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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/30221579/circulating-epithelial-cell-characterization-and-correlation-with-remission-and-survival-in-patients-with-thyroid-cancer
#1
Jen-Der Lin, Miaw-Jene Liou, Hsung-Ling Hsu, Kong-Kit Leong, Yu-Ting Chen, Ying-Ru Wang, Wei-Shan Hung, Hsing-Ying Lee, Hui-Ju Tsai, Ching-Ping Tseng
<b><i>Background</i></b>: Thyroid cancer is the most common endocrine tumor and generally has relatively good clinical outcomes. However, 15-20% of patients ultimately develop recurrence or disease-related death. The appropriate prognostic factors for thyroid cancer are still elusive. This study evaluated whether the number of circulating tumor cells/circulating epithelial cells (CECs) expressing either epithelial cell adhesion molecule (EpCAM), podoplanin (PDPN), or thyroid-stimulating hormone receptor (TSHR) is related to remission and disease-specific mortality (DSM) of patients with thyroid cancer...
September 15, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30215297/oncocytic-papillary-thyroid-cancer-has-similar-prognosis-to-matched-classical-papillary-thyroid-cancer-controls
#2
Azadeh A Carr, Tina Yen, Diana I Ortiz, Bryan C Hunt, Gilbert Fareau, Becky L Massey, Bruce H Campbell, Kara L Doffek, Douglas B Evans, Tracy S Wang
BACKGROUND: Previous studies have suggested that oncocytic variant papillary thyroid cancer (PTC) may be more aggressive, with higher rates of recurrent disease. The aim of this study was to evaluate characteristics and outcomes of patients with oncocytic variant PTC compared to classical PTC. METHODS: Patients with oncocytic variant PTC were retrospectively identified from 519 patients who underwent thyroidectomy for PTC between 1/09-8/15. Data collected included patient demographics, laboratory and pathology findings, imaging studies, treatment, and follow-up...
September 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30084742/developing-a-clinical-prototype-to-guide-surgeons-for-intraoperative-label-free-identification-of-parathyroid-glands-in-real-time
#3
Giju Thomas, Melanie A McWade, Constantine Paras, Emmanuel A Mannoh, Melinda E Sanders, Lisa M White, James T Broome, John E Phay, Naira Baregamian, Carmen C Solórzano, Anita Mahadevan-Jansen
BACKGROUND: Patients undergoing thyroidectomy may have inadvertent damage or removal of the parathyroid gland(s) due to difficulty in real-time parathyroid identification. Near-infrared autofluorescence (NIRAF) has been demonstrated as a label-free modality for intraoperative parathyroid identification with high accuracy. This study presents the translation of that approach into a user-friendly clinical prototype for rapid intraoperative guidance in parathyroid identification. METHODS: A laboratory (lab)-built spectroscopy system that measures NIRAF in tissue was evaluated for identifying parathyroid glands in vivo across 162 patients undergoing thyroidectomy and/or parathyroidectomy...
September 11, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30141375/88-th-annual-meeting-of-the-american-thyroid-association-october-3-7-2018-marriott-marquis-washington-dc
#4
Mabel Ryder, Greg Randolph
No abstract text is available yet for this article.
September 7, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30084737/association-between-primary-hypothyroidism-and-nonalcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#5
Alessandro Mantovani, Fabio Nascimbeni, Amedeo Lonardo, Giacomo Zoppini, Enzo Bonora, Christos S Mantzoros, Giovanni Targher
BACKGROUND: It is currently uncertain whether primary hypothyroidism is associated with nonalcoholic fatty liver disease (NAFLD). We performed a meta-analysis of relevant studies to quantify the magnitude of association between primary hypothyroidism and risk of NAFLD. METHODS: We searched PubMed, Web of Science and Scopus databases from January 2000 to March 2018 using predefined keywords to identify observational cross-sectional, case-control, and longitudinal studies in which NAFLD was diagnosed by imaging or biopsy...
August 30, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30156472/the-effects-of-radioactive-iodine-therapy-on-ovarian-reserve-a-prospective-pilot-study
#6
Berna Evranos, Sevgul Faki, Sefika Burcak Polat, Nagihan Bestepe, Reyhan Ünlü Ersoy, Bekir Cakir
INTRODUCTION: Thyroid carcinoma is the most common endocrine malignancy. Surgery is the standard therapeutic approach for patients with differentiated thyroid carcinoma (DTC), followed by radioiodine (RAI) therapy (if needed). For women with DTC, the effects of RAI therapy on gonadal and reproductive function are an important consideration. We aimed to evaluate the effects of RAI therapy on ovarian function. MATERIALS AND METHODS: A total of 33 premenopausal women were enrolled in this study...
August 29, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30142994/anlotinib-for-the-treatment-of-patients-with-locally-advanced-or-metastatic-medullary-thyroid-cancer
#7
Yongkun Sun, Feng Du, Ming Gao, Qing-Hai Ji, Zhendong Li, Yuan Zhang, Zhuming Guo, Jun Wang, Xiangjin Chen, Jinwan Wang, Yihebali Chi, Ping Zhang Tang
BACKGROUND: the prognosis of advanced or metastatic medullary thyroid carcinoma (MTC) is poor and there are few therapeutic options. Anlotinib has previously shown promising antitumor activity on MTC in preclinical models and phase I study. This phase II clinical trial was devised to confirm the anti-tumor activity of anlotinib in patients with advanced or metastatic MTC. METHODS: Patients with unresectable locally advanced or metastatic MTC received once daily oral anlotinib 12 mg, 2 weeks on/ 1 week off, until disease progression, death, unacceptable toxicity or withdrawal of consent for any reason...
August 24, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30141373/survival-in-differentiated-thyroid-cancer-comparing-the-ajcc-cancer-staging-7th-and-8th-editions
#8
Samantha Tam, Mongkol Boonsripitayanon, Moran Amit, Bryan M Fellman, Yisheng Li, Naifa Busaidy, Maria Cabanillas, Ramona Dadu, Steven I Sherman, Steven G Waguespack, Michelle D Williams, Ryan P Goepfert, Neil D Gross, Nancy Perrier, Erich Sturgis, Mark Zafereo
BACKGROUND: The AJCC Cancer Staging for differentiated thyroid cancer (DTC) has been recently revised. The purpose of this study was to compare survival prognostication between the 7th and 8th editions. MATERIALS & METHODS: We retrospectively reviewed 2,579 DTC patients who underwent surgery at MD Anderson Cancer Center between 2000 and 2015. Disease-specific survival (DSS) and overall survival (OS) were estimated using the Kaplan-Meier method and compared using log rank test...
August 24, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30027832/transcutaneous-recording-during-intraoperative-neuromonitoring-in-thyroid-surgery
#9
Che-Wei Wu, Feng-Yu Chiang, Gregory W Randolph, Gianlorenzo Dionigi, Hoon Yub Kim, Yi-Chu Lin, Tzu-Yen Huang, Chiao-I Lin, Pao-Chu Hun, Dipti Kamani, Pi-Ying Chang, I-Cheng Lu
BACKGROUND: Recurrent laryngeal nerve (RLN) palsy remains a major source of morbidity after thyroid surgeries. Intraoperative neural monitoring (IONM) has gained increasing acceptance as an adjunct to standard practice of visual RLN identification. Endotracheal tube (ETT) surface recording electrodes systems are now widely used for IONM; however, a malpositioned ETT can cause false IONM results and requires time-consuming intraoperative verification of the ETT position and readjustment by the anesthesiologist...
August 24, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30132420/iodine-intake-is-associated-with-thyroid-function-in-mild-to-moderately-iodine-deficient-pregnant-women
#10
Marianne Hope Abel, Tim Korevaar, Iris Erlund, Gro Dehli Villanger, Ida Henriette Caspersen, Petra Arohonka, Jan Alexander, Helle Margrete Meltzer, Anne Lise Brantsaeter
BACKGROUND: Studies indicate that mild- to moderate iodine deficiency in pregnancy may have long-term negative impact on child neurodevelopment. These effects are likely mediated via changes in maternal thyroid function since iodine is essential for the production of thyroid hormones. However, the impact of iodine availability on thyroid function during pregnancy and on thyroid function reference ranges are understudied. The aim of this study was to investigate the association between iodine intake and thyroid function during pregnancy...
August 22, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30132418/patients-with-indeterminate-thyroid-nodules-at-cytology-and-cancer-at-histology-have-a-more-favourable-outcome-with-respect-to-patients-with-suspicious-or-malignant-cytology
#11
Teresa Rago, Maria Scutari, Valeria Loiacono, Massimo Tonacchera, Giuditta Scuotri, Rossana Romani, Agnese Proietti, Paolo Piaggi, Rossella Elisei, Fulvio Basolo, Francesco Latrofa, Paolo Vitti
BACKGROUND: The outcome of thyroid cancer proven at histology in patients in whom cytology was Thy 3 (indeterminate; Thy 3 patients) based on the Italian consensus classification compared to those in whom cytology was Thy 4 (suspicious for malignancy) or Thy 5 (indicative for malignancy) (Thy 4-5 patients) remains unclear. OBJECTIVE: To analyze the outcome of 371 Thy 3 patients vs 269 Thy 4-5 patients homogeneously treated with total thyroidectomy and 131-I activity...
August 22, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30132411/deep-learning-based-computer-aided-diagnosis-system-for-localization-and-diagnosis-of-metastatic-lymph-nodes-on-ultrasound-a-pilot-study
#12
Jeong Hoon Lee, Jung Hwan Baek, Ju Han Kim, Woo Shim, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
BACKGROUND: The presence of metastatic lymph nodes is a prognostic indicator of the patient and is an important determinant of clinical decision making. However, this process requires experience and is labor-intensive because many lymph nodes are located in the neck. Therefore, the development of a computer-aided diagnosis (CAD) system to identify and differentiate metastatic lymph nodes is may be useful. METHODS: From January 2008 to December 2016, we retrieved clinical records for 804 consecutive patients with 812 lymph nodes...
August 22, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30132406/hyperthyroidism-and-papillary-thyroid-carcinoma-in-thyrotropin-receptor-d633h-mutant-mice
#13
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, Jukka Kero
BACKGROUND: Constitutively active thyrotropin receptor (TSHR) mutations are the most common etiology of non-autoimmune hyperthyroidism (NAH). Thus far, the functionality of these mutations has been tested <i>in vitro</i>, but the <i>in vivo</i> models are lacking. METHODS: To understand the pathophysiology of NAH, we introduced the patient-derived constitutively active TSHR D633H mutation into the murine <i>Tshr</i> by homologous recombination...
August 22, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30132401/immune-checkpoint-inhibitor-mediated-thyroiditis
#14
Priyanka C Iyer, Maria Cabanillas, Steven G Waguespack, Mimi I Hu, Sonali N Thosani, Victor R Lavis, Naifa Busaidy, Sumit K Subudhi, Adi Diab, Ramona Dadu
BACKGROUND: Although immune-related thyroiditis (irT) with immune checkpoint inhibitors (ICI) is a common consequence, its natural course and management recommendations are not well characterized in existing guidelines. We sought to study the evolution of irT and describe its course and sequelae. METHODS: Retrospective study of cancer patients treated with ICI between 11/2014 and 07/2016 at MD Anderson Cancer Center and referred for endocrinology evaluation for suspected irT...
August 22, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30129898/diagnostic-performance-of-tc-99m-mibi-for-differentiation-of-malignant-thyroid-nodules-a-systematic-review-and-meta-analysis
#15
Seong-Jang Kim, Sang-Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim
OBJECTIVE: The purpose of the current study was to investigate the diagnostic performance of Tc-99m methoxy-isobutyl-isonitrile (MIBI) for differentiation of malignant thyroid nodules (TN) through a systematic review and meta-analysis. METHODS: The MEDLINE/PubMed and EMBASE database, from the earliest available date of indexing through January 31, 2018, were searched for studies evaluating the diagnostic performance of Tc-99m MIBI for TN. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic curves...
August 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30129889/dynamic-risk-stratification-in-the-follow-up-of-children-and-adolescents-with-differentiated-thyroid-cancer
#16
André B Zanella, Rafael Selbach Scheffel, Carla Fernanda Nava, Lenara Golbert, Erika Laurini de Souza Meyer, Márcia Puñales, Iracema Gonçalves, José Miguel Dora, Ana Luiza Maia
BACKGROUND: Risk stratification for persistent disease is an important step in pediatric differentiated thyroid cancer (DTC) management. The dynamic risk stratification (DRS) is a well validated system for adults, but not yet for children and adolescents. Here, we evaluated the DRS as well as other prognostic factors in pediatric DTC. METHODS: Patients aged ≤ 18 years from 4 DTC tertiary teaching hospitals in Southern Brazil were included. Clinical characteristics were systematically retrieved, and all patients were classified according to risk stratification system of the 2015 ATA Children DTC guidelines (ATA Risk) and according to DRS (excellent, indeterminate, biochemical, or structural incomplete responses)...
August 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30129879/anticonvulsant-and-neuroprotective-effects-of-the-thyroid-hormone-metabolite-3-iodothyroacetic-acid-ta1
#17
Annunziatina Laurino, Elisa Landucci, Francesco Resta, Gaetano De Siena, Domenico Edoardo Pellegrini-Giampietro, Alessio Masi, Guido Mannaioni, Laura Raimondi
Background 3-iodothyroacetic acid (TA1) is among thyroid hormone (T3) end metabolites acutely modifying mice behavior. We aimed to investigate whether TA1 was also able to reduce neuron hyper-excitability and protect from excitotoxic damage. Methods CD1 male mice were treated i.p. with saline solution or TA1 (4, 7, 11, or 33 μg‧kg-1) before receiving s.c. 90 mg‧kg<sup>-1 </sup>pentylenetrazole (PTZ). The following parameters were measured: latency to first seizure onset, number of mice experiencing seizures, hippocampal levels of c-fos and IP3/AKT activation levels...
August 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30039751/follicular-thyroid-carcinoma-a-perspective
#18
Gilbert H Daniels
No abstract text is available yet for this article.
August 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30039748/patients-with-benign-thyroid-diseases-experience-and-impaired-sex-life
#19
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Laszlo Hegedüs, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, Torquil Watt
BACKGROUND: This study aimed to characterize the frequency of self-reported thyroid-related impaired sex life in patients with thyroid diseases, to examine its clinical correlates and relationship with overall quality of life (QOL), and to investigate the effect of treatment. PATIENTS AND METHODS: Two separate patient samples with benign thyroid diseases were investigated: a cross-sectional sample (759 women and 118 men) treated at two Danish university hospital outpatient clinics, in 2007-2008, and a longitudinal sample (358 women and 74 men) undergoing treatment at the abovementioned centers, during 2008-2012, evaluated before and 6 months after therapy...
August 21, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/30105948/intermediate-risk-papillary-thyroid-cancer-risk-factors-for-early-recurrence-in-patients-with-excellent-response-to-initial-therapy
#20
Augusto Llamas-Olier, Diana Isabel Cuéllar, Giancarlo Buitrago
BACKGROUND: Patients with excellent response to initial therapy have a low rate of tumor recurrence. The objective of this study was to evaluate the rate of early tumor recurrence in patients with intermediate- risk papillary thyroid cancer who had an excellent response to initial treatment and identify risk factors. METHODS: This retrospective cohort study included 217 patients with American Thyroid Association (ATA) intermediate-risk papillary thyroid cancer who had a documented excellent response to initial treatment (total thyroidectomy and adjuvant therapy with 100 -150 mCi [3...
August 14, 2018: Thyroid: Official Journal of the American Thyroid Association
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