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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/28635571/comparison-of-the-7th-and-8th-editions-of-the-ajcc-uicc-tnm-staging-system-for-differentiated-thyroid-cancer
#1
Mijin Kim, Won Gu Kim, Hye-Seon Oh, Suyeon Park, Hyemi Kwon, Dong Eun Song, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Tae-Yon Sung, MinJi Jeon
OBJECTIVE: To evaluate the efficacy and prognostic validity for disease-specific survival (DSS) of the 8th edition American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor-node-metastasis (TNM) staging system (TNM-8) compared with the 7th edition (TNM-7) in patients with differentiated thyroid carcinoma (DTC). METHODS: The 7th and 8th editions of the TNM staging system were applied to 1613 DTC patients who underwent thyroid surgery between 1996 and 2003...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28635560/sorafenib-in-japanese-patients-with-locally-advanced-or-metastatic-medullary-thyroid-carcinoma-and-anaplastic-thyroid-carcinoma
#2
Yasuhiro Ito, Naoyoshi Onoda, Ken-Ichi Ito, Iwao Sugitani, Shunji Takahashi, Iku Yamaguchi, Koki Kabu, Katsuya Tsukada
BACKGROUND: Therapeutic options for treating advanced or metastatic medullary thyroid carcinoma (MTC) and anaplastic thyroid carcinoma (ATC) are still limited in Japan even though vandetanib for MTC, and lenvatinib for MTC and ATC have been approved. Sorafenib is an oral multikinase inhibitor approved for the treatment of patients with radioactive iodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We conducted an uncontrolled, open-label, multicenter, single-arm, phase 2 clinical study to evaluate the safety and efficacy of sorafenib in Japanese patients with MTC and ATC...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28635520/information-for-clinicians-approach-to-the-patient-with-progressive-radioactive-iodine-refractory-thyroid-cancer-when-to-use-systemic-therapy
#3
Maria Cabanillas, David James Terris, Mona Sabra
N/A.
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28558486/a-higher-ratio-of-estradiol-to-testosterone-is-associated-with-autoimmune-thyroid-disease-in-males
#4
Yi Chen, Yingchao Chen, Fangzhen Xia, Ningjian Wang, Chi Chen, Xiaomin Nie, Qin Li, Bing Han, Hualing Zhai, Boren Jiang, Zhoujun Shen, Yingli Lu
BACKGROUND: Autoimmune thyroid disease (AITD) is highly prevalent. Although AITD is less common in males, it is unclear whether estradiol (E2) combined with total testosterone (T) contributes to the prevalence of AITD. This study evaluated the association between the E2/T ratio and the prevalence of AITD in males. METHODS: The data were obtained from a cross-sectional population-based study, the SPECT-China study, 2014-2015. A total of 4109 males ≥18 years of age were enrolled in this study...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28537531/clinical-features-of-nivolumab-induced-thyroiditis-a-case-series-study
#5
Ichiro Yamauchi, Yoriko Sakane, Yorihide Fukuda, Toshihito Fujii, Daisuke Taura, Masakazu Hirata, Keisho Hirota, Yohei Ueda, Yugo Kanai, Yui Yamashita, Eri Kondo, Masakatsu Sone, Akihiro Yasoda, Nobuya Inagaki
BACKGROUND: The programmed cell death-1 (PD-1) pathway is a novel therapeutic target in immune checkpoint therapy for cancer. It consists of the PD-1 receptor and its two ligands, programmed death-ligand 1 (PD-L1) and programmed death-ligand 2 (PD-L2). Nivolumab is an anti-PD-1 monoclonal antibody approved for malignant melanoma, advanced non-small cell lung cancer, and advanced renal cell carcinoma in Japan. Thyrotoxicosis and hypothyroidism have both been reported in international Phase 3 studies and national post-marketing surveillance of nivolumab in Japan...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28537500/american-thyroid-association-scientific-statement-on-the-use-of-potassium-iodide-ingestion-in-a-nuclear-emergency
#6
Angela M Leung, Andrew J Bauer, Salvatore Benvenga, Alina V Brenner, James V Hennessey, James R Hurley, Stacey A Milan, Arthur B Schneider, Krishnamurthi Sundaram, Daniel J Toft
This document serves to summarize the issues and the American Thyroid Association (ATA) position regarding the use of potassium iodide as a thyroid blocking agent in the event of a nuclear accident. The purpose is to provide a review and updated position statement regarding the advanced distribution, stockpiling, and availability of potassium iodide in the event of nuclear radiation emergencies in the United States.
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28514192/diagnostic-and-treatment-patterns-among-children-adolescents-and-young-adults-with-thyroid-cancer-in-ontario-1992-2010
#7
Jason D Pole, Aleksandra M Zuk, Jonathan D Wasserman
BACKGROUND: Thyroid carcinoma is rare in young children, with a sharp increase in incidence among adolescents and young adults between 15 and 29 years of age. The incidence of thyroid carcinoma is increasing worldwide. Limited prospective population-based data are available to describe diagnostic and treatment practices in this age group. This study undertook a population-based review of thyroid carcinoma among 0- to 29-year-old individuals in Ontario, Canada, utilizing linked administrative data to describe the demographic and care patterns over nearly two decades...
June 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28629253/insights-into-the-management-of-papillary-microcarcinoma-of-the-thyroid
#8
Akira Miyauchi, Yasuhiro Ito, Hitomi Oda
BACKGROUND: Rapid increases in the incidence of thyroid carcinoma with stable mortality rates from thyroid carcinoma have been reported from many countries, and these increases are thought to be due mostly to the increased detection of small papillary thyroid carcinomas (PTCs), including papillary microcarcinomas (PMCs, i.e., PTCs ≤10 mm). Some researchers suggested small PTCs have been overdiagnosed and overtreated. In Japan, the active surveillance of patients with low-risk PMCs was initiated by Kuma Hospital (1993) and Tokyo's Cancer Institute Hospital (1995) based on the extremely higher incidences of both latent thyroid carcinomas in autopsy studies and small PTCs detected in mass screening studies using ultrasound examinations compared to the prevalence of clinical thyroid carcinoma...
June 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614993/a-single-10mg-oral-dose-of-biotin-interferes-with-thyroid-function-tests
#9
Rosa Paula M Biscolla, Maria Izabel Chiamolera, Ina Kanashiro, Rui M B Maciel, Jose Gilberto Henriques Vieira
This letter reports a study with a single 10 mg oral dose of biotin in 19 health subjects. The acute use of biotin interferes with measurement of TSH, free T4 and T3, in a fashion similar to a hyperthyroid subject, and the changes are reversible 24 hours after the biotin ingestion.
June 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614984/tert-promoter-mutations-were-not-found-in-papillary-thyroid-microcarcinomas-that-showed-disease-progression-on-active-surveillance
#10
Tomonori Yabuta, Michiko Matsuse, Mitsuyoshi Hirokawa, Shunichi Yamashita, Norisato Mitsutake, Akira Miyauchi
BACKGROUND: Papillary thyroid carcinoma (PTC) generally has an indolent course, and non-operative management is acknowledged for papillary thyroid microcarcinoma (PTMC). However, some PTMCs progress and we cannot predict future progression at their presentation. BRAF and TERT promoter mutations were recently reported to be associated with poor outcomes of PTC. Here we sought to determine whether these mutations are associated with the progression of PTMCs, toward the goal of predicting progression/nonprogression...
June 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28614983/second-primary-cancer-in-patients-with-differentiated-thyroid-cancer-does-radioiodine-play-a-role
#11
Margarida Silva-Vieira, Sofia Carrilho-Vaz, Susana Esteves, Teresa C Ferreira, Edward Limbert, Lucília Salgado, Valeriano Leite
BACKGROUND: Well Differentiated Thyroid Cancer (WDTC) is the most common endocrine neoplasia and its incidence is rising. Studies have reported an increased risk of Second Primary Cancer (SPC) in WDTC survivors, but its relationship with radioiodine treatment (RAIT) and other risk factors remains controversial. We evaluated whether RAIT is an independent risk factor for SPC in WDTC patients. METHODS: This was a retrospective single-center study. We included 2031 patients with WDTC diagnosed between 1998 and 2009, treated and followed in our reference tertiary cancer center...
June 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28605984/is-the-intrinsic-genomic-activity-of-thyroxine-relevant-in-vivo-insight-from-the-effects-on-gene-expression-in-primary-cerebrocortical-and-neuroblastoma-cells
#12
Pilar Gil-Ibañez, Monica Martin Belinchon, Maria Jesus Obregon, Beatriz Morte, Juan Bernal
BACKGROUND: The possibility that the intrinsic genomic activity of T4 is of physiological relevance has been frequently hypothesized. It might explain the brain gene expression patterns found in type 2-deiodinase (Dio2)-deficient mice. These mice display normal expression of most thyroid hormone-dependent genes despite decreased brain T3. METHODS: The relative effects of T4 and T3 on gene expression were analyzed in mouse neuro-2a (N2a) cells stably expressing the thyroid hormone receptor α1, and in primary mouse cerebrocortical cells enriched in astrocytes or in neurons...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28605303/diagnostic-value-of-circulating-microrna-95-and-190-in-the-differential-diagnosis-of-thyroid-nodules-a-validation-study-in-1000-consecutive-patients
#13
Tania Pilli, Silvia Cantara, Carlotta Marzocchi, Sandro Cardinale, Chiara Santini, Gabriele Cevenini, Furio Pacini
BACKGROUND: It has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy. The present study aimed to validate these results in a larger cohort of patients. MATERIALS AND METHODS: This study prospectively analyzed 1000 patients. Cytological diagnosis was available in 982/1000 (98...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28510505/papillary-thyroid-cancer-the-good-and-bad-of-the-good-cancer
#14
Reese W Randle, Norah M Bushman, Jason Orne, Courtney J Balentine, Elizabeth Wendt, Megan Saucke, Susan C Pitt, Cameron L Macdonald, Nadine P Connor, Rebecca S Sippel
BACKGROUND: Papillary thyroid cancer is often described as the "good cancer" because of its treatability and relatively favorable survival rates. This study sought to characterize the thoughts of papillary thyroid cancer patients as they relate to having the "good cancer." METHODS: This qualitative study included 31 papillary thyroid cancer patients enrolled in an ongoing randomized trial. Semi-structured interviews were conducted with participants at the preoperative visit and two weeks, six weeks, six months, and one year after thyroidectomy...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28393666/does-the-risk-of-metabolic-syndrome-increase-in-thyroid-cancer-survivors
#15
Min-Hee Kim, Jin-Young Huh, Dong-Jun Lim, Moo-Il Kang
BACKGROUND: The steep rise in thyroid cancer observed in recent decades has caused an increase in the population of long-term thyroid cancer survivors. Other than recurrences of cancer, the long-term health consequences of surviving thyroid cancer, particularly metabolic syndrome, have not yet been determined. The aim of this study was to estimate the risk of metabolic syndrome in thyroid cancer survivors. MATERIALS AND METHODS: Population-based data from the Korean National Health and Nutrition Examination Survey (KNHANES) were used for the analysis...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28599614/iodine-contents-in-prenatal-vitamins-in-the-u-s
#16
Sun Y Lee, Alex Stagnaro-Green, Douglas MacKay, Andrea W Wong, Elizabeth N Pearce
No abstract required.
June 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28599610/is-thyroglobulin-a-reliable-marker-of-iodine-status-during-pregnancy
#17
Kostas Markou, Eftychia Koukkou
Not only the utility of serum TSH as an iodine status index in pregnancy is questioned, but also the use of Tg levels as a more useful Iodine Deficiency index, in comparison to UIC, is strongly controversial .
June 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28486081/cost-effectiveness-of-lenvatinib-sorafenib-and-placebo-in-treatment-of-radioiodine-refractory-differentiated-thyroid-cancer
#18
Leslie Wilson, Wei Huang, Linda Chen, Jie Ting, Vicky Cao
BACKGROUND: Lenvatinib (Lenvima(®)) and sorafenib (Nexavar(®)) are the two most recently Food and Drug Administration-approved drugs for treating radioiodine-refractory differentiated thyroid cancer (RR-DTC). Both demonstrated superior progression-free survival over placebo in their respective Phase III clinical trials. This study compared the cost-effectiveness of the two treatments with placebo from a limited societal perspective. METHODS: A Markov model was developed to estimate the costs and health benefits for treatment of RR-DTC...
June 7, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28578598/hyperthyroidism-hypothyroidism-and-cause-specific-mortality-in-a-large-cohort-of-women
#19
Neige My Journy, Marie-Odile Bernier, Michele M Doody, Bruce H Alexander, Martha Linet, Cari Meinhold Kitahara
BACKGROUND: The prevalence of hyperthyroidism and hypothyroidism is 0.5-4% in iodine-replete communities, but 5-10 times higher in women than men. Those conditions are associated with a broad range of metabolic disorders and cardiovascular diseases. Biological evidence of a role of thyroid hormones in carcinogenesis also exists. However, the association between thyroid dysfunction and cardiovascular disease or cancer mortality risk remains controversial. In a large cohort of women, we evaluated the associations of hyperthyroidism and hypothyroidism with cause-specific mortality after nearly 30 years of follow-up...
June 3, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28578595/thymic-hyperplasia-associated-with-graves-disease-pathophysiology-and-proposed-management-algorithm
#20
Uzma Haider, Patrick Richards, Andrew Gianoukakis
BACKGROUND: The association between Graves' disease (GD) and thymic hyperplasia was first described in 1912 and has been reported numerous times thereafter. Thymic hyperplasia associated with GD presents as an incidental mediastinal mass on chest X- ray or Computerized tomography (CT). The pathogenesis of thymic hyperplasia in the setting of GD is unclear but seems to involve a complex interplay of hormonal and immunological mechanisms. SUMMARY: Here we have reviewed the effect that thyroid hormones and autoimmunity have on thymic growth and size...
June 3, 2017: Thyroid: Official Journal of the American Thyroid Association
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