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European Archives of Psychiatry and Clinical Neuroscience

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https://www.readbyqxmd.com/read/28936548/auditory-feature-perception-and-auditory-hallucinatory-experiences-in-schizophrenia-spectrum-disorder
#1
Ashley M Schnakenberg Martin, Lisa Bartolomeo, Josselyn Howell, William P Hetrick, Amanda R Bolbecker, Alan Breier, Gary Kidd, Brian F O'Donnell
Schizophrenia spectrum disorder (SZ) is associated with deficits in auditory perception as well as auditory verbal hallucinations (AVH). However, the relationship between auditory feature perception and auditory verbal hallucinations (AVH), one of the most commonly occurring symptoms in psychosis, has not been well characterized. This study evaluated perception of a broad range of auditory features in SZ and determined whether current AVHs relate to auditory feature perception. Auditory perception, including frequency, intensity, duration, pulse-train and temporal order discrimination, as well as an embedded tone task, was assessed in both AVH (n = 20) and non-AVH (n = 24) SZ individuals and in healthy controls (n = 29) with the Test of Basic Auditory Capabilities (TBAC)...
September 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28894915/chronobiological-theories-of-mood-disorder
#2
Nevin F W Zaki, David Warren Spence, Ahmed S BaHammam, Seithikurippu R Pandi-Perumal, Daniel P Cardinali, Gregory M Brown
Major depressive disorder (MDD) remains the most prevalent mental disorder and a leading cause of disability, affecting approximately 100 million adults worldwide. The disorder is characterized by a constellation of symptoms affecting mood, anxiety, neurochemical balance, sleep patterns, and circadian and/or seasonal rhythm entrainment. However, the mechanisms underlying the association between chronobiological parameters and depression remain unknown. A PubMed search was conducted to review articles from 1979 to the present, using the following search terms: "chronobiology," "mood," "sleep," and "circadian rhythms...
September 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28865064/self-disorders-in-schizophrenia-spectrum-disorders-a-5-year-follow-up-study
#3
Julie Nordgaard, Lars Siersbæk Nilsson, Ditte Sæbye, Josef Parnas
Self-disorders have been hypothesized to be an underlying and trait-like core feature of schizophrenia-spectrum disorders and a certain degree of temporal stability of self-disorders would therefore be expected. The aim of the study was to examine the persistence of self-disorders measured by the Examination of Anomalous Self Experiences over a time span of 5 years. 48 patients with schizophrenia-spectrum disorders were thoroughly assessed for psychopathology at baseline and 5 years later. Self-disorders were assessed by the Examination of Anomalous Self Experiences...
September 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28861608/donepezil-effects-on-cholesterol-and-oxysterol-plasma-levels-of-alzheimer-s-disease-patients
#4
Alana C Costa, Helena P G Joaquim, Valéria S Nunes, Daniel S Kerr, Guilherme S Ferreira, Orestes V Forlenza, Wagner F Gattaz, Leda Leme Talib
Cholesterol is an essential component in the structure and function of cell membranes and has been associated with the major pathological signatures of Alzheimer's disease (AD). To maintain brain cholesterol homeostasis, it is converted into 24(S)-hydroxycholesterol (24OHC) which can be driven through the blood-brain barrier. Several studies have already described a decrease in 24OHC and an increase of 27(S)-hydroxycholesterol (27OHC) in AD, as a reflection of disease burden, the loss of metabolically active neurons and the degree of structural atrophy...
August 31, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28852835/elemental-fingerprinting-of-schizophrenia-patient-blood-plasma-before-and-after-treatment-with-antipsychotics
#5
Alessandra Sussulini, Helena Munhoz Erbolato, Gustavo de Souza Pessôa, Marco Aurélio Zezzi Arruda, Johann Steiner, Daniel Martins-de-Souza
Antipsychotics are the main line of treatment for schizophrenia, a disorder that affects about 1% of the worldwide population. Considering the poor performance of antipsychotics on patients, this work aimed at detecting alterations in the elemental profile resulting from the use of this type of medication using an elemental fingerprinting strategy. We evaluated 56 plasma samples from schizophrenia patients by inductively coupled plasma mass spectrometry (ICP-MS) before (t0) and after 6 weeks (t6) of treatment...
August 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28828697/metacognitive-training-in-patients-recovering-from-a-first-psychosis-an-experience-sampling-study-testing-treatment-effects
#6
Karin Pos, Carin J Meijer, Oukje Verkerk, Onno Ackema, Lydia Krabbendam, Lieuwe de Haan
Cognitive biases, negative affect and negative self-esteem are associated with paranoia in people with psychotic disorders. Metacognitive group training (MCT) aims to target these biases although research has shown mixed results. Our objective was to establish the effect of MCT on paranoid ideation in patients with recent onset psychosis in a powerful experience sampling design. 50 patients between the age of 18 and 35 were included in a single-blind, parallel group RCT comparing MCT with occupational therapy (OT) as an active control condition...
August 21, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28803349/scary-symptoms-functional-magnetic-resonance-imaging-evidence-for-symptom-interpretation-bias-in-pathological-health-anxiety
#7
Zhimin Yan, Michael Witthöft, Josef Bailer, Carsten Diener, Daniela Mier
Patients with pathological health anxiety (PHA) tend to automatically interpret bodily sensations as sign of a severe illness. To elucidate the neural correlates of this cognitive bias, we applied an functional magnetic resonance imaging adaption of a body-symptom implicit association test with symptom words in patients with PHA (n = 32) in comparison to patients with depression (n = 29) and healthy participants (n = 35). On the behavioral level, patients with PHA did not significantly differ from the control groups...
August 12, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28801847/assessment-of-functioning-and-disability-in-patients-with-schizophrenia-using-the-who-disability-assessment-schedule-2-0-in-a-large-scale-database
#8
Ruey Chen, Tsan-Hon Liou, Kwang-Hwa Chang, Chia-Feng Yen, Hua-Fang Liao, Wen-Chou Chi, Kuei-Ru Chou
Schizophrenia is a common mental disorder characterized by deficits in multiple domains of functioning. This study is arguably the first of its kind in Taiwan to examine, in a multifaceted and objective manner, the disability of patients with schizophrenia and the factors affecting it. A cross-sectional design was adopted to gather data from 24,299 patients with schizophrenia who were listed in the Taiwan Databank of Persons with Disabilities. The level of disability in these patients was measured using the World Health Organization Disability Assessment Schedule 2...
August 11, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28791485/effectiveness-and-cost-effectiveness-of-an-integrated-care-program-for-schizophrenia-an-analysis-of-routine-data
#9
Linda Kerkemeyer, Jürgen Wasem, Anja Neumann, Werner Brannath, Benjamin Mester, Jürgen Timm, Thomas Wobrock, Claudia Bartels, Peter Falkai, Janine Biermann
In Germany, a regional social health insurance fund provides an integrated care program for patients with schizophrenia (IVS). Based on routine data of the social health insurance, this evaluation examined the effectiveness and cost-effectiveness of the IVS compared to the standard care (control group, CG). The primary outcome was the reduction of psychiatric inpatient treatment (days in hospital), and secondary outcomes were schizophrenia-related inpatient treatment, readmission rates, and costs. To reduce selection bias, a propensity score matching was performed...
August 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28770370/exploring-deficient-emotion-regulation-in-adult-adhd-electrophysiological-evidence
#10
Anna Shushakova, Patricia Ohrmann, Anya Pedersen
Emotional dysregulation (ED) is being increasingly recognized as a core feature of attention-deficit/hyperactivity disorder (ADHD), but the pathophysiological underpinnings remain unclear. In this study, we provide meaningful electrophysiological evidence of ED in adult patients with ADHD (n = 39) compared to healthy controls (n = 40) by exploring the electrophysiological correlates of the emotion regulation strategies reappraisal, distraction, and expressive suppression. Event-related potentials (ERPs) were recorded during passive viewing of neutral and negative images, as well as during emotion regulation...
August 2, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28766129/use-and-safety-of-antiepileptic-drugs-in-psychiatric-inpatients-data-from-the-amsp-study
#11
Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R Engel, Alexandra Kleimann, Susanne Stübner, Waldemar Greil, Sermin Toto
The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%...
August 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28766128/the-influence-of-generalized-anxiety-disorder-on-executive-functions-in-children-with-adhd
#12
D Menghini, M Armando, M Calcagni, C Napolitano, P Pasqualetti, J A Sergeant, P Pani, S Vicari
The present study was aimed at verifying whether the presence of generalized anxiety disorder (GAD) affects executive functions in children with attention-deficit hyperactivity disorder (ADHD). Two groups of children with ADHD were selected for the study according to the presence or absence of GAD. The first group of 28 children with ADHD with GAD (mean age: 9 ± 1.2; males/females: 24/4) was matched for gender, age, IQ, psychiatric comorbidity with a second group of 29 children with ADHD without GAD (mean age: 8...
August 1, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28761988/neurological-soft-signs-precede-the-onset-of-schizophrenia-a-study-of-individuals-with-schizotypy-ultra-high-risk-individuals-and-first-onset-schizophrenia
#13
Raymond C K Chan, Hui-Ru Cui, Min-Yi Chu, Tian-Hong Zhang, Ya Wang, Yi Wang, Zhi Li, Simon S Y Lui, Ji-Jun Wang, Eric F C Cheung
Neurological soft signs (NSS) are one of the biomarkers for schizophrenia spectrum disorders. However, a few studies have examined the prevalence of NSS across the schizophrenia spectrum. The present study adopted a quasi-longitudinal study design and examined the prevalence of NSS and their associations with clinical and behavioural manifestations in participants in different stages of the illness. The abridged version of the Cambridge Neurological Inventory was administered to 39 patients with the first-episode schizophrenia, 39 individuals with ultra-high risk (UHR) for psychosis, 39 individuals with schizotypy, and 39 healthy controls...
July 31, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28756468/the-impact-of-cognitive-insight-self-stigma-and-medication-compliance-on-the-quality-of-life-in-patients-with-schizophrenia
#14
Yin-Ju Lien, Hsin-An Chang, Yu-Chen Kao, Nian-Sheng Tzeng, Chien-Wen Lu, Ching-Hui Loh
Impaired quality of life (QoL) is a common and clinically relevant feature of schizophrenia. In the present study, we attempted to formulate a model of QoL in the chronic stage of schizophrenia by including key variables-namely cognitive insight, self-stigma, insight into treatment, and medication compliance-that were proposed as its significant predictors in previous studies. We employed structural equation modeling (SEM) to simultaneously test the associations between these variables. A total of 170 community-dwelling patients with schizophrenia participated in this study...
July 29, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28725951/new-aspects-of-the-vulnerability-stress-model-in-general-its-relevance-in-schizophrenic-psychoses-and-the-place-of-antipsychotics
#15
EDITORIAL
Hans-Jürgen Möller
No abstract text is available yet for this article.
July 19, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28712090/does-prior-traumatization-affect-the-treatment-outcome-of-cbt-for-panic-disorder-the-potential-role-of-the-maoa-gene-and-depression-symptoms
#16
Sebastian Trautmann, Jan Richter, Markus Muehlhan, Michael Höfler, Hans-Ulrich Wittchen, Katharina Domschke, Andreas Ströhle, Alfons O Hamm, Heike Weber, Tilo Kircher, Volker Arolt, Alexander L Gerlach, Georg W Alpers, Thomas Fydrich, Thomas Lang, Andreas Reif
Although cognitive behavioral therapy (CBT) is highly effective in the treatment of anxiety disorders, many patients still do not benefit. This study investigates whether a history of traumatic event experience is negatively associated with outcomes of CBT for panic disorder. The moderating role of the monoamine oxidase A (MAOA) gene and depression symptoms as well as the association between trauma history and fear reactivity as a potential mechanism are further analyzed. We conducted a post-hoc analysis of 172 male and 60 female patients with panic disorder treated with CBT in a multi-center study...
July 15, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28712089/increased-recruitment-of-cognitive-control-in-the-presence-of-traumatic-stimuli-in-complex-ptsd
#17
Julia I Herzog, Inga Niedtfeld, Sophie Rausch, Janine Thome, Meike Mueller-Engelmann, Regina Steil, Kathlen Priebe, Martin Bohus, Christian Schmahl
A neurocircuitry model of post-traumatic stress disorder (PTSD) suggests increased amygdala responses to emotional stimuli, coupled with hypoactivation of prefrontal regions associated with cognitive control. However, results are heterogenous across different subsamples of PTSD as well as different paradigms. We investigated cognitive control in a classic and emotional Stroop task in 28 female patients with complex PTSD (cPTSD), 28 female trauma-exposed healthy controls (TCs) and 28 female non-trauma-exposed healthy controls (HCs) using functional neuroimaging...
July 15, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28785817/6th-european-conference-on-schizophrenia-research-advancing-research-promoting-recovery-14-16-september-2017-berlin-germany
#18
(no author information available yet)
No abstract text is available yet for this article.
September 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28474230/erratum-to-high-levels-of-neuroticism-are-associated-with-decreased-cortical-folding-of-the-dorsolateral-prefrontal-cortex
#19
C Christoph Schultz, Heide Warziniak, Kathrin Koch, Claudia Schachtzabel, Daniel Güllmar, Jürgen R Reichenbach, Ralf G Schlösser, Heinrich Sauer, Gerd Wagner
No abstract text is available yet for this article.
September 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28593328/abnormalities-in-the-brain-immune-system-in-psychotic-disorders-from-pathogenesis-to-prevention
#20
EDITORIAL
Kenji Hashimoto
No abstract text is available yet for this article.
August 2017: European Archives of Psychiatry and Clinical Neuroscience
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