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Cerebrovascular Diseases

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https://www.readbyqxmd.com/read/27898402/recent-update-on-carotid-endarterectomy-versus-carotid-artery-stenting
#1
Raywat Noiphithak, Anusak Liengudom
Carotid artery stenosis (CS) is a major cause of ischemic stroke. Treatment of CS consists of best medical treatment and carotid revascularization (CR), including carotid endarterectomy (CEA) and carotid artery stenting (CAS). Both CR techniques have their own procedural risks. Therefore, selection of the appropriate treatment for patients with CS is relatively complicated. Many studies and guidelines have reported the efficacy of each treatment for both symptomatic and asymptomatic patients. However, the results are still controversial, especially concerning the efficacy and safety of CEA and CAS...
November 30, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27871078/cerebral-microhemorrhages-and-meningeal-siderosis-in-infective-endocarditis
#2
Ajay Malhotra, Joseph Schindler, Brian Mac Grory, Stacy Y Chu, Teddy S Youn, Charles Matouk, David M Greer, Matthew Schrag
OBJECTIVE: Patients with infective endocarditis (IE) frequently experience cerebral insults, and neurological involvement in IE has been reported to herald a worse prognosis. In this manuscript, we describe a distinctive pattern of findings on susceptibility-weighted imaging (SWI) sequences in subjects with IE. METHODS: Patients with IE who underwent SWI MRI at an academic hospital from 2009 to 2014 were retrospectively analyzed. The pattern of findings was compared to SWI findings in groups of subjects with cerebral amyloid angiopathy (CAA) or severe hypertension...
November 22, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27866207/post-stroke-fatigue-may-be-associated-with-the-promoter-region-of-a-monoamine-oxidase-a-gene-polymorphism
#3
Smi Choi-Kwon, Mihye Ko, Sang-Eun Jun, Juhan Kim, Kyung-Hee Cho, Hyun-Wook Nah, Hasup Song, Jong S Kim
BACKGROUND: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. METHODS: A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A)...
November 19, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27846631/prognostic-factors-and-pattern-of-long-term-recovery-with-mlc601-neuroaid%C3%A2-in-the-chinese-medicine-neuroaid-efficacy-on-stroke-recovery-extension-study
#4
Narayanaswamy Venketasubramanian, Chun Fan Lee, Sherry H Young, San San Tay, Thirugnanam Umapathi, Annabelle Y Lao, Herminigildo H Gan, Alejandro C Baroque Ii, Jose C Navarro, Hui Meng Chang, Joel M Advincula, Sombat Muengtaweepongsa, Bernard P L Chan, Carlos L Chua, Nirmala Wijekoon, H Asita de Silva, John Harold B Hiyadan, Nijasri C Suwanwela, K S Lawrence Wong, Niphon Poungvarin, Gaik Bee Eow, Christopher L H Chen
BACKGROUND: The Chinese Medicine NeuroAiD Efficacy on Stroke recovery - Extension (CHIMES-E) study is among the few acute stroke trials with long-term outcome data. We aimed to evaluate the recovery pattern and the influence of prognostic factors on treatment effect of MLC601 over 2 years. METHODS: The CHIMES-E study evaluated the 2 years outcome of subjects aged ≥18 years with acute ischemic stroke, National Institutes of Health Stroke Scale (NIHSS) score 6-14, pre-stroke modified Rankin Scale (mRS) score ≤1 included in a multicenter, randomized, double-blind, placebo-controlled trial of MLC601 for 3 months...
November 15, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27842319/designated-stroke-center-status-and-hospital-characteristics-as-predictors-of-in-hospital-mortality-among-hemorrhagic-stroke-patients-in-new-york-2008-2012
#5
Hajere J Gatollari, Anna Colello, Bonnie Eisenberg, Ian Brissette, Jorge Luna, Mitchell S V Elkind, Joshua Z Willey
BACKGROUND: Although designated stroke centers (DSCs) improve the quality of care and clinical outcomes for ischemic stroke patients, less is known about the benefits of DSCs for patients with intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH). HYPOTHESIS: Compared to non-DSCs, hospitals with the DSC status have lower in-hospital mortality rates for hemorrhagic stroke patients. We believed these effects would sustain over a period of time after adjusting for hospital-level characteristics, including hospital size, urban location, and teaching status...
November 15, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27820930/is-there-benefit-from-stenting-on-cognitive-function-in-intracranial-atherosclerosis
#6
Tanya N Turan, Alison Smock, George Cotsonis, David Bachman, Sami Al Kasab, Michael J Lynn, Azhar Nizham, Collin P Derdeyn, David Fiorella, Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
BACKGROUND: Revascularization of stenotic cerebral arteries is hypothesized to improve cognition by increasing cerebral perfusion. AIMS: We compared cognition impairment among patients treated with percutaneous angioplasty and stenting (PTAS) and aggressive medical management (AMM) versus AMM alone in the Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) Trial. METHODS: In SAMMPRIS, 451 patients with recent transient ischemic attack or stroke attributed to 70-99% intracranial stenosis were randomized to PTAS plus AMM or AMM alone...
November 5, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27750252/optimized-flat-detector-ct-in-stroke-imaging-ready-for-first-line-use
#7
Matthias Eckert, Philipp Gölitz, Hannes Lücking, Tobias Struffert, Frauke Knossalla, Arnd Doerfler
BACKGROUND: Using flat-detector CT (FD-CT) for stroke imaging has the advantage that both diagnostic imaging and endovascular therapy can be performed directly within the Angio Suite without any patient transfer and time delay. Thus, stroke management could be speeded up significantly, and patient outcome might be improved. But as precondition for using FD-CT as primary imaging modality, a reliable exclusion of intracranial hemorrhage (ICH) has to be possible. This study aimed to investigate whether optimized native FD-CT, using a newly implemented reconstruction algorithm, may reliably detect ICH in stroke patients...
October 18, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27750251/white-matter-hyperintensities-improve-ischemic-stroke-recurrence-prediction
#8
Søren Due Andersen, Torben Bjerregaard Larsen, Anders Gorst-Rasmussen, Yousef Yavarian, Gregory Y H Lip, Flemming W Bach
BACKGROUND: Nearly one in 5 patients with ischemic stroke will invariably experience a second stroke within 5 years. Stroke risk stratification schemes based solely on clinical variables perform only modestly in non-atrial fibrillation (AF) patients and improvement of these schemes will enhance their clinical utility. Cerebral white matter hyperintensities are associated with an increased risk of incident ischemic stroke in the general population, whereas their association with the risk of ischemic stroke recurrence is more ambiguous...
October 18, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27750246/the-course-of-activities-in-daily-living-who-is-at-risk-for-decline-after-first-ever-stroke
#9
Roderick Wondergem, Martijn F Pisters, Eveline J Wouters, Nick Olthof, Rob A de Bie, Johanna M A Visser-Meily, Cindy Veenhof
BACKGROUND: Stroke is not only an acute disease, but for the majority of patients, it also becomes a chronic condition. There is a major concern about the long-term follow-up with respect to activities of daily living (ADL) in stroke survivors. Some patients seem to be at risk for decline after a first-ever stroke. The purpose of this study was to determine the course of ADL from 3 months after the first-ever stroke and onward and identify factors associated with decline in ADL. METHODS: A systematic literature search of 3 electronic databases through June 2015 was conducted...
October 18, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27750222/long-term-risk-of-stroke-after-transient-ischemic-attack
#10
Peter Appelros, Maria Háls Berglund, Jakob O Ström
BACKGROUND: In the absence of active management, the stroke risk after a transient ischemic attack (TIA) may be high. Almost 10 years ago, the results of the EXPRESS and SOS-TIA studies called for a more rapid management of TIA patients. The purpose of this study was to investigate the other stroke risks in the longer term, after the implementation of a more active approach to TIA. We also wanted to assess the predictive value of the ABCD2 score in this context. METHODS: Riksstroke is the national stroke registry in Sweden...
October 18, 2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27788501/editorial
#11
Michael G Hennerici, Marc Fatar
No abstract text is available yet for this article.
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27701170/pre-stroke-use-of-beta-blockers-does-not-lower-post-stroke-infection-rate-an-exploratory-analysis-of-the-preventive-antibiotics-in-stroke-study
#12
Willeke F Westendorp, Jan-Dirk Vermeij, Matthijs C Brouwer, Y B W E M Roos, Paul J Nederkoorn, Diederik van de Beek
BACKGROUND: Stroke-associated infections occur frequently and are associated with unfavorable outcome. Previous cohort studies suggest a protective effect of beta-blockers (BBs) against infections. A sympathetic drive may increase immune suppression and infections. AIM: This study is aimed at investigating the association between BB treatment at baseline and post-stroke infection in the Preventive Antibiotics in Stroke Study (PASS), a prospective clinical trial...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27598469/interdisciplinary-treatment-of-intracranial-infectious-aneurysms
#13
Christina A Hamisch, Anastasios Mpotsaris, Marco Timmer, Michael Reiner, Pantelis Stavrinou, Gerrit Brinker, Roland Goldbrunner, Boris Krischek
OBJECTIVE: Intracranial infectious aneurysms (IIAs) are a rare clinical entity without a definitive treatment guideline. In this study, we evaluate the treatment options of these lesions based on our own clinical experience and review the current knowledge of therapy as portrayed in the literature. METHODS: We conducted a single-center retrospective analysis of all patients with an IIA and performed a systematic review of the literature using the MEDLINE database...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27595266/the-effect-of-age-on-characteristics-and-mortality-of-intracerebral-hemorrhage-in-the-oldest-old
#14
Paola Forti, Fabiola Maioli, Michele Domenico Spampinato, Carlotta Barbara, Valeria Nativio, Maura Coveri, Marco Zoli, Luigi Simonetti, Giuseppe Di Pasquale, Gaetano Procaccianti
BACKGROUND: Incidence of acute intracerebral hemorrhage (ICH) increases with age, but there is a lack of information about ICH characteristics in the oldest-old (age ≥85 years). In particular, there is a need for information about hematoma volume, which is included in most clinical scales for prediction of mortality in ICH patients. Many of these scales also assume that, independent of ICH characteristics, the oldest-old have a higher mortality than younger elderly patients (age 65-74 years)...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27578358/characterization-of-clinical-and-radiological-features-of-quasi-moyamoya-disease-among-european-caucasians-including-surgical-treatment-and-outcome
#15
Güliz Acker, Susanne Goerdes, Peter Schmiedek, Marcus Czabanka, Peter Vajkoczy
BACKGROUND: Moyamoya disease (MMD) associated with a potentially underlying disease, such as genetic disorders or other coexisting hematological pathologies, is called quasi-MMD. This very rare disease has been characterized mainly in Asian countries, so far. As MMD reveals several significant ethnic differences, the question is raised whether characteristics of quasi-MMD would also vary among different ethnic backgrounds. Here, we report a series of 61 patients with quasi-MMD and highlight the specific clinical features of this rare disease among European Caucasians...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27578255/prognostic-significance-of-estimated-glomerular-filtration-rate-and-cystatin-c-in-patients-with-acute-intracerebral-hemorrhage
#16
Shoujiang You, Luyao Shi, Chongke Zhong, Jiaping Xu, Qiao Han, Xia Zhang, Huihui Liu, Yanlin Zhang, Jijun Shi, Zhichao Huang, Yongjun Cao, Chunfeng Liu
BACKGROUND: The effects of the estimated glomerular filtration rate (eGFR) and cystatin C on clinical outcomes on intracerebral hemorrhage (ICH) remain unclear. We investigated the associations of eGFR and cystatin C with 3-month functional outcome and all-cause mortality in acute ICH patients. METHODS: A total of 365 patients with acute ICH were enrolled. Serum creatinine and cystatin C levels were measured within 24 h of admission. Outcomes at 3-month were evaluated by interviews with patients or their family members...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27576326/cerebellar-infarction-and-factors-associated-with-delayed-presentation-and-misdiagnosis
#17
Zeljka Calic, Cecilia Cappelen-Smith, Craig S Anderson, Wei Xuan, Dennis J Cordato
BACKGROUND AND PURPOSE: The diagnosis of cerebellar infarction (CBI) is often challenging due to non-specific or subtle presenting symptoms and signs. We aimed to determine whether a common syndromic cluster of symptoms, signs or vascular risk factors were associated with delayed presentation or misdiagnosis to an Emergency Department (ED). The degree of misdiagnosis between ED and neurology physicians and the influence of delayed presentation or misdiagnosis on outcome were also investigated...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27536779/adverse-events-following-international-normalized-ratio-reversal-in-intracerebral-hemorrhage
#18
Mona Laible, Ekkehart Jenetzky, Christopher Beynon, Oliver Josef Müller, Peter Sander, Svenja Schüler, Jan Purrucker, Markus Möhlenbruch, Thorsten Steiner, Roland Veltkamp, Peter Arthur Ringleb, Timolaos Rizos
BACKGROUND: Prothrombin complex concentrates (PCCs) are frequently used to reverse the effect of vitamin K antagonists (VKAs) in patients with non-traumatic intracerebral hemorrhage (ICH). However, information on the rate of thromboembolic events (TEs) and allergic events after PCC therapy in VKA-ICH patients is limited. METHODS: Consecutive VKA-ICH patients treated with PCC at our institution between December 2004 and June 2014 were included into this retrospective observational study...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27505248/nonfocal-symptoms-in-patients-with-transient-ischemic-attack-or-ischemic-stroke-occurrence-clinical-determinants-and-association-with-cardiac-history
#19
Gerben J J Plas, Heleen A Booij, Paul J A M Brouwers, Marjolein Brusse-Keizer, Peter J Koudstaal, Diederik W J Dippel, Heleen M den Hertog
BACKGROUND: Transient ischemic attacks (TIAs) accompanied by nonfocal symptoms are associated with a higher risk of cardiovascular events, in particular cardiac events. Reported frequencies of TIAs accompanied by nonfocal symptoms range from 18 to 53%. We assessed the occurrence of nonfocal symptoms in patients with TIA or minor ischemic stroke in a neurological outpatient clinic in terms of clinical determinants, cardiac history, and atrial fibrillation (AF). METHODS: We included 1,265 consecutive patients with TIA or minor stroke who visited the outpatient clinic...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/27505159/risk-factors-for-stroke-in-people-with-end-stage-kidney-disease-a-cohort-study
#20
Philip Masson, Sradha Kotwal, Patrick J Kelly, Jonathan C Craig, Richard I Lindley, Martin Gallagher, Alan Cass, Angela C Webster
BACKGROUND: It is unclear how traditional cardiovascular risk factors and different treatment modalities for end-stage kidney disease (ESKD) affect stroke risk in people with ESKD. We aimed to identify the risk factors for stroke (ischemic and hemorrhagic) in people with ESKD. METHODS: We conducted a retrospective cohort study using data linkage between the Australian and New Zealand Dialysis and Transplant Registry, clinical and administrative datasets. Using Cox proportional hazards models, we estimated the magnitudes of risk of hospitalization with different subtypes of strokes associated with traditional cardiovascular risk factors and ESKD treatment modalities (hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation)...
2016: Cerebrovascular Diseases
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