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Osteoporosis International

V F Caparbo, C G S Saad, J C Moraes, A J de Brum-Fernandes, R M R Pereira
The present study investigates the osteoclastogenic capacity of peripheral blood mononuclear cells (PBMCs) in male patients with ankylosing spondylitis (AS). We demonstrated that monocytes from these patients display a lower capacity to generate osteoclasts compared to cells from healthy controls, and osteoclastogenesis was negatively correlated with disease duration. INTRODUCTION: Ankylosing spondylitis (AS) is a disease characterized by new bone growth that leads to syndesmophyte formation but AS patients frequently present with low bone mineral density/fractures...
July 13, 2018: Osteoporosis International
A J Søgaard, A H Ranhoff, H E Meyer, T K Omsland, W Nystad, G S Tell, K Holvik
The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount. INTRODUCTION: We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003)...
July 13, 2018: Osteoporosis International
A Ireland, S R Crozier, A E P Heazell, K A Ward, K M Godfrey, H M Inskip, C Cooper, N C Harvey
We compared bone outcomes in children with breech and cephalic presentation at delivery. Neonatal whole-body bone mineral content (BMC) and area were lower in children with breech presentation. At 4 years, no differences in whole-body or spine measures were found, but hip BMC and area were lower after breech presentation. INTRODUCTION: Breech presentation is associated with altered joint shape and hip dysplasias, but effects on bone mineral content (BMC), area (BA) and density (BMD) are unknown...
July 12, 2018: Osteoporosis International
B A Christiansen, S L Harrison, H A Fink, N E Lane
Bone loss following a fracture could increase the risk of future fractures. In this study, we found that elderly women who had an upper body fracture or multiple fractures lost more bone at the hip than those who did not fracture. This suggests a possible systemic bone loss response initiated by fracture. INTRODUCTION: A prior fracture is one of the strongest predictors of subsequent fracture risk, but the etiology of this phenomenon remains unclear. Systemic bone loss post-fracture could contribute to increased risk of subsequent fractures...
July 10, 2018: Osteoporosis International
R Vellucci, R Terenzi, J A Kanis, H G Kress, R D Mediati, J-Y Reginster, R Rizzoli, M L Brandi
Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic nociceptive and neuropathic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. Central sensitization seems to play a pivotal role in developing and maintaining chronicity of post-fracture pain in osteoporosis. Antiosteoporosis drugs are able to partially control pain, but additional analgesics are always necessary for pain due to bone fractures...
July 10, 2018: Osteoporosis International
I Bergström, J G Kerns, A E Törnqvist, C Perdikouri, N Mathavan, A Koskela, H B Henriksson, J Tuukkanen, G Andersson, H Isaksson, A E Goodship, S H Windahl
This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly.
July 9, 2018: Osteoporosis International
X B Mo, Y H Zhang, S F Lei
This study investigated the effect of the N6 -methyladenosine (m6 A)-associated SNPs on bone mineral density (BMD) and found plenty of m6 A-SNPs that were associated with BMD. This study increases our understanding on the regulation patterns of SNP and may provide new clues for further detection of functional mechanism underlying the associations between SNPs and osteoporosis. INTRODUCTION: m6 A plays critical roles in many fundamental biological processes and a variety of diseases. The m6 A-associated SNPs may be potential functional variants for BMD...
July 7, 2018: Osteoporosis International
M Nygård, M P Mosti, L Brose, G Flemmen, A K Stunes, A Sørskår-Venæs, J Heggelund, E Wang
Amphetamine use leads to impaired skeletal health and elevated risk of osteoporosis. In the current study, we document that maximal strength training (MST), as a part of clinical treatment, works as a countermeasure, improving muscle force generating capacity, body composition, and skeletal health at sites particularly prone to osteoporotic fractures. INTRODUCTION: Amphetamine users have attenuated musculoskeletal health. MST with heavy loads, few repetitions, and emphasis on maximal mobilization in the concentric phase may increase muscle force generating capacity and skeletal health...
July 5, 2018: Osteoporosis International
T Amorim, C Durães, J C Machado, G S Metsios, M Wyon, J Maia, A D Flouris, F Marques, L Nogueira, N Adubeiro, Y Koutedakis
The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β-catenin and ER pathways. INTRODUCTION: Some athletes (e.g. gymnasts, dancers, swimmers) are at increased risk for low bone mineral density (BMD) which, if untreated, can lead to osteoporosis. To investigate the association of genetic polymorphisms in the oestrogen receptor (ER) and the Wnt/β-catenin signalling pathways with low BMD in elite and pre-elite dancers (impact sport athletes)...
July 5, 2018: Osteoporosis International
Q-Y Wu, F-L Yuan, B Wang, X Li
No abstract text is available yet for this article.
July 5, 2018: Osteoporosis International
A Gilsenan, A Harding, N Kellier-Steele, D Harris, K Midkiff, E Andrews
The Forteo Patient Registry (FPR) aims to estimate the incidence of osteosarcoma in US patients treated with teriparatide. Enrollment began in 2009 and will continue through 2019, with linkage planned through 2024. To date, no incident cases of osteosarcoma have been identified among patients registered in the FPR. INTRODUCTION: The Forteo Patient Registry (FPR) was established in 2009 to estimate the incidence of osteosarcoma in US patients treated with teriparatide. The objective of this paper is to describe study methods, challenges encountered, and progress to date...
July 5, 2018: Osteoporosis International
R Winzenrieth, L Humbert, S Di Gregorio, E Bonel, M García, L Del Rio
Effects of osteoporosis drugs on proximal femur cortical and trabecular bone were studied using dual-energy x-ray absorptiometry (DXA)-based 3D modeling method. Changes observed in this head-to-head study were consistent with those obtained using computed tomography in the literature. INTRODUCTION: The aim of the present study was to assess the effects of osteoporosis drugs on cortical and trabecular bone at the proximal femur using DXA-based 3D modeling. METHODS: We retrospectively analyzed 155 patients stratified by treatments: naive of treatment (NAIVE), alendronate (AL), denosumab (DMAB), and teriparatide (TPTD)...
July 4, 2018: Osteoporosis International
S Galli, M Stocchero, M Andersson, J Karlsson, W He, T Lilin, A Wennerberg, R Jimbo
This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the paper have been modified accordingly.
July 3, 2018: Osteoporosis International
B-J Kim, M K Kwak, S H Ahn, J S Kim, S H Lee, J-M Koh
Despite ethnic differences in cortisol sensitivity, only one study in Caucasians has assessed trabecular bone score (TBS) in patients with subclinical hypercortisolism (SH). We showed that both subtle cortisol excess and reduced adrenal androgen may contribute to impaired bone quality in Asian women with SH. INTRODUCTION: One study in Caucasians has assessed trabecular bone score (TBS), an index of bone microstructure, in adrenal incidentaloma (AI) patients with subclinical hypercortisolism (SH)...
July 3, 2018: Osteoporosis International
A Shudo, H Kishimoto, K Takaoka, K Noguchi
Tooth extraction in patients receiving bisphosphonates is thought to be a risk factor for osteonecrosis of the jaw (ONJ); however, ONJ did not develop, even when tooth extraction was performed with continued oral bisphosphonate therapy. A drug holiday from bisphosphonates before tooth extraction may not be necessary. INTRODUCTION: It is controversial whether bisphosphonate withdrawal is necessary prior to invasive procedures such as tooth extraction in order to prevent bisphosphonate-related osteonecrosis of the jaw (BRONJ)...
July 2, 2018: Osteoporosis International
S A Bowden, B H Adler
No abstract text is available yet for this article.
July 2, 2018: Osteoporosis International
L T Ho-Pham, P M N Chau, A T Do, H C Nguyen, T V Nguyen
It is not clear why type 2 diabetes (T2D) has an increased risk of fracture despite higher areal bone mineral density. This study showed that compared with controls, T2D patients had higher trabecular bone density but lower cortical bone density, resulting in a lower bone strength. INTRODUCTION: To define the association between type 2 diabetes and bone architecture and measures of bone strength. METHODS: The study was part of the Vietnam Osteoporosis Study, in which 1115 women and 614 men aged ≥ 30 were randomly recruited from Ho Chi Minh City...
July 2, 2018: Osteoporosis International
L-C Desbiens, A Sidibé, R-V Ung, C Fortier, M Munger, Y-P Wang, S-K Bisson, K Marquis, M Agharazii, F Mac-Way
We performed a case-control study on 130 age- and sex-matched hemodialysis patients. In multivariate analysis, we observed that FGF23 levels were associated with fracture incidence and that soluble α-klotho levels were associated with the aortic-brachial arterial stiffness ratio. INTRODUCTION: New bone markers such as sclerostin, Dickkopf-related protein 1 (DKK1), fibroblast growth factor-23 (FGF23), and α-klotho have been identified as potential key players in bone and vascular abnormalities of chronic kidney disease...
June 29, 2018: Osteoporosis International
L L Rødbro, L S Bislev, T Sikjær, L Rejnmark
Increased levels of parathyroid hormone (PTH) may have adverse effects on bone health. In a cross-sectional design, we investigated this hypothesis among 102 postmenopausal vitamin D insufficient women. Elevated PTH was associated with altered bone geometry, decreased bone mineral density in the spine, and increased bone turnover. INTRODUCTION: In vitamin D insufficiency, elevated parathyroid hormone (PTH) levels may contribute to adverse effect on bone. We assessed effects of PTH responses to vitamin D insufficiency on bone metabolism, density, and geometry...
June 28, 2018: Osteoporosis International
L-C Liu, M-C Lu, S-Y Wang, H Livneh, N-S Lai, T-Y Tsai
This is the first study that has found that rehabilitation services (RS) intervention, following the onset of rheumatoid arthritis (RA), may significantly reduce the risk of osteoporosis in RA patients. Those patients who received more than five sessions of RS had the greatest benefit for the prevention of osteoporosis. INTRODUCTION: People with rheumatoid arthritis have increased risk of developing osteoporosis (OP). It remains unclear whether use of rehabilitation services can reduce the risk of developing OP...
June 27, 2018: Osteoporosis International
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