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Acta Cirúrgica Brasileira

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https://www.readbyqxmd.com/read/29768541/vascular-endothelial-growth-factor-association-with-angiopoietin-1-promotes-improvement-in-ventricular-function-after-ischemic-cardiomyopathy-induced-in-mini-pigs
#1
André Lacerda de Abreu Oliveira, Jussara Peters Scheffer, Melissa Markoski, Andreia Koche, Alexsandra Balbinot, Fernanda Antunes, Renato Kalil
PURPOSE: To investigate the safety and clinical, hemodynamic and tissue improvement ability in mini pigs undergoing cell and gene therapy for the treatment of acute myocardial infarction. METHODS: Thirty-two mini pigs Br1 lineage, 12 months old, undergoing induction of acute myocardial infarction by occlusion of the diagonal branch of the paraconal coronary. They were divided into 4 groups: one control group and 3 treatment groups (cell therapy and gene cell therapy)...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768540/effect-of-melatonin-on-antioxidant-capacity-%C3%A4-nflammation-and-apoptotic-cell-death-in-lung-tissue-of-diabetic-rats
#2
Didem Onk, Oruç Alper Onk, Hüseyin Serkan Erol, Mustafa Özkaraca, Selim Çomaklı, Tülin Akarsu Ayazoğlu, Ufuk Kuyrukluyıldız, Süheyla Ünver
PURPOSE: To investigate the effects of melatonin on antioxidant capacity, inflammation and apoptotic cell death (through expression of cleaved-caspase 3) in lung tissue samples of diabetic rats. METHODS: Thirty male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control group) was made up of healthy rats. Group 2 (diabetes group) received streptozotocin at a dose of 50 mg/kg/day for 5 days.Group 3 (diabetes plus melatonin group) received streptozotocin at a dose of 50 mg/kg/day for 5 days and then they received melatonin at a dose of 20 mg/kg/day between 28thand 35thdays of the study...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768539/evaluation-of-prophylactic-and-therapeutic-effects-of-sildenafil-on-acute-radiation-proctitis-in-rats
#3
Erkan Yavuz, Gulcin Ercan, Onur Olgac Karagulle, Busra Yaprak Bayrak, Aytac Biricik, Candas Ercetin, Berk Gokcek, Hakan Yigitbas, Ramazan Kusaslan, Atilla Celik, Osman Bilgin Gulcicek
PURPOSE: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). METHODS: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. RESULTS: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768538/demineralized-bone-matrix-and-calcium-phosphate-cement-in-bone-regeneration-in-rats
#4
Luiz Carlos Ferreira da Silva, Gabriela Granja Porto, Emanuel Sávio de Souza Andrade, José Rodrigues Laureano Filho
PURPOSE: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. METHODS: Thirty Wistar rats were divided into 3 groups of 10 animals each. Two defects of 5-mm were made in the parietal bones of each animal. Group I had calcium phosphate cement placed in the experimental defect, Group II had filled with demineralized bone matrix and Group III had with the combination of the matrix and cement in equal parts...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768537/the-protection-effect-and-mechanism-of-hyperbaric-oxygen-therapy-in-rat-brain-with-traumatic-injury
#5
Pengcheng Xing, Ke Ma, Lijuan Li, Donglian Wang, Guoyong Hu, Wei Long
PURPOSE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on traumatic brain injury (TBI) outcome. METHODS: The modified Marmarou's weight drop device was used to generate non-lethal moderate TBI rat model, and further developed in vitro astrocytes culturing system. Then, we analyzed the expression changes of interested genes and protein by quantitative PCR and western blot. RESULTS: Multiple HBO treatments significantly reduced the expression of apoptosis promoting genes, such as c-fos, c-jun, Bax and weakened the activation of Caspase-3 in model rats...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768536/comparison-of-platelet-rich-plasma-versus-fibrin-glue-on-colonic-anastomoses-in-rats
#6
Yusuf Kenan Daglioglu, Ozgul Duzgun, Inanc Samil Sarici, Kemal Turker Ulutas
PURPOSE: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. METHODS: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768535/action-of-a-deproteinized-xenogenic-biomaterial-in-the-process-of-bone-repair-in-rats-submitted-to-inhalation-of-cigarette-smoke
#7
Daniela Vieira Buchaim, Patrícia Cincotto Dos Santos Bueno, Jesus Carlos Andreo, Domingos Donizeti Roque, José Sidney Roque, Marcelo Garcia Zilio, Jefferson Augusto Salatin, Natália Kawano, Gabriela Furlanette, Rogério Leone Buchaim
PURPOSE: To investigate if the inorganic bovine bone matrix changes the bone formation in rats submitted to inhalation of cigarette smoke. METHODS: Twenty Wistar rats were divided into two groups: Cigarette Clot Group (CCG), which in the inhalation chamber received the smoke of 10 cigarettes, 3 times a day, 10 minutes, for 30 days and had the surgical cavity filled by clot; Cigarette Biomaterial Group (CBG), submitted to the same inhalation technique but with the cavity filled by biomaterial...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768534/impact-of-dexmedetomidine-on-hemodynamics-in-rabbits
#8
Jianjun Ren, Changfa Li, Shuxian Ma, Jiangli Wu, Yanjie Yang
PURPOSE: To evaluate the effects of single intravenous administration of Dexmedetomidine (DEX) on hemodynamics in rabbits. METHODS: A total of 32 New Zealand white rabbits were randomly divided into the control group (Group C), Group D1 (2.75 μg/kg), Group D2 (5.5 μg/kg), and Group D3 (8.25 μg/kg) to compare systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), central venous pressure (CVP), left ventricular systolic pressure (LVSP), left ventricular end-stage diastolic pressure (LVEDP), left ventricular developmental pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax at different time points...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768533/investigation-of-the-effect-of-gestational-diabetes-on-fetal-cardiac-tissue-in-streptozotocin-%C3%A4-nduced-in-rats
#9
Ugur Turhan, Ercan Yilmaz, Mehmet Gul, Rauf Melekoglu, Yusuf Turkoz, Fatma Ozyalin, Hakan Parlakpinar, Yavuz Simsek
PURPOSE: To investigate the cause of congenital anomalies resulted from gestational diabetes on fetal cardiac tissue in experimental animal study model. METHODS: Totally 12 female Wistar albino rats were divided into two groups, each consisting of 6 rats. Streptozotocin (60 mg/kg) was administered intraperitoneally to the study group by dissolving in citrate solution. The rats with a blood glucose level of 200 mg/dL and above were considered to be diabetic rats...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768532/effect-of-cilostazol-in-experimental-model-of-degloving-injuries-in-rat-limbs
#10
André Pazio, Vital Burko Santos, Guataçara Schenfelder Salles Junior
PURPOSE: To evaluate the effect of the cilostazol on the evolution of partially avulsed flaps, using experimental model of cutaneous degloving in rat limbs. METHODS: A controlled and randomized experimental study was carried out in which the blood flow and the percentage of flap necrosis were evaluated. We compared the study group, which received cilostazol, and the control group, which received enteral saline solution in the postoperative period. The blood flow in the flap was evaluated through Laser Doppler flowmetry, and a planimetry using the IMAGE J® software was employed for the calculation of the area of necrosis...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668782/ghrelin-and-gastrointestinal-wound-healing-a-new-perspective-for-colorectal-surgery
#11
Humberto Fenner Lyra Junior, Igor Kunze Rodrigues, Leonardo de Lucca Schiavon, Armando José D Acâmpora
No abstract text is available yet for this article.
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668781/the-effect-of-metyrosine-on-oxidative-gastric-damage-induced-by-ischemia-reperfusion-in-rats-biochemical-and-histopathological-evaluation
#12
Orhan Çimen, Ferda Keskin Çimen, Mine Gülapoğlu, Aslı Özbek Bilgin, Arif Burak Çekiç, Hüseyin Eken, Zeynep Süleyman, Yasin Bilgin, Durdu Altuner
PURPOSE: To investigate the effect of metyrosine against I/R induced gastric damage in rats. METHODS: Eighteen albino Wistar male rats were divided into groups; gastric I/R (GIR), 50 mg/kg metyrosine+gastric I/R (MGIR), and sham (SG) groups. 50 mg/kg metyrosine was given to the MGIR group, and distilled water was given to the GIR and SG groups by the oral gavage. After 30 minutes, 25 mg/kg thiopental sodium was injected intraperitoneally. Ischemia was achieved for 1 hour by clamping the celiac artery of the MGIR and GIR groups, then reperfusion was achieved for 3 hours...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668780/the-role-of-oxymatrine-in-regulating-tgf-%C3%AE-1-in-rats-with-hepatic-fibrosis
#13
Jing Wu, Lin Pan, Xueqin Jin, Weihua Li, Hongbing Li, Jianmao Chen, Wen Yang
PURPOSE: To investigate whether oxymatrine (OMT) prevents hepatic fibrosis in rats by regulating liver transforming growth factor β1 (TGF-β1) level. METHODS: Hepatic fibrosis was induced in rats by thioacetamide (TAA). Blood was collected at the end of week 12 to determine the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH). Changes in liver tissue were observed after hematoxylin-eosin (HE) staining. RESULTS: Fibrosis was confirmed by Masson's collagen staining...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668779/effects-of-propofol-pretreatment-on-lung-morphology-and-heme-oxygenase-1-expression-in-oleic-acid-induced-acute-lung-injury-in-rats
#14
Zelong Tan, Huaizhou Wang, Jing Sun, Mingsheng Li
PURPOSE: To investigate the effects of propofol pretreatment on lung morphology and heme oxygenase-1 expression in oleic acid -induced acute lung injury in rats. METHODS: A total of 32 male Sprague-Dawley rats (250-300g) were randomly divided into the following four groups (n=8/group): group C, group OA, group OA+PR, and group OA+IX to compare related parameter changes. RESULTS: PaO2, PCO2, and PaO2/FiO2 were significantly different among the four treatment groups (P<0...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668778/erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668777/combined-effects-of-melatonin-and-topical-hypothermia-on-renal-ischemia-reperfusion-injury-in-rats
#16
Pablo Cambeses Souza, Emanuel Burck Dos Santos, Guilherme Lang Motta, Silvia Regina Bona, Pedro Guilherme Schaefer, Daniela Campagnol, Tiago Bortolini, Carlos Otávio Corso
PURPOSE: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. METHODS: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668776/muscle-regeneration-through-therapy-with-estromal-stem-cells-in-injury-of-infraespinhosus-muscle-of-sheep
#17
Aline Grama Moreira Brandão, Angélica Consalter, Juliana da Silva Leite, Helia Zamprogno, Ana Maria Reis Ferreira
PURPOSE: To evaluate the effects of rotator cuff muscle regeneration in sheep and establish an experimental model for the use of autologous stem cells as a treatment option for tendon injuries. METHODS: Infrared muscle tenotomies and Penrose drain implantation were performed on 12 shoulders of six clinically healthy adult sheep. After 60 days, the tendons were submitted to tissue repair, drainage removal, and divided into two groups according to the use of autologous stromal stem cells for treatment...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668775/effect-of-varying-hypoxia-reoxygenation-times-on-autophagy-of-cardiomyocytes
#18
Zhao Hu, Hong-Yan Cai, Yun-Yan Luo, Jian-Ming Xiao, Lin Li, Tao Guo
PURPOSE: To investigate the impact of different hypoxia reoxygenation (HR) times on autophagy of rat cardiomyocytes (H9C2). METHODS: Rat cardiomyocytes were randomly divided into normal control group (group A), hypoxia group (group B), 2 h HR group (group C), 12 h HR group (group D), and 24 h HR group (group E). LC3 II/LC3 I was determined via western blotting, and cell viabilities of cardiomyocytes were measured using methyl thiazolyl tetrazolium (MTT) assay. RESULTS: Cell viabilities in HR model groups were significantly lower than those of group A (P<0...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668774/effect-of-ozone-oxidative-preconditioning-on-inflammation-and-oxidative-stress-injury-in-rat-model-of-renal-transplantation
#19
Zhishun Wang, Qi Han, Yong-Lian Guo, Xiu-Heng Liu, Tao Qiu
PURPOSE: To investigate the effect of ozone oxidative preconditioning (OzoneOP) on inflammation and oxidative stress injury in rat model of renal transplantation. METHODS: Thirty six male Sprague Dawley (SD) rats were randomly divided into three groups. Sham group: rats were treated with opening and closing abdomen. Kidney transplantation group (KT group): SD rat received the donor's left kidney derived from another SD rat. Ozone oxidative preconditioning and kidney transplantation (OOP+KT group): donor SD rats received OzoneOP treatments by transrectal insufflations before kidney transplantation...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29668773/prospective-ultrasonographic-study-of-blood-flow-and-testicular-volume-in-patients-submitted-to-surgical-repair-of-inguinal-hernia-without-using-prosthesis
#20
Cláudio de Saboya David, Alberto Goldenberg
PURPOSE: To evaluate the behavior of arterial circulation and testicular volume in patients submitted to conventional inguinal hernia repair without the use of a synthetic prosthesis to reinforce the posterior wall. METHODS: A prospective observational clinical trial was performed on 26 male patients with unilateral inguinal hernia types I and II by the Nyhus classification, who underwent surgical correction using the modified Bassini technique. Bilateral Doppler ultrasonography was performed preoperatively, at the third and at the sixth postoperative month...
March 2018: Acta Cirúrgica Brasileira
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