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Journal of Psychiatry & Neuroscience: JPN

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https://www.readbyqxmd.com/read/29767624/the-maternal-brain-in-women-with-a-history-of-early-life-maltreatment-an-imagination-based-fmri-study-of-conflictual-versus-pleasant-interactions-with-children
#1
Corinne Neukel, Katja Bertsch, Anna Fuchs PhD, Anna-Lena Zietlow, Corinna Reck, Eva Moehler, Romuald Brunner, Felix Bermpohl, Sabine C Herpertz
BACKGROUND: Early-life maltreatment has severe consequences for the affected individual, and it has an impact on the next generation. To improve understanding of the intergenerational effects of abuse, we investigated the consequences of early-life maltreatment on maternal sensitivity and associated brain mechanisms during mother-child interactions. METHODS: In total, 47 mothers (22 with a history of physical and/or sexual childhood abuse and 25 without, all without current mental disorders) took part in a standardized real-life interaction with their 7- to 11-year-old child (not abused) and a subsequent functional imaging script-driven imagery task...
May 16, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29717977/a-study-of-novel-bilateral-thermal-capsulotomy-with-focused-ultrasound-for-treatment-refractory-obsessive-compulsive-disorder-2-year-follow-up
#2
Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Jin Woo Chang
BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years...
May 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688170/are-people-with-psychiatric-disorders-violent
#3
Marco Leyton
No abstract text is available yet for this article.
April 24, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29634476/abnormal-dynamic-functional-connectivity-of-amygdalar-subregions-in-untreated-patients-with-first-episode-major-depressive-disorder
#4
Lihua Qiu, Mingrui Xia, Bochao Cheng, Lin Yuan, Weihong Kuang, Feng Bi, Hua Ai, Zhongwei Gu, Su Lui, Xiaoqi Huang, Yong He, Qiyong Gong
BACKGROUND: Accumulating evidence supports the concept of the amygdala as a complex of structurally and functionally heterogeneous nuclei rather than as a single homogeneous structure. However, changes in resting-state functional connectivity in amygdalar subregions have not been investigated in major depressive disorder (MDD). Here, we explored whether amygdalar subregions - including the laterobasal, centromedial (CM) and superficial (SF) areas - exhibited distinct disruption patterns for different dynamic functional connectivity (dFC) properties, and whether these different properties were correlated with clinical information in patients with MDD...
April 10, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29620519/neurocognitive-emotional-and-neuroendocrine-correlates-of-exposure-to-sexual-assault-in-women
#5
Yann Quidé, Helen Cléry, Frédéric Andersson, Céline Descriaud, Pauline Saint-Martin, Laurent Barantin, Valérie Gissot, Marie-Paule Carrey Le Bas, Sylvie Osterreicher, Diane Dufour-Rainfray, Bruno Brizard, Maja Ogielska, Wissam El-Hage
BACKGROUND: Survivors of sexual assault are vulnerable to long-term negative psychological and physical health outcomes, but few studies have investigated changes in cognition, emotional processing and brain function in the early stages after sexual assault. We used a multimodal approach to identify the cognitive and emotional correlates associated with sexual assault in women. METHODS: Twenty-seven female survivors of sexual assault were included within 4 weeks of the traumatic event, and they were compared with 20 age-matched controls...
April 5, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29620518/examining-cognition-across-the-bipolar-schizophrenia-diagnostic-spectrum
#6
Amy J Lynham, Leon Hubbard, Katherine E Tansey, Marian L Hamshere, Sophie E Legge, Michael J Owen, Ian R Jones, James T R Walters
BACKGROUND: Cognitive impairments are well-established features of schizophrenia, but there is ongoing debate about the nature and degree of cognitive impairment in patients with schizoaffective disorder and bipolar disorder. We hypothesized that there is a spectrum of increasing impairment from bipolar disorder to schizoaffective disorder bipolar type, to schizoaffective disorder depressive type and schizophrenia. METHODS: We compared performance on the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery between participants with schizophrenia ( n = 558), schizoaffective disorder depressive type ( n = 112), schizoaffective disorder type ( n = 76), bipolar disorder ( n = 78) and healthy participants ( n = 103) using analysis of covariance with post hoc comparisons...
April 5, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29485031/effects-of-extended-release-naltrexone-on-the-brain-response-to-drug-related-stimuli-in-patients-with-opioid-use-disorder
#7
Zhenhao Shi, An-Li Wang, Kanchana Jagannathan, Victoria P Fairchild, Charles P O'Brien, Anna Rose Childress, Daniel D Langleben
BACKGROUND: Heightened response to drug-related cues is a hallmark of addiction. Extended-release naltrexone (XR-NTX) is a US Food and Drug Administration-approved pharmacotherapy for relapse prevention in patients with opioid use disorder (OUD). In these patients, XR-NTX has been shown to reduce brain responses to opioid-related visual stimuli. To assess the biomarker potential of this phenomenon, it is necessary to determine whether this effect is limited to opioid-related stimuli and whether it is associated with key OUD symptoms...
February 23, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688878/dispensary-cannabidiol-marijuana-and-first-episode-mania
#8
Zahinoor Ismail
No abstract text is available yet for this article.
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688877/canadian-college-of-neuropsychopharmacology-2018-award-winners
#9
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688876/neuroanatomical-phenotypes-in-mental-illness-identifying-convergent-and-divergent-cortical-phenotypes-across-autism-adhd-and-schizophrenia
#10
Min Tae M Park, Armin Raznahan, Philip Shaw, Nitin Gogtay, Jason P Lerch, M Mallar Chakravarty
BACKGROUND: There is evidence suggesting neuropsychiatric disorders share genomic, cognitive and clinical features. Here, we ask if autism-spectrum disorders (ASD), attention-deficit/hyperactivity disorder (ADHD) and schizophrenia share neuroanatomical variations. METHODS: First, we used measures of cortical anatomy to estimate spatial overlap of neuroanatomical variation using univariate methods. Next, we developed a novel methodology to determine whether cortical deficits specifically target or are "enriched" within functional resting-state networks...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688875/decreased-serum-pyridoxal-levels-in-schizophrenia-meta-analysis-and-mendelian-randomization-analysis
#11
Yukiko Tomioka, Shusuke Numata, Makoto Kinoshita, Hidehiro Umehara, Shin-Ya Watanabe, Masahito Nakataki, Yoshimi Iwayama, Tomoko Toyota, Masashi Ikeda, Hidenaga Yamamori, Shinji Shimodera, Atsushi Tajima, Ryota Hashimoto, Nakao Iwata, Takeo Yoshikawa, Tetsuro Ohmori
BACKGROUND: Alterations in one-carbon metabolism have been associated with schizophrenia, and vitamin B6 is one of the key components in this pathway. METHODS: We first conducted a case-control study of serum pyridoxal levels and schizophrenia in a large Japanese cohort ( n = 1276). Subsequently, we conducted a meta-analysis of association studies ( n = 2125). Second, we investigated whether rs4654748, which was identified in a genome-wide association study as a vitamin B6-related single nucleotide polymorphism, was genetically implicated in patients with schizophrenia in the Japanese population ( n = 10 689)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688874/a-putative-electrophysiological-biomarker-of-auditory-sensory-memory-encoding-is-sensitive-to-pharmacological-alterations-of-excitatory-inhibitory-balance-in-male-macaque-monkeys
#12
William B Holliday, Kate Gurnsey, Robert A Sweet, Tobias Teichert
BACKGROUND: The amplitude of the auditory evoked N1 component that can be derived from noninvasive electroencephalographic recordings increases as a function of time between subsequent tones. N1 amplitudes in individuals with schizophrenia saturate at a lower asymptote, thus giving rise to a reduced dynamic range. Reduced N1 dynamic range is a putative electrophysiological biomarker of altered sensory memory function in individuals with the disease. To date, it is not clear what determines N1 dynamic range and what causes reduced N1 dynamic range in individuals with schizophrenia...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688873/assessing-the-marks-of-change-how-psychotherapy-alters-the-brain-structure-in-women-with-borderline-personality-disorder
#13
Falk Mancke, Ruth Schmitt, Dorina Winter, Inga Niedtfeld, Sabine C Herpertz, Christian Schmahl
BACKGROUND: There is increasing evidence that psychotherapy can alter the function of the brain of patients with borderline personality disorder (BPD). However, it is not known whether psychotherapy can also modify the brain structure of patients with BPD. METHODS: We used structural MRI data of female patients with BPD before and after participation in 12 weeks of residential dialectical behavioural therapy (DBT) and compared them to data from female patients with BPD who received treatment as usual (TAU)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688872/neural-correlates-of-emotional-action-control-in-anger-prone-women-with-borderline-personality-disorder
#14
Katja Bertsch, Karin Roelofs, Paul Jonathan Roch, Bo Ma, Saskia Hensel, Sabine C Herpertz, Inge Volman
BACKGROUND: Difficulty in controlling emotional impulses is a crucial component of borderline personality disorder (BPD) that often leads to destructive, impulsive behaviours against others. In line with recent findings in aggressive individuals, deficits in prefrontal amygdala coupling during emotional action control may account for these symptoms. METHODS: To study the neurobiological correlates of altered emotional action control in individuals with BPD, we asked medication-free, anger-prone, female patients with BPD and age- and intelligence-matched healthy women to take part in an approach-avoidance task while lying in an MRI scanner...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688871/altered-cortical-thickness-and-attentional-deficits-in-adolescent-girls-and-women-with-bulimia-nervosa
#15
Laura A Berner, Mihaela Stefan, Seonjoo Lee, Zhishun Wang, Kate Terranova, Evelyn Attia, Rachel Marsh
BACKGROUND: Frontostriatal and frontoparietal abnormalities likely contribute to deficits in control and attentional processes in individuals with bulimia nervosa and to the persistence of dysregulated eating across development. This study assessed these processes and cortical thickness in a large sample of adolescent girls and women with bulimia nervosa compared with healthy controls. METHODS: We collected anatomical MRI data from adolescent girls and women (ages 12-38 yr) with full or subthreshold bulimia nervosa and age-matched healthy controls who also completed the Conners Continuous Performance Test-II (CPT-II)...
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29688870/drug-coverage-in-canada-gaps-and-opportunities
#16
Fiona Clement, Katherine A Memedovich
No abstract text is available yet for this article.
May 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29481321/covert-dysphagia-and-recurrent-pneumonia-related-to-antipsychotic-treatment
#17
Jonathan T Stewart
No abstract text is available yet for this article.
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29481320/association-between-structural-and-functional-brain-alterations-in-drug-free-patients-with-schizophrenia-a-multimodal-meta-analysis
#18
Xin Gao, Wenjing Zhang, Li Yao, Yuan Xiao, Lu Liu, Jieke Liu, Siyi Li, Bo Tao, Chandan Shah, Qiyong Gong, John A Sweeney, Su Lui
BACKGROUND: Neuroimaging studies have shown both structural and functional abnormalities in patients with schizophrenia. Recently, studies have begun to explore the association between structural and functional grey matter abnormalities. By conducting a meta-analysis on morphometric and functional imaging studies of grey matter alterations in drug-free patients, the present study aims to examine the degree of overlap between brain regions with anatomic and functional changes in patients with schizophrenia...
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29481319/greater-body-mass-index-is-associated-with-reduced-frontal-cortical-volumes-among-adolescents-with-bipolar-disorder
#19
Alvi H Islam, Arron W S Metcalfe, Bradley J MacIntosh, Daphne J Korczak, Benjamin I Goldstein
BACKGROUND: Higher body mass index (BMI) and obesity is common among youth with bipolar disorder (BD) and is associated with greater psychiatric illness severity, including suicidality. Obesity has been associated with frontal, temporal and subcortical volumetric reductions in adults with BD. We examined the neurostructural correlates of BMI in adolescents early in their course of BD. METHODS: We processed T 1 -weighted images of adolescents with BD and psychiatrically healthy controls using FreeSurfer to derive a priori region of interest (ROI) volumes/cortical thickness for the frontal lobe (FL), prefrontal cortex (PFC) and orbitofrontal cortex (OFC) as well as volumes for the amygdala and hippocampus...
March 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29481318/arterial-stiffness-is-associated-with-depression-in-middle-aged-men-the-maastricht-study
#20
Veronica Onete, Ronald M Henry, Simone J S Sep, Annemarie Koster, Carla J van der Kallen, Pieter C Dagnelie, Nicolaas Schaper, Sebastian Köhler, Koen Reesink, Coen D A Stehouwer, Miranda T Schram
BACKGROUND: Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. METHODS: We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study...
March 2018: Journal of Psychiatry & Neuroscience: JPN
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