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Annals of Hematology

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https://www.readbyqxmd.com/read/28920169/diagnostic-value-of-strem-1-il-8-pct-and-crp-in-febrile-neutropenia-after-autologous-stem-cell-transplantation
#1
C S Michel, D Teschner, E M Wagner, M Theobald, Markus P Radsak
Infections and infectious complications are the major cause of morbidity and mortality in febrile neutropenic patients after autologous stem cell transplantation. Laboratory biomarkers are helpful for early identification of critically ill patients and optimal therapy management. Several studies in adult non-neutropenic patients proposed sTREM-1 as a superior biomarker for identification of septic patients as well as a predictor for survival in these patients compared with procalcitonin (PCT), C-reactive protein (CRP), or interleukin-8 (IL-8)...
September 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28905189/bortezomib-and-low-dose-dexamethasone-with-or-without-continuous-low-dose-oral-cyclophosphamide-for-primary-refractory-or-relapsed-multiple-myeloma-a-randomized-phase-iii-study
#2
Martin Kropff, Martin Vogel, Guido Bisping, Rudolf Schlag, Rudolf Weide, Wolfgang Knauf, Heinrich Fiechtner, Georgi Kojouharoff, Stephan Kremers, Wolfgang E Berdel
This phase III, open-label, randomized, controlled study aimed to evaluate the benefit of adding continuous low-dose oral cyclophosphamide to bortezomib-dexamethasone in patients with primary relapsed/refractory multiple myeloma. Patients were randomized 1:1 to receive up to eight 3-week cycles of bortezomib (1.3 mg/m(2)) and dexamethasone (20 mg; VD; n = 48) or bortezomib-dexamethasone plus oral cyclophosphamide (50 mg; VCD; n = 48). Median time to progression (primary endpoint) was slightly longer in the VD versus VCD group (12...
September 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28889238/langerhans-cell-histiocytosis-and-erdheim-chester-disease-overlap-syndrome-with-bone-marrow-involvement-and-type-2-diabetes-mellitus
#3
LETTER
Miao Chen, Cheng Ding, Tao Lu, Na Niu, Bing Han
No abstract text is available yet for this article.
September 9, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28887661/widening-the-spectrum-of-deletions-and-molecular-mechanisms-underlying-alpha-thalassemia
#4
José Ferrão, Marisa Silva, Lúcia Gonçalves, Susana Gomes, Pedro Loureiro, Andreia Coelho, Armandina Miranda, Filomena Seuanes, Ana Batalha Reis, Francisca Pina, Raquel Maia, Paula Kjöllerström, Estela Monteiro, João F Lacerda, João Lavinha, João Gonçalves, Paula Faustino
Inherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, multiplex ligation-dependent probe amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the sub-telomeric region of the short arm of chromosome 16, possibly explaining the α-thalassemia/HbH disease phenotype in ten patients. We have found six different deletions, in heterozygosity, ranging from approximately 3...
September 8, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28884221/evaluation-of-the-greek-tranqol-a-novel-questionnaire-for-measuring-quality-of-life-in-transfusion-dependent-thalassemia-patients
#5
Philippos Klonizakis, Robert Klaassen, Nikolaos Sousos, Aris Liakos, Apostolos Tsapas, Efthymia Vlachaki
The aim of our study was to evaluate the Greek version of the transfusion-dependent quality of life (TranQol) questionnaire and report our experience of using this novel disease-specific quality of life (QoL) measure in patients with transfusion-dependent thalassemia (TDT). The TranQol and SF-36v2 questionnaires were administered to 94 adult TDT patients with a mean age of 32.1 years (SD = 7, range = 19-58), recruited from the Adult Thalassemia Unit of Hippokration General Hospital of Thessaloniki, Greece...
September 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28879595/preemptive-plerixafor-injection-added-to-pegfilgrastim-after-chemotherapy-in-non-hodgkin-lymphoma-patients-mobilizing-poorly
#6
A Partanen, J Valtola, A Ropponen, K Vasala, K Penttilä, L Ågren, M Pyörälä, T Nousiainen, T Selander, P Mäntymaa, J Pelkonen, V Varmavuo, E Jantunen
Filgrastim is usually combined with chemotherapy to mobilize hematopoietic progenitor cells in non-Hodgkin lymphoma (NHL) patients. Limited information is available on the efficacy of a preemptive plerixafor (PLER) injection in poor mobilizers after chemotherapy and pegfilgrastim. In this prospective study, 72 patients with NHL received chemotherapy plus pegfilgrastim, and 25 hard-to-mobilize patients received also PLER. The usefulness and efficacy of our previously developed algorithm for PLER use in pegfilgrastim-containing mobilization regimen were evaluated as well as the graft cellular composition, hematological recovery, and outcome after autologous stem cell transplantation (auto-SCT) according to the PLER use...
September 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28879554/congenital-dyserythropoietic-anemia-type-ii-mimicking-hereditary-spherocytosis-in-indian-patient-with-sec23b-y462c-mutations
#7
LETTER
Prabhakar Kedar, Vaishali Parmar, Rati Devendra, Vinod Gupta, Prashant Warang, Manisha Madkaikar
No abstract text is available yet for this article.
September 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28879531/pd1-blockade-with-low-dose-nivolumab-in-nk-t-cell-lymphoma-failing-l-asparaginase-efficacy-and-safety
#8
LETTER
Thomas S Y Chan, Jamilla Li, Florence Loong, Pek-Lan Khong, Eric Tse, Yok-Lam Kwong
No abstract text is available yet for this article.
September 6, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28879427/relapsed-subcutaneous-panniculitis-like-t-cell-lymphoma-role-of-haploidentical-hematopoietic-stem-cell-transplant
#9
LETTER
Bhagirathbhai Dholaria, Raj J Patel, Jason C Sluzevich, Sikander Ailawadhi, Vivek Roy
No abstract text is available yet for this article.
September 6, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28875368/relative-abundance-of-%C3%AE-thalassemia-related-mutations-in-southern-china-correlates-with-geographical-coordinates
#10
LETTER
Yingying Zhao, Shenming Guan, Wenhui Song, Yongping Li, Lizhen Ling, Yu Wang, Xinshu Li, Lili Qin, Haijing Yu, Huanming Yang, Jian Wang, Jinlong Yang, Jin Liu, Le Cheng
No abstract text is available yet for this article.
September 5, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28875336/progression-of-liver-fibrosis-can-be-controlled-by-adequate-chelation-in-transfusion-dependent-thalassemia-tdt
#11
D Maira, E Cassinerio, A Marcon, M Mancarella, M Fraquelli, P Pedrotti, M D Cappellini
A substantial proportion of patients with transfusion-dependent beta-thalassemia major suffer from chronic liver disease. Iron overload resulting from repeated transfusions and HCV infection has been implicated in the development of liver fibrosis. Hepatic siderosis and fibrosis were assessed in 99 transfusion-dependent thalassemia (TDT) patients using transient elastography (TE) and liver iron concentration (LIC) assessed by T2*MRI at baseline and after 4 years. Data were analyzed retrospectively. At baseline, the overall mean liver stiffness measurement (LSM) was 7...
September 5, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28871325/high-level-of-soluble-interleukin-2-receptor-in-serum-predicts-treatment-resistance-and-poor-progression-free-survival-in-multiple-myeloma
#12
Liang Wang, Jing-Hua Wang, Wen-Jian Liu, Wei-da Wang, Hua Wang, Xiao-Qin Chen, Qi-Rong Geng, Yue Lu, Zhong-Jun Xia
The IL-2/IL-2 receptor (IL-2R) system plays a central role in maintaining normal T cell immunity, and its disturbance is associated with several hematologic disorders. Studies have found in several types of lymphoma that abnormal amounts of soluble IL-2R (sIL-2R) may result in imbalance of the IL-2/IL-2R system and hence of the T cell immunoregulation. Whether the level of sIL-2R in blood could predict treatment outcomes or not needs to be investigated in multiple myeloma (MM) patients. The level of sIL-2R in serum was measured using enzyme-linked immunosorbent assay (ELISA) in 81 patients with newly diagnosed MM...
September 5, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28868592/early-stage-primary-cranial-vault-lymphoma-in-a-50-year-old-man-presenting-as-only-sclerosis-and-mimicking-osteoma
#13
LETTER
Sun Hwa Lee, Seong Jong Yun
No abstract text is available yet for this article.
September 3, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28861599/interleukin-6-in-idiopathic-multicentric-castleman-s-disease-after-long-term-tocilizumab
#14
LETTER
Mitsuhiro Akiyama, Hidekata Yasuoka, Tsutomu Takeuchi
No abstract text is available yet for this article.
September 1, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28856437/diagnosis-and-empirical-treatment-of-fever-of-unknown-origin-fuo-in-adult-neutropenic-patients-guidelines-of-the-infectious-diseases-working-party-agiho-of-the-german-society-of-hematology-and-medical-oncology-dgho
#15
REVIEW
W J Heinz, D Buchheidt, M Christopeit, M von Lilienfeld-Toal, O A Cornely, H Einsele, M Karthaus, H Link, R Mahlberg, S Neumann, H Ostermann, O Penack, M Ruhnke, M Sandherr, X Schiel, J J Vehreschild, F Weissinger, G Maschmeyer
Fever may be the only clinical symptom at the onset of infection in neutropenic cancer patients undergoing myelosuppressive chemotherapy. A prompt and evidence-based diagnostic and therapeutic approach is mandatory. A systematic search of current literature was conducted, including only full papers and excluding allogeneic hematopoietic stem cell transplant recipients. Recommendations for diagnosis and therapy were developed by an expert panel and approved after plenary discussion by the AGIHO. Randomized clinical trials were mainly available for therapeutic decisions, and new diagnostic procedures have been introduced into clinical practice in the past decade...
August 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28852831/uterine-intravascular-lymphoma-as-a-cause-of-fever-of-unknown-origin
#16
Jérôme Hadjadj, Hubert Nielly, Eve Piekarski, Wendy Cuccuini, Bénedicte Deau-Fischer, Muriel Hourseau, Khadija Benali, Claire Fieschi, Marc Aletti, Thomas Papo, Eric Oksenhendler, Lionel Galicier, David Boutboul
Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant (18)FDG uptake on (18)FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases...
August 29, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28849334/cytogenetic-evidence-for-the-clonal-hematopoietic-cell-origin-of-alveolar-macrophages-in-myelodysplastic-syndrome-associated-pulmonary-alveolar-proteinosis
#17
LETTER
Yuya Nagai, Chiyuki Kishimori, Miho Nakagawa, Ikkoh Yasuda, Gen Honjo, Hitoshi Ohno
No abstract text is available yet for this article.
August 28, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28842789/a-comparison-of-therapeutic-dosages-of-decitabine-in-treating-myelodysplastic-syndrome-a-meta-analysis
#18
Bo Yang, Ruili Yu, Lili Cai, Xiaohua Chi, Cui Liu, Lei Yang, Xueyan Wang, Peifeng He, Xuechun Lu
Decitabine is used to treat myelodysplastic syndrome (MDS). This meta-analysis evaluated the efficacy and safety of different dosing regimens of decitabine in treating intermediate and/or high-risk MDS. Medline, Cochrane, EMBASE, and Google Scholar databases were searched up to October 23, 2015. Randomized controlled trials, prospective, cohort, and case series studies were included. Fifteen studies were included with a total of 1378 patients. The decitabine 100 mg/m(2)/course dosing regimen had a greater overall response rate than the 60-75 mg/m(2)/course (51 vs...
August 25, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28842748/pd-l1-expression-correlates-with-vegf-and-microvessel-density-in-patients-with-uniformly-treated-classical-hodgkin-lymphoma
#19
Young Wha Koh, Jae-Ho Han, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh
Recent studies have reported the associations between programmed death-ligand 1 (PD-L1) or PD-L2/PD-1 pathways and pro-angiogenic genes including hypoxia-inducible factors (HIFs) and vascular endothelial growth factor (VEGF) in several malignancies. However, no study has examined the relationship or prognostic implication of PD-L1, PD-L2, PD-1, VEGF expression, and microvessel density (MVD) in classical Hodgkin lymphoma (cHL) patients. Diagnostic tissues from 109 patients with doxorubicin, bleomycin, vinblastine, and dacarbazine-treated cHL were evaluated retrospectively by immunohistochemical analysis for PD-L1, PD-L2, PD-1, VEGF expression, and for CD31 expression as a measure of MVD...
August 25, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28840298/therapy-related-acute-myeloid-leukemia-with-inv-16-after-successful-therapy-for-de-novo-acute-myeloid-leukemia-with-t-8-21
#20
LETTER
Haigang Shao, Qian Yang, Chunxiao Wu, Jiannong Cen, Suning Chen, Jinlan Pan
No abstract text is available yet for this article.
August 24, 2017: Annals of Hematology
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