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Psychiatric Genetics

David Curtis
BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent samples and also with other diseases and traits. AIM: This study aims to explore the distribution of the schizophrenia PRS in subjects of different ancestry. METHODS: The schizophrenia PRS derived from the large genome-wide association study carried out by the Psychiatric Genetics Consortium was calculated using the downloaded genotypes of HapMap subjects from 11 different ancestral groups...
October 2018: Psychiatric Genetics
Becky Inkster, Andy Simmons, James H Cole, Erwin Schoof, Rune Linding, Tom Nichols, Pierandrea Muglia, Florian Holsboer, Philipp G Sämann, Peter McGuffin, Cynthia H Y Fu, Kamilla Miskowiak, Paul M Matthews, Gwyneth Zai, Kristin Nicodemus
OBJECTIVE: Glycogen synthase kinase 3β (GSK3β) has been implicated in mood disorders. We previously reported associations between a GSK3β polymorphism and hippocampal volume in major depressive disorder (MDD). We then reported similar associations for a subset of GSK3β-regulated genes. We now investigate an algorithm-derived comprehensive list of genes encoding proteins that directly interact with GSK3β to identify a genotypic network influencing hippocampal volume in MDD. PARTICIPANTS AND METHODS: We used discovery (N=141) and replication (N=77) recurrent MDD samples...
October 2018: Psychiatric Genetics
Fabian Streit, Jens Treutlein, Ulrich Frischknecht, Derik Hermann, Karl Mann, Falk Kiefer, Markus Sack, Alisha S M Hall, Josef Frank, Stephanie H Witt, Jerome C Foo, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Markus M Nöthen, Wolfgang H Sommer, Rainer Spanagel, Marcella Rietschel, Gabriele Ende
No abstract text is available yet for this article.
October 2018: Psychiatric Genetics
Kanako Ishizuka, Hiroki Kimura, Itaru Kushima, Toshiya Inada, Yuko Okahisa, Masashi Ikeda, Nakao Iwata, Daisuke Mori, Branko Aleksic, Norio Ozaki
Enhanced carbonyl stress has been observed in a subgroup of patients with schizophrenia. Glyoxalase I, which is encoded by GLO1, is an enzyme that protects against carbonyl stress. In this study, we focused on the association between rare genetic variants of GLO1 and schizophrenia. First, we identified one heterozygous frameshift variant, p.P122fs, in 370 Japanese schizophrenia cases with allele frequencies of up to 1% by exon-targeted mutation screening of GLO1. We then performed an association analysis on 1282 cases and 1764 controls with this variant...
October 2018: Psychiatric Genetics
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
İsmail Akaltun, Tayfun Kara
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
Jerome C Foo, Fabian Streit, Jens Treutlein, Stephan Ripke, Stephanie H Witt, Jana Strohmaier, Franziska Degenhardt, Andreas J Forstner, Per Hoffmann, Michael Soyka, Norbert Dahmen, Norbert Scherbaum, Norbert Wodarz, Stefanie Heilmann-Heimbach, Stefan Herms, Sven Cichon, Ulrich Preuss, Wolfgang Gaebel, Monika Ridinger, Sabine Hoffmann, Thomas G Schulze, Wolfgang Maier, Peter Zill, Bertram Müller-Myhsok, Marcus Ising, Susanne Lucae, Markus M Nöthen, Karl Mann, Falk Kiefer, Marcella Rietschel, Josef Frank
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (∼10 fold) larger discovery sample, we calculated PRS based on the second wave (PGC-MDD2) of results, in a severe AD case-control target sample...
August 2018: Psychiatric Genetics
Fei Xu, Yan Bi, Decheng Ren, Yuhao Zhu, Jiaxin Hu, Fan Yuan, Ruixue Yuan, Gaini Ma, Weibo Niu, Zhenming Guo, Qianqian Sun, Xi Wu, Yanfei Cao, Fengping Yang, Lin He, Tao Yu, Lei Cai, Guang He
The distal long arm of chromosome 22 (22q13.3) may harbor genes implicated in schizophrenia. This is evidenced by various genetic mapping studies. BRD1 and its neighboring gene ZBED4, both located within this region, have repeatedly been found to be associated with schizophrenia in the Caucasian population. In this study, we chose seven SNPs (two BRD1 SNPs, five ZBED4 SNPs) to carry out an association study between these two genes and schizophrenia in the Chinese population. However, no significant result was obtained, which was consistent with the Japanese population...
August 2018: Psychiatric Genetics
Subin Park, Hochang Benjamin Lee, Jong-Keuk Lee, Young-Mi Park, Taeyeop Lee, Yangsoon Park, Myeong Hee Ahn, Jin Pyo Hong
No abstract text is available yet for this article.
August 2018: Psychiatric Genetics
David Curtis
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with schizophrenia. Such variants are widely dispersed, though concentrated near genes expressed in the brain, and it has been proposed that these SNP associations result from impacts on cell regulatory networks that ultimately affect the expression or function of a modest number of 'core' genes...
August 2018: Psychiatric Genetics
Zuoli Sun, Zhengrong Zhang, Peixian Mao, Yun Ma, Wenbiao Li, Jun Li, Xue Yang, Sihai Ling, Yilang Tang
AIM: Catechol-O-methyltransferase (COMT) gene variants may be involved in the pathogenesis of psychotic symptoms, and associated especially with negative symptom in schizophrenia, but their roles in cognitive function and treatment response remain unclear. The aim of this study was to explore the association between COMT gene polymorphisms, clinical symptoms (including cognitive function), and treatment response to antipsychotic medications in patients with schizophrenia. PATIENTS AND METHODS: A total of 200 Han Chinese inpatients with schizophrenia were recruited in accordance with Diagnostic and Statistical Manual of Mental Disorders, 4th ed...
June 2018: Psychiatric Genetics
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
BACKGROUND: Epigenetic factors have been identified in the past years as interesting candidates for psychiatric disorders and related endophenotypes. It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate. PARTICIPANTS AND METHODS: Seventy-eight healthy Colombian participants (mean age=20...
June 2018: Psychiatric Genetics
Miyuru Chandradasa, Shehan Williams
The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-Giedion syndrome and high-functioning autism. The karyotype found a microdeletion of the long arm of chromosome 8 with mosaicism [46,XY/46,XY,del(8)(q24.1q24.3)]. This is probably the first report of Langer-Giedion Syndrome with autism and the first report of the genetic syndrome from Sri Lanka...
June 2018: Psychiatric Genetics
Aengus ÓConghaile, Diane L Smedberg, Ah L Shin, Lynn E DeLisi
AIMS/OBJECTIVES/BACKGROUND: Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. METHODS: Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder...
April 2018: Psychiatric Genetics
Fan Yuan, Ruixue Yuan, Weibo Niu, Decheng Ren, Yan Bi, Fei Xu, Jiaxin Hu, Qianqian Sun, Gaini Ma, Zhenming Guo, Yuhao Zhu, Yanfei Cao, Fengping Yang, Weidong Li, Lei Shi, Lin He, Xingwang Li, Tao Yu, Guang He
No abstract text is available yet for this article.
April 2018: Psychiatric Genetics
Ali Bozorgmehr, Mohammad Ghadirivasfi, Mostafa Tavakoli, Hamid Rahmani, Fahimeh Heydari, Esmaeil Shahsavand Ananloo
OBJECTIVE: In recent decades, the role of genetic factors in the predisposition to suicidal behavior has attracted considerable attention. Although each genetic investigation appears to be valuable, no one study on its own can comprehensively explain the etiology of suicidal behavior. METHODS: In this study, using a broad literature review, we found the suicide-associated gene coexpression network. In addition, cytoband, molecular function, biological process, cellular component, tissue-based expression, and disease/disorder enrichment analyses were carried out to determine the most central cellular and molecular infrastructures involved in suicidal behavior...
April 2018: Psychiatric Genetics
Jiajun Yin, Ningren Jia, Yansong Liu, Chunhui Jin, Fuquan Zhang, Shui Yu, Jun Wang, Jianmin Yuan
BACKGROUND: Schizophrenia (SCZ) is a severe and heritable psychiatric disorder, and previous studies have shown that regulation of the forkhead-box P2 gene (FOXP2) may play a role in schizophrenia. Moreover, just a few studies have identified a single nucleotide polymorphism (SNP) rs10447760 within the gene that was a risk variant for SCZ in the Chinese Han population. METHODS: To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China...
April 2018: Psychiatric Genetics
Ping Wang, Qihao Guo, Yan Zhou, Keliang Chen, Yan Xu, Ding Ding, Zhen Hong, Qianhua Zhao
Recently, several studies have investigated the association between the rare mutation of triggering receptor expressed on myeloid cells 2 (TREM2) gene (rs75932628-T) and the risk of late-onset Alzheimer's disease (LOAD), but they did not draw the same conclusion. Our aim was to investigate the link between the TREM2 polymorphism and LOAD in the Chinese Han population. We examined 786 patients and 803 controls in this study. The rs75932628 polymorphism was evaluated using high-resolution melting analysis and direct sequencing...
February 2018: Psychiatric Genetics
Subha Subramanian, Patricia R Braun, Shizhong Han, James B Potash
The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45). We obtained saliva-derived DNA and use bisulfite pyrosequencing to examine region-specific methylation differences between cases and controls. The region assayed includes 15 CpGs. We found no significant association between the previously implicated CpG and either AN or BN...
February 2018: Psychiatric Genetics
Huan Chen, Yuxi Zhou, Zeng Ge, Qian Li, Qinsheng Sun, Liyuan Zheng, Hong Lv, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools...
February 2018: Psychiatric Genetics
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