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International Journal of Risk & Safety in Medicine

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https://www.readbyqxmd.com/read/29865094/paediatric-antidepressants-benefits-and-risks
#1
David Healy, Joanna Le Noury, Jon Jureidini
The data supporting the use of "antidepressants" in children and adolescents is largely unavailable. Academic publications give a different picture as regards benefits and harms to publications from regulatory other sources. Despite disagreements about the data driving use of these medicines, in practice "antidepressants" may now be the most commonly used drugs by adolescent girls, and children's mental health services are attracting increasing attention.This paper reviews the difficulties surrounding the data...
May 25, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29843257/the-monsanto-papers-poisoning-the-scientific-well
#2
Leemon B McHenry
OBJECTIVE: Examination of de-classified Monsanto documents from litigation in order to expose the impact of the company's efforts to influence the reporting of scientific studies related to the safety of the herbicide, glyphosate. METHODS: A set of 141 recently de-classified documents, made public during the course of pending toxic tort litigation, In Re Roundup Products Liability Litigation were examined. RESULTS: The documents reveal Monsanto-sponsored ghostwriting of articles published in toxicology journals and the lay media, interference in the peer review process, behind-the-scenes influence on retraction and the creation of a so-called academic website as a front for the defense of Monsanto products...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29843256/developing-a-model-for-hospital-inherent-safety-assessment-conceptualization-and-validation
#3
Saeed Yari, Hesam Akbari, Mohammad Gholami Fesharaki, Omid Khosravizadeh, Mohammad Ghasemi, Yalda Barsam, Hamed Akbari
BACKGROUND: Paying attention to the safety of hospitals, as the most crucial institute for providing medical and health services wherein a bundle of facilities, equipment, and human resource exist, is of significant importance. OBJECTIVE: The present research aims at developing a model for assessing hospitals' safety based on principles of inherent safety design. METHODS: Face validity (30 experts), content validity (20 experts), construct validity (268 examples), convergent validity, and divergent validity have been employed to validate the prepared questionnaire; and the items analysis, the Cronbach's alpha test, ICC test (to measure reliability of the test), composite reliability coefficient have been used to measure primary reliability...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29843255/underutilization-of-the-reports-of-adverse-events-in-an-argentine-hospital
#4
Fernando Oscar Ramos, Roberto Ariel Abeldaño Zuñiga
BACKGROUND: An adverse event is defined as any unintentional harm that results in temporary or permanent disability and/or prolongation of hospitalization time, or death of a patient; as a consequence of health care provided by any staff member of the health institution. OBJECTIVES: The aim was to describe the adverse events that affect patient safety, reported in 2015 in a private hospital in the city of Córdoba, Argentina. METHODS: We analyzed 678 events reported through the computer system on the hospital's intranet...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29758952/knowledge-and-attitudes-of-patients-in-primary-care-on-off-label-treatment
#5
Mario Ćurković, Dražen Gorjanski
OBJECTIVE: To examine primary care patients' knowledge and attitudes on off-label treatment. METHODS: In 47 primary care offices in Osijek-Baranja County, 1300 patients were given questionnaires about their knowledge and attitudes on off-label treatment. Questionnaires were completed voluntarily and anonymously. RESULTS: Majority of patients (96.3%) had no knowledge about off-label treatment, and upon having it explained, 42.3% would not accept such treatment under any circumstances, while 54...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29758951/ssri-and-snri-withdrawal-symptoms-reported-on-an-internet-forum
#6
Tom Stockmann, Dolapo Odegbaro, Sami Timimi, Joanna Moncrieff
BACKGROUND: Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. OBJECTIVE: We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. METHODS: We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29758950/simulated-medication-errors-a-means-of-evaluating-healthcare-professionals-knowledge-and-understanding-of-medication-safety
#7
Hesty Utami Ramadaniati, Jeffery David Hughes, Ya Ping Lee, Lynne Maree Emmerton
OBJECTIVE: To determine multi-disciplinary perceptions of the clinical significance of medication errors (MEs), the responsible health professional(s), the contributing factors and potential preventive strategies. METHODS: The five simulated ME cases represented errors from five wards at a children's hospital in Australia. Pre-determined answers for each case were developed through consensus among the researchers. The root cause analysis (RCA) was undertaken via a questionnaire disseminated to physicians, nurses and pharmacists at the study hospital to seek their opinions on the ME cases...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29733031/citizen-petition-sexual-side-effects-of-ssris-and-snris
#8
David Healy
No abstract text is available yet for this article.
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29733030/enduring-sexual-dysfunction-after-treatment-with-antidepressants-5%C3%AE-reductase-inhibitors-and-isotretinoin-300-cases
#9
David Healy, Joanna Le Noury, Derelie Mangin
OBJECTIVE: To investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin. METHODS: Data from RxISK.org, a global adverse event reporting website, have been used to establish the clinical features, demographic details and clinical trajectories of syndromes of persistent sexual difficulties following three superficially different treatment modalities.RESULTSWe report on 300 cases of enduring sexual dysfunction from 37 countries following 14 different drugs comprised of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors and isotretinoin...
2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885224/impaired-reproduction-after-exposure-to-adhd-drugs-systematic-review-of-animal-studies
#10
REVIEW
Pia Brandt Danborg, Anders Lykkemark Simonsen, Peter C Gøtzsche
BACKGROUND: Few studies have reported on long-term harms caused by ADHD drugs but they are known to impair growth. OBJECTIVE: To assess whether ADHD drugs impair reproduction in mammals. METHODS: Systematic review of reproduction in studies of animals treated with ADHD drugs. DATA SOURCES: PubMed, Biosis and EMBASE. RESULTS: We included 17 studies. The studies were generally of poor quality or poorly reported...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885223/prescription-audit-of-nsaids-and-gastroprotective-strategy-in-elderly-in-primary-care
#11
Khalid Ahmed Jassim Al Khaja, Sindhan Veeramuthu, Husain Ahmed Isa, Reginald Paul Sequeira
BACKGROUND: The use of non-steroidal anti-inflammatory drug (NSAIDs) is deemed a major risk factor for peptic ulcer disease in elderly population that requires concomitant therapy with gastroprotective agents (GPAs). OBJECTIVE: This study evaluated the rational prescribing of NSAIDs and GPAs, and extent of adherence to the guideline recommendations in primary care. METHODS: Nationwide audit of prescriptions issued to elderly patients (≥65 years) with hypertension or diabetic hypertension in primary care...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885222/opinions-of-maltese-doctors-and-pharmacists-on-medication-errors
#12
Amy Tanti, Miriam Camilleri, Andrew A Borg, Benjamin Micallef, Gavril Flores, Anthony Serracino-Inglott, John Joseph Borg
BACKGROUND: Pharmacovigilance directive 2010/84/EU focused attention on medication errors and encouraged regulators to identify causing and contributing factors. OBJECTIVES: (1) To study opinions of doctors/pharmacists on factors bearing a causal link to MEs as well as ways to minimise MEs (2) to test whether differences in opinion exist between subgroups of doctors and pharmacists working in community, hospital or office settings. METHODS: Different questionnaires were circulated to doctors and pharmacists...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885221/the-establishment-of-the-drug-naming-committee-to-restrict-look-alike-medication-names-in-iran-a-qualitative-study
#13
Nazanin Abolhassani, Ali Akbari Sari, Arash Rashidian, Mansoor Rastegarpanah
BACKGROUND: Medication errors is a prominent issue on the health policy agenda due to its significant human and financial costs; confusing drug names are one of the most common causes of them. This issue necessitates the adoption of a mechanism to restrict such a confusion before approving drug names. OBJECTIVE: Following the establishment of a committee and developed relevant criteria as mechanisms to address the issue of drug names similarity Iran, there were problems in this process...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885220/antidepressants-and-suicide-among-young-women-in-sweden-1999-2013
#14
Jan Larsson
OBJECTIVE: To establish whether the young women (15-24 year old) who committed suicide in Sweden (1999-2013) received antidepressant treatment or not, and to what extent, prior to and/or at the time of suicide. To investigate the belief that increased prescription of antidepressants would drastically reduce the number of suicides. METHODS: An analysis of data from the Swedish Prescribed Drug Register, the Causes of Death Register, with registers cross checked, and from the National Board of Forensic Medicine...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885219/recognition-of-possible-risk-factors-for-clinically-significant-drug-drug-interactions-among-indian-people-living-with-hiv-receiving-highly-active-antiretroviral-therapy-and-concomitant-medications
#15
Poka Siva Sai Lakshmi Priyanka, Danturulu Muralidhar Varma, Kavyasri Immadisetti, Radhakrishnan Rajesh, Sudha Vidyasagar, Vasudeva Guddattu
BACKGROUND: Greatest challenges for clinician is to recognize risk factors for clinically significant drug interactions (CSDIs). There is a lack of awareness about CSDIs among healthcare professionals in India. OBJECTIVE: To recognize all possible risk factors for drug-drug interactions (DDIs) and to identify clinically significant drug interactions (CSDIs), the prevalence, pattern of occurrence of DDIs in People Living with HIV (PLW-HIV) receiving highly active antiretroviral therapy (HAART) and concomitant medications...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885218/off-label-use-of-medicines-the-need-for-good-practice-guidelines
#16
Marc Dooms, James Killick
BACKGROUND: 'Off-label use' is the term used for the prescription and dispensing of a medicinal product for any indication, patient group, route of administration, dosage or treatment regimen other than that listed in the Summary of Product Characteristics. OBJECTIVE: In this article the authors present a brief overview of current practices of off-label use in Europe and the applicable European law and jurisprudence. They then go on to present a set of guidelines for best practice in off-label use which underlines the need for guidance on prescription to be firmly rooted in the need to ensure patient safety above all other concerns...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885217/continuing-medical-education-and-pharmaceutical-industry-involvement-an-evaluation-of-policies-adopted-by-canadian-professional-medical-associations
#17
Adrienne Shnier, Joel Lexchin
BACKGROUND: Professional medical associations (PMAs) play a crucial role in providing accredited continuing medical education (CME) to physicians. Funding from the pharmaceutical industry may lead to biases in CME. OBJECTIVE: This study examines publicly available policies on CME, adopted by Canadian PMAs as of December 2015. METHODS: Policies were evaluated using an original scoring tool comprising 21 items, two questions about PMAs' general and CME funding from industry, and three enforcement measures...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662283/letter-to-the-editor
#18
COMMENT
Hagen Scherb
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662282/letter-to-the-editor
#19
COMMENT
Victor Grech
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662281/letter-to-the-editor
#20
COMMENT
S V Jargin
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
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