journal
MENU ▼
Read by QxMD icon Read
search

Drugs & Aging

journal
https://www.readbyqxmd.com/read/27913982/pharmacological-management-of-allergic-rhinitis-in-the-elderly
#1
REVIEW
Andrzej Bozek
Recent studies suggest that allergic rhinitis is highly prevalent in the elderly population, but is underdiagnosed and undertreated. This review article briefly introduces allergic rhinitis in the elderly (epidemiology and pathophysiology) and identifies the main goals of treatment in these patients with respect to age-related physiological factors, comorbid conditions and polypharmacy. The primary focus of the article is a narrative review of the literature concerning the different types of treatment options in elderly patients aged 60+ years (pharmacological therapy and allergen-specific immunotherapy)...
December 3, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27913981/the-challenges-of-anaesthesia-and-pain-relief-in-hip-fracture-care
#2
Rachel Cowan, Jun Hao Lim, Terence Ong, Ashok Kumar, Opinder Sahota
The care of the older person with hip fracture is complicated by their comorbid condition, limited physiological reserve, cognitive impairment and frailty. Two aspects of hip fracture management that have received considerable attention are how best to manage the pain associated with it and the ideal mode of anaesthesia. Existing literature has reported on the suboptimal treatment of pain in this orthogeriatric cohort. With recent advancements in medical care, a number of options have emerged as alternatives to conservative systemic analgesia...
December 3, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27896799/a-comparison-of-sex-differences-in-psychotropic-medication-use-in-older-people-with-alzheimer-s-disease-in-the-us-and-finland
#3
Daniela C Moga, Heidi Taipale, Anna-Maija Tolppanen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Qishan Wu, Gregory A Jicha, Danijela Gnjidic
AIMS: Given the high prevalence of psychotropic medication use in people with dementia and the potential for different prescribing practices in men and women, our study aimed to investigate sex differences in psychotropic medication use in older adults with Alzheimer's disease (AD) living in the US and Finland. METHODS: We used data collected between 2005 and 2011 as part of the National Alzheimer's Coordinating Center (NACC) in the US, and Medication use and Alzheimer's disease (MEDALZ) cohorts in Finland...
November 28, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27878527/acknowledgement-to-referees
#4
(no author information available yet)
No abstract text is available yet for this article.
November 22, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27873152/a-comparison-of-pharmacokinetic-and-pharmacodynamic-properties-between-faster-acting-insulin-aspart-and-insulin-aspart-in-elderly-subjects-with-type-1-diabetes-mellitus
#5
Tim Heise, Ulrike Hövelmann, Eric Zijlstra, Kirstine Stender-Petersen, Jacob Bonde Jacobsen, Hanne Haahr
BACKGROUND: Due to population aging, an increasing number of elderly patients with diabetes use insulin. It is therefore important to investigate the characteristics of new insulins in this population. Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with faster absorption. This study investigated the pharmacological properties of faster aspart in elderly subjects with type 1 diabetes mellitus (T1DM). METHODS: In a randomised, double-blind, two-period crossover trial, 30 elderly (≥65 years) and 37 younger adults (18-35 years) with T1DM received single subcutaneous faster aspart or IAsp dosing (0...
November 21, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27838819/risk-factors-for-initiation-of-potentially-inappropriate-medications-in-community-dwelling-older-adults-with-and-without-alzheimer-s-disease
#6
Virva Hyttinen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Anna-Maija Tolppanen, Sirpa Hartikainen, Hannu Valtonen
BACKGROUND: Various criteria have been created to define potentially inappropriate medications (PIMs) to help improve the quality and safety of medicine use in older patients. Individuals with Alzheimer's disease (AD) may be at higher risk of adverse drug events associated with PIMs (such as falls). OBJECTIVE: Our objective was to determine the risk factors for PIM initiation in a nationwide cohort of community dwellers aged ≥65 years with and without AD. METHODS: The Finnish nationwide MEDALZ cohort includes all patients diagnosed with AD in 2005-2011 (n = 70,718) and two comparison individuals without AD (non-AD) matched for age, sex and region of residence for each person with AD...
November 12, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27830567/prevalence%C3%A2-of-and-resident-and-facility-characteristics-associated-with-antipsychotic-use-in-assisted-living-vs-long-term-care-facilities-a-cross-sectional-analysis-from-alberta-canada
#7
Kathryn J Stock, Joseph E Amuah, Kate L Lapane, David B Hogan, Colleen J Maxwell
BACKGROUND: Potentially inappropriate antipsychotic use in long-term care (LTC) facilities has been the focus of significant policy and clinical attention over the past 20 years. However, most initiatives aimed at reducing the use of these medications have overlooked assisted living (AL) settings. OBJECTIVE: We sought to compare the prevalence of antipsychotic use (including potentially inappropriate use) among older AL and LTC residents and to explore the resident and facility-level factors associated with use in these two populations...
November 9, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27830566/ace-inhibitors-and-sarcopenia-covering-all-the-bases
#8
LETTER
Jochen Springer, Stephan von Haehling
No abstract text is available yet for this article.
November 9, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27826798/contribution-of-pharmacogenetic-testing-to-modeled-medication-change-recommendations-in-a-long-term-care-population-with-polypharmacy
#9
Elaine A Sugarman, Ali Cullors, Joel Centeno, David Taylor
BACKGROUND: Among long-term care facility residents, polypharmacy is common, and often appropriate, given the need to treat multiple, complex, chronic conditions. Polypharmacy has, however, been associated with increased healthcare costs, adverse drug events, and drug interactions. The current study evaluates the potential medication cost savings of adding personalized pharmacogenetic information to traditional medication management strategies. METHODS: One hundred and twelve long-term care residents completed pharmacogenetic testing for targeted variants in the following genes: CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4/CYP3A5, HTR2A, HTR2C, SLC6A4, SLC6A2 COMT, OPRM1, SLCO1B1, VKORC1 and MTHFR...
November 8, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27812994/a-review-of-adverse-outcomes-associated-with-psychoactive-drug-use-in-nursing-home-residents-with-dementia
#10
REVIEW
Maryse Lapeyre-Mestre
Treatment guidelines generally recommend careful assessment and non-pharmacological treatment approaches for behavioural and psychological symptoms of dementia. However, the inappropriate use of psychoactive drugs in patients with dementia in nursing homes is still prevalent. The aim of this narrative review is to summarise and criticize the most recent data investigating the adverse outcomes related to psychoactive drug use, specifically antipsychotics, antidepressants and benzodiazepines, in patients with dementia living in nursing homes...
November 4, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27798767/practical-management-of-anaesthesia-in-the-elderly
#11
Camilla Strøm, Lars Simon Rasmussen, Jacob Steinmetz
The elderly population is rapidly growing and particularly diverse. Ageing leads to reduced organ function and a decline in physiologic reserve. Elderly patients are characterised by great inter-individual variability in physiological function with a high prevalence of chronic disease. In general, older patients have a higher risk of postoperative adverse outcomes, and frailty is a very important risk factor. This review article aims to provide a practical guide to anaesthetic management of the elderly surgical patient...
October 31, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27785734/development-and-validation-of-the-revised-patients-attitudes-towards-deprescribing-rpatd-questionnaire-versions-for-older-adults-and-caregivers
#12
Emily Reeve, Lee-Fay Low, Sepehr Shakib, Sarah N Hilmer
BACKGROUND: Knowledge of consumer (patient and caregiver) attitudes is essential for conducting medication optimization in practice. OBJECTIVES: The aim of this study was to develop and validate a questionnaire to capture older adults' and caregivers' beliefs and attitudes towards deprescribing. METHODS: The previously validated Patients' Attitudes Towards Deprescribing (PATD) questionnaire was expanded based on literature review, expert opinion and focus groups, and a caregivers' version was developed...
October 27, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27785733/the-efficacy-and-safety-of-the-fentanyl-iontophoretic-transdermal-system-ionsys-%C3%A2-in-the-geriatric-population-results-of-a-meta-analysis-of-phase%C3%A2-iii-and-iiib-trials
#13
Eugene R Viscusi, Li Ding, Loretta M Itri
BACKGROUND AND OBJECTIVES: Acute postoperative pain management in the geriatric patient can be challenging, including their response to medications. The purpose of this analysis was to evaluate whether the efficacy and safety profile of fentanyl iontophoretic transdermal system (ITS) (IONSYS(®)) was similar in geriatric (≥65 years) and non-geriatric (<65 years) patients. METHODS: Efficacy and safety data from three randomized, double-blind, placebo-controlled trials and four randomized, open-label, active-comparator trials were utilized for this analysis...
October 27, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27738964/the-challenges-of-treating-sciatica-pain-in-older-adults
#14
Manuela L Ferreira, Andrew McLachlan
Sciatica is a debilitating condition affecting approximately 25 % of the population. Typically, the patient will complain of lower limb pain that is more severe than pain in the lower back, usually accompanied by numbness and motor weakness. Most international guidelines recommend pharmacological management for the pain relief of sciatica, including paracetamol, non-steroidal anti-inflammatory drugs, opioid analgesics, anticonvulsants, and corticosteroids, among others. However, the evidence for most of these pharmacological options is scarce, and the majority of clinical trials exclude older patients...
October 13, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27738963/autoimmune-blistering-diseases-in-the-elderly-clinical-presentations-and-management
#15
Minhee Kim, Luca Borradori, Dédée F Murrell
Elderly patients are more susceptible to the development of autoimmune blistering disorders such as bullous pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and paraneoplastic pemphigus. This article focuses on the clinical aspects of the aforementioned autoimmune blistering diseases and highlights the important factors involved in treating elderly patients. It is essential for clinicians to offer individualized treatment plans for these patients to optimize outcomes, as elderly patients often have multiple co-morbidities, polypharmacy, and suboptimal socioeconomic status that can adversely influence adequate compliance...
October 13, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27734278/inappropriate-prescription-and-renal-function-among-older-patients-with-cognitive-impairment
#16
Eva Sönnerstam, Maria Sjölander, Maria Gustafsson
BACKGROUND: Older people are more sensitive to drugs and adverse drug reactions than younger people because of age-related physiological changes such as impaired renal function. As people with dementia are particularly vulnerable to the effects of drugs, it is especially important to evaluate the dosages of renally cleared medications in this group. OBJECTIVE: The aim of this study was to estimate the prevalence of impaired renal function and inappropriate prescriptions on the basis of renal function among older patients with dementia or cognitive impairment...
October 12, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27709466/evaluating-the-role-of-hormone-therapy-in-postmenopausal-women-with-alzheimer-s-disease
#17
Jelena Osmanovic-Barilar, Melita Salkovic-Petrisi
Hormone therapy (HT) is prescribed during or after menopausal transition to replace the decline in estrogen and progesterone levels. While some studies indicate that estrogen and progesterone depletion in postmenopausal women might carry a significant risk for developing sporadic Alzheimer's disease (sAD), which may be reduced by HT, recent clinical trials oppose this beneficial effect. This review points to possible reasons for these mixed data by considering the issues of both preclinical and clinical trials, in particular, the representativeness of animal models, timing of HT initiation, type of HT (different types of estrogen compounds, estrogen monotherapy vs...
October 6, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27681702/effects-of-renal-impairment-on-steady-state-plasma-concentrations-of-rivastigmine-a-population-pharmacokinetic-analysis-of-capsule-and-patch-formulations-in-patients-with-alzheimer-s-disease
#18
Gilbert Lefèvre, Francesca Callegari, Sandro Gsteiger, Yuan Xiong
INTRODUCTION: The glomerular filtration rate (GFR), a measure of renal function, decreases by approximately 10 mL/min every 10 years after the age of 40 years, which could lead to the accumulation of drugs and/or renal toxicity. Pharmacokinetic studies of drugs excreted both renally and non-renally are desirable in patients with impaired renal function, defined by parameters including estimated GFR (eGFR) and creatinine clearance (CLCR). OBJECTIVE: We describe here a population pharmacokinetic analysis of the possible effects of renal impairment on steady-state plasma concentrations of rivastigmine and its metabolite NAP226-90 after rivastigmine patch (5 cm(2) [4...
September 28, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27665105/angiotensin-converting-enzyme-inhibitors-and-parameters-of-sarcopenia-relation-to-muscle-mass-strength-and-function-data-from-the-berlin-aging-study-ii-base-ii
#19
Dominik Spira, Jeremy Walston, Nikolaus Buchmann, Jivko Nikolov, Ilja Demuth, Elisabeth Steinhagen-Thiessen, Rahel Eckardt, Kristina Norman
BACKGROUND: Pharmacological options for the treatment of sarcopenia currently do not exist. However, off-label treatment options of some established drugs have been suggested. OBJECTIVES: The aim of this study was to assess differences in various muscle and physical performance parameters in relation to the intake of angiotensin-converting enzyme (ACE) inhibitors in a cohort of community-dwelling older people. METHODS: Eight hundred and thirty-eight participants from the Berlin Aging Study-II (BASE-II) were included...
September 24, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27878526/intravenous-vancomycin-dosing-in-the-elderly-a-focus-on-clinical-issues-and-practical-application
#20
Katie E Barber, Allison M Bell, Kayla R Stover, Jamie L Wagner
The elderly population can be divided into three distinct age groups: 65-74 years (young-old), 75-84 years (middle-old), and 85+ years (old-old). Despite evidence of a shift in leading causes for mortality in the elderly from infectious diseases to chronic conditions, infections are still a serious cause of death in this population. These patients are at increased risk due to weakened immune systems, an increased prevalence of underlying comorbidities, and decreased physiologic reserves to fight infection. Additionally, elderly patients, especially adults in institutional settings, are at an increased risk of colonization and subsequent infection with methicillin-resistant Staphylococcus aureus at a rate that is five times higher than in younger individuals, causing an increase in empiric and definitive vancomycin use...
December 2016: Drugs & Aging
journal
journal
30642
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"