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Journal of Veterinary Medical Science

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https://www.readbyqxmd.com/read/28717065/comparison-of-postoperative-pain-and-inflammation-reaction-in-dogs-undergoing-preventive-laparoscopic-assisted-and-incisional-gastropexy
#1
Tomoya Haraguchi, Shiho Kimura, Harumichi Itoh, Shinpei Nishikawa, Masato Hiyama, Kenji Tani, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yasuho Taura, Kazuhito Itamoto
This study compared the effects of postoperative pain and inflammation reaction after preventive laparoscopic-assisted gastropexy (LAG) and incisional gastropexy (IG) in 10 clinically normal Beagles. Surgical time, incision length, visual analog scale (VAS) score, University of Melbourne Pain Scale (UMPS) score, and plasma C-reactive protein (CRP), plasma cortisol (COR), and serum interleukin-6 (IL-6) levels were evaluated. The VAS and UMPS scores and COR and IL-6 levels were recorded at 0.5, 1, 2, 4, 8, 12, 18 and 24 hr after surgery...
July 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28717064/sildenafil-improves-heart-rate-variability-in-dogs-with-asymptomatic-myxomatous-mitral-valve-degeneration
#2
Prapawadee Pirintr, Nakkawee Saengklub, Vudhiporn Limprasutr, Suwanakiet Sawangkoon, Anusak Kijtawornrat
Myxomatous mitral valve degeneration (MMVD) causes an imbalance of sympathovagal activity resulted in poor cardiac outcomes. Phosphodiesterase-5 inhibitors have been revealed cardioprotective effect in patients with heart diseases. This study aimed to 1) compare the heart rate variability (HRV) between asymptomatic MMVD and healthy dogs and 2) assess long-term effects of sildenafil and enalapril on time- and frequency-domains analyzes. Thirty-four dogs with MMVD stage B1 or B2 and thirteen healthy dogs were recruited into the study...
July 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28717059/pharmacological-effects-of-a-vitamin-k1-2-3-epoxide-reductase-vkor-inhibitor-3-acetyl-5-methyltetronic-acid-on-cisplatin-induced-fibrosis-in-rats
#3
Masashi Uchida, Tomoya Miyoshi, Yohei Miyamoto
Cisplatin (CDDP) is a chemotherapeutic agent that is widely used in the treatment of lymphomas and solid malignancies. However, its clinical usage is limited by its severe side effects in the kidneys. Glomerular and tubular injuries in the kidneys commonly progress to interstitial fibrosis and, ultimately, the end stage of renal failure. We previously reported that 3-acetyl-5-methyltetronic acid (AMT) had inhibitory effects on rat renal vitamin K1 2,3-epoxide reductase (VKOR) in vitro and also suppressed mesangial cell proliferation and, consequently, the formation of fibrosis via the vitamin K-dependent activation of the growth arrest-specific 6 (Gas6)/Axl pathway in anti-Thy-1 glomerulonephritis (Thy-1 GN) in rats...
July 16, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28717112/effect-of-a-single-point-mutation-on-equine-herpes-virus-9-ehv-9-neuropathogenicity-after-intranasal-inoculation-in-a-hamster-model
#4
Asmaa G Saleh, Shehata I Anwar, Osama M Abas, Hoda A Abd-Ellatieff, Mohamed Nasr, Ibrahim Saleh, Hideto Fukushi, Tokuma Yanai
This study aimed to investigate the neuropathogenesis of equine herpes virus 9 (EHV-9) by studying the effects of a single point mutation introduced in two different EHV-9 genes. The two EHV-9 mutants, 14R and 19R, were generated carrying a point mutation in two separate EHV-9 genes. These mutants, along with the wild-type EHV-9, were used to infect a hamster model. The EHV-9- and 19R-infected groups showed earlier and more severe clinical signs of infection than the 14R-infected group. The white blood cells (WBCs) count was significantly increased in both EHV-9- and 19R-infected groups compared to the 14R-infected group at the 4th day post infection (DPI)...
July 15, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28717056/infection-with-paragonimuswestermani-of-boar-hunting-dogs-in-western-japan-maintained-via-artificial-feeding-with-wild-boar-meat-by-hunters
#5
Takao Irie, Yohei Yamaguchi, Pham Ngoc Doanh, Zhi Hong Guo, Shigehisa Habe, Yoichiro Horii, Nariaki Nonaka
Infection of boar-hunting dogs with Paragonimus westermani was investigated in Western Japan. Blood and rectal feces were collected from 441 dogs in the three districts (205 in Kinki, 131 in Chugoku, and 105 in Shikoku District). In a screening ELISA for serum antibody against P. westermani antigen, 195 dogs (44.2%) showed positive reaction. In the 195 dogs, 8 dogs were found excreting P. westermani eggs after molecular analysis of fecal eggs and additional 7 were identified serologically for the parasite infection because of their stronger reactivity against P...
July 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28717055/incidence-of-anaphylactic-reactions-after-propofol-administration-in-dogs
#6
Mamoru Onuma, Misao Terada, Sadaharu Ono, Akiyoshi Murakami, Tomoko Ishida, Tadashi Sano
Propofol is an anesthetic agent suspended in an emulsion system that includes egg yolk lecithin and soybean oil, because of which, there is concern about the use of propofol in patients allergic to these substances. We examined the association between propofol administration and incidence of adverse events in dogs with allergy to egg yolk lecithin and soybean oil. On the basis of the findings of an allergen-specific immunoglobulin E (IgE) test, 14 dogs with high levels (high-IgE group) and 7 dogs with low levels (normal-IgE group) of IgE were selected...
July 14, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28701625/first-report-of-fasciola-larva-infection-in-galbatruncatula-m%C3%A3-ller-1774-gastropoda-lymnaeidae-occurring-in-the-natural-environment-in-hokkaido-japan
#7
Yuma Ohari, Kei Hayashi, Uday Kumar Mohanta, Yasuhiro Kuwahara, Tadashi Itagaki
In Hokkaido, Japan, wild sika deer are highly infected with Fasciola flukes, suggesting that the flukes complete their life cycle via intermediate host snails and definitive host animals occurring in the natural environment. However, infected snails have been found only in cattle farms contaminated with fasciolosis. This study reports the first Fasciola larva infection in Galbatruncatula snails occurring in the Shoro and Atsuma rivers in the natural environment. Molecular analysis revealed that the nad1 haplotype of the larvae was consistent with that of Fasciola adults obtained from sika deer in Hokkaido...
July 13, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28701624/biochemical-characterization-of-aminopeptidase-n2-from-toxoplasma-gondii
#8
Qingwei Li, Honglin Jia, Shinuo Cao, Zhaoxia Zhang, Jun Zheng, Yanqiao Zhang
Aminopeptidase N (APN) is a member of the highly conserved M1 family of metalloproteases, and is considered to be a valuable target for the treatment of a variety of diseases, e.g., cancer, malaria, and coccidiosis. In this study, we identified an APN gene (TgAPN2) in the Toxoplasma gondii genome, and performed a biochemical characterization of the recombinant TgAPN2 (rTgAPN2) protein. Active rTgAPN2 was first produced and purified in Escherichia coli. The catalytic activity of the enzyme was verified using a specific fluorescent substrate, H-Ala-MCA; the rTgAPN2 was relatively active in the absence of added metal ions...
July 13, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28701623/molecular-characterization-of-the-ribosomal-dna-unit-of-sarcocystis-singaporensis-sarcocystis-zamani-and-sarcocystis-zuoi-from-rodents-in-thailand
#9
Vichan Watthanakaiwan, Manakorn Sukmak, Kriengsak Hamarit, Nongnid Kaolim, Worawidh Wajjwalku, Yuttamol Muangkram
Sarcocystis species are heteroxenous cyst-forming coccidian protozoan parasites with a wide host range, including rodents. In this study, Sarcocystis spp. samples were isolated from Bandicota indica, Rattus argentiventer, R. tiomanicus and R. norvegicus across five provinces of Thailand. Two major groups of Sarcocystis cysts were determined in this study: large and small cysts. Sequence comparisons and phylogenetic analyses based on the partial sequences of 28S ribosomal DNA, the large cysts showed that the highest identity value (99%) with the S...
July 13, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690290/rescue-of-an-intracellular-avirulent-rhodococcus-equi-replication-defect-by-the-extracellular-addition-of-virulence-associated-protein-a
#10
Nuttapone Sangkanjanavanich, Masanori Kawai, Tsutomu Kakuda, Shinji Takai
Rhodococcus equi is a facultative intracellular bacterium that can escape from bactericidal mechanisms associated with phagocytosis. Virulence-associated protein A (VapA), encoded on a virulence-associated plasmid, is essential for intracellular survival in macrophages, but its function is not known. Here, we show that the extracellular addition of recombinant glutathione S-transferase (GST)-VapA fusion protein rescued the intracellular replication defect of a mutant lacking the vapA gene. Furthermore, the virulence-plasmid-cured strain could also multiply to nearly wild-type levels by the addition of GST-VapA...
July 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690289/systemic-mycobacteriosis-caused-by-mycobacterium-avium-subspecies-hominissuis-in-a-14-month-old-japanese-black-beef-steer
#11
Tetsuya Komatsu, Nanami Inaba, Keiko Kondo, Reiko Nagata, Satoko Kawaji, Tomoyuki Shibahara
A 14-month-old Japanese black beef steer presented with severe chronic diarrhea and emaciation and was euthanized. Postmortem examination showed thickened and corrugated intestinal mucosa and enlarged granulomatous mesenteric lymph nodes with caseating necrosis. Numerous epithelioid cells and multinucleated giant cells infiltrated in the lamina propria and the submucosal tissue of the intestines. These cells were also observed in the systemic organs. Many acid-fast bacilli were detected in the cytoplasm of these cells and were identified as 'Mycobacterium avium subsp...
July 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690288/genetic-characterization-of-an-h2n2-influenza-virus-isolated-from-a-muskrat-in-western-siberia
#12
Marina Gulyaeva, Kirill Sharshov, Mizuho Suzuki, Ivan Sobolev, Yoshihiro Sakoda, Alexander Alekseev, Mariya Sivay, Lidia Shestopalova, Michael Shchelkanov, Alexander Shestopalov
Thirty-two muskrats (Ondatra zibethicus) were captured for surveillance of avian influenza virus in wild waterfowl and mammals near Lake Chany, Western Siberia, Russia. A/muskrat/Russia/63/2014 (H2N2) was isolated from an apparently healthy muskrat using chicken embryos. Based on phylogenetic analysis, the hemagglutinin and neuraminidase genes of this isolate were classified into the Eurasian avian-like influenza virus clade and closely related to low pathogenic avian influenza viruses (LPAIVs) isolated from wild water birds in Italy and Sweden, respectively...
July 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690287/stroke-volume-variation-svv-and-pulse-pressure-variation-ppv-as-indicators-of-fluid-responsiveness-in-sevoflurane-anesthetized-mechanically-ventilated-euvolemic-dogs
#13
Yusuke Endo, Jun Tamura, Tomohito Ishizuka, Takaharu Itami, Kiwamu Hanazono, Kenjiro Miyoshi, Tadashi Sano, Kazuto Yamashita, William W Muir
Changes in stroke volume variation (SVV) and pulse pressure variation (PPV) in response to fluid infusion were experimentally evaluated during vecuronium infusion and sevoflurane anesthesia in 5 adult, mechanically ventilated, euvolemic, beagle dogs. Sequential increases in central venous pressure (CVP; 3-7[baseline], 8-12, 13-17, 18-22 and 23-27 mmHg) were produced by infusing lactated Ringer's solution and 6% hydroxyethyl starch solution. Heart rate (beats/min), right atrial pressure (RAP, mmHg), pulmonary arterial pressure (PAP, mmHg), pulmonary capillary wedge pressure (PCWP, mmHg), transpulmonary thermodilution cardiac output (TPTDCO, L/min), stroke volume (SV, ml/beat), arterial blood pressure (ABP, mmHg), extravascular lung water (EVLW, ml), pulmonary vascular permeability index (PVPI, calculated), SVV (%), PPV (%) and systemic vascular resistance (SVR, dynes/sec/cm(5)) were determined at each predetermined CVP range...
July 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690279/towards-a-preventive-strategy-for-neosporosis-challenges-and-future-perspectives-for-vaccine-development-against-infection-with-neospora-caninum
#14
Yoshifumi Nishikawa
Neosporosis is caused by the intracellular protozoan parasite Neospora caninum. This major disease-causing pathogen is responsible for inducing abortion in cattle, and these adverse events occur sporadically all over the world, including Japan. Currently, there are no vaccines on the market against infection with N. caninum. Because live and attenuated vaccines against N. caninum have had safety and effectiveness issues, development of a next-generation vaccine is urgently required. To develop a vaccine against neosporosis, my laboratory has been focused on the following: 1) understanding the host immune responses against Neospora infection, 2) identifying vaccine antigens and 3) developing an effective antigen-delivery system...
July 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28690278/cellular-and-soluble-components-decrease-the-viable-pathogen-counts-in-milk-from-dairy-cows-with-subclinical-mastitis
#15
Tomoko Koshiishi, Masako Watanabe, Hajime Miyake, Keiichi Hisaeda, Naoki Isobe
The present study was undertaken to clarify the factors that reduce the viable pathogen count in milk collected from the udders of subclinical mastitic cows during preservation. Milk was centrifuged to divide somatic cells (cellular components, precipitates) and antimicrobial peptides (soluble components, supernatants without fat layer); each fraction was cultured with bacteria, and the number of viable bacteria was assessed prior to and after culture. In 28.8% of milk samples, we noted no viable bacteria immediately after collection; this value increased significantly after a 5-hr incubation of milk with cellular components but not with soluble components (48...
July 7, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28674309/pathogenic-analysis-of-the-pandemic-2009-h1n1-influenza-a-viruses-in-ferrets
#16
Yoshimi Tsuda, Carla Weisend, Cynthia Martellaro, Friederike Feldmann, Elaine Haddock
The pandemic 2009 H1N1 influenza A virus emerged in humans and caused the first influenza pandemic of the 21st century. Mexican isolates, A/Mexico/4108/2009 (H1N1) (Mex4108) and A/Mexico/InDRE4478/2009 (H1N1) (Mex4487) derived from a mild case and from a cluster of severe cases, showed heterogeneity in virulence in a cynomolgus macaque model. To compare the more pathogenic differences, we generated recombinant viruses and compared their virulence in ferrets. Ferrets infected with recombinant Mex4487 displayed a slightly higher rate of viral replication and severe pneumonia in the early stage of infection...
July 3, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28674326/defect-of-rabies-virus-phosphoprotein-in-its-interferon-antagonist-activity-negatively-affects-viral-replication-in-muscle-cells
#17
Satoko Yamaoka, Kazuma Okada, Naoto Ito, Kota Okadera, Hiromichi Mitake, Kento Nakagawa, Makoto Sugiyama
Attenuated derivative rabies virus Ni-CE replicates in muscle cells less efficiently than does the parental pathogenic strain Nishigahara. To examine the mechanism underlying the less efficient replication of Ni-CE, we compared the activities of Ni-CE and Nishigahara phosphoproteins, viral interferon (IFN) antagonists, to suppress IFN-β promoter activity in muscle cells and we demonstrated a defect of Ni-CE phosphoprotein in this ability. Treatment with an IFN-β-neutralizing antibody improved the replication efficiency of Ni-CE in muscle cells, indicating that produced IFN inhibits Ni-CE replication...
June 30, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28659538/pyothorax-induced-by-an-intrathoracic-foreign-body-in-a-miniature-dachshund-migration-of-a-popsicle-stick-from-the-stomach
#18
Yi-Don Choi, Hyun-Jung Han
A four-year-old dachshund presented with a two-week history of pyrexia, depression, and cough. Four months earlier, the owner observed the dog swallow a whole popsicle stick, but the animal showed no clinical signs at that time. Radiography, ultrasonography, and computed tomography confirmed an intrathoracic linear foreign body and pleural effusion in the right thorax. The pleural fluid was bloody and purulent, and contained inflammatory cells and Escherichia coli. The dog was diagnosed with pyothorax induced by a foreign body, and was treated successfully by surgical removal of the foreign body, partial lung lobectomy, thoracic lavage, and antibiotics...
June 29, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28659537/serum-25-hydroxyvitamin-d-concentrations-in-dogs-with-suspected-acute-pancreatitis
#19
Dong-In Kim, Hakhyun Kim, Purum Son, Ji-Houn Kang, Byeong-Teck Kang, Mhan-Pyo Yang
The present study aimed to determine whether circulating serum concentrations of 25-hydroxyvitamin D [25-(OH)D] differed between healthy dogs and dogs with acute pancreatitis (AP). Twenty-two healthy dogs and twenty client-owned dogs with AP were enrolled in the study. Serum concentrations of 25-(OH)D, blood ionized calcium (iCa), and serum C-reactive protein (CRP) were measured. Concentrations of serum 25-(OH)D and blood iCa in dogs with AP were significantly lower than those of healthy dogs, and serum concentrations of CRP in dogs with AP were significantly higher than those of healthy dogs...
June 29, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28652527/hyperglycemia-reduces-pp2a-subunit-b-expression-in-a-middle-cerebral-artery-occlusion-animal-model
#20
Dong-Ju Park, Phil-Ok Koh
Diabetes is a metabolic disorder that worsens clinical outcome following cerebral ischemia. Protein phosphatase 2A (PP2A) is a conserved, heterotrimeric, serine/threonine phosphatase with various cellular functions. PP2A subunit B is abundant in brain tissue and modulates PP2A function. The aim of this study was to investigate PP2A subunit B protein expression in the cerebral cortex of non-diabetic and diabetic animals with middle cerebral artery occlusion (MCAO) injury. Sprague-Dawley rats were injected with streptozotocin (40 mg/kg, i...
June 26, 2017: Journal of Veterinary Medical Science
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