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Thyroid: Official Journal of the American Thyroid Association

Ayman J Oweida, Andy Phan, Benjamin Vancourt, Tyler Robin, Mohammad K Hararah, Shilpa Bhatia, Dallin Milner, Shelby Lennon, Laura Pike, David Raben, Bryan R Haugen, Nikita Pozdeyev, Rebecca E Schweppe, Sana D Karam
Anaplastic thyroid cancer is an aggressive and highly lethal disease with poor outcomes and resistance to therapy. Despite multimodality treatment including radiation therapy and chemotherapy, response rates remain below 15% with a median time to progression of less than 3 months. Recent advances in radiotherapy delivery and gene-expression profiling may help guide patient selection for personalized therapy. The purpose of this study was to characterize the response to radiation in a panel of ATC cell lines and to test alternative radiotherapy fractionation schedules for overcoming radioresistance...
May 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Huiling He, Wei Li, Pearlly Yan, Ralf Bundschuh, Jackson A Killian, Jadwiga Labanowska, Pamela Brock, Rulong Shen, Nyla A Heerema, Albert de la Chapelle
BACKGROUND: The BRAFV600E mutation is the most common driver in papillary thyroid carcinoma (PTC) tumors. In recent years, gene fusions have also been recognized as important drivers of cancer in PTC. Previous studies have suggested that thyroid tumors with fusion genes frequently display an aggressive course. These observations prompted further exploration of gene fusions in PTC tumors. The aim was to search for previously unrecognized gene fusions using thyroid tissue samples from PTC patients...
May 16, 2018: Thyroid: Official Journal of the American Thyroid Association
Akihiro Kaneko, Kiminori Kubo, Shuji Fukata, Nobutaka Inoue
Background Accidentally ingested foreign bodies usually pass spontaneously; therefore, nearly all patients remain asymptomatic. We report a case with destructive thyroiditis caused by ingested press-through-package (PTP) which remained at the entrance of the esophagus. Patient Findings A 78-year-old Japanese woman had slight fever and tenderness in her neck, and she was initially diagnosed with subacute thyroiditis. However, after careful medical history taking and conducting cervicothoracic computed tomography scanning, she was finally diagnosed with destructive thyroiditis caused by accidentally ingestion of PTP...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
Yui Watanabe, Reham Shareef Ebrhim, Mohamed A Abdullah, Roy E Weiss
Thyroid hormone synthesis requires the presence of iodide. The sodium iodide symporter (NIS) is a glycoprotein which mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). The proposita is a 28-year-old female whose origin is the North Sudan where neonatal screening for CH is not available. She presented with severe constipation and a goiter at the age of 40 days. Laboratory testing confirmed CH and she was started on levothyroxine (L-T4)...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
Sae Rom Chung, Young Jun Choi, Chong Hyun Suh, Hwa Jung Kim, Jong Jin Lee, Won Gu Kim, Tae-Yon Sung, Yu-Mi Lee, Dong Eun Song, Jeong Hyun Lee, Jung Hwan Baek
BACKGROUND: To stratify the risk of malignancy in thyroid incidentalomas detected on 18F-FDG PET/CT using ultrasound features according to guidelines for thyroid nodules and thereby suggests management plans. METHODS: From a historical cohort of 96 942 consecutive patients who underwent 18F-FDG PET/CT between October 2008 and September 2015, 1342 patients with 1364 nodules underwent ultrasound evaluation for focal uptake in thyroid gland, with a final diagnosis made for 877 patients with 907 nodules which included in our study...
May 15, 2018: Thyroid: Official Journal of the American Thyroid Association
Robert L Schmidt, Jonathan LoPresti, Michael T McDermott, Suzanna M Zick, Joely A Straseski
BACKGROUND: Clinical laboratories are under pressure to increase value by improving test utilization. The clinical utility of reverse triiodothyronine (rT3) is controversial. We conducted a study to identify order patterns that might suggest inappropriate utilization of reverse triiodothyronine. METHODS: We reviewed all orders for thyroid tests placed over a period of one year at a national reference laboratory. We analyzed order patterns by client (hospital) and by provider...
May 14, 2018: Thyroid: Official Journal of the American Thyroid Association
Karen P Chu, Sarah P Baker, Julianna K Zenke, Ahmed Morad, Sunita Ghosh, Don Morrish, Sandy McEwan, David C Williams, Diane Severin, Todd Patrick William McMullen
BACKGROUND: The application of radioactive iodine in differentiated thyroid carcinomas has become more selective in an attempt to decrease morbidity. While ablative success has been documented, it is less clear how changes in radioactive iodine treatment strategies will influence long-term recurrence rates for patients with larger tumours and adverse pathological features including extrathyroidal extension and nodal metastases. METHODS: Patients diagnosed between 1995-2008 with differentiated thyroid carcinoma treated with thyroidectomy followed by radioactive iodine treatment were eligible...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Jin Pyeong Kim, Jung Je Park, Seung Hoon Woo
BACKGROUND: No-scar transoral TGDC (thyroglossal duct cyst) excision is a newly developed treatment for TGDC, but limited information is available regarding the clinical outcomes in children. The aim of this study was to evaluate the safety, efficacy, and effects of transoral TGDC excision in children. METHODS: Forty-four children under 10 years of age received operative treatment for TGDC from January 2013 to December 2014, and follow-up was performed over 24 months...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Panos G Ziros, Ioannis Habeos, Dionysios V Chartoumpekis, Eleni Ntalampyra, Emmanuel Somm, Cédric O Renaud, Massimo Bongiovanni, Ioannis P Trougakos, Masayuki Yamamoto, Thomas W Kensler, Pilar Santisteban, Nancy Carrasco, Carrie Ris-Stalpers, Elena Amendola, Xiao-Hui Liao, Luciano Rossich, Lisa Thomasz, Guillermo Juan Juvenal, Samuel Refetoff, Gerasimos P Sykiotis
BACKGROUND: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation in order to maintain normal function. Although antioxidant and detoxification enzymes presumably aid thyroid cells to maintain homeostasis by ameliorating oxidative insults, including under conditions of exposure to excess iodide, the factors that coordinate their expression with the cellular redox status are not known...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
William Moss, Andrey Finegersh, John Pang, Joseph A Califano, Charles S Coffey, Ryan Orosco, Kevin T Brumund
BACKGROUND: Fine needle biopsy is the international standard for diagnostic evaluation of thyroid nodules. There is a lack of consensus regarding the optimal fine needle biopsy technique. The implementation of capillary action versus aspiration and the optimal needle gauge remain topics of debate. METHODS: A systematic review of the Medline, Embase and Cochrane databases was performed in accordance with PRISMA guidelines. Articles evaluating the effects of capillary action vs...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Lidia Ruiz-Llorente, Constanza Contreras-Jurado, Mónica Martínez-Fernández, Jesus Maria Paramio, Ana Aranda
BACKGROUND: MicroRNAs (miRNAs) play a unique role in posttranscriptional regulation of gene expression and control different aspects of skin development, homeostasis and disease. Although it is generally accepted that thyroid hormones signaling is important in skin pathophysiology, the role of their nuclear receptors (TRs) in cutaneous miRNA expression has yet to be explored. METHODS: We have used RNAseq to compare the skin miRnome of wild-type mice and genetically modified mice lacking both TRα1 and TRβ, the main thyroid hormone binding isoforms...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Maria Cabanillas, Renata Ferrarotto, Adam Garden, Salmaan Ahmed, Naifa Busaidy, Ramona Dadu, Michelle D Williams, Heath Skinner, Brandon Gunn, Horiana Grosu, Priyanka C Iyer, Marie-Claude Hofmann, Mark Zafereo
Anaplastic thyroid cancer (ATC) is a devastating disease with a dismal prognosis. Patients who have disease confined to the thyroid and who are able to undergo complete surgery and chemoradiation stand the best chance for survival. Unfortunately, nearly 50% of patients at diagnosis have distant metastases at diagnosis and most present with locally advanced, unresectable tumors. Nevertheless, BRAF-mutated ATC patients represent a subset of cases who can benefit from a combination therapy with BRAF and /MEK inhibitors...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
Min Jae Kang, Il Tae Hwang, Hye Rim Chung
BACKGROUND: Iodine is an important element for the thyroid hormone production, and its deficiency or excessive intake is associated with various thyroid diseases. Little is known about the association between iodine status and thyroid function among children and adolescents living in iodine-rich areas, therefore, we analyzed this association using data from a nationwide survey. METHODS: From the Korea National Health and Nutrition Examination Surveys (KNHANES) VI (2013-2015) data, 1288 subjects (711 male) aged 6-19 years who underwent urinary iodine concentration (UIC) test and 1000 subjects (564 male) aged 10-19 years who underwent thyroid function test were included in this study...
May 8, 2018: Thyroid: Official Journal of the American Thyroid Association
Carmen Floriani, Martin Feller, Carole E Aubert, Khadija M'Rabet-Bensalah, Tinh-Hai Collet, Wendy P J den Elzen, Douglas C Bauer, Anne Angelillo-Scherrer, Drahomir Aujesky, Nicolas Rodondi
BACKGROUND: Even though the association between thyroid dysfunction and anemia is commonly described, it is not known whether it is clinically relevant. This study set out to quantify the association of thyroid dysfunction on hemoglobin (Hb) concentration and risk of anemia. A systematic review (MEDLINE and EMBASE, from inception until May 15, 2017) was conducted to interpret the findings in context. METHODS: Participants from the EPIC-Norfolk cohort with available baseline thyrotropin (TSH), free thyroxine (fT4), and Hb were included...
April 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Anna M Sawka, Sally E Carty, Bryan R Haugen, James V Hennessey, Peter A Kopp, Elizabeth N Pearce, Julie A Sosa, Ralph P Tufano, Jacqueline Jonklaas
BACKGROUND: The American Thyroid Association (ATA) is continually striving to improve the quality of its publications. The ATA Guidelines Policies and Procedures Task Force was active during 2017. It recently recommended convening a formal standing committee to review and update policies and procedures for the development of clinical practice guidelines (CPGs) and Statements on an ongoing basis. OBJECTIVE: This statement reviews the history of official ATA publications and discusses the challenges and findings identified by the Task Force...
April 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Jessa E Miller, Neal C Al-Attar, Owen H Brown, Gabrielle G Shaughness, Natalja P Rosculet, Anca M Avram, David T Hughes
BACKGROUND: After initial surgical treatment of differentiated thyroid cancer (DTC) residual lymph node metastases are often found at the time of radioactive iodine (131 I) therapy. Recurrence of DTC is due to persistent disease not removed at initial surgery which also did not respond to 131 I treatment. This study aimed at determining locations of, and reasons for, residual nodal metastases detected by 131 I scans with single-photon emission computed tomography (SPECT/CT) obtained prior to radioiodine therapy following surgical treatment of DTC...
April 23, 2018: Thyroid: Official Journal of the American Thyroid Association
Mizuho S Mimoto, Anara Karaca, Neal Scherberg, Alexandra M Dumitrescu, Samuel Refetoff
An individual with familial dysalbuminemic hyperthyroxinemia (FDH) due to a homozygous mutation (c.653G>A, p.R218H) in the human serum albumin (HSA) gene is reported. The patient was identified during evaluation of abnormal thyroid tests in a large family with multiple levels of consanguinity. He showed a greater increase in total T4 relative to that observed in heterozygous family members. The higher affinity of mutant HSA for T4, together with the large molar excess of HSA relative to thyroid hormones in serum, results in preferential association of T4 with the mutant rather than wildtype HSA in heterozygous individuals...
April 20, 2018: Thyroid: Official Journal of the American Thyroid Association
Michael C Topf, Zi-Xuan Wang, Madalina Tuluc, Edmund A Pribitkin
BACKGROUND: Molecular markers are increasingly used as diagnostic tools in the management of thyroid nodules. There is a paucity of studies evaluating the prevalence of molecular markers in benign lesions. PATIENT FINDINGS: A 68-year-old woman with hypothyroidism presented with a right thyroid nodule which was atypia of undetermined significance on cytology. The fine needle aspirate of the nodule was examined with next-generation sequencing and found to harbor a C228T mutation in the TERT gene, a Q61R mutation in the HRAS gene, and an A113_splice mutation in the EIF1AX gene...
April 19, 2018: Thyroid: Official Journal of the American Thyroid Association
Frederik Verburg, Uwe Maeder, Luca Giovanella, Markus Luster, Christoph Reiners
BACKGROUND: Neck ultrasound (NUS) is currently seen as a main component of follow-up of differentiated thyroid cancer (DTC) and is usually performed regardless of non-stimulated thyroglobulin (Tg) levels. The aim of this study is to determine whether there is a clinical benefit from such a routine NUS in DTC patients. METHODS: We performed a retrospective database study of 3176 cervical ultrasound exams performed in 773 patients between June 15, 1996 and July 1, 2012...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Fadi Nabhan, Kyle Porter, Mark Lupo, Gregory W Randolph, Kepal Narendra Patel, Richard T Kloos
BACKGROUND: RAS mutations are common in the available mutational analysis of cytologically indeterminate (Cyto-I) thyroid nodules. However, their reported positive predictive value (PPV) for cancer is widely variable. The reason for this variability is unknown and it causes clinical management uncertainty. We performed a systematic review evaluating the PPV for cancer in RAS mutation positive Cyto-I nodules and considered variables that might affect residual heterogeneity across the different studies...
April 18, 2018: Thyroid: Official Journal of the American Thyroid Association
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