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Bio-medical Materials and Engineering

Abbas Ghasemi, Babak Hashemi
The purpose of this study is to analyze the co-existence effect of 30 wt.% TCP-BG phases on degradation and precipitation behaviors of PLLA based composite scaffold in biological media. First, phase separation method was used to synthesize of the pure PLLA and the trinary composite scaffolds, and second they were immersed in SBF solution for 45 days. Subsequently, the degradation and precipitation characteristic were investigated by analyzing of pH value and weight changes of the immersed samples, the ability of biological products formation and the change of relative molecular weight of PLLA matrix as function of the degradation time...
2017: Bio-medical Materials and Engineering
Amit Aherwar, Marjan Bahraminasab
Biomaterials are continuously being developed to overcome the drawbacks of existing materials and provide improved function in artificial organs. Currently Co-Cr based alloys are used in many medical applications such as hip and knee implants which still require modification to better perform. In this article, therefore, the influence of tungsten allying element on electrochemical corrosion resistance and biocompatibility behaviour of a recently developed Co-30Cr-4Mo-1Ni alloy composition were investigated...
2017: Bio-medical Materials and Engineering
Yousef Amini, Saeid Amel Jamehdar, Keyvan Sadri, Sirwan Zare, Danial Musavi, Mohsen Tafaghodi
BACKGROUND: Effective encapsulation of drugs into the delivery systems could increase the efficiency of nanoparticles in prevention and treatment of diseases. OBJECTIVE: The purpose of this study was to compare the different methods for determination of encapsulation efficiency of a model protein in the PLGA nanoparticles. METHODS: The various direct methods include dichloromethane, acetonitrile, modified acetonitrile and NaOH based extraction and radioactive methods were used to directly calculate the encapsulation efficiency of the loaded protein in the PLGA nanoparticles...
2017: Bio-medical Materials and Engineering
Jingwan Luo, Longxiang Lin, Nina Liao, Keke Zhang, Chang Liu, Yulong Sun
The bursting strength is a key parameter to assess hemostatic ability of tissue sealants. It is associated to mechanical property of the materials, the binding strength of the materials to the tissues as well as the applied conditions of the materials, such as temperature and wound size. Few works have systematically investigated the relationship of the hemostatic ability of hydrogels with the factors listed above. This study introduced a method to systematically investigate the effect of the thickness, covered area and components of hydrogels, and the applied conditions on the bursting strength of hydrogels...
2017: Bio-medical Materials and Engineering
Didarul B Bhuiyan, John C Middleton, Rina Tannenbaum, Timothy M Wick
We have developed a novel multicomponent nano-hydroxyapatite-poly(D,L-lactide-co-glycolide)-collagen biomaterial (nHAP-PLGA-collagen) with mechanical properties similar to human cancellous bone. To demonstrate the bone forming capacity of nHAP-PLGA-collagen prior to in vivo experiments, nHAP-PLGA-collagen films and 3D porous scaffolds were seeded with human mesenchymal stem cells (hMSCs) to characterize cell proliferation and osteogenic differentiation. Over 21 days hMSCs seeded on 2D nHAP-PLGA-collagen films proliferate, form nodules, deposit mineral and express high alkaline phosphatase activity (ALP) indicating commitment of hMSCs towards osteogenic lineage...
2017: Bio-medical Materials and Engineering
M Kumar, S K Mishra
BACKGROUND: The clinical magnetic resonance imaging (MRI) images may get corrupted due to the presence of the mixture of different types of noises such as Rician, Gaussian, impulse, etc. Most of the available filtering algorithms are noise specific, linear, and non-adaptive. OBJECTIVE: There is a need to develop a nonlinear adaptive filter that adapts itself according to the requirement and effectively applied for suppression of mixed noise from different MRI images...
2017: Bio-medical Materials and Engineering
Julaiti Maitirouzi, Li Yanna, Adinaer Abulizi, Aizezi Aihemaitiniyazi, Shataer Kuerban, Huang Shaojun
OBJECTIVE: To investigate the effects of Uygur sand therapy on the mechanical properties of the femur bone of osteoarthritic rabbits. METHODS: Sixteen rabbits were injected with papain in the right posterior femoral articular cavity on the first, fourth and seventh day to establish the osteoarthritis (OA) rabbit model. Animals were divided into the experimental group and control group (8 rabbits each). The experimental group was treated with sand therapy, and the control group received no sand therapy treatment...
2017: Bio-medical Materials and Engineering
Fahimeh Sadat Tabatabaei, Ramin Samadi, Saeed Tatari
BACKGROUND: Reconstruction of bone defects is often performed using bone autografts. However, limitations associated with the use of autografts led to the use of bone substitute materials. OBJECTIVES: The purpose of this study was to compare the surface characteristics of three commercially available grafts namely allografts, xenografts and alloplasts. METHODS: This in vitro study was conducted on beta-tricalcium phosphate (β-TCP) alloplast, a mixture of demineralized bone matrix and mineralized bone allograft (DBM&MBA) and natural bovine bone mineral (NBBM) xenograft...
2017: Bio-medical Materials and Engineering
Vytautas Pockevicius, Mindaugas Cepenas, Donatas Miklusis, Vytautas Markevicius, Lina Zabuliene, Dangirutis Navikas, Algimantas Valinevicius, Darius Andriukaitis
This article explores a non-invasive method to determine interstitial fluid level and pressure in tissue. Interdigital electrodes were chosen by simulated results in software "Comsol multiphysis 4.3a". Environment model similar to human body was created. Measurements were carried out at different situations which can occur during preoperative and afterwards surgery. Non-invasive method decreases possibility of infection and will improve recovery process in postoperative period.
2017: Bio-medical Materials and Engineering
Fulufhelo Nemavhola
The effect of myocardial infarction on the global functioning of the heart is well known. Less is understood regarding the effect of LV fibrotic infarction on the cardiac mechanics of the septal wall. To determine this unknown, the stress and strain of septal wall on the healthy and infarcted rat heart model is measured by using finite element models of rat heart geometries. The main objective of this study was to utilized computational methods to study the effect of LV free wall fibrotic infarction on the healthy septal wall...
2017: Bio-medical Materials and Engineering
L Torrisi, C Scolaro
The physical properties of biocompatible titanium surfaces were modified using different techniques of surface treatment. Particularly the measurements of roughness and wetting ability were controlled using six different techniques: polishing, sandblasting, acid attack, laser ablation, ion implantation and nanoparticle deposition. The titanium surface wetting can be modified drastically depending on the used treatment to enhance the hydrophilic or the hydrophobic behaviour of the metallic biocompatible surface...
2017: Bio-medical Materials and Engineering
Kyoung-Tak Kang, Sung-Hwan Kim, Juhyun Son, Young Han Lee, Yong-Gon Koh
BACKGROUND: Computational models have been identified as efficient techniques in the clinical decision-making process. However, computational model was validated using published data in most previous studies, and the kinematic validation of such models still remains a challenge. Recently, studies using medical imaging have provided a more accurate visualization of knee joint kinematics. OBJECTIVE: The purpose of the present study was to perform kinematic validation for the subject-specific computational knee joint model by comparison with subject's medical imaging under identical laxity condition...
2017: Bio-medical Materials and Engineering
Remel Alingalan Salmingo, Tina Lercke Skytte, Marie Sand Traberg, Lars Pilgaard Mikkelsen, Kaj-Åge Henneberg, Christian Wong
Perthes' disease is a destructive hip joint disorder characterized by malformation of the femoral head in young children. While the morphological changes have been widely studied, the biomechanical effects of these changes still need to be further elucidated. The objective of this study was to develop a method to investigate the biomechanical alterations in Perthes' disease by finite element (FE) contact modeling using MRI. The MRI data of a unilateral Perthes' case was obtained to develop the three-dimensional FE model of the hip joint...
2017: Bio-medical Materials and Engineering
Clarisa Bozzini, Ginés Viscor, Juan C Ríos Kristjánsson, Emilio Picasso, Graciela Champin, Rosa M Alippi, Carlos E Bozzini
BACKGROUND: Physical activity plays a tremendous role in determining bone mechanical behavior, which is superimposed to gravidity. OBJECTIVE: Compare the geometric and material responses of the rat femur to a high intensity treadmill running training of a relatively short duration, as assessed by 3-point mechanical test. METHODS: Mature male rats (180.0 ± 30 g) were assigned (7 rats/group) to no exercise (NE) or treadmill exercise (EX)...
2017: Bio-medical Materials and Engineering
Andrea Němcová, Oto Janoušek, Martin Vítek, Ivo Provazník
The article deals with the testing of features for fatigue detection in electrooculography (EOG) records. An optimal methodology for EOG signal acquisition is described; the Biopac data acquisition system was used. EOG signals were being recorded while 10 volunteers were watching prepared scenes. Three scenes were created for this purpose - a rotating ball, a video of driving a car, and a cross. Recorded EOG signals were processed and 20 features were extracted. The features involved blinks, slow eye movement (SEM), rapid eye movement (REM), eye instability, magnitude, and periodicity...
2017: Bio-medical Materials and Engineering
S Uma Maheshwari, K Govindan, M Raja, A Raja, M B S Pravin, S Vasanth Kumar
Polyvinylalcohol (PVA) and Polyvinylpyrrolidone (PVP) blend incorporated with hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) is electrospun as nanofibrous composite scaffolds to act as suitable template for bone tissue engineering. Microscopic and spectroscopic characterizations confirm uniform integration of the crystalline calcium phosphate ceramics in the scaffolds. PVA-PVP blends are usually amorphous in nature and addition of phosphate ceramic particles specifically HAp elevates its crystalline behavior which is substantiated by XRD details...
2017: Bio-medical Materials and Engineering
Ningning Bai, Cui Tan, Qing Li, Zhongxian Xi
In this paper, a low-cost and multifunctional hydroxyapatite (HA)/pefloxacin (PFLX) drug eluting layer is coated on magnesium (Mg) alloy through a simple hydrothermal and dip process. The drug PFLX could provide effective prevention for bone infection and inflammation due to its broad-spectrum antibacterial property. And HA would promote the growth of new bone and further improve the biocompatibility of implants. Besides, both PFLX and HA exhibits excellent corrosion protection for Mg alloy substrate. This coating is of great value for improving the application of Mg alloy as biomaterials...
2017: Bio-medical Materials and Engineering
Ali Darroudi, Jaber Parchami, Morteza Kafaee Razavi, Ghazaleh Sarbisheie
OBJECTIVE: In this paper, an adaptive method based on error entropy criterion is presented in order to eliminate noise from Electroencephalogram (EEG) signals. METHOD: Conventionally, the Mean-Squared Error (MSE) criterion is the dominant criterion deployed in the adaptive filters for this purpose. By deploying MSE, only second-order moment of the error distribution is optimized, which is not adequate for the noisy EEG signal in which the contaminating noises are typically non-Gaussian...
2017: Bio-medical Materials and Engineering
Ke-Ju Ju, Ling-Ling Zhong, Xiao-Yu Ni, Lei Xia, Liu-Jun Xue, Guan-Liang Cheng
OBJECTIVE: This study aims to explore the application prospect of low oxygen dead space ventilation (LODSV) in evaluating vasomotor reactivity (VMR) by comparison between LODSV and breath-holding test (BHT). METHODS: Outpatient or inpatient patients who underwent transcranial Doppler sonography (TCD) were enrolled into this study. These patients successively underwent BHT and LODSV. The cooperation degree, tolerance conditions and adverse reactions in patients were recorded, and VMR was calculated, compared and analyzed...
2017: Bio-medical Materials and Engineering
Liqing Deng, Donghai Li, Zhouyuan Yang, Xiaowei Xie, Pengde Kang
Hydroxyapatite (HA) is a representative bone repairing biomaterial for its similar composition to human bones and teeth. However, pure HA is limited in application for some unwanted characteristic, such as it is brickle and weakness in degradation. In this study, we modified HA by doping magnesium (Mg) to the material and studied its property in vitro. Besides, we also evaluated the calvarial defect repair effect using MgHA combined with rhBMP-2 in goat model. According to our outcomes, HA composited Mg made the scaffold smooth and the pore regular...
2017: Bio-medical Materials and Engineering
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