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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/28076315/meteorological-parameters-and-pollutants-on-asthma-exacerbation-in-bangalore-india-an-ecological-retrospective-time-series-study
#1
Kirthana U Kunikullaya, Ambarish Vijayaraghava, P Asha, Radhika Kunnavil, B V MuraliMohan
BACKGROUND: Literature has shown a significant association between asthma exacerbations and pollutant levels during that time. There is very limited evidence in India, especially Bangalore, for impacts of meteorological changes and pollution on asthma hospital admissions in adults. The objective was to study the impact of air pollution and meteorological parameters on asthma exacerbation in Bangalore. METHODS: This study quantitatively analyzed the relation between acute exacerbations of asthma and related admissions to the hospital with the air pollution and the meteorological conditions during that time...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076314/in-vivo-sedative-and-hypnotic-activities-of-methanol-extract-from-the-leaves-of-jacquemontia-paniculata-burm-f-hallier-f-in-swiss-albino-mice
#2
Md Jakaria, Chayan Dhar Clinton, Mukimul Islam, Mohammad Belal Talukder, Md Shariful Islam, Syed Mohammed Tareq, Shaikh Bokhtear Uddin
BACKGROUND: The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. METHODS: The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076313/ethnopharmacological-investigation-of-the-aerial-part-of-phragmites-karka-poaceae
#3
Ramiz Ahmed Sultan, Mohammad Shah Hafez Kabir, Mir Muhammad Nasir Uddin, Mohi Uddin, Zobaer Al Mahmud, Sheikh Zahir Raihan, Nazmul Qais
BACKGROUND: In this ethnopharmacological study, methanolic extract of the aerial plant parts of Phragmites karka (Family: Poaceae) and its petroleum ether and carbon tetrachloride fractions were investigated for bioactivities in Swiss-albino mice, namely, analgesic, central nervous system (CNS) depressant, hypoglycemic, and antidiarrheal activity. METHODS: The cold methanolic extract of the aerial plant parts of Phragmites karka (MEPK) was first prepared, and it was then further fractionated as petroleum ether (PEFMEPK) and carbon tetrachloride (CTFMEPK) fractions...
January 11, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28063261/isolated-heart-models-for-studying-cardiac-electrophysiology-a-historical-perspective-and-recent-advances
#4
Jie Ming Yeo, Vivian Tse, Judy Kung, Hiu Yu Lin, Yee Ting Lee, Joseph Kwan, Bryan P Yan, Gary Tse
Experimental models used in cardiovascular research range from cellular to whole heart preparations. Isolated whole hearts show higher levels of structural and functional integration than lower level models such as tissues or cellular fragments. Cardiovascular diseases are multi-factorial problems that are dependent on highly organized structures rather than on molecular or cellular components alone. This article first provides a general introduction on the animal models of cardiovascular diseases. It is followed by a detailed overview and a historical perspective of the different isolated heart systems with a particular focus on the Langendorff perfusion method for the study of cardiac arrhythmias...
January 7, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27861138/bonny-light-crude-oil-induced-alteration-in-levels-of-testicular-stress-proteins-is-accompanied-by-apoptosis-in-rats-after-treatment-withdrawal
#5
Azubuike P Ebokaiwe, Premendu P Mathur, Ebenezer O Farombi
BACKGROUND: The folkloric use of Bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders and as an anti-poison is a generally acceptable practice in the Niger Delta area of Nigeria. The testicular dysfunction induced by BLCO exposure is of public concern with a view to its folkloric usage. The present study investigated the effects of BLCO exposure and withdrawal on the levels of testicular stress proteins and apoptosis-related proteins in rats. METHODS: Adult male Wistar rats were exposed to 800 mg/kg body weight of BLCO for 7 days...
November 18, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27845882/antiplasmodial-activity-of-the-ethanolic-root-bark-extract-of-icacina-senegalensis-in-mice-infected-by-plasmodium-berghei
#6
Godwin C Akuodor, David-Oku Essien, Julie A Nkorroh, Augustine D Essien, Effiong E Nkanor, Mercy N Ezeunala, Kingsley C Chilaka
BACKGROUND: The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria. METHODS: To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used. RESULTS: The root bark extract of I. senegalensis (50, 100, and 200 mg/kg) exhibited a significant (p<0...
November 15, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27831921/the-effects-of-smoking-and-nicotine-ingestion-on-exercise-heat-tolerance
#7
Amit Druayn, Danit Atias, Itay Ketko, Yoav Cohen-Sivan, Yuval Heled
BACKGROUND: Smoking has a thermogenic effect and is associated with low physical performance. Nevertheless, a direct, quantitative effect of acute smoking on exercise heat tolerance has not been reported. METHODS: Sixteen healthy young male volunteers, eight cigarette smokers, and eight non-smokers participated in the study. All subjects performed a maximal oxygen consumption test (VO2max) and a standardized heat tolerance test (HTT) after at least 12 h without smoking under the following conditions: no nicotine exposure, 10 min after nicotine exposure (2 mg nicotine lozenge), and 10 min after smoking two cigarettes (0...
November 10, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824612/effects-of-altered-thyroid-states-on-oxidative-stress-parameters-in-rats
#8
Sehkar Oktay, Lebriz Uslu, Nesrin Emekli
BACKGROUND: Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model. METHODS: Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [L-thyroxine (0...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27815960/evaluation-of-cytotoxic-analgesic-antidiarrheal-and-phytochemical-properties-of-hygrophila-spinosa-t-anders-whole-plant
#9
S M Faysal Bellah, Md Nur Islam, Md Rezaul Karim, Md Masudur Rahaman, Mst Samima Nasrin, Md Atiar Rahman, A S M Ali Reza
BACKGROUND: Synthetic drugs are going to be replaced by plant-derived traditional drugs due to their cost effectiveness, relatively less harmfulness, and efficacy against multidrug resistance organisms. Hygrophila spinosa (Acanthaceae) has been used in a wide range of ailments including flatulence, diarrhea, dysentery, gonorrhea, and menorrhagia. Therefore, we investigated the cytotoxic, antinociceptive, and antidiarrheal effects of H. spinosa ethanol extract (EExHs). METHODS: Preliminary phytochemical screening was accomplished by established methods modified in experimental protocol...
November 5, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27987363/escitalopram-in-disorder-of-laughter-and-crying-with-predominant-laughter-incontinence
#10
Debadatta Mohapatra, Biswa Ranjan Mishra, Rituparna Maiti, Sudipta Das
No abstract text is available yet for this article.
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27861139/in-vitro-antioxidant-and-anti-inflammatory-activities-of-isolated-compounds-of-ethanol-extract-from-sanchezia-speciosa-leonard-s-leaves
#11
Tung Bui Thanh, Loi Vu Duc, Hai Nguyen Thanh, Vung Nguyen Tien
BACKGROUND: Sanchezia speciosa has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that S. speciosa contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the S. speciosa leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the S. speciosa leaf. METHODS: The leaf of S...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824614/the-effect-of-caffeine-on-energy-balance
#12
Eynav Harpaz, Snait Tamir, Ayelet Weinstein, Yitzhak Weinstein
The global prevalence of obesity has increased considerably in the last two decades. Obesity is caused by an imbalance between energy intake (EI) and energy expenditure (EE), and thus negative energy balance is required to bring about weight loss, which can be achieved by either decreasing EI or increasing EE. Caffeine has been found to influence the energy balance by increasing EE and decreasing EI, therefore, it can potentially be useful as a body weight regulator. Caffeine improves weight maintenance through thermogenesis, fat oxidation, and EI...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824613/methanol-extract-of-nymphaea-lotus-ameliorates-carbon-tetrachloride-induced-chronic-liver-injury-in-rats-via-inhibition-of-oxidative-stress
#13
Ifeoluwa T Oyeyemi, Olubukola O Akanni, Oluwatosin A Adaramoye, Adekunle A Bakare
BACKGROUND: Nymphaea lotus (NL) is an aquatic perennial plant used traditionally in the management of various liver diseases. In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats was investigated. METHODS: Male Wistar rats were assigned into six groups of five rats each. Group I received corn oil (0.5 mL p.o.) and served as control, group II received CCl4 (1 mL/kg i.p., 1:3 in corn oil), group III received NL (200 mg/kg), and groups IV, V, and VI received CCl4+NL (50, 100, and 200 mg/kg, respectively) for 6 weeks...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27701138/the-ameliorating-effect-of-centella-asiatica-ethanolic-extract-on-albino-rats-treated-with-isoniazid
#14
Kavisa Ghosh, N Indra, G Jagadeesan
BACKGROUND: Isoniazid, also called isonicotinyl hydrazine (INH), is a commonly used drug for treating tuberculosis. The main drawback is its toxic side effects. Centella asiatica has long been used in the Ayurvedic system of medicine owing to its wide medicinal properties. This study was designed to examine the effectiveness of C. asiatica ethanolic leaf extract (CA) on INH-treated albino rats. METHODS: The adverse effects induced by INH (50 mg/kg bw) administration on haematological parameters, oxidative status (thiobarbituric acid-reactive substances, superoxide dismutase, catalase, and reduced glutathione), liver and kidney function markers, and their amelioration by various concentrations of CA (20, 40, 60, and 100 mg/kg bw) or silymarin (SIL) (50 mg/kg bw, administered before 1 h of INH treatment for 30 days to rats) were studied...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658143/the-effect-of-aqueous-leaf-extract-of-telfairia-occidentalis-cucurbitaceae-on-gentamycin-induced-renal-damage
#15
Stephen O Maduka, Chidiebere E Ugwu, Oluchi J Onwudinjo
BACKGROUND: Despite the acclaimed beneficial effects of Telfaria occidentalis (TO), it is yet to be established that its aqueous extract is safe in the condition of renal impairment. Thus, the study investigated the effects of TO aqueous leaves extract on gentamycin-induced renal damage. METHODS: The animals were distributed into five groups. Group A (control) was placed on standard rat feed. Groups B and C received 500 mg/kg and 80 mg/kg of TO and gentamicin for 21 days, respectively...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658142/blepharospasm-an-uncommon-adverse-effect-caused-by-long-term-administration-of-olanzapine
#16
Tarun Arora, Vikas Maharshi, Harmeet S Rehan, Pravesh Nagar
BACKGROUND: Blepharospasm is one of the components of drug-induced Meige's syndrome which is reported to be caused by typical antipsychotics. Reports of blepharospasm or Meige's syndrome caused by atypical antipsychotics are rare. CASE: A 30-year-old female patient presented to psychiatry out patient department (OPD) with chief complaints of inability to keep her eyes open for long and excessive blinking for 2 months, irritation of eyes, watery discharge from eyes and photophobia for last 1 month...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658141/comparative-studies-on-the-effects-of-clinically-used-anticonvulsants-on-the-oxidative-stress-biomarkers-in-pentylenetetrazole-induced-kindling-model-of-epileptogenesis-in-mice
#17
Faizan Mazhar, Saima M Malhi, Shabana U Simjee
BACKGROUND: Oxidative stress plays a key role in the pathogenesis of epilepsy and contributes in underlying epileptogenesis process. Anticonvulsant drugs targeting the oxidative stress domain of epileptogenesis may provide better control of seizure. The present study was carried out to investigate the effect of clinically used anti-epileptic drugs (AEDs) on the course of pentylenetetrazole (PTZ)-induced kindling and oxidative stress markers in mice. METHODS: Six mechanistically heterogeneous anticonvulsants: phenobarbital, phenytoin, levetiracetam, pregabalin, topiramate, and felbamate were selected and their redox profiles were determined...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658140/ashanti-pepper-piper-guineense-schumach-et-thonn-attenuates-carbohydrate-hydrolyzing-blood-pressure-regulating-and-cholinergic-enzymes-in-experimental-type-2-diabetes-rat-model
#18
Stephen Adeniyi Adefegha, Ganiyu Oboh, Omowunmi Monisola Adefegha
BACKGROUND: Ashanti pepper (Piper guineense Schumach et Thonn) seed is well known in folkloric medicine in the management of type 2 diabetes (T2DM) with little or no scientific documentation for its action. This study investigated the effect of Ashanti pepper seed on some enzymes relevant to carbohydrate hydrolysis, blood regulation and the cholinergic system, as well as the blood glucose level, lipid profile, antioxidant parameters, and hepatic and renal function markers in T2DM rats...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27487493/anti-inflammatory-anti-diarrheal-thrombolytic-and-cytotoxic-activities-of-an-ornamental-medicinal-plant-persicaria-orientalis
#19
Prawej Ansari, Md Josim Uddin, Md Masudur Rahman, Md Abdullah-Al-Mamun, Md Rabiul Islam, Md Hazrat Ali, A S M Ali Reza
BACKGROUND: Persicaria orientalis, an ornamental medicinal plant, has been used in traditional medicine for the treatment of various diseases. Although the plant is reported to have some important pharmacological effects, many medicinal values remain unidentified. Our objective was to evaluate the anti-inflammatory, anti-diarrheal, thrombolytic, and cytotoxic properties of the methanol extract of P. orientalis leaves (Po-MeOH). METHODS: Anti-inflammatory activity was measured by the inhibition of hypotonicity-induced human red blood cell hemolysis and albumin denaturation technique in vitro of Po-MeOH...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27487492/comparative-pre-emptive-analgesic-efficacy-study-of-novel-antiepileptic-agents-gabapentin-lamotrigine-and-topiramate-in-patients-undergoing-major-surgeries-at-a-tertiary-care-hospital-a-randomized-double-blind-clinical-trial
#20
Uma A Bhosale, Radha Yegnanarayan, Ankush Gupta, Priyank Shah, Shalini Sardesai
BACKGROUND: Surgical injury leads to postoperative pain hypersensitivity preceded by central nervous sensitization, due to lowered pain threshold in peripheral nociceptors and increased excitability of the spinal neurons. Pre-emptive analgesia is intended to decrease pain perception and overall analgesic need by use of drug regimen seizing central nervous system sensitization before exposure to painful stimuli. Earlier, few studies support pre-emptive analgesic efficacy of novel antiepileptic agent gabapentin...
January 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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