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Glycobiology

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https://www.readbyqxmd.com/read/28204532/characterization-of-the-single-subunit-oligosaccharyltransferase-stt3a-from-trypanosoma-brucei-using-synthetic-peptides-andlipid-linked-oligosaccharide-analogs
#1
Ana S Ramírez, Jérémy Boilevin, Rasomoy Biswas, Bee Ha Gan, Daniel Janser, Markus Aebi, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher
No abstract text is available yet for this article.
February 15, 2017: Glycobiology
https://www.readbyqxmd.com/read/28204496/the-glycan-specific-sulfotransferase-r77w-galnac-4-st1-putatively-responsible-for-peeling-skin-syndrome-has-normal-properties-consistent-with-a-simple-sequence-polymorphisim
#2
Dorothy Fiete, Yiling Mi, Mary Beranek, Nancy L Baenziger, Jacques U Baenziger
No abstract text is available yet for this article.
February 15, 2017: Glycobiology
https://www.readbyqxmd.com/read/28204489/enzymatic-properties-of-a-gh19-chitinase-isolated-from-rice-lacking-a-major-loop-structure-involved-in-chitin-binding
#3
Jun Tanaka, Tamo Fukamizo, Takayuki Ohnuma
No abstract text is available yet for this article.
February 15, 2017: Glycobiology
https://www.readbyqxmd.com/read/28186556/discoveries-of-the-structures-of-sialic-acid-and-cmp-sialic-acid-1957-1960-a-letter-from-saul-roseman
#4
Ronald L Schnaar, Yuan C Lee
No abstract text is available yet for this article.
February 9, 2017: Glycobiology
https://www.readbyqxmd.com/read/28168306/characterization-of-a-mycobacterial-cellulase-and-its-impact-on-biofilm-and-drug-induced-cellulose-production
#5
Niël Van Wyk, David Navarro, Mickaël Blaise, Jean-Guy Berrin, Bernard Henrissat, Michel Drancourt, Laurent Kremer
No abstract text is available yet for this article.
February 7, 2017: Glycobiology
https://www.readbyqxmd.com/read/28173134/non-reducing-end-labeling-of-heparan-sulfate-via-click-chemistry-and-a-high-throughput-elisa-assay-for-heparanase
#6
Zhengliang L Wu, Xinyi Huang, Cheryl M Ethen, Timothy Tatge, Marta Pasek, Joseph Zaia
No abstract text is available yet for this article.
February 6, 2017: Glycobiology
https://www.readbyqxmd.com/read/28158578/introducing-transgalactosylation-activity-into-a-family-42-%C3%AE-galactosidase
#7
Andrea Strazzulli, Beatrice Cobucci-Ponzano, Sara Carillo, Emiliano Bedini, Maria Michela Corsaro, Gabriella Pocsfalvi, Stephen G Withers, Mosè Rossi, Marco Moracci
No abstract text is available yet for this article.
February 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28138013/hyaluronan-synthase-assembles-hyaluronan-on-a-glcnac-%C3%AE-1-4-n-glcnac-%C3%AE-1%C3%A2-udp-primer-and-hyaluronan-retains-this-residual-chitin-oligomer-as-a-cap-at-the-nonreducing-end
#8
Paul H Weigel, Bruce A Baggenstoss, Jennifer L Washburn
Class I hyaluronan synthases (HAS) assemble [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP at the reducing end and also make chitin. Streptococcus equisimilis HAS (SeHAS) also synthesizes chitin-UDP oligosaccharides, (GlcNAc-β1,4)n-GlcNAc(α1→)UDP (Weigel et al Glycobiol. 25, 632-643, 2015). Here we determined if HAS uses chitin-UDPs as primers to initiate HA synthesis, leaving the non-HA primer at the nonreducing (NR) end. HA made by SeHAS membranes was purified, digested with streptomyces lyase, and hydrophobic oligomers were enriched by solid phase extraction and analyzed by MALDI-TOF MS...
January 30, 2017: Glycobiology
https://www.readbyqxmd.com/read/28130266/a-potential-role-for-chondroitin-sulfate-dermatan-sulfate-in-arm-regeneration-in-amphiura-filiformis
#9
Rashmi Ramachandra, Ramesh B Namburi, Sam T Dupont, Olga Ortega-Martinez, Toin H van Kuppevelt, Ulf Lindah, Dorothe Spillmann
Glycosaminoglycans (GAGs), such as chondroitin sulfate (CS) and dermatan sulfate (DS) from various vertebrate and invertebrate sources are known to be involved in diverse cellular mechanisms during repair and regenerative processes. Recently, we have identified CS/DS as the major GAG in the brittlestar Amphiura filiformis, with high proportions of di- and tri-O-sulfated disaccharide units. As this echinoderm is known for its exceptional regeneration capacity, we aimed to explore the role of these GAG chains during A...
January 27, 2017: Glycobiology
https://www.readbyqxmd.com/read/28122822/intestinal-muc2-mucin-o-glycosylation-is-affected-by-microbiota-and-regulated-by-differential-expression-of-glycosyltranferases
#10
Liisa Arike, Jessica Holmén-Larsson, Gunnar C Hansson
Intestinal cells are covered by mucus. In the small intestine, a single unattached mucus is present whereas the colon has both an inner attached mucus layer and an outer loose mucus. The attached mucus of the colon is impenetrable to bacteria while the loose mucus acts as a habitat for commensal bacteria. In germ-free (GF) mice, small intestinal mucus is attached to the epithelium and the inner colon mucus is penetrable. O-glycosylation plays an important role in the host-microbiota interactions as the commensal bacteria use glycans as nutrient sources and attachment sites...
January 24, 2017: Glycobiology
https://www.readbyqxmd.com/read/28115423/role-of-selectins-and-their-ligands-in-human-implantation-stage
#11
REVIEW
Ying Feng, Xue Ma, Liwen Deng, Bin Yao, Ying Xiong, Yilun Wu, Lin Wang, Qianhong Ma, Fang Ma
Selectins are a family of calcium-dependent, type I transmembrane, carbohydrate-binding glycoproteins. Selectins and their ligands are not only involved in physiological processes such as leukocyte homing and pathological processes such as cancer, but also play an essential role in the human implantation. L-selectin and its ligands participate in the adhesion of the blastocyst to the endometrium at the maternal-fetal interface. P-selectin and E-selectin are involved in immune recognition of maternal decidua to the embedded embryo as well as trophoblast migration within decidual spiral arterioles...
January 23, 2017: Glycobiology
https://www.readbyqxmd.com/read/28104787/binding-characteristics-of-galectin-3-fusion-proteins
#12
Sophia Böcker, Lothar Elling
Galectin-3 modulates cell adhesion and signaling events by specific binding and cross-linking galactoside containing carbohydrate ligands. Proteolytic cleavage by metalloproteinases yields in vivo N-terminally truncated galectin-3 still bearing the carbohydrate recognition domain. Truncated galectin-3 has been demonstrated to act in vivo as a negative inhibitor of galectin-3 due to higher affinity for carbohydrate ligands. We here present our studies on a series of twelve human galectin-3 protein constructs...
January 19, 2017: Glycobiology
https://www.readbyqxmd.com/read/28104786/identification-of-a-chondroitin-synthase-from-an-unexpected-source-the-green-sulfur-bacterium-chlorobium-phaeobacteroides
#13
Dixy E Green, Paul L DeAngelis
Glycosaminoglycans [GAGs] are known to be present in all animals as well as some pathogenic microbes. Chondroitin sulfate is the most abundant GAG in mammals where it has various structural and adhesion roles. The Gram-negative bacteria Pasteurella multocida Type F and Escherichia coli K4 produce extracellular capsules composed of unsulfated chondroitin or a fructosylated chondroitin, respectively. Such polysaccharides that are structurally related to host molecules do not generally provoke a strong antibody response thus are thought to be employed as molecular camouflage during infection...
January 19, 2017: Glycobiology
https://www.readbyqxmd.com/read/28100567/mecp2-regulated-glycogenes-contribute-to-proliferation-and-apoptosis-of-gastric-cancer-cells
#14
Yannan Qin, Lingyu Zhao, Xiaofei Wang, Dongdong Tong, Christopher Hoover, Fei Wu, Yingxun Liu, Lumin Wang, Liying Liu, Lei Ni, Tusheng Song, Chen Huang
Aberrant glycogene and glycan expression is intimately associated with carcinogenesis, invasion, and metastasis of gastric cancer (GC); however the regulatory mechanisms for glycogenes in GC cells remain unclear. Methyl-CpG-binding protein 2 (MeCP2) regulates genes by binding to methylated promoters, and in our previous work we found that it is overexpressed in GC cell lines and tissues, functioning as an oncogene. In this study we detected the expression of 212 glycogenes in MeCP2 silenced GC cells versus control using the Agilent Whole Human Genome Microarray and mining the data through bioinformatic analysis...
January 18, 2017: Glycobiology
https://www.readbyqxmd.com/read/28096310/characterization-of-the-dtdp-fuc3n-and-dtdp-qui3n-biosynthetic-pathways-in-campylobacter-jejuni-81116%C3%A2
#15
Zack Z Li, Alexander S Riegert, Marie-France Goneau, Anna M Cunningham, Evgeny Vinogradov, Jianjun Li, Ian C Schoenhofen, James B Thoden, Hazel M Holden, Michel Gilbert
The Gram-negative bacterium Campylobacter jejuni 81116 (Penner serotype HS:6) has a class E lipooligosaccharide (LOS) biosynthesis locus containing 19 genes, which encode for 11 putative glycosyltransferases, 1 lipid A acyltransferase and 7 enzymes thought to be involved in the biosynthesis of dideoxyhexosamine (ddHexN) moieties. Although the LOS outer core structure of C. jejuni 81116 is still unknown, recent mass spectrometry analyses suggest that it contains acetylated forms of two ddHexN residues. For this investigation, five of the genes encoding enzymes reportedly involved in the biosyntheses of these sugar residues were examined, rmlA, rmlB, wlaRA, wlaRB and wlaRG Specifically, these genes were cloned and expressed in Escherichia coli, and the corresponding enzymes were purified and tested for biochemical activity...
January 16, 2017: Glycobiology
https://www.readbyqxmd.com/read/28077463/novel-method-for-detection-of-glycogen-in-cells
#16
Alexander V Skurat, Dyann Segvich, Anna A DePaoli-Roach, Peter J Roach
Glycogen, a branched polymer of glucose, functions as an energy reserve in many living organisms. Abnormalities in glycogen metabolism, usually excessive accumulation, can be caused genetically, most often through mutation of the enzymes directly involved in synthesis and degradation of the polymer leading to a variety of glycogen storage diseases (GSDs). Microscopic visualization of glycogen deposits in cells and tissues is important for the study of normal glycogen metabolism as well as diagnosis of GSDs...
January 10, 2017: Glycobiology
https://www.readbyqxmd.com/read/28031251/expression-and-biochemical-characterization-and-substrate-specificity-of-the-fucoidanase-from-formosa-algae
#17
Artem S Silchenko, Nadezhda E Ustyuzhanina, Mikhail I Kusaykin, Vadim B Krylov, Alexander S Shashkov, Andrey S Dmitrenok, Roza V Usoltseva, Anastasiya O Zueva, Nikolay E Nifantiev, Tatyana N Zvyagintseva
A gene that encodes fucoidanase ffa2 in the marine bacterium Formosa algae strain KMM 3553(T) was cloned, and the protein (FFA2) was produced in Escherichia coli Recombinant fucoidanase FFA2 was purified, and the biochemical properties of this enzyme were studied. The amino acid sequence of FFA2 showed 57% identity with known fucoidanase FcnA from Mariniflexile fucanivorans. The mass of the gene product FFA2 is 101.2 kDa (918 amino acid residues). Sequence analysis has revealed that fucoidanase FFA2 belongs to the GH107 (CAZy) family...
December 28, 2016: Glycobiology
https://www.readbyqxmd.com/read/28025252/various-sulfated-carbohydrate-tumor-marker-candidates-identified-by-focused-glycomic-analyses
#18
Miki Tanaka-Okamoto, Mikio Mukai, Hidenori Takahashi, Yoshiyuki Fujiwara, Masayuki Ohue, Yasuhide Miyamoto
Glycomic analysis focused on sulfated O-glycans was performed to identify novel serum carbohydrate tumor markers. Sulfated glycans were enriched by α-neuraminidase digestion of pyridylaminated glycans prepared from sera, followed by anion exchange chromatography. Sulfated O-glycan profiles were constructed by two types of high performance liquid chromatography separation. Comparison of the profiles from 20 healthy controls with those of 11 gastric and 9 pancreatic cancer patients identified 14 marker candidates...
December 26, 2016: Glycobiology
https://www.readbyqxmd.com/read/28025251/non-reducing-end-labeling-of-heparan-sulfate-via-click-chemistry-and-a-high-throughput-elisa-assay-for-heparanase
#19
Zhengliang L Wu, Xinyi Huang, Cheryl Ethen, Timothy Tatge, Marta Pasek, Joseph Zaia
Heparan sulfate (HS) is a linear polysaccharide found in the extracellular matrix (ECM) and on the cell membrane. It plays numerous roles in cellular events, including cell growth, migration and differentiation through binding to various growth factors, cytokines and other ECM proteins. Heparanase (HPSE) is an endoglycosidase that cleaves HS in the ECM and cell membrane. By degrading HS, HPSE not only alters the integrity of the ECM but also releases growth factors and angiogenic factors bound to HS chains, therefore, changes various cellular activities, including cell mobility that is critical for cancer metastasis...
December 26, 2016: Glycobiology
https://www.readbyqxmd.com/read/28025250/glycosylation-of-muc1-influences-the-binding-of-a-therapeutic-antibody-by-altering-the-conformational-equilibrium-of-the-antigen
#20
Mohammadreza Movahedin, Teresa M Brooks, Nitin T Supekar, Naveen Gokanapudi, Geert-Jan Boons, Cory L Brooks
In cancer cells, the glycoprotein Mucin 1 (MUC1) undergoes abnormal, truncated glycosylation. The truncated glycosylation exposes cryptic peptide epitopes that can be recognized by antibodies. Since these immunogenic regions are cancer specific, they represent ideal targets for therapeutic antibodies. We investigated the role of tumor-specific glycosylation on antigen recognition by the therapeutic antibody AR20.5. We explored the affinity of AR20.5 to a synthetic cancer-specific MUC1 glycopeptide and peptide...
December 26, 2016: Glycobiology
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