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Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging

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https://www.readbyqxmd.com/read/30232810/teriflunomide-s-effect-on-glia-in-experimental-demyelinating-disease-a-neuroimaging-and-histologic-study
#1
Suyog Pol, Michele Sveinsson, Michelle Sudyn, Natan Babek, Danielle Siebert, Nicola Bertolino, Claire M Modica, Marilena Preda, Ferdinand Schweser, Robert Zivadinov
BACKGROUND AND PURPOSE: Teriflunomide reduces disability progression and brain atrophy in multiple sclerosis patients. The exact mechanism of action by which teriflunomide exerts these effects is currently unknown. We assessed the effect of teriflunomide on brain glial cells in the Theiler's murine encephalomyelitis virus (TMEV) by using a histological approach in combination with neuroimaging. METHODS: Forty-eight SJL female mice received an intracerebral injection of TMEV at 6-8 weeks of age and were then treated with teriflunomide (n = 24) or placebo (n = 24) for 9 months...
September 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30230638/multicenter-measurements-of-t-1-relaxation-and-diffusion-tensor-imaging-intra-and-intersite-reproducibility
#2
Irene M Vavasour, Sandra M Meyers, Burkhard Mädler, Trudy Harris, Eric Fu, David K B Li, Anthony Traboulsee, Alex L MacKay, Cornelia Laule
BACKGROUND AND PURPOSE: Quantitative T1 and diffusion tensor imaging (DTI) may provide information about pathological changes underlying disability and progression in diseases like multiple sclerosis (MS). Imaging the corpus callosum (CC), a primary site of damage in MS with a critical role in interhemispheric connectivity, may be useful for assessing overall brain health, prognosis, and therapy efficacy. We assessed the feasibility of multisite clinical trials using advanced MRI by examining the intra and intersite reproducibility of T1 and DTI measurements in the CC and segmented white matter (WM)...
September 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30230118/18f-fpeb-pet-ct-shows-mglur5-upregulation-in-parkinson-s-disease
#3
Yeona Kang, Claire Henchcliffe, Ajay Verma, Shankar Vallabhajosula, Bin He, Paresh J Kothari, Kane O Pryor, P David Mozley
BACKGROUND AND PURPOSE: Dopamine and glutamate reciprocally regulate each other in some of the neurocircuits affected by Parkinson's disease (PD). The objective of this pilot study was to explore relationships between these neurotransmitter systems with positron emission tomography. METHODS: The sample consisted of nine patients with PD and eight healthy volunteers (HVs). Dynamic images of the brain were acquired after the IV administration of ∼370 MBq (10 mCi) of [11 C]PE2i, a dopamine transporter (DaT) imaging agent, and ∼185 MBq (∼5 mCi) of [18 F]FPEB, a selective metabotropic glutamate receptor 5 (mGluR5) antagonist...
September 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30230093/baseline-aspects-and-e-aspects-correlation-with-infarct-volume-and-functional-outcome-in-patients-undergoing-mechanical-thrombectomy
#4
Marta Olive-Gadea, Nuno Martins, Sandra Boned, Jaime Carvajal, Maria Jose Moreno, Marian Muchada, Carlos A Molina, Alejandro Tomasello, Marc Ribo, Marta Rubiera
BACKGROUND AND PURPOSE: The role of Alberta Stroke Program Early CT score (ASPECTS) in predicting which patients are likely to benefit from endovascular therapy (EVT) is not well defined. An automated software (e-ASPECTS) has been created to solve its poor interrater reliability. We aim to evaluate correlation between radiologist (Rx) and e-ASPECTS scoring with cerebral blood volume (CBV) infarct core and with final infarct volume; as well as with long-term functional outcome. METHODS: We included patients with acute ischemic stroke and large vessel occlusion who underwent EVT...
September 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30230091/ct-reconstruction-levels-affect-automated-and-reader-based-aspects-ratings-in-acute-ischemic-stroke
#5
Fatih Seker, Johannes Pfaff, Simon Nagel, Dominik Vollherbst, Stephen Gerry, Markus A Möhlenbruch, Martin Bendszus, Christian Herweh
BACKGROUND AND PURPOSE: We investigated whether automated and reader-based ASPECTS in acute stroke patients are affected by different CT image reconstruction algorithms. METHODS: ASPECTS were assessed by commercial software and four independent blinded readers (two residents and two consultants) from different CT reconstructions (filtered back projection and two different iterative reconstruction [IR] levels) in 43 acute stroke patients with proximal middle cerebral artery occlusion...
September 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30209849/mri-profile-and-collateral-status-in-patients-with-a-transient-ischemic-attack-and-an-intracranial-artery-occlusion
#6
Elodie Ong, Omer Eker, Leila Chamard, Tae Hee Cho, Laurent Derex, Marielle Buisson, Laura Mechtouff, Yves Berthezene, Norbert Nighoghossian
BACKGROUND AND PURPOSE: Transient ischemic attack may rarely reveal an intracranial artery occlusion. We analyzed acute magnetic resonance imaging (MRI) patterns and early outcome after reperfusion therapy in these cases. METHOD: Clinical and imaging data were taken retrospectively from our comprehensive stroke center registry. Two MRI patterns were determined. Pattern A: full mismatch with negative diffusion-weighted imaging (DWI) and perfusion defect. Pattern B: large mismatch with positive DWI and perfusion defect...
September 12, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30198601/prospective-study-of-the-clinical-electrophysiologic-and-sonographic-characteristics-of-oxaliplatin-induced-neuropathy
#7
Kalliopi Pitarokoili, Nadine Höffken, Niko Lönneker, Anna Lena Fisse, Nadine Trampe, Ralf Gold, Anke Reinacher-Schick, Min-Suk Yoon
BACKGROUND AND PURPOSE: Oxaliplatin-induced neuropathy is a major dose limiting side effect of the highly effective combination chemotherapy with oxaliplatin, irinotecan, and 5-fluorouracil (FOLFIRINOX) in patients with metastastic pancreatic cancer. We present the first longitudinal sonographical-electrophysiological study on oxaliplatin-induced neuropathy. METHODS: Thirteen patients with metastatic pancreatic cancer underwent clinical, sonographic, and electrophysiological evaluation before, 3 and 7 months after treatment with 12 two-week cycles of FOLFIRINOX...
September 10, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30160814/white-matter-degeneration-after-ischemic-stroke-a-longitudinal-diffusion-tensor-imaging-study
#8
Milanka M Visser, Nawaf Yassi, Bruce C V Campbell, Patricia M Desmond, Stephen M Davis, Neil Spratt, Mark Parsons, Andrew Bivard
BACKGROUND AND PURPOSE: Degeneration of gray matter and subcortical structures after ischemic stroke has been well described. However, little is known about white matter degeneration after stroke. It is unclear whether white matter degeneration occurs throughout the whole brain, or whether patterns of degeneration occur more in specific brain areas. METHODS: We prospectively collected National Institutes of Health Stroke Scale (NIHSS) scores and diffusion tensor imaging (DTI) in patients with acute ischemic stroke within the first week after onset (baseline), and at 1 and 3 months...
August 30, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30125430/prevalence-patterns-and-clinical-relevance-of-hypoxic-ischemic-injuries-in-children-exposed-to-abusive-head-trauma
#9
Emanuele Orru', Thierry A G M Huisman, Izlem Izbudak
BACKGROUND AND PURPOSE: Hypoxic-ischemic injuries (HIIs) are a scarcely investigated but important cause of morbidity and mortality in children who suffered abusive head trauma (AHT). The purpose of this study is to determine: (a) prevalence, types, and clinical relevance of cytotoxic edema compatible with HII in nonpenetrating AHT, (b) their relationship to other classic neuroimaging findings of AHT, and (c) their correlation with clinical outcomes. METHODS: Diffusion-weighted imaging sequences of magnetic resonance imagings performed on children under 5 years diagnosed with AHT were reviewed to detect the most common patterns of acute parenchymal damage...
August 19, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30102003/spinal-cord-atrophy-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#10
Courtney Casserly, Estelle E Seyman, Paula Alcaide-Leon, Melanie Guenette, Carrie Lyons, Stephanie Sankar, Anton Svendrovski, Stefan Baral, Jiwon Oh
BACKGROUND AND PURPOSE: Spinal cord atrophy (SCA) is an important emerging outcome measure in multiple sclerosis (MS); however, there is limited consensus on the magnitude and rate of atrophy. The objective of this study was to synthesize the available data on measures of SCA in MS. METHODS: Using published guidelines, relevant literature databases were searched between 1977 and 2017 for case-control or cohort studies reporting a quantitative measure of SCA in MS patients...
August 13, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30079471/brain-mri-features-of-csf-human-immunodeficiency-virus-escape
#11
Jared Narvid, Andrew Callen, Jason Talbott, Alina Uzelac, Sara M Dupont, Felicia Chow, Richard W Price, Bhavya Rehani
BACKGROUND AND PURPOSE: HIV infection of the central nervous system (CNS) is a nearly universal feature of untreated systemic HIV infection. While combination antiretroviral therapy (ART) that suppresses systemic infection usually suppresses CNS (CNS) HIV infection, exceptions have been reported with discordance between CSF and blood HIV RNA concentrations such that CSF demonstrates higher HIV concentrations than blood, referred to as CSF HIV escape. Rarely, CSF HIV escape presents with neurological symptoms, called neurosymptomatic escape...
August 5, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30066449/differentiation-of-cerebellar-hemisphere-tumors-combining-apparent-diffusion-coefficient-histogram-analysis-and-structural-mri-features
#12
Seyedmehdi Payabvash, Tarik Tihan, Soonmee Cha
BACKGROUND AND PURPOSE: We aimed to develop a diagnostic algorithm for differentiation of cerebellar hemisphere tumors, combining Apparent Diffusion Coefficient (ADC) histogram analysis and structural imaging features. METHODS: Pretreatment MRI of patients with pathologically proven cerebellar hemisphere neoplasms were reviewed. Voxel-wise volumetric ADC histograms of tumor solid components were determined. Histogram variables, patients' age, and structural imaging features were applied to develop a differential diagnosis algorithm...
August 1, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30066349/contribution-of-quantitative-amygdalar-mr-flair-signal-analysis-for-lateralization-of-mesial-temporal-lobe-epilepsy
#13
Kourosh Jafari-Khouzani, Kost Elisevich, Vibhangini S Wasade, Hamid Soltanian-Zadeh
BACKGROUND AND PURPOSE: This study evaluates the contribution of an automated amygdalar fluid-attenuated inversion recovery (FLAIR) signal analysis for the lateralization of mesial temporal lobe epilepsy (mTLE). METHODS: Sixty-nine patients (27 M, 42 F) who had undergone surgery and achieved an Engel class Ia postoperative outcome were identified as a pure cohort of mTLE cases. Forty-six nonepileptic subjects comprised the control group. The amygdala was segmented in T1-weighted images using an atlas-based segmentation...
August 1, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30066477/toxic-metabolic-neurologic-disorders-in-children-a-neuroimaging-review
#14
REVIEW
Marinos Kontzialis, Thierry A G M Huisman
There are multiple causes of neurotoxicity in children including medications, extrinsic toxins and insults, illicit drugs, built up of toxic metabolites due to genetic or acquired disorders, and metabolic abnormalities. The review is centered on causes of neurotoxicity affecting the pediatric brain and producing typical and easily recognized imaging manifestations. Early identification of common and less common imaging findings may point toward the correct direction, and may facilitate early diagnosis and institution of appropriate treatment to reverse or at least limit the injury to the developing brain...
July 31, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30039613/multiple-sclerosis-fatigue-a-longitudinal-structural-mri-and-diffusion-tensor-imaging-study
#15
K Yarraguntla, N Seraji-Bozorgzad, S Lichtman-Mikol, S Razmjou, F Bao, S Sriwastava, C Santiago-Martinez, O Khan, E Bernitsas
BACKGROUND AND PURPOSE: Previous cross-sectional studies have reported the involvement of thalamus, pallidum, superior cerebellar peduncle, temporal cortex, and fronto-parietal white matter in multiple sclerosis (MS)-related fatigue. However, the longitudinal imaging correlates of fatigue severity variation in MS remain unclear. METHODS: Structural and diffusion tensor imaging (DTI) data were collected from 43 relapsing remitting MS (RRMS) patients with fatigue (Fatigue Severity Scale [FSS] range: 1-7)...
July 23, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30028554/fronto-insular-connectivity-during-pain-distraction-is-impaired-in-patients-with-somatoform-pain
#16
Anne Stankewitz, Christian Sorg, Alexander von Kalckreuth, Enrico Schulz, Michael Valet, Susanne Neufang, Claus Zimmer, Peter Henningsen, Harald Gündel, Afra M Wohlschläger, Thomas R Tölle
BACKGROUND AND PURPOSE: Somatoform pain disorder is characterized by chronic pain and various psychological symptoms including increased attention to mental and physical processes. Given that the medial prefrontal cortex (mPFC) of the default mode network (DMN) and the anterior insula of the salience network are critically involved in intrinsic and attentional processes, we investigated the involvement of these networks during the distraction from physical pain in somatoform pain patients...
July 20, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/30010229/the-frequency-of-substantial-salvageable-penumbra-in-thrombectomy-ineligible-patients-with-acute-stroke
#17
Mersedeh Bahr Hosseini, Graham Woolf, Latisha K Sharma, Jason D Hinman, Neal M Rao, Bryan Yoo, Reza Jahan, Sidney Starkman, May Nour, Radoslav Raychev, David S Liebeskind, Jeffrey L Saver
BACKGROUND AND PURPOSE: Endovascular therapy (ET) has become the standard of care for selected patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, many LVO or medium vessel occlusion (MVO) patients are ineligible for ET, including some who harbor salvageable tissues. To develop complementary therapies for these patients, it is important to delineate their prevalence, clinical features, and outcomes. METHODS: In a prospectively maintained database, we reviewed consecutive AIS patients between December 2015 and September 2016...
July 16, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29999204/use-of-the-nesma-filter-to-improve-myelin-water-fraction-mapping-with-brain-mri
#18
Mustapha Bouhrara, David A Reiter, Michael C Maring, Jean-Marie Bonny, Richard G Spencer
BACKGROUND AND PURPOSE: Myelin water fraction (MWF) mapping permits direct visualization of myelination patterns in the developing brain and in pathology. MWF is conventionally measured through multiexponential T2 analysis which is very sensitive to noise, leading to inaccuracies in derived MWF estimates. Although noise reduction filters may be applied during postprocessing, conventional filtering can introduce bias and obscure small structures and edges. Advanced nonblurring filters, while effective, exhibit a high level of complexity and the requirement for supervised implementation for optimal performance...
July 12, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29992676/real-time-cerebral-hemodynamic-response-to-tactile-somatosensory-stimulation
#19
Benjamin Hage, Emily Way, Steven M Barlow, Gregory R Bashford
BACKGROUND AND PURPOSE: Recent studies in rodents suggest that somatosensory stimulation could provide neuroprotection during ischemic stroke by inducing plasticity in the cortex-vasculature relationship. While functional magnetic resonance imaging (fMRI) has shown that somatosensory stimulation increases cerebral blood flow (CBF) over several seconds, subsecond changes in CBF in the basal cerebral arteries have rarely been studied due to temporal resolution limitations. This study characterized hemodynamic changes in the middle cerebral arteries (MCAs) during somatosensory stimulation with high temporal resolution (100 samples/s) using functional transcranial Doppler ultrasound (fTCD)...
July 10, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29989259/mdp-spect-versus-hybrid-mdp-spect-ct-in-the-evaluation-of-suspected-pars-interarticularis-fracture-in-young-athletes
#20
Santhosh Gaddikeri, Manuela Matesan, Jacqueline Alvarez, Daniel S Hippe, Hubert J Vesselle
BACKGROUND AND PURPOSE: To assess benefits of hybrid (single photon emission computerized tomography [SPECT]/computed tomography [CT]) imaging over SPECT imaging only in the management of young athletes with low back pain (LBP) due to suspected pars interarticularis fracture. METHODS: Retrospectively reviewed medical records of 163 consecutive patients who had radionuclide SPECT imaging for evaluation of LBP between January 1, 2010 and December 30, 2015. All enrolled patients were divided into two groups (group 1: patients with radionuclide SPECT imaging only and group 2: patients with radionuclide hybrid imaging)...
July 10, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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