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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/29432206/evaluation-of-hematological-alterations-after-therapeutic-use-of-dipyrone-in-healthy-adults-a-prospective-study
#1
Ernane C de Souza, Dalyara M Matos, Milainy R Viana, Marcela C O Alvim, Herval L Bonfante, Alexandre F Pinto, Jorge W L Nascimento
BACKGROUND: Dipyrone is a non-narcotic analgesic/antipyretic widely used in some countries but prohibited in others due to suspected risk of agranulocytosis. The primary goal of this study was to evaluate hematological alterations in healthy adult volunteers after treatment with dipyrone. METHODS: The study enrolled 30 healthy volunteers of both genders, aged 19-37 years. They received tablets containing 500 mg of dipyrone sodium to be used four times daily for 7 consecutive days...
February 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29420306/dose-dependent-effects-of-vitamin-1-25-oh-2d3-on-oxidative-stress-and-apoptosis
#2
Cagri Cakici, Turkan Yigitbasi, Sule Ayla, Hadi Karimkhani, Feyza Bayramoglu, Pakize Yigit, Ertugrul Kilic, Nesrin Emekli
Background The purpose of this study is to examine the dose-dependent effects of vitamin 1,25(OH)2D3 on apoptosis and oxidative stress. Methods In this study, 50 male Balb/c mice were used as control and experiment groups. The mice were divided into 5 groups each consisting of 10 mice. Calcitriol was intraperitoneally administered as low dose, medium dose, medium-high dose and high dose vitamin D groups (at 0.5, 1, 5 and 10 μg/kg, respectively), for three times a week during 14 days. At the end of the study, annexin V was measured by enzyme-linked immunosorbent assay method, and total antioxidant capacity and total oxidant status values were measured by colorimetric method in serum...
February 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29408799/the-case-for-a-distinctive-philosophy-of-physiology-and-pathophysiology
#3
Hutan Ashrafian
What is an organ and what is an organ system? According to the 'standard' hierarchical model of physiology, each living organism comprises of organ systems including those that offer sensory and control functions (nervous system), energy accumulation (gastrointestinal system), internal dissipation (circulatory system) and mobility (musculoskeletal system). Each organ system in turn is comprised of individual organs. This taxonomy has conceptual flaws as not every organ has a single organ system function but may participate in a myriad of physiological functions...
February 6, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29408798/conservative-treatment-of-postoperative-chylothorax-a-case-report
#4
Sachinkumar Wagh, Sanjay Deshmukh, Shrikant Ankolikar
BACKGROUND: Chylothorax is a well-documented complication of thoracic trauma and is associated with high rates of morbidity and mortality. Treatment for chylothorax includes conservative measures (total parenteral nutrition, pleural drainage, and pleurodesis) and surgery (thoracic duct ligation). CASE PRESENTATION: We present the case of a 65-year-old man who developed chylothorax after an elective surgical procedure. In this report conservative treatment aims to reduce chyle flow, to drain the pleural cavity in an effective manner, and to prevent chronic sequelae...
February 6, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29397387/losartan-improves-renal-function-and-pathology-in-obese-zsf-1-rats
#5
Zhi Su, Deborah Widomski, Arthur Nikkel, Laura Leys, Marian Namovic, Diana Donnelly-Roberts, Murali Gopalakrishnan, Steve McGaraughty
BACKGROUND: Losartan, a blocker of the angiotensin II type I receptor, is an important part of the standard of care for diabetic nephropathy (DN). The obese ZSF-1 rats display many aspects of the clinical features of human Type II DN. The current study was designed to examine the treatment effects of losartan on obese ZSF-1 rats and to evaluate the impact of the onset of dosing on efficacy. MATERIALS AND METHODS: The rats (7-10 weeks) underwent a right uninephrectomy (Unx) or sham surgery...
February 5, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29397386/blood-troponin-levels-in-acute-cardiac-events-depends-on-space-weather-activity-components-a-correlative-study
#6
Eliiyahu Stoupel, Richardas Radishauskas, Gailute Bernotiene, Abdonas Tamoshiunas, Daiva Virvichiute
BACKGROUND: Many biological processes are influenced by space weather activity components such as solar activity (SA), geomagnetic activity (GMA) and cosmic ray activity (CRA). Examples are total mortality, acute myocardial infarction (AMI), stroke (cerebrovascular accident), sudden cardiac death, some congenital maladies (congenital heart disease and Down syndrome), many events in neonatology, ophtalmology, blood pressure regulation, blood coagulation, inflammation, etc. The aim of this study was to check if the level of blood troponins (Tns) - markers of myocardial damage and recognized components of modern description of AMI - is connected with the mentioned space weather parameters...
February 5, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29389665/acorus-calamus-a-bio-reserve-of-medicinal-values
#7
REVIEW
Amrita Devi Khwairakpam, Yengkhom Devi Damayenti, Anindita Deka, Javadi Monisha, Nand Kishor Roy, Ganesan Padmavathi, Ajaikumar B Kunnumakkara
Many plants are found to possess reliable pharmacological properties and have started to attract the attention of researchers. One such holistic plant is Acorus calamus, commonly known as sweet flag, belonging to the rhizomatous family Acoraceae. The different parts of this plant, such as the leaves and rhizomes, are used traditionally in different medicinal preparations for the treatment of various ailments including arthritis, neuralgia, diarrhoea, dyspepsia, kidney and liver troubles, eczema, sinusitis, asthma, fevers, bronchitis, hair loss, and other disorders...
February 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29381472/chromatographic-fingerprint-analysis-antioxidant-properties-and-inhibition-of-cholinergic-enzymes-acetylcholinesterase-and-butyrylcholinesterase-of-phenolic-extracts-from-irvingia-gabonensis-aubry-lecomte-ex-o-rorke-baill-bark
#8
Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Ayodele Jacob Akinyemi, Mary Abiola Okesola, Aline Augusti Boligon, Marli Matiko Anraku de Campos
BACKGROUND: Irvingia gabonensis stem bark is a medicinal plant used in most parts of Africa to manage a number of ailments including neurodegenerative diseases that occur without scientific basis. This work characterized the phenolic composition, evaluated the cholinergic enzymes (acetylcholinesterase, AChE and butyrylcholinesterase, BChE) inhibition, and assessed the antioxidant activity of phenolic extracts from I. gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. METHODS: Total phenol and flavonoids content was evaluated in addition to antioxidant activity as shown by Fe2+ chelation, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability, and 2,2-azino-bis-(3-ethylbenthiazoline-6-sulfonic acid) (ABTS) radical scavenging ability...
January 30, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29360627/launaea-taraxacifolia-willd-amin-ex-c-jeffrey-inhibits-oxidative-damage-and-econucleotidase-followed-by-increased-cellular-atp-in-testicular-cells-of-rats-exposed-to-metropolitan-polluted-river-water
#9
Jacob K Akintunde, Michael O Aina, Aline A Boligon
BACKGROUND: Humans are directly/indirectly exposed to hazardous chemicals from the aquatic environment. We investigated the protection of the Launea taraxacifolia methanolic extract (LTME) on the hydroxyl steroid dehydrogenases [(∆5-3β-hydroxyl steroid dehydrogenase (∆5-3β-HSD) and the ∆5-17β-hydroxyl steroid dehydrogenase (∆5-17β-HSD), testicular 5'-nucleotidase and lactate dehydrogenase (LDH)] activities as well as the key indicators of oxidative stress in germinal epithelial cells of rats induced with surulere polluted river water (SPRW)...
January 23, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29306925/calcium-sensitization-mechanisms-in-detrusor-smooth-muscles
#10
REVIEW
Irfan Anjum
The contraction of detrusor smooth muscles depends on the increase in intracellular calcium. The influx of calcium from the plasma membrane calcium channels and calcium release from the sarcoplasmic reticulum give rise to intracellular calcium. Under the pathophysiological conditions, the increased sensitivity of regulatory and contractile proteins to calcium also plays an important role in maintaining the spontaneous detrusor smooth muscle activity. Many proteins have been identified to play a role in calcium sensitization...
January 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29303776/evaluation-of-morning-glory-jacquemontia-tamnifolia-l-griseb-leaves-for-antioxidant-antinociceptive-anticoagulant-and-cytotoxic-activities
#11
Mohammad Shahadat Hossain, A S M Ali Reza, Md Masudur Rahaman, Mst Samima Nasrin, Mohammed Rasib Uddin Rahat, Md Rabiul Islam, Md Josim Uddin, Md Atiar Rahman
BACKGROUND: The present study was planned to investigate the phytochemical, antioxidant, antinociceptive, anticoagulant and cytotoxic activities of the Jacquemontia tamnifolia (L.) Griseb leaf methanol extract (MExJT) in the laboratory using both in vitro and in vivo methods. METHODS: Phytochemical values, namely, total phenolic and flavonoid contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging effect and FeCl3 reducing power effects, were studied by established methods...
January 5, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29303775/is-antiarrhythmic-drug-effectiveness-stable-extrapolating-icd-in-different-space-weather-conditions
#12
LETTER
Eliiyahu G Stoupel
No abstract text is available yet for this article.
January 5, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29283882/sildenafil-a-phosphodiesterase-5-inhibitor-offers-protection-against-carbon-tetrachloride-induced-hepatotoxicity-in-rat
#13
Olorunfemi R Molehin, Anne A Adeyanju, Stephen A Adefegha, Oluwasanmi O Aina, Blessing A Afolabi, Ayorinde O Olowoyeye, Jesutomi A Oyediran, Opeyemi R Oladiran
BACKGROUND: Elevation of phosphodiesterase-5 (PDE5) activity converts cyclic guanosine monophosphate (cGMP) to 5'-GMP, a mechanism that could be associated with drug-mediated hepatotoxicity. This study investigated whether selective inhibition of PDE5 by sildenafil could offer protection against hepatotoxicity induced by carbon tetrachloride (CCl4). METHODS: CCl4 (0.5 mL/kg) was administered intraperitoneally to induce hepatotoxicity. The control group received normal saline...
December 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29267168/amla-emblica-officinalis-improves-hepatic-and-renal-oxidative-stress-and-the-inflammatory-response-in-hypothyroid-female-wistar-rats-fed-with-a-high-fat-diet
#14
P Rajaa Muthu, Zachariah Bobby, P Sankar, V Vickneshwaran, Sajini Elizabeth Jacob
BACKGROUND: We investigated the protective effects of amla (Emblica officinalis) on the pathogenesis of oxidative stress (OS) and inflammatory response in hypothyroid rats fed with a high-fat diet (HFD) as an experimental model of hypothyroidism (HT) with obesity. MATERIALS AND METHODS: A total of 80 female wistar rats (5-months-old) were divided into eight different groups. Propylthiouracil (PTU) and HFD were used to induce the experimental HT and obesity, respectively...
December 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29232194/persistent-ventricular-bigeminy-during-anesthesia-in-pediatric-patients-a-case-report-of-an-11-year-old-child
#15
Sheetal Dalal, Vikas Chaudhari
An 11-year-old male child with fractures in both bones in his left forearm presented for open reduction and internal fixation. The pre-anesthetic check-up and investigations did not reveal any pre-existing underlying cardio-respiratory disease. The patient had an uneventful peri-operative period during the operation and was comfortable without any anxiety or restlessness. After an uneventful induction and intubation as per routine protocol, the patient received 600 mg of amoxicillin+clavunate intravenously as an antibiotic...
December 12, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29220885/indexes-of-the-erythropoietin-level-in-the-blood-plasma-of-chronic-heart-failure-patients-with-anemia
#16
Kamala Kh Zahidova
BACKGROUND: Anemia aggravates the disease course and the survival rate of chronic heart failure (CHF) patients. The purpose of the study was to investigate the level of erythropoietin (EPO) in CHF patients with anemic syndrome, with the aim to more accurately assess the severity of the disease and its treatment, depending on the anemia degree. METHODS: Patients with ischemic CHF of I-IV functional class (FC) with and without anemia were examined (total number of patients=208, patients with anemia=174)...
December 7, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29176020/antidiarrheal-and-antimicrobial-activities-of-the-ethanol-extract-from-the-icacina-senegalensis-root-bark
#17
Godwin C Akuodor, Ndubuisi N Nwobodo, Anthony U Megwas, Joseph L Akpan, Daniel C Nwachukwu, Ebere C Asika, Kingsley C Chilaka
BACKGROUND: The Icacina senegalensis root bark is traditionally used for the treatment of gastrointestinal disorders in Nigeria. To date, no scientific study has substantiated or refuted this claim. METHODS: The antidiarrheal and antimicrobial activities of the ethanol root bark extract were investigated in rats and against some selected diarrhea-causing microorganisms. RESULTS: The extract significantly decreased the frequency of castor oil-induced diarrhea, and inhibited the masses and volumes of intestinal fluid accumulation in the castor oil-induced enteropooling method...
November 25, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29161233/swimming-but-not-vitamin-e-ameliorates-prothrombotic-state-and-hypofibrinolysis-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#18
Hussein F Sakr, Amr M Abbas, Mohamed A Haidara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with a systemic procoagulant hypofibrinolysis state that is considered as a risk factor for microangiopathy and peripheral vascular diseases. Swimming exercise ameliorates the metabolic dysfunction in type 2 diabetes. Vitamin E is a natural antioxidant that reduces the risk of endothelial dysfunction in metabolic syndrome. The aim of the present study is to investigate the effect of combined swimming exercise with vitamin E on coagulation as well as blood fibrinolysis markers in rats with NAFLD...
November 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29125830/inflammation-fever-and-body-temperature-under-febrile-conditions
#19
EDITORIAL
Joachim Roth, Michal Horowitz
No abstract text is available yet for this article.
November 27, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29040066/evaluation-of-oral-multi-herbal-preparation-of-dashmoolarishta-on-mice-model-of-osteoarthritis
#20
Yashashri C Shetty, Santosh Godbharle, Smita Brahma, Sweta Salgaonkar, Nirmala N Rege
BACKGROUND: Osteoarthritis (OA) is a chronic progressive disease commonly affecting the hip and knee joints. Although synthetic drugs are available and afford symptomatic relief, their side effects pose limitations to their continuous use. So, this research was focused on extracting drugs from indigenous medicinal plants that could have a beneficial effect on osteoarthritis. Dashmoolarishta is one such preparation whose effects have never been studied in comparison with recent drugs like hyaluronic acid (HA), hence this particular study was undertaken...
November 27, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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