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Acta Cirúrgica Brasileira

Eric Lucas Dos Santos Cabral, Wilkson Ricardo Silva Castro, Davidson Rogério de Medeiros Florentino, Danylo de Araújo Viana, João Florêncio da Costa Junior, Ricardo Pires de Souza, Amália Cinthia Meneses Rêgo, Irami Araújo-Filho, Aldo Cunha Medeiros
The growth of the urban population raises concern about municipal public managers in the sense of providing emergency medical services (EMS) that are aligned with the needs of prehospital emergency medical care demanded by the population. The literature review aims at presenting the response time of emergency medical services in several parts of the world and discussing some factors that interfere in the result of this indicator such as GDP (Gross Domestic Product) percentage spent on health and life expectancy of countries...
December 2018: Acta Cirúrgica Brasileira
Leonardo de Souza Vasconcellos, Andy Petroianu, Juliana Ribeiro Romeiro, Wilson Campos Tavares Junior, Vivian Resende
PURPOSE: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly. METHODS: ixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. All patients underwent abdominal ultrasound to measure the spleen...
December 2018: Acta Cirúrgica Brasileira
Celina Teresa Castelo Branco Couto de Miranda, Djalma José Fagundes, Edinaldo de Miranda, Ricardo Santos Simões, Murched Omar Taha
PURPOSE: To investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning (IPC). METHODS: Thirty rats (EPM-Wistar), distributed in five groups of six animals each, were underwent anesthesia and laparotomy. The ischemia time was standardized in 60 minutes and the reperfusion time 120 minutes. IPC was standardized in 5 minutes of ischemia followed by 10 minutes of reperfusion accomplished before I/R...
December 2018: Acta Cirúrgica Brasileira
Rosa Helena de Figueiredo Chaves, Celice Cordeiro de Souza, Ismari Perini Furlaneto, Renan Kleber Costa Teixeira, Carolina Pinheiro de Oliveira, Emanuelle de Matos Rodrigues, Daniel Arthur Santos Dos Santos, Renata Cunha Silva, Nelson Elias Abrahão da Penha, Ana Rita de Lima
PURPOSE: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats. METHODS: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn't receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods...
December 2018: Acta Cirúrgica Brasileira
Marcelo Campos Moraes Amato, Bruno César Aprile, Cézar Augusto de Oliveira, Vinicius Marques Carneiro, Ricardo Santos de Oliveira
PURPOSE: To validate the porcine spine as a model for learning and practicing transforaminal percutaneous endoscopic lumbar procedures (TF-PELP). METHODS: TF-PELP was performed in three porcine cadaver lumbar spine levels. Anatomical features of the current cadaver were compared to human and porcine spines. Performance and documentation of endoscopic procedures were described. RESULTS: This study shows that this representative animal model reflects anatomical characteristics of the human spine...
December 2018: Acta Cirúrgica Brasileira
Liping Zhang, Ying Zhang, Xiaofeng Yu, Huali Xu, Dayuan Sui, Xuezhong Zhao
PURPOSE: To investigate the effect of alprostadil on myocardial ischemia/reperfusion (I/R) in rats. METHODS: Rats were subjected to myocardial ischemia for 30 min followed by 24h reperfusion. Alprostadil (4 or 8 μg/kg) was intravenously administered at the time of reperfusion and myocardial infarct size, levels of troponin T, and the activity of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in the serum were measured. Antioxidative parameters, nitric oxide (NO) content and phosphorylated endothelial nitric oxide synthase 3 (p-eNOS) expression in the left ventricles were also measured...
December 2018: Acta Cirúrgica Brasileira
Murched Omar Taha, Thaís de Melo Alexandre E Silva, Keimy Saori Ota, Wander Junqueira Vilela, Ricardo Santos Simões, Alberto Starzewski Junior, Djalma José Fagundes
PURPOSE: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR). METHODS: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping of the superior mesenteric artery; IRG: IR plus saline group: IRG+At: IR plus Atenolol group. Rats from IRG and IRG+At were subjected to 60 min of intestinal ischemia and 120 min of reperfusion...
December 2018: Acta Cirúrgica Brasileira
Qiao-Hong Zhao, Xi-Shan Zhang, Kun Wu, Jie Zhang, Tian-Fang Xia, Jian Chen, Zhen-Shen Qin, Li-Qun Pang
PURPOSE: To establish a method for the preparation of zoledronate liposome and to observe its effect on inducing the apoptosis of rat liver Kupffer cells. METHODS: Zoledronate was encapsulated in liposomes, and then the entrapment rate was detected on a spectrophotometer. The prepared Zoledronate liposome (0.01 mg/mL) was injected into the tail vein of SD rats. Three days later, the number of Kupffer cells (CD68 positive) in rat liver tissue was detected by immunohistochemistry...
December 2018: Acta Cirúrgica Brasileira
Orlando Castro-E-Silva, Luiz Augusto Carneiro D'Albuquerque, Marina Rodrigues Garcia Silveira, Patricia Zorzi, Jordan Bistafa Liu, Daniel Tófoli Queiroz Campos, João Paulo Victorino, Maria Cecília Jordani, Karina Dal Sasso Mendes, Paulo Roberto Barbosa Évora
PURPOSE: To analyze the effect of methylene blue (MB) therapy during the liver ischemia-reperfusion injury (I/R) process. METHODS: Thirty-five male Wistar rats were used, (70%) submitted to partial ischemia (IR) or not (NIR) (30%) were obtained from the same animal. These animals were divided into six groups: 1) Sham (SH), 2) Sham with MB (SH-MB); 3) I/R, submitted to 60 minutes of partial ischemia and 15 minutes of reperfusion; 4) NI/R, without I/R obtained from the same animal of group I/R; 5) I/R-MB submitted to I/R and MB and 6) NI/R-MB, without I/R...
December 2018: Acta Cirúrgica Brasileira
Paulo Roberto Barbosa Évora, Agnes Afrodite Sumarelli Albuquerque, Tales Rubens de Nadai, Enio David Mente, Ajith Kumar Sankarankuty, Orlando Castro-E-Silva
Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patients under cardiopulmonary bypass (CPB) cardiac surgery. Also, the benefits, and risks, regarding long-term survival, have not yet been established. Therefore, cardiac surgery morbimortality may be superior in patients with cancer disease. Also, immunologic and inflammatory changes secondary to CPB can also increase tumor recurrence...
November 2018: Acta Cirúrgica Brasileira
Roberta Junqueira de Lima, Taylor Brandão Schnaider, Antônio Marcos Coldibelli Francisco, Daniela FrancescatoVeiga
PURPOSE: To compare two suture threads, poliglecaprone 25 and nylon, used as intradermal suture for skin closure in women undergoing their first cesarean section. METHODS: This is a randomized clinical trial. A total of 60 women undergoing their first cesarean section were enrolled and prospectively assessed. They were randomly allocated to group I (n=30), which received an intradermal suture with nylon 4.0 or to group II (n=30), which had an intradermal suture with poliglecaprone 25, 4...
November 2018: Acta Cirúrgica Brasileira
Betânia Souza Monteiro, Bianka Souza Dos Santos, Bruna Lopes de Almeida, Emy Hiura, Wagner Alexey Back Fiorio, Gisele Pereira Valdetaro, Dariele Vieira Gonçalves, Caroline Saraiva Silva, Tatiana Champion, Daniela Campagnol
PURPOSE: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell. METHODS: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal)...
November 2018: Acta Cirúrgica Brasileira
Chang Yung Chia, Andréia Dantas Medeiros, André de Menezes Silva Corraes, José Eduardo Ferreira Manso, César Silveira Claudio da Silva, Christina Maeda Takiya, Ricardo Luís Vanz
PURPOSE: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats. METHODS: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, transforming growth factor β3β (TGFβ3)], and tensile strength were assessed. RESULTS: Treated wounds were smaller, contracted earlier and had increased angiogenesis, fewer CD68+ and M2 macrophages on days 7 and 15, but higher on day 20...
November 2018: Acta Cirúrgica Brasileira
Dinani Matoso Filho Armstrong, Gautam Sikka, Anderson da Costa Armstrong, Karen Ruggeri Saad, William Rodrigues de Freitas, Dan Ezra Berkowitz, Djalma José Fagundes, Lakshmi Santhanam, Murched Omar Taha
PURPOSE: To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes. METHODS: Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure (MAP) was measured in awake mice using tail-cuff system. Thoracic aortas were excised for evaluation of endothelial dependent vasodilation (EDV) by wire myography, as well as histological analyses...
November 2018: Acta Cirúrgica Brasileira
Lanxiu Cao, Juan Lv, Xian Zhao, Jiang Wang, Li Ma
PURPOSE: To investigate the efficacy and mechanisms of root tuber of Polygonum ciliinerve (Nakai) ohwi (rPC) which has been used to treat bacterial infection in traditional Chinese medicine. METHODS: With the mouse model of Staphylococcus aureus (S. aureus) pneumonia, the phenotype of rPC treated mice, including body weight, mortality, lung slices and bacterial burden were evaluated. Furthermore, inflammatory factors in bronchoalveolar lavage (BAL) were determined by ELISA and the distribution of T cells in lung was assessed by immunofluorescence assay...
November 2018: Acta Cirúrgica Brasileira
Delano Gurgel Silveira, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Hermano Alexandre Lima Rocha, Gleydson Cesar de Oliveira Borges
PURPOSE: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE). METHODS: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. The sample consisted of 12 livers of adult pigs weighing between 30 and 45 kg. A circular-shaped HR, 5 cm diameter and deformable materials was developed with a polypropylene cloth, metallic guide wire, epidural needle plastic guide and nylon string...
November 2018: Acta Cirúrgica Brasileira
Maria Angélica Baron Magalhães, Andy Petroianu, Alfredo José Afonso Barbosa, Juliano Alves Figueiredo, Luiz Ronaldo Alberti, Jurandir Marcondes Ribas Filho
PURPOSE: To evaluate the hepatic changes associated with gastric ischemia. METHODS: Thirty male rabbits were studied, distributed in 3 groups (n=10). Group 1: ligature and section of the gastric vasculature and removal of the liver after three hours; Group 2: ligature and section of the gastric vasculature and removal of the liver after 6 hours; Group 3: ligature and section of the gastric vasculature and removal of the liver after 12 hours. Blood samples were collected immediately before surgery and after the determined time of ischemia in each group to evaluate the hepatic function...
November 2018: Acta Cirúrgica Brasileira
Tuncer Simsek, Mesut Erbas, Basak Buyuk, Cigdem Pala, Hasan Sahin, Betul Altinisik
PURPOSE: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study. METHODS: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. After 15 days, all rabbits in the two groups were given general anesthesia with rocuronium of 1 mg/kg...
November 2018: Acta Cirúrgica Brasileira
Ni Deng, Lili Xie, Yongwei Li, Haishu Lin, Renhui Luo
To investigate the effect of oxymatrine on periodontitis in rats and related mechanism. Methods: Ninety SD rats were divided into control, model, 10, 20 and 40 mg/kg oxymatrine and tinidazole groups. The periodontitis model was established in later 5 groups. The 10, 20 and 40 mg/kg oxymatrine groups were intragastrically administrated with 10, 20 and 40 mg/kg oxymatrine, respectively. The tinidazole group was intragastrically administrated with 100 mg/kg tinidazole. The treatment duration was 4 weeks. The tooth mobility, gingival and plaque indexes, serum inflammatory factor levels and gingival tissue matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) protein levels were detected...
November 2018: Acta Cirúrgica Brasileira
Chengdong Piao, Zhengwei Li, Jie Ding, Daliang Kong
PURPOSE: To investigate the impact of bone mesenchymal stem cells (BMSCs) intervention on the viscoelasticity of sciatic nerve in rats with chronic alcohol intoxication (CAI). METHODS: The CAI rat models were prepared, divided into model groups, and treated with either BMSCs or basic fibroblast growth factor (bFGF). Then the rats underwent electrophysiological test and the serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), and metallothionein (MT) were measured...
October 2018: Acta Cirúrgica Brasileira
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