as healthcare expenditure. The management of AF is complex and fraught with many uncertain and contentious issues. We have seen substantial progress in AF management in the last two decades including better understanding of the epidemiology, genomics, monitoring, drug and non-pharmacological treatment of the arrhythmia, its complications and stroke risk reduction. In this review, we present a comprehensive discussion on AF with emphasis on most recent updates...
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27499040/reply-evolutionary-approach-sheds-light-on-the-significance-of-vascular-calcification
#13
LETTER
Linda L Demer, Yin Tintut
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27495359/reply-evolution-and-vascular-calcification
#14
LETTER
Carlos de C├ęspedes
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27492815/atrial-fibrillation-driver-mechanisms-insight-from-the-isolated-human-heart
#15
REVIEW
Thomas A Csepe, Brian J Hansen, Vadim V Fedorov
Although there have been great technological advances in the treatment of atrial fibrillation (AF), current therapies remain limited due to a narrow understanding of AF mechanisms in the human heart. This review will highlight our recent studies on explanted human hearts where we developed and employed a novel functional-structural mapping approach by integrating high-resolution simultaneous endo-epicardial and panoramic optical mapping with 3D gadolinium-enhanced MRI to define the spatiotemporal characteristics of AF drivers and their structural substrates...
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27471112/acute-stroke-therapy-a-review
#16
REVIEW
Tomas Peisker, Boris Koznar, Ivana Stetkarova, Petr Widimsky
This review summarizes the modern early diagnosis and acute phase treatment of acute stroke. The guidelines for treatment of acute ischemic stroke underwent major changes in 2015 and endovascular therapy (catheter-based mechanical thrombectomy with a stent retriever) became the class IA indication for patients presenting within less than 6h from symptom onset who have proven occlusion of large intracerebral artery in anterior circulation. Acute stroke care organization should enable to perform effective revascularization therapy as soon as possible after the initial brain imaging whenever this examination provides indication for the procedure...
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27452966/diagnosis-and-management-of-adult-hereditary-cardio-neuromuscular-disorders-a-model-for-the-multidisciplinary-care-of-complex-genetic-disorders
#17
REVIEW
R Brian Sommerville, Margherita Guzzi Vincenti, Kathleen Winborn, Anne Casey, Nathan O Stitziel, Anne M Connolly, Douglas L Mann
Genetic disorders that disrupt the structure and function of the cardiovascular system and the peripheral nervous system are common enough to be encountered in routine cardiovascular practice. Although often these patients are diagnosed in childhood and come to the cardiologist fully characterized, some patients with hereditary neuromuscular disease may not manifest until adulthood and will present initially to the adult cardiologist for an evaluation of an abnormal ECG, unexplained syncope, LV hypertrophy, and or a dilated cardiomyopathy of unknown cause...
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27425561/editorial-commentary-high-sensitivity-cardiac-troponin-like-every-new-tool-there-is-a-learning-curve
#18
EDITORIAL
Peter A Kavsak
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27425560/editorial-commentary-mapping-of-persistent-atrial-fibrillation-can-the-driver-mechanisms-be-determined-in-the-clinical-setting
#19
EDITORIAL
Thomas H Everett
No abstract text is available yet for this article.
January 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27422097/cardiac-troponin-as-a-novel-tool-for-cardiovascular-risk-prediction-in-ambulatory-populations
#20
REVIEW
Brendan M Everett
Assays for cardiac troponin have become increasingly sensitive, and are now able to detect very low concentrations of circulating cardiac troponin in a substantial proportion of stable patients who are not suspected of having an acute myocardial infarction. These low concentrations of cardiac troponin are frequently well within the range of what is considered normal but are nonetheless associated with a significant increase in the risk of major cardiovascular events, including heart failure, myocardial infarction, and death in patients with and without established cardiovascular disease...
January 2017: Trends in Cardiovascular Medicine
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