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International Journal of Risk & Safety in Medicine

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https://www.readbyqxmd.com/read/29758952/knowledge-and-attitudes-of-patients-in-primary-care-on-off-label-treatment
#1
Mario Ćurković, Dražen Gorjanski
OBJECTIVE: To examine primary care patients' knowledge and attitudes on off-label treatment. METHODS: In 47 primary care offices in Osijek-Baranja County, 1300 patients were given questionnaires about their knowledge and attitudes on off-label treatment. Questionnaires were completed voluntarily and anonymously. RESULTS: Majority of patients (96.3%) had no knowledge about off-label treatment, and upon having it explained, 42.3% would not accept such treatment under any circumstances, while 54...
May 9, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29758951/ssri-and-snri-withdrawal-symptoms-reported-on-an-internet-forum
#2
Tom Stockmann, Dolapo Odegbaro, Sami Timimi, Joanna Moncrieff
BACKGROUND: Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. OBJECTIVE: We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. METHODS: We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms...
May 9, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29758950/simulated-medication-errors-a-means-of-evaluating-healthcare-professionals-knowledge-and-understanding-of-medication-safety
#3
Hesty Utami Ramadaniati, Jeffery David Hughes, Ya Ping Lee, Lynne Maree Emmerton
OBJECTIVE: To determine multi-disciplinary perceptions of the clinical significance of medication errors (MEs), the responsible health professional(s), the contributing factors and potential preventive strategies. METHODS: The five simulated ME cases represented errors from five wards at a children's hospital in Australia. Pre-determined answers for each case were developed through consensus among the researchers. The root cause analysis (RCA) was undertaken via a questionnaire disseminated to physicians, nurses and pharmacists at the study hospital to seek their opinions on the ME cases...
May 9, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29733031/citizen-petition-sexual-side-effects-of-ssris-and-snris
#4
David Healy
No abstract text is available yet for this article.
May 1, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29733030/enduring-sexual-dysfunction-after-treatment-with-antidepressants-5%C3%AE-reductase-inhibitors-and-isotretinoin-300-cases
#5
David Healy, Joanna Le Noury, Derelie Mangin
OBJECTIVE: To investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin. METHODS: Data from RxISK.org, a global adverse event reporting website, have been used to establish the clinical features, demographic details and clinical trajectories of syndromes of persistent sexual difficulties following three superficially different treatment modalities.RESULTSWe report on 300 cases of enduring sexual dysfunction from 37 countries following 14 different drugs comprised of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors and isotretinoin...
May 1, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885224/impaired-reproduction-after-exposure-to-adhd-drugs-systematic-review-of-animal-studies
#6
Pia Brandt Danborg, Anders Lykkemark Simonsen, Peter C Gøtzsche
BACKGROUND: Few studies have reported on long-term harms caused by ADHD drugs but they are known to impair growth. OBJECTIVE: To assess whether ADHD drugs impair reproduction in mammals. METHODS: Systematic review of reproduction in studies of animals treated with ADHD drugs. DATA SOURCES: PubMed, Biosis and EMBASE. RESULTS: We included 17 studies. The studies were generally of poor quality or poorly reported...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885223/prescription-audit-of-nsaids-and-gastroprotective-strategy-in-elderly-in-primary-care
#7
Khalid Ahmed Jassim Al Khaja, Sindhan Veeramuthu, Husain Ahmed Isa, Reginald Paul Sequeira
BACKGROUND: The use of non-steroidal anti-inflammatory drug (NSAIDs) is deemed a major risk factor for peptic ulcer disease in elderly population that requires concomitant therapy with gastroprotective agents (GPAs). OBJECTIVE: This study evaluated the rational prescribing of NSAIDs and GPAs, and extent of adherence to the guideline recommendations in primary care. METHODS: Nationwide audit of prescriptions issued to elderly patients (≥65 years) with hypertension or diabetic hypertension in primary care...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885222/opinions-of-maltese-doctors-and-pharmacists-on-medication-errors
#8
Amy Tanti, Miriam Camilleri, Andrew A Borg, Benjamin Micallef, Gavril Flores, Anthony Serracino-Inglott, John Joseph Borg
BACKGROUND: Pharmacovigilance directive 2010/84/EU focused attention on medication errors and encouraged regulators to identify causing and contributing factors. OBJECTIVES: (1) To study opinions of doctors/pharmacists on factors bearing a causal link to MEs as well as ways to minimise MEs (2) to test whether differences in opinion exist between subgroups of doctors and pharmacists working in community, hospital or office settings. METHODS: Different questionnaires were circulated to doctors and pharmacists...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885221/the-establishment-of-the-drug-naming-committee-to-restrict-look-alike-medication-names-in-iran-a-qualitative-study
#9
Nazanin Abolhassani, Ali Akbari Sari, Arash Rashidian, Mansoor Rastegarpanah
BACKGROUND: Medication errors is a prominent issue on the health policy agenda due to its significant human and financial costs; confusing drug names are one of the most common causes of them. This issue necessitates the adoption of a mechanism to restrict such a confusion before approving drug names. OBJECTIVE: Following the establishment of a committee and developed relevant criteria as mechanisms to address the issue of drug names similarity Iran, there were problems in this process...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885220/antidepressants-and-suicide-among-young-women-in-sweden-1999-2013
#10
Jan Larsson
OBJECTIVE: To establish whether the young women (15-24 year old) who committed suicide in Sweden (1999-2013) received antidepressant treatment or not, and to what extent, prior to and/or at the time of suicide. To investigate the belief that increased prescription of antidepressants would drastically reduce the number of suicides. METHODS: An analysis of data from the Swedish Prescribed Drug Register, the Causes of Death Register, with registers cross checked, and from the National Board of Forensic Medicine...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885219/recognition-of-possible-risk-factors-for-clinically-significant-drug-drug-interactions-among-indian-people-living-with-hiv-receiving-highly-active-antiretroviral-therapy-and-concomitant-medications
#11
Poka Siva Sai Lakshmi Priyanka, Danturulu Muralidhar Varma, Kavyasri Immadisetti, Radhakrishnan Rajesh, Sudha Vidyasagar, Vasudeva Guddattu
BACKGROUND: Greatest challenges for clinician is to recognize risk factors for clinically significant drug interactions (CSDIs). There is a lack of awareness about CSDIs among healthcare professionals in India. OBJECTIVE: To recognize all possible risk factors for drug-drug interactions (DDIs) and to identify clinically significant drug interactions (CSDIs), the prevalence, pattern of occurrence of DDIs in People Living with HIV (PLW-HIV) receiving highly active antiretroviral therapy (HAART) and concomitant medications...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885218/off-label-use-of-medicines-the-need-for-good-practice-guidelines
#12
Marc Dooms, James Killick
BACKGROUND: 'Off-label use' is the term used for the prescription and dispensing of a medicinal product for any indication, patient group, route of administration, dosage or treatment regimen other than that listed in the Summary of Product Characteristics. OBJECTIVE: In this article the authors present a brief overview of current practices of off-label use in Europe and the applicable European law and jurisprudence. They then go on to present a set of guidelines for best practice in off-label use which underlines the need for guidance on prescription to be firmly rooted in the need to ensure patient safety above all other concerns...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28885217/continuing-medical-education-and-pharmaceutical-industry-involvement-an-evaluation-of-policies-adopted-by-canadian-professional-medical-associations
#13
Adrienne Shnier, Joel Lexchin
BACKGROUND: Professional medical associations (PMAs) play a crucial role in providing accredited continuing medical education (CME) to physicians. Funding from the pharmaceutical industry may lead to biases in CME. OBJECTIVE: This study examines publicly available policies on CME, adopted by Canadian PMAs as of December 2015. METHODS: Policies were evaluated using an original scoring tool comprising 21 items, two questions about PMAs' general and CME funding from industry, and three enforcement measures...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662283/letter-to-the-editor
#14
COMMENT
Hagen Scherb
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662282/letter-to-the-editor
#15
COMMENT
Victor Grech
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662281/letter-to-the-editor
#16
COMMENT
S V Jargin
No abstract text is available yet for this article.
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662280/adverse-event-reporting-and-patient-safety-at-a-university-hospital-mapping-correlating-and-associating-events-for-a-data-based-patient-risk-management
#17
Alessandra Buja, Anna Maria Saieva, Angela Vinelli, Rosaria Manola Cacco, Ketty Ottolitri, Elisa De Battisti, Claudio Dario, Vincenzo Baldo
BACKGROUND: Reporting adverse events (AE) with a bearing on patient safety is fundamentally important to the identification and mitigation of potential clinical risks. OBJECTIVE: The aim of this study was to analyze the AE reporting systems adopted at a university hospital for the purpose of enhancing the learning potential afforded by these systems. RESEARCH DESIGN: Retrospective cohort study METHODS: Data were collected from different information flows (reports of incidents and falls, patients' claims and complaints, and cases of hospital-acquired infection [HAI]) at an university hospital...
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662279/study-329-continuation-phase-safety-and-efficacy-of-paroxetine-and-imipramine-in-extended-treatment-of-adolescent-major-depression
#18
RANDOMIZED CONTROLLED TRIAL
Joanna Le Noury, John M Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru, Elia Abi-Jaoude
OBJECTIVE: This is an analysis of the unpublished continuation phase of Study 329, the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The objectives of the continuation phase were to assess safety and relapse rates in the longer term. The objective of this publication, under the Restoring Invisible and Abandoned Trials (RIAT) initiative, was to see whether access to and analysis of the previously unpublished dataset from the continuation phase of this randomized controlled trial would have clinically relevant implications for evidence-based medicine...
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27662278/links-between-serotonin-reuptake-inhibition-during-pregnancy-and-neurodevelopmental-delay-spectrum-disorders-a-systematic-review-of-epidemiological-and-physiological-evidence
#19
REVIEW
D Healy, J Le Noury, D Mangin
OBJECTIVE: To investigate possible linkages between neurodevelopmental delay and neurodevelopmental spectrum disorders and exposure to medication with effects on serotonin reuptake inhibition during pregnancy. METHODS: We systematically reviewed the epidemiological literature for studies bearing on this relationship in children born with neurodevelopmental spectrum disorder and related conditions, as well as animal studies giving serotonin reuptake inhibitors to pregnant animals and in addition reviewed the literature for proposals as to possible mechanisms that might link effects on serotonin reuptake with cognitive changes post-partum...
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27567768/actions-in-response-to-drug-safety-signals%C3%A2-arising-from-a-spontaneous-reporting%C3%A2-system-retrospective-study%C3%A2-in%C3%A2-the%C3%A2-netherlands
#20
Leàn Rolfes, Judith Kolfschoten, Florence van Hunsel, Michel Kooijman, Eugène van Puijenbroek
BACKGROUND: There is limited information on actions taken in response to drug safety signals originating from a spontaneous reporting system (SRS) in pharmacovigilance. In The Netherlands the Pharmacovigilance Centre Lareb is an independent organization that works in close collaboration with the Dutch regulatory agency, the Medicines Evaluation Board (MEB). OBJECTIVE: The objective of this study is to gain insight in steps undertaken on signals originating from the SRS and disseminated by Lareb from 2008-2012...
August 22, 2016: International Journal of Risk & Safety in Medicine
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