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Osteoporosis International

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https://www.readbyqxmd.com/read/28730547/sideways-fall-induced-impact-force-and-its-effect-on-hip-fracture-risk-a-review
#1
REVIEW
M Nasiri Sarvi, Y Luo
Osteoporotic hip fracture, mostly induced in falls among the elderly, is a major health burden over the world. The impact force applied to the hip is an important factor in determining the risk of hip fracture. However, biomechanical researches have yielded conflicting conclusions about whether the fall-induced impact force can be accurately predicted by the available models. It also has been debated whether or not the effect of impact force has been considered appropriately in hip fracture risk assessment tools...
July 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28725987/gene-mutation-spectrum-and-genotype-phenotype-correlation-in-a-cohort-of-chinese-osteogenesis-imperfecta-patients-revealed-by-targeted-next-generation-sequencing
#2
Y Liu, Asan, D Ma, F Lv, X Xu, J Wang, W Xia, Y Jiang, O Wang, X Xing, W Yu, J Wang, J Sun, L Song, Y Zhu, H Yang, J Wang, M Li
The achievement of more accurate diagnosis would greatly benefit the management of patients with osteogenesis imperfecta (OI). In this study, we present the largest OI sample in China as screened by next generation sequencing. In particular, we successfully identified 81 variants, which included 45 novel variants. We further did a genotype-phenotype analysis, which helps make a better understanding of OI. INTRODUCTION: This study aims to reveal the gene mutation spectrum and the genotype-phenotype relationship among Chinese OI patients by next generation sequencing (NGS)...
July 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28725986/patterns-of-alcohol-consumption-and-risk-of-falls-in-older-adults-a-prospective-cohort-study
#3
R Ortolá, E García-Esquinas, I Galán, P Guallar-Castillón, E López-García, J R Banegas, F Rodríguez-Artalejo
Falls are a major health problem in older adults, but their relationship with alcohol consumption in this population remains unclear. In a cohort with 2170 older adults followed up for 3.3 years, both moderate drinking and the Mediterranean drinking pattern were associated with a lower risk of falls and injurious falls. INTRODUCTION: This study aims to examine the association between certain patterns of alcohol consumption, including the Mediterranean drinking pattern (MDP), and the risk of falls in older adults...
July 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28725985/diversity-in-fall-characteristics-hampers-effective-prevention-the-precipitants-the-environment-the-fall-and-the-injury
#4
K M Sanders, K Lim, A L Stuart, A Macleod, D Scott, G C Nicholson, L Busija
Falls among the elderly are common and characteristics may differ between injurious and non-injurious falls. Among 887 older Australian women followed for 1.6 years, 32% fell annually. Only 8.5% resulted in fracture and/or hospital admission. The characteristics of those falls are indistinguishable from those not coming to medical attention. INTRODUCTION: The precipitants and environment of all falls occurring among a large cohort of older Caucasian women were categorised by injury status to determine if the characteristics differed between injurious and non-injurious falls...
July 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28714038/one-and-two-year-persistence-with-different-anti-osteoporosis-medications-a-retrospective-cohort-study
#5
C Reyes, C Tebe, D Martinez-Laguna, M S Ali, A Soria-Castro, C Carbonell, D Prieto-Alhambra
Adherence to anti-osteoporosis medications is poor. We carried out a cohort study using a real-world population database to estimate the persistence of anti-osteoporosis drugs. Unadjusted 2-year persistence ranged from 10.3 to 45.4%. Denosumab users had a 40% lower risk of discontinuation at 2 years compared to alendronate users. PURPOSE: The purpose of this study was to estimate real-world persistence amongst incident users of anti-osteoporosis medications. METHODS: This is a retrospective cohort using data from anonymised records and dispensation data ( www...
July 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28707090/fracture-risk-reduction-with-use-of-dipeptidyl-peptidase-4-inhibitors-is-there-immortal-time-bias
#6
LETTER
J H M Driessen, L M Knapen, P P M M Geusens, J P W van den Bergh
No abstract text is available yet for this article.
July 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28707089/fracture-risk-reduction-with-use-of-dipeptidyl-peptidase-4-inhibitors-response-to-driessen-et-al
#7
LETTER
K Kostev, S Dombrowski
No abstract text is available yet for this article.
July 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28702682/abdominal-obesity-and-risk-of-hip-fracture-a-meta-analysis-of-prospective-studies
#8
X Li, X Gong, W Jiang
We conducted a meta-analysis to qualitatively summarize the evidence of the association between abdominal obesity and hip fracture risk. The results indicated that abdominal obesity as measured by waist circumference and waist-hip ratio might be associated with an increased risk of hip fracture. INTRODUCTION: Epidemiological investigations evaluating the association of abdominal obesity with hip fracture risk have yielded conflicting results. Therefore, a meta-analysis was conducted to qualitatively summarize the evidence of the associations between waist circumference, waist-hip ratio, and hip circumference and the risk of hip fracture, respectively...
July 12, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28695242/spine-fracture-prevalence-in-a-nationally-representative-sample-of-us-women-and-men-aged-%C3%A2-40%C3%A2-years-results-from-the-national-health-and-nutrition-examination-survey-nhanes-2013-2014-supplementary-presentation
#9
F Cosman
Spine fracture prevalence is similar in men and women, increasing from <5% in those <60 to 11% in those 70-79 and 18% in those ≥80 years. Prevalence was higher with age, lower bone mineral density (BMD), and in those meeting criteria for spine imaging. Most subjects with spine fractures were unaware of them.
July 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28689307/long-term-follow-up-in-osteogenesis-imperfecta-type-vi
#10
P Trejo, T Palomo, K Montpetit, F Fassier, A Sato, F H Glorieux, F Rauch
This retrospective study on long-term outcomes in osteogenesis imperfecta type VI found that patients who received intravenous bisphosphonate treatment had an increase in lumbar spine areal bone mineral density, a higher final height z-score, and some reshaping of vertebral bodies. INTRODUCTION: Osteogenesis imperfecta (OI) type VI is an ultra-rare bone fragility disorder caused by recessive mutations in SERPINF1. Here, we describe long-term outcomes in OI type VI and compare the clinical phenotypes caused by different types of SERPINF1 mutations...
July 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28689306/targeted-spine-strengthening-exercise-and-posture-training-program-to-reduce-hyperkyphosis-in-older-adults-results-from-the-study-of-hyperkyphosis-exercise-and-function-sheaf-randomized-controlled-trial
#11
W B Katzman, E Vittinghoff, F Lin, A Schafer, R K Long, S Wong, A Gladin, B Fan, B Allaire, D M Kado, N E Lane
A 6-month randomized controlled trial of spine-strengthening exercise and posture training reduced both radiographic and clinical measures of kyphosis. Participants receiving the intervention improved self-image and satisfaction with their appearance. Results suggest that spine-strengthening exercise and postural training may be an effective treatment option for older adults with hyperkyphosis. INTRODUCTION: The purpose of the present study is to determine in a randomized controlled trial whether spine-strengthening exercises improve Cobb angle of kyphosis in community-dwelling older adults...
July 8, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28687861/are-more-trials-of-calcium-supplements-really-needed
#12
LETTER
M J Bolland, A Grey, I R Reid
No abstract text is available yet for this article.
July 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28687860/are-more-trials-of-calcium-supplements-really-needed-a-response-to-bolland-et-al
#13
LETTER
N C Harvey, C Cooper
No abstract text is available yet for this article.
July 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685283/short-term-effects-of-extracorporeal-shock-wave-therapy-on-bone-mineral-density-in-postmenopausal-osteoporotic-patients
#14
L Shi, F Gao, W Sun, B Wang, W Guo, L Cheng, Z Li, W Wang
It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporotic patients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration. INTRODUCTION: This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD). METHODS: A total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685282/bone-mineral-density-in-adults-with-down-syndrome
#15
A Carfì, R Liperoti, D Fusco, S Giovannini, V Brandi, D L Vetrano, E Meloni, D Mascia, E R Villani, E Manes Gravina, R Bernabei, G Onder
This study analyzed data of bone mineral density (BMD) from a large cohort of adults with Down syndrome (DS). BMD was found to decrease with age more rapidly in these subjects than in the general population, exposing adults with DS to an increased risk of osteoporosis and bone fracture. INTRODUCTION: Down syndrome (DS) in adulthood presents with a high prevalence of osteoporosis. However, in DS, bone mineral density (BMD) can be underestimated due to short stature. Furthermore, the rate of age-related decline in BMD and its association with gender in DS has been rarely evaluated or compared with the general population...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685281/osteoporosis-exercise-knowledge-and-education-in-medicine-and-nursing
#16
LETTER
V H Nguyen
No abstract text is available yet for this article.
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685280/osteoporosis-exercise-knowledge-and-education-in-medicine-and-nursing-response-to-comments-by-nguyen
#17
LETTER
L Giangregorio, R Clark, C McArthur, A Papaioannou, A M Cheung, J Laprade, L Lee, R Jain
No abstract text is available yet for this article.
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685279/marginal-structural-model-to-evaluate-the-association-between-cumulative-osteoporosis-medication-and-infection-using-claims-data
#18
F Xue, V Goli, P Petraro, T McMullan, J M Sprafka, E J Tchetgen Tchetgen
Due to the suboptimal persistence to osteoporosis (OP) treatment, factors triggering treatment discontinuation/switching may be causing time-varying confounding. BP treatment was associated with the risk of overall infection in opposite directions in the unweighted Cox model versus the weighted MSM. The discrepancy of effect estimates for overall infection in the MSM suggested there may be time-varying confounding. INTRODUCTION: Due to the suboptimal persistence to osteoporosis (OP) treatment, factors triggering treatment discontinuation/switching may be affected by prior treatment and confound the subsequent treatment effect, causing time-varying confounding...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28685278/does-regional-loss-of-bone-density-explain-low-trauma-distal-forearm-fractures-in-men-the-mr-f-study
#19
B C Hanusch, S P Tuck, R J Q McNally, J J Wu, M Prediger, J Walker, J Tang, I Piec, W D Fraser, H K Datta, R M Francis
The pathogenesis of low trauma wrist fractures in men is not fully understood. This study found that these men have lower bone mineral density at the forearm itself, as well as the hip and spine, and has shown that forearm bone mineral density is the best predictor of wrist fracture. INTRODUCTION: Men with distal forearm fractures have reduced bone density at the lumbar spine and hip sites, an increased risk of osteoporosis and a higher incidence of further fractures. The aim of this case-control study was to investigate whether or not there is a regional loss of bone mineral density (BMD) at the forearm between men with and without distal forearm fractures...
July 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28668994/validation-of-frax-and-the-impact-of-self-reported-falls-among-elderly-in-a-general-population-the-hunt-study-norway
#20
M Hoff, H E Meyer, S Skurtveit, A Langhammer, A J Søgaard, U Syversen, A Dhainaut, E Skovlund, B Abrahamsen, B Schei
Fracture Risk Assessment Tool (FRAX) without bone mineral density (BMD) for hip fracture prediction was validated in a Norwegian population 50-90 years. Fracture risk increased with higher FRAX score, and the observed number of hip fractures agreed well with the predicted number, except for the youngest and oldest men. Self-reported fall was an independent risk factor for fracture in women. INTRODUCTION: The primary aim was to validate FRAX without BMD for hip fracture prediction in a Norwegian population of men and women 50-90 years...
July 1, 2017: Osteoporosis International
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