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Cleft Palate-craniofacial Journal

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https://www.readbyqxmd.com/read/27802067/an-intercenter-comparison-of-dental-arch-relationships-and-craniofacial-form-including-a-center-using-nasoalveolar-molding
#1
Supakit Peanchitlertkajorn, Ana Mercado, John Daskalogiannakis, Ronald Hathaway, Kathleen Russell, Gunvor Semb, William Shaw, Manish Lamichane, Jennifer Fessler, Ross E Long
OBJECTIVE: To compare dental arch relationship and craniofacial morphology of patients with CUCLP in pre-adolescence from five cleft centers including a center using NAM. DESIGN: Retrospective cohort study. SETTING: Five cleft centers in North America. PATIENTS: One hundred eighty-two subjects with repaired CUCLP from the five cleft centers participated in the craniofacial form study. One hundred forty-eight subjects from four of the five centers participated in the dental arch relationship study...
July 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27505182/rescue-of-premature-coronal-suture-fusion-with-tgf-%C3%AE-2-neutralizing-antibody-in-rabbits-with-delayed-onset-synostosis
#2
Mark P Mooney, Jocelyn M Shand, Anne Burrows, Timothy D Smith, John F Caccamese, Gregory M Cooper, James J Cray, James Gilbert, Bernard J Costello, Joseph E Losee, Amr M Moursi, Michael I Siegel
OBJECTIVES: An overexpression of Tgf-β2 leads to calvarial hyperostosis and suture fusion in individuals with craniosynostosis. Inhibition of Tgf-β2 may help rescue fusing sutures and restore normal growth. The present study was designed to test this hypothesis. DESIGN: Twenty-eight New Zealand White rabbits with delayed-onset coronal synostosis had radiopaque markers placed on either side of the coronal sutures at 10 days of age. The rabbits were randomly assigned to: (1) sham control rabbits (n = 10), (2) rabbits with control IgG (100 μg/suture) delivered in a collagen vehicle (n = 9), and (3) rabbits with Tgf-β2 neutralizing antibody (100 μg/suture) delivered in a collagen vehicle (n = 9)...
July 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27441703/letter-to-the-editor-regarding-airway-management-in-pierre-robin-sequence-patterns-of-practice
#3
E T van Lierop, S A Al-Ani, R Vidyadharan, R Slator
No abstract text is available yet for this article.
July 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29665342/age-at-time-of-craniosynostosis-repair-predicts-increased-complication-rate
#4
William J Bruce, Victor Chang, Cara J Joyce, Adrienne N Cobb, Uma I Maduekwe, Parit A Patel
OBJECTIVE: This study uses administrative data to assess the optimal timing for surgical repair of craniosynostosis and to identify factors associated with risk of perioperative complications. DESIGN: Statistical analysis of the Healthcare Cost and Utilization Project Kids' Inpatient Database (2006, 2009, 2012). SETTING: KID-participating hospitals in 44 states. PATIENTS: Children 0 to 3 years of age with ICD-9 codes for surgical correction of craniosynostosis (756 and 0124, 0125, 0201, 0203, 0204, or 0206)...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29665341/the-median-mandibular-symphysis-tessier-30-cleft-3d-imaging-analysis-and-review-of-the-literature
#5
Siddharth Mahajan, Pravin K Patel, Yao Duan, Neil Warshawsky
Atypical craniofacial clefts of the upper facial region have been well documented; however, the mandibular clefts remain rare and reported as isolated case reports. We report a case of a median mandibular cleft within the context of a Tessier 0-14 axis that we have followed over a 5-year period without surgical/orthodontic intervention. The mandibular symphysis cleft remained open without evidence of the fusion, in contrast to ossification of the metopic dysraphism. Within this context, we present a review of the median mandibular cleft cases from 1819 to 2015...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29589980/le-fort-iii-distraction-with-internal-vs-external-distractors-a-cephalometric-analysis
#6
Kevin J Robertson, Bernardino M Mendez, William J Bruce, Brendan D McDonnell, Michael V Chiodo, Parit A Patel
OBJECTIVE: This study compares the change in midface position following Le Fort III advancement using either rigid external distraction (group 1) or internal distraction (group 2). We hypothesized that, with reference to right-facing cephalometry, internal distraction would result in increased clockwise rotation and inferior displacement of the midface. DESIGN: Le Fort III osteotomies and standardized distraction protocols were performed on 10 cadaveric specimens per group...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29570384/the-effects-of-age-at-cleft-palate-repair-on-middle-ear-function-and-hearing-level
#7
Qun Lou, Hongping Zhu, Yi Luo, Zhibo Zhou, Lian Ma, Xiaoran Ma, Yuan Fu
OBJECTIVE: To investigate the age effects of cleft palate repair on middle ear function and hearing level in patients who underwent cleft palate repair at different ages by audiologic examination. METHODS: Medical histories were gathered in detail, and audiologic tests (ie, tympanometry and pure tone hearing threshold) were conducted in 126 patients after palatoplasty. The patients were divided into the following 4 groups according to their ages when they underwent cleft palate repair: group I (0-3 years, 73 patients), group II (4-7 years, 29 patients), group III (8-11 years, 16 patients), and group IV (12 years and older, 8 patients)...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29518343/dentoalveolar-cleft-treatment-outcome-using-modified-huddart-bodenham-index-and-regression-analysis-of-associated-factors
#8
Anas Imran Arshad, Mohammad Khursheed Alam, Mohammad Fadhli Khamis
OBJECTIVES: The aim of this study is to assess the treatment outcome of complete unilateral cleft lip and palate (CUCLP) patients using modified Huddart/Bodenham scoring system (MHB). To determine whether there is an association of congenital and postnatal factors with the treatment outcome. DESIGN: Retrospective observational study. SETTING: Two regional cleft-referral centers. MAIN OUTCOME MEASURES: In the current study, 101 pairs of dental models of non-syndromic CUCLP patients were retrieved from hospital archives...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29490148/double-opposing-z-plasty-for-secondary-surgical-management-of-velopharyngeal-insufficiency-following-primary-furlow-palatoplasty
#9
Arun K Gosain, Harvey Chim, Walter M Sweeney
OBJECTIVE: The present study investigates the efficacy of performing a "palate rerepair" utilizing a double-opposing z-palatoplasty (DOZ) following primary Furlow palatoplasty. DESIGN: Retrospective study. SETTING: Tertiary referral academic center for craniofacial surgery. PATIENTS: 15 consecutive patients who presented with velopharyngeal insufficiency (VPI) after primary Furlow palatoplasty. MAIN OUTCOME MEASURES: All subjects were evaluated using the perceptual speech assessment (PSA) scale...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29489415/novel-grem1-variations-in-sub-saharan-african-patients-with-cleft-lip-and-or-cleft-palate
#10
Lord Jephthah Joojo Gowans, Ganiyu Oseni, Peter A Mossey, Wasiu Lanre Adeyemo, Mekonen A Eshete, Tamara D Busch, Peter Donkor, Solomon Obiri-Yeboah, Gyikua Plange-Rhule, Alexander A Oti, Arwa Owais, Peter B Olaitan, Babatunde S Aregbesola, Fadekemi O Oginni, Seidu A Bello, Rosemary Audu, Chika Onwuamah, Pius Agbenorku, Mobolanle O Ogunlewe, Lukman O Abdur-Rahman, Mary L Marazita, A A Adeyemo, Jeffrey C Murray, Azeez Butali
OBJECTIVE: Cleft lip and/or cleft palate (CL/P) are congenital anomalies of the face and have multifactorial etiology, with both environmental and genetic risk factors playing crucial roles. Though at least 40 loci have attained genomewide significant association with nonsyndromic CL/P, these loci largely reside in noncoding regions of the human genome, and subsequent resequencing studies of neighboring candidate genes have revealed only a limited number of etiologic coding variants. The present study was conducted to identify etiologic coding variants in GREM1, a locus that has been shown to be largely associated with cleft of both lip and soft palate...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29489414/morphologic-evaluation-for-safe-le-fort-i-osteotomy-in-cleft-lip-and-palate
#11
Miki Watanabe, Akira Watanabe, Nobuo Takano, Chikara Saito, Takahiko Shibahara
OBJECTIVE: The present study aimed to determine the structure and morphology of the maxilla in patients with cleft lip and palate to ensure safe Le Fort I osteotomy. PATIENTS: A total of 34 sides of 17 patients with unilateral cleft lip and palate (nonsyndromic cases) were included in this study. The control group included 10 sides of 5 patients who exhibited skeletal mandibular protrusion without malformation. METHODS: Finite element analysis was performed to examine the distribution of occlusal force over the maxilla, and continuous 3-dimensional measurement was performed at the sites of stress concentration...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29489413/anomalous-extratemporal-facial-nerve-in-oculoauriculovertebral-spectrum
#12
Linden K Head, Lisa Xuan, Kirsty U Boyd, Daniel A Peters
Facial nerve dysfunction is common in oculoauriculovertebral spectrum (OAVS). However, the course of the nerve has rarely been described. A 23-year-old woman with OAVS underwent excision of microtic ear remnants in preparation for an osseointegrated prosthesis and suffered iatrogenic transection of the facial nerve-the pes anserinus was within the subcutaneous tissue 15 mm posterior and 15 mm cephalad to the external acoustic meatus. The patient underwent primary nerve repair and regained nearly complete preoperative function...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29489401/cervical-spine-injury-from-unrecognized-craniocervical-instability-in-severe-pierre-robin-sequence-associated-with-skeletal-dysplasia
#13
Xiao Zhu, Kelly N Evans, Areeg El-Gharbawy, Jonathan Y Lee, Jack E Brooker, Noel Jabbour, Elizabeth C Tyler-Kabara, Suneeta Madan-Khertarpal, Joseph E Losee, Jesse A Goldstein
Pierre Robin Sequence (PRS) can be associated with skeletal dysplasias, presenting with craniocervical instability and devastating spinal injury if unrecognized. The authors present the case of an infant with PRS and a type II collagenopathy who underwent multiple airway-securing procedures requiring spinal manipulation before craniocervical instability was identified. This resulted in severe cervical cord compression due to odontoid fracture and occipitoatlantoaxial instability. This case highlights the importance of early cervical spine imaging and cautious manipulation in infants with PRS and suspected skeletal dysplasia...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29461877/active-presurgical-infant-orthopedics-for-unilateral-cleft-lip-and-palate-intercenter-outcome-comparison-of-latham-modified-mcneil-and-nasoalveolar-molding
#14
Michelle Kornbluth, Richard E Campbell, John Daskalogiannakis, Elizabeth J Ross, Patricia H Glick, Kathleen A Russell, Jean-Charles Doucet, Ronald R Hathaway, Ross E Long, Thomas J Sitzman
OBJECTIVE: To compare dental arch relationship, craniofacial form, and nasolabial aesthetic outcomes among cleft centers using distinct methods of presurgical infant orthopedics (PSIO). DESIGN: Retrospective cohort study. SETTING: Four cleft centers in North America. PATIENTS: One hundred ninety-one children with repaired complete unilateral cleft lip and palate (CUCLP). MAIN OUTCOME MEASURES: Dental arch relationship was assessed using the GOSLON Yardstick...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29461876/voice-quality-in-adults-treated-for-unilateral-cleft-lip-and-palate-long-term-follow-up-after-1-or-2-stage-palate-repair
#15
Staffan Morén, Per Åke Lindestad, Mats Holmström, Maria Mani
OBJECTIVES: The aim of the current study was to assess voice quality among adults treated for unilateral cleft lip and palate (UCLP), after 1- or 2-stage palate closure, and compare it to a noncleft control group. STUDY DESIGN: Cross-sectional study in UCLP patients with long-term follow-up and noncleft controls. PARTICIPANTS: UCLP patients born 1960-1987, treated at Uppsala University Hospital, Sweden, were examined (n = 73) at a mean of 35 years after primary surgery...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446988/diagnosing-tongue-base-obstruction-in-pierre-robin-sequence-infants-sleep-vs-awake-endoscopy
#16
Jake J Lee, Matthew D Ford, Allison B Tobey, Noel Jabbour
OBJECTIVE: To investigate whether awake endoscopy can diagnose base-of-tongue obstruction as reliably as sleep endoscopy in infants with Pierre Robin sequence (PRS). DESIGN: The study was retrospective with the clinicians blinded to patient identity. Endoscopy findings were assessed and measured by the performing pediatric otolaryngologist. SETTING: Tertiary care children's hospital. PATIENTS: All infants with PRS managed between January 2005 and July 2015 were included...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446987/dexmedetomidine-decreases-postoperative-pain-and-narcotic-use-in-children-undergoing-alveolar-bone-graft-surgery
#17
Mariela M Lopez, Derrick Zech, Judith L Linton, Steven J Blackwell
OBJECTIVE: Dexmedetomidine is a parenteral agent that combines the benefits of cooperative sedation, anxiolysis, and analgesia without the risks of respiratory depression. Off-label use has been reported in children. We have introduced dexmedetomidine for use in patients having undergone alveolar bone graft (ABG). The objective is to demonstrate the value and safety of postoperative dexmedetomidine infusion in a non-ICU setting following ABG. DESIGN: A retrospective review was performed on patients who underwent ABG by the senior author...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29446986/an-intercenter-comparison-of-nasolabial-appearance-including-a-center-using-nasoalveolar-molding
#18
Supakit Peanchitlertkajorn, Ana Mercado, John Daskalogiannakis, Ronald Hathaway, Kathleen Russell, Gunvor Semb, William Shaw, Manish Lamichane, Marilyn Cohen, Ross E Long
OBJECTIVE: To compare nasolabial appearance outcomes of patients with complete unilateral cleft lip and palate (CUCLP) in preadolescence from 4 cleft centers including a center using nasoalveolar molding (NAM) and primary nasal reconstruction. DESIGN: Retrospective cohort study. SETTING: Four cleft centers in North America. PATIENTS: 135 subjects with repaired CUCLP. METHODS: Frontal and profile facial pictures were assessed using the Asher-McDade rating scale...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29377723/facial-expressiveness-in-infants-with-and-without-craniofacial-microsomia-preliminary-findings
#19
Zakia Hammal, Jeffrey F Cohn, Erin R Wallace, Carrie L Heike, Craig B Birgfeld, Harriet Oster, Matthew L Speltz
OBJECTIVE: To compare facial expressiveness (FE) of infants with and without craniofacial macrosomia (cases and controls, respectively) and to compare phenotypic variation among cases in relation to FE. DESIGN: Positive and negative affect was elicited in response to standardized emotion inductions, video recorded, and manually coded from video using the Facial Action Coding System for Infants and Young Children. SETTING: Five craniofacial centers: Children's Hospital of Los Angeles, Children's Hospital of Philadelphia, Seattle Children's Hospital, University of Illinois-Chicago, and University of North Carolina-Chapel Hill...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29370530/head-first-not-feet-first-freeman-sheldon-syndrome-as-primarily-a-craniofacial-condition
#20
Mikaela I Poling, Craig R Dufresne
The historical and clinical basis for classification of Freeman-Sheldon syndrome as a craniofacial syndrome and explanation of the rationale underlying this decision is provided. Correctly classifying the condition will avoid confusion and may help to clarify the vernacular employed and eventually aid in improving diagnosis.
May 2018: Cleft Palate-craniofacial Journal
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