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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/29040066/evaluation-of-oral-multi-herbal-preparation-of-dashmoolarishta-on-mice-model-of-osteoarthritis
#1
Yashashri C Shetty, Santosh Godbharle, Smita Brahma, Sweta Salgaonkar, Nirmala N Rege
BACKGROUND: Osteoarthritis (OA) is a chronic progressive disease commonly affecting the hip and knee joints. Although synthetic drugs are available and afford symptomatic relief, their side effects pose limitations to their continuous use. So, this research was focused on extracting drugs from indigenous medicinal plants that could have a beneficial effect on osteoarthritis. Dashmoolarishta is one such preparation whose effects have never been studied in comparison with recent drugs like hyaluronic acid (HA), hence this particular study was undertaken...
October 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29016352/in-vitro-ovicidal-activity-of-poly-lactic-acid-curcumin-nisin-co-entrapped-nanoparticle-against-fasciola-spp-eggs-and-its-reproductive-toxicity
#2
Oyetunde Oyeyemi, Odunayo Adegbeyeni, Ifeoluwa Oyeyemi, Jairam Meena, Amulya Panda
BACKGROUND: Curcumin and nisin have been widely reported for their antibacterial and anticancer potency. However, their therapeutic applications are hampered by several factors, which necessitate their development into nanosize ranges for improved delivery and activities. Their incorporation into a single nanosynthesized form may suggest desirable efficacy on parasites. The aim of the study was to assess the ovicidal activity of the curcumin-nisin polylactic acid (PLA) entrapped nanoparticle on the Fasciola eggs and its reproductive toxicity...
October 10, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29016351/ameliorative-effect-of-gallic-acid-on-doxorubicin-induced-cardiac-dysfunction-in-rats
#3
Temiday O Omóbòwálé, Ademola A Oyagbemi, Ayorinde M Folasire, Temitayo O Ajibade, Ebunoluwa R Asenuga, Olumuyiwa A Adejumobi, Olufunke E Ola-Davies, Orotusin Oyetola, Gana James, Adeolu A Adedapo, Momoh A Yakubu
BACKGROUND: The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because of the myriad of toxic sequelae associated with it. The aim of this study was to assess the protective effects of gallic acid (GA) on DOX-induced cardiac toxicity in rats. METHODS: Sixty male rats (Wistar strain) were used in this study. They were divided into six groups (A-F) each containing 10 animals. Group A was the control. Rats in Groups B, C, and D were treated with DOX at the dosage of 15 mg/kg body weight i...
October 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28988222/an-isobolographic-analysis-of-the-anti-nociceptive-effect-of-geraniin-in-combination-with-morphine-or-diclofenac
#4
Eric Boakye-Gyasi, Ella Anle Kasanga, Elvis Ofori Ameyaw, Wonder Kofi Mensah Abotsi, Robert Peter Biney, Christian Agyare, Eric Woode
BACKGROUND: Geraniin, a dehydroellagitannin, is a major component of the aqueous extract of the aerial parts of Phyllanthus muellerianus (Kuntze) Exell. (Euphorbiaceae). Several Phyllanthus species are traditionally used for painful disorders. The anti-nociceptive effects of the aqueous extract of the aerial parts of P. muellerianus and of geraniin have been scientifically established. The aim of the paper is to determine whether a combination of geraniin and diclofenac or geraniin and morphine leads to better anti-nociceptive effects...
October 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28988221/cocos-nucifera-water-improves-metabolic-functions-in-offspring-of-high-fat-diet-fed-wistar-rats
#5
Olufadekemi T Kunle-Alabi, Opeyemi O Akindele, Yinusa Raji
BACKGROUND: Maternal high fat diet has been implicated in the aetiology of metabolic diseases in their offspring. The hypolipidaemic actions of Cocos nucifera water improve metabolic indices of dams consuming a high fat diet during gestation. This study investigated the effects of C. nucifera water on metabolism of offspring of dams exposed to high fat diet during gestation. METHODS: Four groups of pregnant Wistar rat dams (n=6) were treated orally from Gestation Day (GD) 1 to GD 21 as follows: standard rodent feed+10 mL/kg distilled water (Control), standard rodent feed+10 mL/kg C...
October 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28981444/central-mediators-of-the-zymosan-induced-febrile-response
#6
Amanda Leite Bastos-Pereira, Daniel Fraga, Arturo Alejandro Dreifuss, Aleksander Roberto Zampronio
BACKGROUND: Zymosan is a fungal cell wall protein-carbohydrate complex that is known to activate inflammatory pathways through the Toll-like receptors and is commonly used to induce fever. Nevertheless, the central mediators that are involved in the zymosan-induced febrile response are only partially known. METHODS: The present study evaluated the participation of prostaglandins, substance P, endothelin-1 (ET-1), and endogenous opioids (eOPs) in the zymosan-induced febrile response by using inhibitors and antagonists in male Wistar rats...
October 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28981443/ameliorative-effect-of-azadirachta-indica-on-sodium-fluoride-induced-hypertension-through-improvement-of-antioxidant-defence-system-and-upregulation-of-extracellular-signal-regulated-kinase-1-2-signaling
#7
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Bukola Ayokunmi Alaba, Olufunke Eunice Ola-Davies, Olumuyiwa Abiola Adejumobi, Ebunoluwa Racheal Asenuga, Temitayo Olabisi Ajibade, Adeolu Alex Adedapo, Momoh Audu Yakubu
BACKGROUND: Toxicities due to fluoride exposure from natural and industrial sources occur commonly in man and animals with severe consequences ranging from mild cardiac derangements to sudden death. In this study, we investigated the protective effects of the methanol extract of Azadirachta indica (AI) against sodium fluoride (NaF)-induced hypertension and genotoxicity in rats. METHODS: Sixty rats were divided into six groups of ten rats each as follows: Group A, the control group received distilled water; Group B rats were administered NaF at 600 ppm in drinking water; Groups C and D rats were pre-treated with the methanol extract of AI and thereafter administered NaF at 600 ppm in drinking water for 7 consecutive days; Groups E and F rats were co-administered with AI and NaF...
October 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28981442/effect-of-l-carnitine-on-diabetes-induced-changes-of-skeletal-muscles-in-rats
#8
Shereen M Samir, Amr M Abbas, Sally M Safwat, Hanaa G Elserougy
BACKGROUND: Patients with diabetes mellitus (DM) are at risk of experiencing chronic complications such as retinopathy, nephropathy and myopathy. We aimed to evaluate the effects of L-carnitine on type II DM (T2DM)-induced biochemical, contractile and pathological changes in skeletal muscles of rats. METHODS: Thirty-two male Sprague Dawley rats were divided into the control, control+L-carnitine, T2DM and T2DM+L-carnitine groups. Plasma levels of glucose, insulin, malondialdehyde and antioxidants such as reduced glutathione, catalase and superoxide dismutase, haemoglobin A1c (HbA1c), insulin sensitivity index (ISI) as well as the contractile properties of the gastrocnemius muscle were measured...
October 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28981441/assessment-of-the-antioxidant-thrombolytic-analgesic-anti-inflammatory-antidepressant-and-anxiolytic-activities-of-leaf-extracts-and-fractions-of-tetracera-sarmentosa-l-vahl
#9
Mir Muhammad Nasir Uddin, Mohammad Shah Hafez Kabir, Mahmud Hasan, Zobaer Al Mahmud, N M Mahmudul Alam Bhuiya, Farhan Ahmed, Md Rakibul Hasan, Mohammad Tanvir Hosen, Mohammad Shahin Alam
BACKGROUND: The plant under investigation (Tetracera sarmentosa) is a dicotyledonous flowering plant and belongs to the family Dilleniaceae. The goal of our investigation was to determine whether the leaf extracts of this plant held any significant medicinal properties. METHODS: Leaves of T. sarmentosa were extracted with pure ethanol (EETS) and methanol (METS), and then methanol extract fractioned with n-hexane (NHFMETS) and chloroform (CHFMETS). The extracts and fractions were tested for antioxidant activity, which was measured by using qualitative and quantitative procedures...
October 5, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28917083/effects-of-single-or-combined-administration-of-salmon-calcitonin-and-omega-3-fatty-acids-versus-diclofenac-sodium-in-sodium-monoiodoacetate-induced-knee-osteoarthritis-in-male-wistar-rats
#10
Wale J Adeyemi, Luqman A Olayaki
BACKGROUND: There is a continuous search for a better therapy in osteoarthritis (OA) management. Therefore, this study investigated the effects of salmon calcitonin (Sct) and/or omega-3 fatty acids (N-3) relative to diclofenac sodium (DF) in induced knee osteoarthritic male Wistar rats. METHODS: The 40 rats that were used in this study were divided into 8 groups (n=5 rats), viz: Normal control; OA control; OA+N-3; OA+Low dose of Sct (Sct.Lw); OA+High dose of Sct (Sct...
September 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28917082/protective-effect-of-salusin-%C3%AE-and-salusin-%C3%AE-against-ethanol-induced-gastric-ulcer-in-rats
#11
Ayhan Tanyeli, Ersen Eraslan, Elif Polat, Tuğba Bal
BACKGROUND: Alcohol consumption has been found to be associated with gastric ulcers, including gastric mucosal lesions. Salusin-α and salusin-β are bioactive peptides having 28 and 20 amino acids, respectively. Salusin-α and salusin-β immunoreactivity has been detected in the stomach and in the intestines. It has been reported that the salusins regulate the cytokine levels and decrease the infarct area in the heart tissue after ischemia. In this study, we investigated the effects of the salusins in the gastric injury formed with ethanol...
September 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28902623/chronic-endurance-exercise-antagonizes-the-cardiac-ucp2-and-ucp3-protein-up-regulation-induced-by-nandrolone-decanoate
#12
Gholamreza Bayat, Mohammad Javan, Azadeh Khalili, Fatemeh Safari, Saeed Shokri, Sohrab Hajizadeh
BACKGROUND: Several lines of evidence revealed that chronic treatment of anabolic androgenic steroids (AASs) is accompanied with some cardiovascular side effects and in addition they also negatively mask the beneficial effects of exercise training on cardiac performance. METHODS: The present study examined whether the nandrolone decanoate (ND)-induced cardiac effects were mediated by changing the cardiac uncoupling protein 2 (UCP2) and 3 (UCP3) expression. Five groups of male wistar-albino rats including sedentary control (SC), sedentary vehicle (SV), sedentary nandrolone decanoate (SND), exercise control (EC), and exercise nandrolone decanoate (END) were used...
September 13, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28902622/functional-interaction-between-n-methyl-d-aspartate-receptor-and-ascorbic-acid-during-neuropathic-pain-induced-by-chronic-constriction-injury-of-the-sciatic-nerve
#13
Sepideh Saffarpour, Farinaz Nasirinezhad
BACKGROUND: Neuropathic pain is a chronic pain condition, which is resistant to therapy. Ascorbate was released because of the activation of glutaminergic neurons. Due to the important role of N-methyl-D-aspartate (NMDA) receptors in the pathophysiology of neuropathic pain, this study investigated the analgesic efficacy of ascorbic acid (AA) in neuropathic pain condition and the role of NMDA receptors in this effect. METHODS: For this purpose, adult male rats were randomly allocated to experimental groups (n=8 in each group)...
September 13, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28888089/antidiabetic-potential-of-polyphenolic-rich-fraction-of-tamarindus-indica-seed-coat-in-alloxan-induced-diabetic-rats
#14
Santosh Singh Bhadoriya, Aditya Ganeshpurkar, Ravi Pratap Singh Bhadoriya, Sanjeev Kumar Sahu, Jay Ram Patel
BACKGROUND: Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent. METHODS: Hydroethanolic seed coat extract of Tamarindus indica (HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study...
September 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28888088/possible-modulation-of-ppar-%C3%AE-cascade-against-depression-caused-by-neuropathic-pain-in-rats
#15
Shanky Garg, Vishwajit Ravindra Deshmukh, Pranav Prasoon
BACKGROUND: Sciatic nerve ligation causes neuropathic pain with chronic constriction injury (CCI). However, there is no published report on the effect of pioglitazone as an antidepressant in the treatment of depression induced by neuropathic pain with CCI in rats. The aim of this study was to evaluate the effect of pioglitazone as an antidepressant by targeting oxidative stress by the peripheral neuropathic pain model using the CCI of the sciatic nerve. METHODS: Behavioral studies were carried out to measure thermal hyperalgesia and cold allodynia as markers of neuropathic pain and force swim test for depression...
September 9, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28820735/the-use-of-sirna-as-a-pharmacological-tool-to-assess-a-role-for-the-transcription-factor-nf-il6-in-the-brain-under-in-vitro-and-in-vivo-conditions-during-lps-induced-inflammatory-stimulation
#16
Jelena Damm, Joachim Roth, Rüdiger Gerstberger, Christoph Rummel
BACKGROUND: Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain. METHODS: In this study, we tested the capacity of short interfering (si) RNA to silence the inflammatory transcription factor nuclear factor-interleukin 6 (NF-IL6) in brain cells under in vitro and in vivo conditions...
August 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28777735/evidence-for-the-involvement-of-the-gaba-ergic-pathway-in-the-anticonvulsant-activity-of-the-roots-bark-aqueous-extract-of-anthocleista-djalonensis-a-chev-loganiaceae
#17
Germain Sotoing Taiwe, Arielle Larissa Ndieudieu Kouamou, Armelle Rosalie Mbang Ambassa, Joseph Renaud Menanga, Thierry Bang Tchoya, Paul Desire Djomeni Dzeufiet
BACKGROUND: The root bark of Anthocleista djalonensis A. Chev. (Loganiaceae) is widely used in traditional medicine in Northern Cameroon to treat epilepsy and related conditions, such as migraine, insomnia, dementia, anxiety, and mood disorders. METHODS: To investigate the anticonvulsant effects and the possible mechanisms of this plant, an aqueous extract of Anthocleista djalonensis (AEAD) was evaluated by using animal models of bicuculline-, picrotoxin-, pilocarpine-, and pentylenetetrazole-induced convulsions...
August 4, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28771434/cutaneous-temperature-sensitivity-alteration-in-subjects-with-chronic-stroke-sequelae-pharmacological-perspectives
#18
Artur Cesar Aquino Santos, Fábio Marcon Alfieri, Linamara Rizzo Battistella
BACKGROUND: Stroke can result in body temperature sensitivity changes. This study analyzed abnormal temperature perception of patients with stroke and the use of vasoactive drugs. METHODS: A cross-sectional retrospective study was carried out consisting of 100 patients (55.6±12.9 years old), from both genres, with either hemorrhagic or ischemic stroke, with unilateral hemiplegia or hemiparesis. Subjects had axillary temperature and different temperature sensitivities of the limbs measured using a visual analog scale (VAS)...
August 3, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28771433/the-impact-of-vitamin-c-on-the-relationship-among-inflammation-lipid-peroxidation-and-platelet-activation-during-analgesic-nephropathy-in-rats
#19
Nikola Hadzi-Petrushev, Dine Mitrov, Vladimir Kostovski, Mitko Mladenov
BACKGROUND: Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin F2α (8-iso-PGF2α) and platelet activation as well as the relative contribution of the pro-inflammatory markers interleukin (IL)-1β and tumor necrosis factor-α (TNF-α) in enhanced 8-iso-PGF2α biosynthesis, as a complementary onset during analgesic nephropathy induced by chronic treatment with paracetamol...
August 3, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28771432/antidiarrheal-and-antinociceptive-activities-of-ethanol-extract-and-its-chloroform-and-pet-ether-fraction-of-phrynium-imbricatum-roxb-leaves-in-mice
#20
Mohammed Munawar Hossain, Mohammad Shah Hafez Kabir, Md Abu Monsur Dinar, Md Saiful Islam Arman, Md Mominur Rahman, S M Zahid Hosen, Raju Dash, Mir Muhammad Nasir Uddin
BACKGROUND: The objective of the study was to evaluate the antidiarrheal and antinociceptive activities of ethanol extract and its chloroform and pet ether fraction of Phrynium imbricatum (Roxb.) leaves in mice. METHODS: In the present study, the dried leaves of P. imbricatum were subjected to extraction with ethanol, and then it was fractioned by chloroform and pet ether solvent. Antidiarrheal effects were tested by using castor oil-induced diarrhea, castor oil-induced enteropooling, and gastrointestinal transit test...
August 3, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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