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Thyroid: Official Journal of the American Thyroid Association

Shinje Moon, Min Joo Kim, Jae Myung Yu, Hyung Joon Yoo, Young Joo Park
Objectives To determine the impact of subclinical hypothyroidism (SCH) on the risk of cardiovascular disease (CVD) and all-cause mortality, we performed a comprehensive meta-analysis, according to the age or coexisting CVD risk status of the participants. Methods Studies regarding the association of SCH with all-cause mortality from PubMed and Embase databases were included. We calculated the pooled relative risk (RR) of CVD and all-cause mortality using the Mantel-Haenszel method. We conducted a subgroup analysis of participants with high CVD risk, including history of coronary, cerebral, or peripheral artery disease; dilated cardiomyopathy; heart failure; atrial fibrillation; venous thromboembolism; diabetes mellitus; or chronic kidney disease...
July 6, 2018: Thyroid: Official Journal of the American Thyroid Association
Carole Saba, Sophie Guilmin-Crepon, Delphine Zénaty, Laetitia Martinerie, Anne Paulsen, Dominique Simon, Caroline Storey, Sophie Dos Santos, Jeremie Haignere, Damir Mohamed, Jean-Claude Carel, Juliane Léger
BACKGROUND: An increase in the incidence of congenital hypothyroidism (CH) with a normally located gland has been reported worldwide. Affected individuals display transient or permanent CH during follow-up in childhood. We aimed to determine the prevalence of transient CH and to investigate the possibility of distinguishing between transient and permanent CH in early infancy. METHODS: This observational cohort study included all patients identified by systematic neonatal screening for CH in the northern Parisian region between 2002 and 2012 and treated for CH with a normally sited gland...
July 3, 2018: Thyroid: Official Journal of the American Thyroid Association
Xiaochun Teng, Zhongyan Shan, Chenyan Li, Xiaohui Yu, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Jianling Du, Shaowei Zhang, Zhengnan Gao, Xiaomei Zhang, Ling Li, Chenling Fan, Weiping Teng
Background Pregnant women are highly vulnerable to iron deficiency (ID) due to the increased iron needs during pregnancy. ID decreases circulating thyroid hormone concentrations likely through impairment of iron-dependent thyroid peroxidase (TPO). The present study aimed at exploring the association between ID and hypothyroxinemia in a retrospective cohort of pregnant women in China. Methods To investigate the relationship between ID and hypothyroxinemia, we retrospectively analyzed 723 pregnant women in the present study, including 675 and 309 women in the second trimester and third trimester, respectively...
July 3, 2018: Thyroid: Official Journal of the American Thyroid Association
Ting Wang, Minmin Jiang, Yanjun Ren, Qingmin Liu, Gang Zhao, Chenjian Cao, Hongmei Wang
BACKGROUND: The purpose of this study was to evaluate health-related quality of life (HRQoL) of community thyroid cancer survivors in Hangzhou, China, and to explore the important correlates defining HRQoL. METHODS: All thyroid cancer patients who met study criteria in 183 communities were invited to participate (N = 1551). A self-administered questionnaire including collection of personal information and HRQoL instruments was completed by each participant (n = 970), with a response rate of 62...
July 2, 2018: Thyroid: Official Journal of the American Thyroid Association
Ben Ma, Wen-Jun Wei, Weibo Xu, Yu Wang, Haixia Guan, Jingbin Fan, Zhihong Zhao, Duo Wen, Shuwen Yang, Yu-Long Wang, Bin Chang, Qing-Hai Ji
Background Recently, thermal ablation has been proposed for treating primary papillary thyroid carcinoma (PTC), triggering an extensive debate. Our study aimed to analyze surgical outcomes of post-ablation cases to investigate the effectiveness and safety of thermal ablation in primary PTC. Methods We retrospectively searched for primary PTC patients treated with thermal ablation from our medical record database prior to August 2017. The surgical patients met the following criteria: 1) primary PTC treated with thermal ablation, 2) with findings suspicious for malignancy of the post-ablation lesions on ultrasound (US) or malignancy confirmed by cytology, or with clinical evidence of cervical lymph node metastasis (LNM), 3) written informed consent for surgery, 4) preference for definite diagnosis of the post-ablation lesions for the patients without evidence for malignant findings, 5) tolerance of a thyroidectomy and without severe illness...
June 30, 2018: Thyroid: Official Journal of the American Thyroid Association
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Lisa A Orloff, Sam M Wiseman, Victor J Bernet, Thomas J Fahey, Ashok R Shaha, Maisie L Shindo, Samuel K Snyder, Brendan C Stack, John B Sunwoo, Marilene B Wang
BACKGROUND: Hypoparathyroidism (hypoPT) is the most common complication following bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. The objective of this American Thyroid Association Surgical Affairs Committee Statement is to provide an overview of its diagnosis, prevention, and treatment. SUMMARY: HypoPT occurs when a low intact parathyroid hormone (PTH) level is accompanied by hypocalcemia...
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Soledad Bárez-López, Meredith D Hartley, Carmen Grijota-Martínez, Thomas S Scanlan, Ana Guadaño-Ferraz
BACKGROUND: Loss of function mutations in the thyroid hormone (TH)-specific cell membrane transporter, the monocarboxylate transporter 8 (MCT8), lead to profound psychomotor retardation and abnormal TH serum levels, with low thyroxine (T4) and high triiodothyronine (T3). Several studies point to impaired TH transport across brain barriers as a crucial pathophysiological mechanism resulting in cerebral hypothyroidism. Treatment options for MCT8-deficient patients are limited and are focused on overcoming the brain barriers...
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Chun-Rong Chen, Sandra M McLachlan, Paul A Hubbard, Randall McNally, Ramachandran Murali, Basil Rapoport
BACKGROUND: The high constitutive, or ligand-independent, activity of the thyrotropin receptor (TSHR) is of clinical importance in some thyroid conditions, particularly well-differentiated thyroid carcinoma remnants following incomplete ablative therapy (surgery and radioiodine). Under these conditions, even total suppression of TSH by thyroid hormone administration does not fully reduce TSHR activity, a driver of thyrocyte growth. METHODS: CS-17 is a murine monoclonal antibody that has inverse agonist activity in that it suppresses TSHR constitutive activity...
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Yoon Young Cho, Min Jin Kang, Soo Kyoung Kim, Jung Hwa Jung, Jong Ryeal Hahm, Tae Hyuk Kim, Joo Young Nam, Byung-Wan Lee, Yong-Ho Lee, Jae Hoon Chung, Sun Ok Song, Sun Wook Kim
BACKGROUND: Metformin, the most widely used drug for type 2 diabetes, has recently attracted attention with regard to its antitumor activity. However, clinical studies have yielded conflicting results regarding the association between metformin and thyroid cancer development, despite its antitumor effect in preclinical studies. METHODS: This is a retrospective cohort study using the Korean National Health Insurance claim database. Matched populations of 128,453 metformin users and 128,453 non-users were analyzed for thyroid cancer incidence...
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Leo Lam, Warwick Bagg, Geoff Smith, Weldon Wai Chiu, Martin James Middleditch, Julie Ching-Hsia Lim, Campbell Vance Kyle
BACKGROUND: Exclusion of analytical interference is important when there is discrepancy between clinical and laboratory findings. However, interferences on immunoassays are often mistaken as isolated laboratory artefacts. The mechanism of a rare cause of interference in two patients that caused erroneous thyroid function tests, and also affects many other biotin dependent immunoassays, was characterized and reported. PATIENT FINDINGS: Patient 1 was a 77-year-old female with worsening fatigue while taking carbimazole over several years...
June 29, 2018: Thyroid: Official Journal of the American Thyroid Association
Tim Korevaar, Lidia Minguez-Alarcón, Carmen Messerlian, Ralph de Poortere, Paige Williams, Maarten Broeren, Russ Hauser, Irene Souter
BACKGROUND: While overt thyroid disease is a well-known risk factor for infertility, the potential consequences of mild thyroid dysfunction or thyroid autoimmunity remain unknown. While experimental studies suggest a considerable role for thyroid hormone in the physiological mechanisms of ovarian reserve, translation of such findings to studies in humans remains sparse. A potential role for thyroid function in female reproduction is especially relevant when the cause of infertility remains unknown, such as in women with diminished ovarian reserve (DOR) or unexplained infertility...
June 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Jakob Schmidt Jensen, Christian Grønhøj, Christian Mirian, David Hebbelstrup Jensen, Jeppe Friborg, Christoffer Holst Hahn, Tina Klitmoeller Agander, Thomas Hjuler
BACKGROUND: Thyroid cancer constitutes a major and increasing proportion of head and neck cancers in children and adolescents. The purpose of this study was to determine incidence and survival of thyroid cancer in Danish patients aged 0-24 years from 1980 to 2014. METHODS: We included patients aged 0-24 years registered with primary thyroid cancer in the Danish Cancer Registry or the Danish Pathology Data Bank during 1980-2014. Crude incidence-rates and age-adjusted incidence-rates (AAIR) per 100,000, average annual percent change (AAPC), and overall survival (OS) were evaluated in relation to sex, histopathological tumor type, age at diagnosis, and year of diagnosis...
June 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Naoki Hattori, Kohzo Aisaka, Kazuhisa Chihara, Akira Shimatsu
<b><i>Background</i></b>: Macro-thyroid-stimulating hormone (macro-TSH) is a high-molecular-weight form of TSH that leads to hyperthyrotropinemia. This study was undertaken to examine the prevalence and nature of macro-TSH in females of reproductive age. <b><i>Methods</i></b>: Blood samples were taken from 1,794 female patients who visited the Hamada Obstetric and Gynecology Hospital in Tokyo, Japan complaining of infertility. The serum of 305 patients with TSH concentrations > 2...
June 26, 2018: Thyroid: Official Journal of the American Thyroid Association
Samantha Tam, Moran Amit, Mongkol Boonsripitayanon, Naifa Busaidy, Maria Cabanillas, Steven G Waguespack, Neil D Gross, Elizabeth G Grubbs, Michelle D Williams, Stephen Y Lai, Erich Sturgis, Mark Zafereo
INTRODUCTION: Risk stratified treatment strategies have become a focus in the treatment of differentiated thyroid cancer (DTC). In the 2015 American Thyroid Association treatment guidelines, adjuvant treatment with radioactive iodine (RAI) is considered in the presence of minimal extrathyroidal extension (mETE). This study aims to investigate the prognostic significance of mETE and tumor size in patients with DTC. METHODS: Retrospective review of 2,323 consecutive patients treated surgically for T1-3 and M0 DTC from 2000-2015 was undertaken at The University of Texas MD Anderson Cancer Center...
June 23, 2018: Thyroid: Official Journal of the American Thyroid Association
Thomas J Semrad, Theresa Keegan, Alison M Semrad, Ann Brunson, D Gregory Farwell
BACKGROUND: In an era of rising differentiated thyroid cancer incidence, the rate and impact of neck reoperation may inform the intensity of earlier interventions and surveillance. In this study, we sought to define predictors of neck reoperation and to assess its impact on survival. METHODS: Using California Cancer Registry linked to California Office of Statewide Health Planning and Development records, we performed a retrospective cohort study of 24,230 patients with total or near total thyroidectomy for papillary or follicular thyroid cancer during 1991-2008 and follow up through 2013...
June 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Akihiro Kaneko, Kiminori Kubo, Shuji Fukata, Nobutaka Inoue
No abstract text is available yet for this article.
June 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Bryan Minh Tran, David James Roshan, Earl Abraham, Laura Y Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi
BACKGROUND: Although the importance of tumor size in papillary thyroid cancer (PTC) is well established, there is no research to investigate whether age modifies the impact of tumor size, and conflicting evidence regarding optimal size thresholds for prognostic discrimination. We aimed to verify that tumor size is an independent prognostic factor in PTC, to investigate the impact of patient age, and to identify optimal size cut-offs for risk stratification using objective measures of model performance...
June 19, 2018: Thyroid: Official Journal of the American Thyroid Association
Jonathon O Russell, Angkoon Anuwong, Gianlorenzo Dionigi, William B Inabnet, Hoon Yub Kim, Gregory Randolph, Jeremy D Richmon, Ralph P Tufano
The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a new approach to the central neck that avoids an anterior cervical incision. This approach can be performed with endoscopic or robotic assistance and offers access to the bilateral central neck. It has been completed safely in both North American and, even more extensively, international populations. With any new technology or approach, complications during the learning curve, expense, instrument limitations, and overall safety may affect its ultimate adoption and utility...
June 18, 2018: Thyroid: Official Journal of the American Thyroid Association
Juan P Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Koon Kim, Nicole M Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-Hoon Kim, Ian Hargraves, Victor Bernet, Victor Montori, Young Joo Park, R Michael Tuttle
BACKGROUND: The 2015 American Thyroid Association guidelines recognize active surveillance as an alternative to immediate surgery in patients with papillary microcarcinomas (PMCs). As a way to incorporate active surveillance as one of the management options for patients with PMCs, we describe the development and initial testing of a tool to support conversations between clinicians and patients with PMCs considering treatment options. METHODS: Thyroid Cancer Treatment Choice was developed using an iterative process based on the principles of interaction, design and participatory action research...
June 15, 2018: Thyroid: Official Journal of the American Thyroid Association
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