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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/27901447/multivariate-analysis-of-thyrotropin-in-preterm-newborns-based-on-adequacy-of-weight-for-gestational-age
#1
Vicente María Bosch-Giménez, Antonio Palazón-Bru, Álvaro Blasco-Barbero, Mercedes Juste-Ruiz, María Mercedes Rizo-Baeza, Ernesto Cortés-Castell
BACKGROUND: Different and conflicting data have been published concerning thyroid-stimulating hormone (TSH) levels among small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) newborns. The hypothesis of our study was that SGA preterm infants have higher TSH levels than those who are not underweight. METHODS: This cross-sectional study analysed the TSH levels of all preterm newborns with a negative congenital hypothyroidism screening result (TSH<7...
November 30, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27796194/aplp2-rrm2-and-prc1-new-putative-markers-for-the-differential-diagnosis-of-thyroid-follicular-lesions
#2
Esmeralda Castelblanco, Carles Zafon, Javier Maravall, Pilar Gallel, Montserrat Martinez, Ismael Capel, Maria Rosa Bella, Irene Halperin, Jordi Temprana, Carmela Iglesias, Manel Puig-Domingo, Mercedes Robledo, Xavier Matias-Guiu, Didac Mauricio
BACKGROUND: Current methods based on fine-needle aspiration biopsy (FNAB) are not sufficient to distinguish among follicular thyroid lesions, follicular adenoma (FA), follicular thyroid carcinoma (FTC), and the follicular variant of papillary thyroid cancer (FVPTC). Furthermore, none of the immunohistochemical markers currently available are sensitive or specific enough to be used in the clinical setting, necessitating a diagnostic hemithyroidectomy. The aim of this study was to identify proteins of value for differential diagnosis between benign and malignant thyroid follicular lesions...
November 30, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27897088/negligible-thyroid-hormone-content-present-in-nonprescription-u-s-weight-loss-products
#3
Christian D Seger, Xuemei He, Lewis E Braverman, Michael W Yeh, Victor Bernet, Ravinder Singh, Connie M Rhee, Angela M Leung
No abstract required: Submission is a Letter to the Editor.
November 29, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27785980/real-time-genomic-characterization-utilizing-circulating-cell-free-dna-in-patients-with-anaplastic-thyroid-carcinoma
#4
Vlad C Sandulache, Michelle D Williams, Stephen Y Lai, Charles Lu, William N William, Naifa L Busaidy, Gilbert J Cote, Rajesh R Singh, Rajyalakshmi Luthra, Maria E Cabanillas
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is an aggressive disease that requires rapid diagnosis and multimodality treatment. Recent advances in targeted therapeutics have provided ATC patients with previously unavailable treatment options, which may improve clinical outcomes in the coming years. Continued development of high-throughput next-generation sequencing provides clinicians with an unparalleled ability to characterize the genomic background of tumors in order to guide treatment selection and clinical trial enrollment...
November 29, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27750020/variable-cold-induced-brown-adipose-tissue-response-to-thyroid-hormone-status
#5
Alina Gavrila, Per-Olof Hasselgren, Allison Glasgow, Ashley N Doyle, Alice J Lee, Peter Fox, Shiva Gautam, James V Hennessey, Gerald M Kolodny, Aaron M Cypess
BACKGROUND: In addition to its role in adaptive thermogenesis, brown adipose tissue (BAT) may protect from weight gain, insulin resistance/diabetes, and metabolic syndrome. Prior studies have shown contradictory results regarding the influence of thyroid hormone (TH) levels on BAT volume and activity. The aim of this pilot study was to gain further insights regarding the effect of TH treatment on BAT function in adult humans by evaluating the BAT mass and activity prospectively in six patients, first in the hypothyroid and then in the thyrotoxic phase...
November 29, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27784193/successful-management-of-a-patient-with-malignant-thyroid-teratoma
#6
Guilherme Rabinowits, Justine Barletta, Lynette M Sholl, Encarnacion Reche, Jochen Lorch, Laura Goguen
BACKGROUND: Malignant thyroid teratomas are rare tumors with a poor prognosis. Little is known about their pathogenesis or treatment. Here, the case is reported of an adult woman with an aggressive thyroid teratoma with primitive neuroectodermal tumor (PNET) malignant transformation, successfully managed with neoadjuvant chemotherapy and surgery. PATIENT FINDINGS: Sequencing of paired tumor and normal tissues revealed a DICER1 c.5438A>G (p.E1813G) somatic mutation in 56% of sequencing reads consistent with a driver event...
November 28, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27774839/differences-in-brain-glucose-metabolism-during-preparation-for-131-i-ablation-in-thyroid-cancer-patients-thyroid-hormone-withdrawal-versus-recombinant-human-thyrotropin
#7
Hyeonseok S Jeong, Eun Kyoung Choi, In-Uk Song, Yong-An Chung, Jong-Sik Park, Jin Kyoung Oh
BACKGROUND: In preparation for (131)I ablation, temporary withdrawal of thyroid hormone is commonly used in patients with thyroid cancer after total thyroidectomy. The current study aimed to investigate brain glucose metabolism and its relationships with mood or cognitive function in these patients using (18)F-fluoro-2-deoxyglucose positron emission tomography ((18)F-FDG-PET). METHOD: A total of 40 consecutive adult patients with thyroid carcinoma who had undergone total thyroidectomy were recruited for this cross-sectional study...
November 28, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27762727/should-level-v-be-routinely-dissected-in-n1b-papillary-thyroid-carcinoma
#8
Seo Ki Kim, Inhye Park, Nayoon Hur, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: For N1b papillary thyroid carcinoma (PTC) patients, modified radical neck dissection (MRND) encompassing levels II-V is generally recommended. However, routine level V dissection is controversial because of the low incidence of metastasis/recurrence in level V and the increased morbidities associated with level V dissection. METHODS: This study retrospectively reviewed 646 N1b PTC patients who underwent unilateral MRND between January 1997 and June 2015...
November 28, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27758136/competency-education-of-primary-care-physicians-in-management-of-thyroid-disorders-implementation-experiences-from-a-pan-india-certificate-course
#9
Sandeep Bhalla, Deepak Monga, Tanu Soni, Anirudh Gaurang, Shailesh R Deshpande, Anjali Bhatt, Dorairaj Prabhakaran, Ambika Gopalakrishnan Unnikrishnan
No abstract text is available yet for this article.
November 28, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27881037/a-novel-gel-pad-laryngeal-ultrasound-lus-for-vocal-cord-evaluation
#10
Jung-Woo Woo, Seo Ki Kim, Inhye Park, Jun-Ho Choe, Jung Han Kim, Jee Soo Kim
Background Laryngeal ultrasound (LUS) is a new method for vocal cord (VC) evaluation in patients with risk of vocal cord palsy (VCP). However, the previously described LUS reportedly had a high failure rate of VC visualization in male patients. We devised a novel gel pad LUS to overcome the limitations of the previous method. Methods A total of 482 (100 male, 382 female) consecutive LUS and direct laryngoscopy (DL) examinations were performed in thyroidectomy and other neck surgery patients. The conventional LUS and gel pad LUS were used for all patients...
November 23, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27869547/dynamic-risk-stratification-for-predicting-recurrence-in-patients-with-differentiated-thyroid-cancer-treated-without-radioactive-iodine-remnant-ablation-therapy
#11
Suyeon Park, Won Gu Kim, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, MinJi Jeon, Tae Yong Kim, YoungKee Shong, Won Bae Kim
BACKGROUND: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy. METHODS: This historical cohort study included 357 patients with DTC treated with lobectomy or total thyroidectomy without RAI therapy...
November 21, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27762734/a-japanese-family-with-central-hypothyroidism-caused-by-a-novel-igsf1-mutation
#12
Satsuki Nishigaki, Takashi Hamazaki, Keinosuke Fujita, Shuntaro Morikawa, Toshihiro Tajima, Haruo Shintaku
BACKGROUND: Hemizygous mutations in the immunoglobulin superfamily member 1 (IGSF1) gene have been demonstrated to cause congenital central hypothyroidism in males. This study reports a family with a novel mutation in the IGSF1 gene located on the long arm of the X chromosome. PATIENT FINDINGS: A two-month-old boy was diagnosed with central hypothyroidism because of prolonged jaundice. A thyrotropin-releasing hormone (TRH) stimulation test indicated dysfunction in both the hypothalamus and the pituitary gland, and prompted the IGSF1 gene to be analyzed...
November 21, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27762670/estimation-of-second-primary-cancer-risk-after-treatment-with-radioactive-iodine-for-differentiated-thyroid-carcinoma
#13
Nilton Lavatori Corrêa, Lidia Vasconcellos de Sá, Rossana Corbo Ramalho de Mello
BACKGROUND: An increase in the incidence of second primary cancers is the late effect of greatest concern that could occur in differentiated thyroid carcinoma (DTC) patients treated with radioactive iodine (RAI). The decision to treat a patient with RAI should therefore incorporate a careful risk-benefit analysis. The objective of this work was to adapt the risk-estimation models developed by the Biological Effects of Ionizing Radiation Committee to local epidemiological characteristics in order to assess the carcinogenesis risk from radiation in a population of Brazilian DTC patients treated with RAI...
November 21, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27762730/tshr-gene-polymorphisms-in-the-enhancer-regions-are-most-strongly-associated-with-the-development-of-graves-disease-especially-intractable-disease-and-of-hashimoto-s-disease
#14
Asami Fujii, Naoya Inoue, Mikio Watanabe, Chisa Kawakami, Yoh Hidaka, Yoshihide Hayashizaki, Yoshinori Iwatani
BACKGROUND: Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid disorders distinguished by the presence or absence of antithyrotropin receptor (TSHR) antibodies (TRAb). TSHR gene polymorphisms determine the amount of TSHR expressed, which may in turn influence TRAb production. The FANTOM5 project identified six GD-associated single nucleotide polymorphisms (SNPs) within the enhancer regions of the TSHR and unknown genes. This study examined the association of 11 TSHR and unknown gene polymorphisms, five of which are located in TSHR enhancer regions, with the development and prognosis of GD and HD...
November 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27762729/thyroglobulin-as-a-functional-biomarker-of-iodine-status-in-a-cohort-study-of-pregnant-women-in-the-united-kingdom
#15
Sarah C Bath, Victor J M Pop, Victoria L Furmidge-Owen, Maarten A C Broeren, Margaret P Rayman
BACKGROUND: Though iodine deficiency in pregnancy is a matter of public-health concern, a functional measure of iodine status is lacking. The thyroid-specific protein thyroglobulin (Tg), which reflects thyroid size, has shown promise as a functional measure in studies of children and adults, but data in pregnancy are sparse. In a cohort of mildly to moderately iodine-deficient pregnant women, this study aimed to explore whether serum Tg is a sensitive functional biomarker of iodine status and to examine longitudinal change in Tg with gestational age...
November 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27855574/previous-external-beam-radiation-treatment-exposure-does-not-confer-worse-outcome-for-patients-with-differentiated-thyroid-cancer
#16
Manish A Shaha, Laura Y Wang, Jocelyn C Migliacci, Frank L Palmer, Iain James Nixon, R Michael Tuttle, Ashok R Shaha, Jatin P Shah, Snehal G Patel, Ian Ganly
Background Radiation exposure, especially in childhood, is known to increase the risk for the development of thyroid cancer. However, the prognosis of patients with thyroid cancer with a history of radiation treatment exposure remains unclear. Methods One hundred and sixteen patients with a previous history of radiotherapy in the head and neck region were identified from an institutional database of 3664 patients with differentiated thyroid cancer treated between 1986 and 2010. Disease Specific Survival (DSS) and Recurrence Free Survival (RFS) were compared between patients with (RT n=116) and without a prior history of radiation exposure (No RT n=3509), using the Kaplan Meier method...
November 17, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27852155/predictions-on-the-role-of-thyronamines-in-the-setting-of-the-oracle-of-delphi
#17
Leonidas H Duntas
No abstract.
November 16, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27849443/fusion-oncogenes-are-the-main-genetic-events-found-in-sporadic-papillary-thyroid-carcinomas-from-children
#18
Maria Isabel Cunha Vieira Cordioli, Lais Moraes, André Uchimura Bastos, Paloma Besson, Maria Teresa de Seixas Alves, Rosana Delcelo, Osmar Monte, Carlos A Longui, Adriano Namo Cury, Janete Cerutti
BACKGROUND: Previous studies reported significant differences in the clinical presentation and outcomes of papillary thyroid carcinoma (PTC) in pediatric patients compared to adults. Previous studies have suggested that the clinicopathological differences observed between pediatric and adult PTC may be due the existence of distinct genetic alterations. However, the knowledge of genetic events in pediatric PTC is based primarily on studies in radiation-exposed PTC or in few studies that enrolled predominantly adolescent patients...
November 16, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27849441/correction-to-thyroid-2013-23-360-370
#19
(no author information available yet)
No abstract text is available yet for this article.
November 16, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27849438/correction-to-thyroid-2014-24-1080-1087
#20
(no author information available yet)
No abstract text is available yet for this article.
November 16, 2016: Thyroid: Official Journal of the American Thyroid Association
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