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Journal of Investigational Allergology & Clinical Immunology

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https://www.readbyqxmd.com/read/30222115/quality-standards-for-allergen-immunotherapy-clinics-in-spain-consensus-document
#1
A Tabar, B Núñez Acevedo, J M Beitia Mazuecos, E Fernández Ibáñez, J Garde Garde, D Hernández Fernández de Rojas, V De Luque Piñana, P Ojeda Fernández, M Reaño Martos, F Rodríguez Fernández, A Roger Reig, J A Martínez, C Moreno Aguilar, C Vidal
BACKGROUND AND OBJECTIVE: The allergen immunotherapy clinics (AITC) in Spain are very different in terms of structure, organisation, resources and portfolio of services. Therefore, it is essential to unify treatment criteria and define quality standards for the most complex AITCs. Objective: To establish a series of recommendations that will make it possible to guarantee quality and safety in the administration of immunotherapy and to define the quality standards for the most complex AITCs...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30222114/neuropathic-pain-and-itch-mechanisms-underlying-allergic-conjunctivitis
#2
REVIEW
M Kuruvilla, J Kalangara, F Eun-Hyung Lee
OBJECTIVE: Among the symptom constellation that characterizes allergic conjunctivitis, many such as burning and stinging can be attributed to chronic neuropathic pain. There is accumulating data to support that these hallmark symptoms might be linked to the effects of allergen induced neuromodulation. This review will emphasize the key characteristics of neuropathic itch and pain in allergic conjunctivitis and its pathologic mechanisms. METHODS: A literature review was conducted using a PubMed search focusing on allergic conjunctivitis, allergic conjunctivitis, neurogenic inflammation, neuropathic itch, neuropathic pain...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30222113/obesity-and-asthma-key-clinical-questions
#3
REVIEW
F García-Rio, M J Alvarez-Puebla, I De Esteban, P Barranco, J M Olaguibel
Obesity is an asthma common comorbidity and is associated not only with its development, but also with a poorer control and higher severity of it. Recent prospective evidence supports the idea that body weight gain precedes the development of asthma, but the debate is far from over. The objective of this document is to conduct a systematic review of 3 clinical questions related to asthma and obesity: 1. Obesity and asthma: the chicken or the egg? Clinical insights from epidemiological and phenotypes studies...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30222112/heterogeneous-predisposing-factors-and-etiology-in-uvula-edema-patients
#4
J Barbarroja-Escudero, A Asúnsolo-Del-Barco, M J Sánchez-González, M Rodríguez-Rodríguez, M Alvarez-Mon
BACKGROUND AND OBJECTIVE: Edema of the uvula (EU) may appear in isolation or in association with other associated clinical manifestations such as urticaria, angioedema or anaphylaxis. EU may lead to upper airway obstruction, provoking obstructive respiratory distress and asphyxia. Objective: We sought to investigate the etiology of, and predisposing factors for, EU in a large population of patients referred to an outpatient clinic. METHODS: In this 3-year-follow-up cohort study, 171 patients presenting with EU were identified and classified as having isolated EU or non-isolated EU...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30222111/therapeutic-strategy-according-to-the-differing-patient-response-profiles-to-omalizumab-in-chronic-spontaneous-urticaria
#5
A M Giménez Arnau, A Valero Santiago, J Bartra Tomás, I Jáuregui Presa, M Labrador-Horrillo, F J Miquel Miquel, J Ortiz de Frutos, J Sastre, F J Silvestre Salvador, M Ferrer Puga
Chronic spontaneous urticaria (CSU) is a heterogeneous condition that can severely impact quality of life, which is why rapid disease control is essential. Symptomatic first-line treatment of CSU is the licensed dose of second-generation H1 antihistamines. For second-line treatment, this dose may be increased by up to four times. In patients who fail to respond to these higher doses of H1 antihistamines, treatment with omalizumab (up to 24 weeks) is recommended to achieve disease control. After this 24-week period, the patient response profile to omalizumab should be defined in order to identify refractory patients...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183661/limited-long-term-impact-of-insect-venom-immunotherapy-on-the-micro-rna-landscape-in-whole-blood
#6
P Karpinski, M Kahraman, N Ludwig, P Skiba, M Kosinska, M Rosiek-Biegus, E Królewicz, B Panaszek, M Nittner-Marszalska, N Blin, A Keller, E Meese, M Malgorzata Sasiadek
BACKGROUND AND OBJECTIVE: To perform a genome-wide characterization of changes of microRNA (miRNA) expression in the course of VIT (venom immunotherapy). METHODS: miRNA was isolated form in the whole-blood of 13 allergic patients and 14 controls, who showed no allergic reaction upon stings by honeybees and wasps. We analyzed 2549 different miRNAs from whole blood of these patients prior to VIT and 12 months after the start of the VIT. Differential expression results obtained on microarray platform were confirmed by quantitative real -time PCR (qRT-PCR)...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183660/hymenoptera-venom-allergy-management-of-children-and-adults-in-clinical-practice
#7
M B Bilò, V Pravettoni, D Bignardi, P Bonadonna, M Mauro, E Novembre, O Quercia, M Cilia, G Cortellini, M T Costantino, L Cremonte, F L Rizzini, L Macchia, F Marengo, F Murzilli, V Patella, F Reccardini, L Ricciardi, E Ridolo, A Romano, E Savi, D Schiavino, M Severino, E A Pastorello
Hymenoptera venom allergy is an epidemiologically underestimated condition representing an important cause of morbidity worldwide. Preventing future allergic reactions in patients who have developed a systemic reaction is based on the correct management of emergency followed by a correct diagnosis, prescription of adrenaline autoinjectors and, where indicated, specific venom immunotherapy (VIT). Some epidemiological studies highlight the poor knowledge of this disease and the frequent inadequacy of its management...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183659/elevated-exhaled-nitric-oxide-in-adolescents-relates-to-incident-allergic-symptoms-a-prospective-cohort-study
#8
P Kalm-Stephens, L Nordvall, C Janson, Å Neuman, A Malinovschi, K Alving
BACKGROUND: The fraction of exhaled nitric oxide (FeNO) is a marker of type-2 inflammation in the airways and elevated FeNO may precede development of allergic disease. The aim of the present study was to investigate the association between elevated FeNO and the development of allergic symptoms. METHODS: A total of 959 adolescents from a general population answered, together with their parents, a standardized questionnaire, performed lung function and FeNO measurements at a baseline visit...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183658/is-quantitative-sige-serology-suitable-to-distinguish-between-silent-sensitization-and-allergic-rhinitis-to-d-pteronyssinus
#9
D Gellrich, C Meßmer, S Becker, M Gröger
BACKGROUND AND OBJECTIVE: Recently, an increasing number of studies focus on the debate whether provocation tests might be replaceable by specific IgE serology in patients sensitized to airborne allergens. Objective: Our study aimed to analyse the concordance between a nasal provocation test with Dermatophagoides pteronyssinus and specific IgE measurements in real-life data. MATERIAL AND METHODS: In 223 patients with proven sensitization to Dermatophagoides pteronyssinus, the concordance between the result of the provocation test and the IgE titer against several house dust mite components and extracts was retrospectively analysed...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183657/accurate-of-the-diagnosis-of-allergy-reactions-at-the-emergency-department
#10
J Lacombe-Barrios, F Gómez, N Perez, E Barrionuevo, I Doña, D Fernández Tahia, C Mayorga, M J Torres, E Moreno, B Gador, M Salas
BACKGROUND: Suspicion of an acute allergic reaction is a common reason for attending Emergency Departments (ED). However, little work has been performed comparing the initial diagnosis made in the ED of patients with suspected allergic reaction, with the definitive diagnosis made subsequently in the allergy department (AD). Objective: Compare details of the initial diagnoses given in the ED relating to allergy with the final diagnoses performed in the AD. METHODS: Patients attending the ED of two hospitals with suspected allergic reactions were prospectively enrolled based on keywords...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183656/false-positive-results-of-serological-tests-for-allergy-in-alcoholics
#11
L Alvela-Suarez, J Campos, I Carballo, J Gomez-Rial, M Lombardero, A Linneberg, C Vidal, A Gonzalez-Quintela
BACKGROUND: Alcohol consumption is associated with enhanced Th2 immune responses. Aim: To investigate the frequency of false-positive serological tests of allergy in alcoholics. METHODS: A total of 138 alcoholic patients consecutively admitted to hospital underwent a panel of allergy tests that included serum total IgE, a multiallergen IgE test (UniCAP Phadiatop), and skin prick tests to relevant aeroallergens in the area, which were considered the standard reference for atopy...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30183655/autoimmune-aspects-of-kawasaki-disease
#12
REVIEW
Y Sakurai
Kawasaki disease (KD) is classified as a medium-sized vasculitis of systemic vasculitis syndrome characterized by hypercytokinemia. Although the etiology of KD remains unidentified, epidemiological features point to the role of infection and genetic predisposition. Recent studies revealed endothelial damage and resultant thrombin generation, as well as B-cell activation during the acute phase of KD. Several anti-endothelial cell autoantibodies (AECAs) have been identified in KD patients. Taken together with the recently developed concept of immunothrombosis, a potential pathogenic mechanism for KD emerges...
September 5, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30059012/wheat-food-allergy-in-adults-has-a-favorable-prognosis
#13
J Scibilia, C M Rossi, L M Losappio, C Mirone, L Farioli, V Pravettoni, E A Pastorello
BACKGROUND AND OBJECTIVE: Wheat ingestion can lead to different disorders such as IgE-mediated food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA), associated with impaired quality of life and significant morbidity. Allergy to wheat is relatively benign in children, however its natural history in adults is still unknown. Objective: We evaluated the natural history of wheat hypersensitivity in atopic patients with adult-onset wheat- allergy assessed by placebo-controlled-challenge...
July 30, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30059011/eosinophils-old-players-in-a-new-game
#14
REVIEW
B Sastre, J M Rodrigo-Muñoz, D A Garcia-Sanchez, J A Cañas, V Del Pozo
Eosinophils are terminal polymorphonuclear cells originated from bone marrow with an important number of cytoplasmic granules, some of them are exosomes, which contain multiple molecules such as specific eosinophilic proteins, cytokines, chemokines, enzymes, and lipid mediators that contribute to effector role of these cells. Moreover, they present a large number of receptors that allow them interact with multiple cellular types. Eosinophils play an important role in defence against infestations and they are a key element in asthma and allergic diseases...
July 30, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30004024/basic-skin-care-and-topical-therapies-for-atopic-dermatitis-beyond-essential-approaches
#15
REVIEW
A Sala-Cunill, M Lazaro, L Herráez, M D Quiñones, M Moro-Moro, I Sanchez
Atopic dermatitis (AD) is a recurrent and chronic skin disease characterised by dysfunction in the epithelial barrier, skin inflammation and immune dysregulation with changes in the skin microbiota and colonisation of Staphylococcus aureus being common. For this reason, the therapeutic approach to AD is complex and should be directed at restoring skin barrier function, reducing dehydration, maintaining acidic pH and avoiding superinfection and exposure to possible allergens. No curative treatment for AD currently exists...
July 13, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29957591/prospective-open-label-study-of-48-week-subcutaneous-administration-of-mepolizumab-in-japanese-patients-with-severe-eosinophilic-asthma
#16
M Kurosawa, E Sutoh
BACKGROUND: Long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated by large-scale double-blinded placebo control studies. However, a prospective open-label study of a long-term subcutaneous administration of mepolizumab in Japanese patients with severe eosinophilic asthma has not been reported. METHODS: This study was a prospective, 48-week, open-label trial in 32 Japanese patients with severe eosinophilic asthma who received subcutaneous administration of 100 mg mepolizumab every 4 weeks...
June 29, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29956666/prevalence-of-drugs-as-triggers-of-exacerbations-in-chronic-urticaria
#17
J Sánchez Jorge, A Sánchez, R Cardona
BACKGROUND AND OBJECTIVE: Many patients with chronic spontaneous urticaria (CSU) identify different drugs as triggers of their symptoms and often make restrictions without enough information. Objective: To estimate the clinical impact of the drugs most frequently reported as suspects of CSU exacerbations by patients. METHODS: All subjects were questioned about their clinical history of urticaria and drug reactions. Drug challenge tests were performed on each patient with the suspicious drugs...
June 29, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29956665/independent-factors-contributing-to-the-daytime-and-nighttime-asthmatic-cough-refractory-to-inhaled-corticosteroids
#18
Y Kanemitsu, H Matsumoto, T Oguma, T Nagasaki, I Ito, Y Izuhara, T Tajiri, T Iwata, M Mishima, A Niimi
BACKGROUND: Cough is a common feature of asthma, which is often resistant to inhaled corticosteroids (ICS). The pathophysiology involved in such refractoriness may be different between the daytime and nighttime asthmatic cough. We sought to identify factors contributing to the daytime and nighttime asthmatic cough refractory to ICS treatment. METHODS: Sixty-seven patients with asthma solely or predominantly presenting with chronic cough were prospectively enrolled from April 2012 to December 2014...
June 29, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30073972/testing-for-fecal-calprotectin-in-food-protein-induced-enterocolitis-syndrome
#19
S Khan
No abstract text is available yet for this article.
August 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/30073971/eosinophilic-granulomatosis-with-polyangiitis-and-cardiac-involvement-a-case-report
#20
G Adami, M Caminati, G Senna, A Fassio, M Schiappoli, L Idolazzi, O Viapiana
No abstract text is available yet for this article.
August 2018: Journal of Investigational Allergology & Clinical Immunology
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