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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/29983337/cardiovascular-magnetic-resonance-imaging-for-amyloidosis-the-state-of-the-art
#1
REVIEW
Chun Xiang Tang, Steffen E Petersen, Mihir M Sanghvi, Guang Ming Lu, Long Jiang Zhang
Amyloidosis results from insoluble precursor proteins being deposited in the extracellular compartment. The prognosis of the disease is predominantly determined by cardiac involvement due to amyloid accumulation that contributes to cardiac dysfunction and disturbed conduction of cardiac electrical signals. The clinical and radiological manifestations of amyloidosis are often non-specific, making amyloidosis a diagnostic challenge both for clinicians and radiologists. Cardiovascular magnetic resonance imaging, including conventional sequences, late gadolinium enhancement, T1 mapping and determination of extracellular volume fraction is a multi-dimensional modality for the assessment and diagnosis of cardiac amyloidosis and, in addition, is an excellent tool for risk stratification and disease tracking...
June 28, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29970286/non-invasive-imaging-techniques-and-assessment-of-carotid-vasa-vasorum-neovascularization-promises-and-pitfalls
#2
REVIEW
T Pereira, A Betriu, R Alves
Carotid adventitia vasa vasorum neovascularization (VVn) is associated with the initial stages of arteriosclerosis and with the formation of unstable plaque. However, techniques to accurately quantify that neovascularization in a standard, fast, non-invasive, and efficient way are still lacking. The development of such techniques holds the promise of enabling wide, inexpensive, and safe screening programs that could stratify patients and help in personalized preventive cardiovascular medicine. In this paper, we review the recent scientific literature pertaining to imaging techniques that could set the stage for the development of standard methods for quantitative assessment of atherosclerotic plaque and carotid VVn...
June 21, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29970287/to-pace-or-not-to-pace-in-vasovagal-syncope
#3
EDITORIAL
Hiroshi Morita
No abstract text is available yet for this article.
June 19, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29958808/editorial-commentary-update-on-cardio-oncology-novel-cancer-therapeutics-and-associated-cardiotoxicities
#4
EDITORIAL
Juan Lopez-Mattei, Peter Kim, Cezar Iliescu
No abstract text is available yet for this article.
June 19, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29937218/gout-and-arrhythmias-in-search-for-causation-beyond-association
#5
REVIEW
Georgios Giannopoulos, Christos Angelidis, Spyridon Deftereos
Gout is a systemic disease, characterized by the formation and deposition of crystals in tissues (mainly in and around the joints) of individuals with elevated serum uric acid levels. Lately, a considerable number of reports relating elevated uric acid and/or gout with rhythm disorders, such as atrial fibrillation, have been published. This review summarizes evidence linking common arrhythmias and hyperuricemia/gout and discusses questions or controversies that surround it. Overall, existing evidence may not be overwhelming, but strongly suggests a positive correlation between uric acid levels and common rhythm disorders...
June 13, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29941243/female-sex-as-a-biological-variable-a-review-on-younger-patients-with-acute-coronary-syndrome
#6
REVIEW
Raffaele Bugiardini, Olivia Manfrini, Edina Cenko
Although acute coronary syndrome (ACS) mainly occurs in individuals >60 years, younger adults can be affected as well. Women continue to be at higher risk of 30-day mortality after ST-segment elevation myocardial infarction (STEMI) even in the current era of percutaneous coronary intervention (PCI). Importantly, the excess mortality among women is only significant at younger ages. Previous work has suggested that the reason for the differences in outcome is likely multifactorial and may partially be explained by some of the following factors: atypical presentation, delayed presentation, under-recognition of STEMI at initial medical contact, and underuse of medications because of concern regarding increased risk of bleeding...
June 12, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29907466/sudden-death-risk-markers-for-patients-with-left-ventricular-ejection-fractions-greater-than-40
#7
REVIEW
Brian P Halliday, Amrit S Lota, Sanjay K Prasad
The major burden of sudden cardiac death (SCD) in patients with heart disease occurs in those with a left ventricular ejection fraction > 40%. Although the annual risk of SCD may be lower in these patients compared to those with lower LVEF, their lifetime cumulative risk of SCD may be greater due to a better overall prognosis. It is plausible that those with LVEF > 40% who are at highest risk of life-threatening arrhythmia will benefit from implantable cardioverter defibrillators. Features that identify patients with a LVEF > 40% at high risk of SCD are urgently needed...
June 12, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29910109/update-on-cardio-oncology-novel-cancer-therapeutics-and-associated-cardiotoxicities
#8
REVIEW
Avirup Guha, Merna Armanious, Michael G Fradley
There have been significant advances in the field of oncology leading to improved survival as a result of novel targeted and immunotherapies. Despite these improved outcomes, there is increased recognition of cardiotoxicities associated with these therapies that can lead to significant morbidity and mortality. As such, the field of cardio-oncology has seen significant growth over the last several years. In this review, we discuss recent advances in the field of cardio-oncology and provide a detailed discussion of the cardiovascular complications associated with novel cancer therapeutics including tyrosine kinase inhibitors, proteasome inhibitors, histone deacetylase inhibitors, CDK4/6 inhibitors and immunotherapies...
June 8, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29908827/naming-the-misfits-minoca-acsnnoca-and-the-rest-of-the-family
#9
EDITORIAL
Radmila Lyubarova, Joshua Schulman-Marcus
No abstract text is available yet for this article.
June 5, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29934015/oxidized-ldl-and-anti-oxidized-ldl-antibodies-in-atherosclerosis-novel-insights-and-future-directions-in-diagnosis-and-therapy
#10
REVIEW
Adam Hartley, Dorian Haskard, Ramzi Khamis
We provide an up-to-date overview of current topics surrounding oxidized low-density lipoprotein (oxLDL) and its related antibodies in the quest to better identify the individuals at risk of cardiovascular disease and atherosclerotic plaques with unfavorable characteristics. We discuss the potential of oxLDL and anti-oxLDL antibodies as serum biomarkers of cardiovascular disease and emerging studies examining the targeting of arterial oxLDL for imaging and therapeutic delivery.
June 4, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29891330/perspectives-on-the-relation-of-blood-pressure-and-cognition-in-the-elderly
#11
REVIEW
Christopher Goshgarian, Philip B Gorelick
The relationship of blood pressure to cognition in the elderly is a poorly understood topic. Many questions exist such as does treatment of hypertension prevent cognitive decline, the optimal timing of intervention and selecting the appropriate agent. In this review we will explore recent epidemiologic data and clinical trials addressing hypertension and cognition, review pathophysiology of chronic hypertension and effects of brain function, discuss the timing of intervention and finally review opportunities for future research...
June 2, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29887222/two-faces-of-janus-the-complexities-of-coronary-artery-calcium-density-and-distribution
#12
EDITORIAL
Maros Ferencik, James E Udelson
No abstract text is available yet for this article.
May 29, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29884569/sudden-cardiac-death-prediction-in-the-general-population-and-among-patients-with-left-ventricular-ejection-fractions-greater-than-40
#13
EDITORIAL
Thomas Hadberg Lynge, Bo Gregers Winkel, Jacob Tfelt-Hansen
No abstract text is available yet for this article.
May 29, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29880235/a-systematic-view-on-e3-ligase-ring-trimmers-with-a-focus-on-cardiac-function-and-disease
#14
REVIEW
Ankush Borlepawar, Norbert Frey, Ashraf Yusuf Rangrez
Ubiquitination, a post-translational modification via ubiquitin-proteasome-system, is one of the vital cellular processes involved in intracellular signaling, cell death, transcriptional control, etc. Importantly, it prevents the aggregation of non-functional, misfolded or unfolded, potentially toxic proteins to maintain cellular protein homeostasis. Ubiquitination is accomplished by the concerted action of three enzymatic steps involving E1 activating enzymes, E2 conjugating enzymes, and E3 ligases. Tripartite motif-containing (TRIM) proteins are one of the integral members of E3 ubiquitin ligases in metazoans modulating essential cellular pathways...
May 28, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29859655/acute-coronary-syndromes-in-patients-with-angiographically-normal-or-near-normal-non-obstructive-coronary-arteries
#15
REVIEW
Antonis S Manolis, Antonis A Manolis, Theodora A Manolis, Helen Melita
Patients with acute coronary syndrome (ACS) with normal or near-normal (non-obstructive) coronary arteries (ACSNNOCA) constitute an important, albeit heterogeneous, patient subset of younger patients, more commonly females, who may have lower risk of cardiovascular events compared to patients with obstructive coronary artery disease; however this risk remains substantial, hence needing further investigation to identify the underlying cause and devise a proper therapeutic strategy. A diagnostic algorithm starts during coronary angiography with some essential additional diagnostic steps, such as a left ventricular angiogram that may readily identify the underlying cause, e...
May 23, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29853424/pushing-preeclampsia-back-to-pre-preeclampsia
#16
EDITORIAL
Friedrich C Luft, Ralf Dechend
No abstract text is available yet for this article.
May 21, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29880234/technology-to-treat-heart-failure-friend-or-foe
#17
EDITORIAL
Sitaramesh Emani
No abstract text is available yet for this article.
May 19, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29843961/vasovagal-syncope-role-of-closed-loop-stimulation-pacing
#18
REVIEW
Mohammed Ruzieh, Blair P Grubb
The benefit of conventional pacing in vasovagal syncope remains controversial and is currently recommended for patients with recurrent syncope and documented asystole. In the last two decades, a growing body of evidence has emerged supporting the use of a new sensing technique called closed loop stimulation or CLS, to treat refractory vasovagal syncope. CLS uses a sensing algorithm that can detect variation in cardiac contractility and respond to drop in blood pressure by increasing the heart rate. Multiple observational and randomized studies have assessed its efficacy and showed its superiority to conventional pacing in reducing the burden of syncopal attacks in patients with cardio-inhibitory vasovagal syncope...
May 17, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29807666/reversal-of-coronary-atherosclerosis-role-of-life-style-and-medical-management
#19
REVIEW
Christine Parsons, Pradyumna Agasthi, Farouk Mookadam, Reza Arsanjani
Atherosclerotic coronary artery disease continues to be a major global health burden in developing and developed nations. Newer imaging techniques afford an accurate assessment of plaque burden and characteristics as well as the effects of treatment. Lifestyle interventions and pharmacotherapy remain the mainstay of non-interventional treatment of coronary atherosclerosis, with reversal seen in many studies. In addition, control of modifiable risk factors can be beneficial. As a better understanding of atherosclerosis pathophysiology is achieved, new therapeutic targets and combination therapies may join the armamentarium that promotes regression of atherosclerotic plaque...
May 17, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29884568/preeclampsia-and-the-cardiovascular-system-an-update
#20
REVIEW
Helen Perry, Asma Khalil, Basky Thilaganathan
No abstract text is available yet for this article.
May 15, 2018: Trends in Cardiovascular Medicine
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