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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/28601251/reprint-of-editiorial-commentary-genomics-and-drug-discovery-the-next-frontier-in-precision-medicine
#1
EDITORIAL
Dan M Roden
No abstract text is available yet for this article.
June 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28629865/editorial-commentary-coronary-artery-calcification-on-non-cardiac-chest-ct-incidental-but-impactful
#2
EDITORIAL
Aalap Chokshi, James E Udelson
No abstract text is available yet for this article.
May 16, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28623083/editorial-commentary-atrial-fibrillation-challenges-and-opportunities
#3
EDITORIAL
Heikki V Huikuri
No abstract text is available yet for this article.
May 15, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28625728/treatment-of-persistent-ventricular-tachycardia-drugs-or-ablation
#4
REVIEW
Ciorsti J MacIntyre, John L Sapp
Implantable cardioverter defibrillators (ICDs) reduce the mortality risk associated with recurrent ventricular tachycardia (VT) and can frequently terminate VT episodes painlessly, but do not prevent recurrent episodes. For patients with symptomatic recurrences, frequent asymptomatic recurrences, ICD shocks, or VT storm, most clinicians recommend strategies to suppress VT. The proarrhythmic mortality risk of antiarrhythmic drugs (AADs) may be mitigated by the presence of an ICD, but these medications are limited by high recurrence rates, and unfavorable side effect profiles...
May 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28619579/recording-sympathetic-nerve-activity-from-the-skin
#5
REVIEW
Thomas H Everett, Anisiia Doytchinova, Yong-Mei Cha, Peng-Sheng Chen
Sympathetic tone is important in cardiac arrhythmogenesis; however, methods to estimate sympathetic tone are either invasive or require proper sinus node function that may be abnormal in disease states. Because of the direct and extensive connections among various nerve structures, it is possible for the sympathetic nerves in the various structures to activate simultaneously. Therefore, we hypothesized that nerve activity can be recorded from the skin and it can be used to estimate the cardiac sympathetic tone...
May 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28602539/causes-of-death-in-atrial-fibrillation-challenges-and-opportunities
#6
REVIEW
Antonio Gómez-Outes, Maria Luisa Suárez-Gea, Jose Manuel García-Pinilla
Atrial fibrillation (AF) is an age-related arrhythmia associated with several co-morbidities and significant mortality. Most AF patients are in need of anticoagulation due to increased risk of stroke. Despite anticoagulation, AF patients still have a significant risk of death (about 5%/y). Approximately half of deaths in AF are due to heart-related causes (i.e., sudden death, heart failure, and myocardial infarction), one-third of deaths are due to non-vascular causes (i.e., cancer, respiratory diseases, and infections) and the remaining AF patients die from stroke or hemorrhage (about 6% each), or other causes...
May 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28600103/time-honored-treatments-for-the-initial-management-of-acute-coronary-syndromes-challenging-the-status-quo
#7
REVIEW
Cian P McCarthy, Eoin Donnellan, Jason H Wasfy, Deepak L Bhatt, John W McEvoy
Morphine, oxygen, and nitrates are time-honored therapies for the initial management of acute coronary syndrome (ACS). The traditional goal of these agents in ACS has been to (1) relieve symptoms, (2) prevent infarction or limit its size, and (3) improve outcomes, both acutely and during follow-up. Despite their ongoing use in routine ACS care, nitrates, morphine, and oxygen have no evidence of clinical outcomes benefit from randomized trials. Furthermore, emerging data have recently suggested that, in certain situations, morphine and oxygen may actually be associated with harm in the setting of ACS...
May 9, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28583439/incidental-coronary-calcifications-on-routine-chest-ct-clinical-implications
#8
REVIEW
Michael N Pakdaman, Alan Rozanski, Daniel S Berman
Coronary artery calcification (CAC) is a marker of atherosclerosis and an independent risk factor for cardiac-related mortality, with much of the 50% decline in mortality over the past 30 years being attributed to early detection of coronary disease and intervention of modifiable risk factors. With over 10 million computed tomography (CT) examinations of the chest performed in the United States yearly, CAC can be identified in a very large number of patients. In this review, we discuss the clinical evidence underlying the relationship between radiologic identification of CAC, atherosclerosis, and cardiac outcomes and the implications of its assessment on standard chest CT...
April 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28583438/editorial-commentary-endothelial-to-mesenchymal-transition-when-the-good-one-goes-bad
#9
EDITORIAL
Yixuan Zhang, Hua Cai
No abstract text is available yet for this article.
April 26, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28528798/editorial-commentary-importance-of-triglycerides
#10
EDITORIAL
Alan F Jones
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28527539/editorial-commentary-here-today-gone-tomorrow-the-laa-and-stroke
#11
EDITORIAL
Paul A Friedman, David R Holmes
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28501414/editorial-commentary-genetic-contributions-to-cardiovascular-disease-the-blurred-lines-between-monogenic-and-polygenic-traits
#12
EDITORIAL
Jodie Ingles, J Martijn Bos
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28457612/improving-our-understanding-of-type-2-myocardial-infarction-and-myocardial-injury
#13
EDITORIAL
Yader Sandoval
No abstract text is available yet for this article.
March 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28188081/editorial-commentary-sleep-disordered-breathing-and-cardiovascular-outcomes-is-it-time-to-change-our-thinking
#14
EDITORIAL
Maria R Bonsignore
No abstract text is available yet for this article.
May 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28185710/my-approach-to-the-patient-with-arrhythmogenic-right-ventricular-cardiomyopathy-arvc
#15
Angeliki Asimaki
No abstract text is available yet for this article.
May 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28089339/discovery-of-a-murine-model-of-clinical-pah-mission-impossible
#16
REVIEW
Zhiyu Dai, You-Yang Zhao
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH...
May 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291655/the-cardiovascular-safety-trials-of-dpp-4-inhibitors-glp-1-agonists-and-sglt2-inhibitors
#17
REVIEW
Matthew H Secrest, Jacob A Udell, Kristian B Filion
In this paper, we review the results of large, double-blind, placebo-controlled randomized trials mandated by the US Food and Drug Administration to examine the cardiovascular safety of newly-approved antihyperglycemic agents in patients with type 2 diabetes. The cardiovascular effects of dipeptidyl peptidase-4 (DPP-4) inhibitors remain controversial: while these drugs did not reduce or increase the risk of primary, pre-specified composite cardiovascular outcomes, one DPP-4 inhibitor (saxagliptin) increased the risk of hospitalization for heart failure in the overall population; another (alogliptin) demonstrated inconsistent effects on heart failure hospitalization across subgroups of patients, and a third (sitagliptin) demonstrated no effect on heart failure...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27717538/non-invasive-assessment-of-low-and-intermediate-risk-patients-with-chest-pain
#18
REVIEW
Pelbreton C Balfour, Jorge A Gonzalez, Christopher M Kramer
Coronary artery disease (CAD) remains a significant global public health burden despite advancements in prevention and therapeutic strategies. Common non-invasive imaging modalities, anatomic and functional, are available for the assessment of patients with stable chest pain. Exercise electrocardiography is a long-standing method for evaluation for CAD and remains the initial test for the majority of patients who can exercise adequately with a baseline interpretable electrocardiogram. The addition of cardiac imaging to exercise testing provides incremental benefit for accurate diagnosis for CAD and is particularly useful in patients who are unable to exercise adequately and/or have uninterpretable electrocardiograms...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28461140/laa-occluder-device-for-stroke-prevention-data-on-watchman-and-other-laa-occluders
#19
REVIEW
Martin W Bergmann
NOAC therapy has become the standard for stroke prevention in patients with atrial fibrillation. Yet some patients suffer extracranial bleeding events or have other reasons to seek non-pharmacologic stroke protection. LAA occlusion with the WATCHMAN device has been proven safe and effective for such patients and is now recommended in current guidelines for this patient group; other devices also seek approval.
March 24, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28456354/genetic-association-studies-in-cardiovascular-diseases-do-we-have-enough-power
#20
REVIEW
Paul L Auer, Nathan O Stitziel
Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research in human genetics has enriched our understanding of the pathobiology of CVD. As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results. We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens...
March 24, 2017: Trends in Cardiovascular Medicine
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