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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/28375845/effect-of-adrenocorticotropic-hormone-on-ucp1-gene-expression-in-brown-adipocytes
#1
Hirendra M Biswas
BACKGROUND: Like other tissues, adrenocorticotropic hormone (ACTH) can produce its effect on brown adipose tissue (BAT). This study was taken to understand the direct effect of ACTH action on thermogenin gene expression and possible relation with α receptors and caffeine with this hormone. METHODS: Brown fat precursor cells were isolated from interscapular BAT of young mice and grown in culture. The cells were exposed to norepinephrine (NE) and other agents. Total RNA was isolated after harvesting the cells, and northern blot analysis was performed...
April 4, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28358713/the-effect-of-extracellular-atp-on-rat-uterine-contraction-from-different-gestational-stages-and-its-possible-mechanisms-of-action
#2
Hind A Zafrah, Mohammed F Alotaibi
BACKGROUND: The mechanisms underlying the onset of labor are not fully understood. Extracellular adenosine 5'-triphosphate (ATP) is known to cause uterine contractions in different species but the exact underlying mechanisms are poorly investigated to date. The aims of this study were to investigate the effect of extracellular ATP on spontaneous uterine contractions from different gestational stages and to elucidate its possible underlying mechanisms. METHODS: Longitudinal uterine strips were obtained from rats in different gestational stages (nonpregnant, late-pregnant, and term-pregnant)...
March 30, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28358712/anti-inflammatory-activity-of-elaeagnus-angustifolia-fruit-extract-on-rat-paw-edema
#3
Manijeh Motevalian, Mehdi Shiri, Saeedeh Shiri, Zahra Shiri, Hadi Shiri
BACKGROUND: The Elaeagnus angustifolia fruit has been traditionally used in Iranian herbal medicine to treat diarrhea and rheumatoid arthritis. In the present study, the effects of E. angustifolia fruit extract on the acute and chronic phases of formalin-induced rat paw edema were examined. MATERIALS AND METHODS: The acute and chronic anti-inflammatory effects of E. angustifolia fruit extract were investigated through the subcutaneous injection of 100 μL of formalin (2...
March 30, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28355145/histopathological-and-biochemical-assessments-of-costus-afer-stem-on-alloxan-induced-diabetic-rats
#4
Anthoneth Ndidi Ezejiofor, Zelinjo Nkeiruka Igweze, Nnaemeka Arinze Udowelle, Orish Ebere Orisakwe
BACKGROUND: In continuation of our study of the biological activity of the aqueous extract of Costus afer stem used in tradomedicare in Nigeria, this work has investigated the biochemical, nephroprotective, hepatoprotective and protective effects of aqueous extract of C. afer stem on alloxan-induced hyperglycaemic albino Wistar rats. METHODS: Thirty male albino Wistar rats (150-200 g) were weight-matched into six groups of five rats each. Groups 1 and 2 were the normal (non-induced) and toxic (alloxan-induced) controls, respectively...
March 29, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350537/comparison-of-structured-and-unstructured-physical-activity-training-on-predicted-vo2max-and-heart-rate-variability-in-adolescents-a-randomized-control-trial
#5
Vivek Kumar Sharma, Senthil Kumar Subramanian, Krishnakumar Radhakrishnan, Rajathi Rajendran, Balasubramanian Sulur Ravindran, Vinayathan Arunachalam
BACKGROUND: Physical inactivity contributes to many health issues. The WHO-recommended physical activity for adolescents encompasses aerobic, resistance, and bone strengthening exercises aimed at achieving health-related physical fitness. Heart rate variability (HRV) and maximal aerobic capacity (VO2max) are considered as noninvasive measures of cardiovascular health. The objective of this study is to compare the effect of structured and unstructured physical training on maximal aerobic capacity and HRV among adolescents...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350536/anti-inflammatory-effects-and-anti-oxidant-capacity-of-myrathius-arboreus-cecropiaceae-in-experimental-models
#6
Oluwafemi Gabriel Oluwole, Olufunmilayo Ologe, Akinyinka Alabi, Ganiyu Tunde Yusuf, Solomon Umukoro
BACKGROUND: Inflammation is involved in various diseases; search for safe treatments is warranted. Anti-inflammatory effects of ethanol extract of Myrathius arboreus (EEMa) were studied in carrageenan-induced model, formaldehyde sub-acute-induced model, and in 48 h lipopolysaccharide-induced air pouch model of inflammation. EEMa membrane-stabilizing activities and anti-oxidant capacity were determined in vitro. METHODS: In the carrageenan model EEMa (125, 250, or 500 mg/kg), indomethacin (5 mg/kg), or vehicle 3 mL/kg was administered orally in rats (n=5)...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28328528/ocimum-gratissimum-linn-leaf-extract-inhibits-free-radical-generation-and-suppressed-inflammation-in-carrageenan-induced-inflammation-models-in-rats
#7
Abayomi M Ajayi, Mary O Ologe, Benneth Ben-Azu, Samuel E Okhale, Bulus Adzu, Olusegun G Ademowo
BACKGROUND: Ocimum gratissimum leaf is used in managing rheumatism and other inflammatory conditions. In this study, we investigated the antioxidant and anti-inflammatory effects of phenolic extract obtained by sequential methanol extraction of O. gratissimum leaves (MEOg). METHODS: The methanol extract (MEOg) was obtained after sequential maceration (n-hexane, chloroform and methanol) of dried O. gratissimum leaves. The fingerprint of the extract was obtained using a high-performance liquid chromatrographic method...
March 22, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28315847/effects-of-peripherally-and-centrally-applied-ghrelin-on-the-oxidative-stress-induced-by-renin-angiotensin-system-in-a-rat-model-of-renovascular-hypertension
#8
Vivian Boshra, Amr M Abbas
BACKGROUND: Renovascular hypertension (RVH) is a result of renal artery stenosis, which is commonly due to astherosclerosis. In this study, we aimed to clarify the central and peripheral effects of ghrelin on the renin-angiotensin system (RAS) in a rat model of RVH. METHODS: RVH was induced in rats by partial subdiaphragmatic aortic constriction. Experiment A was designed to assess the central effect of ghrelin via the intracerebroventricular (ICV) injection of ghrelin (5 μg/kg) or losartan (0...
March 20, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306530/ascorbic-acid-does-not-modulate-potassium-currents-in-cultured-human-lymphocytes
#9
Saravanakumar Snekalatha, Praghalathan Kanthakumar
BACKGROUND: Ascorbic acid (AA) is known to modulate lymphocyte function, but the mechanism of action is not clearly understood. As voltage-gated potassium currents play an important role in lymphocyte function, the effect of AA on voltage-gated potassium currents was studied. METHODS: Peripheral blood mononuclear cells were cultured in the presence of increasing concentrations of AA (0, 0.125, 0.25, 0.5, and 1 mM). Potassium currents in resting lymphocytes were studied by whole cell patch clamp technique using a depolarizing protocol...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306529/in-vitro-inhibition-of-phosphodiesterase-5-and-arginase-activities-from-rat-penile-tissue-by-two-nigerian-herbs-hunteria-umbellata-and-anogeissus-leiocarpus
#10
Ganiyu Oboh, Adeniyi Abiodun Adebayo, Ayokunle Olubode Ademosun, Aline August Boligon
BACKGROUND: Anogeissus leiocarpus and Hunteria umbellata have been reportedly used in traditional medicine for the management of erectile dysfunction (ED). However, the scientific basis for their use has not been well established. Therefore, this study was designed to investigate the inhibitory effects of water extractable phytochemicals of H. umbellata and A. leiocarpus on phosphodiesterase-5 (PDE-5) and arginase as well as pro-oxidants induced lipid peroxidation in rat penile tissue...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306527/investigation-of-the-role-of-%C3%AE-lipoic-acid-on-fatty-acids-profile-some-minerals-zinc-copper-iron-and-antioxidant-activity-against-aluminum-induced-oxidative-stress-in-the-liver-of-male-rats
#11
Zafer Sahin, Ahmet Ozkaya, Okkes Yilmaz, Abdurrauf Yuce, Mehmet Gunes
BACKGROUND: We have investigated the effects of α-lipoic acid (LA), a powerful antioxidant, on the fatty acid (FA) profiles, aluminum accumulation, antioxidant activity and some minerals such as zinc, copper and iron against aluminum chloride (AlCl3)-induced oxidative stress in rat liver. METHODS: Twenty-eight male Wistar rats were divided into four groups as control, LA, AlCl3 and LA+AlCl3. For 30 days, LA was intraperitoneally administrated (50 mg/kg) and AlCl3 was given via orogastric gavage (1600 ppm) every other day...
March 17, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28306528/protective-effect-of-moringa-oleifera-oil-against-hgcl2-induced-hepato-and-nephro-toxicity-in-rats
#12
Sunny O Abarikwu, Sussan Benjamin, Sunday Godspower Ebah, Godbless Obilor, Goodluck Agbam
BACKGROUND: Various parts of the Moringa oleifera (M. oleifera) tree are widely accepted to have ameliorative effects against metal toxicity. In the present study, M. oleifeira oil (MO) was tested against HgCl2-induced tissue pathologies and oxidative stress. METHODS: Male Wistar rats were administered MO (1.798 mg/kg p.o.) or HgCl2 (5 mg/kg body wt) alone or in combination (5 mg/kg HgCl2+1.798 mg/kg MO p.o.) three times per week for 21 days. After exposure and treatment periods, rats were sacrificed; blood collected and the oxidative status of the liver and kidney homogenates were evaluated...
March 15, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28222030/sub-chronic-indomethacin-treatment-and-its-effect-on-the-male-reproductive-system-of-albino-rats-possible-protective-role-of-black-tea-extract
#13
Ishwar B Bagoji, Gavishiddappa A Hadimani, Saeed M Yendigeri, Kusal K Das
BACKGROUND: Indomethacin is commonly used as a nonsteroidal anti-inflammatory drug (NSAID) to treat inflammation, arthritis and joint pains. Unfortunately, it has a wide range of adverse effects on the physiological system, including gonads. This study aimed to assess possible beneficial effects of black tea extract (BTE) against indomethacin-induced alteration of gonadal hormone levels in male rats. MATERIALS AND METHODS: Adult male rats were divided into Group I (control), Group II (indomethacin, 5 mg/kg body weight [bwt...
February 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28222029/effect-of-cardiovascular-and-muscular-endurance-is-not-associated-with-stress-fracture-incidence-in-female-military-recruits-a-12-month-follow-up-study
#14
Mickey Scheinowitz, Ran Yanovich, Nurit Sharvit, Michal Arnon, Daniel S Moran
BACKGROUND: Stress fracture (SF) is a common injury among military recruits, especially among women, during the army basic training (ABT). The purpose of this study was to evaluate the effects of health habits and physical activity before recruitment on the fitness level and the incidence of SF during the 4-month ABT. MATERIALS AND METHODS: We screened 226 female recruit volunteers (weight: 60.5±10 kg; height: 163±6 cm) from an integrated combat unit and 124 aged-matched female controls (weight: 57...
February 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28207414/anti-aging-effects-of-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-immunosuppressive-drug-on-the-enzymatic-and-non-enzymatic-oxidative-stress-parameters-in-an-experimental-model
#15
Soma Hosseini, Mohammad Abdollahi, Gholamreza Azizi, Mohammad Javad Fattahi, Noshin Rastkari, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Abbas Mirshafiey
BACKGROUND: The anti-aging property of β-D-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory and immunosuppressive agent was investigated on several determinants relative to the oxidative stress in an animal model. MATERIALS AND METHODS: Sprague-Dawley rats were used for evaluating the safety and efficacy properties of M2000 on some oxidative stress enzymes, including the following: mitochondrial superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX1), glutathione S-transferase (GST), myeloperoxidase (MPO), and inducible nitric oxide synthase (iNOS) gene expression by real-time PCR...
February 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28284033/antidepressant-and-anxiolytic-like-sedation-and-hypnosis
#16
Michal Horowitz
No abstract text is available yet for this article.
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28132032/effect-of-salacia-reticulata-w-and-clitoria-ternatea-l-on-the-cognitive-and-behavioral-changes-in-the-streptozotocin-induced-young-diabetic-rats
#17
R Rajashree, Rajani Patil, Sanjiva D Khlokute, Shivaprasad S Goudar
BACKGROUND: Diabetes mellitus (DM) of juvenile onset affects both the peripheral and central nervous systems (CNS). However, central effects are less documented and studied than peripheral deficits. Currently, the only feasible treatment available for type 1 DM (T1DM) is insulin which has its own limitations. Hence, an alternative therapy, especially a newer herbal formulation is very much the need of the time. The present study aimed to determine the effects of the alcoholic extracts of roots of the Salacia reticulata W...
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28121616/investigation-of-antinociceptive-activity-of-methanolic-extract-of-persicaria-orientalis-leaves-in-rodents
#18
Prawej Ansari, Md Josim Uddin, Shafia Akther, Shofiul Azam, Md Kayes Mahmud, Sohel Bin Azad, Ahsan Ullah, J M A Hannan
BACKGROUND: This study aims to evaluate the scientific basis of traditional application of Persicaria orientalis for reducing pain and inflammation. METHODS: An in vitro method was performed to investigate the presence of the anti-inflammatory activity of methanolic crude extract of P. orientalis. In addition, an in vivo study was conducted in which the hot-plate and tail immersion methods were applied to explore the acute effect of P. orientalis on analgesia. The potency to inhibit chronic inflammation in mice was justified by the carrageenan-induced paw edema and formalin-induced edema methods...
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076315/meteorological-parameters-and-pollutants-on-asthma-exacerbation-in-bangalore-india-an-ecological-retrospective-time-series-study
#19
Kirthana U Kunikullaya, Ambarish Vijayaraghava, P Asha, Radhika Kunnavil, B V MuraliMohan
BACKGROUND: Literature has shown a significant association between asthma exacerbations and pollutant levels during that time. There is very limited evidence in India, especially Bangalore, for impacts of meteorological changes and pollution on asthma hospital admissions in adults. The objective was to study the impact of air pollution and meteorological parameters on asthma exacerbation in Bangalore. METHODS: This study quantitatively analyzed the relation between acute exacerbations of asthma and related admissions to the hospital with the air pollution and the meteorological conditions during that time...
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28076314/in-vivo-sedative-and-hypnotic-activities-of-methanol-extract-from-the-leaves-of-jacquemontia-paniculata-burm-f-hallier-f-in-swiss-albino-mice
#20
Md Jakaria, Chayan Dhar Clinton, Mukimul Islam, Mohammad Belal Talukder, Md Shariful Islam, Syed Mohammed Tareq, Shaikh Bokhtear Uddin
BACKGROUND: The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. METHODS: The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg...
March 1, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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