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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/28528798/editorial-commentary-importance-of-triglycerides
#1
EDITORIAL
Alan F Jones
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28527539/editorial-commentary-here-today-gone-tomorrow-the-laa-and-stroke
#2
EDITORIAL
Paul A Friedman, David R Holmes
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28501414/editorial-commentary-genetic-contributions-to-cardiovascular-disease-the-blurred-lines-between-monogenic-and-polygenic-traits
#3
EDITORIAL
Jodie Ingles, J Martijn Bos
No abstract text is available yet for this article.
April 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28457612/improving-our-understanding-of-type-2-myocardial-infarction-and-myocardial-injury
#4
EDITORIAL
Yader Sandoval
No abstract text is available yet for this article.
March 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28461140/laa-occluder-device-for-stroke-prevention-data-on-watchman-and-other-laa-occluders
#5
REVIEW
Martin W Bergmann
NOAC therapy has become the standard for stroke prevention in patients with atrial fibrillation. Yet some patients suffer extracranial bleeding events or have other reasons to seek non-pharmacologic stroke protection. LAA occlusion with the WATCHMAN device has been proven safe and effective for such patients and is now recommended in current guidelines for this patient group; other devices also seek approval.
March 24, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28456354/genetic-association-studies-in-cardiovascular-diseases-do-we-have-enough-power
#6
REVIEW
Paul L Auer, Nathan O Stitziel
Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research in human genetics has enriched our understanding of the pathobiology of CVD. As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results. We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens...
March 24, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438398/triglycerides-a-reappraisal
#7
REVIEW
Philipp Wiesner, Karol E Watson
Elevated cholesterol levels are clearly independently associated with adverse cardiovascular events. Another class of lipid particles, triglycerides, is also abundant in the human body and has been found in atherosclerotic plaques. Recent observational studies have demonstrated an association between elevated triglyceride levels and increased risk for future cardiovascular events. With this knowledge and the discovery of effective agents to lower triglyceride levels, the management of triglycerides is currently undergoing a renaissance...
March 21, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438397/endothelial-to-mesenchymal-transition-a-novel-therapeutic-target-for-cardiovascular-diseases
#8
REVIEW
Ampadu O Jackson, Jingjing Zhang, Zhisheng Jiang, Kai Yin
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic phenotype. Similar to epithelial-to-mesenchymal transition (EMT), EndMT can be induced by multiple stimulants such as cytokines and metabolic factors that play crucial roles in the development of the cardiovascular system. Recent studies have demonstrated that EndMT may play a significant role in the pathogenesis of cardiovascular diseases (CVDs), and may represent a novel therapeutic target for cardiovascular remodeling and fibrotic disorders...
March 16, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438399/type-2-myocardial-infarction-due-to-supply-demand-mismatch
#9
REVIEW
Nino Mihatov, James L Januzzi, Hanna K Gaggin
The best-accepted definition of myocardial infarction (MI) is provided by statements from the Universal Definition of MI Global Task force. This article, now in its third iteration, defines MI as myocardial cell death due to prolonged myocardial ischemia. It further delineates an increasingly incident subclassification of MI known as type 2 MI (T2MI). T2MI identifies instances of myocardial necrosis in which an imbalance between myocardial oxygen supply and/or demand occurs for reasons other than atherosclerotic plaque disruption...
March 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28392173/editorial-commentary-cardiac-rehabilitation-major-benefits-and-minor-risks
#10
EDITORIAL
Jennifer G Foster, Steven F Lewis, Charles H Hennekens
No abstract text is available yet for this article.
March 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28351697/non-invasive-assessment-of-myocardial-fibrosis-focus-on-the-substrate-of-ventricular-arrhythmias-to-improve-risk-stratification
#11
EDITORIAL
Andrea Di Marco
No abstract text is available yet for this article.
February 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28351696/new-drugs-for-diabetes-finally-safety-and-cardiovascular-efficacy
#12
EDITORIAL
Kim A Connelly
No abstract text is available yet for this article.
February 27, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28089339/discovery-of-a-murine-model-of-clinical-pah-mission-impossible
#13
REVIEW
Zhiyu Dai, You-Yang Zhao
Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH...
May 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291655/the-cardiovascular-safety-trials-of-dpp-4-inhibitors-glp-1-agonists-and-sglt2-inhibitors
#14
REVIEW
Matthew H Secrest, Jacob A Udell, Kristian B Filion
In this paper, we review the results of large, double-blind, placebo-controlled randomized trials mandated by the US Food and Drug Administration to examine the cardiovascular safety of newly-approved antihyperglycemic agents in patients with type 2 diabetes. The cardiovascular effects of dipeptidyl peptidase-4 (DPP-4) inhibitors remain controversial: while these drugs did not reduce or increase the risk of primary, pre-specified composite cardiovascular outcomes, one DPP-4 inhibitor (saxagliptin) increased the risk of hospitalization for heart failure in the overall population; another (alogliptin) demonstrated inconsistent effects on heart failure hospitalization across subgroups of patients, and a third (sitagliptin) demonstrated no effect on heart failure...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27717538/non-invasive-assessment-of-low-and-intermediate-risk-patients-with-chest-pain
#15
REVIEW
Pelbreton C Balfour, Jorge A Gonzalez, Christopher M Kramer
Coronary artery disease (CAD) remains a significant global public health burden despite advancements in prevention and therapeutic strategies. Common non-invasive imaging modalities, anatomic and functional, are available for the assessment of patients with stable chest pain. Exercise electrocardiography is a long-standing method for evaluation for CAD and remains the initial test for the majority of patients who can exercise adequately with a baseline interpretable electrocardiogram. The addition of cardiac imaging to exercise testing provides incremental benefit for accurate diagnosis for CAD and is particularly useful in patients who are unable to exercise adequately and/or have uninterpretable electrocardiograms...
April 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28318815/the-role-of-cardiac-rehabilitation-in-patients-with-heart-disease
#16
REVIEW
Sean R McMahon, Philip A Ades, Paul D Thompson
Cardiac rehabilitation is a valuable treatment for patients with a broad spectrum of cardiac disease. Current guidelines support its use in patients after acute coronary syndrome, coronary artery bypass grafting, coronary stent placement, valve surgery, and stable chronic systolic heart failure. Its use in these conditions is supported by a robust body of research demonstrating improved clinical outcomes. Despite this evidence, cardiac rehabilitation referral and attendance remains low and interventions to increase its use need to be developed...
February 15, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291653/lifestyle-and-life-long-lasting-cardiovascular-health
#17
EDITORIAL
Luis A Moreno
No abstract text is available yet for this article.
February 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28274655/high-sensitive-troponin-a-new-tool-for-clinical-decision-making-in-valvular-heart-disease
#18
EDITORIAL
Johanne Frank, Norbert Frey, Derk Frank
No abstract text is available yet for this article.
February 8, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28291654/comments-on-letter-to-the-editor-entitled-role-of-electrophysiological-evaluation-for-the-best-device-choice-to-prevent-sudden-cardiac-death-in-patients-with-myotonic-dystrophy-type1-and-emery-dreifuss-muscular-dystrophy
#19
LETTER
R B Sommerville, M G Vincenti, K Winborn, A Casey, N O Stitziel, A M Connolly, D L Mann
No abstract text is available yet for this article.
February 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28237579/role-of-electrophysiological-evaluation-for-the-best-device-choice-to-prevent-sudden-cardiac-death-in-patients-with-myotonic-dystrophy-type-1-and-emery-dreifuss-muscular-dystrophy
#20
LETTER
Vincenzo Russo, Luisa Politano, Gerardo Nigro
No abstract text is available yet for this article.
February 5, 2017: Trends in Cardiovascular Medicine
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