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Thyroid: Official Journal of the American Thyroid Association

Gilbert A Sigal, Thauany Tavoni, Bruna Silva, Roberto Kalil Filho, Lenine Garcia Brandão, Raul C Maranhão
BACKGROUND: Elevation of LDL-cholesterol is the hallmark of hypothyroidism dyslipidemia, but alterations on HDL plasma levels and metabolism are less understood. The aim of this study was to explore aspects of HDL metabolism and enzymes that act on HDL after a short period of overt hypothyroidism. METHODS: Eighteen women (44±11 years, BMI 27.9±5.2kg/m2) were studied before total thyroidectomy for thyroid cancer, when they were in euthyroid state, and after thyroidectomy, in overt hypothyroidism for 3 weeks, following levothyroxine withdrawal for performance of whole body scan...
November 9, 2018: Thyroid: Official Journal of the American Thyroid Association
Myriem Boufraqech, Dhaval Patel, Naris Nilubol, Astin Shea Powers, Timothy King, Jasmine Shell, Justin Lack, Lisa Zhang, Sudheer Kumar Gara, Viswanath Gunda, Joanna Klubo-Gwiezdzinska, Suresh Kumar, James A Fagin, Jeffrey Knauf, Sareh Parangi, David J Venzon, Martha Quezado, Electron Kebebew
BACKGROUND: BRAF mutation is the most common somatic mutation in thyroid cancer. The mechanism associated with BRAF mutant tumor aggressiveness remains unclear. Lysyl oxidase (LOX) is highly expressed in aggressive thyroid cancers, and involved in cancer metastasis. The objective is to determine whether LOX mediates the effect of the activated MAPK pathway in thyroid cancer. METHODS: The prognostic value of LOX and its association with BRAF mutation was analyzed in the TCGA and an independent cohort...
November 6, 2018: Thyroid: Official Journal of the American Thyroid Association
Weiwei Wang, Jinyuan Mao, Jiajun Zhao, Juming Lu, Li Yan, Jianling Du, Lu Zhaohui, Wang Hai, Xu Mingtong, Bai Xue, Zhu Lin, Chenling Fan, Hong Wang, Hongmei Zhang, Zhongyan Shan, Weiping Teng
Background Recent intervention studies have suggested selenium(Se) as an effective treatment in autoimmune thyroiditis (AIT). However, the exact mechanism is still unclear. The aim of the present study was to explore the effect of Se on thyroid peroxidase antibody (TPOAb) titers in patients with AIT and to analyze a potential impact of the genetic background on the effect of Se supplementation Methods Randomized, placebo-controlled, double-blind trial. 364 patients with elevated TPOAb (>300 IU/mL) were recruited and randomized to receive Se yeast 200 μg/day supplementation or placebo...
November 6, 2018: Thyroid: Official Journal of the American Thyroid Association
Hye-Seon Oh, Jonghwa Ahn, Eyun Song, Ji Min Han, Won Gu Kim, Tae Yong Kim, Won Bae Kim, YoungKee Shong, MinJi Jeon
<i>Background</i> The concept of a dynamic risk stratification scheme has been suggested for individualized management of patients with papillary thyroid carcinoma (PTC). However, there is no specified follow-up strategy for patients with indeterminate response. <i>Methods</i> We evaluated 403 PTC patients who had an indeterminate response during the first 12-24 months after initial therapy. All patients underwent total thyroidectomy with radioactive iodine remnant ablation. Patients were further classified into three groups based on risk of structural persistence/recurrence: a Tg+ group (detectable thyroglobulin (Tg), regardless of anti-thyroglobulin antibody (TgAb) or imaging findings; 196 patients), a TgAb+ group (positive results for TgAb with undetectable Tg, regardless of imaging findings; 46 patients), and an Image+ group (nonspecific findings on neck ultrasonography (US) or faint uptake in the thyroid bed on whole body scan, with undetectable Tg and negative results for TgAb; 161 patients)...
November 1, 2018: Thyroid: Official Journal of the American Thyroid Association
Rodolfo J Galindo, Carolina R Hurtado, Francisco J Pasquel, Rodrigo Garcia Tome, Limin Peng, Guillermo E Umpierrez
BACKGROUND: Current evidence on the incidence and outcomes of patients with thyroid storm in the US is limited to single-center case series. We determined the national incidence of thyrotoxicosis with and without thyroid storm and clinical outcomes among hospitalized patients during a 10-year period in the US. METHODS: Retrospective longitudinal analysis of clinical characteristics, mortality, hospital length-of-stay and costs from 2004 and 2013. We included adults (> 18 years of age) with a primary diagnosis of thyrotoxicosis with and without thyroid storm...
November 1, 2018: Thyroid: Official Journal of the American Thyroid Association
Yui Watanabe, Ryan J Bruellman, Reham Shareef Ebrhim, Mohamed A Abdullah, Alexandra M Dumitrescu, Samuel Refetoff, Roy E Weiss
Dyshormonogenic congenital hypothyroidism (CH) generally results from biallelic defects in thyroid hormone synthesis genes. Whole exome sequencing (WES) allows easier identification of multiple gene defects. We present 2 Sudanese families with CH resulting from oligogenic defects identified by WES. In Family 1, the proposita with CH and goiter was heterozygous for three TPO, one TG and one DUOX2 mutations, including three novel variants inherited from both parents. In Family 2, two brothers with psychomotor delay and goiter were homozygous for digenic mutations in the DUOX2 and DUOX1 genes while their asymptomatic parents were heterozygous...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Jacqueline Jonklaas, Eshetu Tefera, Nawar Shara
Background Physician characteristics and perceptions and their effect on choice of therapies for patients with thyroid cancer have been well-studied. Some data also exist about physician characteristics and prescribing treatment for subclinical hypothyroidism. The effect of physician characteristics on prescribing thyroid preparations for treating overt hypothyroidism is less studied. Methods Members of the American Thyroid Association were surveyed in 2017. Physicians were presented with thirteen different theoretical patients with hypothyroidism and asked to choose among 6 therapeutic options, including levothyroxine, synthetic combination therapy, thyroid extract, and liothyronine monotherapy...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Jun Pan, Hui Li, Yun Fang, Yibin Shen, Xueyu Zhou, Feng Zhu, Lixian Zhu, Yehui Du, Xiongfei Yu, Yan Wang, Xin-Hui Zhou, Yingying Wang, Yijun Wu
BACKGROUND: Hypothyrodism is a common hormone deficiency condition. Regenerative medicine approaches, such as a bioengineered thyroid, have been proposed as potential therapeutic alternatives for patients with hypothyroidism. Here we demonstrate a novel approach to generate thyroid grafts using decellularized rat thyroid matrix. MATERIALS AND METHODS: Isolated rat thyroid glands were perfused with 1% SDS to generate a decellularized thyroid scaffold. The rat thyroid scaffold was then recellularized with rat thyroid cell line to reconstruct the thyroid by perfusion-seeding technique...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Eyun Song, Minkyu Han, Hye-Seon Oh, Won Woong Kim, MinJi Jeon, Yu-Mi Lee, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, YoungKee Shong, Suck Joon Hong, Tae-Yon Sung, Won Gu Kim
BACKGROUND: Current guidelines allow lobectomy as treatment for papillary thyroid carcinomas (PTCs) sized 1-4 cm as previous studies reported no clear survival advantages for total thyroidectomy (TT). However, data on recurrence based on surgical extent are limited. MATERIALS AND METHODS: We enrolled 2,345 patients with PTC sized 1-4 cm. Those with lateral cervical lymph node metastasis or initial distant metastasis were excluded. Disease-free survival (DFS) was compared after 1:1 propensity score matching by age, sex, tumor size, extrathyroidal extension, multifocality, and cervical lymph node metastasis...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Nicole A Cipriani, Michael G White, Peter Angelos, Raymon H Grogan
BACKGROUND: Management of large thyroid nodules is controversial, as data are conflicting regarding overall rates of malignancy (ROM) in all nodules and frequency of false-negative fine-needle aspiration results (FNR) in cytologically benign nodules. This meta-analysis aimed to evaluate and compare ROM and FNR in small versus large nodules published in the literature. METHODS: Articles indexed in PubMed, written in English, published electronically or in print on or prior to December 8 2017 were searched for "false negative thyroid size or cm" and "malignancy rates benign thyroid nodules...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Aneesh Patel, Sun Y Lee, Alex Stagnaro-Green, Douglas MacKay, Andrea W Wong, Elizabeth N Pearce
BACKGROUND: Iodine is essential for thyroid hormone production and fetal development. Even mild maternal iodine deficiency in gestation may be associated with impaired child neurodevelopment. Iodine requirements increase during pregnancy and lactation. Supplements containing 150 μg/day are recommended by the American Thyroid Association for all U.S. women who are pregnant, lactating, or planning pregnancy. The contribution of multivitamin supplements as an iodine source for pregnant and nonpregnant US adults has not been well studied...
October 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Chi Yun Yu, Omar Saeed, Alyse S Goldberg, Shafaq Farooq, Rouhi Fazelzad, David P Goldstein, Richard W Tsang, James Brierley, Shereen Ezzat, Lehana Thabane, Charlie H Goldsmith, Anna M Sawka
BACKGROUND: The potential risk of subsequent malignant neoplasms (SMNs) after radioactive iodine (RAI) treatment of thyroid cancer (TC), is an important concern. METHODS: We updated a systematic review comparing the risk of SMNs in TC patients treated with RAI to TC patients without RAI. We searched six electronic databases (up to March, 2018), supplemented with a hand search. Two reviewers independently screened citations, reviewed full-text papers, and critically appraised/abstracted data...
October 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Victor Brun Boesen, Ulla Feldt-Rasmussen, Jakob Bue Bjorner, Per Cramon, Mogens Groenvold, Birte Nygaard, Åse Krogh Rasmussen, Tina Vilsbøll, Torquil Watt
Background The impact of thyroid disease on quality of life is an important disease aspect that is best investigated by patient-reported outcomes. Recent patient-reported outcomes research has raised concern about the validity of traditional retrospective questionnaires. Therefore, ecological momentary assessments of patients' subjective well-being have been introduced to avoid recall bias and improve contextual validity. Despite theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported outcome measure (ThyPRO) and a momentary (here-and-now) version of ThyPRO...
October 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Karn Wejaphikul, Stefan Groeneweg, Prapai Dejkhamron, Kevalee Unachak, W Edward Visser, V Krishna Chatterjee, Theo J Visser, Marcel Meima, Robin Peeters
Leu341 has been predicted from crystal structure as an important residue for thyroid hormone receptor (TR) β function, but this has never been confirmed in functional studies. Here, we describe a novel p.L341V mutation as a cause of resistance to thyroid hormone β, suggesting an important role for Leu341 in TRβ function. In silico and in vitro studies confirmed that substituting Leu341 with Val and other non-polar amino acids impair sensitivity of TRβ for T3 with various degrees, depending on their side-chain size and orientation...
October 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Christel Hedman, Therese Djärv, Peter Strang, Catharina Ihre Lundgren
BACKGROUND: Differentiated thyroid cancer (DTC) has a good prognosis but a remaining risk of recurrence and need for lifelong follow-up. The aim was to study changes in health-related quality of life (HRQoL) from diagnosis to one year of follow-up. METHODS: In this prospective population-based study, patients were identified from all the Swedish departments of oncology treating DTC. In total, 487 patients diagnosed with DTC between 2012 and 2017 were invited to answer the Swedish version of the Short Form-36 Health Survey (SF-36) and a study-specific questionnaire at diagnosis and after one year...
October 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Yongkun Sun, Feng Du, Ming Gao, Qinghai Ji, Zhendong Li, Yuan Zhang, Zhuming Guo, Jun Wang, Xiangjin Chen, Jinwan Wang, Yihebali Chi, Pingzhang Tang
BACKGROUND: The prognosis of advanced or metastatic medullary thyroid carcinoma (MTC) is poor, and there are few therapeutic options. Anlotinib has previously shown promising antitumor activity on MTC in preclinical models and a Phase I study. This Phase II clinical trial was devised to confirm the antitumor activity of anlotinib in patients with advanced or metastatic MTC. METHODS: Patients with unresectable locally advanced or metastatic MTC received once daily oral anlotinib 12 mg, two weeks on/one week off, until disease progression, death, unacceptable toxicity, or withdrawal of consent for any reason...
October 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Eyun Song, Yu-Mi Lee, Hye-Seon Oh, MinJi Jeon, Dong Eun Song, Tae Yong Kim, Won Bae Kim, YoungKee Shong, Tae-Yon Sung, Won Gu Kim
BACKGROUND: The recently published eighth edition of the American Joint Committee on Cancer (AJCC) staging system has emphasized the importance of gross extrathryoidal extension (gETE) while classifying the tumor (T) stage in differentiated thyroid carcinoma (DTC). However, the clinical impact of gETE invading only the strap muscles or the recurrent laryngeal nerve (RLN) remains unclear due to scarce and conflicting data. METHODS: A retrospective cohort study was carried out in patients with DTC who underwent thyroid surgery from 1996 to 2005...
October 25, 2018: Thyroid: Official Journal of the American Thyroid Association
Maria Lúcia D'Arbo Alves, Manoel Henrique Cintra Gabarra, Anderson Marliere Navarro
BACKGROUND: In 2007 and 2015 we conducted two studies in Ribeirão Preto, São Paulo, Brazil, on schoolchildren of both sexes attending schools of three different socioeconomic levels (School 1 : low; School 2 : middle; School 3: high). METHODS: Iodine concentrations were measured in samples of kitchen salt from the home provided by the schoolchildren and in urine samples and these levels were compared with the thyroid volume by clinical assessment. RESULTS: In 2007, we found a marked discrepancy in iodine concentrations in salt samples in 300 schoolchildren of both sexes ranging in age from eight to 10 years...
October 25, 2018: Thyroid: Official Journal of the American Thyroid Association
Till Ittermann, Katharina Wittfeld, Matthias Nauck, Robin Bülow, Norbert Hosten, Henry Völzke, Hans J Grabe
BACKGROUND: Previous patient studies suggest that thyroid dysfunction affects volumes of particular regions of the brain. So far, population-based data related to this topic are lacking. The aim of this study was to investigate associations of serum levels of thyrotropin (TSH), free triiodothyronine, and free thyroxine (fT4) with total brain volume, gray matter volume, white matter volume (WMV), and hippocampal volume (HV) in a population-based study. METHODS: Data on 2557 individuals were pooled from two independent population-based surveys of the Study of Health in Pomerania conducted in Northeast Germany...
October 25, 2018: Thyroid: Official Journal of the American Thyroid Association
Panli Li, Aimi Zhang, Ye Liu, Chunyuan Xu, Linglin Tang, Hong Yuan, Qiufang Liu, Xiuying Wang, Dagan Feng, Lisheng Wang, Gang Huang, Shaoli Song
BACKGROUND: Therapy with 131I is a well-established treatment method for post-surgical differentiated thyroid carcinoma (DTC). A fixed discharge time is generally set regardless of individual differences in residual body radioactivity (RBA). We aimed to study the RBA of each patient to find the attenuation law and to underlying factors in order to predict the time point for a safe, scientifically sound discharge plan. METHODS: 231 DTC patients undergoing 131I treatment were all treated with 3...
October 23, 2018: Thyroid: Official Journal of the American Thyroid Association
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