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Thyroid: Official Journal of the American Thyroid Association

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https://www.readbyqxmd.com/read/28922977/no-direct-evidence-for-igf-1-receptor-igf-1r-stimulating-antibodies-in-graves-orbitopathy
#1
Marvin C Gershengorn
NA.
September 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28791920/detection-of-malignancy-among-suspicious-thyroid-nodules-1%C3%A2-cm-on-ultrasound-with-various-thyroid-image-reporting-and-data-systems
#2
Su Min Ha, Jae Kyun Kim, Jung Hwan Baek
BACKGROUND: In patients undergoing active surveillance of papillary thyroid microcarcinoma, definitive therapy-usually preceded by a definitive diagnostic procedure-is not recommended until evidence of disease progression is obtained, as stated in the American Thyroid Association guidelines. This is because the deferring of definitive diagnosis and therapy until disease progression has no impact on the disease-specific survival. This study evaluated the malignancy rate and probability of thyroid nodules, which was further stratified based on the size cutoff value of 1 cm, with suspicious findings on ultrasonography (US), by using various malignant stratification systems...
September 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#3
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28920531/role-of-kr%C3%A3-ppel-like-factor-4-in-the-maintenance-of-chemoresistance-of-anaplastic-thyroid-cancer
#4
Su In Lee, Dae Kyoung Kim, Eun Jin Seo, Eun Jung Choi, Yang Woo Kwon, Il Ho Jang, Jin Choon Lee, Hyun Yul Kim, Minho Shong, Jae Ho Kim, Seong-Jang Kim
BACKGROUND: Anaplastic thyroid cancer (ATC) has a very poor prognosis due to its aggressive nature and resistance to conventional treatment. Radiotherapy and chemotherapy are not fully effective because of the undifferentiated phenotype and enhanced drug resistance of ATC. The objective of this study was to evaluate the involvement of Krüppel-like factor 4 (KLF4), a stemness-associated transcription factor, in the undifferentiated phenotype and drug resistance of ATC. METHODS: ATC cells were compared with papillary thyroid cancer cells in drug resistance and gene expression...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28793848/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-may-exclude-malignancy-in-sonographically-suspicious-and-scintigraphically-hypofunctional-thyroid-nodules-and-reduce-unnecessary-thyroid-surgeries
#5
Marcus Ruhlmann, Jürgen Ruhlmann, Rainer Görges, Ken Herrmann, Gerald Antoch, Hans-Wilhelm Keller, Verena Ruhlmann
BACKGROUND: The aim of this study was to evaluate whether (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is useful in the further characterization of sonographically suspicious and scintigraphically hypofunctional thyroid nodules. METHODS: Sixty-five patients with sonographically suspicious thyroid nodules that were hypofunctional on 99m-Tc-pertechnetate scintigraphy (diameter >1 cm) were retrospectively analyzed. All patients underwent evaluation with FDG-PET/CT...
September 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28791924/comparison-of-core-needle-biopsy-and-fine-needle-aspiration-for-evaluating-thyroid-incidentalomas-detected-by-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-a-propensity-score-analysis
#6
Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
BACKGROUND: This study used a propensity score analysis to assess the roles of core-needle biopsy (CNB) and fine-needle aspiration (FNA) in the evaluation of thyroid incidentalomas detected on (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT). METHODS: The study population was obtained from a historical cohort who underwent (18)F-FDG PET/CT between October 2008 and September 2015. Patients were included who underwent ultrasound-guided CNB or FNA for incidental focal uptake of (18)F-FDG in the thyroid gland on PET/CT...
September 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28699478/long-term-antithyroid-drug-treatment-a-systematic-review-and-meta-analysis
#7
Fereidoun Azizi, Ramin Malboosbaf
BACKGROUND: Several studies have reported inconsistent findings on the advantages and disadvantages of long-term treatment with antithyroid drugs (ATD). A systematic review and meta-analysis was undertaken to clarify the numerous aspects of long-term treatment with ATD. METHODS: Medline and the Cochrane Library for trials published between 1950 and May 2016 were systematically searched. Studies containing data for long-term (>24 months) ATD treatment were included...
September 15, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28806882/long-term-outcomes-of-lateral-neck-dissection-in-patients-with-recurrent-or-persistent-well-differentiated-thyroid-cancer
#8
Steven B Chinn, Mark E Zafereo, Steven G Waguespack, Beth S Edeiken, Dianna B Roberts, Gary L Clayman
BACKGROUND: Well-differentiated thyroid carcinoma (WDTC) has a high predilection for regional metastatic spread. Rates for WDTC lateral neck recurrence are reported to be as high as 24% in patients after initial thyroidectomy, lateral neck surgery, and adjuvant radioactive (RAI) iodine treatment. The objective of the study was to evaluate the efficacy, safety, and long-term outcome of comprehensive lateral neck dissection (LND) of levels II-V for recurrent or persistent WDTC in a tertiary referral center...
September 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28806881/cancer-risk-stratification-of-indeterminate-thyroid-nodules-a-cytological-approach
#9
Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Marino E Leon, Kristen J Otto, Julie E Hallanger-Johnson, J Trad Wadsworth, Bruce M Wenig, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: Management recommendations for thyroid nodules rely primarily on the cytological diagnosis. However, 25% of biopsies render an indeterminate cytology for which management decision is more challenging due to heterogeneity of the specimens. This study aimed to stratify the cancer risk through subcategorization of indeterminate cytology. METHODS: The indeterminate cytological specimens (Bethesda-III or IV) of 518 thyroid nodules consecutively evaluated at our academic cancer center between October 2008 and September 2015, blinded to the histological outcome, were retrospectively reviewed...
September 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28806880/temporal-changes-in-thyroid-nodule-volume-lack-of-effect-on-paranodular-thyroid-tissue-volume
#10
Giorgio Grani, Rocco Bruno, Giuseppe Lucisano, Giuseppe Costante, Domenico Meringolo, Efisio Puxeddu, Massimo Torlontano, Salvatore Tumino, Marco Attard, Livia Lamartina, Antonio Nicolucci, David S Cooper, Sebastiano Filetti, Cosimo Durante
BACKGROUND: The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue. METHODS: Eight Italian thyroid-disease referral centers enrolled 992 consecutive patients with one to four benign nodules...
September 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28899229/thyroid-storm-a-japanese-perspective
#11
Takashi Akamizu
BACKGROUND: Thyroid storm (TS) is life threatening. In the mid-2000s, its incidence was poorly defined, peer-reviewed diagnostic criteria were not available, and management and treatment did not seem to be verified based upon evidence and latest advances in medicine. METHODS: We first developed diagnostic criteria based on 99 patients in the literature and our 7 patients. We then conducted initial and follow-up surveys from 2004 through 2008, targeting all hospitals in Japan to obtain and verify information on patients who met diagnostic criteria for TS...
September 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28891405/projecting-survival-in-papillary-thyroid-cancer-a-comparison-of-the-7th-and-8th-editions-of-the-ajcc-uicc-staging-systems-in-two-contemporary-national-patient-cohorts
#12
Lauren N Pontius, Taofik O Oyekunle, Samantha Thomas, Michael Stang, Randall P Scheri, Sanziana Roman, Julie Ann Sosa
BACKGROUND: This study aims to compare the 7th and 8th editions of the AJCC/UICC TNM staging system for patients with papillary thyroid cancer (PTC) in two national patient cohorts. METHODS: Adult PTC patients undergoing surgery were selected from SEER (2004-2012) and NCDB (2004-2012). Staging criteria for the 7th and 8th AJCC/UICC editions were applied separately to both cohorts; survival probabilities were estimated using the Kaplan-Meier method. Multivariable Cox proportional hazards models were used to estimate the association of stage with survival in both settings...
September 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28891394/the-role-of-chemokines-in-thyroid-carcinoma
#13
Sharinie Yapa, Omar Mulla, Victoria Green, James England, John Greenman
Global incidence of thyroid cancer is increasing and metastatic spread to lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process involving invasion, angiogenesis, cell trafficking, extravasation, organ specific homing and growth. A key aspect in this process involves a multitude of interactions between chemokines and their receptors. Chemokines are a group of small proteins, which act to elicit normal physiological and immune responses principally through recruitment of specific cell populations to site of infection or malignancy...
September 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28891392/-i-esr2-i-gene-and-medullary-thyroid-carcinoma
#14
Macarena Ruiz-Ferrer, Raquel M Fernández, Elena Navarro, Guillermo Antinolo, Salud Borrego
Not required for a letter to the editor.
September 11, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28874095/seasonal-rhythms-the-role-of-thyrotropin-and-thyroid-hormones
#15
Tomoya Nakayama, Takashi Yoshimura
Seasonal changes in various physiological events have been reported in humans including metabolism, immune function, and mood. However, the molecular and endocrine basis of the seasonal changes remain unclear. Animals that breed seasonally such as, the Japanese quail and Siberian hamster have sophisticated seasonal mechanisms and provide excellent opportunities to understand the underlying processes. Functional genomic analysis of the quail uncovered the photoperiodic signal transduction pathway, which regulates avian seasonal reproduction: Long day stimulus induces secretion of the thyroid-stimulating hormone (TSH) from the pars tuberalis (PT) of the anterior pituitary gland...
September 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28874092/anxiety-and-fear-of-recurrence-despite-a-good-prognosis-an-interview-study-with-differentiated-thyroid-cancer-patients
#16
Christel Hedman, Peter Strang, Therese Djärv, Ida Widberg, Catharina Ihre Lundgren
BACKGROUND: Despite a good prognosis, fear of recurrence is prevalent even several years after a diagnosis of differentiated thyroid cancer (DTC). For this reason, our aim was to make an in-depth exploration of anxiety, sources of anxiety, and protective strategies. METHODS: In order to capture a broad description of the phenomenon, a purposeful, maximum variation sampling strategy regarding age, gender, stage of disease, educational level and time since diagnosis was used...
September 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28747092/clinical-features-of-a-family-with-multiple-endocrine-neoplasia-type-2a-caused-by-the-d631y-ret-mutation
#17
Naykky Singh Ospina, Spyridoula Maraka, Diane Donegan, John C Morris
We describe a family with multiple endocrine neoplasia type 2A (MEN2A) caused by the D631Y RET mutation resulting in an atypical phenotype. The index case was a 24-year-old man with history of recurrent anaplastic ependymoma incidentally found to have the D631Y RET mutation. At first assessment, four family members had evidence of large pheochromocytomas. One patient was found to have micromedullary thyroid cancer at 79 years of age. None of the patients had primary hyperparathyroidism. Patients with MEN2A caused by a D631Y RET mutation most commonly present with pheochromocytomas...
September 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28859553/thyroid-nodule-diagnostic-markers-in-the-face-of-the-new-diagnosis-nift-p-time-for-a-reset
#18
Zeyad T Sahli, Christopher B Umbricht, Eric B Schneider, Martha A Zeiger
Current thyroid molecular tests are specifically designed for the differential diagnosis of nodules with indeterminate or suspicious fine needle aspiration (FNA) cytology. However, their clinical validity faces challenges from both variation among institutions in cancer prevalence and, most recently, the new category of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P). The latter diagnosis was previously classified as malignant. Relevant to this, all molecular panels on the market today were originally tested and validated within the context of these entities being considered malignant...
August 31, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28859548/recovery-of-3-iodothyronamine-and-derivatives-in-biological-matrices-problems-and-pitfalls
#19
Leonardo Lorenzini, Sandra Ghelardoni, Alessandro Saba, Ginevra Sacripanti, Grazia Chiellini, Riccardo Zucchi
BACKGROUND: Difficulties have been reported in quantitating 3-iodothyronamine (T1AM) in blood or serum, and tentatively attributed to problems in extraction or other pre-analytical steps. For this reason even cell culture experiments have often be performed with unphysiological protein-free media. The aim of this study was to evaluate the recovery of exogenous T1AM added to a standard cell culture medium, namely DMEM supplemented with fetal bovine serum (FBS), and to other biological matrices...
August 31, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28854871/unstable-thyroid-function-in-older-adults-is-caused-by-alterations-in-both-thyroid-and-pituitary-physiology-and-associated-with-increased-mortality
#20
Jennifer Sophie Mammen, John McGready, Paul W Ladenson, Eleanor M Simonsick
BACKGROUND: Average thyrotropin (TSH) levels are known to be higher in older adults when measured in cross-sectional populations. Possible etiologies include differential survival, neutral aging changes, or increased disease prevalence at older ages. This study aimed to elucidate the mechanisms underlying changing thyroid function during aging, and to determine the association of changes with survival, by analyzing the individual thyroid axis over time. METHODS: Individual patterns of changing TSH and free thyroxine (FT4) were determined in 640 participants in the Baltimore Longitudinal Study of Aging who had at least three measures of serum TSH and FT4, not on medications, over an average of 7 years follow up...
August 30, 2017: Thyroid: Official Journal of the American Thyroid Association
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