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Acta Cirúrgica Brasileira

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https://www.readbyqxmd.com/read/30208134/liver-ischemia-and-reperfusion-injury-pathophysiology-and-new-horizons-in-preconditioning-and-therapy
#1
Paula Carolina Grande Nakazato, João Paulo Victorino, Clarice Fleury Fina, Karina Dal Sasso Mendes, Maria Cecília Jordani Gomes, Paulo Roberto Barbosa Evora, Luiz Augusto Carneiro D'Albuquerque, Orlando Castro-E-Silva
It is well known that during hepatic operative procedures, it is often critical that the irrigation is interrupted to avoid possible bleeding, blood transfusions, variable intensities, and their short and long-term consequences. It was believed in the past that the flow interruption should not exceed 20 minutes, which limited the use of this maneuver. However, it has been postulated that ischemia could be maintained for more than 60 minutes in healthy livers. The present paper review includes: 1) A brief introduction to justify the rationale of the review design; 2) Aspects of the pathophysiology of the three stages of the liver ischemia-reperfusion injury; 3) The innate and acquired immunity; 4) Oxidative stress; 5) Apoptosis and autophagy, Some essential biomarkers (Tumor Necrosis Factor-α, nitric oxide, metalloproteinases); and, finally; 6) Preventive ("cheating") strategies, non-pharmacological and pharmacological options to treat the liver IR injury...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208133/simulated-training-of-a-laparoscopic-vesicourethral-anastomosis
#2
Eudes Fontenele Moraes Pinheiro, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Rômulo Augusto da Silveira
PURPOSE: To develop a model and curriculum for simulated training of an effective and well accepted laparoscopic vesicourethral anastomosis (VUA). METHODS: Experimental longitudinal study of quantitative character. The sample consisted of 12 general surgery residents and 6 urology residents (R3). The training consisted of making twelve VUAs on synthetic organs. The training was divided into four sessions and accompanied by an instructor who performed positive feedback...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208132/the-role-of-vitamin-c-in-the-gene-expression-of-oxidative-stress-markers-in-fibroblasts-from-burn-patients
#3
Jessica Bonucci, Alfredo Gragnani, Marcelo Moraes Trincado, Victor Vincentin, Silvana Aparecida Alves Correa, Lydia Masako Ferreira
PURPOSE: To assess the action of vitamin C on the expression of 84 oxidative stress related-genes in cultured skin fibroblasts from burn patients. METHODS: Skin samples were obtained from ten burn patients. Human primary fibroblasts were isolated and cultured to be distributed into 2 groups: TF (n = 10, fibroblasts treated with vitamin C) and UF (n = 10, untreated fibroblasts). Gene expression analysis using quantitative polymerase chain reaction array was performed for comparisons between groups...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208131/comparative-safety-assessments-of-the-biosimilar-apz001-and-erbitux-in-pre-clinical-animal-models
#4
Xiaofei Wang, Jianmin Guo, Xinyu Deng, Yuankeng Huang, Caiguo Ye, Huiqing Liang, Junhua Rao, Wei Yang
PURPOSE: To evaluate the toxicity of Erbitux as well as its biosimilar APZ001 antibody (APZ001) in pre-clinical animal models including mice, rabbits and cynomolgus monkeys. METHODS: We performed analysis of normal behavior activity, autonomic and non-autonomic nervous functions, nervous-muscle functions, nervous excitability and sensorimotor functions on CD-1 mice. Subsequently, we studied that effects of APZ001 and Erbitux on respiratory system, cardiovascular system and kidney in Cynomolgus monkey models and performed local tolerance experiments on New Zealand rabbits...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208130/prospective-clinical-assessment-of-tibial-tuberosity-advancement-for-the-treatment-of-cranial-cruciate-ligament-rupture-in-dogs
#5
Luciano Pereira de Barros, Laura Raquel Rios Ribeiro, Letícia Cordeiro de Pina Camondá Pereira, Fernando Lucas Maschio Ferreira, Maria Eduarda Bastos Andrade Moutinho da Conceição, Luis Gustavo Gosuen Gonçalves Dias
PURPOSE: To evaluate clinically dogs that underwent tibial tuberosity advancement (TTA) six months previously. METHODS: Dogs of various breeds, gender, weight, and age that had CCL rupture and underwent TTA for treatment were included in this study. Parapatellar arthrotomy was performed in all patients to assess the joint for a ruptured ligament and meniscal injury before the TTA. The appropriate cage for the TTA was chosen with planning surgery. The surgical procedure was performed according to the literature, using a modified Maquet technique...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208129/bacterial-cellulose-to-reinforce-urethrovesical-anastomosis-a-translational-study
#6
Guilherme Tavares da Silva Maia, Amanda Vasconcelos de Albuquerque, Euclides Dias Martins Filho, Filipe Tenório de Lira Neto, Veridiana Sales Barbosa de Souza, Anderson Arnaldo da Silva, Mariana Montenegro de Melo Lira, Salvador Vilar Correia Lima
PURPOSE: To evaluate the efficacy of the cellulosic exopolysaccharide membrane (CEM) as a urethral reinforcement for urethrovesical anastomosis. METHODS: Twenty eight rabbits were submitted to urethrovesical anastomosis with or without CEM reinforcement. The animals were divided into 4 groups: C7, CEM7, C14 and CEM14: (C= only anastomosis or CEM = anastomosis + CEM), evaluated after 7 weeks, and 14 weeks. The biointegration and biocompatibility of CEM were evaluated according to stenosis, fistula, urethral wall thickness, urethral epithelium, rate of inflammation and vascularization...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208128/correlations-of-inhaled-no-with-the-ctni-levels-and-the-plasma-clotting-factor-in-rabbits-with-acute-massive-pulmonary-embolism
#7
Zeming Zhang, Zibo Meng, Yancun Wang
PURPOSE: To investigate the correlation of inhaled nitric oxide (NO) on plasma levels of cardiac troponin I (cTnI) and von Willebrand factor (vWF), glycoprotein (GP) IIb/IIIa, granule membrane protein 140 (GMP-140) in rabbits with acute massive pulmonary embolism (PE). METHODS: Thirty apanese white rabbits were divided into 3 groups, thrombus were injected in model group (n = 10), NO were inhalated for 24 h after massive PE in NO group (n = 10), saline were injected in control group (n = 10)...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30208127/morphological-and-immunohistochemical-analysis-of-proteins-caspase-3-and-xiap-in-rats-subjected-to-cerebral-ischemia-and-chronic-alcoholism
#8
Vagner Sarraipo Schiavoni, Jairo Pinheiro da Silva, Fermino Sanches Lizarte Neto, Múcio Luiz Cirino de Assis, Maria de Fátima Galli Sorita Tazima, Camila Albuquerque Melo de Carvalho, Daniela Pretti da Cunha Tirapelli, Carlos Gilberto Carlotti, Benedicto Oscar Colli, Luis Fernando Tirapelli
PURPOSE: To evaluate histopathological and ultrastructural changes and expression of proteins related to apoptosis CASPASE 3 and XIAP after experimental induction of temporary focal cerebral ischemia (90 minutes) due to obstruction of the middle cerebral artery in alcoholism model. METHODS: Forty adult Wistar rats were used, subdivided into 5 experimental groups: control group (C); Sham group (S); Ischemic group (I); Alcoholic group (A); and Ischemic and Alcoholized group (I+A): animals submitted to the same treatment of group A and after four weeks were submitted to focal cerebral ischemia during 90 minutes, followed by reperfusion of 48 hours...
August 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110066/erratum
#9
(no author information available yet)
[This corrects the article doi: 10.1590/s0102-865020180060000007].
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110065/immunhistochemical-analysis-of-nuclear-factor-kappa-beta-expression-in-etiopathogenesis-of-ovarian-tumors1
#10
Ercan Yilmaz, Mehmet Gul, Rauf Melekoglu, Isil Koleli
PURPOSE: To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. METHODS: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = ∑ Pi (i+1), where ''Pi'' is the percentage of stained cells in each intensity category (0-100%) and ''i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3)...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110064/immunoexpression-of-vascular-endothelial-growth-factor-and-b-cell-lymphoma-2-in-the-uterine-tissue-of-rats-treated-with-melatonin-in-the-estrus-phase1
#11
Neval Yaman Görük, Engin Deveci
PURPOSE: To investigate the effect of melatonin on uterine tissue in the ovariectomized rat model. METHODS: Fourty Wistar albino rats were divided into four groups for histologic and immunohistochemical examination. The rats were first numbered randomly and then randomly divided into 4 equal groups: control (group 1), torsion (group 2), torsion+detorsion (group 3) and torsion+detorsion+melatonin (group 4) groups. In addition, four Wistar albino rats were used for western blot analysis in each group...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110063/nf-kb-mediated-cx3cl1-activation-in-the-dorsal-root-ganglion-contributes-to-the-maintenance-of-neuropathic-pain-induced-in-adult-male-sprague-dawley-rats1
#12
Chenglong Liu, Fei Zhang, Haihua Liu, Fang Wei
PURPOSE: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. METHODS: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested at relevant time points during an observation period of 28 days. Expression of CX3CL1 and NF-κBin the dorsal root ganglion (DRG) were performed by using Western blotting and RT-PCR...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110062/gastroprotective-and-antioxidant-effects-of-eremurus-spectabilis-bieb-methanol-extract-and-its-isolated-component-isoorientin-on-indomethacin-induced-gastric-ulcers-in-rats1
#13
Esen Sezen Karaoğlan, Abdulmecit Albayrak, Zerrin Kutlu, Yasin Bayır
PURPOSE: To investigate the gastroprotective effect of methanol extract of E. spectabilis and its major component isoorientin. METHODS: Effects of isoorientin and methanol extract of E. spectabilis were investigated in indomethacin-induced gastric damage model on rats. Famotidine was used as the standard antiulcer drug. Numerical density of ulcer areas and oxidative status were determined on stomach tissues of rats. RESULTS: All doses of isoorientin and methanol extract decreased MDA level and increased SOD activity and GSH levels in the stomach tissue of rats...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110061/is-the-early-or-delayed-remote-ischemic-preconditioning-the-more-effective-from-a-microcirculatory-and-histological-point-of-view-in-a-rat-model-of-partial-liver-ischemia-reperfusion-1
#14
COMPARATIVE STUDY
Zsuzsanna Magyar, Gabor Varga, Anita Mester, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Katalin Peto, Norbert Nemeth
PURPOSE: To compare early- and late-effect remote ischemic preconditioning (RIPC) by analysing the microcirculatory, hemodynamic and histological changes in partial liver ischemia-reperfusion of rats. METHODS: 60-minute partial liver ischemia followed by 120-minute reperfusion was performed without (Control group, n=7) or with preconditioning. In RIPC groups a tourniquet was applied around the left thigh using 3 cycles of 10-minute ischemia/10-minute reperfusion, one (RIPC-1, n=7) or twenty-four hours (RIPC-24, n=7) before I/R...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110060/cardioprotective-effect-of-preconditioning-is-more-efficient-than-postconditioning-in-rats-submitted-to-cardiac-ischemia-and-reperfusion1
#15
José Gustavo Padrão Tavares, Paolo Ruggero Errante, Tânia Carmem Peñaranda Govato, Ênio Rodrigues Vasques, Renato Ribeiro Nogueira Ferraz, Murched Omar Taha, Francisco Sandro Menezes-Rodrigues, Afonso Caricati-Neto
PURPOSE: To investigate the cardioprotective effects of ischemic preconditioning (preIC) and postconditioning (postIC) in animal model of cardiac ischemia/reperfusion. METHODS: Adult rats were submitted to protocol of cardiac ischemia/reperfusion (I/R) and randomized into three experimental groups: cardiac I/R (n=33), preCI + cardiac I/R (n=7) and postCI + cardiac I/R (n=8). After this I/R protocol, the incidence of ventricular arrhythmia (VA), atrioventricular block (AVB) and lethality (LET) was evaluated using the electrocardiogram (ECG) analysis...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110059/the-effects-of-inhaled-no-on-plasma-vasoactive-factor-and-ctni-level-in-rabbits-with-acute-massive-pulmonary-embolism1
#16
Zeming Zhang, Zheng Li, Lu Chen, Yancun Wang
PURPOSE: To investigate changes in the plasma concentrations of cardiac troponin I (CTnI), thromboxane A2 (TXA2), prostaglandin I2 (PGI2) and endothelin-1 (ET-1) in rabbits with massive pulmonary embolism (AMPE) and the impact of nitric oxide inhalation (NOI) on these indices. METHODS: A total of 30 Japanese rabbits were used to construct an MPE model and were divided into 3 groups equally (n=10), including an EXP group (undergoing modeling alone), an NOI group (receiving NOI 2 h post-modeling) and a CON group (receiving intravenous physiological saline)...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110058/rectal-application-of-argan-oil-improves-healing-of-colorectal-anastomosis-in-rats1
#17
Aziz Mutlu Barlas, Serdar Kuru, Kemal Kismet, Turgut Cavusoglu, Yusuf Murat Bag, Mehmet Senes, Neslihan Cihan, Pinar Celepli, Yilmaz Unal, Sema Hucumenoglu
PURPOSE: To investigate the possible effects of argan oil on the healing of colorectal anastomoses. METHODS: n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. To the control and sham groups, 2 mL of 0.9% NaCl was administred rectally, and in the argan oil group, 2 mL/day argan oil was applied rectally for 7 days. RESULTS: The mean bursting pressures of the argan oil and sham groups were significantly higher than the values in the control group...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30110057/effects-of-baicalin-on-inflammatory-reaction-oxidative-stress-and-pkdl-and-nf-kb-protein-expressions-in-rats-with-severe-acute-pancreatitis1
#18
Yunzhong Qian, Yi Chen, Linyang Wang, Jinfa Tou
PURPOSE: To investigate the effects of baicalin on inflammatory reaction, oxidative stress and protein kinase D1 (PKD1) and nuclear factor-kappa B (NF-κB) protein expressions in severe acute pancreatitis (SAP) rats. METHODS: Sixty rats were divided into sham operation, model, and low-, medium- and high-dose baicalin group. SAP model was established in later 4 groups. The later 3 groups were injected with 0.1, 0.2 and 0.4 ml/100 g 5% baicalin injection, respectively...
July 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30020317/development-of-a-model-for-laparoscopic-cholecystectomy-video-assisted-training-a-randomized-study
#19
Francesco Mongelli, Davide La Regina, Michele Marengo, Ramon Pini, Andrea Saporito, Maurice FitzGerald, Matteo Di Giuseppe
PURPOSE: To identify the surgical trainee benefits through the use of video assisted training (VAT). METHODS: Twelve cases of uncomplicated laparoscopic cholecystectomy (LC) were selected. Edited video segments focused on essential intra-operative anatomical structure identification and critical surgical steps. Evaluation of these videos was constructed on a scoring system based on pre and post-teach tests. RESULTS: The mean value of the pre-teach score was 33...
June 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/30020316/impact-of-1-25-oh-2-d-3-on-tg-content-in-liver-of-rats-with-type-2-diabetes
#20
Yan Yang, Beibei Liu, Ling Gao, Qi Li, He Wang, Liandi Wang
PURPOSE: To evaluate the effects of 1,25 dihydroxy vitamin D3 (1,25(OH)2D3) on the content of triglyceride (TG), as well as on the gene and protein expressions of adiponectin receptor 2 (AdipoR2), p38 mitogen-activated protein kinase (P38MAPK), and lipoprotein lipase (LPL) in the liver of rats with type 2 diabetes mellitus (T2DM) so as to provide theoretical basis for exploring the mechanism by which 1,25(OH)2D3 regulates TG. METHODS: Wistar rats were divided into four groups (n=25), with different treatments and detected the gene and protein expressions of AdipoR2, p38MAPK, and LPL in the liver tissue by reverse transcription polymerase chain reaction (RT-PCR) and Western blotting...
June 2018: Acta Cirúrgica Brasileira
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