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Cerebrovascular Diseases

Jun Young Chang, Sang Beom Jeon, Jung Hwa Lee, O-Ki Kwon, Moon-Ku Han
BACKGROUND: Blood pressure variability (BPV) is associated with target organ damage progression and increased cardiovascular events, including stroke. The aim of this study was to evaluate the associations between short-term BPV during acute periods and recanalization degree, early neurological deterioration (END) occurrence, and functional outcomes in acute ischemic stroke patients who had undergone intra-arterial thrombectomy (IAT). METHODS: We retrospectively analyzed 303 patients with large vessel occlusive stroke who underwent IAT...
January 15, 2019: Cerebrovascular Diseases
Takaaki Amamoto, Noriyuki Sakata, Toshiyasu Ogata, Hirofumi Shimada, Tooru Inoue
BACKGROUND AND PURPOSE: Although the echogenicity of carotid plaques on carotid enhanced ultrasound (CEUS) was reported to correlate with the historological density of intra-plaque neovessels, it is unclear whether the intra-plaque vessel size is associated with carotid plaque vulnerability. We evaluated the relationship of size of intra-plaque vessels on CEUS with carotid plaque histology. METHODS: We prospectively registered patients with carotid stenosis who were hospitalized to receive carotid endarterectomy between 2012 and 2016...
January 15, 2019: Cerebrovascular Diseases
Jonathan Kottlors, Volker Maus, Anastasios Mpotsaris, Özgür A Onur, Thomas Liebig, Christoph Kabbasch, Jan Borggrefe
BACKGROUND: Ex vivo computed tomography (CT) studies of artificial blood thrombi showed that contrast enhancement (CE) is determined by fibrin-content, while unenhanced density is associated with red blood cells. Thus, the present study investigates patient outcome in association with combined thrombus density measures in native and contrast-enhanced CT (CECT) of acute ischemic stroke patients. METHODS: This retrospective study includes 137 patients with M1 occlusions treated by mechanical thrombectomy (MT) between 2010 and 2016...
January 15, 2019: Cerebrovascular Diseases
Gustavo C Santo, Inês Baldeiras, Rita Guerreiro, Joana A Ribeiro, Rosário Cunha, Taryn Youngstein, Sira Nanthapisal, João Leitão, Carolina Fernandes, Francisco Caramelo, Maria do Rosário Almeida, José Brás, Isabel Santana
BACKGROUND: The association that exists between livedo reticularis (LR) and stroke is known as Sneddon's syndrome (SnS). The disorder is classified as primary SnS (PSnS), if the cause remains unknown and secondary SnS. The condition is rare and it occurs mainly sporadically. In 2014, 2 independent teams described a new genetic disorder with childhood-onset, which was called deficiency of adenosine deaminase 2 (DADA2), characterized by recurrent fevers and vascular pathologic features that included LR and stroke...
January 15, 2019: Cerebrovascular Diseases
Kota Maekawa, Masunari Shibata, Hideki Nakajima, Yotaro Kitano, Masaru Seguchi, Kazuto Kobayashi, Takanori Sano, Tadashi Yabana, Fumitaka Miya
OBJECT: We investigated possible associations among the presence of cholesterol crystals in embolic debris, the proportions of debris components, and postoperative cerebral embolism in patients undergoing carotid artery stenting (CAS). METHODS: Sixty-seven consecutive procedures were performed for internal carotid artery stenosis with CAS at our hospital between November 2015 and February 2018. Procedures for emergency CAS for stroke in evolution or crescendo transient ischemic attack were excluded (n = 12)...
January 2, 2019: Cerebrovascular Diseases
Yaowaree Leavell, Mian Khalid, Stanley Tuhrim, Mandip S Dhamoon
BACKGROUND: There are limited epidemiologic data on cerebral venous sinus thrombosis (CVST). We aim to summarize baseline characteristics and outcomes using a large nationally representative administrative database. METHODS: Using the 2013 Nationwide Readmissions Database, we used validated International Classification of Disease, Ninth Revision codes to identify baseline characteristics of patients admitted with CVST. We calculated readmission rates (per 100,000 index hospitalizations) for neurological complications...
January 2, 2019: Cerebrovascular Diseases
Mateusz K Hołda, Mateusz Koziej
BACKGROUND: Despite some evidence of left-sided septal pouch (LSSP) involvement in the pathogenesis of cardioembolic stroke, the question of LSSP clinical significance still remains unsolved. In this study, we aimed to determine the association between the LSSP presence and cryptogenic stroke using meta-analytical approach. METHODS: We performed a systematic review of electronic databases for studies that compared the presence of LSSP in subjects with cryptogenic stroke and non-stroke control...
December 5, 2018: Cerebrovascular Diseases
Alexander J Martin, Christopher I Price
BACKGROUND: Early neurological deterioration (END) following acute stroke is associated with poorer long-term outcomes. Identification of patients at risk could assist early monitoring and treatment decisions. This review summarised the evidence describing non-radiological biomarkers for END. SUMMARY: Electronic searches from January 1990 to March 2017 identified studies reporting a blood/cerebrospinal fluid (CSF)/urine biomarker measurement within 24 h of acute stroke and at least 2 serial assessments of clinical neurological status (< 24 h and < 7 days)...
December 5, 2018: Cerebrovascular Diseases
Ilana E Green, Shareena A Rahman, Debra L Owens, Michèle M Sale, Lillian J Currie, Keith L Keene, Bradford B Worrall, Andrew M Southerland
BACKGROUND AND PURPOSE: The majority of published data in cervical artery dissection (CeAD), a common cause of stroke in young adults, derive from populations of European ancestry (EA), including a recent genome-wide study identifying an association with the rs9349379 polymorphism of the PHACTR1 gene. Little is known about CeAD in individuals of African ancestry (AA) despite robust epidemiological data showing increased risk of stroke at younger ages. We hypothesize that AA patients with CeAD have different epidemiology and clinical profiles compared to those of EA, and a different genetic architecture related to rs9349379 of the PHACTR1 gene...
December 5, 2018: Cerebrovascular Diseases
Cory J Rice, Sung-Min Cho, Lucy Q Zhang, Catherine Hassett, Randall C Starling, Ken Uchino
BACKGROUND: Ischemic and hemorrhagic strokes are frequent complications among those with left ventricular assist device (LVAD). Scarce data exist regarding the prevalence of acute large vessel occlusion (LVO) and treatment of acute ischemic stroke (AIS) in this setting. METHODS: We reviewed prospectively collected data of LVAD patient registry from a single, tertiary center from October 2004 to November 2016. Among those with AIS complications, patients were divided into early stroke (during implantation hospitalization) and late stroke (post-discharge) groups, and neuroimaging was reviewed and data on acute stroke therapy were collected...
December 4, 2018: Cerebrovascular Diseases
Volker Maus, Utako Birgit Barnikol, Anastasios Mpotsaris
No abstract text is available yet for this article.
November 12, 2018: Cerebrovascular Diseases
Eun-Jae Lee, Cheol-Hyun Chung, Kyoung-Hyo Choi, Jae-Won Lee, Suk-Jung Choo, Sung-Ho Jung, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND: In the previous prospective observational study, we found that cerebral atherosclerosis is an independent predictor of acute stroke after coronary artery bypass grafting (CABG). However, it is unknown whether intracranial cerebral atherosclerosis (ICAS) is important as much as extracranial cerebral atherosclerosis (ECAS) in estimating the risk of post-CABG adverse events. Extending the previous study, we aimed to investigate the immediate and long-term prognostic value of the location of cerebral atherosclerosis in CABG patients...
November 8, 2018: Cerebrovascular Diseases
John W P Wong, Leonid Churilov, Richard Dowling, Peter Mitchell, Steven Bush, Lasheta Kanesan, Bernard Yan
BACKGROUND/AIM: Endovascular thrombectomy may be performed in anticoagulated patients taking vitamin-K antagonists (VKA) or direct-acting oral anticoagulants (DOAC) in whom the use of intravenous tissue plasminogen activator (tPA) is contraindicated. We aimed to investigate the efficacy and safety of mechanical thrombectomy specifically in anticoagulated patients ineligible for thrombolysis. METHODS: We performed a retrospective analysis of a prospectively collected database of consecutive ischaemic stroke patients undergoing mechanical thrombectomy from January 2008 to June 2017...
November 1, 2018: Cerebrovascular Diseases
(no author information available yet)
No abstract text is available yet for this article.
September 4, 2018: Cerebrovascular Diseases
Michael G Hennerici
No abstract text is available yet for this article.
2018: Cerebrovascular Diseases
Junichiro Suzuki, Noriyoshi Nakai, Naohide Kondo, Hirotake Tsuji, Ryosuke Inagaki, Soma Furukawa, Mai Iwata, Suguru Nishida, Yasuhiro Ito
BACKGROUND: Emergency medical services are an important part of acute stroke management. We devised a prehospital stroke scale, the TOYOTA prehospital stroke scale for tissue plasminogen activator (t-PA) intravenous therapy (TOPSPIN) for triaging patients with ischemic stroke and especial indications for intravenous t-PA therapy in December 2006; this scale comprises 5 items including consciousness, atrial fibrillation, language disorder, disturbance of the upper extremities, and disturbance of the lower extremities...
2018: Cerebrovascular Diseases
Ana Dionísio, Isabel Catarina Duarte, Miguel Patrício, Miguel Castelo-Branco
BACKGROUND: Following a stroke event, patients often are severely affected by disabilities that hinder their quality-of-life. There are currently several rehabilitative options and strategies, and it is crucial to find the most effective interventions. The applicability of transcranial magnetic stimulation (TMS) to the recovery of nonmotor functions such as communication skills, swallowing ability and spatial attention after stroke remains important clinical questions. SUMMARY: We searched PubMed and ISI Web of Science for articles that used repetitive TMS protocols to rehabilitate post-stroke deficits...
2018: Cerebrovascular Diseases
Penelope van Veenendaal, Bernard Yan, Leonid Churilov, Richard Dowling, Steven Bush, Peter Mitchell
BACKGROUND: Endovascular clot retrieval (ECR) improves outcomes for acute ischaemic stroke with large artery occlusion. However, the provision of ECR requires resource-intensive comprehensive stroke centres (CSC), which are impractical to establish in regional hospitals. An alternative is a "hub-and-spoke" model, whereby ischaemic strokes are triaged at the regional primary centres and where eligible, transferred to a CSC. We aimed to compare the outcomes of patients directly admitted to a CSC with patients treated in the "hub-and-spoke" model...
2018: Cerebrovascular Diseases
Joshua A Cuoco, Christopher M Busch, Brendan J Klein, Michael J Benko, Rachel Stein, Andrew D Nicholson, Eric A Marvin
BACKGROUND: Missense mutations in the gene that codes for smooth muscle actin, ACTA2, cause diffuse smooth muscle dysfunction and a distinct cerebral arteriopathy collectively known as multisystemic smooth muscle dysfunction syndrome (MSMDS). Until recently, ACTA2 cerebral arteriopathy was considered to be a variant of moyamoya disease. However, recent basic science and clinical data have demonstrated that the cerebral arteriopathy caused by mutant ACTA2 exhibits genetic loci, histopathology, neurological sequelae, and radiographic findings unique from moyamoya disease...
2018: Cerebrovascular Diseases
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