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Fetal Diagnosis and Therapy

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https://www.readbyqxmd.com/read/29045943/reference-ranges-for-fetal-atrioventricular-and-ventriculoatrial-time-intervals-and-their-ratios-during-normal-pregnancy
#1
Beatrice Mosimann, Georgios Arampatzis, Sofia Amylidi-Mohr, Anice Bessire, Marialuigia Spinelli, Petros Koumoutsakos, Daniel Surbek, Luigi Raio
BACKGROUND: The diagnostic assessment of fetal arrhythmias relies on the measurements of atrioventricular (AV) and ventriculoatrial (VA) time intervals. Pulsed Doppler over in- and outflow of the left ventricle and tissue Doppler imaging are well-described methods, while Doppler measurements between the left brachiocephalic vein and the aortic arch are less investigated. The aim of this study was to compare these methods of measurement, to find influencing factors on AV and VA times and their ratio, and to create reference ranges...
October 19, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29020672/early-environmental-enrichment-enhances-abnormal-brain-connectivity-in-a-rabbit-model-of-intrauterine-growth-restriction
#2
Miriam Illa, Verónica Brito, Laura Pla, Elisenda Eixarch, Ariadna Arbat-Plana, Dafnis Batallé, Emma Muñoz-Moreno, Fatima Crispi, Esther Udina, Francesc Figueras, Silvia Ginés, Eduard Gratacós
INTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. MATERIALS AND METHODS: IUGR was surgically induced in one horn, whereas the contralateral one produced the controls...
October 12, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29017154/screening-performance-of-placental-growth-factor-for-the-prediction-of-low-birth-weight-and-adverse-intrapartum-and-neonatal-outcomes-in-a-term-low-risk-population
#3
Larissa N Bligh, Ristan M Greer, Sailesh Kumar
INTRODUCTION: Fetuses who fail to reach their genetic growth potential are thought to have sub-optimal placental function. Low placental growth factor (PlGF) levels have been shown to be predictive of placentally mediated conditions, such as pre-eclampsia or fetal growth restriction. We investigated the screening performance of PlGF for the prediction of low birth weight (<10th centile for gestation) and adverse intrapartum and neonatal outcomes in apparently low-risk term pregnancies...
October 11, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28977797/evaluation-of-magnetic-resonance-imaging-safety-and-imaging-issues-associated-with-the-occlusion-balloon-used-during-fetoscopic-endoluminal-tracheal-occlusion
#4
Teresa Victoria, Ann M Johnson, N Scott Adzick, Holly L Hedrick, Frank G Shellock
INTRODUCTION: Congenital diaphragmatic hernias can be successfully treated by fetoscopic tracheal occlusion (FETO), a minimally invasive procedure that may improve postnatal survival. The endoluminal balloon utilized for FETO contains a metallic component that may pose possible risks for the fetus and mother related to the use of magnetic resonance imaging (MRI). The objective of this study is to evaluate MRI-related imaging and safety issues (magnetic field interactions, heating, and artifacts) for the occlusion balloon used in FETO...
October 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28977787/parental-origin-of-the-retained-x-chromosome-in-monosomy-x-miscarriages-and-ongoing-pregnancies
#5
Maribel Grande, Iosifina Stergiotou, Montse Pauta, Borja Marquès, Cèlia Badenas, Anna Soler, Yuval Yaron, Antoni Borrell
OBJECTIVE: To assess the distribution of the parental origin of the retained X chromosome in monosomy X, either in miscarriages or in ongoing pregnancies. METHOD: The parental origin of the X chromosome was determined in monosomy X pregnancies, either miscarriages or ongoing pregnancies. Microsatellite marker patterns were compared between maternal and fetal samples by quantitative fluorescence polymerase chain reaction. Distributions of maternally and paternally derived X chromosome were assessed in miscarriages and in ongoing pregnancies using two-tailed Fisher exact test...
October 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28950258/automation-of-the-fetal-right-myocardial-performance-index-to-optimise-repeatability
#6
Viviena Leung, Hagai Avnet, Amanda Henry, Jingjing Wang, Stephen Redmond, Alec W Welsh
OBJECTIVES: To compare the repeatability and degree of absolute agreement of an automated fetal right myocardial performance index (MPI) algorithm with manual measurements along with the impact of MPI observer experience on these two aspects. METHODS: Prospective cross-sectional study of 65 uncomplicated singleton pregnancies from 22 to 39 weeks' gestation. Image analysis of double-waveform right MPI measurements was conducted first with a MATLAB automated MPI software and then independently by an experienced and an inexperienced observer...
September 27, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28950252/prognostic-features-and-long-term-outcome-in-patients-with-isolated-fetal-ventriculomegaly
#7
Alice Winkler, Sandra Tölle, Giancarlo Natalucci, Barbara Plecko, Josef Wisser
OBJECTIVE: In order to provide aid for prenatal counseling in fetal isolated ventriculomegaly (IVM) on ultrasound, we recorded the latest long-term clinical and imaging outcomes of children with a mean age of 7.2 years (range 2.1-14.6). METHODS: In 72 fetuses with IVM, diagnosed between 1999 and 2011, the measurement quality of atrial diameter was reviewed in the axial plane. We assessed the association of characteristics of IVM with outcome parameters in the cohort and in subgroups...
September 27, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28926826/a-low-cerebroplacental-ratio-at-20-24-weeks-of-gestation-can-predict-reduced-fetal-size-later-in-pregnancy-or-at-birth
#8
Edgar Hernandez-Andrade, Eli Maymon, Offer Erez, Homam Saker, Suchaya Luewan, Maynor Garcia, Hyunyoung Ahn, Adi L Tarca, Bogdan Done, Steven J Korzeniewski, Sonia S Hassan, Roberto Romero
AIM: To determine whether Doppler evaluation at 20-24 weeks of gestation can predict reduced fetal size later in pregnancy or at birth. METHODS: Fetal biometry and Doppler velocimetry were performed in 2,986 women with a singleton pregnancy at 20-24 weeks of gestation. Predictive performances of the umbilical artery pulsatility index (UA-PI) or the mean uterine artery pulsatility index (UtA-PI) >95th percentile, middle cerebral artery pulsatility index, or cerebroplacental ratio (CPR) <5th percentile for early small for gestational age (SGA; <34 weeks of gestation), late SGA (≥34 weeks of gestation), or SGA at birth (birthweight <10th percentile) were analyzed...
September 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28926825/fetal-growth-and-placental-growth-factor-umbilical-cord-blood-levels
#9
Zoe A Broere-Brown, Sarah Schalekamp-Timmermans, Vincent W V Jaddoe, Eric A P Steegers
OBJECTIVE: We assessed whether umbilical cord blood placental growth factor (PlGF) levels at delivery are associated with fetal growth. METHODS: From a prospective population-based cohort study we included 3,461 live singleton births. Fetal growth was assessed by birth weight, fetal growth pattern, and fetal growth restriction (FGR; decrease in growth between the second trimester and birth of ≥40 percentiles). In all analyses the highest PlGF multiple of the median (MoM) quintile was used as the reference category...
September 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28918426/aortic-isthmus-flow-recording-predicts-the-outcome-of-the-recipient-twin-after-laser-coagulation-in-twin-twin-transfusion-syndrome
#10
France Leduc, Amélie Delabaere, Roxanne Gendron, Florent Fuchs, Sandrine Wavrant, Marie-Josée Raboisson, Jean-Claude Fouron, François Audibert
INTRODUCTION: The objective was to assess the prognostic value of the systolic flow through the aortic isthmus in monochorionic pregnancies complicated by twin-twin transfusion syndrome (TTTS) treated by placental laser ablation. MATERIAL AND METHODS: Fetal echocardiography and outcome data of 105 cases of TTTS treated by laser photocoagulation of placental anastomoses were reviewed. Hemodynamic parameters were collected before and after treatment. The isthmic systolic index (ISI) was calculated as the peak systolic velocity/systolic nadir ratio...
September 16, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28910784/fetal-surgery-for-myelomeningocele-a-systematic-review-and-meta-analysis-of-outcomes-in-fetoscopic-versus-open-repair
#11
Sandra K Kabagambe, Guy W Jensen, Yue Julia Chen, Melissa A Vanover, Diana L Farmer
BACKGROUND/OBJECTIVES: The Management of Myelomeningocele (MMC) Study (MOMS) showed that prenatal repair of MMC resulted in improved neurological outcomes but was associated with high rates of obstetrical complications. This study compares outcomes of open and fetoscopic MMC repair. DATA SOURCES: PubMed and Embase studies reporting outcomes of fetal MMC repair published since the completion of the MOMS. RESULTS: We analyzed 11 studies and found no difference in mortality or the rate of shunt placement for hydrocephalus...
September 15, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28898891/new-insights-into-the-natural-history-of-congenital-zika-virus-syndrome
#12
María Guadalupe Lovagnini Frutos, José Héctor Ochoa, María Gabriela Barbás, Héctor Dante Lucchini, Martín Moya, Gustavo Malinger
We describe the prenatal evolution of the brain findings in a patient with proved Zika virus infection at 8 weeks of gestation showing the very early appearance at 17 weeks of ventriculomegaly and signs of brain parenchymal involvement without microcephaly. The involvement of the brain becomes more evident at 22 and 27 weeks with the apparition of calcifications and microcephaly. Interestingly, the postnatal findings failed to show significant worsening when compared to these prenatal findings.
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28898888/outcome-of-bronchopulmonary-sequestration-with-massive-pleural-effusion-after-intrafetal-vascular-laser-ablation
#13
Ingo Gottschalk, Brigitte Strizek, Michael R Mallmann, Andreas Müller, Annegret Geipel, Ulrich Gembruch, Philipp Klaritsch, Bence Csapo, Christoph Berg
OBJECTIVE: To assess the outcome of 12 fetuses with bronchopulmonary sequestration (BPS) and massive pleural effusion after intrafetal vascular laser ablation (VLA). METHODS: All fetuses with BPS and massive pleural effusion that were treated with intrafetal VLA during a 5-year period (2012-2016) were reviewed for safety, intrauterine course, and postnatal outcome. RESULTS: In the study period, 12 fetuses with BPS were treated with VLA. In 7 (58...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28898871/placental-component-and-pregnancy-outcome-in-singleton-versus-twin-pregnancies-complicated-by-preeclampsia
#14
Eran Weiner, Ohad Feldstein, Letizia Schreiber, Ehud Grinstein, Elad Barber, Ann Dekalo, Jacob Bar, Michal Kovo
OBJECTIVE: To compare placental histopathological lesions and pregnancy outcomes in singleton and twin pregnancies complicated by preeclampsia (PE). METHODS: Maternal characteristics, neonatal outcomes, and placental histopathology reports of pregnancies complicated by PE between January 2008 and October 2016 were reviewed. Results were compared between singletons (singleton group) and dichorionic-diamniotic twins (twin group). Placental lesions were classified into maternal and fetal vascular supply lesions...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28898865/automatic-measurement-of-fetal-brain-development-from-magnetic-resonance-imaging-new-reference-data
#15
Daphna Link, Michael B Braginsky, Leo Joskowicz, Liat Ben Sira, Shaul Harel, Ariel Many, Ricardo Tarrasch, Gustavo Malinger, Moran Artzi, Cassandra Kapoor, Elka Miller, Dafna Ben Bashat
BACKGROUND: Accurate fetal brain volume estimation is of paramount importance in evaluating fetal development. The aim of this study was to develop an automatic method for fetal brain segmentation from magnetic resonance imaging (MRI) data, and to create for the first time a normal volumetric growth chart based on a large cohort. SUBJECTS AND METHODS: A semi-automatic segmentation method based on Seeded Region Growing algorithm was developed and applied to MRI data of 199 typically developed fetuses between 18 and 37 weeks' gestation...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28889126/chromosomal-microarray-analysis-in-fetuses-with-growth-restriction-and-normal-karyotype-a-systematic-review-and-meta-analysis
#16
Antoni Borrell, Maribel Grande, Montse Pauta, Laia Rodriguez-Revenga, Francesc Figueras
OBJECTIVE: To perform a systematic review of the literature and a meta-analysis to estimate the incremental yield of chromosomal microarray analysis (CMA) over karyotyping in fetal growth restriction (FGR). METHODS: This was a systematic review conducted in accordance with the PRISMA criteria. All articles identified in PubMed, Ovid Medline, and ISI Web of Knowledge (Web of Science) from January 2009 to November 2016 describing pathogenic copy number variants (CNVs) in fetuses with growth restriction were included...
September 9, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28873375/non-invasive-prenatal-testing-for-sex-chromosome-aneuploidy-in-routine-clinical-practice
#17
Louise Kornman, Ricardo Palma-Dias, Debbie Nisbet, Fergus Scott, Melody Menezes, Fabricio da Silva Costa, Andrew McLennan
OBJECTIVES: To assess the accuracy of non-invasive prenatal testing (NIPT) for sex chromosome aneuploidy (SCA) in routine clinical practice and to review counselling and sonographic issues arising in SCA cases. METHODS: Three specialist Australian obstetric ultrasound and prenatal diagnosis practices offering NIPT after 10 weeks' gestation participated in this study. NIPT was reported for chromosomes 21, 18, 13, X, and Y. RESULTS: NIPT screening was performed in 5,267 singleton pregnancies...
September 6, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28873371/modified-hysterotomy-closure-technique-for-open-fetal-surgery
#18
Michael V Zaretsky, Kenneth W Liechty, Henry L Galan, Nicholas J Behrendt, Shane Reeves, Ahmed I Marwan, Corbett Wilkinson, Michael Handler, Megan Lagueux, Timothy M Crombleholme
OBJECTIVE: We reviewed our experience with open fetal surgical myelomeningocele repair to assess the efficacy of a new modification of the hysterotomy closure technique regarding hysterotomy complication rates at the time of cesarean delivery. METHODS: A modification of the standard hysterotomy closure was performed on all patients undergoing prenatal myelomeningocele repair. The closure consisted of an interrupted full-thickness #0 polydioxanone (PDS) retention suture as well as a running #0 PDS suture to re-approximate the myometrial edges, and the modification was a third imbricating layer resulting in serosal-to-serosal apposition...
September 6, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28873370/understanding-the-parent-perspective-on-prenatal-consultation-for-fetuses-with-congenital-anomalies
#19
Loren Berman, Caitlyn Costanzo, Susan Smola, Alison Taggi-Pinto, Francois L Luks
INTRODUCTION: An increasing number of congenital anomalies are diagnosed prenatally. Understanding the implications of these diagnoses on the life of their child is critical for parents, and the surgical consultation is often the primary venue for this education. Little is known about the parent perspective on prenatal consultation. METHODS: Parents undergoing prenatal consultation were identified and in-depth interviews were conducted to explore the following: understanding of the diagnosis, preparedness for postnatal course, and suggestions for improvement...
September 6, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28869935/fetal-aneuploidy-a-comparison-of-dichorionic-twins-and-monochorionic-twins
#20
Xiaomei Shi, Lin Li, Xuan Huang, Baojiang Chen, Yi Zhou, Qun Fang
OBJECTIVE: To assess the clinical characteristics of fetal aneuploidy between dichorionic twins (DCT) and monochorionic twins (MCT) undergoing invasive prenatal diagnosis. METHODS: Twin fetuses undergoing invasive prenatal diagnosis were enrolled in this study. All twin fetuses were classified into 2 groups according to chorionicity. The rates of fetal aneuploidy in different groups were compared. RESULT: This study included 1,714 fetuses (857 sets of twin pairs); among them, 1,190 were DCT and 524 were MCT...
September 5, 2017: Fetal Diagnosis and Therapy
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