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Bio-medical Materials and Engineering

Xiangdong Bi, Panita Maturavongsadit, Yu Tan, Morgan Watts, Evelyn Bi, Zachary Kegley, Steve Morton, Lin Lu, Qian Wang, Aiye Liang
BACKGROUND: Biocompatible hydrogel systems with tunable mechanical properties have been reported to influence the behavior and differentiation of mesenchymal stem cells (MSCs). OBJECTIVE: To develop a functionalized hydrogel system with well-defined chemical structures and tunable mechanical property for regulation of stem cell differentiation. METHODS: An in-situ forming hydrogel system is developed by crosslinking vinyl sulfone functionalized polyamidoamine (PAMAM) dendrimer and multi-armed thiolated polyethylene glycol (PEG) through a thiol-ene Michael addition in aqueous conditions...
December 12, 2018: Bio-medical Materials and Engineering
R J Limón-Martínez, I Olivas-Armendáriz, E Sosa-Rodarte, C I Rodríguez-Rodríguez, J F Hernández-Paz, L S Acosta-Torres, R García-Contreras, E Santos-Rodríguez, S A Martel-Estrada
BACKGROUND: The development of biomaterial scaffolds and implementation of tissue engineering techniques are necessary. Therefore, Polycaprolactone/Sodium Hyaluronate/Multiwalled Carbon Nanotubes/Extract of Mimosa tenuiflora composites have been produced by a thermally-induced phase separation method. OBJECTIVE: The objective of this research was to evaluate the in vitro bioactivity and in vitro biocompatibility of the composites. METHODS: The in vitro bioactivity of the composites was assessed by soaking them in simulated body fluid for 7, 14, 21, and 28 days...
December 12, 2018: Bio-medical Materials and Engineering
Jomjai Peerapattana, Yusuke Hattori, Makoto Otsuka
BACKGROUND: In order to manufacture pharmaceutical products, real-time monitoring in the manufacturing process is necessary, but large equipment cost is required to achieve it. OBJECTIVE: The aim of this research is to use ultra-violet-visible spectroscopy along with chemometrics procedure to simultaneously quantitative analysis of indomethacin (IMC) and benzoic acid (BA) in the gel during pharmaceutical manufacturing process. METHODS: The gel preparations were contained of 0...
December 12, 2018: Bio-medical Materials and Engineering
Chenghu Liu, Zhenhua Lin, Chunxia Qiao, Zenglin Zhao, Changbin Wang, Xiaoxia Sun, Yanping Shi
For medical devices directly or indirectly contacted with blood, hemocompatibility assay is of great importance during the biological evaluation. In ISO 10993-4:2017 - Biological evaluation of medical devices part 4, a selection of tests for interactions with blood is given with the rationale for selection of tests based on their intended use specified, however, the specific testing protocols may vary significantly when performing the hemocompatibility assays. In recent years, medical catheters have been widely used in clinical practice...
December 12, 2018: Bio-medical Materials and Engineering
Sergei G Kalinichenko, Natalya Yu Matveeva, Roman Ye Kostiv, Sergey S Edranov
BACKGROUND: Biodegradable implant coatings promote proliferation and expression of BMP-2, VEGF, and TGF-β2 genes and enhance BMP-2, VEGF, and TGF-β2 regulatory effects at different stages of reparative osteogenesis. OBJECTIVE: To study the topography and ratio of PCNA-, VEGF-, BMP-2-, and TGF-β2-immunoreactive cells in rat femoral bone after closed fracture and implantation of titanium implants with biodegradable calcium phosphate and hydroxyapatite coatings...
December 10, 2018: Bio-medical Materials and Engineering
Tatsunori Takahashi, Soichiro Itoh, Masakazu Kida
OBJECTIVE: We conducted ultrasonography (US) examination for asymptomatic elbow injuries in judo athletes to confirm availability of US screening for elbow. MATERIALS AND METHODS: One hundred and thirty-two black belts in judo (85 males and 47 females; mean age, 20.0 ± 1.6 years) participated in this screening. Forty-eight participants had a history of elbow injury (elbow-injury group), and 84 did not (no-elbow-injury group). All participants completed a survey in the form of a questionnaire...
December 10, 2018: Bio-medical Materials and Engineering
Yanchao Ma, Yanhong Li, Junlong Hao, Bin Ma, Tianning Di, Haitao Dong
BACKGROUND: Calcium polyphosphate (CPP) is a commonly used biomaterial in bone tissue engineering, but CPP is insufficient in osteoinduction. This study aimed to fabricate lithium doped CPP (LiCPP) scaffolds and assess their characterization, degradation, biocompatibility and osteogenesis behavior for bone tissue engineering. METHODS: The novel scaffold was characterized by XRD, FTIR and SEM. The porosity, cell mediated degradation behavior and mechanical properties were also investigated...
December 5, 2018: Bio-medical Materials and Engineering
Jiajia Qian, Weiye Cheng, Caiyun Zhang, Lufeng Hong, Weidong Chen, Guoxi Li
In order to enhance lipophilicity and oral bioavailability of paeoniflorin (PF), this study developed paeoniflorin-phospholipid complex (PF-PLC) by solvent-evaporation method. The optimum preparation technology of PF-PLC was screened by the combination of single factor and orthogonal experiment. The physicochemical properties of PF-PLC were evaluated via differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), X-ray power diffraction (XRD) and oil-water partition coefficient study (lgP)...
December 5, 2018: Bio-medical Materials and Engineering
Panagiotis Mallis, Efstathios Michalopoulos, Paschalis Pantsios, Foteini Kozaniti, Despoina Deligianni, Aggeliki Papapanagiotou, Catherine Stavropoulos Giokas
BACKGROUND: The primary therapeutic strategy in cardiovascular disease is the coronary artery bypass surgery, which involves the use of small diameter vascular grafts ( <6 mm). Human umbilical arteries could be used as a source for the development of these grafts. OBJECTIVE: The aim of this study was the decellularization of human umbilical arteries and the evaluation of their recellularization potential. METHODS: Decellularization of human umbilical arteries was performed with a detergent based protocol...
December 4, 2018: Bio-medical Materials and Engineering
Florian Ernst Martin Herrmann, Anja Lehner, Fabian Koenig, Trixi Hollweck, Cornelia Fano, Martin Dauner, Guenther Eissner, Christian Hagl, Bassil Akra
BACKGROUND/OBJECTIVE: Ischemic heart disease is a major cause of mortality worldwide. Myocardial tissue engineering aims to create transplantable units of myocardium for the treatment of myocardial necrosis caused by ischemic heart disease - bioreactors are used to condition these bioartificial tissues before application. METHODS: Our group developed a multimodal bioreactor consisting of a linear drive motor for pulsatile flow generation (500 ml/min) and an external pacemaker for electrical stimulation (10 mA, 3 V at 60 Hz) using LinMot-Talk Software to synchronize these modes of stimulation...
December 4, 2018: Bio-medical Materials and Engineering
Mustapha Zidi, Eric Allaire, Yohanes Tjandrawidjaja
BACKGROUND: Cellular treatments using mesenchymal stem cells (MSCs) cultured in 3D conditions constitute a solution to the classical surgery in treating abdominal aortic aneurysm (AAA). The recurrent question is: how this type of biotherapy changes the mechanical behavior of artery? METHODS: Experiments measurements based on xenograft rat model showed that the proposed cellular treatment leads to a decreasing radius and length of the AAA during its growth. An inverse finite element method was used to investigate the mechanical hyperelastic behavior of the AAA in the untreated case compared to the treated one...
October 29, 2018: Bio-medical Materials and Engineering
Gökay Karayeğen, I Cengiz Koçum, Dilek Çökeli Ler Serdaroğlu, Mustafa Doğan
BACKGROUND: Electrospinning is a highly effective method in order to generate nano-scaled fibers. In conventional electrospinning technique, geometry of nanofibers are mostly random due to the chaotic behavior of polymer jet. OBJECTIVE: Purpose of this study is to produce aligned nanofibers from PVP polymers with advanced electrospinning technique in order to be used in a potential novel sensor applications, tissue regeneration and engineering. METHODS: In this study, by using finite hollow cylinder focusing electrodes, an external electrostatic field is created...
2018: Bio-medical Materials and Engineering
Karina Nogueira Zambone Pinto, Carla Roberta Tim, Murilo Camuri Crovace, Bruno Rafael Orsini Rossi, Hueliton Wilian Kido, Nivaldo Antonio Parizotto, Edgar Dutra Zanotto, Oscar Peitl, Ana Claudia Rennó
This study aimed to investigate the in vivo tissue response of the Biosilicate® scaffolds in a model of tibial bone defect. Sixty male Wistar rats were distributed into bone defect control group (CG) and Biosilicate® scaffold group (BG).  Animals were euthanized 15, 30 and 45 days post-surgery. Stereomicroscopy, scanning electron microscopy, histopathological, immunohistochemistry and biomechanical analysis were used. Scaffolds had a total porosity of 44%, macroporosity of 15% with pore diameter of 230 μm...
2018: Bio-medical Materials and Engineering
Kyoung-Tak Kang, Juhyun Son, Sae Kwang Kwon, Oh-Ryong Kwon, Yong-Gon Koh
BACKGROUND: Medial unicompartmental knee arthroplasty (UKA) could be concerned with wear of the cartilage or the wear in the polyethylene (PE) insert. Mechanical alignment determines the biomechanical effect in the long term. However, previous computational studies all found that femoral and tibial components alignment in the UKA were rare, and the results varied. OBJECTIVE: The purpose of this study was to evaluate the biomechanical effect of the femoral and tibial component coronal alignment in varus and valgus conditions through computational simulation...
2018: Bio-medical Materials and Engineering
John Z Wu, Erik W Sinsel, Christopher M Warren, Daniel E Welcome
The rehabilitation squeeze ball is a popular device to help strengthen the hand, fingers and forearm muscles. The distributions of the contact pressure in the interface between the therapy ball and hand/fingers can affect the joint moment of each of the individual fingers, thereby affecting rehabilitation effects. In the current study, we evaluated the contact force distributions on the fingers when gripping a spherical object. Eight female adults [age 29 (9.1) years, mass 64.6 (7.1) kg, height 163.5 (1.9) cm, hand length 17...
2018: Bio-medical Materials and Engineering
Serkan Erdem, Mustafa Gür, Mete Onur Kaman
BACKGROUND: Various techniques have been developed in the treatment of fractures. One of these techniques is the internal fixation, which has an important place in practice. OBJECTIVE: In this study, fractured tibia bone has been treated with implants as numerically to investigate the stress behavior and the effect of plate material, shape and dimensions under pressure load. METHODS: The outer part of the bone is chosen as orthotropic and the inner part is chosen as isotropic material...
2018: Bio-medical Materials and Engineering
Noor Rahman, Waseem Ur Rahman, Rafiullah Khan
The crack propagation behavior near the initial crack were studied under the compact tension (CT) fracture toughness experiments test on bovine hip bone joint specimens. The bone specimens were prepared according to ASTM E-399 for plain fracture toughness tests. The specimens were cut from the hip joint both in the longitudinal and transverse direction to the collagen fiber orientation in the bone. The precrack or initial crack "a" were produced parallel and vertical to the lontudinal axis of bone in the longitudinal and transverse specimens respectively...
2018: Bio-medical Materials and Engineering
Eun-Bin Park, Jin-Chul Heo, Jong-Ha Lee
The incidence of heart disease increases with age. The typical method of monitoring arrhythmia is to use a body patch type sensor with a wet electrode. Even though this sensor is easy to use, it has several disadvantages such as problems caused by wet electrodes in tissues when they are monitored for long periods. Thus, a monitoring sensor integrated into clothes with a dry electrode is proposed. In this study, we developed a smart outdoor shirt equipped with a dry electrode electrocardiogram (ECG) sensor for a cardiac arrhythmia computer-aided diagnosis system...
2018: Bio-medical Materials and Engineering
Masayuki Ishihara, Satoko Kishimoto, Shingo Nakamura, Koichi Fukuda, Yoko Sato, Hidemi Hattori
Adipose tissue-derived stromal cells (ADSCs) contain lineage-committed progenitor cells that have the ability to differentiate into various cell types that may be useful for autologous cell transplantation to correct defects of skin, adipose, cartilage, bone, tendon, and blood vessels. The multipotent characteristics of ADSCs, as well as their abundance in the human body, make them an attractive potential resource for wound repair and applications to tissue engineering. ADSC transplantation has been used in combination with biomaterials, including cell sheets, hydrogel, and three-dimensional (3D) scaffolds based on chitosan, fibrin, atelocollagen, and decellularized porcine dermis, etc...
2018: Bio-medical Materials and Engineering
Prinza Lazar, Rajeesh Jayapathy, Jordina Torrents-Barrena, M Mary Linda, Beena Mol, J Mohanalin, Domenec Puig
Alzheimer is a degenerative disorder that attacks neurons, resulting in loss of memory, thinking, language skills, and behavioral changes. Computer-aided detection methods can uncover crucial information recorded by electroencephalograms. A systematic literature search presents the wavelet transform as a frequently used technique in Alzheimer's detection. However, it requires a defined basis function considered a significant problem. In this work, the concept of empirical mode decomposition is introduced as an alternative to process Alzheimer signals...
2018: Bio-medical Materials and Engineering
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