journal
MENU ▼
Read by QxMD icon Read
search

Journal of Psychiatry & Neuroscience: JPN

journal
https://www.readbyqxmd.com/read/30403026/lateral-orbitofrontal-dysfunction-in-the-sapap3-knockout-mouse-model-of-obsessive%C3%A2-compulsive-disorder
#1
Huimeng Lei, Juan Lai, Xiaohong Sun, Qunyuan Xu, Guoping Feng
Background: Obsessive–compulsive disorder (OCD) is a common psychiatric disorder that affects about 2% of the population, but the underlying neuropathophysiology of OCD is not well understood. Although increasing lines of evidence implicate dysfunction of the orbitofrontal cortex (OFC) in OCD, a detailed understanding of the functional alterations in different neuronal types in the OFC is still elusive. Methods: We investigated detailed activity pattern changes in putative pyramidal neurons and interneurons, as well as local field potential oscillations, in the lateral OFC underlying OCD-relevant phenotypes...
November 7, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30354038/brain-grey-matter-volume-alteration-in-adult-patients-with-bipolar-disorder-under-different-conditions-a-voxel-based-meta-analysis
#2
Xiuli Wang, Qiang Luo, Fangfang Tian, Bochao Cheng, Lihua Qiu, Song Wang, Manxi He, Hongming Wang, Mingjun Duan, Zhiyun Jia
Background: The literature on grey-matter volume alterations in bipolar disorder is heterogeneous in its findings. Methods: Using effect-size differential mapping, we conducted a meta-analysis of grey-matter volume alterations in patients with bipolar disorder compared with healthy controls. Results: We analyzed data from 50 studies that included 1843 patients with bipolar disorder and 2289 controls. Findings revealed lower grey-matter volumes in the bilateral superior frontal gyri, left anterior cingulate cortex and right insula in patients with bipolar disorder and in patients with bipolar disorder type I...
October 24, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30277457/apathy-alters-emotional-arousal-in-chronic-schizophrenia
#3
Thibaut Dondaine, Pierre Philippot, Jean-Marie Batail, Florence Le Jeune, Md PhD Paul Sauleau, Sophie Drapier, Marc Vérin, Md PhD Bruno Millet, Dominique Drapier, Gabriel Robert
BACKGROUND: Within the heterogeneity of schizophrenia, apathy constitutes an independent cluster of negative symptoms associated with poor outcomes. Attempts to identify an emotional deficit in patients who have schizophrenia with negative symptoms have yielded mixed results, and studies that focus on the relationship between apathy and emotional disorders are lacking. METHODS: We set out to remedy this shortcoming using a validated battery of film excerpts to induce positive and negative emotions in patients with chronic schizophrenia with ( n = 20) or without ( n = 20) apathy, and in controls ( n = 20) comparable for age, sex and socioeconomic status...
October 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30255837/gaba-levels-and-tspo-expression-in-people-at-clinical-high-risk-for-psychosis-and-healthy-volunteers-a-pet-mrs-study
#4
Tania Da Silva, Sina Hafizi, Pablo M Rusjan, Sylvain Houle, Alan A Wilson, Ivana Prce, Napapon Sailasuta, Romina Mizrahi
BACKGROUND: γ-Aminobutyric acidergic (GABAergic) dysfunction and immune activation have been implicated in the pathophysiology of schizophrenia. Preclinical evidence suggests that inflammation-related abnormalities may contribute to GABAergic alterations in the brain, but this has never been investigated in vivo in humans. In this multimodal imaging study, we quantified cerebral GABA plus macromolecule (GABA+) levels in antipsychotic-naive people at clinical high risk for psychosis and in healthy volunteers...
September 26, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30226714/lifetime-major-depression-and-grey-matter-volume
#5
Marie-Laure Ancelin, Carrière Isabelle, Artero Sylvaine, Maller Jerome, Meslin Chantal, Ritchie Karen, Ryan Joanne, Chaudieu Isabelle
Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how these alterations might be affected by age at onset or genetic vulnerability. This study examines whether lifetime episodes of MDD are associated with specific alterations in grey-matter volume, and whether those alterations vary according to sex or serotonin transporter-linked promoter region (5-HTTLPR) genotype (LL, SL or SS). Methods: We used structural MRI to acquire anatomic scans from 610 community-dwelling participants...
September 18, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30246686/cerebral-blood-flow-in-striatal-regions-is-associated-with-apathy-in-patients-with-schizophrenia
#6
Karoline Schneider, Lars Michels, Matthias N Hartmann-Riemer, Achim Burrer, Philippe N Tobler, Philipp Stämpfli, Matthias Kirschner, Erich Seifritz, Stefan Kaiser
BACKGROUND: Striatal dysfunction has been proposed as a pathomechanism for negative symptoms in schizophrenia. There is consensus that negative symptoms can be grouped into 2 dimensions: apathy and diminished expression. Recent studies suggest that different neural mechanisms underlie these dimensions, but the relationship between regional resting-state cerebral blood flow (rCBF) and negative symptom dimensions has not been investigated. METHODS: This study included 29 patients with schizophrenia and 20 healthy controls...
September 7, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30246688/psychoradiologic-abnormalities-of-white-matter-in-patients-with-bipolar-disorder-diffusion-tensor-imaging-studies-using-tract-based-spatial-statistics
#7
Cheng Yang, Xinyu Hu, Qiang Luo, Weihong Kuang, Su Lui, Xiaoqi Huang, Jing Dai, Manxi He, Graham J Kemp, John A Sweeney, Qiyong Gong
BACKGROUND: An increasing number of psychoradiology studies that use tract-based spatial statistics (TBSS) of diffusion tensor imaging have reported abnormalities of white matter in patients with bipolar disorder; however, robust conclusions have proven elusive, especially considering some important clinical and demographic factors. In the present study, we performed a quantitative meta-analysis of TBSS studies to elucidate the most consistent white-matter abnormalities in patients with bipolar disorder...
August 29, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30246687/affect-interpersonal-behaviour-and-interpersonal-perception-during-open-label-uncontrolled-paroxetine-treatment-of-people-with-social-anxiety-disorder-a-pilot-study
#8
Lance M Rappaport, Jennifer J Russell, Donald Hedeker, Gilbert Pinard, Pierre Bleau, Debbie S Moskowitz
BACKGROUND: Laboratory-based research with community samples has suggested changes in affective, behavioural and cognitive processes as possible explanations for the effects of serotonergic medications. Examining the effects of serotonergic medications using an ecological momentary measure (such as event-contingent recording) in the daily lives of people with social anxiety disorder would contribute to establishing the effects of these medications on affect, behaviour and one form of cognition: perception of others' behaviour...
August 29, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30375839/tic-related-obsessive%C3%A2-compulsive-disorder
#9
Tamara Pringsheim, John Piacentini
No abstract text is available yet for this article.
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30375838/peter-m-milner-1919%C3%A2-2018
#10
Norman M. White
No abstract text is available yet for this article.
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30375837/psychoradiological-patterns-of-small-world-properties-and-a-systematic-review-of-connectome-studies-of-patients-with-6-major-psychiatric-disorders
#11
REVIEW
Xueling Suo, Du Lei, Lei Li, Wenbin Li, Jing Dai, Song Wang, Manxi He, Hongyan Zhu, Graham J. Kemp, Qiyong Gong
Background: Brain connectome research based on graph theoretical analysis shows that small-world topological properties play an important role in the structural and functional alterations observed in patients with psychiatric disorders. However, the reported global topological alterations in small-world properties are controversial, are not consistently conceptualized according to agreed-upon criteria, and are not critically examined for consistent alterations in patients with each major psychiatric disorder...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30375835/affect-interpersonal-behaviour-and-interpersonal-perception-during-open-label-uncontrolled-paroxetine-treatment-of-people-with-social-anxiety-disorder-a-pilot-study
#12
Lance M. Rappaport, Jennifer J. Russell, Donald Hedeker, Gilbert Pinard, Pierre Bleau, Debbie S. Moskowitz
Background: Laboratory-based research with community samples has suggested changes in affective, behavioural and cognitive processes as possible explanations for the effects of serotonergic medications. Examining the effects of serotonergic medications using an ecological momentary measure (such as event-contingent recording) in the daily lives of people with social anxiety disorder would contribute to establishing the effects of these medications on affect, behaviour and one form of cognition: perception of others’ behaviour...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30375834/performance-monitoring-and-post-error-adjustments-in-adults-with-attention-deficit-hyperactivity-disorder-an-eeg-analysis
#13
Ann-Christine Ehlis, Saskia Deppermann, Andreas J. Fallgatter
Background: Recently, research into attention-deficit/hyperactivity disorder (ADHD) has focused increasingly on its neurobiological underpinnings, revealing (among other things) frontal lobe alterations. Specifically, action-monitoring deficits have been described, including impaired behavioural adjustments following errors. Our aim was to examine the neurophysiological background of post-error behavioural alterations in an adult ADHD sample for the first time, hypothesizing that people with ADHD would differ from controls in neurophysiological markers of cognitive preparation and stimulus processing, specifically following errors...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30372012/a-negative-association-between-brainstem-pontine-grey-matter-volume-well-being-and-resilience-in-healthy-twins
#14
Justine M. Gatt, Karen L.O. Burton, Kylie M. Routledge, Katrina L. Grasby, Mayuresh S. Korgaonkar, Stuart M. Grieve, Peter R. Schofield, Anthony W.F. Harris, C. Richard Clark, Leanne M. Williams
Background: Associations between well-being, resilience to trauma and the volume of grey-matter regions involved in affective processing (e.g., threat/reward circuits) are largely unexplored, as are the roles of shared genetic and environmental factors derived from multivariate twin modelling. Methods: This study presents, to our knowledge, the first exploration of well-being and volumes of grey-matter regions involved in affective processing using a region-of-interest, voxel-based approach in 263 healthy adult twins (60% monozygotic pairs, 61% females, mean age 39...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30371993/abnormal-protein-and-mrna-expression-of-inflammatory-cytokines-in-the-prefrontal-cortex-of-depressed-individuals-who-died-by-suicide
#15
Ghanshyam N. Pandey, Hooriyah S. Rizavi, Hui Zhang, Runa Bhaumik, Xinguo Ren
Background: Depression and stress are major risk factors for suicidal behaviour, and some studies show abnormalities of proinflammatory cytokines in the serum and cerebrospinal fluid (CSF) of depressed and suicidal patients. However, it is not clear if similar abnormalities of cytokines are present in the brain of suicidal and depressed patients. Methods: We therefore determined the mRNA (using realtime polymerase chain reaction) and protein (using enzyme-linked immunosorbent assay and Western Blot) expression levels of interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α, lymphotoxin A, lymphotoxin B, IL-8, IL-10 and IL-13 in the prefrontal cortex (PFC) obtained from 24 depressed individuals who died by suicide and 24 nonpsychiatric controls...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30371992/low-white-matter-integrity-between-the-left-thalamus-and-inferior-frontal-gyrus-in-patients-with-insomnia-disorder
#16
Jae Myeong Kang, Sung Woo Joo, Young-Don Son, Hyun Kim, Kwang-Pil Ko, Jung Sun Lee, Seung-Gul Kang
Background: Previous studies have reported functional and structural abnormalities in the thalamus and the pars triangularis of the inferior frontal gyrus in patients with insomnia disorder. However, no studies have been conducted on the white-matter tracts between these 2 brain regions. We aimed to compare the white-matter integrity and structure of the left thalamus–pars triangularis tracts between patients with insomnia and controls, and to characterize the relationship between white-matter integrity and clinical features in patients with insomnia...
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30371048/the-perils-of-being-too-stable-mood-regulation-in-bipolar-disorder
#17
EDITORIAL
Abigail Ortiz, Martin Alda
No abstract text is available yet for this article.
November 1, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30106360/head-motion-the-dirty-little-secret-of-neuroimaging-in-psychiatry
#18
Carolina Makowski, Martin Lepage, Alan C Evans
Psychiatry is at a crossroads when choosing final samples for analysis of neuroimaging data. Many patient populations exhibit significantly increased motion in the scanner compared with healthy controls, suggesting that more patients would need to be excluded to obtain a clean sample. However, this need is often overshadowed by the extensive amount of time and effort required to recruit these valuable and uncommon samples. This commentary sheds light on the impact of motion on imaging studies, drawing examples from psychiatric patient samples to better understand how head motion can confound interpretation of clinically oriented questions...
August 14, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30106359/er%C3%AE-agonist-alters-rna-splicing-factor-expression-and-has-a-longer-window-of-antidepressant-effectiveness-than-estradiol-after-long-term-ovariectomy
#19
Xu Hou, Samuel O Adeosun, Xueying Zhao, Rosanne Hill, Baoying Zheng, Reveena Reddy, Xiao Su, Jeffrey Meyer, Thomas Mosley, Jun Ming Wang
BACKGROUND: Estrogen therapy (ET), an effective treatment for perimenopausal depression, often fails to ameliorate symptoms when initiated late after the onset of menopause. Our previous work has suggested that alternative splicing of RNA might mediate these differential effects of ET. METHODS: Female Sprague-Dawley rats were treated with estradiol (E2) or vehicle 6 days (early ET) or 180 days (late ET) after ovariectomy (OVX). We investigated the differential expression of RNA splicing factors and tryptophan hydroxylase 2 (TPH2) protein using a customized RT2 Profiler PCR Array, reverse-transcription polymerase chain reaction, immunoprecipitation and behaviour changes in clinically relevant early and late ET...
August 14, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/30125247/white-matter-network-alterations-in-patients-with-depersonalization-derealization-disorder
#20
Anika Sierk, Judith K Daniels, Antje Manthey, Jelmer G Kok, Alexander Leemans, Michael Gaebler, Jan-Peter Lamke, Johann Kruschwitz, Henrik Walter
BACKGROUND: Depersonalization/derealization disorder (DPD) is a chronic and distressing condition characterized by detachment from oneself and/or the external world. Neuroimaging studies have associated DPD with structural and functional alterations in a variety of distinct brain regions. Such local neuronal changes might be mediated by altered interregional white matter connections. However, to our knowledge, no research on network characteristics in this patient population exists to date...
August 2018: Journal of Psychiatry & Neuroscience: JPN
journal
journal
30743
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"