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Acta Cirúrgica Brasileira

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https://www.readbyqxmd.com/read/28403350/improving-reproducibility-and-external-validity-the-role-of-standardization-and-data-reporting-of-laboratory-rat-husbandry-and-housing
#1
José Luiz Fontoura-Andrade, Rivadávio Fernandes Batista de Amorim, João Batista de Sousa
Purpose: To identify the most relevant flaws in standardization in husbandry practices and lack of transparency to report them. This review proposes some measures in order to improve transparency, reproducibility and eventually external validity in experimental surgery experiments with rat model. Methods: We performed a search of scientific articles in PUBMED data base. The survey was conducted from august 2016 to January 2017. The keywords used were "reproducibility", "external validity", "rat model", "rat husbandry", "rat housing", and the time frame was up to January 2017...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403349/analysis-of-gene-expression-egfr-and-kras-microrna-21-and-microrna-203-in-patients-with-colon-and-rectal-cancer-and-correlation-with-clinical-outcome-and-prognostic-factors
#2
Thais Inácio de Carvalho, Paulo Cezar Novais, Fermino Sanches Lizarte, Renata Danielle Sicchieri, Marcella Suelma Torrecillas Rosa, Camila Albuquerque Mello de Carvalho, Daniela Pretti da Cunha Tirapelli, Fernanda Maris Peria, José Joaquim Ribeiro da Rocha, Omar Féres
Purpose: To evaluate the expression of EGFR, KRAS genes, microRNAs-21 and 203 in colon and rectal cancer samples, correlated with their age at diagnosis, histological subtype, value of pretreatment CEA, TNM staging and clinical outcome. Methods: Expression of genes and microRNAs by real time PCR in tumor and non-tumor samples obtained from surgical treatment of 50 patients. Results: An increased expression of microRNAs-21 and 203 in tumor samples in relation to non-tumor samples was found...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403348/neonatal-necrotizing-enterocolitis-rat-model-attenuated-by-a-remote-ischemic-preconditioning-in-the-pregnant
#3
Rúdnei de Oliveira Luciano Gomes, Ricardo Artigiani, José de Freitas Guimarães, Adriana Porto Nunes, Edna Frasson de Souza Montero, José Luiz Martins
Purpose: To evaluate the effect of remote ischemic preconditioning (r-IPC) administered to pregnant rats, in the ileum of newborn rats subjected to hypoxia and reoxygenation. Methods: We used three pregnant rats and their newborn rats distributed in three groups: 1) Control (C) - Newborn rats born from a pregnant rat which did not undergo any intervention; 2) Hypoxia-Reoxygenation (H/R) - Newborn rats born from a pregnant rat which did not undergo any intervention, and were subjected to hypoxia-reoxygenation; 3) Remote Ischemic Preconditioning (r-IPC) - newborn rats born from a pregnant rat which was subjected to remote ischemic preconditioning twenty-four hours before giving birth and the newborn rats were subjected to hypoxia-reoxygenation...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403347/influence-of-remote-ischemic-conditioning-and-tramadol-hydrochloride-on-oxidative-stress-in-kidney-ischemia-reperfusion-injury-in-rats
#4
Rita de Cássia Silva de Oliveira, Marcus Vinicius Henriques Brito, Rubens Fernando Gonçalves Ribeiro, Leonam Oliver Durval Oliveira, Andrew Moraes Monteiro, Fernando Mateus Viegas Brandão, Lainy Carollyne da Costa Cavalcante, Eduardo Henrique Herbster Gouveia, Higor Yuri Bezerra Henriques
Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403346/the-effects-of-ozone-on-bacterial-growth-and-thiol-disulphide-homeostasis-in-vascular-graft-infection-caused-by-mrsa-in-rats
#5
Barcin Ozturk, Tunay Kurtoglu, Selim Durmaz, Leyla Didem Kozaci, Filiz Abacigil, Bulent Ertugrul, Ozcan Erel
Purpose: To investigate the microbiological, inflammatory and oxidant effects of adjuvant ozone administration in experimental rat vascular graft infection model which has not been previously investigated. Methods: Forty adult Wistar rats were divided into Sham, Control, Vancomycin, Ozone, Vancomycin+Ozone groups. Grafts were inoculated with Methicillin-resistant Staphylococcus aureus (MRSA) strain and implanted subcutaneously. Rats were treated intraperitoneally with ozone and /or intramuscularly with vancomycin for 10 days...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403345/effects-of-hypertonic-saline-solution-associated-to-remote-ischemic-perconditioning-in-kidney-ischemia-reperfusion-injury-in-rats
#6
Marcus Vinicius Henriques Brito, Edson Yuzur Yasojima, Sandro Percário, Rubens Fernando Gonçalves Ribeiro, Lainy Carollyne da Costa Cavalcante, Andrew Moraes Monteiro, Rodrigo Paracampo Couteiro, Ivone Aline da Silva Rodrigues, Hellen Aparecida Geyer Dos Santos
Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403344/cyclosporine-a-attenuates-apoptosis-and-necrosis-after-ischemia-reperfusion-induced-renal-injury-in-transiently-hyperglycemic-rats
#7
Sylvio Valença de Lemos, Isabela Galvão Vianna, Yara Marcondes Machado Castiglia, Marjorie de Assis Golim, Aparecida Vitória Gonçalves de Souza, Lídia Raquel de Carvalho, Elenice Deffune, Paulo do Nascimento, Norma Sueli Pinheiro Módolo, Pedro Thadeu Galvão Vianna
Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5 mg.kg-1, five minutes before reperfusion. Comparison groups were isoflurane and propofol sham groups and isoflurane and propofol ischemia-reperfusion-induced renal injury...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403343/lycopene-and-resveratrol-pretreatment-did-not-interfere-with-the-liver-of-hepatectomized-rats
#8
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes
Purpose: To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats. Methods: The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403342/tissue-sulfomucin-and-sialomucin-content-in-colon-mucosa-without-intestinal-transit-subjected-to-intervention-with-curcuma-longa-curcumin
#9
Antonio José Tiburcio Alves, José Aires Pereira, Adrieli Heloísa Campardo Pansani, Daniela Oliveira Magro, Cláudio Saddy Rodrigues Coy, Carlos Augusto Real Martinez
Purpose: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods: Thirty-six rats were subjected to proximal right colostomy and distal mucous fistula. They were divided into two groups according to whether sacrifice was performed two or four weeks after the intervention. Each group was divided into three subgroups according to the enema applied daily: saline alone; curcumin at 50 mg/kg/day or curcumin at 200 mg/kg/day...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28403341/anatomo-radiological-correlation-using-18-fdg-pet-in-abdominal-sepsis-model-in-rats-a-preliminary-study
#10
Ítalo Medeiros Azevedo, Marília Daniela Ferreira Carvalho, Rafael Pereira Nascimento, Robson Macedo, Mônica Raquel de Souza Aquino, Aldo Cunha Medeiros
Purpose: To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model. Methods: Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used. Results: The mean standard uptake values (SUV) and lesion areas were 2...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300879/behavior-study-of-the-doped-castor-bean-polymer-rod-with-bioactive-glass-and-hidroxyapatite-in-mice-femur-medullary-canal
#11
Viviani Teixeira Dos Santos, Gilberto Gonçalves Facco, Hudman Cunha Ortiz, Iandara Schettert da Silva
Purpose To evaluate the polymer doped rods behavior with bioactive glass and hydroxyapatite for possible application as a fracture fixing method. Methods Twenty eight Rattus norvegicus Wistar underwent bone defect for access to the femoral medullary canal and distributed into three experimental groups: group A - doped castor bean polymer with bioactive glass; group B - castor bean polymer and; group C - castor bean polymer doped with bioactive glass and hydroxyapatite. After 15 and 60 evaluation days, the femurs were removed and sent for histology and scanning electron microscopy...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300878/surgical-model-pig-ex-vivo-for-venous-dissection-teaching-in-medical-schools
#12
Milton Ignacio Carvalho Tube, Fernando Antonio Campelo Spencer-Netto, Anderson Igor Pereira de Oliveira, Arthur Cesário de Holanda, Bruno Leão Dos Santos Barros, Caio Cezar Gomes Rezende, João Pedro Guerra Cavalcanti, Marília Apolinário Batista, Josemberg Marins Campos
PURPOSE: To investigate a method for development of surgical skills in medical students simulating venous dissection in surgical ex vivo pig model. METHODS: Prospective, analytical, experimental, controlled study with four stages: selection, theoretical teaching, training and assessment. Sample of 312 students was divided into two groups: Group A - 2nd semester students; Group B - students of 8th semester. The groups were divided into five groups of 12 students, trained two hours per week in the semester...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300877/mast-cell-concentration-and-skin-wound-contraction-in-rats-treated-with-ximenia-americana-l
#13
José de Castro Souza Junior Neto, Lígia Reis de Moura Estevão, Liriane Baratella-Evêncio, Marcela Gabriela Feitosa Vieira, Ricardo Santos Simões, Rinaldo Florencio-Silva, Luís Evêncio-Luz, Joaquim Evêncio-Neto
PURPOSE: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. METHODS: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia americana), GP (wounds that received vehicle), and GC (wounds without product application)...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300876/comparative-study-of-polypropylene-versus-parietex-composite%C3%A2-vicryl%C3%A2-and-ultrapro%C3%A2-meshes-regarding-the-formation-of-intraperitoneal-adhesions
#14
Maria de Lourdes Pessole Biondo-Simões, Laísa Brandão Carvalho, Lucas Tavares Conceição, Kassyane Bordignon Piccinelli Dos Santos, Wagner Augusto Schiel, Mayara Arantes, Tatiane da Silveira, Júlio César Magri, Fernanda Fabrini Gomes
PURPOSE: To compare the polypropylene mesh (Marlex®) to Vicryl®, Parietex composite® and Ultrapro® meshes to assess the occurrence of adhesions in the intraperitoneal implantation. METHODS: Sixty Wistar rats were allocated into three groups: PP+V, in which all the animals received a polypropylene and a Vicryl® mesh; PP+PC, with the implantation of polypropylene and Parietex composite® meshes and PP+UP, in which there was implantation of polypropylene and Ultrapro®...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300875/short-term-buserelin-administration-induces-apoptosis-and-morphological-changes-in-adult-rat-testes
#15
Behnaz Khadivi, Tahmineh Peirouvi, Masumeh Zirak JavanmardI, Yousef Rasmi
PURPOSE: To investigate the effect of buserelin on gonadal structure and function in adult male rats. METHODS: Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. RESULTS: The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300874/amniotic-membrane-as-an-option-for-treatment-of-acute-achilles-tendon-injury-in-rats
#16
Mariana de Castro Nicodemo, Lia Renó das Neves, Josafá Carvalho Aguiar, Flaviane de Souza Brito, Isabelle Ferreira, Luciana Barros Sant'Anna, Leandro José Raniero, Rodrigo Álvaro Lopes Martins, Paulo Roxo Barja, Emilia Angela Lo Schiavo Arisawa
PURPOSE: To evaluate the effect of human amniotic membrane (hAM) fragment on inflammatory response, proliferation of fibroblast and organization of collagen fibers in injured tendon. METHODS: Sixty rats were divided into 3 groups: C - surgical procedures without tendon lesion and with simulation of hAM application; I - surgical procedures, tendon injury and simulation of hAM application; T - surgical procedures, tendon injury and hAM application. These groups were subdivided into four experimental times (3, 7, 14 and 28 days)...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300873/the-renoprotective-effect-of-oral-tadalafil-pretreatment-on-ischemia-reperfusion-injury-in-rats
#17
Vanessa de Fátima Lima Paiva Medeiros, Ítalo Medeiros Azevedo, Marília Daniela Ferreira Carvalho, Cláudia Nunes Oliveira, Eryvaldo Sócrates Tabosa do Egito, Aldo Cunha Medeiros
To evaluate the effect of tadalafil in renal ischemia/reperfusion (I/R) injury in rats Methods: Group I/R saline rats (n=6) were subjected to 45 minutes of left renal ischemia and treated with saline; the I/R tadalafil rats (n=6) received oral 10mg/kg tadalafil microemulsion one hour before ischemia. In both groups, 8 hours after ischemia, laboratory analysis were performed Results: Better tissue perfusion was lower in ischemic left/kidney than in right/kidney in saline group, suggesting reduced kidney clearance...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300872/impacts-of-albumin-synergized-with-hydroxyethyl-starch-on-early-microvascular-albumin-leakage-after-major-abdominal-surgery-in-rabbits
#18
Weiming Li, Pengyuan Xu, Yunyun Cen, Dali Sun, Ting Yang, Qingwen Xu, Shumin Li, Yijun Li, Bo Ding
PURPOSE: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. METHODS: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28300871/glial-scar-modulation-as-therapeutic-tool-in-spinal-cord-injury-in-animal-models
#19
Jéssica Rodrigues Orlandin, Carlos Eduardo Ambrósio, Valéria Maria Lara
PURPOSE: Spinal Cord injury represents, in veterinary medicine, most of the neurological attendances and may result in permanent disability, death or euthanasia. Due to inflammation resulting from trauma, it originates the glial scar, which is a cell interaction complex system. Its function is to preserve the healthy circuits, however, it creates a physical and molecular barrier that prevents cell migration and restricts the neuroregeneration ability. METHODS: This review aims to present innovations in the scene of treatment of spinal cord injury, approaching cell therapy, administration of enzyme, anti-inflammatory, and other active principles capable of modulating the inflammatory response, resulting in glial scar reduction and subsequent functional improvement of animals...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28225921/model-for-simulated-training-of-laparoscopic-gastroenterostomy
#20
Márcio Alencar Barreira, Delano Gurgel Siveira, Hermano Alexandre Lima Rocha, Luiz Gonzaga de Moura, Charles Jean Gomes de Mesquita, Gleydson Cesar de Oliveira Borges
Purpose: To develop a model of gastroenterostomy and to analyze the acquisition of skills after training by simulation. Methods: Experimental longitudinal study and of a quantitative character. The sample consisted of twelve general surgery residents from four hospitals. The training consisted of making ten anastomoses divided equally into five sessions and it took place over a period of six weeks. The evaluation of the anastomoses considered the time and the analysis of the operative technique through the global evaluation scale Objective Structured Assessment of Technical Skills (OSATS)...
January 2017: Acta Cirúrgica Brasileira
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