Read by QxMD icon Read

Thyroid: Official Journal of the American Thyroid Association

Michal Gershinsky, Walid Saliba, Idit Lavi, Chen Shapira, Naomi Gronich
OBJECTIVE: Agranulocytosis occurs in 0.2-0.5% of patients treated with the antithyroid drugs (ATDs) methimazole and propylthiouracil. Our objective was to evaluate the risk of ATD-related agranulocytosis in patients with amiodarone-induced thyrotoxicosis, and to compare it with the agranulocytosis risk in patients with thyrotoxicosis due to other etiologies, treated with ATDs. DESIGN: Retrospective cohort study Setting: Clalit Health Services database Participants: 14,781 adult patients with thyrotoxicosis, newly treated with an ATD between 1...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Marina N Nikiforova, Alyaksandr V Nikitski, Federica Panebianco, Cihan Kaya, Linwah Yip, Michelle D Williams, Simion I Chiosea, Raja Seethala, Somak Roy, Vincenzo Condello, Lucas Santana-Santos, Abigail I Wald, Sally E Carty, Robert L Ferris, Adel K El-Naggar, Yuri E Nikiforov
BACKGROUND: Hyalinizing trabecular tumor (HTT) is a rare thyroid neoplasm with a characteristic trabecular growth pattern and hyalinization. This lesion has been a subject of long-term controversy surrounding its genetic mechanisms, relationship to papillary thyroid carcinoma, and malignant potential. Due to the presence of nuclear features shared with papillary carcinoma, HTT frequently contribute to false-positive cytology which hampers patient management. The goal of this study was to apply genome-wide sequencing analyses to elucidate the genetic mechanisms of HTT and its relationship to papillary carcinoma...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Mads Lillevang-Johansen, Bo Abrahamsen, Henrik Løvendahl Jørgensen, Thomas Heiberg Brix, Laszlo Hegedus
IMPORTANCE: Cardiovascular disease remains the most prevalent cause of death in hyperthyroidism. However, the impact on cardiovascular events of varying thyroid status and that of treatment remain unclarified. OBJECTIVE: To investigate the association between hyperthyroidism and cardiovascular events in treated and untreated hyperthyroid individuals, as well as exploring the impact of cumulative periods of hyperthyroidism, as a proxy for undertreatment, on cardiovascular events...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Hyemi Kwon, Yoosoo Chang, Ara Cho, Jiin Ahn, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Hocheol Shin, Seungho Ryu, Eun-Jung Rhee
BACKGROUND: No cohort studies have evaluated the effect of obesity on the incidence of thyroid cancer according to metabolic health status. Therefore, we examined the association of body mass index (BMI) and metabolic health status with thyroid cancer risk. METHODS: We performed a cohort study involving 255,051 metabolically healthy (MH) and metabolically unhealthy (MUH) adults free of thyroid cancer at baseline who were followed for a median of 5.3 years. A parametric proportional hazard model was used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI)...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Jessica Farebrother, Michael Zimmermann, Vincent Assey, Mary Christine Castro, Mohamed Cherkaoui, Ralph Fingerhut, Qingzhen Jia, Tomislav Jukic, Anselimo Makokha, Teofilo O L San Luis, Rita Wegmuller, Maria Andersson
Background In areas of incomplete salt iodization coverage, infants and children aged 6-24-months weaning from breastmilk and receiving complementary foods are at risk of iodine deficiency. However, few data exist on the risk of excessive iodine intakes in this age group. Thyroglobulin (Tg) is a sensitive marker of iodine intake in school-age children and adults and may be used to estimate the optimal iodine intake range in infancy. Objective To assess the association of low and high iodine intakes with Tg and thyroid function in weaning infants...
January 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Kirstine Stochholm, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cliius Nielsen, Kim Brixen, Anja Lisbeth Frederiksen, Christian Godballe
BACKGROUND: Survival of medullary thyroid carcinoma (MTC) subgroups in relation to the general population is poorly described. Data on the factors predicting long-term biochemical cure in MTC patients is non-existent on a population level. We conducted a nationwide retrospective cohort study of MTC in Denmark from 1997 to 2014, aiming to detect subgroups with survival similar to that of the general population and to identify prognostic factors for disease-specific survival and long-term biochemical cure...
January 8, 2019: Thyroid: Official Journal of the American Thyroid Association
Julia Fassbender, Hans-Peter Holthoff, Zhongmin Li, Martin Ungerer
Cyclic peptides derived from some cylindrical loops of the leucin-rich repeat domain (LRD) of the thyroid-stimulating hormone receptor (TSHR) have been shown to treat disease manifestations in a mouse model of Graves´ disease during a long-term protocol of 4-weekly immunisations with adenovirus coding for the TSHR A subunit (Ad-TSHR289). In a follow-up study, we tested two additional cyclic peptides which were shortened in order to obtain additional information on the minimally involved epitopes, and to enable easier production conditions...
January 8, 2019: Thyroid: Official Journal of the American Thyroid Association
Katherine A Hill, Linwah Yip, Sally E Carty, Kelly L McCoy
BACKGROUND: Compared to those with sporadic primary hyperparathyroidism (SPHP), MEN-1 patients with primary hyperparathyroidism (MPHP) typically require more extensive dissection and have higher recurrence rates. Little is known about the risk of concomitant thyroid cancer in either setting. We aimed to determine the rates and characteristics of thyroid cancer for MPHP versus SPHP patients having parathyroidectomy. METHODS: Patients with MPHP (diagnosed by clinical and/or genetic criteria) or SPHP who had initial or reoperative parathyroid exploration from 1967-2014 were identified via a prospective database...
January 4, 2019: Thyroid: Official Journal of the American Thyroid Association
Lois Elizabeth Donovan, Amy Metcalfe, Alex C Chin, Jennifer M Yamamoto, Heidi Virtanen, Jo-Ann Johnson, Richard Krause
BACKGROUND: Population, assay and trimester specific reference intervals for thyroid function tests are necessary to accurately assess thyroid status and manage thyroid disease throughout pregnancy. This study's objective was to verify if the manufacturer's recommended trimester specific reference intervals for thyroid tests and American Thyroid Association's recommended Total T4 (TT4) pregnancy reference intervals were verifiable and appropriate for use in our population. METHODS: Blood samples were obtained from the following sources: stored frozen surplus blood from women undergoing routine aneuploidy screening (first and second trimester samples, n = 274), and women participating in an observational cohort study, (second and third trimester samples, n = 135) and blood collected from women presenting for assessment to the labour and delivery ward (third trimester samples n =35)...
December 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Lingyu Bao, Julia Rodiger, Sunmi Park, Liezhen Fu, Bingyin Shi, Sheue-Yann Cheng, Yun-Bo Shi
BACKGROUND: Thyroid hormone (T3) is critical for vertebrate development and affects the function of many adult tissues and organs. Its genomic effects are mediated by thyroid hormone nuclear receptors (TRs) present in all vertebrates. The discovery of patients with resistance to thyroid hormone (RTHβ) over 50 years ago and subsequent identification of the genetic mutations only in the THRB gene in these patients suggest that mutations in the THRA gene may have different pathological manifestations in humans...
December 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Xiaowei He, Dan Wu, Cuining Hu, Ting Xu, Yuanxin Liu, Chao Liu, Bo Xu, Wei Tang
BACKGROUND: Metformin is the most-prescribed oral medication to lower blood glucose worldwide. Some data suggest that metformin may have a role in the treatment of patients with thyroid nodules, but contrasting results are reported in different settings. This study explores and critically re-evaluates the knowledge on this topic. METHODS: A literature search identified 250 records. Studies evaluating the size of thyroid nodules before and after metformin treatment were included...
December 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Min Joo Kim, Shinje Moon, Byung-Chul Oh, Dawoon Jung, Kyungho Choi, Young Joo Park
Background Diethylhexyl phthalate (DEHP) is widely used in industrial products, particularly as plasticizers and softeners. Because they are used extensively, DEHP has been detected in humans worldwide. Although epidemiological studies suggest that DEHP can disrupt the function of hypothalamic-pituitary-thyroid (HPT) axis, evidence on the association between DEHP exposure and thyroid function remains inconclusive. Therefore, we performed a comprehensive meta-analysis to investigate the association between DEHP exposure and HPT axis in humans...
December 27, 2018: Thyroid: Official Journal of the American Thyroid Association
Toshihiko Sakai, Iwao Sugitani, Aya Ebina, Osamu Fukuoka, Kazuhisa Toda, Hiroki Mitani, Keiko Yamada
BACKGROUND: Prospective trials of active surveillance for asymptomatic papillary microcarcinoma (T1aN0M0) since the 1990s have shown progression rates of only 5-10%. Late rescue surgery after progression had no deleterious effects on mortality and morbidity. The 2015 American Thyroid Association guidelines approved active surveillance for very low-risk papillary thyroid carcinoma (PTC) as an alternative method to immediate surgery. However, there is no study that evaluates long-term active surveillance for T1b tumors...
December 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Yuchen Jin, Maomei Ruan, Lingxiao Cheng, Hao Fu, Min Liu, Shiwei Sheng, Libo Chen
BACKGROUND: Radioiodine (I-131) remnant ablation (RRA) has become a key step for the post-operative treatment of differentiated thyroid cancer (DTC). However, inadequate or excessive I-131 is common using fixed activities. This study was designed to explore the feasibility of radioiodine uptake and thyroglobulin (RAIU-Tg)-guided RRA. METHODS: A total of 277 patients were randomized into the RAIU-Tg-based activity group and a fixed activity of 3.7 GBq group at a ratio of 4:1...
December 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Wang Na, Yiqi Li, Jing Wei, Jun Pu, Rui Liu, Qi Yang, Haixia Guan, Bingyin Shi, Peng Hou, Meiju Ji
BACKGROUND: TBX1 is a member of the T-box family of transcription factors characterized by a conserved DNA binding domain termed T-box. TBX1 has been reported to be downregulated in mouse skin tumors, and negatively regulated tumor cell growth; however, its role and exact mechanism in human cancers including thyroid cancer remain totally unknown. METHODS: Quantitative RT-PCR (qRT-PCR) and western blot assays were performed to evaluate the expression of investigated genes...
December 13, 2018: Thyroid: Official Journal of the American Thyroid Association
Ana Marcella Rivas, Eneko Larumbe-Zabala, Subhanudh Thavaraputta, Edna Juarez, Avinash Adiga, Joaquin Lado-Abeal
OBJECTIVE: Our institution, a safety net, university, tertiary hospital located in West Texas has a high number of hospital admissions for complicated thyrotoxicosis. We hypothesized that unfavorable socioeconomic conditions result in increased risk of poor outcomes in hyperthyroid patients, and upshot rates of hospitalization for thyrotoxicosis in West Texas. The primary aim of our study was to identify factors associated with admission for complicated thyrotoxicosis in patients living in the Panhandle and Llano Estacado of Texas...
December 7, 2018: Thyroid: Official Journal of the American Thyroid Association
Myrna Virreira Bermudez, Ling Jin, Sami Djerbib, Xavier De Deken, Francoise Miot, Claude Massart, Michal Svoboda, Jacqueline Van Sande, Renaud Beauwens, Jacques E Dumont, Alain Boom
BACKGROUND: The intrafollicular space of thyroid follicles is the storage compartment for thyroid hormones. Its pH has been established at around 7.6 at least after thyrotropin (TSH) stimulation. This alkaline intrafollicular pH is thought to be critical for iodide coupling to thyroglobulin and internalization of iodinated thyroglobulin. At least in mice, this alkalinization requires the expression of pendrin (Slc26a4) within the apical membrane, and a lack of pendrin results in acidic follicular lumen pH...
December 7, 2018: Thyroid: Official Journal of the American Thyroid Association
Carla Colombo, Marina Muzza, Maria Carla Proverbio, Delfina Tosi, Davide Soranna, Chiara Pesenti, Stefania Rossi, Valentina Cirello, Simone De Leo, Nicola Fusco, Monica Miozzo, Gaetano Bulfamante, Leonardo Vicentini, Stefano Ferrero, Antonella Zambon, Silvia Tabano, Laura Fugazzola
BACKGROUND: The need to integrate the classification of cancer with information on the genetic pattern has emerged in recent years for several tumors. PATIENTS AND METHODS: The genomic background of a large series of 208 papillary thyroid cancers (PTC) followed at a single Center was analysed by a custom MassARRAY genotyping platform (PTC-MA), which allows the simultaneous detection of 19 common genetic alterations including point mutations and fusions. RESULTS: 71% of the PTCs was genetically classified, being BRAFV600E variant and TERT promoter mutations the most frequent heterozygous alterations (42 and 23...
December 1, 2018: Thyroid: Official Journal of the American Thyroid Association
Salman Razvi, Tim Korevaar, Peter Taylor
BACKGROUND: Recent reports suggest that prescriptions for thyroid hormones have increased. We therefore analysed recent trends in and determinants of prevalence of treated hypothyroidism across the United Kingdom (UK). METHODS: UK-wide data held by the National Health Service and the Office of National Statistics were examined. The main outcome measured was trends in prevalence of treated hypothyroidism between 2005 till 2014. In addition, linear trend forecasting was performed to estimate projected trends in prevalence of treated hypothyroidism up to the year 2025...
December 1, 2018: Thyroid: Official Journal of the American Thyroid Association
Sarantis Livadas, Christina Bothou, Ioannis Androulakis, Anastasios Boniakos, Nicholas Angelopoulos, Leonidas Duntas
BACKGROUND: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, approximately 90% of patients continue treatment long term. However, accumulating evidence suggests that many patients, for whom the indication for its administration is not adequately established and the diagnosis is not well documented, are overusing it. This study aimed to evaluate the necessity for and determine potential prognostic factors of long-term LT4 supplementation. METHODS: A prospective clinical cohort follow-up study was carried out...
November 30, 2018: Thyroid: Official Journal of the American Thyroid Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"