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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/28438398/triglycerides-a-reappraisal
#1
REVIEW
Philipp Wiesner, Karol E Watson
Elevated cholesterol levels are clearly independently associated with adverse cardiovascular events. Another class of lipid particles, triglycerides, is also abundant in the human body and has been found in atherosclerotic plaques. Recent observational studies have demonstrated an association between elevated triglyceride levels and increased risk for future cardiovascular events. With this knowledge and the discovery of effective agents to lower triglyceride levels, the management of triglycerides is currently undergoing a renaissance...
March 21, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438397/endothelial-to-mesenchymal-transition-a-novel-therapeutic-target-for-cardiovascular-diseases
#2
REVIEW
Ampadu O Jackson, Jingjing Zhang, Zhisheng Jiang, Kai Yin
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of cardiovascular diseases (CVDs), and may represent a novel therapeutic target for cardiovascular remodeling and fibrotic disorders...
March 16, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438399/type-2-myocardial-infarction-due-to-supply-demand-mismatch
#3
REVIEW
Nino Mihatov, James L Januzzi, Hanna K Gaggin
The best-accepted definition of myocardial infarction (MI) is provided by statements from the Universal Definition of MI Global Task force. This article, now in its third iteration, defines MI as myocardial cell death due to prolonged myocardial ischemia. It further delineates an increasingly incident subclassification of MI known as type 2 MI (T2MI). T2MI identifies instances of myocardial necrosis in which an imbalance between myocardial oxygen supply and/or demand occurs for reasons other than atherosclerotic plaque disruption...
March 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28392173/editorial-commentary-cardiac-rehabilitation-major-benefits-and-minor-risks
#4
EDITORIAL
Jennifer G Foster, Steven F Lewis, Charles H Hennekens
No abstract text is available yet for this article.
March 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28351697/non-invasive-assessment-of-myocardial-fibrosis-focus-on-the-substrate-of-ventricular-arrhythmias-to-improve-risk-stratification
#5
EDITORIAL
Andrea Di Marco
No abstract text is available yet for this article.
February 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28351696/new-drugs-for-diabetes-finally-safety-and-cardiovascular-efficacy
#6
EDITORIAL
Kim A Connelly
No abstract text is available yet for this article.
February 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28318815/the-role-of-cardiac-rehabilitation-in-patients-with-heart-disease
#7
REVIEW
Sean R McMahon, Philip A Ades, Paul D Thompson
Cardiac rehabilitation is a valuable treatment for patients with a broad spectrum of cardiac disease. Current guidelines support its use in patients after acute coronary syndrome, coronary artery bypass grafting, coronary stent placement, valve surgery, and stable chronic systolic heart failure. Its use in these conditions is supported by a robust body of research demonstrating improved clinical outcomes. Despite this evidence, cardiac rehabilitation referral and attendance remains low and interventions to increase its use need to be developed...
February 15, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291653/lifestyle-and-life-long-lasting-cardiovascular-health
#8
EDITORIAL
Luis A Moreno
No abstract text is available yet for this article.
February 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28274655/high-sensitive-troponin-a-new-tool-for-clinical-decision-making-in-valvular-heart-disease
#9
EDITORIAL
Johanne Frank, Norbert Frey, Derk Frank
No abstract text is available yet for this article.
February 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291654/comments-on-letter-to-the-editor-entitled-role-of-electrophysiological-evaluation-for-the-best-device-choice-to-prevent-sudden-cardiac-death-in-patients-with-myotonic-dystrophy-type1-and-emery-dreifuss-muscular-dystrophy
#10
LETTER
R B Sommerville, M G Vincenti, K Winborn, A Casey, N O Stitziel, A M Connolly, D L Mann
No abstract text is available yet for this article.
February 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28237579/role-of-electrophysiological-evaluation-for-the-best-device-choice-to-prevent-sudden-cardiac-death-in-patients-with-myotonic-dystrophy-type-1-and-emery-dreifuss-muscular-dystrophy
#11
LETTER
Vincenzo Russo, Luisa Politano, Gerardo Nigro
No abstract text is available yet for this article.
February 5, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28262437/myocardial-fibrosis-predicts-ventricular-tachyarrhythmias
#12
REVIEW
Marcello Disertori, Michela Masè, Flavia Ravelli
Myocardial fibrosis is a common pattern in the setting of different heart diseases, and promotes ventricular tachyarrhythmias by creating a vulnerable substrate for reentrant activity and by favoring the emergence of triggers. Currently, late gadolinium enhancement (LGE) cardiac magnetic resonance is considered the reference method for the noninvasive assessment of ventricular fibrosis. Several studies and meta-analyses have shown that ventricular fibrosis detected by LGE is a powerful predictor of ventricular tachyarrhythmic events in ischemic, non-ischemic dilated cardiomyopathy and hypertrophic cardiomyopathy patients...
February 2, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28089339/discovery-of-a-murine-model-of-clinical-pah-mission-impossible
#13
REVIEW
Zhiyu Dai, You-Yang Zhao
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH...
May 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291655/the-cardiovascular-safety-trials-of-dpp-4-inhibitors-glp-1-agonists-and-sglt2-inhibitors
#14
REVIEW
Matthew H Secrest, Jacob A Udell, Kristian B Filion
In this paper, we review the results of large, double-blind, placebo-controlled randomized trials mandated by the US Food and Drug Administration to examine the cardiovascular safety of newly-approved antihyperglycemic agents in patients with type 2 diabetes. The cardiovascular effects of dipeptidyl peptidase-4 (DPP-4) inhibitors remain controversial: while these drugs did not reduce or increase the risk of primary, pre-specified composite cardiovascular outcomes, one DPP-4 inhibitor (saxagliptin) increased the risk of hospitalization for heart failure in the overall population; another (alogliptin) demonstrated inconsistent effects on heart failure hospitalization across subgroups of patients, and a third (sitagliptin) demonstrated no effect on heart failure...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27717538/non-invasive-assessment-of-low-and-intermediate-risk-patients-with-chest-pain
#15
REVIEW
Pelbreton C Balfour, Jorge A Gonzalez, Christopher M Kramer
Coronary artery disease (CAD) remains a significant global public health burden despite advancements in prevention and therapeutic strategies. Common non-invasive imaging modalities, anatomic and functional, are available for the assessment of patients with stable chest pain. Exercise electrocardiography is a long-standing method for evaluation for CAD and remains the initial test for the majority of patients who can exercise adequately with a baseline interpretable electrocardiogram. The addition of cardiac imaging to exercise testing provides incremental benefit for accurate diagnosis for CAD and is particularly useful in patients who are unable to exercise adequately and/or have uninterpretable electrocardiograms...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28107840/my-approach-to-managing-statin-associated-muscle-symptoms
#16
Paul D Thompson
No abstract text is available yet for this article.
February 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28107839/my-approach-to-the-patient-with-memory-loss-who-needs-a-statin
#17
Karol E Watson, Tamer Sallam
No abstract text is available yet for this article.
February 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27665047/editorial-commentary-anti-glycemic-drugs-and-heart-failure-a-new-era
#18
EDITORIAL
David Fitchett
No abstract text is available yet for this article.
February 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27612553/impact-of-empagliflozin-in-patients-with-diabetes-and-heart-failure
#19
REVIEW
David Pham, Natalia De Albuquerque Rocha, Darren K McGuire, Ian J Neeland
Heart failure (HF) is a common disease with increased risk for mortality and morbidity among patients with type 2 diabetes mellitus (T2DM). Optimal glycemic control in this patient population is challenging as many available therapies can potentially exacerbate symptoms of HF. Empagliflozin is one in a novel class of agents, the sodium glucose co-transporter 2 (SGLT2) inhibitors, that lowers blood glucose by increasing urinary glucose excretion and improves glycemic control and lowers body weight and blood pressure...
February 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27612551/cardiovascular-disease-in-patients-with-rheumatoid-arthritis
#20
REVIEW
Katherine P Liao
The risk of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) is 1.5-2-fold higher than age- and sex-matched individuals from the general population. This excess risk is attributed to the systemic chronic inflammation which is a hallmark of RA. Challenges to optimizing CV risk management in RA include the need for improved methods to predict CV risk, and defining the target risk factor(s) to reduce CV risk. Lessons learned from RA studies can also inform CV risk prevention in the general population, where inflammation also has an important role in the pathogenesis of atherosclerosis...
February 2017: Trends in Cardiovascular Medicine
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