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Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society

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https://www.readbyqxmd.com/read/30229336/substantial-renal-conversion-of-l-threo-3-4-dihydroxyphenylserine-droxidopa-to-norepinephrine-in-patients-with-neurogenic-orthostatic-hypotension
#1
Guillaume Lamotte, Courtney Holmes, Patti Sullivan, David S Goldstein
BACKGROUND: The pressor effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa, Northera™) results from conversion of L-DOPS to norepinephrine (NE) in cells expressing L-aromatic-amino-acid decarboxylase (LAAAD). After L-DOPS administration the increase in systemic plasma NE is too small to explain the increase in blood pressure. Renal proximal tubular cells abundantly express LAAAD. Since NE generated locally in the kidneys could contribute to the pressor effect of L-DOPS, in this study we assessed renal conversion of L-DOPS to NE...
September 18, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30225734/concomitant-cardiac-and-cerebral-takotsubo-syndrome-requires-specific-management
#2
LETTER
Josef Finsterer, Claudia Stöllberger
No abstract text is available yet for this article.
September 17, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30209702/autonomic-symptom-burden-is-an-independent-contributor-to-multiple-sclerosis-related-fatigue
#3
Magdalena Krbot Skorić, Luka Crnošija, Ivan Adamec, Barbara Barun, Tereza Gabelić, Tomislav Smoljo, Ivan Stanić, Tin Pavičić, Ivan Pavlović, Jelena Drulović, Tatjana Pekmezović, Mario Habek
OBJECTIVES: To investigate a possible association between autonomic dysfunction and fatigue in people with multiple sclerosis. METHODS: In 70 people with multiple sclerosis early in the disease course (51 females, mean age 33.8 ± 9.1), quantitative sudomotor axon reflex tests, cardiovascular reflex tests (heart rate and blood pressure responses to the Valsalva maneuver and heart rate response to deep breathing), and the tilt table test were performed. Participants completed the Composite Autonomic Symptom Score 31, the Modified Fatigue Impact Scale, and the Epworth Sleepiness Scale, as well as the Beck Depression Inventory...
September 12, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30191428/electrochemical-skin-conductance-to-measure-sudomotor-function-the-importance-of-not-misinterpreting-the-evidence
#4
EDITORIAL
Aaron I Vinik, Carolina M Casellini, Henri K Parson
No abstract text is available yet for this article.
September 6, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30155794/autonomic-regulation-during-sleep-and-wakefulness-a-review-with-implications-for-defining-the-pathophysiology-of-neurological-disorders
#5
REVIEW
Anne M Fink, Ulf G Bronas, Michael W Calik
Cardiovascular and respiratory parameters change during sleep and wakefulness. This observation underscores an important, albeit incompletely understood, role for the central nervous system in the differential regulation of autonomic functions. Understanding sleep/wake-dependent sympathetic modulations provides insights into diseases involving autonomic dysfunction. The purpose of this review was to define the central nervous system nuclei regulating sleep and cardiovascular function and to identify reciprocal networks that may underlie autonomic symptoms of disorders such as insomnia, sleep apnea, restless leg syndrome, rapid eye movement sleep behavior disorder, and narcolepsy/cataplexy...
August 28, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30151691/diagnostic-treatment-dilemma-baroreflex-failure-or-autoimmune-autonomic-ganglionopathy
#6
LETTER
Maureen C Farrell, Alexander S Brenner, Cyndya A Shibao
No abstract text is available yet for this article.
August 27, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30151690/some-thoughts-about-concomitant-transient-global-amnesia-and-takotsubo-syndrome
#7
LETTER
John E Madias
No abstract text is available yet for this article.
August 27, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30141031/does-resistance-training-modulate-cardiac-autonomic-control-a-systematic-review-and-meta-analysis
#8
REVIEW
Pooja Bhati, Jamal Ali Moiz, Geetha R Menon, M Ejaz Hussain
PURPOSE: To systematically evaluate the literature on the effects of resistance training (RT) on cardiac autonomic control in healthy and diseased individuals. METHODS: Electronic databases Pubmed, PEDro, and Scopus were systematically searched from their inception up to June 2018. Randomized controlled trials, quasi-experimental trials, and cross-over controlled trials investigating the effect of RT (of at least 4 weeks duration) on cardiac autonomic control assessed either by linear or non-linear measures of heart rate variability (HRV), baroreflex sensitivity, or post-exercise heart rate recovery were included...
August 23, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30128682/pharmacological-assessment-of-the-arterial-baroreflex-in-a-young-healthy-obese-male-with-extremely-low-baseline-muscle-sympathetic-nerve-activity
#9
LETTER
Anthony V Incognito, Milena Samora, Roberta A Cartafina, Gabriel M N Guimarães, Mauricio Daher, Philip J Millar, Lauro C Vianna
No abstract text is available yet for this article.
August 20, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30128681/heart-rate-variability-in-parkinson-disease-and-idiopathic-rem-sleep-behavior-disorder
#10
Paulo Bugalho, Marcelo Mendonça, Tânia Lampreia, Rita Miguel, Raquel Barbosa, Manuel Salavisa
PURPOSE: Heart rate variability, a marker of autonomic function modulation, is known to be blunted in Parkinson disease, although data remains conflicting and a putative modifying role of REM sleep behavior disorder persists unclarified. METHODS: We assessed ten patients with idiopathic REM sleep behavior disorder patients, 18 patients with Parkinson disease and REM behavior disorder and eight patients with Parkinson disease without REM sleep behavior disorder. Heart rate variability analysis was performed in 5-min epochs selected from wake, Non-REM and REM polysomnography records...
August 20, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30128680/sir-roger-bannister-1929-2018-and-his-lifetime-contributions-to-autonomic-medicine
#11
EDITORIAL
Christopher J Mathias
No abstract text is available yet for this article.
August 20, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30120624/abnormal-venous-postural-control-multiple-sclerosis-specific-change-related-to-gray-matter-pathology-or-age-related-neurodegenerative-phenomena
#12
Dejan Jakimovski, Matthew Topolski, Kana Kimura, Karen Marr, Sirin Gandhi, Deepa P Ramasamy, Niels Bergsland, Jesper Hagemeier, Bianca Weinstock-Guttman, Robert Zivadinov
BACKGROUND: Autonomic nervous system dysfunction has been previously observed in multiple sclerosis (MS) patients. OBJECTIVE: To assess associations between magnetic resonance imaging-detected neuroinflammatory and neurodegenerative pathology and postural venous flow changes indicative of autonomic nervous system function. METHODS: We used a standardized 3T magnetic resonance imaging protocol to scan 138 patients with MS and 49 healthy controls...
August 17, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30094523/concomitant-transient-global-amnesia-and-takotsubo-cardiomyopathy-following-a-stressful-event
#13
LETTER
Logan M Pyle, Fahad J Laghari, Daniel J Kinem
No abstract text is available yet for this article.
August 9, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30076494/neurogenic-lower-urinary-tract-dysfunction-in-multiple-sclerosis-neuromyelitis-optica-and-related-disorders
#14
REVIEW
Ryuji Sakakibara
PURPOSE: Multiple sclerosis (MS), neuromyelitis optica (NMO), and related disorders are major immune-mediated central nervous system diseases affecting the spinal cord. We reviewed the occurrence of neurogenic lower urinary tract dysfunction (NLUTD) in these categories of diseases. METHODS: We systematically reviewed the literature regarding bladder dysfunction in MS, NMO spectrum disorder (NMOSD), and related disorders (acute disseminated encephalomyelitis, acute immune-mediated myelopathy, and meningitis-retention syndrome)...
August 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30074101/outcomes-following-percutaneous-tibial-nerve-stimulation-ptns-treatment-for-neurogenic-and-idiopathic-overactive-bladder
#15
Katarina Ivana Tudor, Jai H Seth, Martina D Liechti, Juliana Ochulor, Gwen Gonzales, Collette Haslam, Zoe Fox, Mahreen Pakzad, Jalesh N Panicker
PURPOSE: Percutaneous tibial nerve stimulation is a minimally invasive neuromodulation technique for treating overactive bladder symptoms. The aim of this study was to assess safety, efficacy and impact on quality of life of percutaneous tibial nerve stimulation in neurological patients reporting overactive bladder symptoms. METHODS: In this retrospective evaluation over 18 months at a tertiary healthcare centre, patients finding first-line treatments for overactive bladder ineffective or intolerable underwent a standard 12-week course of percutaneous tibial nerve stimulation (Urgent PC, Uroplasty)...
August 3, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30043182/bladder-dysfunction-as-the-initial-presentation-of-multiple-system-atrophy-a-prospective-cohort-study
#16
Ryuji Sakakibara, Jalesh Panicker, Sara Simeoni, Tomoyuki Uchiyama, Tatsuya Yamamoto, Fuyuki Tateno, Masahiko Kishi, Yosuke Aiba
OBJECTIVES: Multiple system atrophy (MSA) is a disease that combines autonomic (orthostatic or bladder) with motor [parkinsonian (MSA-P) or cerebellar (MSA-C)] dysfunction. While bladder dysfunction may occur earlier than motor disorders, thus far no prospective study has been available to determine how often and how early bladder autonomic dysfunction predates motor dysfunction in MSA. Therefore, we present data from detailed history-taking in patients with MSA. METHODS: This is a prospective cohort study...
July 24, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30032335/high-resolution-axon-reflex-sweat-testing-for-diagnosis-of-neuropathy
#17
Adam Loavenbruck, Nathan Sit, Vincenzo Provitera, William Kennedy
OBJECTIVE: The aim of this study was to report a method that quantifies axon reflex sweating from individual sweat glands with nanoliter precision. Measurement of the axon reflex is generally expressed as a single variable (e.g., the flare area or total sweat volume). High-definition videography enables precise measurement of sweating from single, axon reflex-stimulated sweat glands (SGs). METHODS: The sudomotor axon reflex was activated in healthy subjects and subjects with peripheral neuropathy by iontophoresis of 10% acetylcholine...
July 21, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30022321/autonomic-dysfunction-in-the-neurological-intensive-care-unit
#18
REVIEW
Max J Hilz, Mao Liu, Sankanika Roy, Ruihao Wang
Autonomic dysfunction is common in neuro-critical care patients and may compromise the function of various organs. Among the many diseases causing or being associated with autonomic dysfunction are traumatic brain injury, cerebrovascular diseases, epilepsy, Guillain-Barré syndrome (GBS), alcohol withdrawal syndrome, botulism and tetanus, among many others. Autonomic dysfunction may afflict various organs and may involve hyper- or hypo-activity of the sympathetic or parasympathetic system. In this short overview, we address only a small number of neuro-intensive care diseases with autonomic dysfunction...
July 18, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30019292/autonomic-involvement-in-guillain-barr%C3%A3-syndrome-an-update
#19
REVIEW
Zoya Zaeem, Zaeem A Siddiqi, Douglas W Zochodne
BACKGROUND: Guillain-Barré syndrome (GBS), an inflammatory, usually demyelinating polyradiculopathy, is characterized by ascending symmetrical limb weakness, sensory disturbances, and absent or reduced deep tendon reflexes. There is extensive literature suggesting that GBS is associated with autonomic dysfunction in up to two-thirds of patients. However, it is interesting that there is still no consensus amongst medical professionals regarding whether GBS patients should be routinely screened for autonomic nervous system (ANS) neuropathy...
July 17, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/30008021/dynamics-of-seizure-induced-behavioral-and-autonomic-arousal
#20
Emilia Toth, Ganne Chaitanya, Michael Pogwizd, Diana Pizarro, Adeel Ilyas, Steven Pogwizd, Sandipan Pati
PURPOSE: Arousal is the most primitive, powerful instinct with survival benefit present in all vertebrates. Even though the arousal systems are classically viewed as "ascending" brainstem phenomena, there is a "descending" cortical feedback system that maintains consciousness. In this study, we provide electrophysiological confirmation that seizures localized to the anterior cingulum can behaviorally manifest as paroxysms of arousal from sleep. METHODS: Temporal dynamics of arousal induced by anterior cingulate seizures were analyzed by using multiple modalities including stereoelectroencephalography (phase lag index and phase amplitude coupling), lead-1 ECG (point-process heart rate variability analysis) and diffusion tractography (DTI)...
July 14, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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