Marina Mihaljevic, Anisha Nagpal, Semra Etyemez, Zui Narita, Anna Ross, Rebecca Schaub, Nicola G Cascella, Jennifer M Coughlin, Gerald Nestadt, Frederik C Nucifora, Thomas W Sedlak, Vince D Calhoun, Andreia V Faria, Kun Yang, Akira Sawa
BACKGROUND: Recent reports have indicated that symptom exacerbation after a period of improvement, referred to as relapse, in early-stage psychosis could result in brain changes and poor disease outcomes. We hypothesized that substantial neuroimaging alterations may exist among patients who experience relapse in early-stage psychosis. METHODS: We studied patients with psychosis within 2 years after the first psychotic event and healthy controls. We divided patients into 2 groups, namely those who did not experience relapse between disease onset and the magnetic resonance imaging (MRI) scan (no-relapse group) and those who did experience relapse between these 2 timings (relapse group)...
2024: Journal of Psychiatry & Neuroscience: JPN