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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/28222030/sub-chronic-indomethacin-treatment-and-its-effect-on-the-male-reproductive-system-of-albino-rats-possible-protective-role-of-black-tea-extract
#1
Ishwar B Bagoji, Gavishiddappa A Hadimani, Saeed M Yendigeri, Kusal K Das
BACKGROUND: Indomethacin is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) to treat inflammation, arthritis and joint pains. Unfortunately, it has a wide range of adverse effects on the physiological system, including gonads. This study aimed to assess possible beneficial effects of black tea extract (BTE) against indomethacin-induced alteration of gonadal hormone levels in male rats. MATERIALS AND METHODS: Adult male rats were divided into Group I (control), Group II (indomethacin, 5 mg/kg body weight [bwt...
February 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28222029/effect-of-cardiovascular-and-muscular-endurance-is-not-associated-with-stress-fracture-incidence-in-female-military-recruits-a-12-month-follow-up-study
#2
Mickey Scheinowitz, Ran Yanovich, Nurit Sharvit, Michal Arnon, Daniel S Moran
BACKGROUND: Stress fracture (SF) is a common injury among military recruits, especially among women, during the army basic training (ABT). The purpose of this study was to evaluate the effects of health habits and physical activity before recruitment on the fitness level and the incidence of SF during the 4-month ABT. MATERIALS AND METHODS: We screened 226 female recruit volunteers (weight: 60.5±10 kg; height: 163±6 cm) from an integrated combat unit and 124 aged-matched female controls (weight: 57...
February 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28207414/anti-aging-effects-of-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-immunosuppressive-drug-on-the-enzymatic-and-non-enzymatic-oxidative-stress-parameters-in-an-experimental-model
#3
Soma Hosseini, Mohammad Abdollahi, Gholamreza Azizi, Mohammad Javad Fattahi, Noshin Rastkari, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Abbas Mirshafiey
BACKGROUND: The anti-aging property of β-D-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory and immunosuppressive agent was investigated on several determinants relative to the oxidative stress in an animal model. MATERIALS AND METHODS: Sprague-Dawley rats were used for evaluating the safety and efficacy properties of M2000 on some oxidative stress enzymes, including the following: mitochondrial superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX1), glutathione S-transferase (GST), myeloperoxidase (MPO), and inducible nitric oxide synthase (iNOS) gene expression by real-time PCR...
February 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28132032/effect-of-salacia-reticulata-w-and-clitoria-ternatea-l-on-the-cognitive-and-behavioral-changes-in-the-streptozotocin-induced-young-diabetic-rats
#4
R Rajashree, Rajani Patil, Sanjiva D Khlokute, Shivaprasad S Goudar
BACKGROUND: Diabetes mellitus (DM) of juvenile onset affects both the peripheral and central nervous systems (CNS). However, central effects are less documented and studied than peripheral deficits. Currently, the only feasible treatment available for type 1 DM (T1DM) is insulin which has its own limitations. Hence, an alternative therapy, especially a newer herbal formulation is very much the need of the time. The present study aimed to determine the effects of the alcoholic extracts of roots of the Salacia reticulata W...
January 30, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28121617/antidiabetic-effect-of-ruta-montana-l-in-streptozotocin-induced-diabetic-rats
#5
Omar Farid, Morad Hebi, Mohammed Ajebli, Ahmed El Hidani, Mohamed Eddouks
BACKGROUND: Ruta montana (L.) is known as a medicinal plant with many beneficial effects, including those that can be used in the treatment of diabetes. The objective of the study was to investigate the antidiabetic effect of this plant in diabetic rat. MATERIALS AND METHODS: This study investigated the effects of an aerial part aqueous extract (APAE) of Ruta montana (L.) (RM) at a dose of 5 mg/kg on blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats...
January 25, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28121616/investigation-of-antinociceptive-activity-of-methanolic-extract-of-persicaria-orientalis-leaves-in-rodents
#6
Prawej Ansari, Md Josim Uddin, Shafia Akther, Shofiul Azam, Md Kayes Mahmud, Sohel Bin Azad, Ahsan Ullah, J M A Hannan
BACKGROUND: This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation. METHODS: An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in which the hot-plate and tail immersion methods were applied to explore the acute effect of P. orientalis on analgesia. The potency to inhibit chronic inflammation in mice was justified by the carrageenan-induced paw edema and formalin-induced edema methods...
January 25, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28110314/long-term-exposure-to-a-butter-rich-diet-induces-mild-to-moderate-steatosis-in-chang-liver-cells-and-swiss-albino-mice-models
#7
Thomas John Philip Nalloor, Nitesh Kumar, Kasinathan Narayanan, Vasanth Raj Palanimuthu
BACKGROUND: Butter is one of the widely used fats present in the diet. However, there is no satisfactory study available that evaluates the effect of a high-fat diet containing butter as the principal fat on the development of non-alcoholic fatty liver disease (NAFLD). METHODS: In the present study, butter was used for the development of steatosis in Chang liver cells in an in vitro study and Swiss albino mice in an in vivo study. In vitro steatosis was established, and butter was compared with oleic acid in Chang liver cells using an oil red O (ORO)-based colorimetric assay...
January 23, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28099126/aminoguanidine-pretreatment-prevents-methotrexate-induced-small-intestinal-injury-in-the-rat-by-attenuating-nitrosative-stress-and-restoring-the-activities-of-vital-mitochondrial-enzymes
#8
Kasthuri Natarajan, Premila Abraham, Rekha Kota, Dhayakani Selvakumar
BACKGROUND: One of the major toxic side effects of methotrexate (MTX) is enterocolitis, for which there is no efficient standard treatment. Nitric oxide overproduction has been reported to play an important role in MTX-induced mucositis. This study was designed to investigate whether pretreatment with aminoguanidine (AG) - a selective iNOS inhibitor - prevents MTX-induced mucositis in rats. MATERIALS AND METHODS: Rats were pretreated with AG (30 and 50 mg/kg body weight) i...
January 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076315/meteorological-parameters-and-pollutants-on-asthma-exacerbation-in-bangalore-india-an-ecological-retrospective-time-series-study
#9
Kirthana U Kunikullaya, Ambarish Vijayaraghava, P Asha, Radhika Kunnavil, B V MuraliMohan
BACKGROUND: Literature has shown a significant association between asthma exacerbations and pollutant levels during that time. There is very limited evidence in India, especially Bangalore, for impacts of meteorological changes and pollution on asthma hospital admissions in adults. The objective was to study the impact of air pollution and meteorological parameters on asthma exacerbation in Bangalore. METHODS: This study quantitatively analyzed the relation between acute exacerbations of asthma and related admissions to the hospital with the air pollution and the meteorological conditions during that time...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076314/in-vivo-sedative-and-hypnotic-activities-of-methanol-extract-from-the-leaves-of-jacquemontia-paniculata-burm-f-hallier-f-in-swiss-albino-mice
#10
Md Jakaria, Chayan Dhar Clinton, Mukimul Islam, Mohammad Belal Talukder, Md Shariful Islam, Syed Mohammed Tareq, Shaikh Bokhtear Uddin
BACKGROUND: The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. METHODS: The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076313/ethnopharmacological-investigation-of-the-aerial-part-of-phragmites-karka-poaceae
#11
Ramiz Ahmed Sultan, Mohammad Shah Hafez Kabir, Mir Muhammad Nasir Uddin, Mohi Uddin, Zobaer Al Mahmud, Sheikh Zahir Raihan, Nazmul Qais
BACKGROUND: In this ethnopharmacological study, methanolic extract of the aerial plant parts of Phragmites karka (Family: Poaceae) and its petroleum ether and carbon tetrachloride fractions were investigated for bioactivities in Swiss-albino mice, namely, analgesic, central nervous system (CNS) depressant, hypoglycemic, and antidiarrheal activity. METHODS: The cold methanolic extract of the aerial plant parts of Phragmites karka (MEPK) was first prepared, and it was then further fractionated as petroleum ether (PEFMEPK) and carbon tetrachloride (CTFMEPK) fractions...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28063261/isolated-heart-models-for-studying-cardiac-electrophysiology-a-historical-perspective-and-recent-advances
#12
Jie Ming Yeo, Vivian Tse, Judy Kung, Hiu Yu Lin, Yee Ting Lee, Joseph Kwan, Bryan P Yan, Gary Tse
Experimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias...
January 7, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27987363/escitalopram-in-disorder-of-laughter-and-crying-with-predominant-laughter-incontinence
#13
Debadatta Mohapatra, Biswa Ranjan Mishra, Rituparna Maiti, Sudipta Das
No abstract text is available yet for this article.
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27861139/in-vitro-antioxidant-and-anti-inflammatory-activities-of-isolated-compounds-of-ethanol-extract-from-sanchezia-speciosa-leonard-s-leaves
#14
Tung Bui Thanh, Loi Vu Duc, Hai Nguyen Thanh, Vung Nguyen Tien
BACKGROUND: Sanchezia speciosa has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that S. speciosa contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the S. speciosa leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the S. speciosa leaf. METHODS: The leaf of S...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824614/the-effect-of-caffeine-on-energy-balance
#15
Eynav Harpaz, Snait Tamir, Ayelet Weinstein, Yitzhak Weinstein
The global prevalence of obesity has increased considerably in the last two decades. Obesity is caused by an imbalance between energy intake (EI) and energy expenditure (EE), and thus negative energy balance is required to bring about weight loss, which can be achieved by either decreasing EI or increasing EE. Caffeine has been found to influence the energy balance by increasing EE and decreasing EI, therefore, it can potentially be useful as a body weight regulator. Caffeine improves weight maintenance through thermogenesis, fat oxidation, and EI...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824613/methanol-extract-of-nymphaea-lotus-ameliorates-carbon-tetrachloride-induced-chronic-liver-injury-in-rats-via-inhibition-of-oxidative-stress
#16
Ifeoluwa T Oyeyemi, Olubukola O Akanni, Oluwatosin A Adaramoye, Adekunle A Bakare
BACKGROUND: Nymphaea lotus (NL) is an aquatic perennial plant used traditionally in the management of various liver diseases. In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats was investigated. METHODS: Male Wistar rats were assigned into six groups of five rats each. Group I received corn oil (0.5 mL p.o.) and served as control, group II received CCl4 (1 mL/kg i.p., 1:3 in corn oil), group III received NL (200 mg/kg), and groups IV, V, and VI received CCl4+NL (50, 100, and 200 mg/kg, respectively) for 6 weeks...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27701138/the-ameliorating-effect-of-centella-asiatica-ethanolic-extract-on-albino-rats-treated-with-isoniazid
#17
Kavisa Ghosh, N Indra, G Jagadeesan
BACKGROUND: Isoniazid, also called isonicotinyl hydrazine (INH), is a commonly used drug for treating tuberculosis. The main drawback is its toxic side effects. Centella asiatica has long been used in the Ayurvedic system of medicine owing to its wide medicinal properties. This study was designed to examine the effectiveness of C. asiatica ethanolic leaf extract (CA) on INH-treated albino rats. METHODS: The adverse effects induced by INH (50 mg/kg bw) administration on haematological parameters, oxidative status (thiobarbituric acid-reactive substances, superoxide dismutase, catalase, and reduced glutathione), liver and kidney function markers, and their amelioration by various concentrations of CA (20, 40, 60, and 100 mg/kg bw) or silymarin (SIL) (50 mg/kg bw, administered before 1 h of INH treatment for 30 days to rats) were studied...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658143/the-effect-of-aqueous-leaf-extract-of-telfairia-occidentalis-cucurbitaceae-on-gentamycin-induced-renal-damage
#18
Stephen O Maduka, Chidiebere E Ugwu, Oluchi J Onwudinjo
BACKGROUND: Despite the acclaimed beneficial effects of Telfaria occidentalis (TO), it is yet to be established that its aqueous extract is safe in the condition of renal impairment. Thus, the study investigated the effects of TO aqueous leaves extract on gentamycin-induced renal damage. METHODS: The animals were distributed into five groups. Group A (control) was placed on standard rat feed. Groups B and C received 500 mg/kg and 80 mg/kg of TO and gentamicin for 21 days, respectively...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658142/blepharospasm-an-uncommon-adverse-effect-caused-by-long-term-administration-of-olanzapine
#19
Tarun Arora, Vikas Maharshi, Harmeet S Rehan, Pravesh Nagar
BACKGROUND: Blepharospasm is one of the components of drug-induced Meige's syndrome which is reported to be caused by typical antipsychotics. Reports of blepharospasm or Meige's syndrome caused by atypical antipsychotics are rare. CASE: A 30-year-old female patient presented to psychiatry out patient department (OPD) with chief complaints of inability to keep her eyes open for long and excessive blinking for 2 months, irritation of eyes, watery discharge from eyes and photophobia for last 1 month...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658141/comparative-studies-on-the-effects-of-clinically-used-anticonvulsants-on-the-oxidative-stress-biomarkers-in-pentylenetetrazole-induced-kindling-model-of-epileptogenesis-in-mice
#20
Faizan Mazhar, Saima M Malhi, Shabana U Simjee
BACKGROUND: Oxidative stress plays a key role in the pathogenesis of epilepsy and contributes in underlying epileptogenesis process. Anticonvulsant drugs targeting the oxidative stress domain of epileptogenesis may provide better control of seizure. The present study was carried out to investigate the effect of clinically used anti-epileptic drugs (AEDs) on the course of pentylenetetrazole (PTZ)-induced kindling and oxidative stress markers in mice. METHODS: Six mechanistically heterogeneous anticonvulsants: phenobarbital, phenytoin, levetiracetam, pregabalin, topiramate, and felbamate were selected and their redox profiles were determined...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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