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Journal of Psychiatry & Neuroscience: JPN

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https://www.readbyqxmd.com/read/29952748/resting-state-functional-connectivity-in-individuals-with-bipolar-disorder-during-clinical-remission-a-systematic-review
#1
Sabrina K Syan, Mara Smith, Benicio N Frey, Raheem Remtulla, Flavio Kapczinski, Geoffrey B C Hall, Luciano Minuzzi
BACKGROUND: Bipolar disorder is chronic and debilitating. Studies investigating resting-state functional connectivity in individuals with bipolar disorder may help to inform neurobiological models of illness. METHODS: We conducted a systematic review with the following goals: to summarize the literature on resting-state functional connectivity in bipolar disorder during clinical remission (euthymia) compared with healthy controls; to critically appraise the literature and research gaps; and to propose directions for future research...
June 28, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29952747/psychoradiological-patterns-of-small-world-properties-and-a-systematic-review-of-connectome-studies-of-patients-with-6-major-psychiatric-disorders
#2
Xueling Suo, Du Lei, Lei Li, Wenbin Li, Jing Dai, Song Wang, Manxi He, Hongyan Zhu, Graham J Kemp, Qiyong Gong
BACKGROUND: Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder...
June 28, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29924721/a-negative-association-between-brainstem-pontine-grey-matter-volume-well-being-and-resilience-in-healthy-twins
#3
Justine M Gatt, Karen L O Burton, Kylie M Routledge, Katrina L Grasby, Mayuresh S Korgaonkar, Stuart M Grieve, Peter R Schofield, Anthony W F Harris, C Richard Clark, Leanne M Williams
BACKGROUND: Associations between well-being, resilience to trauma and the volume of grey-matter regions involved in affective processing (e.g., threat/reward circuits) are largely unexplored, as are the roles of shared genetic and environmental factors derived from multivariate twin modelling. METHODS: This study presents, to our knowledge, the first exploration of well-being and volumes of grey-matter regions involved in affective processing using a region-of-interest, voxel-based approach in 263 healthy adult twins (60% monozygotic pairs, 61% females, mean age 39...
June 20, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29894286/low-white-matter-integrity-between-the-left-thalamus-and-inferior-frontal-gyrus-in-patients-with-insomnia-disorder
#4
Jae Myeong Kang, Sung Woo Joo, Young-Don Son, Hyun Kim, Kwang-Pil Ko, Jung Sun Lee, Seung-Gul Kang
BACKGROUND: Previous studies have reported functional and structural abnormalities in the thalamus and the pars triangularis of the inferior frontal gyrus in patients with insomnia disorder. However, no studies have been conducted on the white-matter tracts between these 2 brain regions. We aimed to compare the white-matter integrity and structure of the left thalamus-pars triangularis tracts between patients with insomnia and controls, and to characterize the relationship between white-matter integrity and clinical features in patients with insomnia...
June 12, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29889658/abnormal-protein-and-mrna-expression-of-inflammatory-cytokines-in-the-prefrontal-cortex-of-depressed-individuals-who-died-by-suicide
#5
Ghanshyam N Pandey, Hooriyah S Rizavi, Hui Zhang, Runa Bhaumik, Xinguo Ren
BACKGROUND: Depression and stress are major risk factors for suicidal behaviour, and some studies show abnormalities of proinflammatory cytokines in the serum and cerebrospinal fluid (CSF) of depressed and suicidal patients. However, it is not clear if similar abnormalities of cytokines are present in the brain of suicidal and depressed patients. METHODS: We therefore determined the mRNA (using real-time polymerase chain reaction) and protein (using enzyme-linked immunosorbent assay and Western Blot) expression levels of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α, lymphotoxin A, lymphotoxin B, IL-8, IL-10 and IL-13 in the prefrontal cortex (PFC) obtained from 24 depressed individuals who died by suicide and 24 nonpsychiatric controls...
June 11, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29877178/white-matter-network-alterations-in-patients-with-depersonalization-derealization-disorder
#6
Anika Sierk, Judith K Daniels, Antje Manthey, Jelmer G Kok, Alexander Leemans, Michael Gaebler, Jan-Peter Lamke, Johann Kruschwitz, Henrik Walter
BACKGROUND: Depersonalization/derealization disorder (DPD) is a chronic and distressing condition characterized by detachment from oneself and/or the external world. Neuroimaging studies have associated DPD with structural and functional alterations in a variety of distinct brain regions. Such local neuronal changes might be mediated by altered interregional white matter connections. However, to our knowledge, no research on network characteristics in this patient population exists to date...
June 6, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29848411/low-levels-of-muscarinic-m1-receptor-positive-neurons-in-cortical-layers-iii-and-v-in-brodmann-areas-9-and-17-from-individuals-with-schizophrenia
#7
Elizabeth Scarr, Shaun Hopper, Valentina Vos, Myoung Suk Seo, Ian Paul Everall, Timothy Douglas Aumann, Gursharan Chunam, Brian Dean
BACKGROUND: Results of neuroimaging and postmortem studies suggest that people with schizophrenia may have lower levels of muscarinic M1 receptors (CHRM1) in the cortex, but not in the hippocampus or thalamus. Here, we use a novel immunohistochemical approach to better understand the likely cause of these low receptor levels. METHODS: We determined the distribution and number of CHRM1-positive (CHRM1+) neurons in the cortex, medial dorsal nucleus of the thalamus and regions of the hippocampus from controls ( n = 12, 12 and 5, respectively) and people with schizophrenia ( n = 24, 24 and 13, respectively)...
May 30, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29808791/genetic-variability-in-scaffolding-proteins-and-risk-for-schizophrenia-and-autism-spectrum-disorders-a-systematic-review
#8
Jordi Soler, Lourdes Fañanás, Mara Parellada, Marie-Odile Krebs, Guy A Rouleau, Mar Fatjó-Vilas
Scaffolding proteins represent an evolutionary solution to controlling the specificity of information transfer in intracellular networks. They are highly concentrated in complexes located in specific subcellular locations. One of these complexes is the postsynaptic density of the excitatory synapses. There, scaffolding proteins regulate various processes related to synaptic plasticity, such as glutamate receptor trafficking and signalling, and dendritic structure and function. Most scaffolding proteins can be grouped into 4 main families: discs large (DLG), discs-large-associated protein (DLGAP), Shank and Homer...
May 28, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29767624/the-maternal-brain-in-women-with-a-history-of-early-life-maltreatment-an-imagination-based-fmri-study-of-conflictual-versus-pleasant-interactions-with-children
#9
Corinne Neukel, Katja Bertsch, Anna Fuchs PhD, Anna-Lena Zietlow, Corinna Reck, Eva Moehler, Romuald Brunner, Felix Bermpohl, Sabine C Herpertz
BACKGROUND: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions. METHODS: In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task...
May 16, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29717977/a-study-of-novel-bilateral-thermal-capsulotomy-with-focused-ultrasound-for-treatment-refractory-obsessive-compulsive-disorder-2-year-follow-up
#10
Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Jin Woo Chang
BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years...
May 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947611/social-anxiety-disorder-in-schizophrenia-a-neglected-yet-potentially-important-comorbidity
#11
Marc-André Roy, Marie-France Demers, Amélie M Achim
No abstract text is available yet for this article.
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947610/the-maternal-brain-in-women-with-a-history-of-early-life-maltreatment-an-imagination-based-fmri-study-of-conflictual-versus-pleasant-interactions-with-children
#12
Corinne Neukel, Katja Bertsch, Anna Fuchs, Anna-Lena Zietlow, Corinna Reck, Eva Moehler, Romuald Brunner, Felix Bermpohl, Sabine C Herpertz
BACKGROUND: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions. METHODS: In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task...
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947609/abnormal-dynamic-functional-connectivity-of-amygdalar-subregions-in-untreated-patients-with-first-episode-major-depressive-disorder
#13
Lihua Qiu, Mingrui Xia, Bochao Cheng, Lin Yuan, Weihong Kuang, Feng Bi, Hua Ai, Zhongwei Gu, Su Lui, Xiaoqi Huang, Yong He, Qiyong Gong
BACKGROUND: Accumulating evidence supports the concept of the amygdala as a complex of structurally and functionally heterogeneous nuclei rather than as a single homogeneous structure. However, changes in resting-state functional connectivity in amygdalar subregions have not been investigated in major depressive disorder (MDD). Here, we explored whether amygdalar subregions - including the laterobasal, centromedial (CM) and superficial (SF) areas - exhibited distinct disruption patterns for different dynamic functional connectivity (dFC) properties, and whether these different properties were correlated with clinical information in patients with MDD...
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947608/correction-enhanced-corticobulbar-excitability-in-chronic-smokers-during-visual-exposure-to-cigarette-smoking-cues
#14
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947607/effects-of-extended-release-naltrexone-on-the-brain-response-to-drug-related-stimuli-in-patients-with-opioid-use-disorder
#15
Zhenhao Shi, An-Li Wang, Kanchana Jagannathan, Victoria P Fairchild, Charles P O'Brien, Anna Rose Childress, Daniel D Langleben
BACKGROUND: Heightened response to drug-related cues is a hallmark of addiction. Extended-release naltrexone (XR-NTX) is a US Food and Drug Administration-approved pharmacotherapy for relapse prevention in patients with opioid use disorder (OUD). In these patients, XR-NTX has been shown to reduce brain responses to opioid-related visual stimuli. To assess the biomarker potential of this phenomenon, it is necessary to determine whether this effect is limited to opioid-related stimuli and whether it is associated with key OUD symptoms...
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947606/examining-cognition-across-the-bipolar-schizophrenia-diagnostic-spectrum
#16
Amy J Lynham, Leon Hubbard, Katherine E Tansey, Marian L Hamshere, Sophie E Legge, Michael J Owen, Ian R Jones, James T R Walters
BACKGROUND: Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder. We hypothesized that there is a spectrum of increasing impairment from bipolar disorder to schizoaffective disorder bipolar type, to schizoaffective disorder depressive type and schizophrenia. METHODS: We compared performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery between participants with schizophrenia ( n = 558), schizoaffective disorder depressive type ( n = 112), schizoaffective disorder type ( n = 76), bipolar disorder ( n = 78) and healthy participants ( n = 103) using analysis of covariance with post hoc comparisons...
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947605/genetic-variability-in-scaffolding-proteins-and-risk-for-schizophrenia-and-autism-spectrum-disorders-a-systematic-review
#17
Jordi Soler, Lourdes Fañanás, Mara Parellada, Marie-Odile Krebs, Guy A Rouleau, Mar Fatjó-Vilas
Scaffolding proteins represent an evolutionary solution to controlling the specificity of information transfer in intracellular networks. They are highly concentrated in complexes located in specific subcellular locations. One of these complexes is the postsynaptic density of the excitatory synapses. There, scaffolding proteins regulate various processes related to synaptic plasticity, such as glutamate receptor trafficking and signalling, and dendritic structure and function. Most scaffolding proteins can be grouped into 4 main families: discs large (DLG), discs-large-associated protein (DLGAP), Shank and Homer...
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29947604/are-people-with-psychiatric-disorders-violent
#18
Marco Leyton
No abstract text is available yet for this article.
July 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688878/dispensary-cannabidiol-marijuana-and-first-episode-mania
#19
Zahinoor Ismail
No abstract text is available yet for this article.
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688877/canadian-college-of-neuropsychopharmacology-2018-award-winners
#20
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Journal of Psychiatry & Neuroscience: JPN
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