journal
MENU ▼
Read by QxMD icon Read
search

Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis

journal
https://www.readbyqxmd.com/read/30234546/sex-gender-and-venous-thromboembolism-do-we-care-enough
#1
Elena M Faioni, Maddalena L Zighetti, Nadia P Vozzo
: The role of sex and gender in determining clinical presentation, diagnostic approach and outcomes of venous thromboembolism is not fully and systematically addressed, except for hormone-related events in women. A lack of knowledge is also apparent regarding drug prescription patterns, physician bias, enrolment in clinical studies and analysis of sex-related confounders in preclinical and clinical studies. As was shown for cardiovascular disease, ignoring sex and gender in medicine can have important impact on outcomes, including mortality...
September 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30234545/thrombogenesis-and-thrombotic-disorders-based-on-two-path-unifying-theory-of-hemostasis-philosophical-physiological-and-phenotypical-interpretation
#2
Jae C Chang
: Hemostasis, endowed to human to protect lives, is a process of logical blood clotting system to prevent blood loss in vascular injury. However, the notion that deadly thrombosis occurs as a result of normal hemostasis in intravascular injury could encounter with conceptual skepticism because the term 'thrombosis' automatically conjures up as serious disease. According to 'two-path unifying theory', normal hemostasis is initiated only by vascular injury through activated unusually large von Willebrand factor (ULVWF) path and/or activated tissue factor (TF) path...
September 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30234544/reliability-of-the-portable-coagulometer-qlabs-to-accurately-measure-the-activated-thromboplastin-time-and-international-normalized-ratio-a-prospective-study-in-critically-ill-patients
#3
Manuel Casado-Méndez, Victoria Arellano-Orden, Manuel Muñoz-Gómez, Francisco J Rodríguez-Martorell, Aurelio Cayuela, Álvaro Pastor de Las Heras, Ana Díaz Martín, Ignacio Pérez Torres, Santiago R Leal-Noval
: The current prospective study was aimed at investigating whether a portable coagulometer (qLabs) can be used to reliably monitor activated thromboplastin time (aPTT) and international normalized ratio (INR) in critically ill patients, as compared with standard central laboratory measurement. Both precision and accuracy of INR and aPTT measured by qLabs were assessed in this observational study by finger prick group (N = 30 patients) and blood droplet group from central venous catheter drawn (N = 60)...
September 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30234543/thromboelastography-in-the-management-of-snakebite-induced-coagulopathy-a-case-series-and-literature-review
#4
Patrick Leffers, Jason Ferreira, Dawn Sollee, Jay Schauben
: North American crotaline envenomations are a significant source of morbidity annually. Envenomation is marked by a constellation of effects that can include severe tissue damage, systemic effects such as anaphylaxis, and coagulopathy with bleeding. Traditionally, static plasma-derived tests such as protime and PTT are used to assess coagulation status. However, other tests are available that provide a whole blood assessment of all portions of coagulation including initiation, propagation, and clot maintenance...
September 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30113321/optimizing-outcome-measurement-with-murine-ferric-chloride-induced-thrombosis
#5
Bryn Kastetter, Amanda B Matrai, Brian C Cooley
: The murine FeCl3 model is a widely used model for studying arterial thrombosis, yet provides limited information from each mouse, often only a single time point for the onset of occlusion (defined as the time to occlusion; TTO). To optimize data from the murine ferric chloride model of thrombosis. FeCl3 injury was induced in the carotid arteries of wild-type and Factor IX (FIX) knockout mice, with infusion of recombinant FIX (rFIX) to normalize FIX deficiency at various times around FeCl3 injury. The TTO was recorded as a percentage of baseline flow as occlusion continued to zero flow, with identification of reflow events...
August 14, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30063477/hemostasis-based-on-a-novel-two-path-unifying-theory-and-classification-of-hemostatic-disorders
#6
Jae C Chang
: Hemostasis is the most important protective mechanism for human survival following harmful vascular damage caused by internal disease or external injury. Physiological mechanism of hemostasis is partially understood. Hemostasis can be initiated by either intravascular injury or external bodily injury involving two different levels of damage [i.e., limited to the endothelium or combined with extravascular tissue (EVT)]. In intravascular injury, traumatic damage limited to local endothelium typically is of no consequence, but disease-induced endothelial damage associated with systemic endothelial injury seen in sepsis and other critical illnesses could cause generalized 'endotheliopathy'...
July 30, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30045050/management-of-dabigatran-after-overdosage-two-case-reports-and-suggestions-for-monitoring
#7
Paul Billoir, Christophe Girault, Virginie Barbay, Deborah Boyer, Steven Grangé, Marielle Fresel, Marie Hélène Chrétien, Véronique Le Cam Duchez
: Bleeding is the main complication of anticoagulant treatments as dabigatran etexilate. In patients with atrial fibrillation, dabigatran, at certain doses, has been associated with similar rates of stroke and embolism, and a lower rate of major hemorrhage compared to warfarin. Before the recent possibility of reversing the anticoagulant effect of dabigatran with idarucizumab, prothrombin complex concentrate (PCC) was the main available treatment in cases of severe bleeding or emergency surgery [3]. We describe two different cases with very high overdosage in which PCC or idarucizumab was used to reverse the effect of dabigatran etexilate...
July 23, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30036281/a-novel-type-2n-vwf-gene-mutation-a-case-report
#8
Matthew S Evans, M Elaine Eyster
: Men and boys who present with bleeding associated with low factor VIII levels and normal von Willebrand studies are assumed to have hemophilia A until proven otherwise. However, routinely available coagulation assays cannot easily distinguish mild hemophilia A from the 2N variant of von Willebrand disease. We present a case that highlights the difficulties of recognizing this diagnosis, the role of genetic testing, and the identification of a 2N variant that has not been previously described.
July 19, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30036280/effect-of-abo-blood-group-on-haemostatic-parameters-in-severe-haemophilia-a-patients-performing-acute-moderate-intensity-exercise
#9
Clémence Merlen, Nichan Zourikian, Arnaud Bonnefoy, Evemie Dubé, Catherine Thibeault, Jean St-Louis, Georges-Etienne Rivard
: The primary objective was to assess the effect of ABO blood group on von Willebrand factor (VWF) rise induced by four bouts of moderate-intensity physical activity, on pharmacokinetics of a B-domain-deleted recombinant FVIII (BDD-rFVIII), and haemostatic parameters in severe haemophilia A patients with a null mutation. The secondary objective was to compare the response to exercise according to infused product type in a subgroup of patients who previously participated to the same exercise protocol, while treated with a full length recombinant FVIII (FL-rFVIII)...
July 19, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30036279/genotyping-of-five-pakistani-patients-with-severe-inherited-factor-x-deficiency-identification-of-two-novel-mutations
#10
Munira Borhany, Delphine Buthiau, Florence Rousseau, Olivier Guillot, Fatima Naveena, Madiha Abid, Tahir Shamsi, Muriel Giansily-Blaizot
: Congenital factor X deficiency is a rare coagulation defect characterized by variable bleeding tendency. The aim of the study was to give a first insight of F10 gene mutations in Pakistani probands. Direct sequencing and/or next-generation sequencing was performed on the coding regions, boundaries and 5' and 3' untranslated regions of the F10 gene in five severe factor X-deficient patients from Pakistan. All patients were born from consanguineous marriages and displayed FX:C levels below 2%. Sequencing revealed five different substitutions, including three previously reported p...
July 19, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30024426/impact-of-obesity-on-heparin-induced-thrombocytopenia-in-cardiac-surgery-patients
#11
Anna Vittoria Mattioli, Antonio Manenti, Alberto Farinetti
No abstract text is available yet for this article.
July 17, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29995655/l-carnitine-as-an-additive-in-tyrode-s-buffer-during-platelet-storage
#12
Manasa Mithun, Vani Rajashekaraiah
: Platelets are stored at 22-24°C for 5 days, with gentle agitation. Platelet storage lesion decreases efficacy and safety of stored platelets. L-Carnitine is a nonessential amino acid. Its interference with arachidonic acid metabolism affects platelet functions and oxidative stress. Hence, our study focuses on the use of L-carnitine in storage solution and investigates its influence on platelet functions and oxidative stress. Platelets isolated from 4-month-old male Wistar rats were stored with and without L-carnitine (10, 50 and 100 mmol/l) at 22°C for 12 days...
July 10, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30113416/validation-of-the-sta-liatest-ddi-assay-for-exclusion-of-proximal-deep-vein-thrombosis-according-to-the-latest-clinical-and-laboratory-standards-institute-food-and-drug-administration-guideline-results-of-a-multicenter-management-study
#13
Carlos Aguilar, Michelangelo Sartori, Armando D'Angelo, Christopher Kabrhel, James Groce, Emmanuel de Maistre, Suman M Wasan, Jeannine Kassis, John Lazarchick, Colin Kaide, Pascual Marco Vera, Jeffrey Kline, D Mark Courtney, Andrew Rubin, Melhem Sharafuddin, Gilles Pernod
: Recommended strategy for venous thromboembolism (VTE) diagnosis includes the use of sensitive D-dimer (DDi) assays along with pretest probability (PTP) assessment. The Clinical and Laboratory Standards Institute (CLSI) recently issued a guideline (US FDA endorsed) on DDi in VTE exclusion. Such guideline specifies the ideal D-dimer assay characteristics and target population. Demonstrate STA-LiatestD-Di performance combined with a PTP score for proximal deep vein thrombosis (pDVT) exclusion in a CLSI compliant study...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30036278/neonates-born-to-mothers-with-immune-thrombocytopenia-11-years-experience-of-a-single-academic-center
#14
Neslihan Karakurt, İlker Uslu, Canan Albayrak, Leman Tomak, Elif Ozyazici, Davut Albayrak, Canan Aygun
: A major problem associated with immune thrombocytopenic purpura (ITP) in pregnancy is neonatal thrombocytopenia. We analyzed newborns born to mothers with ITP and examined predictive factors for thrombocytopenia. This retrospective study was performed in a single academic center from January 2007 to January 2018. Pregnant women with ITP and their babies are included. All neonates had a complete blood count and cranial ultrasound (USG) performed. Twenty seven neonates of 22 mothers were evaluated. A total of 23 (85%) of neonates were thrombocytopenic (<150 × 10/l) and in 20 (74%) platelet count was below 50 × 10/l...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30020119/evaluation-of-early-musculoskeletal-disease-in-patients-with-haemophilia-results-from-an-expert-consensus
#15
Axel Seuser, Claudia Djambas Khayat, Claude Negrier, Adly Sabbour, Lily Heijnen
: Early joint damage in patients with haemarthrosis often escapes diagnosis because of insufficient investigation of biomechanical changes. Arthropathy in haemophilia requires complex assessment with several tools. Considering the increased emphasis on an integrated approach to musculoskeletal (MSK) outcomes, re-evaluation of MSK assessment to address individual patient needs is warranted. To advise on the optimal use of current assessment tools and strategies for tailored MSK evaluation in patients with haemophilia...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/30015646/comparison-of-a-new-criteria-for-sepsis-induced-coagulopathy-and-international-society-on-thrombosis-and-haemostasis-disseminated-intravascular-coagulation-score-in-critically-ill-patients-with-sepsis-3-0-a-retrospective-study
#16
Renyu Ding, Zhong Wang, Yuan Lin, Baoyan Liu, Zhidan Zhang, Xiaochun Ma
: Recently, new criteria for sepsis-induced coagulopathy (SIC) were developed, including the sequential organ failure assessment (SOFA) criteria. The objective of this study was to evaluate the new SIC criteria in patients diagnosed with sepsis 3.0. Data from patients diagnosed with sepsis 3.0 after ICU admission were retrospectively obtained from July 2013 to June 2014. Relevant demographic, clinical, and laboratory parameters were noted. This study included 252 patients. The International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC), modified ISTH-DIC, and SIC scores were higher among nonsurvivors (P < 0...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29995659/venous-thromboembolism-risk-associated-with-abo-f11-and-fgg-loci
#17
Licínio Manco, Catarina Silva, Teresa Fidalgo, Patrícia Martinho, Ana B Sarmento, M Letícia Ribeiro
: The current study aims to evaluate, for the first time in the Portuguese population, the association with venous thromboembolism (VTE) of five well known and replicated VTE-associated single nucleotide polymorphisms (SNPs) in genes ABO, F11 and FGG. A population sample of 96 cases of VTE, without strong or moderate inherited or noninherited predisposing factors, and 148 healthy controls were analyzed for variants in genes ABO (rs2519093; rs8176719), F11 (rs2036914; rs2289252) and FGG (rs2066865). SNPs were genotyped by real-time PCR with TaqMan probes or by PCR-restriction fragment length polymorphism...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29995658/ibrutinib-related-bleeding-pathogenesis-clinical-implications-and-management
#18
Carlos Aguilar
: Ibrutinib is the first drug of a new family of Bruton's tyrosine kinases (Btk)-inhibiting agents, which have proved to be useful for the treatment of several B-cell lymphoid malignancies. This drug is associated to an increased bleeding risk from initial clinical trials especially in association with warfarin. Although Btk plays an important role in platelet signalling, increased bleeding tendency in patients on ibrutinib is more complex than Btk inhibition alone and is because of several antiplatelet mechanisms, namely inhibition of Btk and Tec kinases, which play a key role in platelet activation downstream of the collagen GPVI and Glycoprotein Ib...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29995657/wdr-1-is-essential-for-f-actin-interaction-with-focal-adhesions-in-platelets
#19
Swapan K Dasgupta, Perumal Thiagarajan
: Wdr-1, an actin interacting protein, enhances cofilin's capacity to accelerate depolymerization of F-actin filaments. Wdr-1-deficient mice have impaired hemostasis due to defective inside-out integrin signaling in platelets. Here, we studied the role of Wdr-1 on outside-in signaling necessary for retraction of the clot and platelet spreading. Outside-in signaling was assessed by fibrin clot retraction assay and by adhesion and spreading of unstimulated platelets on fibrinogen substrate. The spatial distribution of actin, cofilin-1 and Wdr-1 were determined by immunofluorescence microscopy...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29995656/thromboelastographic-analysis-of-haemostasis-in-preeclamptic-and-normotensive-pregnant-women
#20
Erin K I Murray, Malia S Q Murphy, Graeme N Smith, Charles H Graham, Maha Othman
: Pregnancy is a state of heightened coagulation, exacerbated in pathological conditions such as preeclampsia. We evaluated the role of thromboelastography (TEG), compared with standard haemostasis tests, in identifying in haemostatic alterations in normotensive pregnancies and pregnancies complicated with preeclampsia. Standard haemostasis tests and TEG were performed on 28 normotensive women and 31 with preeclampsia at delivery, 6 weeks and 6 months postpartum. Results were compared between patient groups, and at different collection times...
September 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
journal
journal
30651
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"