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Bio-medical Materials and Engineering

Nuttawut Thuaksuban, Rungrot Pannak, Pleumjit Boonyaphiphat, Naruporn Monmaturapoj
BACKGROUND: Biocompatibility and degradation of poly ε-caprolactone (PCL)-Biphasic Calcium Phosphate (BCP) scaffolds fabricated by the "Melt Stretching and Compression Molding (MSCM)" technique were evaluated in rat models. OBJECTIVES: Degradation behaviors and histological biocompatibility of the PCL-20% BCP MSCM scaffolds and compare with those of PCL-20% β-tricalcium phosphate (TCP) scaffolds commercially fabricated by Fused Deposition Modeling (FDM) were evaluated...
2018: Bio-medical Materials and Engineering
Fu-Chen Kung
Imbalance crosslink density and polymer concentration gradient is formed within the traditional alginate hydrogel using calcium chloride as a crosslinking agent in external gelation for instantaneously process. In this studying, type I collagen (Col I) blended calcium salt form of poly(γ-glutamic acid) (γCaPGA) was mixing with RGD-modified alginate with convenient gelation process and suitable for practical use. The hydrophilicity of the resulting hydrogels was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests...
2018: Bio-medical Materials and Engineering
Jinfeng Yao, Haodong Chen, Qi Gao, Zhigang Liang
BACKGROUND: Alveolar cleft repair is an important step in the sequence of treatments for cleft lip and palate. Intrinsically osteoinductive materials have been the subject of research interest. OBJECTIVE: The aim of this study was to explore the use of osteoinductive biphasic calcium phosphate (BCP) ceramics to repair alveolar cleft defects in dogs. METHODS: We prepared two kinds of BCP ceramic with different physical characteristics: osteoinductive BCP (OBCP) and non-osteoinductive BCP (NBCP)...
2018: Bio-medical Materials and Engineering
Issei Takeuchi, Yukari Hida, Kimiko Makino
BACKGROUND: Nanoparticles with a diameter of 100-150 nm prepared using poly(lactide-co-glycolide) can be delivered to hair follicles. Moreover, it was shown that drug release from nanoparticles was prolonged by using poly(L-lactide-co-glycolide) (PLLGA). OBJECTIVE: The aim of this study was to prepared minoxidil-encapsulated PLLGA nanoparticles and accumulate minoxidil in hair follicles utilizing its drug delivery properties for effective treatment of male and female androgenetic alopecia...
2018: Bio-medical Materials and Engineering
Issei Takeuchi, Haruhiko Onaka, Kimiko Makino
BACKGROUND: Recently, polyethylene glycol (PEG) modified gold nanoparticles have been studied to maintaining long-term stability in biological fluids. Its biodistribution was also reported, however, comparison of bare gold nanoparticles and PEGylated gold nanoparticles with equal particle size is not sufficient. OBJECTIVE: We prepared bare gold nanoparticles and PEGylated gold nanoparticles with diameters of 20-30-nm or 50-nm to avoid the influence of particle diameter, and studied their biodistribution in the mouse...
2018: Bio-medical Materials and Engineering
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
Abbas Jafarizad, Ali Taghizadehgh-Alehjougi, Morteza Eskandani, Maryam Hatamzadeh, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Maryam Mohammadzadeh, Başak Toğar, Mehdi Jaymand
This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication...
2018: Bio-medical Materials and Engineering
Nuttawut Thuaksuban, Naruporn Monmaturapoj, Thunmaruk Luntheng
BACKGROUND: Polycaprolactone (PCL)-biphasic calcium phosphate (BCP) scaffolds fabricated using Melt-Stretching and Compression Molding (MSCM) can release calcium and phosphate ions, which are essential for bone formation. OBJECTIVE: Responses of the osteoblasts seeded on three groups of scaffolds including group A; PCL-20% BCP (%wt), group B; PCL-30% BCP and group C (control); pure PCL (100% PCL) were evaluated. METHODS: The cell-scaffold constructs were made by seeding osteoblast cell lines at 1×105 cells/scaffold...
2018: Bio-medical Materials and Engineering
Miglena Doneva, Dessislava Pashkouleva
OBJECTIVE: Understanding the biomechanical properties of hernia meshes is essential in facilitating their selection. The aim of this study was to evaluate the mechanical compatibility of hernia meshes and human abdominal fascia and assess their applicability in hernia repair. METHODS: Uniaxial tensile tests were performed. A total of eight hernia meshes were tested - three standard meshes (Surgimesh®, Surgipro™, TecnoMesh®) and five light-weight meshes (Optilene®, TiO2Mesh™, Parietex™, Vypro™ II, Ultrapro™)...
2018: Bio-medical Materials and Engineering
NiZaMiDingJiang ReXiaTi, ReXiDan AiKeReMu, KaHeErMan KaDeEr, Yan-Dong Fan, Zhao-Hai Feng, Kai Wang, TeWuErBaTi SuErTanNiYa, Tao-Tao Dou, Hai-Qiang Wu, MaiMaiTiLi AiSha, Xiao-Jiang Cheng
OBJECTIVE: To observe the short-term efficacy of Pipeline embolization divice (PED) for the treatment of complex intracranial aneurysms. METHODS: The clinical data of 29 consecutive patients with 32 intracranial aneurysms treated with PED between April 2015 to September 2016 were analyzed retrospectively. There were 3 small aneurysm, 15 large aneurysms, 8 giant aneurysms, 5 fusiform ayneurysms and 1 recidivation. The vessels include 25 anterior circulation and 4 posterior circulation...
2018: Bio-medical Materials and Engineering
Ilven Mutlu
In this study, highly porous Mg-Ca-Zn-Co alloy scaffolds for tissue engineering applications were prepared by powder metallurgy based space holder method. Mg-Ca-Zn-Co alloy foam can be used as a scaffold material for hard tissue generation. Mechanical properties of the porous specimens are close to cancellous bone. Increasing Zn content in the alloy decreased the Mg grain size and enhanced the mechanical properties. Increasing Zn content of the alloy from 1.0 to 8.0 wt.% increased the Young's modulus from 12 GPa to 23 GPa...
2018: Bio-medical Materials and Engineering
Toshiki Miyazaki, Takashi Sasaki, Yuki Shirosaki, Ken'ichi Yokoyama, Masakazu Kawashita
Although titanium (Ti) is clinically used for hard tissue reconstruction, it has low bone-bonding ability, i.e. bioactivity. Materials able to deposit apatite on their surfaces within the body is considered to exhibit bioactivity. Effects of the metallographic structure and machining process of Ti on its apatite-forming ability remains unclear. In this study, Ti substrates subjected to various preheating and machining processes were then subjected to NaOH and heat treatments. The apatite-forming abilities of resulting Ti were examined in simulated body fluid (SBF)...
2018: Bio-medical Materials and Engineering
Fatemeh Karami, Siamak Hossainpour, Farzan Ghalichi
Accumulation of cholesterol and other atherogenic lipids such as low-density lipoprotein (LDL) in artery wall causes reduction of vessel diameter and artery stenosis. The study of the mass transfer of these large molecules in the wall with considering effective factors on lumen flow and different physiological factors is the subject considered nowadays. In this paper, results of two dimensional and axi-symmetric simulations of three different models of the artery with 60% stenosis under pulsatile blood flow are presented...
2018: Bio-medical Materials and Engineering
Wenyu Fu, Qixiao Xia, Ruobing Yan, Aike Qiao
BACKGROUND: Braided stents, such as Pipeline Embolization Device (PED; ev3 Neurovascular, Irvine, CA, USA), are commonly used to treat cerebral aneurysms. However, little information is available on the compression and bending characteristics of such stents. OBJECTIVE: This paper investigates how geometrical parameters of braided stents influence their radial compression and bending characteristics. METHODS: Six groups of braided stent models with different braiding angles, numbers of wires and wire diameters are constructed...
2018: Bio-medical Materials and Engineering
Yumin Zhang, Jianru Wang, Yanmiao Ma, Bo Han, Xiaojun Niu, Jianchun Liu, Lan Gao, Jue Wang, Xiaoyan Zhai, Kaibo Chu, Liwang Yang
Based on a kind of sintered hydroxyapatite (HA) with a good cytocompatibility, a series of polylactic acid (PLA) and PLA/HA with the various PLA:HA weight ratio (5:5, 4:6, 3:7, 2:8, 1:9) were fabricated by supercritical CO2. The physical and chemical properties were evaluated by pH, degradation, water absorption, porosity, density, mechanical property, and cytotoxicity respectively. With the increase of HA content, the pH value and porosity increased gradually, while weight loss rate and the density showed a gradual downward trend...
2018: Bio-medical Materials and Engineering
Nidhi Garg, Hardeep S Ryait, Amod Kumar, Amandeep Bisht
BACKGROUND: WPS is a non-invasive method to investigate human health. During signal acquisition, noises are also recorded along with WPS. OBJECTIVE: Clean WPS with high peak signal to noise ratio is a prerequisite before use in disease diagnosis. Wavelet Transform is a commonly used method in the filtration process. Apart from its extensive use, the appropriate factors for wavelet denoising algorithm is not yet clear in WPS application. The presented work gives an effective approach to select various factors for wavelet denoise algorithm...
2018: Bio-medical Materials and Engineering
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Irene Cambieri, Mara Fumagalli, Stefania Casarin, Angelo Ferravante, Daniela Alotto, Maurizio Stella, Carlotta Castagnoli
BACKGROUND: The development of dermal scaffolds is of major interest in reconstructive surgery. Human Acellular Dermal Matrices (HADMs) provides biomechanical support and elicits new tissue formation. The use of allograft dermis is limited by its immunogenic characteristics. Our research group has focused on the use of human alloplastic glycerolized reticular dermis. OBJECTIVE: The dermal grafts were subjected to two different decellularization protocols in parallel, in order to compare the efficacy in the elimination of residual DNA...
2018: Bio-medical Materials and Engineering
Patricia Brassolatti, Hueliton Wilian Kido, Paulo Sérgio Bossini, Paulo R Gabbai-Armelin, Albaiza Nicoletti Otterço, Luciana Almeida-Lopes, Lisinéia Maria Zanardi, Marcos Aurélio Napolitano, Lucimar Retto da Silva de Avó, Lucimara Aparecida Forato, Fernando M Araújo-Moreira, Nivaldo Antonio Parizotto
INTRODUCTION: Burn injuries represent a high risk of morbidity and mortality. The wound healing process is complex and requires the participation of different types of cells. Therefore, new biomaterials, which innovate the wound healing process, are being investigated. OBJECTIVE: The aim of this study was to investigate the use of bacterial cellulose both in its pure state and enriched with lidocaine in full-thickness burns in rats. METHODS: Thirty rats (Wistar) (260 ± 20 gramas) divided into control group (CG), bacterial cellulose membrane group (MG) and bacterial cellulose membrane enriched with lidocaine group (MLG) were used...
2018: Bio-medical Materials and Engineering
Kazuhisa Fujita, Kosuke Nozaki, Naohiro Horiuchi, Kimihiro Yamashita, Hiroyuki Miura, Akiko Nagai
BACKGROUND: The periodontal ligament (PDL), which maintains homeostasis in the periodontium, is a group of specialized connective tissue fibers attached to both the cementum and alveolar bone. Regeneration of periodontium with PDL cells has been investigated, and the chemical and molecular structures of scaffolds control the adhesion and differentiation of cells. Therefore, the development of adequate materials for PDL-derived cells is essential to regenerate the periodontium. OBJECTIVE: We evaluated the suitable passage time for PDL-derived cells and investigated the behaviors of PDL-derived cells grown on hydroxyapatite (HAp) scaffolds coated with type I and type III collagen...
2018: Bio-medical Materials and Engineering
Yusuke Hattori, Yurie Seko, Jomjai Peerapattana, Kuniko Otsuka, Tomoaki Sakamoto, Makoto Otsuka
BACKGROUND: Since it can take an enormous amount of time and cost to discriminate counterfeit medicines by using conventional methods, counterfeit medicines has been spread in the world markets. OBJECTIVE: The purpose of this study was to develop a rapid and simple analytical method to discriminate counterfeit drugs using near infrared (NIR) spectroscopy. METHODS: Seven types of brand name tablet and generic tablets containing atorvastatin calcium sesquihydrate (AT) preparations were used as simulated counterfeit medicines...
2018: Bio-medical Materials and Engineering
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