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Fetal Diagnosis and Therapy

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https://www.readbyqxmd.com/read/28813702/tocolysis-for-in-utero-surgery-atosiban-performs-distinctly-better-than-magnesium-sulfate
#1
Nicole Ochsenbein-Kölble, Franziska Krähenmann, Margret Hüsler, Martin Meuli, Ueli Moehrlen, Lucca Mazzone, Peter Biro, Roland Zimmermann
INTRODUCTION: To compare tocolysis with magnesium sulfate versus atosiban regarding the occurrence of short-term preterm labor and maternal side effects during and after open fetal myelomeningocele (MMC) repair. MATERIAL AND METHODS: A prospective nonrandomized cohort study was performed including 30 fetal MMC cases. The first 15 cases (group 1) received magnesium sulfate according to the MOMS protocol. In the following 15 cases (group 2), magnesium sulfate was substituted by atosiban...
August 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28813701/uterine-cervical-length-measurement-to-reduce-length-of-stay-in-patients-admitted-for-threatened-preterm-labor-a-randomized-trial
#2
Montse Palacio, Javier Caradeux, Miriam Sánchez, Teresa Cobo, Francesc Figueras, Oriol Coll, Eduard Gratacós, Vicenç Cararach
OBJECTIVE: To study whether knowledge of cervical length (CL) is useful in reducing the length of hospital stay in women admitted because of threatened preterm labor. METHODS: We performed a single-center, parallel, randomized trial at the Hospital Clínic of Barcelona. Inclusion criteria were single pregnancy, gestational age (GA) between 24+0 and 35+6 weeks, Bishop score <6, no parturition within 24-48 h after admission, and no clinical signs of chorioamnionitis, vaginal bleeding, or nonreassuring fetal status...
August 17, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28803252/two-dimensional-echocardiography-estimates-of-fetal-ventricular-mass-throughout-gestation
#3
Christina Y L Aye, Adam James Lewandowski, Eric O Ohuma, Ross Upton, Alice Packham, Yvonne Kenworthy, Fenella Roseman, Tess Norris, Malid Molloholli, Sikolia Wanyonyi, Aris T Papageorghiou, Paul Leeson
BACKGROUND: Two-dimensional (2D) ultrasound quality has improved in recent years. Quantification of cardiac dimensions is important to screen and monitor certain fetal conditions. We assessed the feasibility and reproducibility of fetal ventricular measures using 2D echocardiography, reported normal ranges in our cohort, and compared estimates to other modalities. METHODS: Mass and end-diastolic volume were estimated by manual contouring in the four-chamber view using TomTec Image Arena 4...
August 12, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28796996/call-for-caution-neonatal-portal-vein-thrombosis-following-enbucrilate-embolization-of-placental-chorioangioma
#4
Hian Yan Voon, Rafaie Amin, Juan Loong Kok, Kia Sing Tan
We illustrate a case of giant placental chorioangioma presenting at 20 weeks of gestation. Subsequent monitoring revealed enlargement of the lesion, associated with fetal anemia and cardiac failure, prompting in utero intervention. Amnioreduction followed by percutaneous embolization of the tumour with enbucrilate:Lipiodol Ultra-Fluid™ at a dilution of 1:5 was successfully performed. No repeat intervention or additional supportive measures were required throughout pregnancy and the baby was delivered at 36 weeks of gestation, following spontaneous labour...
August 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28796999/preterm-prelabor-rupture-of-membranes-between-34-and-37-weeks-a-point-of-care-test-of-vaginal-fluid-interleukin-6-concentrations-for-a-noninvasive-detection-of-intra-amniotic-inflammation
#5
Marian Kacerovsky, Ivana Musilova, Tomas Bestvina, Martin Stepan, Teresa Cobo, Bo Jacobsson
OBJECTIVE: The aim of this study was to investigate whether a previously reported vaginal fluid point-of-care interleukin (IL)-6 cut-off value of 2,500 pg/mL can be used for the identification intra-amniotic inflammation in women with preterm prelabor rupture of membranes (PPROM) between 34 and 37 weeks. MATERIAL AND METHODS: A prospective cohort study was conducted in women with singleton gestation complicated by PPROM between 34 + 0 and 36 + 6 weeks. Vaginal fluid was successfully obtained in 118 women from the posterior vaginal fornix via aspiration using a sterile urine sample tube with a suction tip...
August 10, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28787718/antenatal-treatment-with-intravenous-immunoglobulin-to-prevent-gestational-alloimmune-liver-disease-comparative-effectiveness-of-14-week-versus-18-week-initiation
#6
Peter F Whitington, Susan Kelly, Sarah A Taylor, Sara Nóbrega, Richard A Schreiber, Etienne M Sokal, Judith U Hibbard
BACKGROUND: Antenatal therapy with high-dose intravenous immunoglobulin (IVIG) may prevent gestational alloimmune liver disease (GALD). OBJECTIVE: The objective of this study was to determine the effectiveness of this approach in a large cohort of women at risk for poor pregnancy outcome due to GALD. METHODS: Women with a history of affected offspring were provided antenatal IVIG treatment and data were acquired prospectively from 1997 to 2015...
August 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28768252/amniotic-fluid-concentrations-of-glial-fibrillary-acidic-protein-do-not-correlate-with-prenatal-metrics-in-fetuses-with-myelomeningocele
#7
Aimee G Kim, Enrico Danzer, Julie S Moldenhauer, Nahla Khalek, Lauren E McClain, Lindsay N Waqar, Holly L Hedrick, Mark P Johnson, N Scott Adzick, William H Peranteau, Alan W Flake
INTRODUCTION: We investigated the correlation of amniotic fluid (AF) concentrations of glial fibrillary acidic protein (GFAP) with prenatal features of myelomeningocele (MMC) and neurodevelopmental outcome after fetal MMC (fMMC) surgery. MATERIALS AND METHODS: AF was collected during fMMC surgery between December 2012 and November 2015. AF-GFAP concentration was determined by ELISA. Retrospective chart review identified the characteristics of the defect. Data regarding delivery and 1-year neurodevelopmental outcome was collected from The Children's Hospital of Philadelphia fMMC Registry...
July 29, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28746929/excessive-maternal-orange-intake-a-reversible-etiology-of-fetal-premature-ductus-arteriosus-constriction-a-case-report
#8
Shaimaa Rakha
Ductus arteriosus (DA) is a crucial element in the fetal circulation. Therefore, premature constriction of DA during the third trimester can have hazardous complications such as right ventricular dysfunction, fetal heart failure, hydrops, and even in utero demise. Normally, premature constriction is prevented by a balance between prostaglandin E2 and fetal oxygenation. Thus, drugs with antiprostaglandin effects are well-known causes for fetal DA constriction. A similar effect was discovered in eating polyphenol-rich food...
July 27, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28746928/diagnostic-performance-of-cerebroplacental-ratio-thresholds-at-term-for-prediction-of-low-birthweight-and-adverse-intrapartum-and-neonatal-outcomes-in-a-term-low-risk-population
#9
Larissa N Bligh, Amal Al Solai, Ristan M Greer, Sailesh Kumar
OBJECTIVES: To investigate the screening performance and best threshold centile (5th vs. 10th) of the cerebroplacental ratio (CPR) in low-risk, term pregnancies to predict low birthweight and adverse intrapartum and neonatal outcomes in a term, low-risk population. METHODS: This was a blinded, prospective, cross-sectional study of low-risk singleton pregnancies at term. Women attended fortnightly from 36 weeks for CPR and estimated fetal weight assessment. Intrapartum and neonatal outcomes were recorded...
July 27, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28743114/cervical-alpha-actinin-4-is-upregulated-in-women-with-threatened-preterm-labor-and-microbial-invasion-of-the-amniotic-cavity
#10
Teresa Cobo, Montse Palacio, Maribel Grande, Ana B Sánchez-García, Josep M Estanyol, Marta López, Jordi Bosch, Cristina Martí, Eduard Gratacós
OBJECTIVE: To characterize the proteome profile of women with threatened preterm labor (PTL) below 34;0 weeks with and without microbial invasion of the amniotic cavity (MIAC) using mass spectrometry in the amniotic fluid (AF) and Western blot analysis in the cervical mucus and the vaginal fluid. SUBJECTS AND METHODS: In the discovery phase, a case-control study including 8 women with MIAC and 7 without matched for gestational age at sampling was performed. Proteomic profile characterization was done using the LTQ VELOS Orbitrap mass spectrometer in the AF...
July 26, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28728157/3-d-volume-assessment-of-the-corpus-callosum-and-cerebellar-vermis-using-various-volume-acquisition-and-post-processing-protocols
#11
Veronika Frisova, Martina Srutova, Jon Hyett
OBJECTIVES: To determine which 3-D techniques are most effective for "real time" prenatal ultrasound assessment of the corpus callosum and cerebellar vermis. METHODS: A prospective study involving 100 consecutive normal singleton pregnancies attending routine anomaly scan at 19-23 weeks' gestation. Midsagittal structures of the fetal brain were assessed using six different methods of 3-D image acquisition and three post-processing techniques. The quality of the resulting images were then assessed and scored by a second operator...
July 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28728156/predicting-the-risk-to-develop-preeclampsia-in-the-first-trimester-combining-promoter-variant-98a-c-of-lgals13-placental-protein-13-black-ethnicity-previous-preeclampsia-obesity-and-maternal-age
#12
Liora Madar-Shapiro, Ido Karady, Alla Trahtenherts, Argryo Syngelaki, Ranjit Akolekar, Liona Poon, Ruth Cohen, Adi Sharabi-Nov, Berthold Huppertz, Marei Sammar, Kata Juhasz, Nandor Gabor Than, Zoltan Papp, Roberto Romero, Kypros H Nicolaides, Hamutal Meiri
BACKGROUND: LGALS13 (placental protein 13 [PP13]) promoter DNA polymorphisms was evaluated in predicting preeclampsia (PE), given PP13's effects on hypotension, angiogenesis, and immune tolerance. METHODS: First-trimester plasma samples (49 term and 18 intermediate) of PE cases matched with 196 controls were collected from King's College Hospital, London, repository. Cell-free DNA was extracted and the LGALS13 exons were sequenced after PCR amplification. Expression of LGALS13 promoter reporter constructs was determined in BeWo trophoblast-like cells with luciferase assays...
July 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28728149/higher-rates-of-operative-delivery-and-maternal-and-neonatal-complications-in-persistent-occiput-posterior-position-with-a-large-head-circumference-a-retrospective-cohort-study
#13
Oren Yagel, Sarah M Cohen, Michal Lipschuetz, Tali Bdolah-Abram, Hagai Amsalem, Doron Kabiri, Simcha Yagel
INTRODUCTION: We investigated whether large head circumference (HC) combined with persistent occiput posterior (OP) position is associated with higher rates of operative delivery and obstetric and neonatal complications than OP deliveries without large HC or in occiput anterior (OA) position. MATERIALS AND METHODS: Term singleton deliveries in our centers from January 2010 to December 2014, delivered in cephalic OA (n = 41,038) or OP position (n = 1,740), were assessed...
July 21, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28719896/update-on-the-diagnosis-and-prognosis-of-preeclampsia-with-the-aid-of-the-sflt-1-plgf-ratio-in-singleton-pregnancies
#14
Ignacio Herraiz, Elisa Llurba, Stefan Verlohren, Alberto Galindo
Preeclampsia (PE) is involved in a group of obstetrical conditions closely related by the presence of placental dysfunction (PD), which also includes intrauterine growth restriction and placental abruption. The timely and accurate recognition and management of PE are often challenging because diagnostic criteria are still based on nonspecific signs and symptoms and because common severity criteria correlate poorly with adverse maternal and fetal outcomes. The discovery of the role of angiogenesis-related factors - soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) - in the underlying pathophysiology of PD has marked an important step for improving its early diagnosis and prognosis assessment before gestational week 34...
July 19, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28715818/first-trimester-combined-multimarker-prospective-study-for-the-detection-of-pregnancies-at-a-high-risk-of-developing-preeclampsia-using-the-fetal-medicine-foundation-algorithm
#15
Meriem Guizani, Joseph Valsamis, Vivien Dutemeyer, Xin Kang, Vera Ceccoti, Joe Khalife, Silvia F Duiella, Frederic Blavier, Alessandra Faraca, Teresa Cos, Jacques C Jani
OBJECTIVE: To evaluate the Fetal Medicine Foundation (FMF) algorithm prospectively at 11-13 weeks' gestation in the prediction of preeclampsia (PE). METHODS: Single-center prospective screening study for PE of singleton pregnancies at 11-13 weeks. The FMF algorithm takes into account maternal characteristics and biomarkers. Detection rate (DR) for a 10% false-positive rate (FPR) for delivery with preterm and term PE was estimated. RESULTS: Between January 2011 and December 2013, of 3,239 patients available for final analysis, 36 (1...
July 18, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28715806/real-time-volume-contrast-imaging-in-the-a-plane-with-a-four-dimensional-electronic-probe-facilitates-the-evaluation-of-fetal-extremities-in-midtrimester-sonograms
#16
Federica Bellussi, Giuliana Simonazzi, Ginevra Salsi, Francesca Guasina, Gianluigi Pilu
OBJECTIVE: To evaluate the efficiency of real-time volume contrast imaging in the A plane (VCI-A) of fetal extremities, compared with conventional two-dimensional ultrasound (2D). METHODS: This was a randomized controlled trial of 100 patients undergoing midtrimester sonography. The fetal limbs were imaged with either 2D or VCI-A with a four-dimensional (4D) electronic probe. Time required for the examination, number of images stored, and quality of the documentation were compared...
July 18, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28715807/amniotic-fluid-angiogenic-and-inflammatory-factor-profiling-in-foetal-down-syndrome
#17
Monika Zbucka-Kretowska, Karol Charkiewicz, Jan Czerniecki, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski
OBJECTIVES: Angiogenic factors are proteins that can potentially be related to certain foetal chromosomal abnormalities. The goal of this study was to determine the concentrations of 60 angiogenic factors in the amniotic fluid of women carrying foetuses with Down syndrome (DS). METHODS: After analysis of the karyotyping results, for the purpose of this study, we chose 12 women with foetal DS. For the control group, we selected 12 healthy patients with uncomplicated pregnancies (15-18 weeks of gestation) who delivered healthy newborns at term...
July 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28719900/second-to-third-trimester-longitudinal-growth-assessment-for-the-prediction-of-largeness-for-gestational-age-and-macrosomia-in-an-unselected-population
#18
Javier Caradeux, Elisenda Eixarch, Edurne Mazarico, Tri Rahmat Basuki, Eduard Gratacós, Francesc Figueras
BACKGROUND: Prenatal detection of excessive growth remains inaccurate. Most strategies rely on a single cross-sectional evaluation of fetal size during the third trimester. OBJECTIVES: To compare second- to third-trimester longitudinal growth assessment with cross-sectional evaluation at the third trimester in the prediction of largeness for gestational age (LGA) and macrosomia. METHODS: A cohort of 2,696 unselected singleton pregnancies scanned at 21 ± 2 and 32 ± 2 weeks was created...
July 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28700992/natural-history-of-fetal-lower-urinary-tract-obstruction-with-normal-amniotic-fluid-volume-at-initial-diagnosis
#19
Mark P Johnson, Enrico Danzer, Jamie Koh, William Polzin, Chris Harman, Richard O'Shaughnessy, Richard Brown, Michael V Zaretsky
OBJECTIVE: The aim of this study was to define the natural history of lower urinary tract obstruction (LUTO) with normal midgestational amniotic fluid volumes. MATERIALS AND METHODS: We performed a retrospective review of 32 consecutive patients with LUTO with normal midgestational amniotic fluid volume followed at 11 North American Fetal Therapy Network (NAFTNet) centers from August 2007 to May 2012. Normal amniotic fluid volume was defined as an amniotic fluid index (AFI) of ≥9 cm...
July 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28697499/perinatal-outcomes-of-non-primary-maternal-cytomegalovirus-infection-a-15-year-experience
#20
Giuliana Simonazzi, Alessandra Curti, Francesca Cervi, Liliana Gabrielli, Margherita Contoli, Maria Grazia Capretti, Nicola Rizzo, Brunella Guerra, Antonio Farina, Tiziana Lazzarotto
OBJECTIVE: To evaluate perinatal outcomes in case of non-primary maternal cytomegalovirus (CMV) infection. METHODS: We performed a retrospective cohort study of pregnant women with active CMV infection referred to our unit over a 15-year period (January 2000 to December 2014). Non-primary infection was diagnosed on the basis of the results of confirmatory serological and virological tests (avidity test, immunoblotting, real-time PCR-DNA). The vertical transmission rate and the percentage of symptomatic congenital infection were determined in this group of patients...
July 12, 2017: Fetal Diagnosis and Therapy
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