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Cerebrovascular Diseases

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https://www.readbyqxmd.com/read/30007980/is-perfusion-mri-without-deconvolution-reliable-for-mismatch-detection-in-acute-stroke-validation-with-15o-positron-emission-tomography
#1
Johanna Reimer, Cornelia Montag, Alexander Schuster, Walter Moeller-Hartmann, Jan Sobesky, Wolf-Dieter Heiss, Olivier Zaro-Weber
BACKGROUND: In acute stroke, the magnetic resonance (MR) imaging-based mismatch concept is used to select patients with tissue at risk of infarction for reperfusion therapies. There is however a controversy if non-deconvolved or deconvolved perfusion weighted (PW) parameter maps perform better in tissue at risk prediction and which parameters and thresholds should be used to guide treatment decisions. METHODS: In a group of 22 acute stroke patients with consecutive MR and quantitative positron emission tomography (PET) imaging, non-deconvolved parameters were validated with the gold standard for penumbral-flow (PF) detection 15O-water PET...
July 13, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29982254/the-impact-of-pregnancy-on-hemorrhagic-stroke-in-young-women
#2
Eliza C Miller, Kathryn M Sundheim, Joshua Z Willey, Amelia K Boehme, Dritan Agalliu, Randolph S Marshall
BACKGROUND: Pregnancy is a sex-specific risk factor for causing hemorrhagic stroke (HS) in young adults. Unique physiological characteristics during pregnancy may alter the relative risk for HS in pregnant/postpartum (PP) women compared to HS in other young women. We compared patient characteristics and HS subtypes between young non-pregnant and PP women. METHODS: We reviewed the medical records of all women 18-45 years old admitted to our center with HS from October 15, 2008 through March 31, 2015, and compared patient characteristics and stroke mechanisms using logistic regression...
July 6, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29982243/cerebrovascular-accident-risk-in-a-population-with-periodic-limb-movements-of-sleep-a-preliminary-meta-analysis
#3
REVIEW
Tzu-Chao Lin, Bing-Yan Zeng, Yen-Wen Chen, Meng-Ni Wu, Tien-Yu Chen, Pao-Yen Lin, Ching-Kuan Wu, Ping-Tao Tseng, Chung-Yao Hsu
BACKGROUND AND PURPOSE: Periodic limb movements of sleep (PLMS) are usually comorbid with hypertension, tachycardia, and coronary arterial diseases, which are also risk factors for cerebrovascular accidents (CVA). However, evidence about the relationship between CVA and PLMS is still weak. The aim of this study was to investigate (1) the prevalence of CVA in patients with PLMS, and (2) the severity of PLMS in patients with or without CVA through a meta-analysis. METHODS: The electronic databases of PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials...
July 6, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29936515/clinical-and-imaging-predictors-of-recurrent-ischemic-stroke-a-systematic-review-and-meta-analysis
#4
REVIEW
Frans Kauw, Richard A P Takx, Hugo W A M de Jong, Birgitta K Velthuis, L Jaap Kappelle, Jan W Dankbaar
BACKGROUND: Predictors of recurrent ischemic stroke are less well known in patients with a recent ischemic stroke than in patients with transient ischemic attack (TIA). We identified clinical and radiological factors for predicting recurrent ischemic stroke in patients with recent ischemic stroke. METHODS: A systematic search in PubMed, Embase, Cochrane Library, and CINAHL was performed with the terms "ischemic stroke," "predictors/determinants," and "recurrence...
June 22, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29898436/endotracheal-intubation-and-in-hospital-mortality-after-intracerebral-hemorrhage
#5
Vasileios-Arsenios Lioutas, Sarah Marchina, Louis R Caplan, Magdy Selim, Joseph Tarsia, Luciana Catanese, Jonathan Edlow, Sandeep Kumar
BACKGROUND: Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation with subsequent mechanical ventilation (MV) for "airway protection" with the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, and adversely affect patient outcomes. The net benefit of intubation and MV in this patient cohort has not been systematically investigated...
June 13, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29879716/low-morbidity-after-extracranial-intracranial-bypass-operation-the-danish-extracranial-intracranial-bypass-study-a-nationwide-survey
#6
Paul von Weitzel-Mudersbach, Grethe Andersen, Sverre Rosenbaum
BACKGROUND: Patients with symptomatic atherosclerotic carotid artery occlusion (SACAO) have a high risk of a recurrent stroke. Extracranial-intracranial bypass (EC-IC bypass) has been shown not to improve outcome compared with medical treatment alone because long-term prevention of recurrent stroke in operated patients was offset by high perioperative stroke rates. We report our experience with EC-IC bypass operated at an experienced high-volume centre. METHODS: We conducted a nationwide observational study of EC-IC bypass patients operated in the years 2007-2016 due to SACAO with ongoing clinical symptoms or progression on MRI and severe haemodynamic failure (SHF)...
June 7, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29879697/flip-flop-phenomenon-swallowing-induced-arterial-displacement-as-an-indicator-of-carotid-artery-disease
#7
Naoto Kinoshita, Kozue Saito, Yoshitaka Yamaguchi, Soichiro Abe, Shinichi Wada, Tomotaka Tanaka, Katsufumi Kajimoto, Hiroshi Yamagami, Hirofumi Maruyama, Kazunori Toyoda, Masafumi Ihara, Kazuyuki Nagatsuka
BACKGROUND AND PURPOSE: The dynamic displacement of the carotid arteries with interference of the hyoid bone during swallowing, named as "flip-flop" phenomenon (FFP), may be associated with ischemic stroke. However, the extent to which FFP is prevalent in carotid artery disease remains unknown. We aimed to investigate its exact prevalence to explore the relationship between FFP and carotid artery disease. METHODS: We examined 202 consecutive patients who were affected by neurological diseases including cerebrovascular diseases...
June 7, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29879696/tenacity-of-collateral-perfusion-in-proximal-cerebral-arterial-occlusions-6-12-h-after-onset
#8
Beom Joon Kim, Hyeran Kim, Han-Gil Jeong, Mi Hwa Yang, Cheol Kyu Jung, Moon-Ku Han, Jae Hyoung Kim, Andrew M Demchuk, Hee-Joon Bae
BACKGROUND: Clinical trials have shown that benefits of endovascular recanalization (EVT) for acute ischemic stroke patients with sizable penumbral tissues seems plausible even beyond 6 h after their last seen normal (LSN). Persistency of ischemic penumbra remains unclear in delayed periods. METHODS: From a prospective stroke registry database, we identified 111 acute ischemic stroke patients who had internal carotid artery or middle cerebral artery occlusion with baseline National Institutes of Health Stroke Scale scores ≥6 points and arrived 6-12 h after LSN...
June 7, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29843148/target-door-to-needle-time-for-tissue-plasminogen-activator-treatment-with-magnetic-resonance-imaging-screening-can-be-reduced-to-45-min
#9
Denis Sablot, Ioana Ion, Khaled Khlifa, Geoffroy Farouil, Franck Leibinger, Nicolas Gaillard, Alexandre Laverdure, Zoubir Mourad Bensalah, Julie Mas, Bénédicte Fadat, Philippe Smadja, Adélaïde Ferraro-Allou, Jean-Marie Bonnec, Nadège Olivier, Anaïs Dutray, Maxime Tardieu, Adrian Dumitrana, Aymeric Guibal, Snejana Jurici, Jean-Louis Bertrand, Thibaut Allou, Caroline Arquizan, Alain Bonafe
OBJECTIVE: The purpose of this study was to demonstrate that the median door-to-needle (DTN) time for intravenous tissue plasminogen activator (tPA) treatment can be reduced to 45 min in a primary stroke centre with MRI-based screening for acute ischaemic stroke (AIS). METHODS: From February 2015 to February 2017, the stroke unit of Perpignan general hospital, France, implemented a quality-improvement (QI) process. During this period, patients who received tPA within 4...
May 29, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29772576/wake-up-stroke-versus-stroke-with-known-onset-time-clinical-and-multimodality-ct-imaging-characteristics
#10
Jan W Dankbaar, Henri P Bienfait, Coen van den Berg, Edwin Bennink, Alexander D Horsch, Tom van Seeters, Irene C van der Schaaf, L Jaap Kappelle, Birgitta K Velthuis
BACKGROUND: Current guidelines for the treatment of acute ischemic stroke are mainly based on the time between symptom onset and initiation of treatment. This time is unknown in patients with wake-up stroke (WUS). We investigated clinical and multimodality CT imaging characteristics on admission in patients with WUS and in patients with a stroke with a known onset time. METHODS: All patients were selected from a large prospective cohort study (Dutch acute stroke study)...
May 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29772570/undertreatment-of-vascular-risk-factors-in-patients-with-monocular-ischaemic-visual-loss
#11
Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva
BACKGROUND AND PURPOSE: Ischaemic visual loss is often considered a lower risk factor than other transient ischaemic attacks (TIA). We aimed to determine the recurrence risk, prevalence and management of vascular risk factors in these patients. METHODS: The study took place in the University College Hospital London daily TIA clinic, main referral centre for North-Central London and Moorfields Eye Hospital. Consecutive records for patients with transient (< 24 h) or permanent (> 24 h) ischaemic visual loss were reviewed during the period January 2014-October 2016...
May 17, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29763889/neutrophil-lymphocyte-ratio-predicts-functional-and-safety-outcomes-after-endovascular-treatment-for-acute-ischemic-stroke
#12
Zhenhui Duan, Huaiming Wang, Zhen Wang, Yonggang Hao, Wenjie Zi, Dong Yang, Zhiming Zhou, Wenhua Liu, Min Lin, Zhonghua Shi, Penghua Lv, Yue Wan, Gelin Xu, Yunyun Xiong, Wusheng Zhu, Xinfeng Liu
BACKGROUND AND OBJECTIVE: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. METHODS: Patients were selected from the EVT for acUte Anterior circuLation (ACTUAL) ischemic stroke registry...
May 15, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29705803/lipid-lowering-pretreatment-and-outcome-following-intravenous-thrombolysis-for-acute-ischaemic-stroke-a-post-hoc-analysis-of-the-enhanced-control-of-hypertension-and-thrombolysis-stroke-study-trial
#13
Jatinder S Minhas, Xia Wang, Hisatomi Arima, Philip M Bath, Laurent Billot, Joseph P Broderick, Geoffrey A Donnan, Jong S Kim, Pablo M Lavados, Tsong-Hai Lee, Sheila Cristina Ouriques Martins, Verónica V Olavarría, Jeyaraj D Pandian, Octávio Marques Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K Sharma, Nguyen H Thang, Ji-Guang Wang, Mark Woodward, John Chalmers, Craig S Anderson, Thompson G Robinson
BACKGROUND: Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup -analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study. METHODS: In all, 3,284 thrombolysis-eligible AIS patients (mean age 66...
April 27, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29649819/patent-foramen-ovale-and-cryptogenic-stroke-or-transient-ischemic-attack-to-close-or-not-to-close-a-systematic-review-and-meta-analysis
#14
Simona Lattanzi, Francesco Brigo, Claudia Cagnetti, Mario Di Napoli, Mauro Silvestrini
BACKGROUND: The optimal strategy of secondary stroke prevention in patients with patent foramen ovale (PFO) is controversial. This study was performed to evaluate the efficacy and safety of the device closure (DC) versus the medical therapy (MT) in patients with cryptogenic stroke or transient ischemic attack (TIA) and PFO. SUMMARY: Randomized controlled trials with active and control groups receiving the DC plus MT and MT alone in patients with history of cryptogenic stroke/TIA and diagnosis of PFO were systematically searched...
April 12, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29627835/diagnosis-of-hyperacute-and-acute-ischaemic-stroke-the-potential-utility-of-exosomal-microrna-21-5p-and-microrna-30a-5p
#15
Wei Wang, Dong-Bin Li, Ru-Ying Li, Xia Zhou, Dong-Ju Yu, Xiao-Yan Lan, Jin-Pin Li, Jing-Li Liu
BACKGROUND: Early and accurate diagnosis of ischaemic stroke (IS) requires the use of an optimized biomarker. Exosomal microRNAs have the potential to serve as biomarkers owing to their stability and specificity. We investigated the expression levels of plasma-derived exosomal microRNA-21-5p and microRNA-30a-5p in the different phases of IS. METHODS: One hundred forty-three patients with IS and 24 non-stroke controls were enrolled. The patients were divided into the following 5 groups: 1 group for the hyperacute phase IS (HIS, within 6 h); two for the acute phase IS (AIS, including days 1-3 and days 4-7); one for the subacute phase IS (SIS, days 8-14); and one for the recovery phase IS (RIS, days >14)...
April 6, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29698939/synergistic-strategies-to-promote-stroke-research
#16
Michael G Hennerici
No abstract text is available yet for this article.
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29614501/the-serotonin-transporter-gene-polymorphisms-and-risk-of-ischemic-stroke
#17
Janne Kaergaard Mortensen, Kristian Lundsgaard Kraglund, Søren Paaske Johnsen, Ole Mors, Grethe Andersen, Henriette N Buttenschøn
INTRODUCTION: Serotonin is known as a neurotransmitter; however, it also plays an important role in platelet aggregation as it is released upon platelet activation. The serotonin transporter (SERT) is responsible for the uptake of serotonin into platelets. Functional polymorphisms in the SERT gene may influence platelet activity, as they result in different levels of transporters and thereby different levels of serotonin in platelets. SERT gene polymorphisms have thus been associated with the risk of myocardial infarction...
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29614486/prevention-effect-of-antiplatelets-on-aneurysm-rupture-in-a-mouse-intracranial-aneurysm-model
#18
Tomo Suzuki, Yoshinobu Kamio, Hiroshi Makino, Kazuya Hokamura, Tetsuro Kimura, Tomohiro Yamasaki, Hisaya Hiramatsu, Kazuo Umemura, Hiroki Namba
BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) from intracranial aneurysm rupture results in significant morbidity and mortality. In the present study, we examined the effect of most widely used antiplatelet drugs, aspirin and cilostazol, on aneurysm rupture prevention using a mouse intracranial aneurysm model. MATERIALS AND METHODS: Intracranial aneurysms were induced by a combination of deoxycorticosterone acetate-salt and a single injection of elastase into the cerebrospinal fluid in mice...
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29597211/associations-between-pre-admission-risk-scores-and-two-year-clinical-outcomes-in-ischemic-stroke-or-transient-ischemic-attack-patients-with-non-valvular-atrial-fibrillation
#19
Keisuke Tokunaga, Hiroshi Yamagami, Masatoshi Koga, Kenichi Todo, Kazumi Kimura, Ryo Itabashi, Tadashi Terasaki, Yoshiaki Shiokawa, Kenji Kamiyama, Shunya Takizawa, Satoshi Okuda, Yasushi Okada, Tomoaki Kameda, Yoshinari Nagakane, Yasuhiro Hasegawa, Satoshi Shibuya, Yasuhiro Ito, Hideki Matsuoka, Kazuhiro Takamatsu, Kazutoshi Nishiyama, Kazuomi Kario, Yoshiki Yagita, Takanari Kitazono, Naoto Kinoshita, Junji Takasugi, Takuya Okata, Sohei Yoshimura, Shoichiro Sato, Shoji Arihiro, Kazunori Toyoda
BACKGROUND: We aimed to clarify associations between pre-admission risk scores (CHADS2, CHA2DS2-VASc, and HAS-BLED) and 2-year clinical outcomes in ischemic stroke or transient ischemic attack (TIA) patients with non-valvular atrial fibrillation (NVAF) using a prospective, multicenter, observational registry. METHODS: From 18 Japanese stroke centers, ischemic stroke or TIA patients with NVAF hospitalized within 7 days after onset were enrolled. Outcome measures were defined as death/disability (modified Rankin Scale score ≥3) at 2 years, 2-year mortality, and ischemic or hemorrhagic events within 2 years...
2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29597192/transcatheter-closure-of-patent-foramen-ovale-versus-medical-therapy-after-cryptogenic-stroke-a-meta-analysis-of-randomized-controlled-trials
#20
Fahed Darmoch, Yasser Al-Khadra, Mohamad Soud, Zaher Fanari, M Chadi Alraies
BACKGROUND: Patent foramen ovale (PFO) with atrial septal aneurysm is suggested as an important potential source for cryptogenic strokes. Percutaneous PFO closure to reduce the recurrence of stroke compared to medical therapy has been intensely debated. The aim of this study is to assess whether PFO closure in patients with cryptogenic stroke is safe and effective compared with medical therapy. METHOD: A search of PubMed, Medline, and Cochrane Central Register from January 2000 through September 2017 for randomized controlled trails (RCT), which compared PFO closure to medical therapy in patients with cryptogenic stroke was conducted...
2018: Cerebrovascular Diseases
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