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Osteoporosis International

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https://www.readbyqxmd.com/read/29344692/the-epidemiology-of-wrist-fractures-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#1
N C Wright, E R Hooker, C M Nielson, K E Ensrud, S L Harrison, E S Orwoll, E Barrett-Connor
There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance. INTRODUCTION: To calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study...
January 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330573/tocotrienol-supplementation-suppressed-bone-resorption-and-oxidative-stress-in-postmenopausal-osteopenic-women-a-12-week-randomized-double-blinded-placebo-controlled-trial
#2
C-L Shen, S Yang, M D Tomison, A W Romero, C K Felton, H Mo
Tocotrienols have shown bone-protective effect in animals. This study showed that a 12-week tocotrienol supplementation decreased concentrations of bone resorption biomarker and bone remodeling regulators via suppressing oxidative stress in postmenopausal osteopenic women. INTRODUCTION: Tocotrienols (TT) have been shown to benefit bone health in ovariectomized animals, a model of postmenopausal women. The purpose of this study was to evaluate the effect of 12-week TT supplementation on bone markers (serum bone-specific alkaline phosphatase (BALP), urine N-terminal telopeptide (NTX), serum soluble receptor activator of nuclear factor-kappaB ligand (sRANKL), and serum osteoprotegerin (OPG)), urine calcium, and an oxidative stress biomarker (8-hydroxy-2'-deoxyguanosine (8-OHdG)) in postmenopausal women with osteopenia...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29330572/effects-of-whole-body-vibration-on-muscle-strength-bone-mineral-content-and-density-and-balance-and-body-composition-of-children-and-adolescents-with-down-syndrome-a-systematic-review
#3
REVIEW
M B Saquetto, F F Pereira, R S Queiroz, C M da Silva, C S Conceição, M Gomes Neto
The aim of this study is to verify the effects of whole-body vibration (WBV) training on the muscle strength of children and adolescents with Down syndrome. We searched MEDLINE, Cochrane, SciELO, Lilacs and PUBMED databases and included manual searches to identify randomised controlled trials to investigate the effects of WBV on the structure and body function of children and adolescents with Down syndrome. Two reviewers independently selected the studies and performed statistical analysis. In total, five studies with 171 patients that compared WBV with exercise and/or control were included...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29327294/low-risk-for-hip-fracture-and-high-risk-for-hip-arthroplasty-due-to-osteoarthritis-among-swedish-farmers
#4
H Johansson, C Hongslo Vala, A Odén, M Lorentzon, E McCloskey, J A Kanis, N C Harvey, C Ohlsson, L Stefan Lohmander, J Kärrholm, D Mellström
We aimed to study the risk of hip fracture and risk of hip arthroplasty among farmers in Sweden. Our results indicate that farming, representing an occupation with high physical activity, in men is associated with a lower risk of hip fracture but an increased risk of hip arthroplasty. INTRODUCTION: The risks of hip fracture and hip arthroplasty are influenced by factors including socioeconomic status, education, urbanization, latitude of residence, and physical activity. Farming is an occupation encompassing rural living and high level of physical activity...
January 12, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29322223/is-the-timed-loaded-standing-test-a-valid-measure-of-back-muscle-endurance-in-people-with-vertebral-osteoporosis
#5
M Newman, R Newman, T Hughes, K Vadher, K L Barker
Timed loaded standing (TLS) is a suggested measure of back muscle endurance for people with vertebral osteoporosis. Surface electromyography revealed back muscles work harder and fatigue during TLS. The test end-point and total time were associated with back fatigue. The findings help demonstrate the concurrent validity of the TLS test. INTRODUCTION: The TLS test is suggested as a measure of back muscle endurance for patients with vertebral osteoporosis. However, to date, no study has demonstrated that TLS does measure back extensor or erector spinae (ES) muscle endurance...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#6
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29322221/feasibility-of-opportunistic-osteoporosis-screening-in-routine-contrast-enhanced-multi-detector-computed-tomography-mdct-using-texture-analysis
#7
M R K Mookiah, A Rohrmeier, M Dieckmeyer, K Mei, F K Kopp, P B Noel, J S Kirschke, T Baum, K Subburaj
This study investigated the feasibility of opportunistic osteoporosis screening in routine contrast-enhanced MDCT exams using texture analysis. The results showed an acceptable reproducibility of texture features, and these features could discriminate healthy/osteoporotic fracture cohort with an accuracy of 83%. INTRODUCTION: This aim of this study is to investigate the feasibility of opportunistic osteoporosis screening in routine contrast-enhanced MDCT exams using texture analysis. METHODS: We performed texture analysis at the spine in routine MDCT exams and investigated the effect of intravenous contrast medium (IVCM) (n = 7), slice thickness (n = 7), the long-term reproducibility (n = 9), and the ability to differentiate healthy/osteoporotic fracture cohort (n = 9 age and gender matched pairs)...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29306984/exercise-to-improve-functional-outcomes-in-persons-with-osteoporosis-a-systematic-review-and-meta-analysis
#8
REVIEW
A Varahra, I B Rodrigues, J C MacDermid, D Bryant, T Birmingham
Osteoporosis affects many aspects of daily life. The aim of this systematic review was to assess the effects of exercise interventions on functional outcomes in persons with osteoporosis, in comparison with controls. METHODS: Four databases were searched and yielded 1587 citations. Two reviewers independently determined study eligibility, rated risk of bias, appraised methodological quality of studies, and resolved discordance by consensus. RESULTS: A total of 28 studies examining 2113 participants met inclusion criteria; 25 studies were suitable for meta-analyses...
January 6, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29290026/trabecular-bone-quality-is-lower-in-adults-with-type-1-diabetes-and-is-negatively-associated-with-insulin-resistance
#9
V N Shah, R Sippl, P Joshee, L Pyle, W M Kohrt, I E Schauer, J K Snell-Bergeon
We evaluated trabecular bone score (TBS) and factors affecting TBS in adults with type 1 diabetes (T1D) compared to age-, sex-, and body mass index (BMI)-matched adults without diabetes. Adults with T1D had lower TBS compared to controls. Abdominal obesity and insulin resistance are associated with lower TBS. INTRODUCTION: We evaluated TBS, a non-invasive method to evaluate trabecular bone quality at the lumbar spine, in adults with T1D compared to age-, sex-, and BMI-matched adults without diabetes...
December 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29285628/diversity-of-activity-participation-determines-bone-mineral-content-in-the-lower-limbs-of-pre-pubertal-children-with-developmental-coordination-disorder
#10
S S M Fong, D Vackova, A W M Choi, Y T Y Cheng, T T T Yam, X Guo
This study examined the relationships between activity participation and bone mineralization in children with developmental coordination disorder. Limited participation in physical, recreational, social, and skill-based and self-improvement activities contributed to lower bone mineral content. For improved bone health, these children should participate in a variety of activities, not only physical activities. INTRODUCTION: Limited activity participation in children with developmental coordination disorder (DCD) may have a negative impact on bone mineral accrual...
December 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29285627/fracture-liaison-services-for-osteoporosis-in-the-asia-pacific-region-current-unmet-needs-and-systematic-literature-review
#11
REVIEW
Y -F Chang, C -F Huang, J -S Hwang, J -F Kuo, K -M Lin, H -C Huang, S Bagga, A Kumar, F -P Chen, C -H Wu
The analysis aimed to identify the treatment gaps in current fracture liaison services (FLS) and to provide recommendations for best practice establishment of future FLS across the Asia-Pacific region. The findings emphasize the unmet need for the implementation of new programs and provide recommendations for the refinement of existing ones. The study's objectives were to evaluate fracture liaison service (FLS) programs in the Asia-Pacific region and provide recommendations for establishment of future FLS programs...
December 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29282482/hip-fracture-trends-in-the-united-states-2002-to-2015
#12
E Michael Lewiecki, N C Wright, J R Curtis, E Siris, R F Gagel, K G Saag, A J Singer, P M Steven, R A Adler
An analysis of United States (US) Medicare claims data from 2002 to 2015 for women aged ≥ 65 years found that age-adjusted hip fracture rates for 2013, 2014, and 2015 were higher than projected, resulting in an estimated increase of more than 11,000 hip fractures. INTRODUCTION: Hip fractures are a major public health concern due to high morbidity, mortality, and healthcare expenses. Previous studies have reported a decrease in the annual incidence of hip fractures in the US beginning in 1995, coincident with the introduction of modern diagnostic tools and therapeutic agents for osteoporosis...
December 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29273827/stimulation-of-intestinal-calcium-absorption-by-orally-administrated-vitamin-d3-compounds-a-prospective-open-label-randomized-trial-in-osteoporosis
#13
K Uenishi, M Tokiwa, S Kato, M Shiraki
Intestinal fractional calcium absorption (FCA) was assessed before and after vitamin D3 treatment. Serum 1,25(OH)2D concentration was significantly increased by plain vitamin D3 and reduced by eldecalcitol. The 1α hydroxyl calcidiol and eldecalcitol treatments increased FCA, which may be induced through direct stimulation of vitamin D receptors in the intestine. INTRODUCTION: To assess the effects of vitamin D3 compounds on intestinal FCA and calcium-regulating hormones in post-menopausal osteoporosis, a randomized open-label prospective study was conducted...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29273826/frax-based-intervention-and-assessment-thresholds-in-seven-latin-american-countries
#14
P Clark, E Denova-Gutiérrez, C Zerbini, A Sanchez, O Messina, J J Jaller, C Campusano, C H Orces, G Riera, H Johansson, J A Kanis
Age-specific intervention and assessment thresholds were developed for seven Latin American countries. The intervention threshold ranged from 1.2% (Ecuador) to 27.5% (Argentina) at the age of 50 and 90 years, respectively. In the Latin American countries, FRAX offers a substantial advance for the detection of subjects at high fracture risk. INTRODUCTION: Intervention thresholds are proposed using the Fracture Risk Assessment (FRAX) tool. We recommended their use to calculate the ten-year probability of fragility fracture (FF) in both, men and women with or without the inclusion of bone mineral density (BMD)...
December 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29264626/acetylcholinesterase-inhibitors-and-the-risk-of-osteoporotic-fractures-nested-case-control-study
#15
I Tamimi, B Nicolau, H Eimar, S Arekunnath Madathil, A Kezouh, I Karp, F Tamimi
The objective of this study was to analyze the effect of acetylcholinesterase inhibitors (AChEIs) on the risk of osteoporotic fractures in Alzheimer patients. A nested case-control study was conducted on 1190 cases and 4760 controls. The use of AChEIs was found to decrease the risk of osteoporotic fractures in these patients. INTRODUCTION: The objective of this study is to estimate the extent to which the use of AChEIs is associated with a reduction in the risk of osteoporotic fractures...
December 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260292/vitamin-d-supplementation-and-bone-turnover-in-advanced-heart-failure-the-evita-trial
#16
A Zittermann, J B Ernst, S Prokop, U Fuchs, J Dreier, J Kuhn, H K Berthold, S Pilz, I Gouni-Berthold, J F Gummert
Low vitamin D status is common in patients with heart failure and may influence bone health. A daily vitamin D dose of 4000 IU (moderately high dose) for 3 years had however no effect on parameters of bone metabolism, even in patients with very low vitamin D status. INTRODUCTION: Low vitamin D status is common in patients with heart failure (HF) and has been related to disturbed bone turnover. The present study investigated the effect of a daily vitamin D3 dose of 4000 IU on bone turnover markers (BTMs) in patients with advanced HF and 25-hydroxyvitamin D (25OHD) concentrations < 75 nmol/L...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260291/a-dedicated-fracture-liaison-service-telephone-program-and-use-of-bone-turnover-markers-for-evaluating-1-year-persistence-with-oral-bisphosphonates
#17
P van den Berg, P M M van Haard, E van der Veer, P P Geusens, J P van den Bergh, D H Schweitzer
Telephone call intervention did not improve alendronate persistence in Fracture Liaison Service (FLS) patients in this study. A bone turnover marker cut-off point for alendronate persistence is proposed for individual FLS patients. INTRODUCTION: FLS aims to prevent subsequent fractures, which should include improving patients' persistence with prescribed oral bisphosphonates. We studied the influence of telephone calls and the predictive value of changes in bone turnover markers (BTMs) for evaluating persistence with alendronate...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260290/appropriateness-criteria-for-treatment-of-osteoporotic-vertebral-compression-fractures
#18
REVIEW
S Luthman, J Widén, F Borgström
The purpose of this study was to review and summarise the literature on appropriateness criteria for treatment of osteoporotic vertebral compression fractures (OVCF), with appropriateness defined as a treatment where the expected benefits outweigh the expected harms, confirmed by available evidence and expert opinion. A comprehensive search of peer-reviewed publications (PubMed, EMBASE) and grey literature was performed. To be included for analysis, documents had to be a review article (e.g. clinical guideline or meta-analysis), focus on OVCF and make a statement on treatment appropriateness...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260289/abaloparatide-a-novel-pth-receptor-agonist-increased-bone-mass-and-strength-in-ovariectomized-cynomolgus-monkeys-by-increasing-bone-formation-without-increasing-bone-resorption
#19
N Doyle, A Varela, S Haile, R Guldberg, P J Kostenuik, M S Ominsky, S Y Smith, G Hattersley
Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and trabecular bone mass. Abaloparatide increased bone strength and maintained or enhanced bone mass-strength relationships, indicating preserved or improved bone quality. INTRODUCTION: Abaloparatide is a selective PTH1R activator that is approved for the treatment of postmenopausal osteoporosis. The effects of 16 months of abaloparatide administration on bone formation, resorption, density, and strength were assessed in adult ovariectomized (OVX) cynomolgus monkeys (cynos)...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260288/remarkable-improvement-in-serum-25-hydroxyvitamin-levels-among-hip-fracture-patients-over-a-12-year-period-a-prospective-study-in-south-eastern-finland
#20
I Nurmi-Lüthje, R Tiihonen, E-L Paattiniemi, H Naboulsi, S Pigg, H Sarkkinen, J-P Kaukonen, A Toivanen, K Salmio, M Kataja, P Lüthje
Hypovitaminosis D is a problem among hip fracture patients. In a 1-year cohort study comprising 245 hip fracture patients (mean age of females 81 years and males 78 years) from south-eastern Finland, the mean 25-hydroxyvitamin D [S-25(OH)D] concentration was 73(SD 31) nmol/L. Vitamin D supplementation has been integrated into our current practice. INTRODUCTION: The objectives of this study are to verify vitamin D levels among hip fracture patients and to compare the results with a similar study conducted in the same two hospitals covering the same geographic area 12 years ago...
December 19, 2017: Osteoporosis International
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