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Thyroid: Official Journal of the American Thyroid Association

Jessa E Miller, Neal C Al-Attar, Owen H Brown, Gabrielle G Shaughness, Natalja P Rosculet, Anca Avram, David T Hughes
BACKGROUND: After initial surgical treatment of differentiated thyroid cancer (DTC) residual lymph node metastases are often found at the time of radioactive iodine (131-I) therapy. Recurrence of DTC is due to persistent disease not removed at initial surgery and that did not respond to 131-I treatment. This study aims to determine locations of, and reasons for, residual nodal metastases detected by 131-I scans with SPECT/CT obtained prior to radioiodine therapy following surgical treatment of DTC...
March 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Songchang Chen, Shuyuan Li, Junyu Zhang, Lanlan Zhang, Yiyao Chen, Li Wang, Li Jin, Yuting Hu, Xiaoping Qi, Hefeng Huang, Chenming Xu
BACKGROUND: The revised guidelines for the management of medullary thyroid carcinoma recommend that genetic counseling regarding reproductive options, including preimplantation genetic diagnosis (PGD), be considered for all RET mutation carriers of reproductive age to avoid the transmission of multiple endocrine neoplasia type 2 (MEN2). However, the high complexity and cost of PGD have hindered its widespread use. Thus, it is necessary to establish a simple and relatively inexpensive method to facilitate the PGD of MEN2...
March 1, 2018: Thyroid: Official Journal of the American Thyroid Association
Harald Dobnig, Karin Amrein
Background Monopolar radiofrequency ablation is currently deemed an exotic treatment option for benign thyroid nodules in many central European countries. The aim of this study was to prospectively evaluate safety and efficacy of this method in a large patient cohort following its introduction in Austria. Patients and methods Peri- and post-interventional complications were analyzed for 277 patients. Efficacy was determined for 300 and 154 nodules at, respectively, 3 and 12 months post-treatment. All treatments were performed with an internally-cooled 18G radiofrequency electrode using a free-hand, so-called "moving-shot" technique following subcutaneous and local perithyroidal anesthesia...
February 28, 2018: Thyroid: Official Journal of the American Thyroid Association
Carrie C Lubitz, Tiannan Zhan, Viswanath Gunda, Salma Amin, Benjamin J Gigliotti, Abbey L Fingeret, Tammy M Holm, Heather Wachtel, Peter M Sadow, Lori J Wirth, Ryan J Sullivan, David J Panka, Sareh Parangi
BACKGROUND: BRAFV600E is the most common mutation in papillary thyroid carcinoma (PTC) and can be associated with aggressive disease. Previously, a highly sensitive blood RNA-based BRAFV600E assay was reported. The objective of this study was to assess the correlation of BRAFV600E circulating tumor RNA levels with surgical and medical treatment. METHODS: Circulating BRAFV600E levels were assessed in (i) a murine model of undifferentiated (anaplastic) thyroid carcinoma with known BRAFV600E mutation undergoing BRAFV600E -inhibitor (BRAFi) treatment, and (ii) in 111 patients enrolled prior to thyroidectomy (n = 86) or treatment of advanced recurrent or metastatic PTC (n = 25)...
February 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Iris Yaish, Foad Azem, Orit Gutfeld, Zmira Silman, Merav Serebro, Orli Sharon, Gabi Shefer, Rona Limor, Naftali Stern, Karen M Tordjman
BACKGROUND: Women of reproductive age with differentiated thyroid cancer (DTC) often need to receive radioactive iodine (RAI) treatment after surgery. In contrast to the well documented effect of RAI on testicular function, the potential negative effects of this treatment on ovarian reserve have been largely dismissed. The objective of this pilot study was to examine the possibility that RAI treatment is deleterious to the ovarian reserve by prospectively measuring the concentration of anti-Müllerian hormone (AMH) after this treatment...
February 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Marra Aghajani, Susannah Graham, Charles McCafferty, Christina Abdel Shaheed, Tara Roberts, Paul DeSouza, Tao Yang, Navin Niles
BACKGROUND: Evidence has shown that PD-L1 overexpression is associated with poor prognosis and resistance to immune therapies in several human cancers. However, data on the prognostic significance of PD-L1 expression in thyroid cancer is limited and remains controversial. In this systematic review and meta-analysis, we aimed to comprehensively evaluate the clinicopathological significance and prognostic value of PD-L1 expression in non-medullary thyroid cancers. SUMMARY: Electronic databases, including Medline/PubMed, EMBASE and the Cochrane Library, were searched up until July 5th, 2017...
February 17, 2018: Thyroid: Official Journal of the American Thyroid Association
Min Joo Kim, Jae-Kyung Won, Kyeong Cheon Jung, Ji-Hoon Kim, Sun Wook Cho, Do Joon Park, Young Joo Park
BACKGROUND: Among follicular variant papillary thyroid carcinomas (FVPTCs), the noninvasive encapsulated subtype has an excellent prognosis. For this reason, reclassification of noninvasive encapsulated FVPTC (EFVPTC) as a new entity called "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) has been proposed, but controversy remains. To characterize noninvasive EFVPTC in an Asian population, the clinicopathologic features of each FVPTC subtype were compared in a Korean population...
February 16, 2018: Thyroid: Official Journal of the American Thyroid Association
Hye-Seon Oh, Hyemi Kwon, Eyun Song, Min Ji Jeon, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Suck Joon Hong, Won Bae Kim, Young Kee Shong, Jung Hwan Baek, Won Gu Kim
BACKGROUND: Total thyroidectomy and cervical lymph node (LN) dissection is generally recommended in patients with medullary thyroid carcinoma (MTC). However, there is no clear evidence for whom to perform prophylactic lateral neck dissection in MTC patients without evident lateral cervical lymph node (LCLN) metastasis in preoperative images. This study evaluated the preoperative features for predicting the LCLN metastasis of MTC. METHODS: The study included 26 MTC patients with LCLN metastasis at initial surgery (N1b group) and 47 MTC patients without any LN metastasis or recurrence of disease (N0-NED group)...
February 15, 2018: Thyroid: Official Journal of the American Thyroid Association
Francesco Latrofa, Debora Ricci, Sara Bottai, Federica Brozzi, Luca Chiovato, Paolo Piaggi, Michele Marino, Paolo Vitti
BACKGROUND: To establish whether thyroglobulin autoantibodies (TgAb) influence the metabolic clearance of thyroglobulin (Tg) in humans, we correlated serum Tg and TgAb shortly after 131I treatment. METHODS: Samples were collected from 30 consecutive patients undergoing 131I activity for Graves' hyperthyroidism at the time of treatment and every 15 days thereafter, up to 90 days. Tg and TgAb were measured by immunometric assays (functional sensitivities: 0.1 ng/mL and 8 IU/mL)...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Sarah H Nash, Anne P Lanier, Molly B Southworth
BACKGROUND: Nationwide, the incidence of thyroid cancer is lower among American Indian/Alaska Native (AI/AN) people than among U.S. whites (USW). However, little is known about the incidence of thyroid, or other endocrine cancers specifically among Alaska Native (AN) people. METHODS: We examined data from the National Cancer Institute's (NCI) Surveillance Epidemiology and End Results (SEER) Alaska Native Tumor Registry on endocrine cancers diagnosed among AN people from 1969-2013, with a specific focus on thyroid cancers...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Jianyong Lei, Jinjing Zhong, Zhihui Li, Tao Wei, Rixiang Gong, Jinqiang Zhu
BACKGROUND AND AIMS: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk. PATIENTS AND METHODS: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Mijin Kim, MinJi Jeon, Hye-Seon Oh, Suyeon Park, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Kyunggon Kim, Won Gu Kim, Dong Eun Song
BACKGROUND: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor previously known as non-invasive subtype of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC). The absence of <i>BRAF<sup>V600E</sup></i> mutations has been considered characteristic of NIFTPs. However, a recent study from Korea found that 28.6% of NIFTPs harbored a <i>BRAF</i> mutation. In this study, we evaluated <i>BRAF</i> and <i>RAS</i> mutations in NIFTPs and invasive subtype of EFVPTCs...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Kenichi Kawahori, Koshi Hashimoto, Xunmei Yuan, Kazutaka Tsujimoto, Nozomi Hanzawa, Miho Hamaguchi, Saori Kase, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Yasuyo Nakajima, Nobuyuki Shibusawa, Masanobu Yamada, Yoshihiro Ogawa
BACKGROUND: Thyroid hormones are essential for normal development of the central nervous system (CNS). Experimental rodents have shown that even a subtle thyroid hormone insufficiency in circulating maternal thyroid hormones during pregnancy may adversely affect neurodevelopment in offspring, resulting in irreversible cognitive deficits. This may be due to the persistent reduced expression of the hippocampal brain-derived neurotrophic factor gene (Bdnf), which plays a crucial role in CNS development...
February 7, 2018: Thyroid: Official Journal of the American Thyroid Association
Dania Hirsch, Orit Twito, Sigal Levy, Gideon Bachar, Eyal Robenshtok, David Gross, Haggi Mazeh, Carlos Benbassat, Simona Grozinsky-Glasberg
BACKGROUND: The widespread use of neck sonography in recent years has led to a dramatic increase in the detection of thyroid cancer, accompanied by changes in the clinicopathological features of the disease. However, small papillary carcinomas account for the bulk of this increase, while little is known about temporal changes in medullary thyroid carcinoma (MTC). The aim of this study was to evaluate trends in the presentation, treatment, and outcome of MTC. METHODS: Patients treated for MTC at four medical centers in Israel were divided into three groups by year of diagnosis: 1981-1995 (period A), 1996-2005 (period B), and 2006-2016 (period C)...
February 5, 2018: Thyroid: Official Journal of the American Thyroid Association
Ricardo Cortez Cardoso Penha, Simona Pellecchia, Roberto Pacelli, Luis Felipe Ribeiro Pinto, Alfredo Fusco
BACKGROUND: Ionizing Radiation (IR) is a well-known risk factor for papillary thyroid cancer, and it has been reported to deregulate microRNA expression, which is important to thyroid carcinogenesis. Therefore, we have investigated the impact of IR on microRNA expression profile of the normal thyroid cell line (FRTL-5 CL2) and as well as its effect on radiosensitivity of thyroid cancer cell lines, especially the human anaplastic thyroid carcinoma cell line (8505c). METHODS: The global microRNA expression profile of irradiated FRTL-5 CL2 cells (5 Gy X-ray) was characterized and data were confirmed by qRT-PCR evaluating the expression of rno-miR-10b-5p, rno-miR-33-5p, rno-miR-128-1-5p, rno-miR-199a-3p, rno-miR-296-5p, rno-miR-328a-3p and rno-miR-541-5p in irradiated cells...
February 3, 2018: Thyroid: Official Journal of the American Thyroid Association
Iman Jahanbani, Abeer Al-Abdallah, Rola Ali, Nabeel Al-Brahim, Olusegun Mojiminiyi
BACKGROUND: Papillary thyroid carcinoma (PTC) variants have several overlapping clinical and pathological features. The World Health Organization (WHO) published recently a new classification of thyroid tumors containing significant revisions. the encapsulated papillary thyroid carcinoma (EPTC) has been recognized as a distinctive variant of PTC. The noninvasive encapsulated follicular variant of PTC has been reclassified as "Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP)"...
January 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Xuan V Nguyen, Kingshuk Roy Choudhury, Franklin N Tessler, Jenny K Hoang
<b>Background: </b>In many risk-stratification systems, the decision to biopsy thyroid nodules is determined by their sonographic features and size. Nevertheless, even small, low-suspicion nodules are often biopsied because it is assumed that larger malignant nodules are associated with poorer outcomes. The aim of this study was to quantify the effect of thyroid cancer tumor size on survival and risk of T4 stage, nodal disease, and distant metastases. <b>Methods: </b>The Surveillance, Epidemiology, and End Results (SEER) 18 database was queried to obtain tumor size, staging information, and survival data for cases of differentiated thyroid cancer (DTC) and non-differentiated thyroid cancer reported between 2004 and 2014...
January 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Mijin Kim, Tae Hyuk Kim, Dong Yeob Shin, Dong-Jun Lim, Eui Young Kim, Won Bae Kim, Jae Hoon Chung, YoungKee Shong, Bo Hyun Kim, Won Gu Kim
BACKGROUND: Sorafenib, a multi-kinase inhibitor, is approved for the treatment of patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC). In this study, we evaluated the efficacy and safety of sorafenib in real-world clinical practice and compared the results with those of the DECISION trial. We also evaluated the clinical features associated with better clinical outcomes after sorafenib treatment. METHODS: This multicenter, retrospective cohort study evaluated 98 patients with progressive RAI-refractory DTC who were treated with sorafenib in six tertiary hospitals in Korea...
January 19, 2018: Thyroid: Official Journal of the American Thyroid Association
Xiao Yang, Yu Lun, Han Jiang, Xun Liu, Zhiquan Duan, Shijie Xin, Jian Zhang
BACKGROUND: Hashimoto's thyroiditis (HT) is an autoimmune thyroid disease characterized by low expression of transcription factor Forkhead Box P3 (FOXP3) and functional deficiency of a cluster of differentiation regulatory T cells (Tregs). This study aimed to investigate the mechanism of Treg dysfunction in HT. METHODS: The number of CD4+CD25+FOXP3+T cells was determined by flow cytometry. Expression of FOXP3 and Sirtuin type 1 (SIRT1) was evaluated by Western Blot analysis...
January 16, 2018: Thyroid: Official Journal of the American Thyroid Association
Georgios E Papadakis, Faiza Lamine, Haithem Chtioui, Eleni Moschouri, Monserrat Fraga Christinet, Laura Marino, Lucie Favre, Amedeo Sciarra, Christine Sempoux, Alexandra Schneider, Francois-Regis Duss, Claudio Sartori, Darius Moradpour, Gerasimos P Sykiotis
No abstract needed for a Letter to the Editor according to the journal's guidelines for Authors.
January 16, 2018: Thyroid: Official Journal of the American Thyroid Association
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