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Journal of Basic and Clinical Physiology and Pharmacology

Abolfazl Khajavi Rad, Reza Mohebbati
No abstract text is available yet for this article.
August 15, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Agbonlahor Okhuarobo, Ighodaro Igbe, Abdulmajid Yahaya, Zakariya Sule
Background The aim of the study was to determine the effect of caffeine on alcohol consumption with or without deprivation and alcohol-induced conditioned place preference. Methods In the present study, we examined the effects of caffeine (2.5, 5 and 10 mg/kg) on alcohol consumption in Wistar rats with or without periods of deprivation in an unlimited-access, two-bottle, free choice drinking procedure after a stable baseline alcohol consumption was established. Conditioned place preference (CPP) was established by intraperitoneal injections of alcohol (2 g/kg) in a 12-day conditioning schedule in mice...
August 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Jeff Moore, Sarah Northway, Nicole Wells, Emily Woolf, Michael J Buono
BACKGROUND: The purpose of this study was to measure sweat rate during exercise in the heat after directly inhibiting carbonic anhydrase (CA) in eccrine sweat glands via transdermal iontophoresis of acetazolamide. It was hypothesized that if CA was important for sweat production, local administration of acetazolamide, without the confounding systemic effects of dehydration typically associated with past studies, would have a significant effect on sweat rate during exercise. METHODS: Ten healthy subjects volunteered to exercise in the heat following acetazolamide or distilled water iontophoresis on the forearm...
August 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Oumar Mahamat, Tume Christopher, Njouonkou Andre-Ledoux, Amadoh Jude, Nfor Ndiane, Kamanyi Albert
Background Globally, Termitomyces letestui is used by different communities to treat various illnesses, including bacterial infection, although with limited scientific evidence. The current study aims to assess the immunomodulatory and antibacterial properties of the water extract of a wild mushroom, T. letestui in mice model. Methods The base study was completed following the standard methods and procedures using white mice Mus musculus. The immunomodulatory was investigated for humoral and cell-mediated response in both the normal and dexamethasone-immunosuppressed mice...
August 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Hilal Ahmad, Vijay L Kumar
Ulcerative colitis (UC) is a chronic mucosal inflammation of the large intestine restricted to the rectum and colon. Its clinical course follows an intermittent pattern with episodes of relapse, followed by remission and eventually resulting in mucosal damage. Although there is no permanent cure for UC, the currently available pharmacotherapy aims to induce and maintain clinical remission, promote the healing of colonic mucosa and avert any surgical intervention. The conventional drug therapy comprising of 5-aminosalicylates, thiopurines and corticosteroids has advanced recently in terms of formulations and dosing schedule, resulting in improved efficacy, safety and compliance...
August 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Md Sajjad Ul Hoque, Mohammed Sohel Chowdhury, Arkajyoti Paul, Jackie Barua, Syeda Sakiatuz Zannat, Md Mehedi Hasan, Shaibal Das Gupta, Sagar Barua, Sabbir Ahmed, Mohammad Shah Hafez Kabir
Background The current study evaluates the analgesic effect of different extracts of Hopea odorata leaves in mice followed by molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADME/T) analysis of isolated compounds derived from the plant with the COX-1 enzyme. Methods In the present study, the dried leaves of H. odorata were subjected to extraction using methanol, ethanol, and water. In vivo analgesic activity was evaluated by using the acetic acid-induced writhing test and formalin-induced paw licking test, and in silico molecular docking and ADME/T study were performed using Schrödinger Maestro (version 11...
August 7, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Siti Syairah Mohd Mutalip, Aishah Mohd Shah, Mashani Mohamad, Vasudevan Mani, Siti Nooraishah Hussin, Gurmeet Kaur Surindar Singh
Background Testosterone, nandrolone, and stanozolol are among the highly consumed anabolic androgenic steroids (AASs). Although the desired effects of AAS are being achieved by the abusers, unfortunately, this leads to numerous physical and physiological side effects. The present study was designed to investigate and determine whether early pubertal exposure to AAS treatment had detrimental effects on blood testosterone and estradiol concentrations, mating behavior, and pregnancy outcome during the pubertal period in male rats...
August 3, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Shakthi R K Devan, Surendar Arumugam, Ganesh Shankar, Suresh Poosala
BACKGROUND: The prevalence of obesity is reported to be increasing owing to the high intake of dietary fat and is a predisposing risk factor with associated complex metabolic syndromes in the human population. Preclinical rodent models play a pivotal role in understanding the pathogenesis of obesity and development of new treatment strategies for humans. High-fat-diet (HFD)-induced rodents are used for chronic obesity models owing to their quick adaptation to high-fat diets and rapid body weight gain and different rats (Wistar Sprague-Dawley and Lewis) have been used by various researchers...
August 2, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Deotima Sarkar, Arijit Chakraborty, Adipa Saha, Amar K Chandra
Background Iodine is a nonpareil constituent of thyroid hormones (THs) and a prime regulator of thyroid gland functioning. Although essential at recommended levels for the prevention of iodine deficiency disorders (IDDs), exposure to excess iodine reportedly causes hypothyroidism, hyperthyroidism, and several other emerging deleterious impacts. The objective of the present study is to explore the influence of excess iodide exposure on carbohydrate and lipid metabolism along with the histoarchitecture of certain associated organs such as the pancreas, liver, kidney, and skeletal and cardiac muscle because information on those aspects was found to be scanty...
August 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Nitima Tatiya-Aphiradee, Waranya Chatuphonprasert, Kanokwan Jarukamjorn
Ulcerative colitis (UC) is an idiopathic relapsing inflammatory disease. Although the etiology of UC remains unclear, it could be characterized by inflammation of the intestinal mucosa, starting from the rectum and potentially involving the entire colon. The immune response and inflammatory pathway of UC have shown that tissue damage is driven by dynamic and complexes of cells and cytokines. Various types of cells, including antigen-presenting cells (dendritic cells and macrophages), T helper cells, regulatory T cells, and natural killer T cells, play a crucial role in UC pathogenesis by regulation, suppression, and maintenance of inflammation...
July 31, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Dilip Chandrasekhar, Athira Dollychan, Bincy Mary Roy, Shinu Cholamughath, Jaffer Chalil Parambil
BACKGROUND: A prospective observational study was carried out over a period of 6 months among the inpatients and outpatients in the departments of general medicine, urology, obstetrics, and gynecology of a tertiary level referral hospital in south Malabar region of Kerala to assess the prevalence of various bacterial isolates and their changing susceptibility to antimicrobial agents and to evaluate the pattern of antibiotic utilization in urinary tract infection (UTI). METHODS: A total of 680 samples were analyzed from December 2015 to May 2016; among them, only 74 patients met the inclusion criteria...
July 31, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Newman Osafo, David D Obiri, Aaron O Antwi, Oduro K Yeboah
Background Our earlier studies had given evidence of the traditional application of Xylopia aethiopica in the management of inflammation. The principal constituent obtained from its bio-fractionation is xylopic acid. It is a crystalline diterpene that belongs to the class of kauranes. This work sets out to investigate the anti-inflammatory potential of the xylopic acid isolated from the dried fruit of X. aethiopica. Methods A preliminary anti-inflammatory study, using the protein denaturation model, and in vivo anti-inflammatory assay were employed in the investigation of acute inflammation...
July 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Andriy L Zagayko, Tetiana Ye Kolisnyk, Olena I Chumak, Olena A Ruban, Oleh M Koshovyi
Background Vaccinium myrtillus leaves are known to be rich in phenols and have been used in traditional medicine as an antidiabetic remedy. This study evaluated the powder extract of V. myrtillus leaves obtained with the use of L-arginine and myo-inositol for anti-obesity and lipid-lowering potential in hamsters. Methods Standard phytochemical methods were used to determine the total phenolic and total flavonoid contents of the extract. The obesity condition was induced in Syrian hamsters by feeding them with highly palatable fat- and sugar-rich diet (40...
July 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Md Imamul Islam, Meena Afroze Shanta, Milon Mondal, Nazia Hoque, Senjuti Majumder, Taksim Ahmed, Md Sohel Rana
Background This study was designed to evaluate the free radical scavenging property of chloroform extract of the bark of Stereospermum chelonoides (SCBC) and to investigate its potential in Alzheimer's disease and inflammation, two oxidative stress related disorders. Methods Preliminary phytochemical analysis and in vitro antioxidant potential of SCBC were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, cupric reducing antioxidant capacity (CUPRAC) and total antioxidant capacity determination assay...
July 21, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Marie Stéphanie Chekem Goka, Maurice Ducret Awouafack, Marc Lamshöft, Landry Lienou Lienou, Gildas Tetaping Mbemya, Fabrice Boyom Fekam, Pierre Tane, Phélix Bruno Telefo
Background Aloe buettneri, Dicliptera verticillata, Hibiscus macranthus and Justicia insularis are medicinal plants used in the western region of Cameroon to cure infertility among women. This experiment was designed to compare the effect of the aqueous extracts of A. buettneri (AAB), D. verticillata (ADV), H. macranthus (AHM), J. insularis (AJI), their mixture (AME) and the extract obtained from the mixture of their powders (AMP) on some parameters of reproduction. Materials and methods High-performance liquid chromatography coupled with the mass spectrometry (HPLC-MS) was used to detect the constituents of different extracts...
July 21, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Ahmed Abdelsadik
BACKGROUND: Obese patients have a higher risk of developing different metabolic syndromes (MeS), including acute pancreatitis (AP). Although obese individuals are more prone to MeS and more susceptible to local and systemic inflammation in response to AP, thus causing long-lasting hospitalization, higher morbidity and mortality, their underlying mechanisms remain unclear. This study aimed to investigate the relationship between obesity and the outcomes of AP in the rat model of AP. METHODS: To assess the link between obesity and AP, 40 male albino rats were divided into two groups: control and those given a high-fat diet for 12 weeks...
July 11, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Meghana Adoor, Sriranjini S Jaideep, M U Sujan, Boris W Kramer, T R Raju, Talakad N Sathyaprabha
Background The current exploratory study was aimed at estimating measures of blood pressure variability (BPV) and baroreflex sensitivity (BRS) in a healthy population in the Indian sub-continent. Methods One hundred and forty-two healthy subjects were recruited for the study. Blood pressure (BP) was recorded continuously for 15 min using the Finometer (Finapres Medical Systems, The Netherlands). For offline analysis, Nevrokard cardiovascular parameter analysis (CVPA) software (version 2.1.0) was used for BPV analysis...
July 26, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Mohammad Hossein Moghimi, Seyed Nejat Hosseini, Vahid Salehi, Kourosh Kamali
Background Pregabalin is a gamma-aminobutyric acid analog which seems to be effective in different neuropathic pains, as well as in incisional and inflammatory injuries. This study evaluated the effectiveness and safety of pregabalin on pain relief post herniorrhaphy. Methods In this randomized clinical trial, 60 men were chosen for unilateral inguinal herniorrhaphy under spinal anesthesia. The participants were randomly divided into two groups. The investigation (pregabalin) group received 300 mg of oral pregabalin 2 h before and 150 mg of pregabalin 12 and 24 h after surgery in addition to routine postoperative medication and 1 mg/kg of pethidine as needed...
July 26, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Deepak Gupta, Sarwan Kumar, Berhane Seyoum
No abstract text is available yet for this article.
July 26, 2018: Journal of Basic and Clinical Physiology and Pharmacology
Varinder Singh, Pawan Krishan, Richa Shri
Background Oxidative stress is strongly implicated in ischemia reperfusion (IR)-mediated functional and neuronal impairment. Therefore, strategies employing antioxidants to reverse the damage due to IR are being investigated. Allium schoenoprasum L. is a culinary medicine whose antioxidant properties are well documented but whose neuroprotective potential has not been examined. Hence, the present study was designed to evaluate the effect of A. schoenoprasum leaf extract (ASLE) on functional deficit against IR-induced cerebral injury in mice...
July 26, 2018: Journal of Basic and Clinical Physiology and Pharmacology
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