Read by QxMD icon Read


Jianjun Yang, Yongtao Lyu, Yue Ma, Yan Chen
Cerebral microbleeds (CMBs) have been identified as an important manifestation and diagnostic marker of cerebrovascular disease, but there are also some controversies about the impact of CMBs on cognition. The current cross-sectional study aimed to clarify the relationship between CMBs and cognitive impairment in patients with ischemic cerebrovascular disease. One hundred and fifty patients with lacunar infarction or transient ischemic attack were screened, and all of them were scanned by brain MRI. In the end, 125 patients who were divided into a CMBs group and a non-CMBs group were selected and completed the cognitive tests...
July 12, 2018: Neuroreport
Shenglong Guo, Ruili Chen, Xiaoli Chen, Zhen Xie, Fangfang Huo, Zhongliang Wu
Accumulating evidence suggests that Che-1 is a strong antiapoptotic protein and can protect cells against various insults. However, whether Che-1 is involved in the protection of neurons against cerebral ischemia/reperfusion injury remains unclear. In this study, we aimed to investigate the potential role of Che-1 in regulating cerebral ischemia/reperfusion injury-induced neuronal injury using the oxygen-glucose deprivation and reoxygenation (OGD/R) model in vitro. We found that Che-1 expression was induced in neurons following OGD/R treatment...
July 11, 2018: Neuroreport
Qun Yang, Peng Huang, Chen Li, Peng Fang, Ningxia Zhao, Jie Nan, Bingzhao Wang, Wei Gao, Long-Biao Cui
This study aimed to identify the neuroanatomical substrates and white matter connectivity in children with autism spectrum disorder (ASD) and the association between gray matter and structural connectivity. A total of 36 children including patients with ASD and healthy controls between 6 and 15 years of age were enrolled in this study. High-resolution structural MRI and functional MRI were performed and analyzed using voxel-based morphometry and tract-based spatial statistics. The relationship between gray matter volume and structural connectivity was generated using Pearson correlation analysis...
July 11, 2018: Neuroreport
Adriano E Machado, Guilherme de Sousa, Gianni Mancini, Moacir S Faria, Andreza F de Bem, Eduardo L G Moreira
The present study evaluated the effects of hypercholesterolemia in response to conditioned aversive stimuli in mice. Specifically, (a) young (3 months old) and aged (24 months old) female C57Bl/6 mice were fed daily for 4 weeks with a standard rodent diet or an enriched cholesterol diet (ECD) and then subjected to the contextual fear conditioning test. In another experimental set, 3-month-old C576Bl/6 female mice, fed daily during the 4 weeks with the standard rodent diet or ECD, were subjected to the contextual fear conditioning test and received vehicle or scopolamine (0...
July 9, 2018: Neuroreport
Teng Wang, Ying Liu, Xi Liu, Xin Wei, Xueying Ding, Lijuan Mo, Hui Wang, Wen Zhou, Tao Xu, Fen Deng, Lifen Chen
Golgi-specific DHHC type zinc finger protein (GODZ) is a member of the DHHC protein family, and its enzymatic activity is regulated by fibroblast growth factor or Src kinase-mediated tyrosine phosphorylation. In cultured neurons, GODZ affects the numbers of calcium ions channels, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors, N-methy-D-aspartate receptors, and γ-aminobutyric acid A receptors on postsynaptic membrane by palmitoylation, thus modulating synaptic plasticity. As the change in synaptic plasticity plays a role in epilepsy, GODZ may play roles in epilepsy...
July 9, 2018: Neuroreport
Xiuhua Dong, Huixian Li, Jiakai Lu, Yanwei Yang, He Jing, Yi Cheng, Mu Jin, Weiping Cheng
Microglial activation plays a critical role in spinal cord ischemic reperfusion injury. Spinal cord stimulation preconditioning and postconditioning has shown spinal cord protection in ischemic reperfusion injury in animal studies. However, whether spinal cord stimulation could reduce microglial activation is still unclear. In this study, rabbits experienced 28-min infrarenal aorta occlusion and reperfusion for 8 h, 1, 3, and 7 days correspondingly. Immediately after reperfusion, rabbits received spinal cord stimulation of 2 or 50 Hz for 30 min and daily for a week...
July 9, 2018: Neuroreport
Qian Zhang, Zhao Na, Yanna Cheng, Fengshan Wang
The neurotoxicity of aggregated amyloid β (Aβ) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease. In a previous work, we have shown that low-molecular-weight chondroitin sulfate (LMWCS), a derivative of chondroitin sulfate, protected the SH-SY5Y neuroblastoma cells from Aβ25-35-induced neurotoxicity, decreased intracellular reactive oxygen species level and inhibited the cell apoptosis. However, the underlying mechanism of the antioxidative effect of LMWCS in the SH-SY5Y cells has not been well explored...
July 6, 2018: Neuroreport
Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Pei-Hao Zhang, Yi-Da Xu, Zhi-Lan Zhou, Zhou-Heng Xu, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin Shen
Aucubin (AUC) is a major bioactive ingredient in Eucommia ulmoides, Plantain asiatica, and Aucuba japonica, and has been shown to exert anti-inflammatory, antioxidative, and neuroprotective effects. We explore the neuroprotective effects of AUC in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian mice. Mice were administered MPTP (30 mg/kg) daily for 5 days, followed by treatment with AUC for 7 days. Measurement of dopamine levels was performed by high-performance liquid chromatography and tyrosine hydroxylase expression was assessed by western blot...
July 5, 2018: Neuroreport
ZhenYu Wang, LinQuan Zhou, XiaoTing Zheng, WenGe Liu
Previous studies have indicated that spinal cord injury can induce autophagy. To a certain extent, increased autophagy has a protective effect on neurons. Early hormone therapy is well recognized as a treatment for spinal cord injury. However, whether the protective effect of autophagy is important in recovery from spinal cord injury remains unclear. In this study, we established an in-vitro model of spinal cord injury to study the effects of dexamethasone on mechanical injury, autophagy, and apoptosis in spinal cord neurons...
July 5, 2018: Neuroreport
Huanyin Li, Lan Zheng, Aihua Jiang, Yankqing Mo, Qi Gong
BC200 is a long noncoding RNA expressed at high levels in the Alzheimer's disease (AD), and blocking of BC200 by siRNA is assumed to be an effective method for various disease therapy. We have established an AD cell model overexpressing amyloid β-peptide (Aβ)1-42 to observe the effects of BC200 on the cell viability and apoptosis, and to investigate the associated underlying mechanisms. Efficient knockdown and overexpression of BC200 were established using BC200 siRNA and BC200 mimics, respectively. Cell viability following BC200 knockdown and overexpression was assessed by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyltetrazolium bromide assay, and cell apoptosis was monitored by flow cytometry...
July 3, 2018: Neuroreport
Yunling Wang, Yihai Lin
This work aimed to investigate the inter-regulatory functions of hsa-mir-127 and replication initiator 1 (REPIN1) on the proliferation and metastasis of glioma cells. The in-silico data on the implication of hsa-mir-127 and REPIN1 in glioma were retrieved from The Cancer Genome Atlas (TCGA). The expression levels of hsa-mir-127 and REPIN1 mRNA were determined by qRT-PCR, whereas Western blot was used to detect REPIN1 protein expression in glioma cell lines. The proliferation of glioma cells was determined by means of the MTT assay, whereas the transwell assay was employed for assessing the extent of cell migration and invasion...
July 3, 2018: Neuroreport
Qiu-Gen Li, Fu-Qing Zhou, Xin Huang, Xiong Zhou, Chao Liu, Ting Zhang, Huan-Yu Li, Xiao-Rong Wu, Jun Wang
Several previous studies have reported that asthma patients have abnormal brain activities, whereas alterations in the resting-state network still remain unknown. The aim of this study was to investigate the changes in functional network centrality in asthma patients using voxel-wise degree centrality (DC) method. Asthma patients and healthy controls (HCs) were matched closely in age, sex, and education of participants. The DC method was used to evaluate the functional network centrality. The receiver operating characteristic curve was used to distinguish the asthma group from the HCs group...
July 2, 2018: Neuroreport
Chenchang Bao, Yanan Yang, Huiyang Huang, Haihui Ye
Voltage-dependent calcium channels (VDCCs) play a critical role in stimulus-secretion coupling in neurosecretory cells (NSCs). The crustacean cerebral ganglion plays a crucial role in neuromodulation and controls neuropeptide release. The present study used patch-clamp and Illumina sequencing techniques to investigate the potential features of VDCC in the cerebral ganglia of the mud crab (Scylla paramamosain). The electrophysiological characteristics of VDCC were analyzed in three types of NSCs with a patch clamp...
June 30, 2018: Neuroreport
Yalei Li, Baosen Guo, Rong Yang, Zengrong Xiao, Xuehu Gao, Jinjun Yu, Siguang Li, Yuping Luo
Long noncoding RNAs have been implicated in oligodendrocyte myelination and oligodendrocyte maturation, but their roles in normal oligodendrocyte differentiation are not fully defined. Here, we report a novel nonprotein-coding RNA, named lnc158, discovered in mouse oligodendrocytes identified in subependymal ventricular zone tissue by single-cell RNA sequencing. Lnc158 is an endogenous antisense transcript of nuclear factor-IB (NFIB) and complementary to 3' untranslated region of NFIB mRNA. NFIB is a member of the nuclear factor-I family and is essential in the development of many organs such as brains and lungs...
June 30, 2018: Neuroreport
Yohei Okada, Tomoyuki Shiozaki, Junji Nakamura, Yuji Azumi, Miyo Inazato, Moe Ono, Honoka Kondo, Miyuki Sugitani, Akiyoshi Matsugi
Modulation of the soleus H-reflex following galvanic vestibular stimulation (GVS) has been used to evaluate vestibulospinal tract function. It is not known whether this modulation is because of vestibular stimulation and/or cutaneous stimulation, and the suitable stimulating intensity of GVS for the modulation is not established. We investigated the influence of GVS intensity and cutaneous stimulation on the soleus H-reflex in healthy adults. We applied cathodal GVS (at 1, 2, and 3 mA) or 3-mA cutaneous stimulation as a conditioning stimulation in a random order to 17 individuals in the prone position with the head facing forward, and we examined the changes in the right soleus H-reflex amplitude...
June 30, 2018: Neuroreport
Jaclyn H Ford, Elizabeth A Kensinger
Previous research has revealed an age-related shift in how individuals recall events from their personal past, with older adults reporting events that are more positive than young adults. We recently showed that age-by-valence interactions may be partially driven by a prefrontally mediated control mechanism recruited by older adults during retrieval of negative laboratory events to reduce phenomenological richness. Specifically, age was associated with greater increases in prefrontal recruitment during retrieval of negative relative to positive events, with this recruitment linked to decreases in hippocampal activity and subjective vividness ratings...
June 30, 2018: Neuroreport
Yong Wang, Xingqiang Lai, Lihua Huang, Guangjian Liu, Zhicheng Zai, Deli Zhu, Yan Zhang, Zijian Liang, Zhiguang Yao, Yunpei Chen, Zhe Wen, Huimin Xia
Hirschsprung disease (HSCR) is a complex genetic disorder of the enteric nervous system that is characterized by a complete loss of the neuronal ganglion cells in the intestinal tract. It is one of the most frequent causes of congenital intestinal obstruction and more than 80% of the causative mutations are in RET. Here, we identified a new RET mutation in a patient and established a cell model that can be used to elucidate the pathogenesis of HSCR. Peripheral blood was collected from a patient who was clinically and pathologically diagnosed with HSCR with a heterozygous deletion mutation (c...
June 29, 2018: Neuroreport
Lin-Hui Ni, Shu-Xia Cao, Hong Lian, Xing-Yue Hu
The central cholinergic nervous system plays an important role in cognition, with acetylcholine hypofunction considered to be a major factor of dementia. Botulinum toxin type A (BoNT/A), a potent poison secreted by Clostridium botulinum, is used widely for dystonia treatment and facial cosmesis. BoNT/A injection inhibits acetylcholine release in the neuromuscular junction through cleavage of synaptosomal-associated protein of 25 kDa in cholinergic terminals. Furthermore, beyond the injection site, BoNT/A undergoes retrograde transport and transcytosis to the central nervous system from peripheral cholinergic terminals...
June 29, 2018: Neuroreport
Samantha L Hodges, Conner D Reynolds, Gregory D Smith, Taylor S Jefferson, Suzanne O Nolan, Joaquin N Lugo
Dysregulation of the PI3K/Akt/mTOR signaling cascade has been associated with the pathology of neurodegenerative disorders, specifically Alzheimer's disease (AD). Both in-vivo models and post-mortem brain samples of individuals with AD have commonly shown hyperactivation of the pathway. In the present study, we examine how neuron subset-specific deletion of Pten (NS-Pten) in mice, which presents with hyperactive mammalian target of rapamycin (mTOR) activity, affects the hippocampal protein levels of key neuropathological hallmarks of AD...
June 29, 2018: Neuroreport
Ya-Ting Deng, Xin-Shang Wang, Ming-Gao Zhao, Xuan-Xuan Huang, Xiao-Li Xu
The effects of gentiopicroside (Gent), an active component derived from the traditional Chinese medicine Gentiana macrophylla, on lipopolysaccharide-induced astrocyte activation and subsequent neuronal damage were investigated. Gent significantly inhibited the release of tumor necrosis factor-α, interleukin-1β, nitric oxide, and prostaglandin E, as well as expressions of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-induced primary astrocytes. Furthermore, Gent relieved neurotoxicity from astrocyte-mediated inflammatory injury...
June 28, 2018: Neuroreport
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"