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Trends in Cardiovascular Medicine

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https://www.readbyqxmd.com/read/28739313/cardiac-amyloidosis-an-update-on-pathophysiology-diagnosis-and-treatment
#1
REVIEW
Omar K Siddiqi, Frederick L Ruberg
The amyloidoses are a group of systemic diseases characterized by organ deposition of misfolded protein fragments of diverse origins. The natural history of the disease, involvement of other organs, and treatment options vary significantly based on the protein of origin. In AL amyloidosis, amyloid protein is derived from immunoglobulin light chains, and most often involves the kidneys and the heart. ATTR amyloidosis is categorized as mutant or wild-type depending on the genetic sequence of the transthyretin (TTR) protein produced by the liver...
July 13, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28734594/editorial-commentary-closure-of-the-patent-foramen-ovale-viewed-from-a-different-angle
#2
EDITORIAL
Bernhard Meier, Fabian Nietlispach
No abstract text is available yet for this article.
July 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28735783/myocardial-viability-state-of-the-art-is-it-still-relevant-and-how-to-best-assess-it-with-imaging
#3
REVIEW
Hena Patel, Wojciech Mazur, Kim Allan Williams, Dinesh K Kalra
Despite major advances, ischemic cardiomyopathy (ICM) remains a significant cause of death and disability worldwide, with coronary artery disease (CAD) the leading cause of left ventricular (LV) systolic dysfunction. Coronary revascularization may improve LV function, heart failure symptoms and cardiovascular outcomes in high-risk patients with myocardial viability. Multiple imaging modalities have been utilized to detect viable myocardium and predict functional recovery following revascularization. Dobutamine stress echocardiography (DSE), nuclear imaging and cardiac MRI (CMR) are frequently used to assess viability...
July 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28735782/editorial-commentary-keeping-the-congenitally-malformed-heart-in-shape
#4
EDITORIAL
Gert van den Berg, Thomas Krasemann, Alex V Postma
No abstract text is available yet for this article.
July 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28734595/arrhythmias-after-left-ventricular-assist-device-implantation-incidence-and-management
#5
REVIEW
Anis J Kadado, Joseph G Akar, James P Hummel
The use of mechanical circulatory support has become an increasingly common practice in patients with heart failure, whether used as bridge to transplantation or as destination therapy. The last couple of decades has seen a drastic change in the functioning of the left ventricular assist devices (LVAD), changing from the first generation devices running on pulsatile flow to the current continuous flow devices. Atrial and ventricular arrhythmias are common among heart failure patients, and though the systematic circulation is well supported in patients on mechanical circulatory support, these arrhythmias can still be the cause of detrimental symptoms and lead to potentially fatal outcomes...
July 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28716506/how-to-prevent-burnout-in-cardiologists-a-review-of-the-current-evidence-gaps-and-future-directions
#6
REVIEW
Maria Panagioti, Keith Geraghty, Judith Johnson
Burnout is rising in all physicians, and cardiologists are not an exemption. Cardiology is a very popular specialty among medical students as it is associated with outstanding training standards and high prestige and income. In this review, we critically summarize the evidence on consequences, causes, and evidence-based interventions for burnout with a view toward recommending the best strategies for promoting wellness in cardiologists. Only a handful of studies have examined burnout specifically in cardiologists...
July 4, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709812/patent-foramen-ovale-and-cryptogenic-stroke
#7
REVIEW
Koki Nakanishi, Minoru Yoshiyama, Shunichi Homma
The presence of a patent foramen ovale (PFO) has been found to be associated with an increased risk of cryptogenic stroke in many case-control studies. This paper reviews the current understanding of the pathophysiology and diagnosis of PFO, and therapeutic options of patients with PFO and cryptogenic stroke.
July 4, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709810/editorial-commentary-optimization-of-dose-selection-for-nonvitamin-k-antagonist-oral-anticoagulants
#8
EDITORIAL
James E Tisdale
No abstract text is available yet for this article.
June 30, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709813/editorial-commentary-where-do-we-stand-after-danish-its-tough-to-make-predictions-especially-about-the-future
#9
EDITORIAL
Raul D Mitrani, Jeffrey J Goldberger
No abstract text is available yet for this article.
June 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28739312/editorial-commentary-indications-for-catheter-ablation-of-ventricular-tachycardia-in-the-modern-era
#10
EDITORIAL
Basil Saour, Bradley P Knight
No abstract text is available yet for this article.
June 20, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28684210/my-approach-to-the-patient-with-a-borderline-long-qt-interval
#11
Thomas Roston, Andrew D Krahn
No abstract text is available yet for this article.
June 13, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28735784/cardiovascular-effects-of-alcohol-consumption
#12
REVIEW
J├╝rgen Rehm, Michael Roerecke PhD
Alcohol consumption has a major but complex impact on cardiovascular diseases. Both irregular and chronic heavy drinking occasions detrimentally impact on most major cardiovascular disease categories, whereas light to moderate drinking has been associated with beneficial effects on ischemic heart disease and ischemic stroke. Both detrimental and beneficial effects of alcohol consumption have been corroborated by biochemical pathways. The impact of alcohol consumption on cardiovascular disease should be evaluated within the context of other effects of alcohol on health...
June 10, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709809/editorial-commentary-tuning-in-to-sympathetic-activity-cutaneously-in-humans-a-bench-to-bedside-saga
#13
EDITORIAL
Richard L Verrier
No abstract text is available yet for this article.
June 9, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709808/editorial-commentary-important-contributions-of-basic-electrophysiology-to-the-prevention-and-therapy-of-drug-induced-cardiac-arrhythmias
#14
EDITORIAL
Andrew L Wit
No abstract text is available yet for this article.
June 9, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28709811/arrhythmic-risk-stratification-in-non-ischemic-dilated-cardiomyopathy-where-do-we-stand-after-danish
#15
REVIEW
Polychronis Dilaveris, Christos-Konstantinos Antoniou, Konstantinos A Gatzoulis
Publication of the DANISH randomized trial led to considerable debate, given that it demonstrated no survival benefit stemming from current implantable cardioverter-defibrillator (ICD) allocation criteria in patients with non-ischemic dilated cardiomyopathy (NIDCM). Consequently, a thorough reconsideration of our approach to sudden cardiac death (SCD)-risk stratification appears to be in order. NIDCM encompasses a wide spectrum of disease entities, often with differing arrhythmogenicity; however, in its kernel, is still defined by the fundamentals of electrophysiology that dictate that abnormal tissue, exhibiting altered electrophysiological properties is necessary for arrhythmogenesis, but not enough, given that formation of functional circuits is required...
June 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28601251/reprint-of-editiorial-commentary-genomics-and-drug-discovery-the-next-frontier-in-precision-medicine
#16
EDITORIAL
Dan M Roden
No abstract text is available yet for this article.
June 7, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28687226/acquired-long-qt-syndrome-and-phosphoinositide-3-kinase
#17
REVIEW
Ira S Cohen, Richard Z Lin, Lisa M Ballou
While it is well known that mutation of several different ion channels can cause congenital long QT syndrome, block of IKr is widely thought to be responsible for most cases of drug-induced acquired long QT syndrome (aLQTS). In this article, we review evidence supporting another cause of aLQTS due to inhibition of phosphoinositide 3-kinase (PI3K) signaling. Inhibition of PI3K affects multiple plateau currents, reducing IKr, IKs, and ICaL while increasing the persistent sodium current (INaP). The effects of PI3K inhibitors develop slowly, requiring hours to days to reach steady state...
May 17, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28629865/editorial-commentary-coronary-artery-calcification-on-non-cardiac-chest-ct-incidental-but-impactful
#18
EDITORIAL
Aalap Chokshi, James E Udelson
No abstract text is available yet for this article.
May 16, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28623083/editorial-commentary-atrial-fibrillation-challenges-and-opportunities
#19
EDITORIAL
Heikki V Huikuri
No abstract text is available yet for this article.
May 15, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28625728/treatment-of-persistent-ventricular-tachycardia-drugs-or-ablation
#20
REVIEW
Ciorsti J MacIntyre, John L Sapp
Implantable cardioverter defibrillators (ICDs) reduce the mortality risk associated with recurrent ventricular tachycardia (VT) and can frequently terminate VT episodes painlessly, but do not prevent recurrent episodes. For patients with symptomatic recurrences, frequent asymptomatic recurrences, ICD shocks, or VT storm, most clinicians recommend strategies to suppress VT. The proarrhythmic mortality risk of antiarrhythmic drugs (AADs) may be mitigated by the presence of an ICD, but these medications are limited by high recurrence rates, and unfavorable side effect profiles...
May 10, 2017: Trends in Cardiovascular Medicine
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