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European Archives of Psychiatry and Clinical Neuroscience

A M Sánchez-Torres, L Moreno-Izco, R Lorente-Omeñaca, B Cabrera, A Lobo, A M González-Pinto, J Merchán-Naranjo, I Corripio, E Vieta, E de la Serna, A Butjosa, F Contreras, S Sarró, G Mezquida, M Ribeiro, M Bernardo, M J Cuesta
Individual changes over time in cognition in patients with psychotic disorders have been studied very little, especially in the case of first episode psychosis (FEP). We aimed to establish whether change in individual trajectories in cognition over 2 years of a sample of 159 FEP patients was reliable and clinically significant, using the reliable change index (RCI) and clinically significant change (CSC) methods. We also studied a sample of 151 matched healthy controls. Patients and controls were assessed with a set of neuropsychological tests, as well as premorbid, clinical and functionality measures...
November 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
Anna-Katharine Brem, Soili M Lehto, Daniel Keeser, Frank Padberg
No abstract text is available yet for this article.
November 20, 2017: European Archives of Psychiatry and Clinical Neuroscience
Frank Padberg, Anna-Katharine Brem, Ulrich Palm, Oliver Pogarell, Alkomiet Hasan, Jerôme Brunelin, Chris Baeken, Emmanuel Poulet, Berthold Langguth, Daniel Keeser
No abstract text is available yet for this article.
November 20, 2017: European Archives of Psychiatry and Clinical Neuroscience
Hans-Jürgen Möller, Hans-Peter Volz, Angelika Dienel, Sandra Schläfke, Siegfried Kasper
Subthreshold psychiatric disorders do not fully meet the diagnostic criteria of syndromal disorders but may be associated with comparable disability. To investigate the anxiolytic effect of Silexan, an active substance from lavender oil for oral administration, in patients with subthreshold anxiety, a meta-analysis that included all published trials with Silexan in this indication was performed. Three randomised, placebo-controlled trials in subthreshold anxiety disorders (anxiety disorder not otherwise specified, restlessness and agitation, mixed anxiety and depressive disorder) were included...
November 17, 2017: European Archives of Psychiatry and Clinical Neuroscience
Dan Edvinsson, Lisa Ekselius
There are very few studies on the long-term outcome in subjects diagnosed with ADHD as adults. The objective of the present study was to assess this and relate the outcome to whether there was current medication or not and to other potential predictors of favourable outcome. A prospective clinical cohort of adults diagnosed with ADHD according to DSM-IV criteria was followed-up on an average of 6 years after first evaluation (n = 124; mean age 42 years, 51% males). ADHD symptom trajectories were assessed as well as medication, global functioning, disability, health-related quality of life, and alcohol and drug consumption at follow-up...
November 15, 2017: European Archives of Psychiatry and Clinical Neuroscience
Mingli Li, Wei Deng, Tushar Das, Yinfei Li, Liansheng Zhao, Xiaohong Ma, Yingcheng Wang, Hua Yu, Xiaojing Li, Ya-Jing Meng, Qiang Wang, Lena Palaniyappan, Tao Li
Developing a mechanistic insight into the specific brain processes that underpin improvement in negative symptoms can help us design novel chemical and physical treatments against these unrelenting symptoms. The aim of the present study is to explore the longitudinal changes in the brain's regional functional efficiency that accompany improvement in negative symptoms seen in first-episode patients with schizophrenia when treated with antipsychotic for 1 year. Forty-seven first-episode patients with schizophrenia were scanned at a drug-naive baseline state and followed up for 1 year to identify negative symptom responders (Rn) and non-responders (NRn)...
November 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
G Fond, N Resseguier, F Schürhoff, O Godin, M Andrianarisoa, L Brunel, E Bulzacka, B Aouizerate, F Berna, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, C Lançon, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, L Boyer, M Leboyer
Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to increase inflammation while preclinical inconsistent findings have been found regarding the association with psychotropic drugs. The aim of this study was to explore if psychotropic drugs were associated with inflammation in SZ and to determine which psychotropic drug was associated with inflammation in stable SZ subjects while considering clinical confounding factors...
November 10, 2017: European Archives of Psychiatry and Clinical Neuroscience
Hans-Gert Bernstein, Bernhard Bogerts, Gerburg Keilhoff, Johann Steiner
No abstract text is available yet for this article.
November 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
Ji-Chun Zhang, Wei Yao, Chao Dong, Mei Han, Yukihiko Shirayama, Kenji Hashimoto
The transcription factor Keap1-Nrf2 signaling plays a key role in the oxidative stress which is involved in psychiatric disorders. In the learned helplessness (LH) paradigm, protein levels of Keap1 and Nrf2 in the prefrontal cortex and dentate gyrus of hippocampus from LH (susceptible) rats were lower than control and non-LH (resilience) rats. Furthermore, protein expressions of Keap1 and Nrf2 in the parietal cortex from major depressive disorder, schizophrenia, and bipolar disorder were lower than controls...
November 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
Marina Economou, Elena Dieti, Helen Lazaratou
No abstract text is available yet for this article.
October 26, 2017: European Archives of Psychiatry and Clinical Neuroscience
Tsutomu Takahashi, Mihoko Nakamura, Daiki Sasabayashi, Yuko Komori, Yuko Higuchi, Yumiko Nishikawa, Shimako Nishiyama, Hiroko Itoh, Yuri Masaoka, Michio Suzuki
Odor identification deficits are well documented in patients with schizophrenia, but it remains unclear whether individuals at clinical high-risk for psychosis exhibit similar changes and whether their olfactory function is related to social/cognitive functions and symptomatology. In this study, we investigated odor detection sensitivity and identification ability in 32 individuals with at-risk mental state (ARMS), 59 schizophrenia patients, and 169 healthy controls using a T&T olfactometer. The ARMS and schizophrenia subjects were administered the Brief Assessment of Cognition in Schizophrenia (BACS), the Schizophrenia Cognition Rating Scale (SCoRS), and the Social and Occupational Functioning Assessment Scale (SOFAS) to assess their cognitive and social functions, and the Positive and Negative Syndrome Scale (PANSS) for clinical symptoms...
October 25, 2017: European Archives of Psychiatry and Clinical Neuroscience
Isabella Schneider, Katja Bertsch, Natalie A Izurieta Hidalgo, Laura E Müller, Christian Schmahl, Sabine C Herpertz
According to longitudinal studies, most individuals with borderline personality disorder (BPD) achieve remission. Since BPD is characterized by disturbed emotion recognition, this study investigated behavioral and electrophysiological correlates of facial emotion classification and processing in remitted BPD. 32 women with remitted BPD (rBPD), 32 women with current BPD (cBPD), and 28 healthy women (HC) participated in an emotion classification paradigm comprising blends of angry and happy faces while behavioral and electroencephalographic (event-related potentials) data were recorded...
September 27, 2017: European Archives of Psychiatry and Clinical Neuroscience
Lena Sabaß, Frank Padberg, Claus Normann, Vera Engel, Carsten Konrad, Kristina Helmle, Andrea Jobst, Andrew Worlitz, Eva-Lotta Brakemeier
The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a relatively new approach in the treatment of chronic depression (CD). Adapted as group psychotherapy for inpatients, CBASP is attracting increasing attention. In this naturalistic multicenter trial, we investigated its feasibility after 10 sessions of CBASP group therapy over a treatment time of at least 5 to a maximum of 10 weeks. Treatment outcome was additionally assessed. Across four centers, 116 inpatients with CD (DSM-IV-TR) attended CBASP group psychotherapy...
September 27, 2017: European Archives of Psychiatry and Clinical Neuroscience
Tanya T Nguyen, Sheena I Dev, Guanqing Chen, Sharon C Liou, Averria Sirkin Martin, Michael R Irwin, Judith E Carroll, Xin Tu, Dilip V Jeste, Lisa T Eyler
Schizophrenia is associated with chronic low-grade inflammation, which has been linked to increased vascular risk and rates of cardiovascular disease. Levels of vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) have been related to aging and neurodegeneration, but their role in schizophrenia remains uncertain. Using a cross-sectional, case-control design, this study included 99 outpatients with schizophrenia and 99 healthy comparison subjects (HCs)...
September 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
Lisa Krech, Michael Belz, Matthias Besse, Isabel Methfessel, Dirk Wedekind, David Zilles
Electroconvulsive therapy (ECT) is the most effective therapy for severe depressive disorders. Though there are known clinical predictors of response (e.g., higher age, presence of psychotic symptoms), there is a lack of knowledge concerning the impact of patients' expectations on treatment outcome and tolerability in terms of possible placebo/nocebo effects. In 31 patients with unipolar or bipolar depressive disorder, we used a questionnaire to investigate the patients' expectations of ECT effectiveness and tolerability prior to and in the course of the treatment...
September 22, 2017: European Archives of Psychiatry and Clinical Neuroscience
Ashley M Schnakenberg Martin, Lisa Bartolomeo, Josselyn Howell, William P Hetrick, Amanda R Bolbecker, Alan Breier, Gary Kidd, Brian F O'Donnell
Schizophrenia spectrum disorder (SZ) is associated with deficits in auditory perception as well as auditory verbal hallucinations (AVH). However, the relationship between auditory feature perception and auditory verbal hallucinations (AVH), one of the most commonly occurring symptoms in psychosis, has not been well characterized. This study evaluated perception of a broad range of auditory features in SZ and determined whether current AVHs relate to auditory feature perception. Auditory perception, including frequency, intensity, duration, pulse-train and temporal order discrimination, as well as an embedded tone task, was assessed in both AVH (n = 20) and non-AVH (n = 24) SZ individuals and in healthy controls (n = 29) with the Test of Basic Auditory Capabilities (TBAC)...
September 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
Nevin F W Zaki, David Warren Spence, Ahmed S BaHammam, Seithikurippu R Pandi-Perumal, Daniel P Cardinali, Gregory M Brown
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms...
September 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
Julie Nordgaard, Lars Siersbæk Nilsson, Ditte Sæbye, Josef Parnas
Self-disorders have been hypothesized to be an underlying and trait-like core feature of schizophrenia-spectrum disorders and a certain degree of temporal stability of self-disorders would therefore be expected. The aim of the study was to examine the persistence of self-disorders measured by the Examination of Anomalous Self Experiences over a time span of 5 years. 48 patients with schizophrenia-spectrum disorders were thoroughly assessed for psychopathology at baseline and 5 years later. Self-disorders were assessed by the Examination of Anomalous Self Experiences...
September 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
Alana C Costa, Helena P G Joaquim, Valéria S Nunes, Daniel S Kerr, Guilherme S Ferreira, Orestes V Forlenza, Wagner F Gattaz, Leda Leme Talib
Cholesterol is an essential component in the structure and function of cell membranes and has been associated with the major pathological signatures of Alzheimer's disease (AD). To maintain brain cholesterol homeostasis, it is converted into 24(S)-hydroxycholesterol (24OHC) which can be driven through the blood-brain barrier. Several studies have already described a decrease in 24OHC and an increase of 27(S)-hydroxycholesterol (27OHC) in AD, as a reflection of disease burden, the loss of metabolically active neurons and the degree of structural atrophy...
August 31, 2017: European Archives of Psychiatry and Clinical Neuroscience
Alessandra Sussulini, Helena Munhoz Erbolato, Gustavo de Souza Pessôa, Marco Aurélio Zezzi Arruda, Johann Steiner, Daniel Martins-de-Souza
Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medication using an elemental fingerprinting strategy. We evaluated 56 plasma samples from schizophrenia patients by inductively coupled plasma mass spectrometry (ICP-MS) before (t0) and after 6 weeks (t6) of treatment...
August 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
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