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Osteoporosis International

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https://www.readbyqxmd.com/read/28815282/correction-of-vitamin-d-status-by-calcidiol-pharmacokinetic-profile-safety-and-biochemical-effects-on-bone-and-mineral-metabolism-of-daily-and-weekly-dosage-regimens
#1
S Minisola, L Cianferotti, P Biondi, C Cipriani, C Fossi, F Franceschelli, F Giusti, G Leoncini, J Pepe, H A Bischoff-Ferrari, M L Brandi
RATIONALE: Calcidiol can be employed to correct vitamin D deficiency. MAIN RESULTS: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism. SIGNIFICANCE: Calcidiol supplementation is effective and safe. INTRODUCTION: The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis...
August 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28812111/syndrome-of-inappropriate-anti-diuresis-induces-volume-dependent-hypercalciuria
#2
J Grellier, A Jaafar, A Martin, M El Alaoui, C Lebely, I Tack, M Vallet
Hyponatremia is associated with bone demineralization. We hypothesized that, during hyponatremia, calciuria and calcium balance depend on volemic status. We evaluated calciuria in patients with hyponatremia, secondary to SIAD or hypovolemia. Patients with SIAD exhibited a volemic expansion that was associated with hypercalciuria. Calciuria was proportional to markers of volemia. INTRODUCTION: Chronic mild hyponatremia has been associated with bone demineralization of unknown mechanisms...
August 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28808745/parathyroid-hormone-1-34-promotes-fracture-healing-in-ovariectomized-rats-with-type-2-diabetes-mellitus
#3
G Y Liu, G L Cao, F M Tian, H P Song, L L Yuan, L D Geng, Z Y Zheng, L Zhang
Ovariectomized (OVX) rats with type 2 diabetes mellitus (T2DM) with femur fracture received vehicle, insulin, or insulin plus parathyroid hormone (PTH) treatment for 2 and 3 weeks. Radiography, histomorphometry, histology, and immunohistochemistry in callus were evaluated. INTRODUCTION: Reports about effects of PTH plus insulin on callus formation of osteoporotic fracture with T2DM were limited. This study was designed to investigate the effects of the combination of PTH and insulin on fracture healing in OVX rats with T2DM...
August 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28795239/risk-of-low-energy-fracture-in-type-2-diabetes-patients-a-meta-analysis-of-observational-studies
#4
P Jia, L Bao, H Chen, J Yuan, W Liu, F Feng, J Li, H Tang
In this meta-analysis, evidence of an association between type 2 diabetes mellitus (T2DM) and low-energy fractures has been evaluated including 12 observational studies. The results suggested that T2DM patients had an enhanced risk of low-energy fractures. INTRODUCTION: Type 1 diabetes mellitus (T1DM) patients have been shown to be at enhanced risk of fracture injury, but less is known about low-energy fractures among patients with T2DM. METHODS: We performed a meta-analysis of 12 observational studies identified in Medline and EMBASE that included 938,742 participants, including 30,827 low-energy fracture cases...
August 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28795206/children-and-adolescents-with-cystic-fibrosis-display-moderate-bone-microarchitecture-abnormalities-data-from-high-resolution-peripheral-quantitative-computed-tomography
#5
C Braun, J Bacchetta, P Braillon, R Chapurlat, J Drai, P Reix
We investigated whether bone microstructure assessed by high-resolution peripheral quantitative tomography (HR-pQCT) could be altered in children and teenagers with cystic fibrosis (CF). In comparison to their healthy counterparts, bone microstructure was mildly affected at the tibial level only. INTRODUCTION: Cystic fibrosis-related bone disease (CFBD) may alter bone health, ultimately predisposing patients to bone fractures. Our aim was to assess bone microstructure using high-resolution peripheral quantitative tomography (HR-pQCT) in a cohort of children and teenagers with CF in comparison to age-, puberty-, and gender-matched healthy volunteers (HVs)...
August 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28791436/musculoskeletal-health-in-newly-diagnosed-children-with-crohn-s-disease
#6
L M Ward, J Ma, F Rauch, E I Benchimol, J Hay, M B Leonard, M A Matzinger, N Shenouda, B Lentle, H Cosgrove, M Scharke, V N Konji, D R Mack
We evaluated the impact of Crohn's disease on muscle and bone strength, mass, density, and geometry in children with newly diagnosed CD and found profound muscle and bone deficits; nevertheless, the prevalence of vertebral fractures at this time point was low. INTRODUCTION: Crohn's disease (CD) is an inflammatory condition of the gastrointestinal tract that can affect the musculoskeletal system. The objective of this study was to determine the prevalence of vertebral fractures and the impact of CD on muscle and bone mass, strength, density, and geometry in children with newly diagnosed CD...
August 8, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28785980/comparison-of-spinal-alignment-muscular-strength-and-quality-of-life-between-women-with-postmenopausal-osteoporosis-and-healthy-volunteers
#7
N Miyakoshi, D Kudo, M Hongo, Y Kasukawa, Y Ishikawa, Y Shimada
This study compared spinal alignment, muscular strength, and quality of life (QOL) between women with postmenopausal osteoporosis and healthy volunteers. The results indicated that lower QOL in osteoporosis patients may be associated with increased thoracic kyphosis, reduced lean muscle mass, and generalized muscle weakness. INTRODUCTION: Increased spinal kyphosis is common in patients with osteoporosis and negatively impacts quality of life (QOL). Muscular strength is also important for QOL in patients with osteoporosis...
August 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28785979/erratum-to-identification-and-management-of-patients-at-increased-risk-of-osteoporotic-fracture-outcomes-of-an-esceo-expert-consensus-meeting
#8
J A Kanis, C Cooper, R Rizzoli, B Abrahamsen, N M Al-Daghri, M L Brandi, J Cannata-Andia, B Cortet, H P Dimai, S Ferrari, P Hadji, N C Harvey, M Kraenzlin, A Kurth, E McCloskey, S Minisola, T Thomas, J-Y Reginster
No abstract text is available yet for this article.
August 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28782072/frax-vs-t-score-based-intervention-thresholds-for-osteoporosis
#9
H Johansson, F Azizieh, N Al Ali, T Alessa, N C Harvey, E McCloskey, J A Kanis
Many current guidelines for the assessment of osteoporosis, including those in Kuwait, initiate fracture risk assessment in men and women using BMD T-score thresholds. We compared the Kuwaiti guidelines with FRAX-based age-dependent intervention thresholds equivalent to that in women with a prior fragility fracture. FRAX-based intervention thresholds identified women at higher fracture probability than fixed T-score thresholds, particularly in the elderly. PURPOSE: A FRAX® model been recently calibrated for Kuwait, but guidance is needed on how to utilise fracture probabilities in the assessment and treatment of patients...
August 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28780727/interventions-for-humeral-shaft-fractures-mixed-treatment-comparisons-of-clinical-trials
#10
Y Zhao, J Wang, W Yao, Q Cai, Y Wang, W Yuan, S Gao
We designed a study to compare the efficacy of five main therapeutic options, including external fixation, open reduction and plate osteosynthesis (ORPO), minimally invasive plate osteosynthesis (MIPO), dynamic compression plate (DCP), and intramedullary nail (IMN) in treating humeral shaft fractures. Our results indicated that MIPO and IMN were recommended as the optimal treatments for clinical use. PURPOSE: Nowadays, five main therapeutic options are used in treating humeral shaft fractures: external fixation, open reduction and plate osteosynthesis (ORPO), minimally invasive plate osteosynthesis (MIPO), dynamic compression plate (DCP), and intramedullary nail (IMN)...
August 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28779302/skeletal-complications-of-rheumatoid-arthritis
#11
REVIEW
L Heinlen, M B Humphrey
Rheumatoid arthritis (RA) is associated with local and systemic inflammation that induces many changes in the skeletal health. Locally, periarticular bone loss and juxta-articular bone erosions may occur while joint ankylosis, generalized bone loss, osteoporosis, and fractures may develop secondary to inflammation. The aim of this narrative review is to summarize the clinical evidence for abnormal skeletal health in RA, the effects of disease modifying anti-rheumatic drugs (DMARDS) on bone health, and the effects of drugs for the prevention or treatment of osteoporosis in the RA population...
August 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28776184/impact-of-sign-guideline-thresholds-for-dxa-access-for-patients-referred-to-direct-access-dxa-implications-for-clinical-practice
#12
LETTER
C Wilson, P B Loughrey, B Cummings, C McNally, J R Lindsay
No abstract text is available yet for this article.
August 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28770273/atypical-femur-fractures-a-survey-of-current-practices-in-orthopedic-surgery
#13
P S Schneider, M Wall, J P Brown, A M Cheung, E J Harvey, S N Morin
The results of a self-administered online survey demonstrate that orthopedic surgeons' management practices for AFF are variable. These data will inform the development of clinical practice guidelines. INTRODUCTION: We aimed to determine current AFF treatment practices of orthopedic surgeons to inform clinical practice guideline development. METHODS: A self-administered online survey was developed and sequentially posted on the Orthopaedic Trauma Association (OTA) website from July to August 2015 and the Canadian Orthopaedic Association (COA) website from December 2015 to January 2016...
August 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28770272/effectiveness-of-anti-osteoporotic-drugs-to-prevent-secondary-fragility-fractures-systematic-review-and-meta-analysis
#14
REVIEW
T Saito, J M Sterbenz, S Malay, L Zhong, M P MacEachern, K C Chung
Patients with osteoporotic fractures have an increased risk for secondary fractures. However, a rigorous study that assesses the effectiveness of individual osteoporotic drugs in preventing subsequent fractures is lacking. The purpose of this review was to analyze the effectiveness of anti-osteoporotic drugs in preventing secondary fractures. We searched for randomized controlled trials that showed the incidence of secondary fractures while using anti-osteoporotic drugs (bisphosphonates, selective estrogen receptor modulators, parathyroid hormone (PTH), or calcitonin) in MEDLINE, Embase...
August 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28762126/systematic-scoping-review-of-patients-perceived-needs-of-health-services-for-osteoporosis
#15
REVIEW
L Chou, P Shamdasani, A M Briggs, F M Cicuttini, K Sullivan, K L M D Seneviwickrama, A E Wluka
Health service planners, administrators and providers need to understand the patients' perspective of health services related to osteoporosis to optimise health outcomes. The aims of this study were to systematically identify and review the literature regarding patients' perceived health service needs relating to osteoporosis and osteopenia. A systematic scoping review was performed of publications in MEDLINE, EMBASE, CINAHL and PsycINFO (1990-2016). Descriptive data regarding study design and methodology were extracted and risk of bias assessed...
July 31, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28756457/a-comparison-of-electronic-and-manual-fracture-risk-assessment-tools-in-screening-elderly-male-us-veterans-at-risk-for-osteoporosis
#16
S T Williams, P T Lawrence, K L Miller, J L Crook, J LaFleur, G W Cannon, R E Nelson
This study compares four screening tools in their ability to predict osteoporosis. We found that there was no significant difference between the tools. These results provide support for the use of automated screening tools which work in conjunction with the electronic medical record and help improve screening rates for osteoporosis. INTRODUCTION: The purpose of this study is to compare the performance of four fracture risk assessment tools (FRATs) in identifying osteoporosis by bone mineral density (BMD) T-score: Veterans Affairs Fracture Absolute Risk Assessment Tool (VA-FARA), World Health Organization's Fracture Risk Assessment Tool (FRAX), electronic FRAX (e-FRAX), and Osteoporosis Self-Assessment Screening Tool (OST)...
July 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28752332/adverse-bone-effects-of-medications-used-to-treat-non-skeletal-disorders
#17
REVIEW
N B Watts
There is a growing list of medications used to treat non-skeletal disorders that cause bone loss and/or increase fracture risk. This review discusses glucocorticoids, drugs that reduce sex steroids, antidiabetic agents, acid-reducing drugs, selective serotonin reuptake inhibitors, and heparin. A number of drugs are known to cause bone loss, increase fracture risk, or both. These drugs should be used in the lowest dose necessary to achieve the desired benefit and for the shortest time necessary, but in many cases, long-term treatment is required...
July 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28748389/predisposing-factors-associated-with-atypical-femur-fracture-among-postmenopausal-korean-women-receiving-bisphosphonate-therapy-8%C3%A2-years-experience-in-a-single-center
#18
J H Koh, J P Myong, J Yoo, Y-W Lim, J Lee, S-K Kwok, S-H Park, J H Ju
The risk factors for atypical femur fracture in patients exposed to bisphosphonates for at least 1 year were examined. Prolonged and continuous use of bisphosphonates, long-term use of glucocorticoids, and a higher body mass index were associated with increased risk of atypical femur fracture. INTRODUCTION: The purpose of the present study is to determine whether rheumatoid arthritis (RA) and other clinical factors are associated with an increased risk of bisphosphonate (BP)-related atypical femur fracture (AFF)...
July 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28748388/pls3-sequencing-in-childhood-onset-primary-osteoporosis-identifies-two-novel-disease-causing-variants
#19
A J Kämpe, A Costantini, R E Mäkitie, N Jäntti, H Valta, M Mäyränpää, H Kröger, M Pekkinen, F Taylan, H Jiao, O Mäkitie
Altogether 95 children with primary bone fragility were screened for variants in PLS3, the gene underlying X-linked osteoporosis. Two children with multiple peripheral and spinal fractures and low BMD had novel disease-causing PLS3 variants. Children with milder phenotypes had no pathogenic variants. PLS3 screening is indicated in childhood-onset primary osteoporosis. INTRODUCTION: The study aimed to determine the role of pathogenic PLS3 variants in children's bone fragility and to elucidate the associated phenotypic features...
July 26, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28748387/costs-of-fragility-hip-fractures-globally-a-systematic-review-and-meta-regression-analysis
#20
REVIEW
S Williamson, F Landeiro, T McConnell, L Fulford-Smith, M K Javaid, A Judge, J Leal
Purpose This study was conducted in order to systematically review the costs of hip fractures globally and identify drivers of differences in costs. Methods A systematic review was conducted to identify studies reporting patient level fragility hip fracture costs between 1990 and 2015. We extracted data on the participants and costs from these studies. Cost data concerning the index hospitalisation were pooled, and a meta-regression was used to examine its potential drivers. We also pooled data on the first-year costs following hip fracture and considered healthcare, social care as well as other cost categories if reported by studies...
July 26, 2017: Osteoporosis International
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