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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/29336945/current-treatment-of-significant-left-main-coronary-artery-disease-a-review
#1
REVIEW
Mariama Akodad, Marie-Claude Morice
Though infrequent, left main stenosis has a major prognostic impact. The management of left main disease has evolved over the last few decades with the growing evidence of the efficacy and safety of percutaneous interventions, as attested by the most recent trials. However, mastery of the technical aspects of left main bifurcation stenting is essential in ensuring optimal results. This review focuses on recent data concerning left main angioplasty results as well as the current technical approaches.
January 5, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29336944/editorial-commentary-newborn-screening-for-fabry-disease-too-much-too-soon
#2
EDITORIAL
M Langeveld
No abstract text is available yet for this article.
January 5, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29336946/ldl-cholesterol-how-low-to-go
#3
REVIEW
Chris J Packard
Epidemiology and the results of large-scale outcome trials indicate that the association of LDL with atherosclerotic cardiovascular disease is causal, and continuous not only across levels seen in the general population but also down to sub-physiological values. There is no scientific basis, therefore, to set a target or 'floor' for LDL cholesterol lowering, and this presents a clinical and conceptual dilemma for prescribers, patients, and payers. With the advent of powerful agents such as proprotein convertase/subtilisin kexin type 9 (PCSK9) inhibitors, LDL cholesterol can be lowered profoundly but health economic constraints mandate that this therapeutic approach needs to be selective...
December 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29307779/editorial-commentary-malignant-pvcs-revising-the-idiopathic-label
#4
EDITORIAL
Gregory E Supple
No abstract text is available yet for this article.
December 21, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29301723/brugada-syndrome-or-not-that-is-the-question
#5
EDITORIAL
Guillaume Bassil, Sami F Noujaim
No abstract text is available yet for this article.
December 21, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29292032/ace-inhibition-to-slow-progression-of-myocardial-fibrosis-in-muscular-dystrophies
#6
REVIEW
Vincenzo Russo, Andrea Antonio Papa, Emmanuel Ato Williams, Anna Rago, Alberto Palladino, Luisa Politano, Gerardo Nigro
Muscular dystrophy (MD) connotes a heterogeneous group of inherited disordersaffecting skeletal and cardiac muscle. Inseveral forms of MD, the cardiac disease may be the predominant manifestationof the underlying genetic myopathy. The cardiacinvolvement is due to progressive interstitial fibrosis and fatty replacement inboth the atria and ventricles, which may lead to cardiomyopathy, conductiondefects and tachyarrhythmias. Angiotensin-convertingenzyme inhibitors (ACE-Is) modulate the production of angiotensin II and limitthe amount of fibrosis in the myocardium, reducing mortality andhospitalization in cardiac patients...
December 21, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29277287/editorial-commentary-mitochondrial-autophagy-in-cardiac-aging-is-all-fluxed-up
#7
EDITORIAL
Dieter A Kubli, Mark A Sussman
No abstract text is available yet for this article.
December 19, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29307780/editorial-commentary-obesity-and-heart-failure-with-preserved-ejection-fraction-a-single-disease-or-two-co-existing-conditions
#8
EDITORIAL
Salvatore Carbone, Ambarish Pandey, Carl J Lavie
No abstract text is available yet for this article.
December 14, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29305040/obesity-and-heart-failure-with-preserved-ejection-fraction-a-growing-problem
#9
REVIEW
Stuart B Prenner, Paul J Mather
Heart Failure with Preserved Ejection Fraction (HFpEF) is increasing in prevalence due to the aging of the United States population as well as the current obesity epidemic. While obesity is very common in patients with HFpEF, obesity may represent a specific phenotype of HFpEF characterized by unique hemodynamics and structural abnormalities. Obesity induces a systemic inflammatory response that may contribute to myocardial fibrosis and endothelial dysfunction. The most obese patients continue to be excluded from HFpEF clinical trials, and thus ongoing research is needed to determine the role of pharmacologic and interventional approaches in this growing population...
December 14, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29273184/editorial-commentary-treatment-of-refractory-angina-an-ongoing-challenge
#10
EDITORIAL
Udho Thadani
No abstract text is available yet for this article.
December 12, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29275928/spontaneous-coronary-artery-dissection-scad-the-underdiagnosed-cardiac-condition-that-plagues-women
#11
REVIEW
Sandrine Lebrun, Rachel M Bond
Coronary heart disease (CHD) continues to be understudied, underdiagnosed, and undertreated in women. Gender and age bias complicate the evaluation of women with acute coronary syndrome (ACS). As a result, conditions like spontaneous coronary artery dissection (SCAD) are often missed. SCAD is an infrequent yet important cause of myocardial infarction (MI) with a predilection for young to middle aged women. The condition is thought to be under-reported, likely a result of both low index of suspicion as well as an unfamiliarity with SCAD's angiographic variants...
December 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29269287/editorial-commentary-mathematical-modeling-as-a-tool-to-elucidate-fundamental-principles-in-cardiac-electrophysiology
#12
EDITORIAL
Amara Greer-Short, Thomas J Hund
No abstract text is available yet for this article.
December 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29269286/editorial-commentary-targeting-tymp-for-cardiovascular-disease-how-far-are-we
#13
EDITORIAL
Matteo Vatta
No abstract text is available yet for this article.
December 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29287956/mitochondrial-quality-control-the-role-of-mitophagy-in-aging
#14
REVIEW
Ruoyang Shi, Matthew Guberman, Lorrie A Kirshenbaum
Autophagy is a catabolic process for eliminating macromolecules and damaged organelles by a highly regulated lysosomal pathway. Importantly, autophagy serves as an integral quality control mechanism by recycling cellular constituents for energy consumption and cellular rejuvenation under basal and stress conditions. Nevertheless, there is growing evidence that under certain conditions autophagy can switch from an adaptive survival mechanism to maladaptive process that promotes cell death. Furthermore, defects in autophagy have been linked to mitochondria injury and cell death associated with aging...
December 6, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29254831/idiopathic-malignant-premature-ventricular-contractions
#15
REVIEW
James E Ip, Bruce B Lerman
The presence of premature ventricular contractions (PVCs) in patients with structurally normal hearts was once considered a benign phenomenon. However, in susceptible patients, these "benign" or idiopathic PVCs may develop malignant potential and trigger ventricular fibrillation and result in sudden cardiac death. Alternatively, idiopathic PVCs can also induce cardiomyopathy. Clinical recognition of these entities can lead to effective targeted therapy. In the first instance, treatment consists of ablating the PVC source and implanting a defibrillator, whereas in the second scenario, ablating the PVC origin can normalize left ventricular function...
November 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29221767/editorial-commentary-interpreting-and-dealing-with-myocardial-stunning
#16
EDITORIAL
Dawod Sharif
No abstract text is available yet for this article.
November 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29254832/controversies-in-brugada-syndrome
#17
REVIEW
Marina Cerrone
The Brugada syndrome is an inherited channelopathy associated with increased risk of ventricular arrhythmias and sudden death, often occurring during sleep or resting conditions. Although this entity has been described more than 20 years ago, it remains one of the most debated among channelopathies, with several open questions on its genetic substrate, arrhythmia mechanisms, and clinical management. Studies on the genetics and physiopathology bases of the Brugada syndrome have opened novel investigative pathways and concepts that are now entering the field of cardiovascular genetics and are applied to other inherited arrhythmias...
November 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29221768/current-interpretation-of-myocardial-stunning
#18
REVIEW
Andrea Igoren Guaricci, Gabriella Bulzis, Gianluca Pontone, Pietro Scicchitano, Rossella Carbonara, Mark Rabbat, Delia De Santis, Marco Matteo Ciccone
Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning. Possible underlying mechanisms include an oxyradical hypothesis, calcium overload, decreased responsiveness of myofilaments to calcium, and excitation-contraction uncoupling due to sarcoplasmic reticulum dysfunction...
November 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29203397/pro-arrhythmic-effects-of-low-plasma-k-in-human-ventricle-an-illustrated-review
#19
REVIEW
Beatriz Trenor, Karen Cardona, Lucia Romero, Juan F Gomez, Javier Saiz, Sridharan Rajamani, Luiz Belardinelli, Wayne Giles
Potassium levels in the plasma, [K+]o, are regulated precisely under physiological conditions. However, increases (from approx. 4.5 to 8.0mM) can occur as a consequence of, e.g., endurance exercise, ischemic insult or kidney failure. This hyperkalemic modulation of ventricular electrophysiology has been studied extensively. Hypokalemia is also common. It can occur in response to diuretic therapy, following renal dialysis, or during recovery from endurance exercise. In the human ventricle, clinical hypokalemia (e...
November 24, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29150185/editorial-commentary-for-dhakal-heart-failure-in-systemic-lupus-erythematosus-a-problem-to-address
#20
EDITORIAL
Kai-Hang Yiu, Hung-Fat Tse
No abstract text is available yet for this article.
November 8, 2017: Trends in Cardiovascular Medicine
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