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Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society

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https://www.readbyqxmd.com/read/27913968/post-ganglionic-autonomic-neuropathy-associated-with-anti-glutamic-acid-decarboxylase-antibodies
#1
E Fileccia, R Rinaldi, R Liguori, A Incensi, R D'Angelo, M P Giannoccaro, V Donadio
PURPOSE: Antibodies to glutamic acid decarboxylase (GAD-Abs) have been associated with several conditions, rarely involving the autonomic nervous system. Here, we describe two patients complaining of autonomic symptoms in whom a post-ganglionic autonomic neuropathy has been demonstrated in association with significantly elevated serum and CSF GAD-Abs levels. METHODS: Patients underwent nerve conduction studies, sympathetic skin response testing, evaluation of autonomic control of the cardiovascular system and skin biopsy...
December 2, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27838780/autoimmunity-associated-autonomic-failure-with-sympathetic-denervation
#2
David S Goldstein, Courtney Holmes, Patti Sullivan, Vincenzo Donadio, Risa Isonaka, Elizabeth Zhong, Bobby Pourier, Steven Vernino, Irwin J Kopin, Yehonatan Sharabi
We report a case of autoimmunity-associated autonomic failure in a young adult woman who developed arthritis followed 3 years later by pandysautonomia. There was early recovery of parasympathetic functions but persistent neurogenic orthostatic hypotension from post-ganglionic sympathetic denervation. Clinical laboratory testing indicated variable amounts of sympathetic neuronal re-sprouting in the heart, kidneys, eyes, and body as a whole upon follow-up evaluation after 1.5 years.
November 12, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27838779/acute-cyclooxygenase-inhibition-and-baroreflex-sensitivity-in-lean-and-obese-adults
#3
Abdulrahman A Al-Khateeb, Jacqueline K Limberg, Jill N Barnes, Michael J Joyner, Nisha Charkoudian, Timothy B Curry
PURPOSE: Obese adults exhibit increased levels of inflammation, which may negatively affect blood pressure regulation. Based on existing literature, we hypothesized: (1) baroreflex sensitivity would be lower in obese adults when compared to lean adults; (2) acute ibuprofen (IBU, a cyclooxygenase inhibitor and nonsteroidal antiinflammatory agent) administration would increase baroreflex sensitivity in obese adults, with no effect in lean adults. METHODS: Seven lean (4 male, 3 female) and six obese (5 M, 1 F) adults completed two visits randomized to control (CON) or IBU (800 mg oral)...
November 12, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27787636/changes-in-sympathetic-thermoregulatory-function-with-aging
#4
LETTER
Kazumasa Shindo, Mai Tsuchiya, Nobuo Yamashiro, Fumikazu Kobayashi, Takamura Nagasaka, Yoshihisa Takiyama
We recorded skin sympathetic nerve activity (SSNA), SSR, and SVR in 30 subjects. SSNA and SVR showed a slight decrease and spontaneous changes in resting SSR were significantly less frequent in older subjects compared with younger subjects (p < 0.05). There was no significant relationship between age and the reflex latency or amplitude of SSNA, SSR, and SVR in response to electrical stimulation.
October 27, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27757562/a-case-series-of-rem-sleep-behavior-disorder-in-pure-autonomic-failure
#5
Mitchell G Miglis, Srikanth Muppidi, Emmanuel During, Safwan Jaradeh
PURPOSE: Data on the prevalence of RBD in patients with PAF are limited, with discrepancies in the literature regarding prevalence. We aimed to provide further data on this association with a series of eight patients with PAF. METHODS: We reviewed the electronic medical records of all patients seen at the Stanford neurology clinics from 2012 to 2016 who were given a provisional diagnosis of PAF (343 patients), and further screened by procedure codes to identify those patients who underwent both attended video-polysomonography and autonomic testing (18 patients), and met strict exclusionary criteria (8 patients)...
October 18, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27752785/dexmedetomidine-for-refractory-adrenergic-crisis-in-familial-dysautonomia
#6
Ryan C Dillon, Jose-Alberto Palma, Christy L Spalink, Diana Altshuler, Lucy Norcliffe-Kaufmann, David Fridman, John Papadopoulos, Horacio Kaufmann
OBJECTIVE: Adrenergic crises are a cardinal feature of familial dysautonomia (FD). Traditionally, adrenergic crises have been treated with the sympatholytic agent clonidine or with benzodiazepines, which can cause excessive sedation and respiratory depression. Dexmedetomidine is a centrally-acting α 2-adrenergic agonist with greater selectivity and shorter half-life than clonidine. We evaluated the preliminary effectiveness and safety of intravenous dexmedetomidine in the treatment of refractory adrenergic crisis in patients with FD...
October 17, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27734180/assessment-of-autonomic-symptoms-in-a-medically-complex-urban-patient-population
#7
Jessica Robinson-Papp, Sandeep K Sharma, Mary Catherine George, David M Simpson
PURPOSE: Urban, minority communities are disproportionately affected by the chronic diseases associated with autonomic neuropathy; however validated measures of autonomic symptoms have not been studied in these complex populations. We sought to validate the Autonomic Symptom Profile (ASP) in a low income, medically complex, urban patient population. METHODS: Ninety-seven adults were recruited from the outpatient neurology clinic of an academic medical center serving the East Harlem neighborhood of New York City...
October 12, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27624333/twenty-four-hour-blood-pressure-profile-orthostatic-hypotension-and-cardiac-dysautonomia-in-elderly-type-2-diabetic-hypertensive-patients
#8
Alfredo Costa, Daniele Bosone, Matteo Cotta Ramusino, Natascia Ghiotto, Elena Guaschino, Annalisa Zoppi, Angela D'Angelo, Roberto Fogari
PURPOSE: The aim of this study was to evaluate the relationship between orthostatic hypotension (OH), defined as a decrease in systolic blood pressure (SBP) ≥20 mmHg and/or a decrease in diastolic blood pressure (DBP) ≥10 mmHg, and 24-h ambulatory BP profile in elderly hypertensive type 2 diabetic patients. METHODS: After a 2-week antihypertensive wash-out period, 200 hypertensive well-controlled diabetic outpatients, aged 65-75 years, underwent a clinical examination, including BP measurements, ECG, 24-h ABP monitoring (ABPM), an orthostatic test, and three tests for cardiovascular autonomic function assessment [deep breathing, heart rate (HR) variability, resting HR]...
September 13, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27761674/autonomic-dysfunction-in-pediatric-patients-with-headache-migraine-versus-tension-type-headache
#9
Jonathan Rabner, Alessandra Caruso, David Zurakowski, Lori Lazdowsky, Alyssa LeBel
PURPOSE: To examine symptoms indicating central nervous system (CNS) autonomic dysfunction in pediatric patients with migraine and tension-type headache. METHODS: A retrospective chart review assessed six symptoms (i.e. constipation, insomnia, dizziness, blurry vision, abnormal blood pressure, and cold and clammy palms and soles) indicating central nervous system (CNS) autonomic dysfunction in 231 patients, ages 5-18 years, diagnosed with migraine, tension-type headache (TTH), or Idiopathic Scoliosis (IS)...
December 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27637670/initial-orthostatic-hypotension-in-teenagers-and-young-adults
#10
V K van Wijnen, M P M Harms, I K Go-Schön, B E Westerhof, C T P Krediet, J Stewart, W Wieling
OBJECTIVE: To assess: (1) the frequency of an abnormally large fall in blood pressure (BP) upon standing from supine in patients with initial orthostatic hypotension (IOH); (2) the underlying hemodynamic mechanisms of this fall in BP upon standing from supine and from squatting. METHODS: In a retrospective study of 371 patients (≤30 years) visiting the syncope unit, the hemodynamic response to standing and squatting were studied in 26 patients who were diagnosed clinically with IOH, based on history taking only...
December 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27514609/erratum-to-autonomic-nervous-system-involvement-in-the-giant-axonal-neuropathy-gan-ko-mouse-implications-for-human-disease
#11
Diane Armao, Rachel M Bailey, Thomas W Bouldin, Yongbaek Kim, Steven J Gray
No abstract text is available yet for this article.
December 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27491489/heart-rate-variability-during-sleep-in-children-with-autism-spectrum-disorder
#12
René Harder, Beth A Malow, R Lucas Goodpaster, Fahad Iqbal, Ann Halbower, Suzanne E Goldman, Diane B Fawkes, Lily Wang, Yaping Shi, Franz Baudenbacher, André Diedrich
PURPOSE: Autonomic dysfunction has been reported in autism spectrum disorders (ASD). Less is known about autonomic function during sleep in ASD. The objective of this study is to provide insight into the autonomic cardiovascular control during different sleep stages in ASD. We hypothesized that patients with ASD have lower vagal and higher sympathetic modulation with elevated heart rate, as compared to typical developing children (TD). METHODS: We studied 21 children with ASD and 23 TD children during overnight polysomnography...
December 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27600382/27th-international-symposium-on-the-autonomic-nervous-system
#13
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27568208/autonomic-function-and-brain-volume
#14
Juan M Racosta, Kurt Kimpinski
OBJECTIVE: The aim of this study is to review the evidence on the role of the autonomic nervous system as a determinant of brain volume. Brain volume measures have gained increasing attention given its biological importance, particularly as a measurement of neurodegeneration. METHODS: Using an integrative approach, we reviewed publications addressing the anatomical and physiological characteristics of brain autonomic innervation focusing on evidence from diverse clinical populations with respect to brain volume...
August 27, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27541037/blood-pressure-oscillations-in-baroreflex-failure
#15
Ahmad Rida Abuzinadah, Dong In Sinn, Roy Freeman, Christopher H Gibbons
A 67-year-old man presented with labile hypertension and orthostatic hypotension after radical neck dissection and radiotherapy for squamus cell carcinoma. Baroreflex failure is clearly evident on autonomic testing.
August 19, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27510618/post-exercise-heart-rate-recovery-correlates-to-resting-heart-rate-variability-in-healthy-men
#16
Guilherme Eckhardt Molina, Keila Elizabeth Fontana, Luiz Guilherme Grossi Porto, Luiz Fernando Junqueira
JUSTIFICATIVE: The relationship between post-exercise heart-rate recovery (HRR) and resting cardiac autonomic modulation is an incompletely explored issue. OBJECTIVE: To correlate HRR with resting supine and orthostatic autonomic status. METHOD: HRR at the 1st, 3th, and 5th min following maximal treadmill exercise were correlated with 5-min time-domain (CV, pNN50 and rMSSD) and frequency-domain (TP, LF, HF, LFn, HFn, and LF/HF ratio) indices of heart-rate variability (HRV) in both supine and standing positions in 31 healthy physically active non-athletes men...
August 10, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27506589/sympathetic-neural-and-cardiovascular-responses-during-static-handgrip-exercise-in-women-with-a-history-of-hypertensive-pregnancy
#17
Abigail S L Stickford, Yoshiyuki Okada, Stuart A Best, Rosemary S Parker, Benjamin D Levine, Qi Fu
PURPOSE: Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular disease. The current study examined the hypothesis that women with a hypertensive pregnancy history exhibit an augmented exercise pressor response. METHODS: Normotensive women with a history of healthy pregnancy (CON; n = 9) and hypertensive pregnancy (HP+; n = 12) were studied during the mid-luteal phase of the menstrual cycle...
August 9, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27498096/superficial-siderosis-associated-with-peripheral-autonomic-failure-and-tetraventricular-hydrocephalus-a-case-report
#18
Samir Abu Rumeileh, Valentina Favoni, Francesco Toni, Giulia Pierangeli, Federico Oppi, Giovanna Calandra-Buonaura, David Milletti, Monica Maffei, Luigi Cirillo, Raffaele Agati, Giorgio Palandri, Pietro Cortelli
We describe the case of a man whose initial clinical presentation included sensorineural hearing loss and orthostatic hypotension. The patient was diagnosed with superficial siderosis associated with peripheral autonomic failure and tetraventricular hydrocephalus.
August 6, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27498095/rosiglitazone-influences-adipose-tissue-distribution-without-deleterious-impact-on-heart-rate-variability-in-coronary-heart-disease-patients-with-type-2-diabetes
#19
Audrey Grenier, Patrice Brassard, Olivier F Bertrand, Jean-Pierre Després, Olivier Costerousse, Natalie Alméras, Et Paul Poirier
INTRODUCTION: Obesity is associated with decreased heart rate variability (HRV). Rosiglitazone, a PPARγ agonist, is generally associated with increases in body mass. PURPOSE: To assess whether the gain in body mass and adiposity expected from rosiglitazone treatment has an influence on HRV in patients with type 2 diabetes and coronary artery disease. METHODS: One hundred and twenty-five patients with type 2 diabetes and coronary artery disease aged between 40 and 75 years were studied...
August 6, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27491490/a-case-of-idiopathic-pure-sudomotor-failure-associated-with-prolonged-high-levels-of-serum-carcinoembryonic-antigen
#20
Yoshihiko Nakazato, Naotoshi Tamura, Kei Ikeda, Toshimasa Yamamoto, Yoshiki Tokura
We report a case of idiopathic pure sudomotor failure (IPSF) in which serum carcinoembryonic antigen (CEA) levels elevated at onset, and remained high while anhidrosis lasted. We considered that changes in serum levels of CEA were related to the disease activity of IPSF.
August 4, 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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