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Cell Proliferation

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https://www.readbyqxmd.com/read/28090705/osteogenic-differentiation-potential-of-adipose-derived-stem-cells-from-ovariectomized-mice
#1
Lei Wang, Chenglong Huang, Qing Li, Xiaomei Xu, Lin Liu, Kui Huang, Xiaoxiao Cai, Jingang Xiao
OBJECTIVES: Osteoporosis (OP) is a systemic disease caused by imbalance between bone resorption and bone formation, commonly resulting from post-menopausal oestrogen deficiency. Although osteogenic differentiation potential of adipose-derived stem cells (ASCs) has been demonstrated, the effect of OP on osteogenic differentiation of ASCs remains unclear. Here, our work has been designed to compare proliferative capacity and osteogenic differentiation ability of ASCs obtained from osteoporotic mice and normal control mice...
January 16, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28071833/co-culture-with-macrophages-enhances-the-clonogenic-and-invasion-activity-of-endometriotic-stromal-cells
#2
Rachel W S Chan, Cheuk-Lun Lee, Ernest H Y Ng, William S B Yeung
OBJECTIVE: To study the effect on endometrial and endometriotic cells after co-culture with macrophages, using clonogenic, invasion and self-renewal assays. MATERIALS AND METHODS: Peripheral blood samples, endometrium and endometriotic tissues were collected. Autologous macrophages were co-cultured with endometrial and endometriotic cells. The number of colony-forming units (CFU), invasiveness and self-renewal activity after co-culture with macrophages were determined...
January 10, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28054407/from-genetics-to-epigenetics-new-insights-into-keloid-scarring
#3
REVIEW
Yongjing He, Zhenjun Deng, Mansour Alghamdi, Lechun Lu, Mark W Fear, Li He
Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars...
January 5, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/27981756/maternal-diabetes-modulates-offspring-cell-proliferation-and-apoptosis-during-odontogenesis-via-the-tlr4-nf-%C3%AE%C2%BAb-signalling-pathway
#4
Guoqing Chen, Wenhua Sun, Yan Liang, Tian Chen, Weihua Guo, Weidong Tian
OBJECTIVES: Maternal gestational diabetes leads to an adverse in utero environment and increases the risk of malformations during embryo organogenesis. In the present study, we analysed the effects of maternal diabetes on tooth germ cell proliferation and apoptosis in offspring, and investigated their underlying mechanisms. MATERIALS AND METHODS: A rat model of maternal diabetes was induced by intraperitoneal injection of streptozotocin and the pregnant rats were divided into three groups: controls, the diabetic group and diabetic group with insulin treatment...
December 16, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27976431/inhibition-of-adipose-tissue-ppar%C3%AE-prevents-increased-adipocyte-expansion-after-lipectomy-and-exacerbates-a-glucose-intolerant-phenotype
#5
A D Booth, A M Magnuson, K A Cox-York, Y Wei, D Wang, M J Pagliassotti, M T Foster
OBJECTIVES: Adipose tissue plays a fundamental role in glucose homeostasis. For example, fat removal (lipectomy, LipX) in lean mice, resulting in a compensatory 50% increase in total fat mass, is associated with significant improvement in glucose tolerance. This study was designed to further examine the link between fat removal, adipose tissue compensation and glucose homeostasis using a peroxisome proliferator-activated receptor γ (PPAR γ; activator of adipogenesis) knockout mouse...
December 15, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27976428/long-intragenic-non-coding-rna-lincrna-p21-suppresses-development-of-human-prostate-cancer
#6
Xiaohai Wang, Yuan Ruan, Xingjie Wang, Wei Zhao, Qi Jiang, Chenyi Jiang, Yuyang Zhao, Yongzhi Xu, Feng Sun, Yiping Zhu, Shujie Xia, Dongliang Xu
OBJECTIVES: Prostate cancer is one of the most frequent malignancies in men, worldwide, although its underlying mechanisms are not fully understood. Long non-coding RNAs participate in development of human cancers. In this invetsigation, we aimed to study the roles of lincRNA-p21 in development of human prostate cancer. MATERIALS AND METHODS: Expression of lincRNA-p21 was assessed by real-time PCR in cell lines and in human tissues. Lentivirus carrying sh-lincRNA-p21, lincRNA-p21 or control constructs were used to determine their effects on cell proliferation and apoptosis...
December 14, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27943459/protective-roles-of-melatonin-in-central-nervous-system-diseases-by-regulation-of-neural-stem-cells
#7
REVIEW
Xin Yu, Zheng Li, Heyi Zheng, Jeffery Ho, Matthew T V Chan, William Ka Kei Wu
Neural stem cells (NSCs) are immature precursors of the central nervous system (CNS), with self-renewal and multipotential differentiation abilities. Their proliferation and differentiation are dynamically regulated by hormonal and local factors. Alteration in neurogenesis is associated with many neurological disorders. Increasing evidence suggests that modulation of NSCs can be a promising therapeutic approach for neural injury and neurodegenerative disorders. Melatonin, a pineal gland-derived hormone, regulates the neuroimmuno-endocrine axis and is functionally important to the circadian rhythm, tumour suppression and immunity...
December 12, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27910163/serum-amyloid-a-an-acute-phase-protein-stimulates-proliferative-and-proinflammatory-responses-of-keratinocytes
#8
Ning Yu, Shujie Zhang, Jiajing Lu, Ying Li, Xuemei Yi, Li Tang, Lina Su, Yangfeng Ding
OBJECTIVES: Serum amyloid A (SAA), an acute phase protein, is highly expressed in psoriatic lesions but its function is not fully understood. The aim of this study was to explore its role in activation of keratinocytes. MATERIALS AND METHODS: Real-time PCR and immunofluorescence were performed to examine SAA expression in imiquimod (IMQ)-induced psoriasis-like mice. In vivo function of SAA was examined by treating psoriasis-like mice with SAA neutralising antibody...
December 2, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27910161/mir-29a-regulates-vascular-neointimal-hyperplasia-by-targeting-yy1
#9
Yu Zhang, Yong Hui Li, Chao Liu, Chan-Juan Nie, Xin-Hua Zhang, Cui-Ying Zheng, Wen Jiang, Wei-Na Yin, Ming-Hui Ren, Yu-Xin Jin, Shu-Feng Liu, Bin Zheng, Jin-Kun Wen
OBJECTIVES: The formation of vascular neointima is mainly related to impairment of the vascular endothelial barrier and abnormal proliferation and migration of smooth muscle cells. The objective of this study was to investigate whether miR-29a exerts any promoting effect on the vascular neointimal hyperplasia and if so, its mechanism. MATERIALS AND METHODS: RT-qPCR was performed to determine expression of miR-29a in vascular smooth muscle cells (VSMC) and vascular neointimal hyperplasia...
December 2, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27905670/induced-pluripotent-stem-cells-as-a-new-getaway-for-bone-tissue-engineering-a-systematic-review
#10
REVIEW
Farshid Bastami, Pantea Nazeman, Hamidreza Moslemi, Maryam Rezai Rad, Kazem Sharifi, Arash Khojasteh
OBJECTIVES: Mesenchymal stem cells (MSCs) are frequently used for bone regeneration, however, they are limited in quantity. Moreover, their proliferation and differentiation capabilities reduce during cell culture expansion. Potential application of induced pluripotent stem cells (iPSCs) has been reported as a promising alternative source for bone regeneration. This study aimed to systematically review the available literature on osteogenic potential of iPSCs and to discuss methods applied to enhance their osteogenic potential...
December 1, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27878916/can-the-outcomes-of-mesenchymal-stem-cell-based-therapy-for-myocardial-infarction-be-improved-providing-weapons-and-armour-to-cells
#11
REVIEW
Andrey A Karpov, Daria V Udalova, Michael G Pliss, Michael M Galagudza
Use of mesenchymal stem cell (MSC) transplantation after myocardial infarction (MI) has been found to have infarct-limiting effects in numerous experimental and clinical studies. However, recent meta-analyses of randomized clinical trials on MSC-based MI therapy have highlighted the need for improving its efficacy. There are two principal approaches for increasing therapeutic effect of MSCs: (i) preventing massive MSC death in ischaemic tissue and (ii) increasing production of cardioreparative growth factors and cytokines with transplanted MSCs...
November 23, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27878894/downregulation-of-b-myb-promotes-senescence-via-the-ros-mediated-p53-p21-pathway-in-vascular-endothelial-cells
#12
Zhihui Zhou, Yanlin Yin, Qun Chang, Guanqun Sun, Jiahui Lin, Yalei Dai
OBJECTIVES: To reveal whether B-myb is involved in preventing senescence of vascular endothelial cells, and if so, to identify possible mechanisms for it. MATERIALS AND METHODS: C57/BL6 male mice and primary human aortic endothelial cells (HAECs) were used. Bleomycin was applied to induce stress-related premature senescence. B-myb knockdown was achieved using an siRNA technique and cell senescence was assessed using the senescence-associated β-galactosidase (SA-β-gal) assay...
November 23, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27868268/p38-mapk-pathway-is-essential-for-self-renewal-of-mouse-male-germline-stem-cells-mgscs
#13
Zhiwei Niu, Hailong Mu, Haijing Zhu, Jiang Wu, Jinlian Hua
OBJECTIVES: Male germline stem cells (mGSCs), also called spermatogonial stem cells (SSCs), constantly generate spermatozoa in male animals. A number of preliminary studies on mechanisms of mGSC self-renewal have previously been conducted, revealing that several factors are involved in this regulated process. The p38 MAPK pathway is widely conserved in multiple cell types in vivo, and plays an important role in cell proliferation, differentiation, inflammation and apoptosis. However, its role in self-renewal of mGSCs has not hitherto been determined...
November 21, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27868267/reduced-microrna-188-3p-expression-contributes-to-apoptosis-of-spermatogenic-cells-in-patients-with-azoospermia
#14
Wen-Yan Song, Hui Meng, Xue-Gai Wang, Hai-Xia Jin, Gui-Dong Yao, Sen-Lin Shi, Liang Wu, Xiang-Yang Zhang, Ying-Pu Sun
BACKGROUND AND AIMS: Human mutL homologl (MLH1) works coordinately in sequential steps to initiate repair of DNA mismatches, and aberrant MLH1 expression is related to spermatogenetic malfunction. In the present study, MLH1 expression in patients with azoospermia was investigated, and moderating effects of miR-188-3p on MLH1 expression and spermatogenesis were identified. METHODS: Testicular tissues from 16 patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), and tissues of eight healthy patients were collected...
November 21, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27868262/adipocytes-enhance-expression-of-osteoclast-adhesion-related-molecules-through-the-cxcl12-cxcr4-signalling-pathway
#15
Tingting Luo, Hongrui Liu, Wei Feng, Di Liu, Juan Du, Jing Sun, Wei Wang, Xiuchun Han, Jie Guo, Norio Amizuka, Xianqi Li, Minqi Li
OBJECTIVES: The purpose of this study was to investigate effects of adipocytes on osteoclast adhesion-related molecules. MATERIALS AND METHODS: ST2 cells, a cloned stromal cell line from mouse bone marrow, able to differentiate into adipocytes, were cultured in serum-free α-MEM which was then collected to be used as adipocyte-conditioned medium (ADIPO CM). RAW264.7 cells were cultured in ADIPO CM in the presence of RANKL, and bone marrow-derived macrophages were cultured in ADIPO CM in the presence of RANKL and macrophage-colony stimulating factor to induce osteoclast differentiation...
November 21, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27862498/all-trans-retinoic-acid-preconditioning-enhances-proliferation-angiogenesis-and-migration-of-mesenchymal-stem-cell-in-vitro-and-enhances-wound-repair-in-vivo
#16
M Pourjafar, M Saidijam, K Mansouri, H Ghasemibasir, F Karimi Dermani, R Najafi
OBJECTIVES: Stem cell therapy is considered to be a suitable alternative in treatment of a number of diseases. However, there are challenges in their clinical application in cell therapy, such as to reduce survival and loss of transplanted stem cells. It seems that chemical and pharmacological preconditioning enhances their therapeutic efficacy. In this study, we investigated effects of all-trans retinoic acid (ATRA) on survival, angiogenesis and migration of mesenchymal stem cells (MSCs) in vitro and in a wound-healing model...
November 10, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27859817/lncrnas-novel-players-in-intervertebral-disc-degeneration-and-osteoarthritis
#17
REVIEW
Wen-Kang Chen, Xiao-Hua Yu, Wei Yang, Cheng Wang, Wen-Si He, Yi-Guo Yan, Jian Zhang, Wen-Jun Wang
The term long non-coding RNA (lncRNA) refers to a group of RNAs with length more than 200 nucleotides, limited protein-coding potential, and having widespread biological functions, including regulation of transcriptional patterns and protein activity, formation of endogenous small interfering RNAs (siRNAs) and natural microRNA (miRNA) sponges. Intervertebral disc degeneration (IDD) and osteoarthritis (OA) are the most common chronic, prevalent and age-related degenerative musculoskeletal disorders. Numbers of lncRNAs are differentially expressed in human degenerative nucleus pulposus tissue and OA cartilage...
November 9, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27790820/role-of-alpha-and-beta-adrenergic-receptors-in-cardiomyocyte-differentiation-from-murine-induced-pluripotent-stem-cells
#18
Xiao-Li Li, Di Zeng, Yan Chen, Lu Ding, Wen-Ju Li, Ting Wei, Dong-Bo Ou, Song Yan, Bin Wang, Qiang-Sun Zheng
OBJECTIVES: Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adrenergic receptors (ARs) in stem cells after differentiation; however, roles of ARs in fate specification of stem cells, particularly in cardiomyocyte differentiation and development, have not been characterized...
October 27, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27790757/long-non-coding-rna-foxp4-as1-is-an-unfavourable-prognostic-factor-and-regulates-proliferation-and-apoptosis-in-colorectal-cancer
#19
Juan Li, Yifan Lian, Changsheng Yan, Zeling Cai, Jie Ding, Zhonghua Ma, Peng Peng, Keming Wang
OBJECTIVES: Despite improvements in diagnosis and treatment, colorectal cancer (CRC) remains the third most common malignancy, and fourth-leading cause of cancer-related death worldwide, and has a particularly high incidence in Western countries. Recent studies have suggested that long non-coding RNAs (lncRNAs) compose a novel class of regulators of cancer biological processes, such as proliferation, apoptosis and metastasis. Here, we report that lncRNA FOXP4-AS1 acts as a functional oncogene in CRC pathogenesis...
October 27, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27666957/f-actin-rearrangement-is-regulated-by-mtorc2-akt-girdin-in-mouse-fertilized-eggs
#20
Didi Wu, Dahai Yu, Xiuxia Wang, Bingzhi Yu
: In mouse fertilized eggs, correct assembly and distribution of the actin cytoskeleton are intimately related to cleavage in early-stage embryos. However, in mouse fertilized eggs, mechanisms and involved factors responsible for regulating the actin cytoskeleton are poorly defined. In this study, mTORC2, PKB/Akt and Girdin were found to modulate division of mouse fertilized eggs by regulating distribution of the actin cytoskeleton. RNA interference (RNAi)-mediated depletion of mTORC2, Akt1 or Girdin disrupted F-actin rearrangement and strongly inhibited egg development...
December 2016: Cell Proliferation
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