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Drugs & Aging

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https://www.readbyqxmd.com/read/28432600/potentially-inappropriate-antihypertensive-prescriptions-to-elderly-patients-results-of-a-prospective-observational-study
#1
Paola H Ponte Márquez, Olga H Torres, Anonio San-José, Xavier Vidal, Antonia Agustí, Francesc Formiga, Alfonso López-Soto, Nieves Ramírez-Duque, Antonio Fernández-Moyano, Juana Garcia-Moreno, Juan A Arroyo, Domingo Ruiz
INTRODUCTION: Previous studies of antihypertensive treatment of older patients have focused on blood pressure control, cardiovascular risk or adherence, whereas data on inappropriate antihypertensive prescriptions to older patients are scarce. OBJECTIVES: The aim of the study was to assess inappropriate antihypertensive prescriptions to older patients. METHODS: An observational, prospective multicentric study was conducted to assess potentially inappropriate prescription of antihypertensive drugs, in patients aged 75 years and older with arterial hypertension (HTN), in the month prior to hospital admission, using four instruments: Beers, Screening Tool of Older Person's Prescriptions (STOPP), Screening Tool to Alert Doctors to the Right Treatment (START) and Assessing Care of Vulnerable Elders 3 (ACOVE-3)...
April 21, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28425024/lesinurad-a-review-in-hyperuricaemia-of-gout
#2
Emma D Deeks
Lesinurad (Zurampic(®)) is an oral selective inhibitor of the URAT1 and OAT4 uric acid (UA) transporters of the kidney, via which it inhibits UA reabsorption and thus increases renal UA excretion and lowers serum UA (sUA) levels. Lesinurad 200 mg once daily is indicated for use in combination with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in adults with gout who have not achieved target sUA levels with an XOI alone. Approval was based on three 12-month phase 3 trials that evaluated lesinurad in combination with allopurinol in adults with gout inadequately responsive to allopurinol (CLEAR 1 and 2) and in combination with febuxostat in adults with tophaceous gout (CRYSTAL)...
April 19, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28405945/the-comparative-risk-of-delirium-with-different-opioids-a-systematic-review
#3
REVIEW
Lieke M Swart, Vera van der Zanden, Petra E Spies, Sophia E de Rooij, Barbara C van Munster
OBJECTIVE: There is substantial evidence that the use of opioids increases the risk of adverse outcomes such as delirium, but whether this risk differs between the various opioids remains controversial. In this systematic review, we evaluate and discuss possible differences in the risk of delirium from the use of various types of opioids in older patients. METHODS: We performed a search in MEDLINE by combining search terms on delirium and opioids. A specific search filter for use in geriatric medicine was used...
April 12, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28405944/clinical-relevance-of-differences-in-glomerular-filtration-rate-estimations-in-frail-older-people-by-creatinine-vs-cystatin-c-based-formulae
#4
Anne Jacobs, Carolien Benraad, Jack Wetzels, Marcel Olde Rikkert, Cornelis Kramers
BACKGROUND: The risk of incorrect medication dosing is high in frail older people. Therefore, accurate assessment of the glomerular filtration rate is important. OBJECTIVE: The objective of this study was to compare the estimated glomerular filtration rate using creatinine- and cystatin C-based formulae, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, in frail older people. We hypothesized that frailty determines the difference between the creatinine- and cystatin C-based formulae...
April 12, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28391589/retraction-note-to-efficacy-of-antiresorptive-agents-for-preventing-fractures-in-japanese-patients-with-an-increased-fracture-risk-review-of-the-literature
#5
Jun Iwamoto, Yoshihiro Sato, Tsuyoshi Takeda, Hideo Matsumoto
No abstract text is available yet for this article.
April 8, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28365905/aflibercept-a-review-in-macular-oedema-secondary-to-branch-retinal-vein-occlusion
#6
Sheridan M Hoy
Aflibercept (Eylea(®)) is a fully human, recombinant fusion protein available in various countries worldwide, including those of the EU, as well as the USA, for intravitreal use in the treatment of macular oedema secondary to branch retinal vein occlusion (BRVO) in adults. Aflibercept acts as a soluble decoy receptor, binding with high affinity to vascular endothelial growth factor (VEGF)-A and placental growth factor (PIGF), preventing these angiogenic factors from binding to and activating their cognate receptors...
April 1, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28361278/cost-effectiveness-of-gastroprotection-with-proton-pump-inhibitors-in-older-low-dose-acetylsalicylic-acid-users-in-the-netherlands
#7
Sek Hung Chau, Reinier L Sluiter, Wietske Kievit, Michel Wensing, Martina Teichert, Jacqueline G Hugtenburg
PURPOSE: The present study aimed to assess the cost effectiveness of concomitant proton pump inhibitor (PPI) treatment in low-dose acetylsalicylic acid (LDASA) users at risk of upper gastrointestinal (UGI) adverse effects as compared with no PPI co-medication with attention to the age-dependent influence of PPI-induced adverse effects. METHODS: We used a Markov model to compare the strategy of PPI co-medication with no PPI co-medication in older LDASA users at risk of UGI adverse effects...
March 30, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28349415/pharmacotherapeutic-management-of-pancreatic-ductal-adenocarcinoma-current-and-emerging-concepts
#8
REVIEW
Dietrich A Ruess, Kivanc Görgülü, Sonja M Wörmann, Hana Algül
Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to become the second leading cause of cancer-related death by 2030. This review summarizes recent developments of oncological therapy in the palliative setting of metastatic pancreatic ductal adenocarcinoma. It further compiles novel targets and therapeutic approaches as well as promising treatment combinations, which are presently in preclinical evaluation, covering several aspects of the hallmarks of cancer...
March 27, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28349414/erratum-to-can-we-identify-patients-with-high-risk-of-osteoarthritis-progression-who-will-respond-to-treatment-a-focus-on-epidemiology-and-phenotype-of-osteoarthritis
#9
Olivier Bruyère, Cyrus Cooper, Nigel Arden, Jaime Branco, Maria Luisa Brandi, Gabriel Herrero-Beaumont, Francis Berenbaum, Elaine Dennison, Jean-Pierre Devogelaer, Marc Hochberg, John Kanis, Andrea Laslop, Tim McAlindon, Susanne Reiter, Pascal Richette, René Rizzoli, Jean-Yves Reginster
No abstract text is available yet for this article.
March 27, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28349413/erratum-to-diacerein-benefits-risks-and-place-in-the-management-of-osteoarthritis-an-opinion-based-report-from-the-esceo
#10
Karel Pavelka, Olivier Bruyère, Cyrus Cooper, John A Kanis, Burkhard F Leeb, Emmanuel Maheu, Johanne Martel-Pelletier, Jordi Monfort, Jean-Pierre Pelletier, René Rizzoli, Jean-Yves Reginster
No abstract text is available yet for this article.
March 27, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28349412/evaluating-outcomes-for-older-patients-with-parkinson-s-disease-or-dementia-with-lewy-bodies-who-have-been-hospitalised-for-hip-fracture-surgery-potential-impact-of-drug-administration
#11
Marie Enemark, Mette Midttun, Kristian Winge
INTRODUCTION: People with Parkinson's disease (PD) are at risk of falling and have an increased risk of complications and prolonged recovery during hospitalisation. OBJECTIVE: The aim of this study was to investigate the rate of complications and recovery related to a hip fracture in patients with PD. METHODS: All patients with PD or dementia with Lewy bodies (DLB) and a hip fracture who were admitted from January 2013 through June 2014 (18 months) to the Department of Orthopaedics, Copenhagen University Hospital, Herlev, Denmark were evaluated...
March 27, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28258537/use-of-an-e-learning-educational-module-to-better-equip-doctors-to-prescribe-for-older-patients-a-randomised-controlled-trial
#12
Shane Cullinan, Denis O'Mahony, Stephen Byrne
BACKGROUND: The older patient population is significantly different from the younger adult population with regards to dose selection for a wide variety of drugs. Recent investigation of prescribing attitudes indicates that doctors feel there is insufficient distinction made between the two cohorts during their undergraduate education, and that doctors do not receive enough training in geriatric pharmacotherapy. OBJECTIVES: The aim of this study was to determine if an online module, focused on geriatric pharmacotherapy, improves doctors' prescribing knowledge, as well as prescribing confidence, as applied to older patients...
March 4, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28258536/move-it-or-lose-it-is-it-reasonable-for-older-adults-with-osteoarthritis-to-continue-to-use-paracetamol-in-order-to-maintain-physical-activity
#13
REVIEW
Kayla Lee, Julie Cooke, Gabrielle Cooper, Alison Shield
Osteoarthritis is a common progressive disease in older adults, and those affected often have impaired physical function, co-existing disease states, and reduced quality of life. In patients with osteoarthritis, pain is reported as a primary cause of mobility limitation, and guidelines recommend a mix of pharmacologic and non-pharmacologic strategies for pain management. The benefits of exercise in the management of osteoarthritis are well established; however, pain appears to be the biggest barrier to patients engaging in, and adhering to, physical activity programs...
March 4, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28258535/routine-use-of-budesonide-formoterol-fixed-dose-combination-in-elderly-asthmatic-patients-practical-considerations
#14
Nicola Scichilone, Fulvio Braido, Federico Lavorini, Mark L Levy, Omar S Usmani
Asthma has been demonstrated to be as common in the elderly as in younger age groups. Although no specific recommendations exist to manage the disease differently in older individuals, functional features and clinical presentations may be affected by age per se, and by age-related conditions, such as comorbidities and polypharmacy. In this review article, we aimed to explore the efficacy and safety in elderly asthmatic patients of one of the most currently used inhaled treatments for asthma, that is, the fixed-dose combination of budesonide/formoterol...
March 4, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28247317/adverse-health-events-related-to-self-medication-practices-among-elderly-a-systematic-review
#15
REVIEW
Médéa Locquet, Germain Honvo, Véronique Rabenda, Thierry Van Hees, Jean Petermans, Jean-Yves Reginster, Olivier Bruyère
BACKGROUND: Older adults often resort to self-medication to relieve symptoms of their current illnesses; however, the risks of this practice are multiplied in old age. In particular, this age group is more vulnerable to adverse drug events because of the physiological changes that occur due to senescence. OBJECTIVE: The aim of the study was to obtain an overview of the adverse health events related to self-medication among subjects aged 60 years and over through a systematic review of the literature...
February 28, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28299634/prevalence-and-determinants-of-the-use-of-lipid-lowering-agents-in-a-population-of-older-hospitalized-patients-the-findings-from-the-reposi-registro-politerapie-societ%C3%A3-italiana-di-medicina-interna-study
#16
Marco Bertolotti, Carlotta Franchi, Marco B L Rocchi, Andrea Miceli, M Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi
BACKGROUND: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. AIM: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. METHODS: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28258538/trends-in-the-prescription-and-long-term-utilization-of-antidementia-drugs-among-patients-with-alzheimer-s-disease-in-spain-a-cohort-study-using-the-registry-of-dementias-of-girona
#17
Laia Calvó-Perxas, Oriol Turró-Garriga, Joan Vilalta-Franch, Manuela Lozano-Gallego, Rosa de Eugenio, Fabián Márquez, Olga Carmona, Jordi Gich, Anna Manzano, Marta Viñas, Anna Mª Roig, Josep Garre-Olmo
BACKGROUND: Acetylcholinesterase inhibitors (AChEIs) and the N-methyl D-aspartate-antagonist memantine are indicated for the symptomatic treatment of Alzheimer's disease (AD). OBJECTIVES: Our aims were to describe the baseline characteristics of patients with AD according to prescription of these treatments after the diagnostic work-up to describe long-term trends in the use of these medications and to identify baseline characteristics associated with the frequency of use of each treatment...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28247316/selecting-potential-pharmacological-interventions-in-sarcopenia
#18
Amanda J Kilsby, Avan A Sayer, Miles D Witham
Sarcopenia of age is prevalent and costly and proven pharmacological interventions are currently lacking. The pathophysiology of sarcopenia is incompletely understood but appears to involve multiple pathways, including inflammation, hormonal dysregulation, impaired regeneration, mitochondrial dysfunction and denervation. There are several ways in which we might select potential pharmacological interventions for testing in clinical trials. These include a 'bottom-up' approach using basic science to elucidate the molecular processes involved and identify potential targets from this knowledge-a strategy that has led to the development of myostatin inhibitors...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28224284/complementary-and-alternative-medicine-use-in-rheumatoid-arthritis-considerations-for-the-pharmacological-management-of-elderly-patients
#19
REVIEW
Sizheng Zhao, Fred Otieno, Asan Akpan, Robert J Moots
Complementary and alternative medicines (CAMs) are widely used by patients with rheumatoid arthritis (RA); however, a significant proportion of these patients do not inform their physicians. This has many potential implications in a group of predominantly elderly patients with altered pharmacokinetics, comorbidities and polypharmacy of potentially toxic drugs. CAM usage may affect compliance and pharmacokinetics of conventional therapy for RA and comorbidities; therefore, physicians should engage patients in dialogues regarding CAM usage...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28224283/health-service-use-costs-and-adverse-events-associated-with-potentially-inappropriate-medication-in-old-age-in-germany-retrospective-matched-cohort-study
#20
Dirk Heider, Herbert Matschinger, Andreas D Meid, Renate Quinzler, Jürgen-Bernhard Adler, Christian Günster, Walter E Haefeli, Hans-Helmut König
BACKGROUND: Drug-related problems are an important healthcare safety concern in the growing population of older people. Prescription of potentially inappropriate medication (PIM) is one aspect of this concern that is considered to increase the risk of adverse health outcomes. OBJECTIVE: The aim of the Health Economics of Potentially Inappropriate Medication (HEPIME) study was to analyze the association between the prescription of PIMs according to the German PRISCUS list and healthcare utilization, healthcare costs, and the occurrence of adverse events in old age...
April 2017: Drugs & Aging
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