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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/27861139/in-vitro-antioxidant-and-anti-inflammatory-activities-of-isolated-compounds-of-ethanol-extract-from-sanchezia-speciosa-leonard-s-leaves
#1
Tung Bui Thanh, Loi Vu Duc, Hai Nguyen Thanh, Vung Nguyen Tien
BACKGROUND: Sanchezia speciosa has been used in traditional medicine for gastritis treatment in Vietnam. Some phytochemical study showed that S. speciosa contains high amounts of flavonoids and cardiac glycoside compounds. In the present study, we isolated four compounds from the ethanol extract of the S. speciosa leaf, and we evaluated the in vitro antioxidant and anti-inflammatory effect of the isolated compound from the ethanol extract of the S. speciosa leaf. METHODS: The leaf of S...
November 18, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27861138/bonny-light-crude-oil-induced-alteration-in-levels-of-testicular-stress-proteins-is-accompanied-by-apoptosis-in-rats-after-treatment-withdrawal
#2
Azubuike P Ebokaiwe, Premendu P Mathur, Ebenezer O Farombi
BACKGROUND: The folkloric use of Bonny light crude oil (BLCO) in the treatment of gastrointestinal disorders and as an anti-poison is a generally acceptable practice in the Niger Delta area of Nigeria. The testicular dysfunction induced by BLCO exposure is of public concern with a view to its folkloric usage. The present study investigated the effects of BLCO exposure and withdrawal on the levels of testicular stress proteins and apoptosis-related proteins in rats. METHODS: Adult male Wistar rats were exposed to 800 mg/kg body weight of BLCO for 7 days...
November 18, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27845882/antiplasmodial-activity-of-the-ethanolic-root-bark-extract-of-icacina-senegalensis-in-mice-infected-by-plasmodium-berghei
#3
Godwin C Akuodor, David-Oku Essien, Julie A Nkorroh, Augustine D Essien, Effiong E Nkanor, Mercy N Ezeunala, Kingsley C Chilaka
BACKGROUND: The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria. METHODS: To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used. RESULTS: The root bark extract of I. senegalensis (50, 100, and 200 mg/kg) exhibited a significant (p<0...
November 15, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27831921/the-effects-of-smoking-and-nicotine-ingestion-on-exercise-heat-tolerance
#4
Amit Druayn, Danit Atias, Itay Ketko, Yoav Cohen-Sivan, Yuval Heled
BACKGROUND: Smoking has a thermogenic effect and is associated with low physical performance. Nevertheless, a direct, quantitative effect of acute smoking on exercise heat tolerance has not been reported. METHODS: Sixteen healthy young male volunteers, eight cigarette smokers, and eight non-smokers participated in the study. All subjects performed a maximal oxygen consumption test (VO2max) and a standardized heat tolerance test (HTT) after at least 12 h without smoking under the following conditions: no nicotine exposure, 10 min after nicotine exposure (2 mg nicotine lozenge), and 10 min after smoking two cigarettes (0...
November 10, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824614/the-effect-of-caffeine-on-energy-balance
#5
Eynav Harpaz, Snait Tamir, Ayelet Weinstein, Yitzhak Weinstein
The global prevalence of obesity has increased considerably in the last two decades. Obesity is caused by an imbalance between energy intake (EI) and energy expenditure (EE), and thus negative energy balance is required to bring about weight loss, which can be achieved by either decreasing EI or increasing EE. Caffeine has been found to influence the energy balance by increasing EE and decreasing EI, therefore, it can potentially be useful as a body weight regulator. Caffeine improves weight maintenance through thermogenesis, fat oxidation, and EI...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824613/methanol-extract-of-nymphaea-lotus-ameliorates-carbon-tetrachloride-induced-chronic-liver-injury-in-rats-via-inhibition-of-oxidative-stress
#6
Ifeoluwa T Oyeyemi, Olubukola O Akanni, Oluwatosin A Adaramoye, Adekunle A Bakare
BACKGROUND: Nymphaea lotus (NL) is an aquatic perennial plant used traditionally in the management of various liver diseases. In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats was investigated. METHODS: Male Wistar rats were assigned into six groups of five rats each. Group I received corn oil (0.5 mL p.o.) and served as control, group II received CCl4 (1 mL/kg i.p., 1:3 in corn oil), group III received NL (200 mg/kg), and groups IV, V, and VI received CCl4+NL (50, 100, and 200 mg/kg, respectively) for 6 weeks...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27824612/effects-of-altered-thyroid-states-on-oxidative-stress-parameters-in-rats
#7
Sehkar Oktay, Lebriz Uslu, Nesrin Emekli
BACKGROUND: Thyroid hormones are effective on oxidant-antioxidant balance by leading basal metabolic rate. In this study, the effects of altered thyroid states on low density lipoprotein (LDL) oxidation and oxidative stress parameters were investigated in an experimental animal model. METHODS: Thirty female Wistar Albino rats were equally divided into 3 groups as follows: control group; hypothyroid group (methimazole (75 mg/100 g was added to diet); hyperthyroid group [L-thyroxine (0...
November 8, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27815960/evaluation-of-cytotoxic-analgesic-antidiarrheal-and-phytochemical-properties-of-hygrophila-spinosa-t-anders-whole-plant
#8
S M Faysal Bellah, Md Nur Islam, Md Rezaul Karim, Md Masudur Rahaman, Mst Samima Nasrin, Md Atiar Rahman, A S M Ali Reza
BACKGROUND: Synthetic drugs are going to be replaced by plant-derived traditional drugs due to their cost effectiveness, relatively less harmfulness, and efficacy against multidrug resistance organisms. Hygrophila spinosa (Acanthaceae) has been used in a wide range of ailments including flatulence, diarrhea, dysentery, gonorrhea, and menorrhagia. Therefore, we investigated the cytotoxic, antinociceptive, and antidiarrheal effects of H. spinosa ethanol extract (EExHs). METHODS: Preliminary phytochemical screening was accomplished by established methods modified in experimental protocol...
November 5, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27701138/the-ameliorating-effect-of-centella-asiatica-ethanolic-extract-on-albino-rats-treated-with-isoniazid
#9
Kavisa Ghosh, N Indra, G Jagadeesan
BACKGROUND: Isoniazid, also called isonicotinyl hydrazine (INH), is a commonly used drug for treating tuberculosis. The main drawback is its toxic side effects. Centella asiatica has long been used in the Ayurvedic system of medicine owing to its wide medicinal properties. This study was designed to examine the effectiveness of C. asiatica ethanolic leaf extract (CA) on INH-treated albino rats. METHODS: The adverse effects induced by INH (50 mg/kg bw) administration on haematological parameters, oxidative status (thiobarbituric acid-reactive substances, superoxide dismutase, catalase, and reduced glutathione), liver and kidney function markers, and their amelioration by various concentrations of CA (20, 40, 60, and 100 mg/kg bw) or silymarin (SIL) (50 mg/kg bw, administered before 1 h of INH treatment for 30 days to rats) were studied...
October 4, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27701137/oxidative-stress-histopathological-and-electron-microscopic-alterations-induced-by-dimethylnitrosamine-in-renal-male-mice-and-the-protective-effect-of-%C3%AE-lipoic-acid
#10
Reham Z Hamza, Hayat A A Ismail, Nahla S El-Shenawy
BACKGROUND: Dimethylnitrosamine (DMN) is a waste product of several industrial processes. Alpha-lipoic acid (ALA) is a vitamin-like chemical also called as an antioxidant. Therefore, the study was designed to investigate the potential benefits of ALA in reducing the nephropathy of DMN in male mice. METHODS: Animals were divided into 6 groups (n=8) and received their treatment for 4 weeks as follows: groups 1-4 served as control, ALA-treatment (16.12 mg/kg), DMN low dose treatment and DMN high dose treatment, respectively...
October 4, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27665420/exercise-increases-the-level-of-plasma-orexin-a-in-humans
#11
Giovanni Messina, Giovanni Di Bernardo, Andrea Viggiano, Vincenzo De Luca, Vincenzo Monda, Antonietta Messina, Sergio Chieffi, Umberto Galderisi, Marcellino Monda
BACKGROUND: The purpose of this research was to study the effects of exercise on the concentration of plasma orexin A, a peptide regulating several physiological functions. METHODS: Blood samples were collected from participants (men, n=10; age: 24.4±2.93 years) 15, 0 min before the start of exercise, and 30, 45, 60 min after a cycle ergometer exercise at 75 W for 15 min. Also heart rate (HR), galvanic skin response (GSR), and rectal temperature were monitored...
September 26, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27664773/neuropharmacological-evaluation-of-a-novel-5-ht3-receptor-antagonist-4-benzylpiperazin-1-yl-3-methoxyquinoxalin-2-yl-methanone-6g-on-lipopolysaccharide-induced-anxiety-models-in-mice
#12
Shvetank Bhatt, Radhakrishnan Mahesh, Thangaraj Devadoss, Ankur Jindal
BACKGROUND: 5-HT3 receptor antagonists play a key role in the management of psychiatric disorders such as, depression and anxiety. They may act through modulation of serotonergic transmission. In the present study, a novel and potential 5-HT3 receptor antagonist, 6g (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl) methanone, which exhibited good log P (3.08) and pA2 (7.5) values was screened for its anxiolytic property in lipopolysaccharide (LPS) induced anxiety models. METHODS: LPS, an endotoxin, present in the cell wall of Gram negative bacteria was injected 0...
September 24, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27662644/neuropharmacological-and-neurochemical-evaluation-of-n-n-propyl-3-ethoxyquinoxaline-2-carboxamide-6n-a-novel-serotonergic-5-ht3-receptor-antagonist-for-co-morbid-antidepressant-and-anxiolytic-like-potential-using-traumatic-brain-injury-model-in-rats
#13
Shvetank Bhatt, Radhakrishnan Mahesh, Ankur Jindal, Thangaraj Devadoss
BACKGROUND: Several preclinical studies have shown that serotonergic 5-HT3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. In the present study the compound "6n" (N-n-propyl-3-ethoxyquinoxaline-2-carboxamide), a novel 5-HT3 receptor antagonist with an optimal log P (2.52) and pA2 (7.6) value was screened for its neuro-pharmacological potential in chronic rodent models of depression and anxiety named traumatic brain injury (TBI)...
September 23, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658143/the-effect-of-aqueous-leaf-extract-of-telfairia-occidentalis-cucurbitaceae-on-gentamycin-induced-renal-damage
#14
Stephen O Maduka, Chidiebere E Ugwu, Oluchi J Onwudinjo
BACKGROUND: Despite the acclaimed beneficial effects of Telfaria occidentalis (TO), it is yet to be established that its aqueous extract is safe in the condition of renal impairment. Thus, the study investigated the effects of TO aqueous leaves extract on gentamycin-induced renal damage. METHODS: The animals were distributed into five groups. Group A (control) was placed on standard rat feed. Groups B and C received 500 mg/kg and 80 mg/kg of TO and gentamicin for 21 days, respectively...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658142/blepharospasm-an-uncommon-adverse-effect-caused-by-long-term-administration-of-olanzapine
#15
Tarun Arora, Vikas Maharshi, Harmeet S Rehan, Pravesh Nagar
BACKGROUND: Blepharospasm is one of the components of drug-induced Meige's syndrome which is reported to be caused by typical antipsychotics. Reports of blepharospasm or Meige's syndrome caused by atypical antipsychotics are rare. CASE: A 30-year-old female patient presented to psychiatry out patient department (OPD) with chief complaints of inability to keep her eyes open for long and excessive blinking for 2 months, irritation of eyes, watery discharge from eyes and photophobia for last 1 month...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658141/comparative-studies-on-the-effects-of-clinically-used-anticonvulsants-on-the-oxidative-stress-biomarkers-in-pentylenetetrazole-induced-kindling-model-of-epileptogenesis-in-mice
#16
Faizan Mazhar, Saima M Malhi, Shabana U Simjee
BACKGROUND: Oxidative stress plays a key role in the pathogenesis of epilepsy and contributes in underlying epileptogenesis process. Anticonvulsant drugs targeting the oxidative stress domain of epileptogenesis may provide better control of seizure. The present study was carried out to investigate the effect of clinically used anti-epileptic drugs (AEDs) on the course of pentylenetetrazole (PTZ)-induced kindling and oxidative stress markers in mice. METHODS: Six mechanistically heterogeneous anticonvulsants: phenobarbital, phenytoin, levetiracetam, pregabalin, topiramate, and felbamate were selected and their redox profiles were determined...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658140/ashanti-pepper-piper-guineense-schumach-et-thonn-attenuates-carbohydrate-hydrolyzing-blood-pressure-regulating-and-cholinergic-enzymes-in-experimental-type-2-diabetes-rat-model
#17
Stephen Adeniyi Adefegha, Ganiyu Oboh, Omowunmi Monisola Adefegha
BACKGROUND: Ashanti pepper (Piper guineense Schumach et Thonn) seed is well known in folkloric medicine in the management of type 2 diabetes (T2DM) with little or no scientific documentation for its action. This study investigated the effect of Ashanti pepper seed on some enzymes relevant to carbohydrate hydrolysis, blood regulation and the cholinergic system, as well as the blood glucose level, lipid profile, antioxidant parameters, and hepatic and renal function markers in T2DM rats...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658139/%C3%AE-lipoic-acid-attenuates-transplacental-nicotine-induced-germ-cell-and-oxidative-dna-damage-in-adult-mice
#18
Santo K Anto, Naresh Koyada, Sabbir Khan, Gopabandhu Jena
BACKGROUND: Smoking during pregnancy is associated with numerous fetal and developmental complications and reproductive dysfunctions in the offspring. Nicotine is one of the key chemicals of tobacco responsible for addiction. The present study was aimed to investigate the protective role of α-lipoic acid (ALA) during the transplacental nicotine-induced germ cell and DNA damage in the offspring of Swiss mice. METHODS: Pregnant mice were treated with nicotine (20 mg/kg/day) in drinking water from 10 to 20 days of gestation period, and ALA (120 mg/kg/day) was administered orally for the same period...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27658138/antioxidant-and-acetylcholinesterase-inhibitory-activities-of-leaf-extract-and-fractions-of-albizia-adianthifolia-schumach-w-f-wright
#19
Mubo A Sonibare, Ibukun O Ayoola, Taiwo O Elufioye
BACKGROUND: This study was conducted to determine the antioxidant and acetylcholinesterase inhibitory activities of the leaf extract and different fractions of Albizia adianthifolia (Schumach.) W. Wright, and also to identify and quantify some phenolic compounds in the extract. METHODS: The antioxidant and acetylcholinesterase inhibitory activities of the methanol extract (CME), ethyl acetate (EAF), chloroform (CHF), and n-hexane (NHF) fractions of A. adianthifolia leaves were subjected to in vitro chemical analyses...
September 22, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27508960/comparison-of-fluoxetine-and-1-methyl-l-tryptophan-in-treatment-of-depression-like-illness-in-bacillus-calmette-guerin-induced-inflammatory-model-of-depression-in-mice
#20
Proteesh Rana, Amit K Sharma, Smita Jain, Pravin Deshmukh, S K Bhattacharya, B D Banerjee, Pramod K Mediratta
BACKGROUND: The inflammatory response system has been implicated in the pathophysiology of major depression. The pro-inflammatory cytokines like interferon-γ induce the enzyme indoleamine-2,3-dioxygenase (IDO) of the kynurenine pathway of tryptophan metabolism. The induction of IDO reduces the availability of tryptophan for serotonin synthesis. Furthermore, the metabolites of kynurenine pathway have neurotoxic property, which along with decreased serotonin may account for depression-like illness...
November 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
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