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Psychiatric Genetics

Elisa Dalla Vecchia, Niall Mortimer, Viola S Palladino, Sarah Kittel-Schneider, Klaus-Peter Lesch, Andreas Reif, Annette Schenck, William H J Norton
Animal and cellular models are essential tools for all areas of biological research including neuroscience. Model systems can also be used to investigate the pathophysiology of psychiatric disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). In this review, we provide a summary of animal and cellular models for three genes linked to ADHD and ASD in human patients - CNTNAP2, ADGRL3, and PARK2. We also highlight the strengths and weaknesses of each model system...
November 9, 2018: Psychiatric Genetics
Xinjun Li, Cecilia Sjöstedt, Jan Sundquist, Bengt Zöller, Kristina Sundquist
AIMS: In the era of genome-wide association studies, familial risks are used to estimate disease heritability and success in gene identification. We wanted to estimate associations of 42 autoimmune diseases with attention-deficit hyperactivity disorder (ADHD) between individuals and family members. PARTICIPANTS AND METHODS: The availability of a Multigeneration Register in Sweden provides reliable access to family data that covers the last century. An open cohort design of the diseases in individual and family members was obtained through linkage to the Hospital Discharge Register...
November 6, 2018: Psychiatric Genetics
Antonia Eirich, Teresa Biermann, Christian P Müller, Johannes Kornhuber, Beben Benyamin, Gary K Hulse, Dieter B Wildenauer, Sibylle G Schwab
OBJECTIVES: Susceptibility to heroin dependence is strongly influenced by genetic factors with heritability estimates as high as 0.7. A number of genes, as well as environmental factors, are likely to contribute to its etiology. Not all individuals who have ever tried heroin at some stage during their lifetime become dependent on heroin. It has been suggested that genetic factors might be more important in the transition stage to heroin dependence rather than in environmental exposures and experimenting with heroin...
September 26, 2018: Psychiatric Genetics
Jiaxin Hu, Yan Bi, Lei Shi, Fei Xu, Fan Yuan, Weibo Niu, Decheng Ren, Zhenming Guo, Fengping Yang, Lin He, Guang He
No abstract text is available yet for this article.
December 2018: Psychiatric Genetics
Yiqing He, Nick Martin, Gu Zhu, Yangyang Liu
OBJECTIVE: Two widely studied genetic polymorphisms in the dopaminergic system [DRD4 exon III variable number of tandem repeat (VNTR) and COMT Val158Met] have been reported to be associated with novelty-seeking, but the results have been highly inconsistent. Therefore, a meta-analysis of the associations between these two polymorphisms and novelty-seeking was conducted. PARTICIPANTS AND METHODS: For DRD4, 24 studies comprising 27 samples and including 4933 participants were selected...
December 2018: Psychiatric Genetics
Zahra I Mohamed, Shiau F Tee, Pek Y Tang
INTRODUCTION: In recent years, various studies have accumulated evidence of the involvement of single nucleotide polymorphisms (SNPs) in introns and exons in schizophrenia. The association of functional SNPs in the 3'-untranslated regions with schizophrenia has been explored in a number of studies, but the results are inconclusive because of limited meta-analyses. To systematically analyze the association between SNPs in 3'-untranslated regions and schizophrenia, we conducted a meta-analysis by combining all available studies on schizophrenia candidate genes...
December 2018: Psychiatric Genetics
David Curtis
BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent samples and also with other diseases and traits. AIM: This study aims to explore the distribution of the schizophrenia PRS in subjects of different ancestry. METHODS: The schizophrenia PRS derived from the large genome-wide association study carried out by the Psychiatric Genetics Consortium was calculated using the downloaded genotypes of HapMap subjects from 11 different ancestral groups...
October 2018: Psychiatric Genetics
Becky Inkster, Andy Simmons, James H Cole, Erwin Schoof, Rune Linding, Tom Nichols, Pierandrea Muglia, Florian Holsboer, Philipp G Sämann, Peter McGuffin, Cynthia H Y Fu, Kamilla Miskowiak, Paul M Matthews, Gwyneth Zai, Kristin Nicodemus
OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) has been implicated in mood disorders. We previously reported associations between a GSK3β polymorphism and hippocampal volume in major depressive disorder (MDD). We then reported similar associations for a subset of GSK3β-regulated genes. We now investigate an algorithm-derived comprehensive list of genes encoding proteins that directly interact with GSK3β to identify a genotypic network influencing hippocampal volume in MDD. PARTICIPANTS AND METHODS: We used discovery (N=141) and replication (N=77) recurrent MDD samples...
October 2018: Psychiatric Genetics
Fabian Streit, Jens Treutlein, Ulrich Frischknecht, Derik Hermann, Karl Mann, Falk Kiefer, Markus Sack, Alisha S M Hall, Josef Frank, Stephanie H Witt, Jerome C Foo, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Markus M Nöthen, Wolfgang H Sommer, Rainer Spanagel, Marcella Rietschel, Gabriele Ende
No abstract text is available yet for this article.
October 2018: Psychiatric Genetics
Kanako Ishizuka, Hiroki Kimura, Itaru Kushima, Toshiya Inada, Yuko Okahisa, Masashi Ikeda, Nakao Iwata, Daisuke Mori, Branko Aleksic, Norio Ozaki
Enhanced carbonyl stress has been observed in a subgroup of patients with schizophrenia. Glyoxalase I, which is encoded by GLO1, is an enzyme that protects against carbonyl stress. In this study, we focused on the association between rare genetic variants of GLO1 and schizophrenia. First, we identified one heterozygous frameshift variant, p.P122fs, in 370 Japanese schizophrenia cases with allele frequencies of up to 1% by exon-targeted mutation screening of GLO1. We then performed an association analysis on 1282 cases and 1764 controls with this variant...
October 2018: Psychiatric Genetics
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
İsmail Akaltun, Tayfun Kara
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
Jerome C Foo, Fabian Streit, Jens Treutlein, Stephan Ripke, Stephanie H Witt, Jana Strohmaier, Franziska Degenhardt, Andreas J Forstner, Per Hoffmann, Michael Soyka, Norbert Dahmen, Norbert Scherbaum, Norbert Wodarz, Stefanie Heilmann-Heimbach, Stefan Herms, Sven Cichon, Ulrich Preuss, Wolfgang Gaebel, Monika Ridinger, Sabine Hoffmann, Thomas G Schulze, Wolfgang Maier, Peter Zill, Bertram Müller-Myhsok, Marcus Ising, Susanne Lucae, Markus M Nöthen, Karl Mann, Falk Kiefer, Marcella Rietschel, Josef Frank
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (∼10 fold) larger discovery sample, we calculated PRS based on the second wave (PGC-MDD2) of results, in a severe AD case-control target sample...
August 2018: Psychiatric Genetics
Fei Xu, Yan Bi, Decheng Ren, Yuhao Zhu, Jiaxin Hu, Fan Yuan, Ruixue Yuan, Gaini Ma, Weibo Niu, Zhenming Guo, Qianqian Sun, Xi Wu, Yanfei Cao, Fengping Yang, Lin He, Tao Yu, Lei Cai, Guang He
The distal long arm of chromosome 22 (22q13.3) may harbor genes implicated in schizophrenia. This is evidenced by various genetic mapping studies. BRD1 and its neighboring gene ZBED4, both located within this region, have repeatedly been found to be associated with schizophrenia in the Caucasian population. In this study, we chose seven SNPs (two BRD1 SNPs, five ZBED4 SNPs) to carry out an association study between these two genes and schizophrenia in the Chinese population. However, no significant result was obtained, which was consistent with the Japanese population...
August 2018: Psychiatric Genetics
Subin Park, Hochang Benjamin Lee, Jong-Keuk Lee, Young-Mi Park, Taeyeop Lee, Yangsoon Park, Myeong Hee Ahn, Jin Pyo Hong
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
David Curtis
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with schizophrenia. Such variants are widely dispersed, though concentrated near genes expressed in the brain, and it has been proposed that these SNP associations result from impacts on cell regulatory networks that ultimately affect the expression or function of a modest number of 'core' genes...
August 2018: Psychiatric Genetics
Zuoli Sun, Zhengrong Zhang, Peixian Mao, Yun Ma, Wenbiao Li, Jun Li, Xue Yang, Sihai Ling, Yilang Tang
AIM: Catechol-O-methyltransferase (COMT) gene variants may be involved in the pathogenesis of psychotic symptoms, and associated especially with negative symptom in schizophrenia, but their roles in cognitive function and treatment response remain unclear. The aim of this study was to explore the association between COMT gene polymorphisms, clinical symptoms (including cognitive function), and treatment response to antipsychotic medications in patients with schizophrenia. PATIENTS AND METHODS: A total of 200 Han Chinese inpatients with schizophrenia were recruited in accordance with Diagnostic and Statistical Manual of Mental Disorders, 4th ed...
June 2018: Psychiatric Genetics
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
BACKGROUND: Epigenetic factors have been identified in the past years as interesting candidates for psychiatric disorders and related endophenotypes. It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate. PARTICIPANTS AND METHODS: Seventy-eight healthy Colombian participants (mean age=20...
June 2018: Psychiatric Genetics
Miyuru Chandradasa, Shehan Williams
The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-Giedion syndrome and high-functioning autism. The karyotype found a microdeletion of the long arm of chromosome 8 with mosaicism [46,XY/46,XY,del(8)(q24.1q24.3)]. This is probably the first report of Langer-Giedion Syndrome with autism and the first report of the genetic syndrome from Sri Lanka...
June 2018: Psychiatric Genetics
Aengus ÓConghaile, Diane L Smedberg, Ah L Shin, Lynn E DeLisi
AIMS/OBJECTIVES/BACKGROUND: Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. METHODS: Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder...
April 2018: Psychiatric Genetics
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