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Cancer Causes & Control: CCC

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https://www.readbyqxmd.com/read/28238063/functional-germline-variants-in-driver-genes-of-breast-cancer
#1
Stella Göhler, Miguel Inacio Da Silva Filho, Robert Johansson, Kerstin Enquist-Olsson, Roger Henriksson, Kari Hemminki, Per Lenner, Asta Försti
PURPOSE: Germline mutations in tumour suppressor genes cause various cancers. These genes are also somatically mutated in sporadic tumours. We hypothesized that there may also be cancer-related germline variants in the genes commonly mutated in sporadic breast tumours. METHODS: After excluding the well-characterized breast cancer (BC) genes, we screened 15 novel genes consistently classified as BC driver genes in next-generation sequencing approaches for single nucleotide polymorphisms (SNPs)...
February 25, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28233113/trends-in-hormone-use-and-ovarian-cancer-incidence-in-us-white-and-australian-women-implications-for-the-future
#2
Penelope M Webb, Adèle C Green, Susan J Jordan
PURPOSE: To compare trends in ovarian cancer incidence in the USA and Australia in relation to changes in oral contraceptive pill (OCP) and menopausal hormone therapy (MHT) use. METHODS: US cancer incidence data (1973-2013) were accessed via SEER*Stat; Australian data (1982-2012) were accessed from the Australian Institute of Health and Welfare Cancer Incidence and Mortality books. Age-period-cohort models were constructed to assess trends in ovarian cancer incidence by birth cohort and year of diagnosis...
February 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28229344/variation-in-risk-and-outcomes-of-epstein-barr-virus-associated-breast-cancer-by-epidemiologic-characteristics-and-virus-detection-strategies-an-exploratory-study
#3
Sally L Glaser, Alison J Canchola, Theresa H M Keegan, Christina A Clarke, Teri A Longacre, Margaret L Gulley
PURPOSE: A relationship of Epstein-Barr virus (EBV) and breast cancer etiology and outcome may have clinical utility and potential to enhance understanding of tumor biology. Research to date has yielded variable results, likely reflecting differing virus detection assays and unaddressed epidemiologic heterogeneity across studies. METHODS: Applying our novel, five-target assay detection strategy in an exploratory study, we examined demographic, clinical, and tumor characteristics, and overall survival, associated with EBV positivity in breast adenocarcinomas from 59 non-Hispanic white and 68 Hispanic women sampled by age (<50, 50+) and stage (localized, regional/remote) and examined associations based on single assay targets...
February 22, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28224412/antihypertensive-medication-use-and-risk-of-renal-cell-carcinoma
#4
Joanne S Colt, Jonathan N Hofmann, Kendra Schwartz, Wong-Ho Chow, Barry I Graubard, Faith Davis, Julie Ruterbusch, Sonja Berndt, Mark P Purdue
PURPOSE: Use of antihypertensive medications has been associated with renal cell carcinoma (RCC), but it is unclear whether specific types of medications increase RCC risk independent of the effect of hypertension, or whether the association varies by histologic subtype. To address this question, we analyzed data from a U.S. population-based case-control study of RCC. METHODS: We collected information on participants' use of drugs to treat hypertension, heart problems, weight control, and swelling...
February 21, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28224411/personalized-medicine-for-prevention-can-risk-stratified-screening-decrease-colorectal-cancer-mortality-at-an-acceptable-cost
#5
Sujha Subramanian, Georgiy Bobashev, Robert J Morris, Sonja Hoover
PURPOSE: Tailored health care interventions are expected to transform clinical practice. The objective of this study was to develop an innovative model to assess the effectiveness, cost, and harms of risk stratified colorectal cancer screening. METHODS: We updated a previously validated microsimulation model consisting of three interlinked components: risk assessment, natural history, and screening/treatment modules. We used data from representative national surveys and the literature to create a synthetic population that mimics the family history and genetic profile of the US population...
February 21, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28220328/the-provision-of-dietary-and-physical-activity-advice-for-men-diagnosed-with-prostate-cancer-a-qualitative-study-of-the-experiences-and-views-of-health-care-professionals-patients-and-partners
#6
Eileen Sutton, Lucy E Hackshaw-McGeagh, Jonathan Aning, Amit Bahl, Anthony Koupparis, Raj Persad, Richard M Martin, J Athene Lane
PURPOSE: To explore the views and experiences of health care professionals (HCPs), men diagnosed with localised prostate cancer and their partners about the provision of advice on diet and physical activity after diagnosis and treatment for localised prostate cancer. METHODS: Semi-structured in-depth interviews with ten HCPs (Consultant Urological Surgeons, Uro-Oncology Clinical Nurse Specialists and Allied Health Professionals: see Table 1) and sixteen men diagnosed with localised prostate cancer and seven of their partners...
February 20, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28205047/pre-diagnosis-insulin-like-growth-factor-i-and-risk-of-epithelial-invasive-ovarian-cancer-by-histological-subtypes-a-collaborative-re-analysis-from-the-ovarian-cancer-cohort-consortium
#7
Jennifer Ose, Helena Schock, Elizabeth M Poole, Matti Lehtinen, Kala Visvanathan, Kathy Helzlsouer, Julie E Buring, I-Min Lee, Anne Tjønneland, Marie-Christine Boutron-Ruault, Antonia Trichopoulou, Amalia Mattiello, N Charlotte Onland-Moret, Elisabete Weiderpass, María-José Sánchez, Annika Idahl, Ruth C Travis, Sabina Rinaldi, Melissa A Merritt, Nicolas Wentzensen, Shelley S Tworoger, Rudolf Kaaks, Renée T Fortner
PURPOSE: Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. METHODS: We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC...
February 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28194593/synchronous-endometrial-and-ovarian-carcinomas-predictors-of-risk-and-associations-with-survival-and-tumor-expression-profiles
#8
Linda E Kelemen, Peter F Rambau, Jennifer M Koziak, Helen Steed, Martin Köbel
PURPOSE: Synchronous endometrial and ovarian tumors (SEOs) are diagnosed in 10% of ovarian cancer patients. We examined predictors of SEOs, evaluated associations of SEOs with survival and characterized ovarian tumor profiles using immunohistochemistry. METHODS: We included patients with endometrioid (n = 180) and clear cell (n = 165) ovarian carcinoma identified from the Alberta Cancer Registry between 1979 and 2010 for whom we abstracted medical records and constructed tumor tissue microarrays (TMAs)...
February 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28155006/adherence-to-the-mediterranean-diet-and-nasopharyngeal-cancer-risk-in-italy
#9
Federica Turati, Francesca Bravi, Jerry Polesel, Cristina Bosetti, Eva Negri, Werner Garavello, Martina Taborelli, Diego Serraino, Massimo Libra, Maurizio Montella, Adriano Decarli, Monica Ferraroni, Carlo La Vecchia
PURPOSE: Few studies investigated the role of diet on nasopharyngeal cancer (NPC) risk in non-endemic areas. The aim of this study was to assess the association between adherence to the traditional Mediterranean diet and NPC risk in a southern European low-risk population. METHODS: We conducted a hospital-based case-control study in Italy, including 198 histologically confirmed NPC cases and 594 matched controls. Dietary habits were collected by means of a validated food-frequency questionnaire, including 83 foods, food groups, or beverages...
February 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28130633/recent-declines-in-cancer-incidence-related-to-the-great-recession
#10
Scarlett Lin Gomez, Alison J Canchola, David O Nelson, Theresa H M Keegan, Christina A Clarke, Iona Cheng, Salma Shariff-Marco, Mindy DeRouen, Ralph Catalano, William A Satariano, Kathleen Davidson-Allen, Sally L Glaser
PURPOSE: In recent years, cancer case counts in the U.S. underwent a large, rapid decline-an unexpected change given population growth for older persons at highest cancer risk. As these declines coincided with the Great Recession, we examined whether they were related to economic conditions. METHODS: Using California Cancer Registry data from California's 30 most populous counties, we analyzed trends in cancer incidence during pre-recession (1996-2007) and recession/recovery (2008-2012) periods for all cancers combined and the ten most common sites...
January 27, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28102526/hormonal-and-reproductive-factors-and-the-risk-of-ovarian-cancer
#11
Anita Koushik, Anne Grundy, Michal Abrahamowicz, Jocelyne Arseneau, Lucy Gilbert, Walter H Gotlieb, Julie Lacaille, Anne-Marie Mes-Masson, Marie-Élise Parent, Diane M Provencher, Lesley Richardson, Jack Siemiatycki
PURPOSE: Hormone-related factors have been associated with ovarian cancer, the strongest being parity and oral contraceptive use. Given reductions in birth rates and increases in oral contraceptive use over time, associations in more recent birth cohorts may differ. Furthermore, consideration of ovarian cancer heterogeneity (i.e., Type I/II invasive cancers) may contribute to a better understanding of etiology. We examined hormone-related factors in relation to ovarian cancer risk overall, for Type I and Type II cancers, as well as borderline tumors...
January 19, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28097471/experiences-and-perceptions-regarding-clinical-breast-exam-screening-by-trained-laywomen-in-malawi
#12
Racquel E Kohler, Anna R Miller, Lily Gutnik, Clara N Lee, Satish Gopal
PURPOSE: Despite the increasing burden, breast cancer control in sub-Saharan Africa is insufficient. Late diagnosis and lack of early detection and screening services contribute to high mortality. Clinical breast exam (CBE) screening can be valuable in low-income countries, including use of community health workers and non-health professionals to conduct exams. We assessed experiences of women who underwent CBE screening by trained laywomen in Lilongwe, Malawi, as part of a pilot program...
January 17, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28083800/assessing-disparities-in-colorectal-cancer-mortality-by-socioeconomic-status-using-new-tools-health-disparities-calculator-and-socioeconomic-quintiles
#13
Nancy Breen, Denise Riedel Lewis, James Todd Gibson, Mandi Yu, Sam Harper
PURPOSE: Colorectal cancer mortality rates dropped by half in the past three decades, but these gains were accompanied by striking differences in colorectal cancer mortality by socioeconomic status (SES). Our research objective is to examine disparities in colorectal cancer mortality by SES, using a scientifically rigorous and reproducible approach with publicly available online tools, HD*Calc and NCI SES Quintiles. METHODS: All reported colorectal cancer deaths in the United States from 1980 to 2010 were categorized into NCI SES quintiles and assessed at the county level...
January 12, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28050675/predictors-of-pretreatment-ca125-at-ovarian-cancer-diagnosis-a-pooled-analysis-in-the-ovarian-cancer-association-consortium
#14
Ana Babic, Daniel W Cramer, Linda E Kelemen, Martin Köbel, Helen Steed, Penelope M Webb, Sharon E Johnatty, Anna deFazio, Diether Lambrechts, Marc T Goodman, Florian Heitz, Keitaro Matsuo, Satoyo Hosono, Beth Y Karlan, Allan Jensen, Susanne K Kjær, Ellen L Goode, Tanja Pejovic, Melissa Moffitt, Estrid Høgdall, Claus Høgdall, Iain McNeish, Kathryn L Terry
PURPOSE: Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the diagnosis of ovarian cancer patients, to monitor response to treatment and detect cancer recurrence. Besides tumor characteristics, CA125 levels are also influenced by several epidemiologic factors, such as age, parity, and oral contraceptive use. Identifying factors that influence CA125 levels in ovarian cancer patients could aid in the interpretation of CA125 values for individuals...
January 3, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28025765/incidence-of-malignant-mesothelioma-in-germany-2009-2013
#15
Martin Lehnert, Klaus Kraywinkel, Evelyn Heinze, Thorsten Wiethege, Georg Johnen, Julia Fiebig, Thomas Brüning, Dirk Taeger
PURPOSE: The malignant mesothelioma is a rare malignancy and mainly caused by occupational exposure to asbestos. German cancer registries are providing a national database to investigate temporal and regional patterns of mesothelioma incidence. These may be of interest for healthcare planning and for surveillance programs aiming at the formerly exposed workforce. METHODS: We analyzed population-based incidence data of malignant mesothelioma by site, type, sex, age, as well as district and state of patient's residence...
December 27, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28025764/a-prospective-study-of-reproductive-factors-and-exogenous-hormone-use-in-relation-to-ovarian-cancer-risk-among-black-women
#16
Traci N Bethea, Julie R Palmer, Lucile L Adams-Campbell, Lynn Rosenberg
PURPOSE: Extensive data in White women have linked oral contraceptive use, tubal ligation, and parity to reduced risk of ovarian cancer; results on postmenopausal female hormone use are mixed. Few studies, all of which are case-control studies, have been undertaken among Black women. The aim of the present study was to prospectively assess associations of reproductive factors and exogenous hormones with ovarian cancer among Black women. METHODS: During follow-up from 1995 to 2013 in the Black Women's Health Study, a prospective cohort study, 115 incident cases of ovarian cancer were identified...
December 27, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28025763/helicobacter-pylori-infection-is-an-independent-risk-factor-for-colonic-adenomatous-neoplasms
#17
Ji Hyung Nam, Chang Won Hong, Byung Chang Kim, Aesun Shin, Kum Hei Ryu, Bum Joon Park, Bun Kim, Dae Kyung Sohn, Kyung Su Han, Jeongseon Kim, Chan Wha Lee
PURPOSE: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase. METHODS: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs...
December 27, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28213874/disease-burden-of-human-papillomavirus-infection-in-the-netherlands-1989-2014-the-gap-between-females-and-males-is-diminishing
#18
Scott A McDonald, Venetia Qendri, Johannes Berkhof, Hester E de Melker, Johannes A Bogaards
PURPOSE: Besides cervical cancer, HPV infection is linked to a multitude of diseases in both males and females, suggesting that vaccination programmes should be re-evaluated, with a judicious assessment made of the disease burden stratified by sex, age, and genotype. Projections of burden into the near future are also needed to provide a benchmark for evaluating the impact of vaccination programmes, and to assess the need for scaling-up preventive measures. METHODS: Using the disability-adjusted life-years (DALY) measure, we estimated the total HPV-associated disease burden in the Netherlands...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28210884/energy-balance-and-obesity-what-are-the-main-drivers
#19
Isabelle Romieu, Laure Dossus, Simón Barquera, Hervé M Blottière, Paul W Franks, Marc Gunter, Nahla Hwalla, Stephen D Hursting, Michael Leitzmann, Barrie Margetts, Chizuru Nishida, Nancy Potischman, Jacob Seidell, Magdalena Stepien, Youfa Wang, Klaas Westerterp, Pattanee Winichagoon, Martin Wiseman, Walter C Willett
PURPOSE: The aim of this paper is to review the evidence of the association between energy balance and obesity. METHODS: In December 2015, the International Agency for Research on Cancer (IARC), Lyon, France convened a Working Group of international experts to review the evidence regarding energy balance and obesity, with a focus on Low and Middle Income Countries (LMIC). RESULTS: The global epidemic of obesity and the double burden, in LMICs, of malnutrition (coexistence of undernutrition and overnutrition) are both related to poor quality diet and unbalanced energy intake...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28210883/can-demographic-clinical-and-treatment-related-factors-available-at-hormonal-therapy-initiation-predict-non-persistence-in-women-with-stage-i-iii-breast-cancer
#20
Caitriona Cahir, Thomas I Barron, Linda Sharp, Kathleen Bennett
PURPOSE: To investigate whether demographic, clinical and treatment-related risk factors known at treatment initiation can be used to reliably predict future hormonal therapy non-persistence in women with breast cancer, and to inform intervention development. METHODS: Women with stage I-III breast cancer diagnosed 2000-2012 and prescribed hormonal therapy were identified from the National Cancer Registry Ireland (NCRI) and linked to pharmacy claims data from Ireland's Primary Care Reimbursement Services (PCRS)...
March 2017: Cancer Causes & Control: CCC
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