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Journal of Basic and Clinical Physiology and Pharmacology

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https://www.readbyqxmd.com/read/30332394/sympathovagal-imbalance-and-neurophysiologic-cognitive-assessment-using-evoked-potentials-in-polycystic-ovary-syndrome-in-young-adolescents-a-cross-sectional-study
#1
Deepika Velusami, Sivaranjini Sivasubramanian
Background Altered lifestyle and urbanization have potentially increased the prevalence of polycystic ovary syndrome (PCOS) among the women in India. The aim of the present study was to evaluate the autonomic function and subclinical cognition impairment using evoked potentials in PCOS-affected young adolescents. Methods This was a cross-sectional study, approved by Indian Medical of Council Research as a short-term student project. The study was performed with adolescent girls (age group, 10-18 years) diagnosed as having PCOS, attending the Department of Obstetrics and Gynecology at Sri Manakula Vinayagar Medical College and Hospital, Puducherry...
October 17, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30332393/dynamics-of-inflammatory-reaction-and-oxidative-stress-across-maternal-serum-placenta-and-amniotic-fluid-in-laboratory-rats-and-the-role-played-by-genistein-aglycone
#2
Funmileyi O Awobajo, Ayodele O Morakinyo, Titilola A Samuel, Oluwakemi T Oyelowo, Abimbola O Ogunsola, Perpetual U Onyekwele, Mosunmola E Okedina, Oluwadamilola O Ogunbanwo
Background Genistein was reported to adversely influence fetal development although this is yet to be fully understood as a mechanism. Methods In this study, pregnant rats were divided into control (Cont.) and genistein force-fed (2-mg/kg and 4-mg/kg) groups. Each group was divided further into five subgroups: GD-0, GD-6, GD-13, GD-18, and GD-20 based on the terminal gestational day (GD). On the respective terminal GD, the rats were sacrificed and blood samples and amniotic fluid were carefully collected and separated and placenta homogenates were prepared...
October 17, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30332392/antinociceptive-and-anti-inflammatory-properties-of-tetracera-alnifolia-willd-dilleniaceae-hydroethanolic-leaf-extract
#3
Olufunmilayo O Adeyemi, Ismail O Ishola, Elizabeth T Adesanya, Destiny O Alohan
Background Tetracera alnifolia Willd. (Dilleniaceae) is used in traditional African Medicine for the treatment of headache, abdominal pain, and rheumatism. Hence, this study sought to investigate the antinociceptive and anti-inflammatory effects of the hydroethanolic leaf extract of T. alnifolia (HeTA) in rodents. Methods Antinociceptive activity was evaluated using the acetic acid-induced writhing, formalin-/capsaicin-induced paw licking and hot plate tests in mice. The contribution of opioidergic, l-arginine-nitric oxide, and ATP-sensitive potassium channel pathways in HeTA-induced antinociception was also evaluated...
October 17, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30281514/review-of-thiamine-deficiency-disorders-wernicke-encephalopathy-and-korsakoff-psychosis
#4
Abin Chandrakumar, Aseem Bhardwaj, Geert W 't Jong
Wernicke encephalopathy (WE) and Korsakoff psychosis (KP), together termed Wernicke-Korsakoff syndrome (WKS), are distinct yet overlapping neuropsychiatric disorders associated with thiamine deficiency. Thiamine pyrophosphate, the biologically active form of thiamine, is essential for multiple biochemical pathways involved in carbohydrate utilization. Both genetic susceptibilities and acquired deficiencies as a result of alcoholic and non-alcoholic factors are associated with thiamine deficiency or its impaired utilization...
October 2, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30269105/the-standardized-extract-of-nigella-sativa-and-its-major-ingredient-thymoquinone-ameliorates-angiotensin-ii-induced-hypertension-in-rats
#5
Lili Enayatfard, Reza Mohebbati, Saeed Niazmand, Mahmoud Hosseini, Mohammad Naser Shafei
Background This study investigated the effect of hydroalcoholic extract of Nigella sativa (N. sativa) and its active component, thymoquinone (TQ) on hypertension induced by angiotensin II (AngII), the main product of renin-angiotensin system (RAS). Methods Seven animal groups (n=7 for each group) were used as follows: (1) control, (2) AngII (300 ng/kg), (3) AngII+losartan (Los; 10 mg/kg), (4) TQ (40 mg/kg)+AngII, and (5-7) three doses of N. sativa (200, 400, and 600 mg/kg)+AngII. Los and AngII were injected intravenously; TQ and extracts were injected intraperitoneally...
October 1, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30265651/correlation-between-the-blood-level-of-irisin-and-the-severity-of-acute-myocardial-infarction-in-exercise-trained-rats
#6
Shaimaa M Bashar, Shereen M Samir El-Sherbeiny, Mohamed Z Boraie
Background Acute myocardial infarction is a major cause of death all over the world. Irisin is a novel myokine released after exercise. This work aimed to study the correlation between the serum irisin level and the severity of the acute myocardial infarction in the exercise-trained rats. Methods Forty-eight male rats were classified into four groups (12 for each): group I, control sedentary (C); group II, exercise-trained (EX) (swimming for 8 weeks); group III, isoprenaline-induced infarct (MI); and group IV, exercise-trained infarct (EX-MI) (swimming for 8 weeks followed by isoprenaline-induced infarction)...
September 28, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30260792/current-insights-and-future-perspectives-of-hypoxia-inducible-factor-targeted-therapy-in-cancer
#7
Thekkuttuparambil A Ajith
Hypoxia-inducible factors (HIFs) are transcription factors that are expressed in the hypoxic tumor microenvironment. They are involved in the cellular adaptations by improving the metabolism of glucose and enhance the expression of vascular endothelial growth factor, platelet-derived growth factor and angiopoietin, thereby they play a pivotal role in the angiogenesis. Hypoxia can increase the expression of nuclear factor-kappa B which promotes the pro-inflammatory status. Abnormally high angiogenesis, inflammation, antiapoptosis and anaerobic glycolysis can augment the progression and metastasis of tumor...
September 27, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30205645/proline-supplementation-mitigates-the-early-stage-of-liver-injury-in-bile-duct-ligated-rats
#8
Reza Heidari, Hamidreza Mohammadi, Vahid Ghanbarinejad, Asrin Ahmadi, Mohammad Mehdi Ommati, Hossein Niknahad, Akram Jamshidzadeh, Negar Azarpira, Narges Abdoli
No abstract text is available yet for this article.
September 6, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30179850/hepatoprotective-activity-of-tamarindus-indica-linn-stem-bark-ethanolic-extract-against-hepatic-damage-induced-by-co-administration-of-antitubercular-drugs-isoniazid-and-rifampicin-in-sprague-dawley-rats
#9
Shaikh Zohra Meena, Md Azizur Rahman, Paramdeep Bagga, Md Mujahid
No abstract text is available yet for this article.
September 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30179849/primary-concept-of-nickel-toxicity-an-overview
#10
REVIEW
Kusal K Das, R Chandramouli Reddy, Ishwar B Bagoji, Swastika Das, Shrilaxmi Bagali, Lata Mullur, Jyoti P Khodnapur, M S Biradar
No abstract text is available yet for this article.
September 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30173204/drug-induced-optic-neuropathy-in-a-case-of-extensively-drug-resistant-pulmonary-tuberculosis
#11
Proteesh Rana, Vandana Roy, Jamshed Ahmad
No abstract text is available yet for this article.
September 3, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30157032/alleviation-of-carbon-tetrachloride-induced-hepatocellular-damage-and-oxidative-stress-with-a-leaf-extract-of-glyphae-brevis-tiliaceae
#12
Lucky Legbosi Nwidu, Yibala I Oboma, Ekramy Elmorsy, Wayne Grant Carter
No abstract text is available yet for this article.
August 29, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30133418/attenuation-of-oxidative-stress-and-hepatic-damage-by-white-butterfly-clerodendrum-volubile-leaves-in-streptozotocin-induced-diabetes-in-rats
#13
Olorunfemi R Molehin, Omotade I Oloyede
No abstract text is available yet for this article.
August 22, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30120910/re-establishing-normal-diet-following-high-fat-diet-induced-obesity-reverses-the-altered-salivary-composition-in-wistar-rats
#14
Taye Jemilat Lasisi, Shehu-Tijani Toyin Shittu, Akinola Rasak Alada
No abstract text is available yet for this article.
August 18, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30110251/zataria-multiflora-extract-and-carvacrol-affect-cardiotoxicity-induced-by-adriamycin-in-rat
#15
Abolfazl Khajavi Rad, Reza Mohebbati
No abstract text is available yet for this article.
August 15, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30099411/effect-of-caffeine-on-alcohol-consumption-and-alcohol-induced-conditioned-place-preference-in-rodents
#16
Agbonlahor Okhuarobo, Ighodaro Igbe, Abdulmajid Yahaya, Zakariya Sule
Background The aim of the study was to determine the effect of caffeine on alcohol consumption with or without deprivation and alcohol-induced conditioned place preference. Methods In the present study, we examined the effects of caffeine (2.5, 5 and 10 mg/kg) on alcohol consumption in Wistar rats with or without periods of deprivation in an unlimited-access, two-bottle, free choice drinking procedure after a stable baseline alcohol consumption was established. Conditioned place preference (CPP) was established by intraperitoneal injections of alcohol (2 g/kg) in a 12-day conditioning schedule in mice...
August 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30099410/local-inhibition-of-carbonic-anhydrase-does-not-decrease-sweat-rate
#17
Jeff Moore, Sarah Northway, Nicole Wells, Emily Woolf, Michael J Buono
BACKGROUND: The purpose of this study was to measure sweat rate during exercise in the heat after directly inhibiting carbonic anhydrase (CA) in eccrine sweat glands via transdermal iontophoresis of acetazolamide. It was hypothesized that if CA was important for sweat production, local administration of acetazolamide, without the confounding systemic effects of dehydration typically associated with past studies, would have a significant effect on sweat rate during exercise. METHODS: Ten healthy subjects volunteered to exercise in the heat following acetazolamide or distilled water iontophoresis on the forearm...
August 13, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30091949/screening-of-the-immunomodulatory-and-antibacterial-activity-of-termitomyces-letestui-pat-heim-lyophyllaceae-an-edible-mushroom-from-cameroon
#18
Oumar Mahamat, Tume Christopher, Njouonkou Andre-Ledoux, Amadoh Jude, Nfor Ndiane, Kamanyi Albert
Background Globally, Termitomyces letestui is used by different communities to treat various illnesses, including bacterial infection, although with limited scientific evidence. The current study aims to assess the immunomodulatory and antibacterial properties of the water extract of a wild mushroom, T. letestui in mice model. Methods The base study was completed following the standard methods and procedures using white mice Mus musculus. The immunomodulatory was investigated for humoral and cell-mediated response in both the normal and dexamethasone-immunosuppressed mice...
August 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30089097/pharmacotherapy-of-ulcerative-colitis-current-status-and-emerging-trends
#19
REVIEW
Hilal Ahmad, Vijay L Kumar
Ulcerative colitis (UC) is a chronic mucosal inflammation of the large intestine restricted to the rectum and colon. Its clinical course follows an intermittent pattern with episodes of relapse, followed by remission and eventually resulting in mucosal damage. Although there is no permanent cure for UC, the currently available pharmacotherapy aims to induce and maintain clinical remission, promote the healing of colonic mucosa and avert any surgical intervention. The conventional drug therapy comprising of 5-aminosalicylates, thiopurines and corticosteroids has advanced recently in terms of formulations and dosing schedule, resulting in improved efficacy, safety and compliance...
August 8, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/30085930/in-vivo-analgesic-effect-of-different-extracts-of-hopea-odorata-leaves-in-mice-and-in-silico-molecular-docking-and-adme-t-property-analysis-of-some-isolated-compounds-from-this-plant
#20
Md Sajjad Ul Hoque, Mohammed Sohel Chowdhury, Arkajyoti Paul, Jackie Barua, Syeda Sakiatuz Zannat, Md Mehedi Hasan, Shaibal Das Gupta, Sagar Barua, Sabbir Ahmed, Mohammad Shah Hafez Kabir
Background The current study evaluates the analgesic effect of different extracts of Hopea odorata leaves in mice followed by molecular docking and absorption, distribution, metabolism, excretion, and toxicity (ADME/T) analysis of isolated compounds derived from the plant with the COX-1 enzyme. Methods In the present study, the dried leaves of H. odorata were subjected to extraction using methanol, ethanol, and water. In vivo analgesic activity was evaluated by using the acetic acid-induced writhing test and formalin-induced paw licking test, and in silico molecular docking and ADME/T study were performed using Schrödinger Maestro (version 11...
August 7, 2018: Journal of Basic and Clinical Physiology and Pharmacology
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