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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/28741453/no-effect-of-levothyroxine-and-levothyroxine-induced-subclinical-thyrotoxicosis-on-the-pharmacokinetics-of-sorafenib-in-healthy-male-subjects
#1
Funan Huang, Antoinette Ajavon-Hartmann, Erya Huang, John Lettieri, Rong Liu, Carol Pena, Matthias Berse
<b>Background</b>: Patients receiving the multikinase inhibitor sorafenib for locally recurrent or metastatic, progressive, differentiated thyroid carcinoma (DTC) refractory to radioactive iodine often receive concomitant levothyroxine for thyroid-stimulating hormone (TSH) suppression. In the phase 3 DTC trial (DECISION), sorafenib exposure was ~2-fold higher than that observed in other cancers. We assessed sorafenib pharmacokinetics without and with concomitant levothyroxine to examine whether a levothyroxine interaction or levothyroxine-induced subclinical thyrotoxicosis results in increased sorafenib exposure in DTC patients...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741452/young-age-and-male-sex-can-predict-for-a-large-volume-central-neck-lymph-node-metastasis-in-clinical-n0-papillary-thyroid-microcarcinoma
#2
Hye-Seon Oh, Suyeon Park, Mijin Kim, Hyemi Kwon, Eyun Song, Tae-Yon Sung, Yu-Mi Lee, Won Gu Kim, Tae Yong Kim, YoungKee Shong, Won Bae Kim, MinJi Jeon
<b><i>Background</i></b> Large-volume lymph node metastasis (LNM) is associated with poor clinical outcomes in papillary thyroid microcarcinoma (PTMC) patients. However, sensitivity in the detection of central neck LNM on preoperative neck ultrasonography (US) is believed to be low. The aim of this study is to investigate the preoperative clinical factors associated with large volume LNM in clinical N0 PTMC patients. <b><i>Methods</i></b> In all, 2329 clinical N0 PTMC patients who underwent total thyroidectomy with prophylactic central lymph node (LN) dissection were evaluated...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741442/a-systematic-review-of-the-methods-of-diagnostic-accuracy-studies-of-the-afirma%C3%A2-gene-expression-classifier
#3
Quan-Yang Duh, Naifa Busaidy, Catherine Rahilly-Tierney, Hossein Gharib, Gregory W Randolph
BACKGROUND: The Afirma® Gene Expression Classifier (GEC) risk-stratifies Bethesda System for the Reporting of Thyroid Cytopathology class III/IV (indeterminate) thyroid nodules (ITNs) as Suspicious for malignancy or Benign. Several authors have published studies describing the diagnostic accuracy of the GEC. However, the quality of these methods has not been rigorously examined. SUMMARY: We searched Medline and EMBASE for studies published between January 1, 2010 and June 30, 2016 examining the sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) of the GEC...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28635571/comparison-of-the-seventh-and-eighth-editions-of-the-american-joint-committee-on-cancer-union-for-international-cancer-control-tumor-node-metastasis-staging-system-for-differentiated-thyroid-cancer
#4
Mijin Kim, Won Gu Kim, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Dong Eun Song, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Tae-Yon Sung, Min Ji Jeon
OBJECTIVE: To evaluate the efficacy and prognostic validity for disease-specific survival (DSS) of the eighth edition American Joint Committee on Cancer/Union for International Cancer Control tumor-node-metastasis (TNM) staging system (TNM-8) compared to the seventh edition (TNM-7) in patients with differentiated thyroid carcinoma (DTC). METHODS: The seventh and eighth editions of the TNM staging system were applied to 1613 DTC patients who underwent thyroid surgery between 1996 and 2003...
July 24, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28635560/sorafenib-in-japanese-patients-with-locally-advanced-or-metastatic-medullary-thyroid-carcinoma-and-anaplastic-thyroid-carcinoma
#5
Yasuhiro Ito, Naoyoshi Onoda, Ken-Ichi Ito, Iwao Sugitani, Shunji Takahashi, Iku Yamaguchi, Koki Kabu, Katsuya Tsukada
BACKGROUND: Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan, even though vandetanib for MTC and lenvatinib for MTC and ATC have been approved. Sorafenib is an oral multikinase inhibitor approved for the treatment of patients with radioactive iodine-refractory differentiated thyroid cancer (DTC). An uncontrolled, open-label, multicenter, single-arm, Phase 2 clinical study was conducted to evaluate the safety and efficacy of sorafenib in Japanese patients with MTC and ATC...
July 24, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614993/a-single-10%C3%A2-mg-oral-dose-of-biotin-interferes-with-thyroid-function-tests
#6
Rosa Paula M Biscolla, Maria Izabel Chiamolera, Ina Kanashiro, Rui M B Maciel, Jose G H Vieira
No abstract text is available yet for this article.
July 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28657510/results-of-screening-in-familial-non-medullary-thyroid-cancer
#7
Joanna Klubo-Gwiezdzinska, Lily Yang, Roxanne Merkel, Dhaval Patel, Naris Nilubol, Maria J Merino, Monica Skarulis, Samira M Sadowski, Electron Kebebew
BACKGROUND: Although a family history of thyroid cancer is one of the main risk factors for thyroid cancer, the benefit of screening individuals with a family history of thyroid cancer is not known. METHODS: A prospective cohort study was performed with yearly screening using neck ultrasound and fine-needle aspiration biopsy of thyroid nodule(s) >0.5 cm in at-risk individuals whose relatives were diagnosed with familial non-medullary thyroid cancer (FNMTC)...
July 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28657511/validation-of-american-thyroid-association-ultrasound-risk-assessment-of-thyroid-nodules-selected-for-ultrasound-fine-needle-aspiration
#8
Alice L Tang, Mercedes Falciglia, Huaitao Yang, Jonathan R Mark, David L Steward
OBJECTIVE: The aim of this study was to validate the American Thyroid Association (ATA) sonographic risk assessment of thyroid nodules. METHODS: The ATA sonographic risk assessment was prospectively applied to 206 thyroid nodules selected for ultrasound-guided fine-needle aspiration (US-FNA), and analyzed with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), as well as surgical pathology for the subset undergoing surgical excision. RESULTS: The analysis included 206 thyroid nodules averaging 2...
July 18, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28657477/re-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum-by-alexander-et-al-thyroid-2017-27-315-389
#9
Panagiotis Anagnostis, Eleftheria Lefkou, Dimitrios G Goulis
No abstract text is available yet for this article.
July 18, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28599610/re-thyroglobulin-as-a-functional-biomarker-of-iodine-status-in-a-cohort-study-of-pregnant-women-in-the-united-kingdom-by-bath-et-al-thyroid-2017-27-426-433
#10
Eftychia G Koukkou, Kostas B Markou
No abstract text is available yet for this article.
July 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28712348/an-exploratory-study-of-fatigue-and-physical-activity-in-canadian-thyroid-cancer-patients
#11
Ahmad Alhashemi, Jennifer Jones, David P Goldstein, Daniel Santa Mina, Lehana Thabane, Catherine Sabiston, Eugene K Chang, James Brierley, Anna M Sawka
BACKGROUND: Fatigue is common among cancer survivors, but fatigue in thyroid cancer (TC) survivors may be underappreciated. We investigated the severity and prevalence of moderate and severe fatigue in TC survivors. Potential predictive factors, including physical activity, were explored. METHODS: We performed a cross-sectional, written, self-administered TC patient survey and retrospective chart review in an outpatient academic Endocrinology clinic in Toronto, Canada...
July 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614983/second-primary-cancer-in-patients-with-differentiated-thyroid-cancer-does-radioiodine-play-a-role
#12
Margarida Silva-Vieira, Sofia Carrilho Vaz, Susana Esteves, Teresa C Ferreira, Edward Limbert, Lucília Salgado, Valeriano Leite
BACKGROUND: Well-differentiated thyroid cancer (WDTC) is the most common endocrine neoplasia, and its incidence is rising. Studies have reported an increased risk of second primary cancer (SPC) in WDTC survivors, but its relationship with radioiodine treatment (RAIT) and other risk factors remains controversial. This study evaluated whether RAIT is an independent risk factor for SPC in WDTC patients. METHODS: This was a retrospective single-center study. A total of 2031 patients with WDTC diagnosed between 1998 and 2009, treated and followed at the authors' tertiary cancer center, were included...
July 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699478/long-term-antithyroid-drug-treatment-a-systematic-review-and-meta-analysis
#13
Fereidoun Azizi, Ramin Malboosbaf
BACKGROUND: Several studies have reported inconsistent findings on the advantages and disadvantages of Long-term treatment with antithyroid drugs (ATD). We undertook a systematic review and meta-analysis to clarify the numerous aspects of Long-term treatment with ATD. METHODS: Medline and the Cochrane Library for trials published between 1950 and May 2016 were systematically searched. We included studies containing data for Long-term (> 24 months) ATD treatment...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699428/thyroid-stimulating-hormone-suppressive-therapy-for-low-risk-small-thyroid-cancer-a-propensity-score-matched-cohort-study
#14
Suyeon Park, Won Gu Kim, Minkyu Han, MinJi Jeon, Hyemi Kwon, Mijin Kim, Tae-Yon Sung, Tae Yong Kim, Won Bae Kim, Suck Joon Hong, YoungKee Shong
BACKGROUND: Thyroid-stimulating hormone (TSH) suppression has improved the clinical outcomes of patients with differentiated thyroid cancer (DTC). However, the efficacy of TSH suppressive therapy (TST) is unclear in patients with low-risk DTC. We aimed to evaluate the efficacy of TST and optimal TSH levels of patients with low-risk DTC. METHODS: The retrospective propensity-score matched cohort study included DTC patients (n = 446) who underwent lobectomy from 2002 to 2008 with or without TST (TST group and No-TST group)...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699427/treatment-of-swedish-patients-with-graves-hyperthyroidism-is-associated-with-changes-in-acylcarnitine-levels
#15
Mahmoud Al-Majdoub, Mikael Lantz, Peter Spègel
Background Hyperthyroidism is associated with alterations in metabolism that currently are only partially understood. The objective of the study was to investigate changes in metabolism associated with reinstatement of euthyroidism in Swedish patients. Methods We profiled 80 metabolites in plasma from 10 subjects with Graves' disease at baseline and after 9 and 15 month of treatment to reinstate euthyroidism. Thyroid parameters, thyroid stimulating hormone (TSH), TSH receptor antibodies, free T3 and T4 were followed...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699420/referral-trends-for-surgical-management-of-graves-disease
#16
Warren C Swegal, Steven S Chang, Michael C Singer
BACKGROUND: Treatment algorithms for Graves' disease (GD) differ internationally and frequency of referral for surgical intervention varies markedly between areas. Given the potential benefits of thyroidectomy over radioactive iodine (RAI) and medical therapy, surgery may be underutilized. To better understand the approach of endocrinologists to GD, we assessed the rationale for consultation among patients referred for thyroidectomy to an endocrine surgery practice in the United States...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699414/role-of-ultrasound-in-predicting-tumor-invasiveness-in-follicular-variant-of-papillary-thyroid-carcinoma
#17
Soo Yeon Hahn, Jung Hee Shin, Young Lyun Oh, Tae Hyuk Kim, Yaeji Lim, Ji Soo Choi
BACKGROUND: Follicular variant of papillary thyroid carcinoma (FVPTC) is traditionally divided into infiltrative and encapsulated types. Adding to this classification, noninvasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP) represents a reclassification of a subset of cases (encapsulated tumors without lymphovascular or capsular invasion). The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in FVPTC. METHODS: From January 2014 to May 2016, preoperative US examinations were performed on 151 patients with 152 FVPTCs who underwent surgery...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699391/anti-pd-1-antibody-therapy-induces-hashimoto-s-disease-with-increase-in-peripheral-blood-follicular-helper-t-cells
#18
Keiichi Torimoto, Yosuke Okada, Shingo Nakayamada, Satoshi Kubo, Yoshiya Tanaka
Not Applicable.
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28605984/is-the-intrinsic-genomic-activity-of-thyroxine-relevant-in-vivo-effects-on-gene-expression-in-primary-cerebrocortical-and-neuroblastoma-cells
#19
Pilar Gil-Ibáñez, Mónica M Belinchón, Beatriz Morte, Maria Jesus Obregón, Juan Bernal
BACKGROUND: The possibility that the intrinsic genomic activity of thyroxine (T4) is of physiological relevance has been frequently hypothesized. It might explain gene expression patterns in the brain found in type 2-deiodinase (Dio2)-deficient mice. These mice display normal expression of most thyroid hormone-dependent genes, despite decreased brain triiodothyronine (T3). METHODS: The relative effects of T4 and T3 on gene expression were analyzed in mouse neuro-2a (N2a) cells stably expressing the thyroid hormone receptor α1, and in primary mouse cerebrocortical cells enriched in astrocytes or in neurons...
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614984/tert-promoter-mutations-were-not-found-in-papillary-thyroid-microcarcinomas-that-showed-disease-progression-on-active-surveillance
#20
Tomonori Yabuta, Michiko Matsuse, Mitsuyoshi Hirokawa, Shunichi Yamashita, Norisato Mitsutake, Akira Miyauchi
No abstract text is available yet for this article.
July 11, 2017: Thyroid: Official Journal of the American Thyroid Association
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