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Osteoporosis International

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https://www.readbyqxmd.com/read/28324132/erratum-to-cost-effectiveness-analysis-of-once-yearly-injection-of-zoledronic-acid-for-the-treatment-of-osteoporosis-in-japan
#1
K Moriwaki, M Mouri, H Hagino
No abstract text is available yet for this article.
March 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28324131/case-report-fast-reversal-of-severe-osteoporosis-after-correction-of-excessive-levothyroxine-treatment-and-long-term-follow-up
#2
C M Laine, K Landin-Wilhelmsen
This case report describes a 38-year-old woman, who presented with bilateral femoral stress fractures and osteoporosis after years of excessive levothyroxine treatment. Her bone health was restored rapidly and long-lasting with the reduction of levothyroxine dosage. No bone-active treatment was warranted. INTRODUCTION: Hyperthyroidism is a known risk factor for osteoporosis and fractures. Recent studies on patients with serum thyrotropin-suppressive therapy have not, however, indicated adverse effects on bone during long-term follow-up...
March 21, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28321507/the-relationship-between-cumulative-lifetime-ultraviolet-radiation-exposure-bone-mineral-density-falls-risk-and-fractures-in-older-adults
#3
M J W Thompson, D A Aitken, P Otahal, J Cicolini, T M Winzenberg, G Jones
Data linking cumulative lifetime vitamin D status with skeletal outcomes are lacking. We show that increasing cumulative sun exposure was associated with higher bone mineral density in younger males and protective against fractures in females independent of current vitamin D. This supports the concept that cumulative sun exposure is an important contributor to skeletal health. INTRODUCTION: While low 25-hydroxyvitamin D levels are associated with increased fracture risk, this reflects only recent sun exposure...
March 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28321506/standardizing-25-hydroxyvitamin-d-data-from-the-hunmen-cohort
#4
E Jakab, E Kalina, Z Petho, Z Pap, A Balogh, W B Grant, H P Bhattoa
Standardization of 25-hydroxyvitamin D (25OHD) values is still a challenge. We propose standardization by correction of the measured 25OHD values using the linear regression bias from the National Institute of Standards and Technology (NIST) 'total' target values reported by Vitamin D External Quality Assessment Scheme (DEQAS). Our approach could perhaps be a practical solution to the anomaly surrounding non-standardized 25OHD values. INTRODUCTION: Standardization of 25OHD values is still a challenge...
March 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28321505/cost-effective-measures-to-standardize-serum-25-oh-d-values-from-completed-studies
#5
EDITORIAL
C T Sempos, R A Durazo-Arvizu, G D Carter
No abstract text is available yet for this article.
March 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28315954/trends-in-osteoporosis-and-low-bone-mass-in-older-us-adults-2005-2006-through-2013-2014
#6
A C Looker, N Sarafrazi Isfahani, B Fan, J A Shepherd
This study examined trends in osteoporosis and low bone mass in older US adults between 2005 and 2014 using bone mineral density (BMD) data from the National Health and Nutrition Examination Survey (NHANES). Osteoporosis and low bone mass appear to have increased at the femur neck but not at the lumbar spine during this period. INTRODUCTION: Recent preliminary data from Medicare suggest that the decline in hip fracture incidence among older US adults may have plateaued in 2013-2014, but comparable data on BMD trends for this time period are currently lacking...
March 18, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28314898/economic-burden-of-osteoporosis-related-hip-fracture-in-asia-a-systematic-review
#7
REVIEW
N-A Mohd-Tahir, S-C Li
This review analyzes the economic costs of HF in Asia. The availability and quality of studies on the burden of osteoporosis in Asia are very scarce. There is a need to encourage more quality cost of osteoporosis studies based on standardized methods to convince healthcare authorities in implementing appropriate strategies. INTRODUCTION: Osteoporosis fractures, especially hip fractures, impose large economic costs to governments and societies. This review aimed to systematically analyze available evidence on healthcare costs associated with osteoporosis-related hip fractures (HF) in Asia...
March 17, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28314897/transient-osteoporosis-of-the-hip-review-of-the-literature
#8
REVIEW
K Asadipooya, L Graves, L W Greene
Transient osteoporosis of the hip (TOH) is a temporary clinical condition of unknown etiology which usually resolves with conservative therapy though may be complicated by fracture or progression to avascular necrosis (AVN). TOH may be slightly more prevalent in men but when it occurs in women, it is most often seen in the latter part of pregnancy. Though fracture is a rare complication of TOH when it occurs, it is most often associated with TOH occurring in pregnancy. Magnetic resonance imaging (MRI) is the best method to diagnosis TOH...
March 17, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28303396/the-incidence-of-hip-fracture-in-shiraz-iran-a-promising-rate-comparing-to-previous-studies
#9
N Maharlouei, S Atefi, H Namazi, S Kazemifar, M Soveid, H R Shahraki, Z Farahmand, M Khodayari, P Arab, F Forouzan, N Allamehzadeh, S Fazilat, S Khademolhosseini, F Nafari, K B Lankarani
We evaluate the incidence of hip fracture in 50 years old or above in southwest of Iran. Age-adjusted incidence rates of hip fracture, standardized to the 2000 US white population, were 79.55 per 10(5) in total and 66.51 and 92.37 per 10(5) in male and female, respectively. INTRODUCTION: Osteoporosis-related hip fracture is associated with considerable morbidity, mortality, and costs in older people. The aim of this study was to evaluate the incidence rate of hip fracture in the capital of Fars Province, southern Iran...
March 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28299378/factors-associated-with-acute-phase-response-of-bisphosphonate-na%C3%A3-ve-or-pretreated-women-with-osteoporosis-receiving-an-intravenous-first-dose-of-zoledronate-or-ibandronate
#10
A W Popp, R Senn, I Curkovic, C Senn, H Buffat, P F Popp, K Lippuner
A first intravenous dose of bisphosphonates may be associated with an acute-phase response (APR). In bisphosphonate-naïve women with postmenopausal osteoporosis, the characteristics and frequency of APR may differ by compound. Prior bisphosphonate exposure was predictive of APR risk and severity. INTRODUCTION: Intravenous (IV) administration of bisphosphonates (BP), such as zoledronate (ZOL) and ibandronate (IBN), may be associated with an APR. The characteristics of APR may differ by compound...
March 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28293690/bone-mineral-density-among-korean-females-aged-20-50%C3%A2-years-influence-of-age-at-menarche-the-korea-national-health-and-nutrition-examination-survey-2008-2011
#11
H K Chang, D-G Chang, J-P Myong, J-H Kim, S-J Lee, Y S Lee, H-N Lee, K H Lee, D C Park, C J Kim, S Y Hur, J S Park, T C Park
To evaluate a possible correlation between bone mineral density (BMD) and age at menarche, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey IV-V (KNHANES IV-V). Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20-50 years. INTRODUCTION: To investigate any correlation between bone mineral density (BMD) and age at menarche in Korean females using data from the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-V; 2008-2011)...
March 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28289780/multifaceted-interaction-of-bone-muscle-lifestyle-interventions-and-metabolic-and-cardiovascular-disease-role-of-osteocalcin
#12
REVIEW
I Levinger, T C Brennan-Speranza, A Zulli, L Parker, X Lin, J R Lewis, B B Yeap
Undercarboxylated osteocalcin (ucOC) may play a role in glucose homeostasis and cardiometabolic health. This review examines the epidemiological and interventional evidence associating osteocalcin (OC) and ucOC with metabolic risk and cardiovascular disease. The complexity in assessing such correlations, due to the observational nature of human studies, is discussed. Several studies have reported that higher levels of ucOC and OC are correlated with lower fat mass and HbA1c. In addition, improved measures of glycaemic control via pharmacological and non-pharmacological (e...
March 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28283689/recommendations-for-the-screening-of-adherence-to-oral-bisphosphonates-reply-to-comments-by-zhou-and-sheng
#13
LETTER
R Eastell, A Diez-Perez
No abstract text is available yet for this article.
March 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28283688/comments-on-diez-perez-et-al-recommendations-for-the-screening-of-adherence-to-oral-bisphosphonates
#14
LETTER
Y H Zhou, Z F Sheng
No abstract text is available yet for this article.
March 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28283687/impact-of-gain-of-function-mutations-in-the-low-density-lipoprotein-receptor-related-protein-5-lrp5-on-glucose-and-lipid-homeostasis
#15
D Foer, M Zhu, R L Cardone, C Simpson, R Sullivan, S Nemiroff, G Lee, R G Kibbey, K F Petersen, K L Insogna
LRP5 loss-of-function mutations have been shown to cause profound osteoporosis and have been associated with impaired insulin sensitivity and dysregulated lipid metabolism. We hypothesized that gain-of-function mutations in LRP5 would also affect these parameters. We therefore studied individuals with LRP5 gain-of-function mutations exhibiting high bone mass (HBM) phenotypes and found that while there was no detected change in insulin sensitivity, there was a significant reduction in serum LDL. INTRODUCTION: Wnt signaling through LRP5 represents a newly appreciated metabolic pathway, which potentially represents a target for drug discovery in type 2 diabetes and hyperlipidemia...
March 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28280857/conclusions-stand-firm-with-additional-data
#16
LETTER
C M Weaver, B Dawson-Hughes, J M Lappe, T C Wallace
No abstract text is available yet for this article.
March 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28275838/economic-evaluation-of-a-population-based-osteoporosis-intervention-for-outpatients-with-non-traumatic-non-hip-fractures-the-catch-a-break-1i-type-c-fls
#17
S R Majumdar, D A Lier, D A Hanley, A G Juby, L A Beaupre
Fracture liaison services (FLS) are advocated to improve osteoporosis treatment after fragility fracture, but there are few economic analyses of different models. A population-based 1i [=type C] FLS for non-hip fractures was implemented and it costs $44 per patient and it was very cost-effective ($9200 per QALY gained). Small operational changes would convert it from cost-effective to cost-saving. INTRODUCTION: After fragility fracture, <20% of patients receive osteoporosis treatment...
March 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28265719/health-state-utility-values-and-patient-reported-outcomes-before-and-after-vertebral-and-non-vertebral-fractures-in-an-osteoporosis-clinical-trial
#18
T Imai, S Tanaka, K Kawakami, T Miyazaki, H Hagino, M Shiraki
We assessed the health state utility value (HSUV) reductions associated with vertebral fractures using data collected in the Japanese Osteoporosis Intervention Trial-03 (JOINT-03). Our analysis revealed that assessment of HSUVs after morphometric vertebral fracture is important to capture the burden of vertebral fractures. INTRODUCTION: Evaluation of the HSUV after fracture is important to calculate the quality-adjusted life years (QALYs) of osteoporosis patients, which is essential information in the context of health economic evaluation...
March 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28265718/cost-effectiveness-analysis-of-once-yearly-injection-of-zoledronic-acid-for-the-treatment-of-osteoporosis-in-japan
#19
K Moriwaki, M Mouri, H Hagino
Model-based economic evaluation was performed to assess the cost-effectiveness of zoledronic acid. Although zoledronic acid was dominated by alendronate, the incremental quality-adjusted life year (QALY) was quite small in extent. Considering the advantage of once-yearly injection of zoledronic acid in persistence, zoledronic acid might be a cost-effective treatment option compared to once-weekly oral alendronate. INTRODUCTION: The purpose of this study was to estimate the cost-effectiveness of once-yearly injection of zoledronic acid for the treatment of osteoporosis in Japan...
March 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28265717/the-importance-of-physical-function-to-people-with-osteoporosis
#20
C Kerr, C Bottomley, S Shingler, L Giangregorio, H M de Freitas, C Patel, S Randall, D T Gold
There is increasing need to understand patient outcomes in osteoporosis. This article discusses that fracture in osteoporosis can lead to a cycle of impairment, driven by complex psychosocial factors, having a profound impact on physical function/activity which accumulates over time. More information is required on how treatments impact physical function. INTRODUCTION: There is increasing need to understand patient-centred outcomes in osteoporosis (OP) clinical research and management...
March 6, 2017: Osteoporosis International
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