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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/29325506/clinical-impact-of-detectable-antithyroglobulin-antibodies-below-the-reference-limit-borderline-in-patients-with-papillary-thyroid-carcinoma-with-negative-serum-thyroglobulin-and-neck-ultrasonography-after-ablation-a-prospective-study
#1
Marina Carvalho, Pedro Weslley Rosario, Gabriela Franco Mourão, Luis Fernando Faria Oliveira, Maria Regina Calsolari
BACKGROUND: Interference of antithyroglobulin antibodies (TgAb) with serum thyroglobulin (Tg) can occur even at detectable TgAb concentrations below the reference limit (borderline TgAb). Thus, borderline TgAb is considered positive TgAb in patients with thyroid cancer. This prospective study evaluated patients with papillary thyroid carcinoma with negative Tg and neck ultrasonography (US) after initial therapy and compared tumor persistence/recurrence and long-term Tg and TgAb behavior in those with borderline versus undetectable TgAb...
January 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29325496/maternal-thyrotropin-receptor-antibody-concentration-and-the-risk-of-fetal-and-neonatal-thyrotoxicosis-a-systematic-review
#2
Myrthe Marguerite van Dijk, Iris Smits, Eric Fliers, Peter H Bisschop
BACKGROUND: In pregnant women with Graves' disease, maternal thyrotropin receptor antibodies (TRAb) can cross the placenta and induce fetal or neonatal thyrotoxicosis. Symptoms of fetal thyrotoxicosis are tachycardia, intrauterine growth restriction and intra-uterine death. Recommendations on an upper limit of TRAb concentrations below which intensive fetal monitoring can be safely omitted vary between different guidelines. The objective of this study was to define an evidence-based cut-off level for maternal TRAb necessitating additional fetal monitoring during pregnancy...
January 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29320965/alterations-of-the-gut-microbiota-in-hashimoto-s-thyroiditis-patients
#3
Fuya Zhao, Jing Feng, Jun Li, Lei Zhao, Yang Liu, Huinan Chen, Ye Jin, Biqiang Zhu, Yunwei Wei
BACKGROUND: Hashimoto's thyroiditis (HT) is an organ-specific autoimmune disease in which both genetic predisposition and environmental factors serve as disease triggers. Many studies have indicated that alterations in the gut microbiota are important environmental factors in the development of inflammatory and autoimmune diseases. We systematically performed a comparative analysis of the gut microbiota in HT patients and healthy controls. METHODS: We first conducted a cross-sectional study of 28 HT patients and 16 matched healthy controls...
January 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29316865/effects-of-thyroid-stimulating-hormone-on-peripheral-thyroid-hormone-metabolism-and-serum-lipids
#4
Carolien M Beukhof, Elske Theresia Massolt, Theo J Visser, Tim Korevaar, Marco Medici, Wouter W de Herder, Jeanine Roeters van Lennep, Monique Mulder, Yolanda B de Rijke, Christoph Reiners, Frederik A Verburg, Robin Peeters
BACKGROUND: Subclinical hypothyroidism is associated with dyslipidemia and atherosclerosis. Whether part of these effects are mediated via direct effects of TSH on peripheral TH metabolism and/or concentrations of serum lipids is not clear. OBJECTIVE: To examine whether thyroid stimulating hormone (TSH) has direct effects on peripheral thyroid hormone (TH) metabolism and serum lipids. METHODS: We retrospectively analyzed 82 patients with differentiated thyroid cancer...
January 9, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29310524/the-iconography-of-goiter-five-sculptures-in-italian-sacred-mountains-varallo-orta-and-varese
#5
Gianlorenzo Dionigi, Renzo Dionigi
Many of the representations of individuals with goiters reported in the literature actually refer to occasional swelling of the anterior neck, or "pseudogoiter", the artists not having any plan to expose this pathology. The article describes five representations of goiters, as observed by the authors in the sculptures of the Sacred Mountains of Varallo, Orta and Varese (Italy). They are classical and appropriate examples of the iconography of ''real goiter,'' since in these cases the sculptors had the definite aim to show persons with goiter...
January 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29179638/the-hobnail-variant-of-papillary-thyroid-carcinoma-clinical-molecular-characteristics-of-a-large-monocentric-series-and-comparison-with-conventional-histotypes
#6
Sara Watutantrige-Fernando, Federica Vianello, Susi Barollo, Loris Bertazza, Francesca Galuppini, Elisabetta Cavedon, Simona Censi, Clara Benna, Eric Casal Ide, Alessandro Parisi, Davide Nacamulli, Maurizio Iacobone, Gianmaria Pennelli, Caterina Mian
BACKGROUND: The hobnail variant of papillary thyroid carcinoma (HPTC) has an aggressive behavior. The aims of this prospective study were to define the clinical/molecular characteristics of HPTC, and to compare them to those of conventional papillary thyroid carcinoma (PTC). METHODS: From 2010 to 2016, 25 cases of HPTC, characterized clinically and molecularly (BRAF, RAS, TERT promoter, and TP53 mutations), were compared to a series of 165 consecutive cases of PTC...
January 2, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29281951/gene-fusions-in-thyroid-cancer
#7
Valentina D Yakushina, Larisa V Lerner, Alexander V Lavrov
Gene fusions are known in many cancers as driver or passenger mutations. They play an important role in both etiology and pathogenesis of cancer and are considered as potential diagnostic and prognostic markers and possible therapeutic targets. Spectrum and prevalence of gene fusions in thyroid cancer ranges from single cases up to 80% depending on specific type of cancer. During last three years massive parallel sequencing technologies revealed new fusions and allowed detailed characteristics of fusions in different types of thyroid cancer...
December 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29160164/rutin-scavenges-reactive-oxygen-species-inactivates-5-adenosine-monophosphate-activated-protein-kinase-and-increases-sodium-iodide-symporter-expression-in-thyroid-pccl3-cells
#8
Carlos Frederico Lima Gonçalves, Mariana Lopes de Freitas, Rodrigo Soares Fortunato, Leandro Miranda-Alves, Denise P Carvalho, Andrea Claudia Freitas Ferreira
BACKGROUND: Thyroid iodide uptake, mediated by the sodium-iodide symporter (NIS), is essential for thyroid hormone synthesis and also for treatment of thyroid diseases, such as thyroid cancer, through radioiodine therapy. Therefore, compounds able to increase thyroid iodide uptake could be clinically useful, and it is of great importance to unravel the mechanisms underlying such an effect. It has been shown previously that the flavonoid rutin increases thyroid radioiodide uptake in vivo in rats...
December 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29160163/cancer-risk-associated-with-nuclear-atypia-in-cytologically-indeterminate-thyroid-nodules-a-systematic-review-and-meta-analysis
#9
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Susan C Sharpe, Valentina D Tarasova, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Bruce M Wenig, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting nuclear atypia have a higher risk of malignancy. This study aimed to assess whether cytologically indeterminate thyroid nodules with nuclear atypia have a significantly higher cancer risk than those without nuclear atypia...
December 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29258382/efficacy-of-a-home-based-exercise-program-after-thyroidectomy-for-thyroid-cancer-patients
#10
Kyung Hee Kim, Mee Ock Gu, Junghwa Jung, Jong Ryeal Hahm, Soo Kyoung Kim, Jin Hyun Kim, Seung Hoon Woo
BACKGROUND: The objective of this study was to determine the effect of a home-based exercise program on fatigue, anxiety, quality of life, and immune function of thyroid cancer patients taking thyroid hormone replacement after thyroidectomy. METHOD: This quasi-experimental study with a non-equivalent control group included 43 outpatients taking thyroid hormone replacement after thyroidectomy (22 in experimental group and 21 in control group). After education about the home-based exercise program, subjects in the experimental group underwent 12 weeks of aerobic, resistance, and flexibility exercise...
December 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29256827/reassessment-of-differentiated-thyroid-cancer-patients-using-the-8th-tnm-classification-system-a-comparative-study
#11
Miriam Steinschneider, Limor Muallem Kalmovich, Shlomit Koren, Karen Or, Dror Cantrell, Carlos Benbassat
INTRODUCTION: Facing the prevailing concept that increased diagnosis with no change in mortality drives the increased incidence of differentiated thyroid cancer (DTC), considerable modifications have been introduced in the new TNM/AJCC staging system edition. AIMS: To compare a group of DTC patients before and after re-staging, by mortality, disease severity, and disease outcome. METHODS: We restaged DTC patients (N = 433) according to the 8th edition and compared the results to the 7th edition for clinicopathological data, treatment modalities, and disease outcome...
December 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29212434/stable-isotope-pharmacokinetic-studies-provide-insight-into-effects-of-age-sex-and-weight-on-levothyroxine-metabolism
#12
Islam Younis, Mariam A Ahmed, Kenneth D Burman, Offie P Soldin, Jacqueline Jonklaas
Background We wished to determine whether levothyroxine pharmacokinetics (PKs) are affected by age, weight, and sex. Methods A pharmacokinetic study was performed after administration of a tracer dose of carbon-13- labeled LT4 (13C-LT4). The study was conducted at an academic medical center. Adults of any age being treated with levothyroxine for hypothyroidism were enrolled in the study. A single dose of 13C- LT4 was administered. Eighteen serial plasma samples were collected. One sample was obtained before the 13C- LT4 dose and the majority of the remaining samples were collected over the 120-hour period post-dosing...
December 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29205104/coup-tf1-modulates-thyroid-hormone-action-in-an-embryonic-stem-cell-model-of-cortical-pyramidal-neuronal-differentiation
#13
Xiaochun Teng, Yan-Yun Liu, Weiping Teng, Gregory A Brent
BACKGROUND: Thyroid hormone is critical for normal brain development and acts in a spatial and temporal specific pattern. Thyroid hormone excess, or deficiency, can lead to irreversible impairment of brain and sensory development. COUP-TF1, expressed early in neuronal development, is essential to achieve normal brain structure. Thyroid hormone stimulation of gene expression is inversely correlated with the level of COUP-TF1 expression. METHODS: We utilized an in vitro method of differentiating mouse embryonic stem (mES) cells into cortical neurons to study the influence of COUP-TF1 on thyroid hormone signaling in brain development...
December 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29205102/crispr-cas9-editing-of-the-mouse-thra-gene-produces-models-with-variable-resistance-to-thyroid-hormone
#14
Suzy Markossian, Romain Guyot, Sabine Richard, Marie Teixeira, Nadine Aguilera, Mathilde Bouchet, Michelina Plateroti, Wenyue Guan, Karine Gauthier, Denise Aubert, Frederic Flamant
Resistance to thyroid hormone due to THRA mutations (RTHα) is a recently discovered genetic disease, displaying important variability in its clinical presentation. The mutations alter the function of TRα1, one of the two nuclear receptors for thyroid hormone. Our aim was to understand the relationship between specific THRA mutations and phenotype. We used CRISPR/Cas9 genome editing to generate 5 new mouse models of RTHα, with frameshift or missense mutations. Like human patients, mutant mice displayed a hypothyroid-like phenotype, with altered development...
December 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29117854/nodal-factors-predictive-of-recurrence-after-thyroidectomy-and-neck-dissection-for-papillary-thyroid-carcinoma
#15
Sung Hoon Nam, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Lymph node (LN) yield and ratio are considered important predictors of post-treatment outcomes for several human cancers. This study examined the association between nodal factors, including the LN yield and ratio, with recurrence after thyroidectomy plus central compartment neck dissection (ND) for papillary thyroid carcinoma (PTC). MATERIALS AND METHODS: This retrospective study involved 2384 consecutive patients who underwent a thyroidectomy plus central compartment ND combined with (n = 440) or without lateral compartment ND at the authors' tertiary referral center between 2006 and 2012...
December 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29183262/globus-symptoms-in-patients-undergoing-thyroidectomy-relationships-with-psychogenic-factors-thyroid-disease-and-surgical-procedure
#16
Chisato Tomoda, Kiminori Sugino, Tomoaki Tanaka, Yuna Ogimi, Chie Masaki, Junko Akaishi, Kiyomi Yamada Hames, Akifumi Suzuki, Kenichi Matsuzu, Takashi Uruno, Keiko Ohkuwa, Wataru Kitagawa, Mitsuji Nagahama, Koichi Ito
INTRODUCTION: The number of patients who need thyroid surgery has increased worldwide in recent decades. Patients with thyroid disease experience globus pharyngeus as a result of direct compression and edema of surrounding organs. Thyroid surgery is needed to improve these symptoms or as treatment for thyroid cancer. After thyroid surgery, globus symptoms may become worse and may affect the daily life of the patient for a long time. Psychogenic problems have also been thought to cause the globus sensation...
November 28, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29179646/practical-initial-risk-stratification-based-on-lymph-node-metastases-in-pediatric-and-adolescent-differentiated-thyroid-cancer
#17
MinJi Jeon, Young Nam Kim, Tae-Yon Sung, Suck Joon Hong, Yoon Young Cho, Tae Yong Kim, YoungKee Shong, Won Bae Kim, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim, Won Gu Kim
BACKGROUND: Data on the risk stratification of pediatric differentiated thyroid cancer (DTC) remain scarce. We aimed to evaluate the predictors of structural persistent/recurrent disease and revise an initial risk stratification system in pediatric DTC patients. METHODS: This retrospective cohort study included 203 patients (< 20 years) from two tertiary referral centers in Korea. We classified the extent of cervical lymph node (LN) metastasis based on the location or number of metastatic LNs...
November 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29179642/a-follow-up-strategy-for-patients-with-excellent-response-to-initial-therapy-for-differentiated-thyroid-carcinoma-less-is-better
#18
MinJi Jeon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Tae Yong Kim, Won Bae Kim, YoungKee Shong, Won Gu Kim
BACKGROUND: The risk of recurrence in patients with differentiated thyroid cancer (DTC) can be estimated based on their response to initial therapy. The aim of this study is to evaluate adequate follow-up strategy for DTC patients with excellent response by assessing the characteristics of structural recurrence. METHODS: This historical cohort study included 1359 DTC patients who had excellent response to initial therapy after total thyroidectomy with radioactive iodine remnant ablation...
November 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29048237/lenvatinib-for-the-treatment-of-radioiodine-refractory-thyroid-cancer-in-real-life-practice
#19
Amandine Berdelou, Isabelle Borget, Yann Godbert, Thierry Nguyen, Marie-Eve Garcia, Cécile N Chougnet, Aurélie Ferru, Camille Buffet, Olivier Chabre, Olivier Huillard, Sophie Leboulleux, Martin Schlumberger
BACKGROUND: In the Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT) phase 3 trial on advanced radioactive iodine-refractory differentiated thyroid cancer (rDTC), lenvatinib improved median progression-free survival over placebo by almost 15 months and induces an objective response rate of 64.8%, but adverse events occurred in almost all patients. The present study evaluates the efficacy and toxicity of lenvatinib treatment in real-life practice. METHODS: Clinical charts of 88 consecutive patients treated with lenvatinib from July 2015 to June 2016 in 27 French centers were retrospectively reviewed...
November 27, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29161986/real-world-experience-with-targeted-therapy-for-the-treatment-of-anaplastic-thyroid-carcinoma
#20
Priyanka Iyer, Ramona Dadu, Renata Ferrarotto, Naifa Busaidy, Mouhammed Amir Habra, Mark Zafereo, Neil D Gross, Kenneth Hess, Maria Gule-Monroe, Michelle D Williams, Maria Cabanillas
BACKGROUND: Patients with anaplastic thyroid cancer (ATC) have a dismal prognosis despite systemic cytotoxic chemotherapy. Our objective was to study the efficacy and safety of targeted therapy in ATC patients when used outside of a clinical trial. METHODS: This is a retrospective review from April 2015 to May 2016 at a single academic institution where we studied 16 ATC patients receiving targeted therapy outside of a clinical trial. Ten patients (8 BRAF wild-type and 2 BRAF V600E mutant) were started on lenvatinib and 6 with BRAF V600E mutated tumors received the combination of dabrafenib plus trametinib...
November 22, 2017: Thyroid: Official Journal of the American Thyroid Association
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