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European Archives of Psychiatry and Clinical Neuroscience

LeHoa Nguyen, Shingo Kakeda, Asuka Katsuki, Koichiro Sugimoto, Yuka Otsuka, Issei Ueda, Ryohei Igata, Keita Watanabe, Taro Kishi, Nakao Iwata, Yukunori Korogi, Reiji Yoshimura
Vascular endothelial growth factor (VEGF) is involved in the development of major depressive disorder (MDD). Recently, a genome-wide association study has revealed that four VEGF-related single nucleotide polymorphisms (SNPs) (i.e., rs4416670, rs6921438, rs6993770 and rs10738760) were independently associated with circulating VEGF levels. The current study investigated the relationship between brain volume and these four SNPs in first-episode drug-naïve MDD patients. A total of 38 first-episode drug-naïve MDD patients and 39 healthy subjects (HS) were recruited and underwent high-resolution T1-weighted imaging...
November 7, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ping Chai Koo, Christoph Berger, Golo Kronenberg, Julia Bartz, Peter Wybitul, Olaf Reis, Jacqueline Hoeppner
The diagnosis of major depressive disorder (MDD) should be based on multimodal evidence, because MDD not only affects mood, but also psychomotor and cognitive functions. Clinical markers such as executive dysfunctions and a reduction in daily motor activity have been observed in MDD. Neurophysiological biomarkers have also been described. In this study, we investigate the utility of combining biomarkers related to executive dysfunctions, motor activity, neurophysiological patterns (i.e. alpha power asymmetry and EEG-vigilance as indicators of brain arousal), and the interaction of these parameters in the diagnosis of MDD...
November 3, 2018: European Archives of Psychiatry and Clinical Neuroscience
Marina Economou, Kyriakos Souliotis, Lily Evangelia Peppou, Yiannis Dimopoulos
No abstract text is available yet for this article.
November 1, 2018: European Archives of Psychiatry and Clinical Neuroscience
F Markus Leweke, Stefan Bleich, Udo Schneider
No abstract text is available yet for this article.
November 1, 2018: European Archives of Psychiatry and Clinical Neuroscience
Peter Falkai, Andrea Schmitt, Nikolaos Koutsouleris
No abstract text is available yet for this article.
October 29, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ahmet Zihni Soyata, Serkan Aksu, Adam J Woods, Pınar İşçen, Kardelen Türkü Saçar, Sacit Karamürsel
Decision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder...
October 26, 2018: European Archives of Psychiatry and Clinical Neuroscience
Stephanie N L Schmidt, Sabrina C Fenske, Peter Kirsch, Daniela Mier
Aberrant salience may explain hasty decision making and psychotic symptoms in schizophrenia. In healthy individuals, final decisions in probabilistic reasoning tasks are related to Nucleus accumbens (Nacc) activation. However, research investigating the Nacc in social decision making is missing. Our study aimed at investigating the role of the Nacc for social decision making and its link to (aberrant) salience attribution. 47 healthy individuals completed a novel social jumping-to-conclusion (JTC) fMRI-paradigm, showing morphed faces simultaneously expressing fear and happiness...
October 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
Frauke Schultze-Lutter, Stephan Ruhrmann, Chantal Michel, Jochen Kindler, Benno G Schimmelmann, Stefanie J Schmidt
Reports of limited clinical significance of attenuated psychotic symptoms before age 15/16 indicate an important role of neurodevelopment in the early detection of psychoses. Therefore, we examined if age also exerts an influence on the prevalence and clinical significance of the 14 cognitive and perceptive basic symptoms (BS) used in psychosis-risk criteria and conceptualized as the most direct self-experienced expression of neurobiological aberrations. A random representative general population sample of the Swiss canton Bern (N = 689, age 8-40 years, 06/2011-05/2014) was interviewed for BS, psychosocial functioning, and current mental disorder...
October 25, 2018: European Archives of Psychiatry and Clinical Neuroscience
Daniel Pagnin, Maria Luiza Zamboni Grecco, Erikson Felipe Furtado
The objective of the study was to investigate the association between alcohol use during pregnancy and mental disorders in childhood, controlling for confounding risk factors by a longitudinal study of pregnant women and their offspring. The initial cohort comprised pregnant women attending an obstetric service. From the initial sample of 449 pregnant women, 81 mother-child pairs agreed to participate. After 12 years, mother-child pairs were assessed through self-administered questionnaires and semi-structured interviews...
October 23, 2018: European Archives of Psychiatry and Clinical Neuroscience
Meng Li, Marie Woelfer, Lejla Colic, Adam Safron, Catie Chang, Hans-Jochen Heinze, Oliver Speck, Helen S Mayberg, Bharat B Biswal, Giacomo Salvadore, Anna Fejtova, Martin Walter
Ketamine exerts rapid antidepressant effects peaking 24 h after a single infusion, which have been suggested to be reflected by both reduced functional connectivity (FC) within default mode network (DMN) and altered glutamatergic levels in the perigenual anterior cingulate cortex (pgACC) at 24 h. Understanding the interrelation and time point specificity of ketamine-induced changes of brain circuitry and metabolism is thus key to future therapeutic developments. We investigated the correlation of late glutamatergic changes with FC changes seeded from the posterior cingulate cortex (PCC) and tested the prediction of the latter by acute fractional amplitude of low-frequency fluctuations (fALFF)...
October 23, 2018: European Archives of Psychiatry and Clinical Neuroscience
Anne Gärtner, Denise Dörfel, Kersten Diers, Stephanie H Witt, Alexander Strobel, Burkhard Brocke
Recent translational studies identified a common endocannabinoid polymorphism, FAAH C385A, in the gene for the fatty acid amide hydrolase (FAAH). This polymorphism alters endocannabinoid anandamide levels, which are known to be involved in the fronto-amygdala circuitry implicated in mood regulation and anxiety-like behaviors. While it has been shown that the variant that selectively enhances fronto-amygdala connectivity at rest is associated with decreased anxiety-like behaviors, no study so far has investigated whether this finding of FAAH-related differential plasticity extends to task-related differential functional expression and regulation during negative emotional processing...
October 5, 2018: European Archives of Psychiatry and Clinical Neuroscience
Susanne Neufang, Maximilian J Geiger, György A Homola, Marina Mahr, Miriam A Schiele, Andrea Gehrmann, Brigitte Schmidt, Agnieszka Gajewska, Johannes Nowak, Eva Meisenzahl-Lechner, Mirko Pham, Marcel Romanos, Atae Akhrif, Katharina Domschke
Given the particular relevance of arousal and alerting in panic disorder (PD), here the alerting network was investigated (1) contrasting patients with PD and healthy controls, (2) as a function of anxiety sensitivity constituting a dimensional measure of panic-related anxiety, and (3) as a possible correlate of treatment response. Using functional magnetic resonance imaging (fMRI), 45 out-patients with PD (f = 34) and 51 matched healthy controls were investigated for brain activation patterns and effective connectivity (Dynamic Causal Modeling, DCM) while performing the Attention Network Task (ANT)...
October 4, 2018: European Archives of Psychiatry and Clinical Neuroscience
Tilo Kircher, Markus Wöhr, Igor Nenadic, Rainer Schwarting, Gerhard Schratt, Judith Alferink, Carsten Culmsee, Holger Garn, Tim Hahn, Bertram Müller-Myhsok, Astrid Dempfle, Maik Hahmann, Andreas Jansen, Petra Pfefferle, Harald Renz, Marcella Rietschel, Stephanie H Witt, Markus Nöthen, Axel Krug, Udo Dannlowski
Genetic (G) and environmental (E) factors are involved in the etiology and course of the major psychoses (MP), i.e. major depressive disorder (MDD), bipolar disorder (BD), schizoaffective disorder (SZA) and schizophrenia (SZ). The neurobiological correlates by which these predispositions exert their influence on brain structure, function and course of illness are poorly understood. In the FOR2107 consortium, animal models and humans are investigated. A human cohort of MP patients, healthy subjects at genetic and/or environmental risk, and control subjects (N = 2500) has been established...
September 28, 2018: European Archives of Psychiatry and Clinical Neuroscience
Moritz Bruno Petzold, Jennifer Lara Maria Mumm, Sophie Bischoff, Julia Große, Jens Plag, Ralf Brand, Andreas Ströhle
INTRODUCTION: While physical activity (PA) can play an important role in the treatment of mental disorders (MD), large proportions of patients with MD do not meet PA recommendations. The aim of this trial was to evaluate whether structured psychological intervention (MoVo-LISA) is effective in helping outpatients with MD to increase their level of PA. As active control group (CG) we modified MoVo-LISA to target healthy diet behavior. METHODS: N = 83 outpatients with MD (F1-F4) were randomized to the two conditions...
September 8, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ulf J Müller, Christian Mawrin, Thomas Frodl, Henrik Dobrowolny, Stefan Busse, Hans-Gert Bernstein, Bernhard Bogerts, Kurt Truebner, Johann Steiner
Deep brain stimulation (DBS) of the globus pallidus internus was recently proposed as a potential new treatment target for opioid addiction. DBS requires computer-assisted-3D planning to implant the stimulation electrode precisely. As volumes of brain regions may differ in addiction compared to healthy controls, our aim was to investigate possible volume differences in addicts compared to healthy controls. Volumes of the globus pallidus externus (PE) and internus (PI) in heroin addicts (n = 14) and healthy controls (n = 12) were assessed using morphometry of serial whole-brain sections...
September 1, 2018: European Archives of Psychiatry and Clinical Neuroscience
Èlia Vila, Elena Huerta-Ramos, Christian Núñez, Judith Usall, Belén Ramos
Accumulating evidence suggests that Specificity Protein 1 (SP1) and 4 (SP4) transcription factors are involved in the pathophysiology of schizophrenia. The therapeutic use of selective oestrogen modulators such as raloxifene added to antipsychotic drugs in the treatment of postmenopausal women with schizophrenia has been investigated in a few clinical trials, which reported an improvement in negative, positive, and general psychopathological symptoms. We aimed to investigate the possible association between peripheral SP protein levels and symptom improvement in postmenopausal women with schizophrenia treated with adjuvant raloxifene...
August 30, 2018: European Archives of Psychiatry and Clinical Neuroscience
Hubertus Himmerich, Matthew Hotopf, Hitesh Shetty, Ulrike Schmidt, Janet Treasure, Richard D Hayes, Robert Stewart, Chin-Kuo Chang
Anorexia nervosa (AN) is found associated with increased mortality. Frequent comorbidities of AN include substance use disorders (SUD), affective disorders (AD) and personality disorders (PD). We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders in the observation window between January 2007 and March 2016 for 1970 people with AN, using data from the case register of the South London and Maudsley (SLaM) NHS Foundation Trust, an almost monopoly-secondary mental healthcare service provider in southeast London...
August 17, 2018: European Archives of Psychiatry and Clinical Neuroscience
Stefan Leucht, S Z Levine, M Samara, A Cipriani, J M Davis, T A Furukawa
No abstract text is available yet for this article.
October 2018: European Archives of Psychiatry and Clinical Neuroscience
Valéria de Almeida, Daniel Martins-de-Souza
Clinical and neurobiological findings have reported the involvement of endocannabinoid signaling in the pathophysiology of schizophrenia. This system modulates dopaminergic and glutamatergic neurotransmission that is associated with positive, negative, and cognitive symptoms of schizophrenia. Despite neurotransmitter impairments, increasing evidence points to a role of glial cells in schizophrenia pathobiology. Glial cells encompass three main groups: oligodendrocytes, microglia, and astrocytes. These cells promote several neurobiological functions, such as myelination of axons, metabolic and structural support, and immune response in the central nervous system...
October 2018: European Archives of Psychiatry and Clinical Neuroscience
Marc Krause, Yikang Zhu, Maximilian Huhn, Johannes Schneider-Thoma, Irene Bighelli, Adriani Nikolakopoulou, Stefan Leucht
BACKGROUND: Negative symptoms are the core of schizophrenia, but whether antipsychotics are efficacious for their treatment is unclear. Moreover, there is debate whether patients in relevant trials should have predominant negative symptoms or whether prominent negative symptoms are also acceptable. METHODS: We systematically reviewed randomised, blinded antipsychotic drug trials in patients with schizophrenia and either predominant or prominent negative symptoms (last search Dec 12, 2017)...
October 2018: European Archives of Psychiatry and Clinical Neuroscience
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