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Bio-medical Materials and Engineering

Achmad Syaifudin, Ryo Takeda, Katsuhiko Sasaki
The selection of stent and balloon type is decisive in the stenting process. In the treatment of an eccentric plaque obstruction, a symmetric expansion from stent dilatation generates nonuniform stress distribution, which may aggravate fibrous cap prone to rupture. This paper developed a new stent design to treat eccentric plaque using structural transient dynamic analysis in ANSYS. A non-symmetric structural geometry of stent is generated to obtain reasonable stress distribution safe for the arterial layer surrounding the stent...
2018: Bio-medical Materials and Engineering
Mohamad Javad Mirzaei-Parsa, Amin Ghanizadeh, Malihe T K Ebadi, Reza Faridi-Majidi
Fibrinogen plays a necessary role in blood clotting and wound healing. In this study, a new solvent mixture of formic acid/acetic acid with low toxicity was investigated as an alternative solvent for fibrinogen electrospinning. The nanofibers were analyzed by scanning electron microscope (SEM), simultaneous thermal analysis (STA) and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). The results showed that when the ratio of formic acid to acetic acid was 75/25 (v/v) the finest defect-free fibres with diameters ranging from 184 ± 37 to 241 ± 70 nm were obtained...
2018: Bio-medical Materials and Engineering
Chenghu Liu, Hongyu Luo, Min Wan, Li Hou, Xin Wang, Yanping Shi
During the last two decades, biodegradable/absorbable materials which have many benefits over conventional implants are being sought in clinical practices. However, to date, it still remains obscure for us to perform full physic-chemical characterization and biological risk assessment for these materials and related devices due to their complex design and coherent processing. In this review, based on the art of knowledge for biodegradable/absorbable materials and biological risk assessment, we demonstrated some promising strategies to establish and improve the current biological evaluation systems for these biodegradable/absorbable materials and related medical devices...
2018: Bio-medical Materials and Engineering
N Ameer Ahamad, Sarfaraz Kamangar, Irfan Anjum Badruddin
The current study investigates the curvature effect due to various angles of curvature on the blood flow in human artery. The stenosis is considered to have three sizes 70%, 80% and 90% blockage before the curve section of artery. Numerical study of four different angle of curvature was considered to understand the flow behavior of artery having various curvatures, on the hemodynamics factors that includes drop in arterial pressure, flow velocity as well as wall shear stress. It was found that, the augmentation of the flow resistance due to the curvature increases in presence of stenosis...
2018: Bio-medical Materials and Engineering
Dyna Jeanne Develos Godoy, Wijit Banlunara, Sukanya Jaroenporn, Polkit Sangvanich, Pasutha Thunyakitpisal
BACKGROUND: The data on biomaterial-mediated bone regeneration directly comparing commercially available scaffolds in aging and osteoporotic conditions remain sparse. OBJECTIVE: To investigate the effects of an absorbable collagen sponge (ACS) and a medical grade polycaprolactone-tricalcium phosphate (mPCL-TCP) scaffold on calvarial defect healing in ovary-intact and ovariectomized rats. METHODS: Forty-two, 5-month old female Sprague-Dawley rats were divided into sham (OVI) or ovariectomy (OVX) groups (n=21)...
2018: Bio-medical Materials and Engineering
Mahsa Jahed, Farzan Ghalichi, Mehdi Farhoudi
BACKGROUND: Circle of Willis (COW) is a network of cerebral artery which continually supplies the brain with blood. Any disturbance in this supply will result in trauma or even death. One of these damages is known as brain Aneurysm. Clinical methods for diagnosing aneurysm can only measure blood velocity; while, in order to understand the causes of these occurrences it is necessary to have information about the amount of pressure and wall shear stress, which is possible through computational models...
2018: Bio-medical Materials and Engineering
L Lotfi, J Javadpour, M R Naimi-Jamal
INTRODUCTION: The biological and mechanical properties of substances are relevant to their application as biomaterials and there are many efforts to enhance biocompatibility and mechanical properties of bio-medical materials. OBJECTIVES: In this study, to achieve a low rate of shrinkage during polymerization, good mechanical properties, and excellent biocompatibility, benzoxazine based composites were synthesized. METHODS: Benzoxazine monomer was synthesized using a solventless method...
2018: Bio-medical Materials and Engineering
Gessica Giusto, Giangiacomo Beretta, Cristina Vercelli, Emanuela Valle, Selina Iussich, Roberta Borghi, Patrizio Odetti, Fiammetta Monacelli, Clara Tramuta, Elena Grego, Patrizia Nebbia, Patrizia Robino, Rosangela Odore, Marco Gandini
BACKGROUND: Novel pectin-honey hydrogels have been developed and characterized as medical device. Ideally, a wound dressing should maintain optimal fluid affinity, permit moisture evaporation, protect the wound from microbes, and have shape-conformability, biocompatibility, and antibacterial activity. OBJECTIVE: A novel, simple and fast method to produce pectin-honey wound dressings is described. METHODS: The properties of these pectin-honey hydrogels were investigated, including swelling ability, water vapour transmission rate, hydrogen peroxide production, methylglyoxal content and antibacterial activity...
2018: Bio-medical Materials and Engineering
Qiannian Dong, Hui-Ling Yuan, Jia-Jia Qian, Cai-Yun Zhang, Wei-Dong Chen
Nanosuspensions technique is an important tool to enhance the saturation solubility and dissolution velocity of poorly soluble drugs. Trans-resveratrol (t-Res) with extensive pharmacological effects was severely restricted by poor solubility and short biological half-life. In this study, anti-solvent precipitation was employed to development trans-resveratrol nanosuspensions (t-Res NS) with PVPK30 as stabilizer. The physicochemical properties, in vitro release and in vivo pharmacokinetics of t-Res NS were investigated...
2018: Bio-medical Materials and Engineering
Jaejin Lee, Dohyeon Kim, Kyunghoon Yu, Youngki Cho, Joshua H You
BACKGROUND: Isometric cervical flexor system exercise (ICF) and isometric cervical extensor system exercise (ICE) are cervical stabilization techniques that have been used to restore cervical crossed syndrome (CCS)-associated forward head posture. However, the therapeutic effects and underlying motor control mechanisms remain elusive. PURPOSE: The purpose of present study was investigating the concurrent therapeutic effects of ICF and ICE on muscle size, muscle imbalance ratio, and muscle recruitment sequence using ultrasound imaging and electromyography...
2018: Bio-medical Materials and Engineering
Nuttawut Thuaksuban, Rungrot Pannak, Pleumjit Boonyaphiphat, Naruporn Monmaturapoj
BACKGROUND: Biocompatibility and degradation of poly ε-caprolactone (PCL)-Biphasic Calcium Phosphate (BCP) scaffolds fabricated by the "Melt Stretching and Compression Molding (MSCM)" technique were evaluated in rat models. OBJECTIVES: Degradation behaviors and histological biocompatibility of the PCL-20% BCP MSCM scaffolds and compare with those of PCL-20% β-tricalcium phosphate (TCP) scaffolds commercially fabricated by Fused Deposition Modeling (FDM) were evaluated...
2018: Bio-medical Materials and Engineering
Fu-Chen Kung
Imbalance crosslink density and polymer concentration gradient is formed within the traditional alginate hydrogel using calcium chloride as a crosslinking agent in external gelation for instantaneously process. In this studying, type I collagen (Col I) blended calcium salt form of poly(γ-glutamic acid) (γCaPGA) was mixing with RGD-modified alginate with convenient gelation process and suitable for practical use. The hydrophilicity of the resulting hydrogels was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests...
2018: Bio-medical Materials and Engineering
Jinfeng Yao, Haodong Chen, Qi Gao, Zhigang Liang
BACKGROUND: Alveolar cleft repair is an important step in the sequence of treatments for cleft lip and palate. Intrinsically osteoinductive materials have been the subject of research interest. OBJECTIVE: The aim of this study was to explore the use of osteoinductive biphasic calcium phosphate (BCP) ceramics to repair alveolar cleft defects in dogs. METHODS: We prepared two kinds of BCP ceramic with different physical characteristics: osteoinductive BCP (OBCP) and non-osteoinductive BCP (NBCP)...
2018: Bio-medical Materials and Engineering
Issei Takeuchi, Yukari Hida, Kimiko Makino
BACKGROUND: Nanoparticles with a diameter of 100-150 nm prepared using poly(lactide-co-glycolide) can be delivered to hair follicles. Moreover, it was shown that drug release from nanoparticles was prolonged by using poly(L-lactide-co-glycolide) (PLLGA). OBJECTIVE: The aim of this study was to prepared minoxidil-encapsulated PLLGA nanoparticles and accumulate minoxidil in hair follicles utilizing its drug delivery properties for effective treatment of male and female androgenetic alopecia...
2018: Bio-medical Materials and Engineering
Issei Takeuchi, Haruhiko Onaka, Kimiko Makino
BACKGROUND: Recently, polyethylene glycol (PEG) modified gold nanoparticles have been studied to maintaining long-term stability in biological fluids. Its biodistribution was also reported, however, comparison of bare gold nanoparticles and PEGylated gold nanoparticles with equal particle size is not sufficient. OBJECTIVE: We prepared bare gold nanoparticles and PEGylated gold nanoparticles with diameters of 20-30-nm or 50-nm to avoid the influence of particle diameter, and studied their biodistribution in the mouse...
2018: Bio-medical Materials and Engineering
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
Abbas Jafarizad, Ali Taghizadehgh-Alehjougi, Morteza Eskandani, Maryam Hatamzadeh, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Maryam Mohammadzadeh, Başak Toğar, Mehdi Jaymand
This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication...
2018: Bio-medical Materials and Engineering
Nuttawut Thuaksuban, Naruporn Monmaturapoj, Thunmaruk Luntheng
BACKGROUND: Polycaprolactone (PCL)-biphasic calcium phosphate (BCP) scaffolds fabricated using Melt-Stretching and Compression Molding (MSCM) can release calcium and phosphate ions, which are essential for bone formation. OBJECTIVE: Responses of the osteoblasts seeded on three groups of scaffolds including group A; PCL-20% BCP (%wt), group B; PCL-30% BCP and group C (control); pure PCL (100% PCL) were evaluated. METHODS: The cell-scaffold constructs were made by seeding osteoblast cell lines at 1×105 cells/scaffold...
2018: Bio-medical Materials and Engineering
Miglena Doneva, Dessislava Pashkouleva
OBJECTIVE: Understanding the biomechanical properties of hernia meshes is essential in facilitating their selection. The aim of this study was to evaluate the mechanical compatibility of hernia meshes and human abdominal fascia and assess their applicability in hernia repair. METHODS: Uniaxial tensile tests were performed. A total of eight hernia meshes were tested - three standard meshes (Surgimesh®, Surgipro™, TecnoMesh®) and five light-weight meshes (Optilene®, TiO2Mesh™, Parietex™, Vypro™ II, Ultrapro™)...
2018: Bio-medical Materials and Engineering
NiZaMiDingJiang ReXiaTi, ReXiDan AiKeReMu, KaHeErMan KaDeEr, Yan-Dong Fan, Zhao-Hai Feng, Kai Wang, TeWuErBaTi SuErTanNiYa, Tao-Tao Dou, Hai-Qiang Wu, MaiMaiTiLi AiSha, Xiao-Jiang Cheng
OBJECTIVE: To observe the short-term efficacy of Pipeline embolization divice (PED) for the treatment of complex intracranial aneurysms. METHODS: The clinical data of 29 consecutive patients with 32 intracranial aneurysms treated with PED between April 2015 to September 2016 were analyzed retrospectively. There were 3 small aneurysm, 15 large aneurysms, 8 giant aneurysms, 5 fusiform ayneurysms and 1 recidivation. The vessels include 25 anterior circulation and 4 posterior circulation...
2018: Bio-medical Materials and Engineering
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