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Annals of Hematology

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https://www.readbyqxmd.com/read/28536895/autologous-stem-cell-transplantation-asct-in-patients-with-mantle-cell-lymphoma-a-retrospective-study-of-the-spanish-lymphoma-group-geltamo
#1
A García-Noblejas, J Cannata-Ortiz, E Conde, E González Barca, N Gutiérrez, R Rojas, M J Vidal, M J Ramírez, A Jiménez-Ubieto, J C García-Ruiz, J M Sancho, A López, P Ríos Rull, S Novelli, C Albo, G Debén, A López-Guillermo, C Nicolás, S González de Villambrosia, S Mercadal, A Martín García-Sancho, R Arranz
Guidelines recommend autologous stem cell transplantation (ASCT) consolidation in first complete or partial response after regimens including rituximab (R) and high-dose AraC (HDAC), but its use beyond that response is questioned. We present a retrospective analysis of 268 patients with MCL who received ASCT. With a median follow-up for survival patients of 54 months, progression-free survival and overall survival for the whole series were 38 and 74 months, respectively, and for patients transplanted in first CR 49 and 97 months, respectively...
May 24, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28534184/evaluation-of-cardiovascular-ischemic-event-rates-in-dasatinib-treated-patients-using-standardized-incidence-ratios
#2
Giuseppe Saglio, Philipp le Coutre, Jorge Cortes, Jiří Mayer, Philip Rowlings, François-Xavier Mahon, Glenn Kroog, Kyna Gooden, Milayna Subar, Neil P Shah
With high survival rates for chronic myeloid leukemia (CML) patients treated with BCR-ABL1 tyrosine kinase inhibitors (TKIs), emerging consequences, such as arterial ischemic events, require consideration when evaluating treatment options. Cardiovascular ischemic event incidence in clinical trials was evaluated in 2712 dasatinib-treated patients with Philadelphia chromosome-positive (Ph+) leukemias from 11 first- and second-line trials (pooled), newly diagnosed CML patients treated with dasatinib or imatinib (DASISION), and prostate cancer patients treated with dasatinib or placebo plus docetaxel/prednisone (READY)...
May 22, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28526957/cytomorphology-review-of-100-newly-diagnosed-lower-risk-mds-patients-in-the-european-leukemianet-mds-eumds-registry-reveals-a-high-inter-observer-concordance
#3
Louise de Swart, Alex Smith, Marius MacKenzie, Argiris Symeonidis, Judith Neukirchen, Dana Mikulenková, Teresa Vallespí, Gina Zini, Malgorzata Paszkowska-Kowalewska, Anton Kruger, Leonie Saft, Pierre Fenaux, David Bowen, Eva Hellström-Lindberg, Jaroslav Čermák, Reinhard Stauder, Aurelia Tatic, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Jackie Droste, Nicole Blijlevens, Theo de Witte, Ulrich Germing
The European LeukemiaNet MDS (EUMDS) registry is collecting data of myelodysplastic syndrome (MDS) patients belonging to the IPSS low or intermediate-1 category, newly diagnosed by local cytologists. The diagnosis of MDS can be challenging, and some data report inter-observer variability with regard to the assessment of the MDS subtype. In order to ensure that correct diagnoses were made by the participating centres, blood and bone marrow slides of 10% of the first 1000 patients were reviewed by an 11-person panel of cytomorphologists...
May 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28526956/erratum-to-role-of-complexity-of-variant-philadelphia-chromosome-in-chronic-myeloid-leukemia-in-the-era-of-tyrosine-kinase-inhibitor-therapy
#4
Zimu Gong, Lan Zheng, Zhenya Tang, Zi Chen, Wei Wang, Shi Bai, Guilin Tang, L Jeffrey Medeiros, Shimin Hu
No abstract text is available yet for this article.
May 20, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28526955/hbq-india-hba1-c-193g-c-hematological-profiles-and-unique-ce-hplc-findings-of-potential-diagnostic-utility-in-65-cases
#5
LETTER
Sudha Sharma, Prashant Sharma, Reena Das, Sanjeev Chhabra, Jasbir Kaur Hira
No abstract text is available yet for this article.
May 19, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28516193/co-mutated-calr-and-mpl-driver-genes-in-a-patient-with-myeloproliferative-neoplasm
#6
LETTER
Mónica Bernal, Pilar Jiménez, Jose Puerta, Francisco Ruíz-Cabello, Manuel Jurado
No abstract text is available yet for this article.
May 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28508935/successful-treatment-of-calcineurin-inhibitor-induced-pain-syndrome-with-acute-graft-versus-host-disease-by-switching-calcineurin-inhibitors-followed-by-pregabalin
#7
LETTER
Mitsumasa Watanabe, Yusuke Koba, Akira Tamekane
No abstract text is available yet for this article.
May 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28508934/xanthomatous-macrophages-in-bone-marrow-biopsies-systemic-manifestation-of-mycobacterioses
#8
LETTER
Cristiano Claudino Oliveira, Lígia Niéro-Melo, Maria Aparecida Custódio Domingues
No abstract text is available yet for this article.
May 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28508176/the-prognostic-role-of-cd68-and-foxp3-expression-in-patients-with-primary-central-nervous-system-lymphoma
#9
Hyunsoo Cho, Se Hoon Kim, Soo-Jeong Kim, Jong Hee Chang, Woo Ick Yang, Chang-Ok Suh, June-Won Cheong, Yu Ri Kim, Jung Yeon Lee, Ji Eun Jang, Yundeok Kim, Yoo Hong Min, Jin Seok Kim
The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively...
May 15, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28508175/comparison-of-r-cvp-with-r-chop-for-very-elderly-patients-aged-80-or-over-with-diffuse-large-b-cell-lymphoma
#10
LETTER
Hideki Arakaki, Tomonori Nakazato, Yuki Osada, Chisako Ito, Yoshinobu Aisa, Takehiko Mori
No abstract text is available yet for this article.
May 15, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28502031/vitamin-d-and-plasma-cell-dyscrasias-reviewing-the-significance
#11
REVIEW
Nicholas Burwick
Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder and precursor disease to multiple myeloma and other related cancers. While MGUS is considered a benign disorder, with a low risk of disease progression, patients have altered bone microarchitecture and an increased risk of bone fracture. In addition, alterations in immune function are regularly found to correlate with disease activity. Vitamin D, an important hormone for bone and immune health, is commonly deficient in multiple myeloma patients...
May 13, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28502030/co-occurrence-of-type-i-calr-and-two-mpl-mutations-in-patient-with-primary-myelofibrosis
#12
LETTER
Hammad Tashkandi, Erika M Moore, Benjamin Tomlinson, Teresa Goebel, Navid Sadri
No abstract text is available yet for this article.
May 13, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28500427/a-japanese-infant-with-systemic-juvenile-xanthogranuloma-mimicking-severe-microangiopathy
#13
LETTER
Hiroshi Yagasaki, Noriko Watanabe, Maiko Hirai, Katsuyoshi Shimozawa, Hideo Mugishima, Shori Takahashi
No abstract text is available yet for this article.
May 12, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28497365/clinical-utility-of-soluble-interleukin-2-receptor-in-hemophagocytic-syndromes-a-systematic-scoping-review
#14
REVIEW
Molly Lin, Sujin Park, Anna Hayden, Dean Giustini, Martina Trinkaus, Morris Pudek, Andre Mattman, Marion Schneider, Luke Y C Chen
The serum-soluble interleukin-2 receptor (sIL-2r) level is considered an important diagnostic test and disease marker in hemophagocytic syndromes/hemophagocytic lymphohistiocytosis (HPS/HLH). However, this cytokine receptor is rarely measured in clinical practice and has been excluded from recent diagnostic/classification criteria such as the HScore and macrophage activation syndrome (MAS) 16. We performed a systematic scoping review of 64 articles (1975-2016) examining the clinical utility of sIL-2r in HPS/HLH...
May 12, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28474144/a-retrospective-study-evaluating-the-impact-of-infectious-complications-during-azacitidine-treatment
#15
Anna Schuck, Marie-Christine Goette, Judith Neukirchen, Andrea Kuendgen, Norbert Gattermann, Thomas Schroeder, Guido Kobbe, Ulrich Germing, Rainer Haas
Azacitidine has become an available therapy for high-risk myelodysplastic syndromes. Infectious complications (IC) may impede the success of therapy. Since most patients are managed in an outpatient setting, often with low level of clinical and microbiological documentation, the impact of IC remains unclear. We retrospectively evaluated the clinical course of 77 patients with MDS treated with azacitidine between 2004 and 2015 (median age 69 years). Clinical workup included severity and type of IC, days in the hospital and with antimicrobial therapy, response to azacitidine, and overall survival (OS)...
May 4, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28466264/peripheral-blood-lymphocyte-monocyte-ratio-following-completion-of-first-line-therapy-predicts-early-relapse-in-patients-with-diffuse-large-b-cell-lymphoma-methodological-issues-to-avoid-misinterpretation
#16
LETTER
https://www.readbyqxmd.com/read/28466263/pyogenic-brain-abscesses-treated-with-antibiotics-in-a-patient-with-hemophagocytic-lymphohistiocytosis-on-hlh-94-protocol
#17
LETTER
Rochelle Castillo, Aadhar Patil, Victoria Forbes
No abstract text is available yet for this article.
May 2, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28456851/ruxolitinib-reduces-jak2-p-v617f-allele-burden-in-patients-with-polycythemia-vera-enrolled-in-the-response-study
#18
Alessandro Maria Vannucchi, Srdan Verstovsek, Paola Guglielmelli, Martin Griesshammer, Timothy C Burn, Ahmad Naim, Dilan Paranagama, Mahtab Marker, Brian Gadbaw, Jean-Jacques Kiladjian
In patients with polycythemia vera (PV), an elevated JAK2 p.V617F allele burden is associated with indicators of more severe disease (e.g., leukocytosis, splenomegaly, and increased thrombosis risk); however, correlations between allele burden reductions and clinical benefit in patients with PV have not been extensively evaluated in a randomized trial. This exploratory analysis from the multicenter, open-label, phase 3 Randomized Study of Efficacy and Safety in Polycythemia Vera With JAK Inhibitor INCB018424 Versus Best Supportive Care trial evaluated the long-term effect of ruxolitinib treatment on JAK2 p...
April 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28456850/influence-of-body-mass-index-on-survival-in-indolent-and-mantle-cell-lymphomas-analysis-of-the-stil-nhl1-trial
#19
Lukas Weiss, Thomas Melchardt, Alexander Egle, Georg Hopfinger, Hubert Hackl, Richard Greil, Juergen Barth, Mathias Rummel
Obesity is a well-known risk factor for the development of cancer, but its influence on the course of disease is still controversial. We investigated the influence of body mass index (BMI) on overall survival (OS) in 502 patients with indolent non-Hodgkin's lymphoma or mantle cell lymphoma in a subgroup analysis of the StiL (Study Group Indolent Lymphomas) NHL1 trial. We defined a cut-off of 22.55 kg/m(2) by ROC calculation and Youden Index analysis and stratified patients into "low BMI" and "high BMI". Five-year OS was significantly longer in the high BMI group (82...
April 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28451805/role-of-bone-marrow-biopsy-in-staging-of-patients-with-classical-hodgkin-s-lymphoma-undergoing-positron-emission-tomography-computed-tomography
#20
B Puccini, L Nassi, C Minoia, S Volpetti, R Ciancia, P C Riccomagno, A Di Rocco, A Mulè, C Toldo, M C Sassone, R Guariglia, C Filì, E Finolezzi, S Falorio, S Zanon, A Furlan, G Doa, F Zaja
Several studies suggested that staging bone marrow biopsy (BMB) could be omitted in patients with classical Hodgkin's lymphoma (cHL) when a positron emission tomography/computed tomography (PET/CT) is performed at baseline.To address the concordance between BMB and PET/CT in the detection of bone marrow involvement (BMI) and the BMB role in determining the Ann Arbor stage, we retrospectively collected data on 1244 consecutive patients with cHL diagnosed from January 2007 to December 2013. One thousand eighty-five patients who had undergone both BMB and PET/CT were analyzed, comparing the Ann Arbor stage assessed with PET/CT only to that resulting from PET/CT combined with BMB...
April 28, 2017: Annals of Hematology
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