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European Archives of Psychiatry and Clinical Neuroscience

Anna Wirz-Justice, Vladeta Ajdacic, Wulf Rössler, Hans-Christoph Steinhausen, Jules Angst
The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9.96%). A total of 7.52% suffered from autumn/winter seasonality in major and minor depressive mood states. The clinical interviews revealed novel findings: high comorbidity of Social Anxiety Disorder and Agoraphobia within the repeated seasonal MDE group, high incidence of classic diurnal variation of mood (with evening improvement), as well as a high rate of oversensitivity to light, noise, or smell...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
Isabelle Brunner, Michael Grözinger
The effect of electroconvulsive therapy (ECT) performed with ultrabrief pulse (UBP) stimulation has been found inferior to brief pulse (BP) ECT in various studies. We reinvestigated this issue using a new dosing strategy that is based on seizure quality instead of seizure threshold. There is a long history of studies associating ictal characteristics of ECT with the clinical outcome. Accordingly, we used the clinical status of the patient and the quality of the prior seizure to determine the dosage for the upcoming treatment-referred to as Clinical and Seizure Based Stimulation (CASBAS)...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
Golo Kronenberg, Markus Petermann, Christof Dormann, Michael Bader, Peter Gass, Rainer Hellweg, Friederike Klempin
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced...
July 17, 2018: European Archives of Psychiatry and Clinical Neuroscience
Sven Speerforck, F Dodoo-Schittko, S Brandstetter, C Apfelbacher, U Hapke, F Jacobi, H J Grabe, S E Baumeister, G Schomerus
BACKGROUND: Major depressive disorder (MDD) and bipolar disorder are associated with certain cardiovascular risk factors (CVRFs), but it is unclear whether they are associated with unfavourable changes of clinically manifest CVRFs over time. METHODS: We used baseline and 12-year follow-up (n = 1887) data from the German Health Interview and Examination Survey 1998. Multivariable linear regression models assessed associations between lifetime CIDI-diagnosed mood disorders at baseline and continuous risk factor-related outcomes (blood pressure, HbA1c, LDL-C, HDL-C, triglycerides, BMI) at follow-up...
July 16, 2018: European Archives of Psychiatry and Clinical Neuroscience
Kenji Hashimoto, Chun Yang
No abstract text is available yet for this article.
July 14, 2018: European Archives of Psychiatry and Clinical Neuroscience
Pegah Sarkheil, Martin Klasen, Frank Schneider, Rainer Goebel, Klaus Mathiak
Emotion regulation (ER) is crucial in terms of mental health and social functioning. Attention deployment (AD) and cognitive reappraisal (CR) are both efficient cognitive ER strategies, which are based on partially dissociated neural effects. Our understanding of the neural underpinnings of ER is based on laboratory paradigms that study changes of the brain activation related to isolated emotional stimuli. To track the neural response to ER in the changing and dynamic environment of daily life, we extended the common existing paradigms by applying a sequence of emotionally provocative stimuli involving three aversive images...
July 14, 2018: European Archives of Psychiatry and Clinical Neuroscience
Matthew R Williams, P Sharma, C Macdonald, R K B Pearce, S R Hirsch, M Maier
The corpus callosum has become a key area of interest for researchers in severe mental illness. Disruptions in fractional anisotropy in the callosum have been reported in schizophrenia and major depressive disorder. No change has been reported in oligodendrocyte density and overall size of the callosum in either illness, suggesting that gross morphology is unchanged, but subtler organisational disruption may exist within this structure. Using high-resolution oil immersion microscopy, we examined the cross-sectional area of the nerve fibre and the axonal myelin sheath; and using standard high-resolution light microscopy, we measured the density of myelinated axons...
July 6, 2018: European Archives of Psychiatry and Clinical Neuroscience
Karen M Ryan, Declan M McLoughlin
Both animal and human studies have implicated the neurotrophic and angiogenic mediator vascular endothelial growth factor (VEGF) in depression, with meta-analyses, indicating that protein levels are raised in patients with depression. In line with this, we have previously shown that VEGFA mRNA levels are higher in whole blood from patients with depression compared to controls, in particular in patients with psychotic unipolar depression, and that treatment with electroconvulsive therapy (ECT) alters VEGFA mRNA levels...
July 2, 2018: European Archives of Psychiatry and Clinical Neuroscience
V Buschert, D Prochazka, H Bartl, J Diemer, B Malchow, P Zwanzger, A Brunnauer
Physical activity is a common adjunctive therapy in psychiatric and psychosomatic hospitals. In the present study, we assessed the effects of an exercise program, integrated into routine inpatient treatment, on cognitive performance and subjective severity of depression in a sample of patients suffering from major depression. We randomized n = 38 patients with unipolar depression to either physical exercise (n = 18) or occupational therapy as an active control treatment (n = 20). Both treatments were delivered in group format over a period of 3-4 weeks...
June 27, 2018: European Archives of Psychiatry and Clinical Neuroscience
TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, XiaoChen Tang, YanYan Wei, Yan Wang, Qiang Hu, ZhenYing Qian, XiaoHua Liu, ChunBo Li, JiJun Wang
Our previous study has found that a long duration of untreated prodromal symptoms (DUPrS) does not increase the conversion risk to psychosis in individuals with attenuated psychosis syndrome (APS). However, whether a long DUPrS will lead to other poor outcomes remains unknown. The purpose of this study was to analyse the association between the DUPrS and outcomes (symptomatic and functional recovery) in APS population. A post hoc analysis was performed in 391 individuals with APS as identified by the structured interview...
June 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
Elisabeth M Weiss, Claudia Walter, Andreas Fink, Günter Schulter, Erich Mittenecker, Ilona Papousek
Following our previous cross-sectional analysis, indicating age-related improvements of response inhibition in a random-motor-generation task (MPT) in adolescents with Asperger syndrome (AS), the present study reports data from a 2.5-year follow-up examination in the original sample. We found more marked improvements within the follow-up interval in younger AS children, while older AS boys as well as typically developing (TD) boys remained at a relatively constant level throughout. The current longitudinal study further substantiates the notion that AS children (on average) catch up with TD children when they grow older as regards the basic inhibition of developing routine response patterns...
June 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ozge Kilic, Ekin Sonmez, Gamze Erzin, Sinan Guloksuz, Mariana Pinto da Costa
No abstract text is available yet for this article.
June 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
Wing Chung Chang, Jasmine Tsz Ting Liu, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Yi Nam Suen, Eric Yu Hai Chen
Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18-55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively...
June 22, 2018: European Archives of Psychiatry and Clinical Neuroscience
E Asselmann, K Beesdo-Baum, A Hamm, C O Schmidt, J Hertel, H J Grabe, C A Pané-Farré
Few epidemiological studies presented 12-month and lifetime prevalence estimates for DSM-IV mental disorders in the adult general population by sex and age up to very old age. From 2007 to 2010, DSM-IV mental disorders were assessed with the DIA-X/M-CIDI among N = 2400 participants (aged 29-89 years) from the Study of Health in Pomerania, an epidemiological study based on a two-stage stratified cluster sample randomly drawn from the adult general population in northeastern Germany. 36.3% of the sample was affected by any 12-month and 54...
June 15, 2018: European Archives of Psychiatry and Clinical Neuroscience
Giuseppe Delvecchio, Valentina Ciappolino, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
In the original publication of the article, the title was incorrect. The correct title should read as given below.
June 15, 2018: European Archives of Psychiatry and Clinical Neuroscience
Kenji Hashimoto
No abstract text is available yet for this article.
June 12, 2018: European Archives of Psychiatry and Clinical Neuroscience
Stéphane Raffard, Catherine Bortolon, Hanan Yazbek, Christophe Lançon, Michel Benoit, Joanna Norton, Delphine Capdevielle
Apathy is a frequent and debilitating condition with few treatment options available in schizophrenia patients. Despite evidence of its multidimensional structure, most of past studies have explored apathy through a categorical approach. The main objective of this study was to identify the cognitive, emotional, motivational, and clinical factors at baseline that best predicted the three subtypes of apathy dimensions at follow-up. In a longitudinal study, 137 participants diagnosed with schizophrenia underwent different assessments including clinical, motivational, affective and cognitive measurements, at 1-month (referred to as baseline) and 12-month follow-ups...
June 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
Xi Fang, Chun Yang, Shan Li, Gaofeng Zhan, Jie Zhang, Niannian Huang, Xiangxi Du, Hui Xu, Kenji Hashimoto, Ailin Luo
Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-receptor-kinase B (TrkB) contribute to individual differences in the development of neuropathic pain-induced anhedonia. Rats were randomly subjected to spared nerved ligation (SNI) or sham surgery...
June 7, 2018: European Archives of Psychiatry and Clinical Neuroscience
Laura Kranaster, Suna Su Aksay, Jan Malte Bumb, Carolin Hoyer, Christine Jennen-Steinmetz, Alexander Sartorius
Early identification of patients at high risk for an unfavorable outcome to ECT during the course might be beneficial because it provides an opportunity for timely intensification or optimization of stimulus conditions. We aimed to develop a new Seizure Quality Index (SQI) that delivers a clinical relevant outcome prediction early in the treatment course and can be used within common clinical setting. An observational study was conducted. Patients (n = 86) with a depressive episode and the clinical decision for ECT (right unilateral, brief pulse) were included, and several ictal parameters derived from the second ECT session and the clinical outcome of the patients were documented...
June 6, 2018: European Archives of Psychiatry and Clinical Neuroscience
Marije Swets, Frederike Schirmbeck, Jack Dekker, Lieuwe de Haan
Little is known about the co-prevalence of obsessive compulsive symptoms (OCS) and motor symptoms in patients with psychotic disorders. Cross-sectional associations between OCS and motor symptoms were assessed at baseline and at 3 years follow-up in patients (n = 726) with psychotic disorders and in their unaffected siblings (n = 761) from the Dutch Genetic Risk and Outcome of Psychosis (GROUP) study. Furthermore, longitudinal associations between changes in OCS and motor symptoms were evaluated. At baseline, OCS was not associated with any motor symptom (akathisia, dyskinesia, parkinsonism or dystonia) in patients...
May 29, 2018: European Archives of Psychiatry and Clinical Neuroscience
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