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European Archives of Psychiatry and Clinical Neuroscience

Moritz Bruno Petzold, Jennifer Lara Maria Mumm, Sophie Bischoff, Julia Große, Jens Plag, Ralf Brand, Andreas Ströhle
INTRODUCTION: While physical activity (PA) can play an important role in the treatment of mental disorders (MD), large proportions of patients with MD do not meet PA recommendations. The aim of this trial was to evaluate whether structured psychological intervention (MoVo-LISA) is effective in helping outpatients with MD to increase their level of PA. As active control group (CG) we modified MoVo-LISA to target healthy diet behavior. METHODS: N = 83 outpatients with MD (F1-F4) were randomized to the two conditions...
September 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ulf J Müller, Christian Mawrin, Thomas Frodl, Henrik Dobrowolny, Stefan Busse, Hans-Gert Bernstein, Bernhard Bogerts, Kurt Truebner, Johann Steiner
Deep brain stimulation (DBS) of the globus pallidus internus was recently proposed as a potential new treatment target for opioid addiction. DBS requires computer-assisted-3D planning to implant the stimulation electrode precisely. As volumes of brain regions may differ in addiction compared to healthy controls, our aim was to investigate possible volume differences in addicts compared to healthy controls. Volumes of the globus pallidus externus (PE) and internus (PI) in heroin addicts (n = 14) and healthy controls (n = 12) were assessed using morphometry of serial whole-brain sections...
September 1, 2018: European Archives of Psychiatry and Clinical Neuroscience
Èlia Vila, Elena Huerta-Ramos, Christian Núñez, Judith Usall, Belén Ramos
Accumulating evidence suggests that Specificity Protein 1 (SP1) and 4 (SP4) transcription factors are involved in the pathophysiology of schizophrenia. The therapeutic use of selective oestrogen modulators such as raloxifene added to antipsychotic drugs in the treatment of postmenopausal women with schizophrenia has been investigated in a few clinical trials, which reported an improvement in negative, positive, and general psychopathological symptoms. We aimed to investigate the possible association between peripheral SP protein levels and symptom improvement in postmenopausal women with schizophrenia treated with adjuvant raloxifene...
August 30, 2018: European Archives of Psychiatry and Clinical Neuroscience
Hubertus Himmerich, Matthew Hotopf, Hitesh Shetty, Ulrike Schmidt, Janet Treasure, Richard D Hayes, Robert Stewart, Chin-Kuo Chang
Anorexia nervosa (AN) is found associated with increased mortality. Frequent comorbidities of AN include substance use disorders (SUD), affective disorders (AD) and personality disorders (PD). We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders in the observation window between January 2007 and March 2016 for 1970 people with AN, using data from the case register of the South London and Maudsley (SLaM) NHS Foundation Trust, an almost monopoly-secondary mental healthcare service provider in southeast London...
August 17, 2018: European Archives of Psychiatry and Clinical Neuroscience
Robert M Post, Lori L Altshuler, Ralph Kupka, Susan L McElroy, Mark A Frye, Michael Rowe, Heinz Grunze, Trisha Suppes, Paul E Keck, Willem A Nolen
The effect of assortative mating on offspring is often not considered. Here, we present data on illness in the spouse and the parents of patients with bipolar disorder as they affect illness in the offspring. A history of psychiatric illness (depression, bipolar disorder, suicide attempt, alcohol abuse, drug abuse, and "other" illness) was elicited for the parents, spouse, and the offspring of 968 patients with bipolar disorder (540 of whom had children) who gave informed consent for participation in a treatment outcome network...
August 11, 2018: European Archives of Psychiatry and Clinical Neuroscience
Fadwa Cazala, Véronique Fonteille, Virginie Moulier, Mélanie Pélégrini-Issac, Christiane De Beaurepaire, Marlène Abondo, Magali Bodon-Bruzel, Jean Cano, Florent Cochez, Taoufik Fouli, Catherine Thevenon, Bernard Dauba, Michel Pugeat, Serge Stoléru
Structural and functional neuroimaging techniques have recently been used to investigate the mechanisms of sexual attraction to children, a hallmark of pedophilic disorder, and have reported many contradictory or non-replicated findings. Here, our purpose was to identify through functional magnetic resonance imaging the brain responses of 25 male outpatients with pedophilic disorder to visual stimuli depicting children (VSc) and to compare them with 24 male healthy controls matched on sexual orientation (to female or male adults), age, and handedness...
August 9, 2018: European Archives of Psychiatry and Clinical Neuroscience
Maike Creyaufmüller, Stefan Heim, Ute Habel, Juliane Mühlhaus
One of the most prominent symptoms of schizophrenia is thought disorder, which manifests itself in language production difficulties. In patients with thought disorders the associations are loosened and sentence production is impaired. The determining behavioral and neural mechanisms of sentence production are still an important subject of recent research and have not yet been fully understood. The aim of the current study was to examine the influence of associative relations and distractor modalities on sentence production in healthy participants and participants with schizophrenia...
August 9, 2018: European Archives of Psychiatry and Clinical Neuroscience
Steffen Moritz, Yvonne Nestoriuc, Winfried Rief, Jan Philipp Klein, Lena Jelinek, Judith Peth
Despite growing awareness of occasional adverse effects of psychological treatments, only a few instruments cover side effects and other unwanted effects of psychotherapy. For the present study, the Positive and Negative Effects of Psychotherapy Scale (PANEPS) was evaluated in a population of individuals with depression who had completed at least one course of face-to-face psychotherapy. A total of 135 individuals with a current or previous depressive episode as verified by a diagnostic interview filled out the online version of the PANEPS, which is designed to capture both positive and adverse events...
August 7, 2018: European Archives of Psychiatry and Clinical Neuroscience
Karin Gmitterová, Joanna Gawinecka, Franc Llorens, Daniela Varges, Peter Valkovič, Inga Zerr
Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) share a couple of clinical similarities that is often a source of diagnostic pitfalls. We evaluated the discriminatory potential of brain-derived CSF markers [tau, p-tau (181P), Aβ1-42 , NSE and S100B] across the spectrum of Lewy body disorders and assessed whether particular markers are associated with cognitive status in investigated patients. The tau CSF level, amyloid β1-42 and p-tau/tau ratio were helpful in the distinction between DLB and PDD (p = 0...
August 6, 2018: European Archives of Psychiatry and Clinical Neuroscience
Brian J Lithgow, Zahra Moussavi, Caroline Gurvich, Jayashri Kulkarni, Jerome J Maller, Paul B Fitzgerald
Bipolar disorder (BD) is a severe mood disorder that lacks established electrophysiological, neuroimaging or biological markers to assist with both diagnosis and monitoring disease severity. This study's aim is to describe the potential of new neurophysiological features assistive in BD diagnosis and severity measurement utilizing the recording of electrical activity from the outer ear canal called Electrovestibulography (EVestG). From EVestG data sensory vestibulo-acoustic features were extracted from a single supine-vertical translation stimulus to distinguish 50 depressed and partly remitted/remitted bipolar disorder patients [18 symptomatic (BD-S, MADRS > 19), 32 reduced symptomatic (BD-R, MADRS ≤ 19)] and 31 age and gender matched healthy individuals (controls)...
August 6, 2018: European Archives of Psychiatry and Clinical Neuroscience
G Fond, M Faugere, C Faget-Agius, M Cermolacce, R Richieri, L Boyer, C Lançon
Hypovitaminosis D has been associated with, respectively, major depressive disorder, schizophrenia (SZ), and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objective was to determine the prevalence of hypovitaminosis D and associated factors in a non-selected multicentric sample of SZ subjects in day hospital. Hypovitaminosis D was defined by blood vitamin D level < 25 nM. Depressive symptoms were assessed by the Calgary Depression Rating Scale Score and Positive and Negative Syndrome Scale Score...
August 4, 2018: European Archives of Psychiatry and Clinical Neuroscience
Corinne Neukel, Sabine C Herpertz, Catherine Hinid-Attar, Anna-Lena Zietlow, Anna Fuchs, Eva Moehler, Felix Bermpohl, Katja Bertsch
Early life maltreatment (ELM) has long-lasting effects on social interaction. When interacting with their own child, women with ELM often report difficulties in parenting and show reduced maternal sensitivity. Sensitive maternal behavior requires the recognition of the child's emotional state depicted in its facial emotions. Based on previous studies, it can be expected that ELM affects the neural processing of facial emotions by altering activation patterns in parts of the brain's empathy and mentalizing networks...
July 28, 2018: European Archives of Psychiatry and Clinical Neuroscience
Cornelia Ower, Georg Kemmler, Theresa Vill, Caroline Martini, Andrea Schmitt, Barbara Sperner-Unterweger, Katharina Hüfner
OBJECTIVE: Physical activity (PA) in an outdoor environment has been shown to exert positive effects on mental well-being beyond those found for PA indoors. The specific effect of an alpine environment has not been investigated so far. Here we evaluate the association of PA in an alpine environment with resilience and quality of life (QOL) in patients with psychosomatic disorders and controls. METHODS: 194 patients with psychosomatic disorders (mostly somatoform disorder and major depressive syndrome) and 326 healthy controls were included in this web-based cross-sectional study...
July 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
J Angst, K R Merikangas, L Cui, A Van Meter, V Ajdacic-Gross, W Rössler
Growing evidence for the spectrum concept of most mental disorders, particularly mood disorders, has challenged the arbitrary distinctions inherent in the contemporary categorical diagnostic classification system. Detection of manic symptoms in the context of episodes of depression is particularly important because of the implications for differential treatment of bipolar vs unipolar depression. The purpose of this study is to characterize the magnitude and clinical correlates of subthreshold manic syndromes or symptoms among people with major depressive disorder (MDD) compared to those without a history of manic symptoms...
July 21, 2018: European Archives of Psychiatry and Clinical Neuroscience
Anna Wirz-Justice, Vladeta Ajdacic, Wulf Rössler, Hans-Christoph Steinhausen, Jules Angst
The prevalence of autumn/winter seasonality in depression has been documented in the longitudinal Zurich cohort study by five comprehensive diagnostic interviews at intervals over more than 20 years (N = 499). Repeated winter major depressive episodes (MDE-unipolar + bipolar) showed a prevalence of 3.44% (5× more women than men), whereas MDE with a single winter episode was much higher (9.96%). A total of 7.52% suffered from autumn/winter seasonality in major and minor depressive mood states. The clinical interviews revealed novel findings: high comorbidity of Social Anxiety Disorder and Agoraphobia within the repeated seasonal MDE group, high incidence of classic diurnal variation of mood (with evening improvement), as well as a high rate of oversensitivity to light, noise, or smell...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
Isabelle Brunner, Michael Grözinger
The effect of electroconvulsive therapy (ECT) performed with ultrabrief pulse (UBP) stimulation has been found inferior to brief pulse (BP) ECT in various studies. We reinvestigated this issue using a new dosing strategy that is based on seizure quality instead of seizure threshold. There is a long history of studies associating ictal characteristics of ECT with the clinical outcome. Accordingly, we used the clinical status of the patient and the quality of the prior seizure to determine the dosage for the upcoming treatment-referred to as Clinical and Seizure Based Stimulation (CASBAS)...
July 18, 2018: European Archives of Psychiatry and Clinical Neuroscience
Golo Kronenberg, Markus Petermann, Christof Dormann, Michael Bader, Peter Gass, Rainer Hellweg, Friederike Klempin
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced...
July 17, 2018: European Archives of Psychiatry and Clinical Neuroscience
Sven Speerforck, F Dodoo-Schittko, S Brandstetter, C Apfelbacher, U Hapke, F Jacobi, H J Grabe, S E Baumeister, G Schomerus
BACKGROUND: Major depressive disorder (MDD) and bipolar disorder are associated with certain cardiovascular risk factors (CVRFs), but it is unclear whether they are associated with unfavourable changes of clinically manifest CVRFs over time. METHODS: We used baseline and 12-year follow-up (n = 1887) data from the German Health Interview and Examination Survey 1998. Multivariable linear regression models assessed associations between lifetime CIDI-diagnosed mood disorders at baseline and continuous risk factor-related outcomes (blood pressure, HbA1c, LDL-C, HDL-C, triglycerides, BMI) at follow-up...
July 16, 2018: European Archives of Psychiatry and Clinical Neuroscience
Kenji Hashimoto, Chun Yang
No abstract text is available yet for this article.
July 14, 2018: European Archives of Psychiatry and Clinical Neuroscience
Pegah Sarkheil, Martin Klasen, Frank Schneider, Rainer Goebel, Klaus Mathiak
Emotion regulation (ER) is crucial in terms of mental health and social functioning. Attention deployment (AD) and cognitive reappraisal (CR) are both efficient cognitive ER strategies, which are based on partially dissociated neural effects. Our understanding of the neural underpinnings of ER is based on laboratory paradigms that study changes of the brain activation related to isolated emotional stimuli. To track the neural response to ER in the changing and dynamic environment of daily life, we extended the common existing paradigms by applying a sequence of emotionally provocative stimuli involving three aversive images...
July 14, 2018: European Archives of Psychiatry and Clinical Neuroscience
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