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Mammalian Genome: Official Journal of the International Mammalian Genome Society

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https://www.readbyqxmd.com/read/30390107/introduction-to-mammalian-genome-special-issue-inflammation-and-immunity-in-cancer
#1
EDITORIAL
Andreas Behren, Daniel Speidel, George Kollias, Viive M Howell
No abstract text is available yet for this article.
November 2, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30370456/correction-to-the-role-of-proteomics-in-the-age-of-immunotherapies
#2
Sarah A Hayes, Stephen Clarke, Nick Pavlakis, Viive M Howell
Some parts of the Abstract, Introduction and Discussion included uncited text from the following previously published chapter.
October 29, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30225648/lessons-learnt-from-the-tasmanian-devil-facial-tumour-regarding-immune-function-in-cancer
#3
REVIEW
Emma Peel, Katherine Belov
Genetic and genomic technologies have facilitated a greater understanding of the Tasmanian devil immune system and the origins, evolution and spread of devil facial tumour disease (DFTD). DFTD is a contagious cancer that has caused significant declines in devil populations across Tasmania. Immune responses to DFTD are rarely detected, allowing the cancer to pass between individuals and proliferate unimpeded. Early immunosenscence in devils appears to decrease anti-tumour immunity in older animals compared to younger animals, which may increase susceptibility to DFTD and explain high DFTD prevalence in this age group...
September 17, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30206651/nlrp3-inflammasome-in-colitis-and-colitis-associated-colorectal-cancer
#4
REVIEW
Agampodi Promoda Perera, Karishma Sajnani, Joanne Dickinson, Rajaraman Eri, Heinrich Körner
A low level of inflammation is an integral part of the balance between the immune system and the microbiota in the high antigen environment of the gastrointestinal tract and maintains homeostasis. A failure of this balance can lead to chronic intestinal inflammation and increase the chances to develop colorectal cancer significantly. The underlying mechanisms that link inflammation and carcinogenesis are not clear but the molecular platforms of the inflammasomes have been implicated. Inflammasomes are molecule complexes that are assembled in response to microbial components or cellular danger signals and facilitate the production of bioactive pro-inflammatory cytokines...
September 11, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30182300/thymocyte-self-renewal-and-oncogenic-risk-in-immunodeficient-mouse-models-relevance-for-human-gene-therapy-clinical-trials-targeting-haematopoietic-stem-cell-populations
#5
REVIEW
Samantha L Ginn, Matthew P McCormack, Ian E Alexander
Emerging evidence indicates that thymocyte self-renewal induced by progenitor deprivation carries an oncogenic risk that is modulated by intra-thymic competition from differentiation-committed cells. Here we discuss formative studies demonstrating that, in mice, early thymocytes acquire self-renewing potential when thymic progenitor supply is sub-physiological and the importance of cellular competition with this at-risk cell population to prevent lymphoid malignancy. We also consider the possibility that increased thymic residency time, established under conditions of limited cellular competition, may have contributed to oncogenesis observed in early SCID-X1 trials when combined with insertional activation of proto-oncogenes such as LMO2...
September 4, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178306/roles-of-cytotoxic-and-helper-innate-lymphoid-cells-in-cancer
#6
REVIEW
Camille Guillerey
Natural killer (NK) cells have long been recognized for their anti-cancer activity and are now included in the large family of innate lymphoid cells (ILCs). The discovery of new ILC subsets that, similarly to NK cells, are able to kill tumor cells encourages us to redefine NK cell role in anti-tumor immunity. Conventional NK cells circulate through the blood and screen the body for "stressed" cells. Therefore, NK cells are believed to play a key role in cancer immunosurveillance by the early elimination of cells undergoing malignant transformation...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178305/radiation-inflammation-and-the-immune-response-in-cancer
#7
REVIEW
Kelly J McKelvey, Amanda L Hudson, Michael Back, Tom Eade, Connie I Diakos
Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour microenvironment and more specifically the inflammatory/immune response is less well characterised. Inflammation is a key contributor to short- and long-term cancer eradication, with significant tumour and normal tissue consequences...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178304/b-cells-and-antibody-production-in-melanoma
#8
REVIEW
Jessica Da Gama Duarte, Janique M Peyper, Jonathan M Blackburn
Recent developments in the immuno-oncology field strongly support a role for the immune system in both the prevention and progression of melanoma. Melanoma is a highly immunogenic cancer, including its ability to induce tumour antigen-specific B cell and antibody responses through largely unknown mechanisms. This review considers likely hypothetical mechanisms by which anti-tumour surveillance detects pre-cancerous cells and by which immune (including B cell and antibody) responses may be elicited during malignancy...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30167844/identifying-neoantigens-for-use-in-immunotherapy
#9
REVIEW
Sharon Hutchison, Antonia L Pritchard
This review focuses on the types of cancer antigens that can be recognised by the immune system and form due to alterations in the cancer genome, including cancer testis, overexpressed and neoantigens. Specifically, neoantigens can form when cancer cell-specific mutations occur that result in alterations of the protein from 'self'. This type of antigen can result in an immune response sufficient to clear tumour cells when activated. Furthermore, studies have reported that the likelihood of successful immunotherapeutic targeting of cancer by many different methods was reliant on immune response to neoantigens...
August 24, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30132062/interaction-of-pvr-pvrl2-with-tigit-dnam-1-as-a-novel-immune-checkpoint-axis-and-therapeutic-target-in-cancer
#10
REVIEW
Hauke Stamm, Jasmin Wellbrock, Walter Fiedler
Avoiding immune surveillance and inducing a tumor-promoting inflammatory milieu found entry into the new generation of the hallmarks of cancer. Cancer cells hijack immune mechanisms which physiologically protect the body from the development of autoimmune diseases and excessive tissue damage during inflammation by downregulating immune responses. This is frequently achieved by upregulation of immune checkpoints. Therefore, the blocking of immune checkpoint ligand-receptor interactions can reinstall the immune systems capability to fight cancer cells as shown for CTLA4 and PD-1 inhibitors in a clinical setting...
August 21, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30225647/transgenic-mice-with-a-tandem-duplication-of-the-necdin-gene-overexpress-necdin
#11
Ayumi Nakagaki, Shiori Hirano, Asuka Urakawa, Maiko Mitake, Tatsuya Kishino
Necdin (Ndn) transgenic (Tg) mice were generated with a bacterial artificial chromosome (BAC) clone. Droplet digital PCR (ddPCR) and inverse PCR methods revealed that the transgene consisted of four fragments with a total length of 171 kb. Two of these fragments were tandem tail-to-tail duplicates of 77 kb and 37 kb that both contained a Ndn gene. The transgene was inserted in chromosome 15qD1. Ndn is a paternally expressed imprinted gene; however, the total expression level of Ndn in hemizygous Tg mice was approximately twofold higher than that in wild-type mice...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30173367/fine-mapping-of-the-major-bleomycin-induced-pulmonary-fibrosis-susceptibility-locus-in-mice
#12
Marie-Eve Bergeron, Anguel Stefanov, Christina K Haston
Susceptibility to fibrotic lung disease differs among people and among inbred strains of mice exposed to bleomycin where C57BL/6J mice are susceptible and C3H/HeJ mice are spared fibrotic disease. Genetic mapping studies completed in offspring derived from these inbred strains revealed the inheritance of C57BL/6J alleles at loci, including the major locus on chromosome 17, called Blmpf1 bleomycin-induced pulmonary fibrosis 1, to be linked to pulmonary fibrosis in treated mice. In the present study, to reduce the interval of Blmpf1, we bred and phenotyped a panel of subcongenic mice with C3H/HeJ alleles in a C57BL/6J background...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30171338/genetic-mapping-of-a-male-factor-subfertility-locus-on-mouse-chromosome-4
#13
Hideo Gotoh, Ikuo Miura, Shigeharu Wakana
Male reproductive anomalies are widely distributed among mammals, and male factors are estimated to contribute to approximately 50% of cases of human infertility. The B10.M/Sgn (B10.M) mouse strain exhibits two adverse reproductive phenotypes: severe teratospermia and male subfertility. Although teratospermia is known to be heritable, the relationship between teratospermia and male subfertility has not been well characterized. The fertility of B10.M male mice is considerably lower (~ 30%) than that of standard laboratory mouse strains (~ 70%)...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30094508/identification-of-reference-genes-suitable-for-rt-qpcr-studies-of-murine-gastrulation-and-patterning
#14
Kristen S Barratt, Koula E M Diamand, Ruth M Arkell
Quantitative reverse transcriptase PCR (RT-qPCR), a powerful and efficient means of rapidly comparing gene expression between experimental conditions, is routinely used as a phenotyping tool in developmental biology. The accurate comparison of gene expression across multiple embryonic stages requires normalisation to reference genes that have stable expression across the time points to be examined. As the embryo and its constituent tissues undergo rapid growth and differentiation during development, reference genes known to be stable across some time points cannot be assumed to be stable across all developmental stages...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30073618/in-silico-mapping-of-quantitative-trait-loci-qtl-regulating-the-milk-ionome-in-mice-identifies-a-milk-iron-locus-on-chromosome-1
#15
Darryl L Hadsell, Louise A Hadsell, Monique Rijnkels, Yareli Carcamo-Bahena, Jerry Wei, Peter Williamson, Michael A Grusak
The breast-feeding neonate depends on mother's milk for both macronutrients and micronutrients including minerals. The goals of the present study were to document the effects of genetic background in mice on milk concentrations of select minerals and to use genome-wide association study (GWAS) to identify quantitative trait loci (QTL) regulating milk mineral concentrations. Milk samples from lactating mice in each of 31 different inbred strains of the mouse diversity panel (MDP) were analyzed by inductively coupled plasma-optical emission spectroscopy to determine the concentrations of calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), sulfur (S), and zinc (Zn)...
October 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30171339/host-genetic-regulation-of-immune-based-and-infectious-diseases-introduction-to-mammalian-genome-special-issue-genetics-of-infectious-disease
#16
EDITORIAL
Martin T Ferris, Derek W Hood
No abstract text is available yet for this article.
August 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30167845/insights-into-the-pathogenesis-of-herpes-simplex-encephalitis-from-mouse-models
#17
REVIEW
Mathieu Mancini, Silvia M Vidal
A majority of the world population is infected with herpes simplex viruses (HSV; human herpesvirus types 1 and 2). These viruses, perhaps best known for their manifestation in the genital or oral mucosa, can also cause herpes simplex encephalitis, a severe and often fatal disease of the central nervous system. Antiviral therapies for HSV are only partially effective since the virus can establish latent infections in neurons, and severe pathological sequelae in the brain are common. A better understanding of disease pathogenesis is required to develop new strategies against herpes simplex encephalitis, including the precise viral and host genetic determinants that promote virus invasion into the central nervous system and its associated immunopathology...
August 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30167843/host-genetic-control-of-mosquito-borne-flavivirus-infections
#18
REVIEW
Caroline Manet, Claude Roth, Ahmed Tawfik, Tineke Cantaert, Anavaj Sakuntabhai, Xavier Montagutelli
Flaviviruses are arthropod-borne viruses, several of which represent emerging or re-emerging pathogens responsible for widespread infections with consequences ranging from asymptomatic seroconversion to severe clinical diseases and congenital developmental deficits. This variability is due to multiple factors including host genetic determinants, the role of which has been investigated in mouse models and human genetic studies. In this review, we provide an overview of the host genes and variants which modify susceptibility or resistance to major mosquito-borne flaviviruses infections in mice and humans...
August 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30151711/genetic-control-of-alphavirus-pathogenesis
#19
REVIEW
Victoria K Baxter, Mark T Heise
Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus), though some patients who recover from the initial acute illness may develop long-term sequelae, regardless of the specific infecting virus...
August 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30143822/the-collaborative-cross-mouse-model-for-dissecting-genetic-susceptibility-to-infectious-diseases
#20
REVIEW
Hanifa Abu Toamih Atamni, Aysar Nashef, Fuad A Iraqi
Infectious diseases, also known as communicable diseases, refer to a full range of maladies caused by pathogen invasion to the host body. Host response towards an infectious pathogen varies between individuals, and can be defined by responses from asymptomatic to lethal. Host response to infectious pathogens is considered as a complex trait controlled by gene-gene (host-pathogen) and gene-environment interactions, leading to the extensive phenotypic variations between individuals. With the advancement of the human genome mapping approaches and tools, various genome-wide association studies (GWAS) were performed, aimed at mapping the genetic basis underlying host susceptibility towards infectious pathogens...
August 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
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