Siyi Li, Yinmu Zheng, Yurong Kang, Xiaofen He, Yu Zheng, Minjian Jiang, Xinnan Xu, Liqian Ma, Xiaoxiang Wang, Kunlong Zhang, Xiaomei Shao, Jianqiao Fang, Yongliang Jiang
Diabetic neuropathic pain (DNP) is a frequent complication of diabetes. Calcium/calmodulin-dependent protein kinase II α (CaMKIIα), a multi-functional serine/threonine kinase subunit, is mainly located in the surface layer of the spinal cord dorsal horn (SCDH) and the primary sensory neurons in dorsal root ganglion (DRG). Numerous studies have indicated electroacupuncture (EA) takes effect in various kinds of pain. In this research, we explored whether CaMKIIα on rats' SCDH and DRG participated in DNP and further explored the mechanisms underlying the analgesic effects of EA...
March 6, 2024: Neuroreport