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Psychiatric Genetics

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https://www.readbyqxmd.com/read/29734216/associations-between-the-brain-derived-neurotrophic-factor-val66met-polymorphisms-and-suicide-in-patients-with-cancer
#1
Subin Park, Hochang Benjamin Lee, Jong-Keuk Lee, Young-Mi Park, Taeyeop Lee, Yangsoon Park, Myeong Hee Ahn, Jin Pyo Hong
No abstract text is available yet for this article.
May 4, 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29672343/polygenic-risk-score-for-schizophrenia-is-not-strongly-associated-with-the-expression-of-specific-genes-or-gene-sets
#2
David Curtis
BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with schizophrenia. Such variants are widely dispersed, though concentrated near genes expressed in the brain, and it has been proposed that these SNP associations result from impacts on cell regulatory networks that ultimately affect the expression or function of a modest number of 'core' genes...
April 18, 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29634613/association-between-comt-gene-polymorphisms-clinical-symptoms-and-cognitive-functions-in-han-chinese-patients-with-schizophrenia
#3
Zuoli Sun, Zhengrong Zhang, Peixian Mao, Yun Ma, Wenbiao Li, Jun Li, Xue Yang, Sihai Ling, Yilang Tang
AIM: Catechol-O-methyltransferase (COMT) gene variants may be involved in the pathogenesis of psychotic symptoms, and associated especially with negative symptom in schizophrenia, but their roles in cognitive function and treatment response remain unclear. The aim of this study was to explore the association between COMT gene polymorphisms, clinical symptoms (including cognitive function), and treatment response to antipsychotic medications in patients with schizophrenia. PATIENTS AND METHODS: A total of 200 Han Chinese inpatients with schizophrenia were recruited in accordance with Diagnostic and Statistical Manual of Mental Disorders, 4th ed...
April 9, 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29595559/mthfr-gene-methylation-is-associated-with-perceived-stress-in-healthy-young-adults
#4
Karen M Jiménez, Angela J Pereira-Morales, Diego A Forero
BACKGROUND: Epigenetic factors have been identified in the past years as interesting candidates for psychiatric disorders and related endophenotypes. It has been found that the methylenetetrahydrofolate reductase (MTHFR) gene is associated with major depressive disorder, and the aim of the current study was to examine the possible association between perceived stress and MTHFR methylation, taking into account depressive symptoms as a covariate. PARTICIPANTS AND METHODS: Seventy-eight healthy Colombian participants (mean age=20...
June 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29538090/high-functioning-autism-in-a-sri-lankan-youth-with-langer-giedion-syndrome
#5
Miyuru Chandradasa, Shehan Williams
The trichorhinophalangeal syndrome is a rare genetic disorder with a classical clinical triad of sparse hair, bulbous nose, and short digits. There are three known phenotypes, and the type II with exostoses in long bones is known as Langer-Giedion syndrome. Here, we describe a 28-year-old Sri Lankan male with Langer-Giedion syndrome and high-functioning autism. The karyotype found a microdeletion of the long arm of chromosome 8 with mosaicism [46,XY/46,XY,del(8)(q24.1q24.3)]. This is probably the first report of Langer-Giedion Syndrome with autism and the first report of the genetic syndrome from Sri Lanka...
June 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29384891/familial-risk-for-psychiatric-disorders-in-military-veterans-who-have-post-traumatic-stress-disorder-with-psychosis-a-retrospective-electronic-record-review
#6
Aengus ÓConghaile, Diane L Smedberg, Ah L Shin, Lynn E DeLisi
AIMS/OBJECTIVES/BACKGROUND: Post-traumatic stress disorder (PTSD) is a leading cause of morbidity among military veterans, with up to one-in-five individuals with PTSD also having psychotic symptoms. The current study was designed to determine the association between a known family history of psychiatric illness and risk of developing psychosis in patients with PTSD. METHODS: Retrospective medical record review was performed on a cohort study of 414 consecutive individuals admitted to the Veteran Administration in 2014 with a diagnosis of military-related PTSD, but without a prior diagnosis of a psychotic disorder...
April 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29381656/no-association-of-nr3c1-polymorphisms-with-major-depressive-disorder-in-the-chinese-han-population
#7
Fan Yuan, Ruixue Yuan, Weibo Niu, Decheng Ren, Yan Bi, Fei Xu, Jiaxin Hu, Qianqian Sun, Gaini Ma, Zhenming Guo, Yuhao Zhu, Yanfei Cao, Fengping Yang, Weidong Li, Lei Shi, Lin He, Xingwang Li, Tao Yu, Guang He
No abstract text is available yet for this article.
April 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29381655/integrated-analysis-of-the-genetic-basis-of-suicidal-behavior-what-has-been-shown-by-structural-genetic-studies-so-far
#8
Ali Bozorgmehr, Mohammad Ghadirivasfi, Mostafa Tavakoli, Hamid Rahmani, Fahimeh Heydari, Esmaeil Shahsavand Ananloo
OBJECTIVE: In recent decades, the role of genetic factors in the predisposition to suicidal behavior has attracted considerable attention. Although each genetic investigation appears to be valuable, no one study on its own can comprehensively explain the etiology of suicidal behavior. METHODS: In this study, using a broad literature review, we found the suicide-associated gene coexpression network. In addition, cytoband, molecular function, biological process, cellular component, tissue-based expression, and disease/disorder enrichment analyses were carried out to determine the most central cellular and molecular infrastructures involved in suicidal behavior...
April 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29346177/no-association-between-foxp2-rs10447760-and-schizophrenia-in-a-replication-study-of-the-chinese-han-population
#9
Jiajun Yin, Ningren Jia, Yansong Liu, Chunhui Jin, Fuquan Zhang, Shui Yu, Jun Wang, Jianmin Yuan
BACKGROUND: Schizophrenia (SCZ) is a severe and heritable psychiatric disorder, and previous studies have shown that regulation of the forkhead-box P2 gene (FOXP2) may play a role in schizophrenia. Moreover, just a few studies have identified a single nucleotide polymorphism (SNP) rs10447760 within the gene that was a risk variant for SCZ in the Chinese Han population. METHODS: To examine whether the variant in the FOXP2 gene contributes toward SCZ susceptibility, we carried out an association analysis of the SNP rs10447760 of the FOXP2 gene in a case-control study (1405 cases, 1137 controls) from China...
April 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29256968/lack-of-association-between-triggering-receptor-expressed-on-myeloid-cells-2-polymorphism-rs75932628-and-late-onset-alzheimer-s-disease-in-a-chinese-han-population
#10
Ping Wang, Qihao Guo, Yan Zhou, Keliang Chen, Yan Xu, Ding Ding, Zhen Hong, Qianhua Zhao
Recently, several studies have investigated the association between the rare mutation of triggering receptor expressed on myeloid cells 2 (TREM2) gene (rs75932628-T) and the risk of late-onset Alzheimer's disease (LOAD), but they did not draw the same conclusion. Our aim was to investigate the link between the TREM2 polymorphism and LOAD in the Chinese Han population. We examined 786 patients and 803 controls in this study. The rs75932628 polymorphism was evaluated using high-resolution melting analysis and direct sequencing...
February 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29256967/investigation-of-differential-hdac4-methylation-patterns-in-eating-disorders
#11
Subha Subramanian, Patricia R Braun, Shizhong Han, James B Potash
The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45). We obtained saliva-derived DNA and use bisulfite pyrosequencing to examine region-specific methylation differences between cases and controls. The region assayed includes 15 CpGs. We found no significant association between the previously implicated CpG and either AN or BN...
February 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29240020/association-study-of-fgf18-with-developmental-dyslexia-in-chinese-population
#12
Huan Chen, Yuxi Zhou, Zeng Ge, Qian Li, Qinsheng Sun, Liyuan Zheng, Hong Lv, Li-Hai Tan, Yimin Sun
Developmental dyslexia (DD) is a neurobiological disorder featured by reading disabilities. In recent years, genome-wide approaches provided new perspectives to discover novel candidate genes of DD. In a previous study, rs9313548 located downstream of FGF18 showed borderline genome-wide significant association with DD. Herein, we selected rs9313548 and 11 independent tag single nucleotide polymorphisms covering gene region of FGF18 to perform association analysis with DD among 978 Chinese dyslexic cases and 998 controls recruited from elementary schools...
February 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29112096/genetic-analysis-of-common-variants-in-the-znf804a-gene-with-schizophrenia-and-major-depressive-disorder
#13
Qingzhong Wang, Weidong Ji, Kuanjun He, Zhiqiang Li, Jianhua Chen, Wenjin Li, Zujia Wen, Jiawei Shen, Qiang Yu, Guoyin Feng, Jue Ji, Yujiong Wang, Yongyong Shi
AIM/OBJECTIVES/BACKGROUND: ZNF804A has been investigated widely as a candidate susceptibility gene for mental disorders in individuals of different ethnicities. However, in the Han Chinese population, most studies of this gene have focused on associations of the common single nucleotide polymorphism (SNP) rs1344706. METHODS: To investigate additional common variants within ZNF804A, we carried out a case-control study of 13 SNPs distributed across the whole gene, in 1330 schizophrenic patients, 1045 major depressive disorder patients, and 1235 normal controls...
February 2018: Psychiatric Genetics
https://www.readbyqxmd.com/read/29068871/ank3-gene-polymorphisms-and-bipolar-disorder-a-meta-analysis
#14
Yang Roby
OBJECTIVE: Converging evidence has suggested ankyrin 3 (ANK3) as a risk gene for bipolar disorder (BD). However, association studies investigating its genetic variants and BD susceptibility have reported inconsistent results. In the present meta-analysis, we aimed to establish whether ANK3 single nucleotide polymorphisms (SNPs) confer increased risk for BD. METHODS: PubMed, Medline, PsycINFO, Embase, and Scopus were searched for literature published up to January 2017...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29068870/multiple-tissue-methylation-analysis-of-htr2a-exon-i-in-suicidal-behavior
#15
Ali Bani-Fatemi, John Strauss, Clement Zai, Albert H C Wong, Vincenzo de Luca
OBJECTIVE: The main aim of the current study was to investigate epigenetic alterations in serotonin 2A receptor (HTR2A) exon I CpG sites as possible risk factors for suicidal behavior. We also aimed to analyze the epigenetic alterations in two different tissues as epigenetic mechanisms are tissue specific. These epigenetic changes may lead to a better prediction of suicidal behavior. METHODS: Direct CpG methylation analysis was carried out on genomic DNA from the saliva of 20 schizophrenia suicide attempters and 27 non-attempters, and from post-mortem brain tissues of nine suicide victims and 11 controls...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29049139/the-role-of-the-cys23ser-rs6318-polymorphism-of-the-htr2c-gene-in-suicidal-behavior-systematic-review-and-meta-analysis
#16
REVIEW
Thelma B González-Castro, Yazmín Hernandez-Diaz, Isela E Juárez-Rojop, Lilia López-Narváez, Carlos A Tovilla-Zárate, José M Rodriguez-Perez, Juan P Sánchez-de la Cruz
The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide). The results of the meta-analysis were expressed as odds ratios (ORs)...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28737528/genetic-variants-of-increased-waist-circumference-in-psychosis
#17
Dzana S Hukic, Urban Ösby, Eric Olsson, Agneta Hilding, Claes-Göran Östenson, Harvest F Gu, Ewa Ehrenborg, Gunnar Edman, Martin Schalling, Catharina Lavebratt, Louise Frisén
OBJECTIVE: We examined whether established metabolic risk genetic variants in the population confer a risk for increased waist circumference in patients with schizophrenia spectrum disorders and also an association with schizophrenia spectrum disorders irrespective of waist circumference. PATIENTS AND METHODS: We analyzed the association in (i) a case-case model in which patients with schizophrenia spectrum disorder with increased waist circumference (≥80 cm for women and ≥94 cm for men) (n=534) were compared with patients with normal waist circumference (<80 cm for women; <94 cm for men) (n=124), and in (ii) a case-control model in which schizophrenia spectrum disorder patients with increased waist circumference or irrespective of waist circumference were compared with population-derived controls (n=494) adjusted for age, sex, fasting glucose, smoking, and family history of diabetes...
December 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28731911/expert-and-self-assessment-of-lifetime-symptoms-and-diagnosis-of-major-depressive-disorder-in-large-scale-genetic-studies-in-the-general-population-comparison-of-a-clinical-interview-and-a-self-administered-checklist
#18
Jessica Martin, Fabian Streit, Jens Treutlein, Maren Lang, Josef Frank, Andreas J Forstner, Franziska Degenhardt, Stephanie H Witt, Thomas G Schulze, Sven Cichon, Markus M Nöthen, Marcella Rietschel, Jana Strohmaier
Major depression disorder (MDD) is a complex neuropsychiatric disorder and an increasing number of genetic risk variants are being identified. Investigation of their influence in the general population requires accurate and efficient assessment of depressive symptoms. Here, clinical interviews conducted by clinicians are the gold standard. We investigated whether valid and reliable clinical phenotypes can be obtained efficiently using self-administered instruments. Lifetime depressive symptoms and lifetime MDD diagnosis were assessed in 464 population-based individuals using a clinical interview and a structured, self-administered checklist...
October 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28590957/genetic-moderation-of-cocaine-subjective-effects-by-variation-in-the-tph1-tph2-and-slc6a4-serotonin-genes
#19
Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielsen
OBJECTIVE: This study investigated variants of tryptophan hydroxylase (TPH)1, TPH2, and SLC6A4 in the moderation of the subjective effects of cocaine. METHODS: Non-treatment-seeking cocaine-dependent individuals (N=66) were intravenously administered saline and cocaine (40 mg) in a randomized order. Participants self-reported subjective effects of cocaine using a visual analog scale starting before administration of saline or cocaine (-15 min) to up to 20 min after infusion...
October 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28570395/runs-of-homozygosity-copy-number-variation-and-risk-for-depression-and-suicidal-behavior-in-an-arab-bedouin-kindred
#20
Nadine M Melhem, Sami Hamdan, Lambertus Klei, Shawn Wood, Jamie Zelazny, Amos Frisch, Abraham Weizman, Miri Carmel, Elena Michaelovsky, Ilana Farbstein, Danuta Wasserman, Muhammad El-Heib, Robert Ferrell, Alan Apter, Bernie Devlin, David Brent
OBJECTIVES: Inbreeding increases the probability of homozygosity of deleterious alleles. Inbreeding and runs of homozygosity (ROH) are associated with an increased risk for disease phenotypes, including schizophrenia and other psychiatric disorders. The effects of inbreeding, ROH, homozygous deletions, and other copy number variations (CNVs) on risk for depression and suicide attempt (SA) were quantified in an Arab Bedouin Kindred. METHODS: We carried out genetic analyses of 439 individuals from an Arab kindred with high rates of depression and suicidal behavior...
October 2017: Psychiatric Genetics
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