journal
MENU ▼
Read by QxMD icon Read
search

Mammalian Genome: Official Journal of the International Mammalian Genome Society

journal
https://www.readbyqxmd.com/read/30225648/lessons-learnt-from-the-tasmanian-devil-facial-tumour-regarding-immune-function-in-cancer
#1
REVIEW
Emma Peel, Katherine Belov
Genetic and genomic technologies have facilitated a greater understanding of the Tasmanian devil immune system and the origins, evolution and spread of devil facial tumour disease (DFTD). DFTD is a contagious cancer that has caused significant declines in devil populations across Tasmania. Immune responses to DFTD are rarely detected, allowing the cancer to pass between individuals and proliferate unimpeded. Early immunosenscence in devils appears to decrease anti-tumour immunity in older animals compared to younger animals, which may increase susceptibility to DFTD and explain high DFTD prevalence in this age group...
September 17, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30225647/transgenic-mice-with-a-tandem-duplication-of-the-necdin-gene-overexpress-necdin
#2
Ayumi Nakagaki, Shiori Hirano, Asuka Urakawa, Maiko Mitake, Tatsuya Kishino
Necdin (Ndn) transgenic (Tg) mice were generated with a bacterial artificial chromosome (BAC) clone. Droplet digital PCR (ddPCR) and inverse PCR methods revealed that the transgene consisted of four fragments with a total length of 171 kb. Two of these fragments were tandem tail-to-tail duplicates of 77 kb and 37 kb that both contained a Ndn gene. The transgene was inserted in chromosome 15qD1. Ndn is a paternally expressed imprinted gene; however, the total expression level of Ndn in hemizygous Tg mice was approximately twofold higher than that in wild-type mice...
September 17, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30206651/nlrp3-inflammasome-in-colitis-and-colitis-associated-colorectal-cancer
#3
REVIEW
Agampodi Promoda Perera, Karishma Sajnani, Joanne Dickinson, Rajaraman Eri, Heinrich Körner
A low level of inflammation is an integral part of the balance between the immune system and the microbiota in the high antigen environment of the gastrointestinal tract and maintains homeostasis. A failure of this balance can lead to chronic intestinal inflammation and increase the chances to develop colorectal cancer significantly. The underlying mechanisms that link inflammation and carcinogenesis are not clear but the molecular platforms of the inflammasomes have been implicated. Inflammasomes are molecule complexes that are assembled in response to microbial components or cellular danger signals and facilitate the production of bioactive pro-inflammatory cytokines...
September 11, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30182300/thymocyte-self-renewal-and-oncogenic-risk-in-immunodeficient-mouse-models-relevance-for-human-gene-therapy-clinical-trials-targeting-haematopoietic-stem-cell-populations
#4
REVIEW
Samantha L Ginn, Matthew P McCormack, Ian E Alexander
Emerging evidence indicates that thymocyte self-renewal induced by progenitor deprivation carries an oncogenic risk that is modulated by intra-thymic competition from differentiation-committed cells. Here we discuss formative studies demonstrating that, in mice, early thymocytes acquire self-renewing potential when thymic progenitor supply is sub-physiological and the importance of cellular competition with this at-risk cell population to prevent lymphoid malignancy. We also consider the possibility that increased thymic residency time, established under conditions of limited cellular competition, may have contributed to oncogenesis observed in early SCID-X1 trials when combined with insertional activation of proto-oncogenes such as LMO2...
September 4, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178306/roles-of-cytotoxic-and-helper-innate-lymphoid-cells-in-cancer
#5
REVIEW
Camille Guillerey
Natural killer (NK) cells have long been recognized for their anti-cancer activity and are now included in the large family of innate lymphoid cells (ILCs). The discovery of new ILC subsets that, similarly to NK cells, are able to kill tumor cells encourages us to redefine NK cell role in anti-tumor immunity. Conventional NK cells circulate through the blood and screen the body for "stressed" cells. Therefore, NK cells are believed to play a key role in cancer immunosurveillance by the early elimination of cells undergoing malignant transformation...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178305/radiation-inflammation-and-the-immune-response-in-cancer
#6
REVIEW
Kelly J McKelvey, Amanda L Hudson, Michael Back, Tom Eade, Connie I Diakos
Radiation is an important component of cancer treatment with more than half of all patients receive radiotherapy during their cancer experience. While the impact of radiation on tumour morphology is routinely examined in the pre-clinical and clinical setting, the impact of radiation on the tumour microenvironment and more specifically the inflammatory/immune response is less well characterised. Inflammation is a key contributor to short- and long-term cancer eradication, with significant tumour and normal tissue consequences...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30178304/b-cells-and-antibody-production-in-melanoma
#7
REVIEW
Jessica Da Gama Duarte, Janique M Peyper, Jonathan M Blackburn
Recent developments in the immuno-oncology field strongly support a role for the immune system in both the prevention and progression of melanoma. Melanoma is a highly immunogenic cancer, including its ability to induce tumour antigen-specific B cell and antibody responses through largely unknown mechanisms. This review considers likely hypothetical mechanisms by which anti-tumour surveillance detects pre-cancerous cells and by which immune (including B cell and antibody) responses may be elicited during malignancy...
September 3, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30173367/fine-mapping-of-the-major-bleomycin-induced-pulmonary-fibrosis-susceptibility-locus-in-mice
#8
Marie-Eve Bergeron, Anguel Stefanov, Christina K Haston
Susceptibility to fibrotic lung disease differs among people and among inbred strains of mice exposed to bleomycin where C57BL/6J mice are susceptible and C3H/HeJ mice are spared fibrotic disease. Genetic mapping studies completed in offspring derived from these inbred strains revealed the inheritance of C57BL/6J alleles at loci, including the major locus on chromosome 17, called Blmpf1 bleomycin-induced pulmonary fibrosis 1, to be linked to pulmonary fibrosis in treated mice. In the present study, to reduce the interval of Blmpf1, we bred and phenotyped a panel of subcongenic mice with C3H/HeJ alleles in a C57BL/6J background...
September 1, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30171339/host-genetic-regulation-of-immune-based-and-infectious-diseases-introduction-to-mammalian-genome-special-issue-genetics-of-infectious-disease
#9
EDITORIAL
Martin T Ferris, Derek W Hood
No abstract text is available yet for this article.
August 31, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30171338/genetic-mapping-of-a-male-factor-subfertility-locus-on-mouse-chromosome-4
#10
Hideo Gotoh, Ikuo Miura, Shigeharu Wakana
Male reproductive anomalies are widely distributed among mammals, and male factors are estimated to contribute to approximately 50% of cases of human infertility. The B10.M/Sgn (B10.M) mouse strain exhibits two adverse reproductive phenotypes: severe teratospermia and male subfertility. Although teratospermia is known to be heritable, the relationship between teratospermia and male subfertility has not been well characterized. The fertility of B10.M male mice is considerably lower (~ 30%) than that of standard laboratory mouse strains (~ 70%)...
August 31, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30167844/identifying-neoantigens-for-use-in-immunotherapy
#11
REVIEW
Sharon Hutchison, Antonia L Pritchard
This review focuses on the types of cancer antigens that can be recognised by the immune system and form due to alterations in the cancer genome, including cancer testis, overexpressed and neoantigens. Specifically, neoantigens can form when cancer cell-specific mutations occur that result in alterations of the protein from 'self'. This type of antigen can result in an immune response sufficient to clear tumour cells when activated. Furthermore, studies have reported that the likelihood of successful immunotherapeutic targeting of cancer by many different methods was reliant on immune response to neoantigens...
August 24, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30132062/interaction-of-pvr-pvrl2-with-tigit-dnam-1-as-a-novel-immune-checkpoint-axis-and-therapeutic-target-in-cancer
#12
REVIEW
Hauke Stamm, Jasmin Wellbrock, Walter Fiedler
Avoiding immune surveillance and inducing a tumor-promoting inflammatory milieu found entry into the new generation of the hallmarks of cancer. Cancer cells hijack immune mechanisms which physiologically protect the body from the development of autoimmune diseases and excessive tissue damage during inflammation by downregulating immune responses. This is frequently achieved by upregulation of immune checkpoints. Therefore, the blocking of immune checkpoint ligand-receptor interactions can reinstall the immune systems capability to fight cancer cells as shown for CTLA4 and PD-1 inhibitors in a clinical setting...
August 21, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30094508/identification-of-reference-genes-suitable-for-rt-qpcr-studies-of-murine-gastrulation-and-patterning
#13
Kristen S Barratt, Koula E M Diamand, Ruth M Arkell
Quantitative reverse transcriptase PCR (RT-qPCR), a powerful and efficient means of rapidly comparing gene expression between experimental conditions, is routinely used as a phenotyping tool in developmental biology. The accurate comparison of gene expression across multiple embryonic stages requires normalisation to reference genes that have stable expression across the time points to be examined. As the embryo and its constituent tissues undergo rapid growth and differentiation during development, reference genes known to be stable across some time points cannot be assumed to be stable across all developmental stages...
August 9, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30073618/in-silico-mapping-of-quantitative-trait-loci-qtl-regulating-the-milk-ionome-in-mice-identifies-a-milk-iron-locus-on-chromosome-1
#14
Darryl L Hadsell, Louise A Hadsell, Monique Rijnkels, Yareli Carcamo-Bahena, Jerry Wei, Peter Williamson, Michael A Grusak
The breast-feeding neonate depends on mother's milk for both macronutrients and micronutrients including minerals. The goals of the present study were to document the effects of genetic background in mice on milk concentrations of select minerals and to use genome-wide association study (GWAS) to identify quantitative trait loci (QTL) regulating milk mineral concentrations. Milk samples from lactating mice in each of 31 different inbred strains of the mouse diversity panel (MDP) were analyzed by inductively coupled plasma-optical emission spectroscopy to determine the concentrations of calcium (Ca), copper (Cu), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), sulfur (S), and zinc (Zn)...
August 2, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30062485/the-intertwined-fates-of-inflammation-and-coagulation-in-glioma
#15
REVIEW
Angela Cho, Kelly J McKelvey, Adrian Lee, Amanda L Hudson
Inflammation and coagulation are two intertwined pathways with evolutionary ties being traced back to the hemocyte, a single cell type in invertebrates that has functions in both the inflammatory and coagulation pathways. These systems have functioned together throughout evolution to provide a solid defence against infection, damaged cells and irritants. While these systems work in harmony the majority of the time, they can also become dysregulated or corrupted by tumours, enhancing tumour proliferation, invasion, dissemination and survival...
July 30, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30046851/the-role-of-proteomics-in-the-age-of-immunotherapies
#16
REVIEW
Sarah A Hayes, Stephen Clarke, Nick Pavlakis, Viive M Howell
The antigenic landscape of the adaptive immune response is determined by the peptides presented by immune cells. In recent years, a number of immune-based cancer therapies have been shown to induce remarkable clinical responses through the activation of the patient's immune system. As a result, there is a need to identify immune biomarkers capable of predicting clinical response. Recent advances in proteomics have led to considerable developments in the more comprehensive profiling of the immune response. "Immunoproteomics" utilises a rapidly increasing collection of technologies in order to identify and quantify antigenic peptides or proteins...
July 25, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/30008145/heritability-of-the-aged-glutathione-phenotype-is-dependent-on-tissue-of-origin
#17
Rebecca L Gould, Yang Zhou, Claire L Yakaitis, Kimberly Love, Jaxk Reeves, Wenqian Kong, Erica Coe, Yanfang Xiao, Robert Pazdro
Glutathione is a ubiquitous antioxidant that protects cells against reactive oxygen species and other chemical stressors. Despite its functional importance, the impact of genetics on the glutathione system has yet to be fully appreciated. Here, we investigated the heritability of glutathione levels and redox status in a disease-relevant condition: advanced age. We assembled a panel of 18-21-month-old mice representing 19 inbred strains and quantified the levels of reduced and oxidized glutathione, and their sums and ratios, in liver, kidney, heart, pancreas, cerebral cortex, and striatum...
July 14, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29992419/a-mouse-model-of-the-%C3%AE-133p53-isoform-roles-in-cancer-progression-and-inflammation
#18
REVIEW
Marina Kazantseva, Sunali Mehta, Ramona A Eiholzer, Noelyn Hung, Anna Wiles, Tania L Slatter, Antony W Braithwaite
This review paper outlines studies on the Δ122p53 mouse, a model of the human Δ133p53 isoform, together with studies in other model organisms, cell culture, and where available, clinical investigations. In general, these studies imply that, in contrast to the canonical p53 tumor suppressor, Δ133p53 family members have oncogenic capability. Δ122p53 is multi-functional, conferring survival and proliferative advantages on cells, promoting invasion, metastasis and vascularization, as does Δ133p53. Cancers with high levels of Δ133p53 often have poor prognosis...
July 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29987406/manipulating-the-tumor-microenvironment-by-adoptive-cell-transfer-of-car-t-cells
#19
REVIEW
Kavitha Gowrishankar, Lucy Birtwistle, Kenneth Micklethwaite
T-cells expressing synthetic chimeric antigen receptors (CARs) have revolutionized immuno-oncology and highlighted the use of adoptive cell transfer, for the treatment of cancer. The phenomenal clinical success obtained in the treatment of hematological malignancies with CAR T-cells has not been reproduced in the treatment of solid tumors, mainly due to the suppressive and hostile tumor microenvironment (TME). This review will address the immunosuppressive features of the TME, which include the stroma, cytokine and chemokine milieu, suppressive regulatory cells and hypoxic conditions, which can all pose formidable barriers for the effective anti-tumor function of CAR T-cells...
July 9, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29968076/immune-cell-profiling-in-the-age-of-immune-checkpoint-inhibitors-implications-for-biomarker-discovery-and-understanding-of-resistance-mechanisms
#20
REVIEW
Su Yin Lim, Helen Rizos
Immunotherapy has changed the landscape of cancer treatment. The introduction of immune checkpoint inhibitors has seen tremendous success in improving overall survival of patients with advanced metastatic cancers and has now become the standard of care for multiple tumor types. However, efficacy of immune checkpoint blockade appears to be limited to immunogenic cancers, and even amongst immune-reactive cancers, response rates are low and variable between patients. Recent data have also demonstrated the rapid emergence of resistance to immune checkpoint inhibitors, with some patients progressing on treatment within one year...
July 2, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
journal
journal
30620
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"