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Osteoporosis International

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https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#1
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774404/quality-indicators-for-hip-fracture-care-a-systematic-review
#2
REVIEW
S C Voeten, P Krijnen, D M Voeten, J H Hegeman, M W J M Wouters, I B Schipper
Quality indicators are used to measure quality of care and enable benchmarking. An overview of all existing hip fracture quality indicators is lacking. The primary aim was to identify quality indicators for hip fracture care reported in literature, hip fracture audits, and guidelines. The secondary aim was to compose a set of methodologically sound quality indicators for the evaluation of hip fracture care in clinical practice. A literature search according to the PRISMA guidelines and an internet search were performed to identify hip fracture quality indicators...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774403/anti-osteoporosis-drug-use-too-little-too-much-or-just-right-the-hunt-study-norway
#3
M Hoff, S Skurtveit, H E Meyer, A Langhammer, A J Søgaard, U Syversen, E Skovlund, B Abrahamsen, S Forsmo, B Schei
Use of anti-osteoporotic drugs (AODs) was examined in a Norwegian population 50-85 years. Among them with Fracture Risk Assessment Tool (FRAX) score for major osteoporotic fracture ≥ 20, 25% of the women and 17% of the men received AODs. The strongest predictors for AODs were high age in women and use of glucocorticoids among men. INTRODUCTION: To examine the use of anti-osteoporotic drugs (AODs) and to identify predictors for prescriptions. METHODS: Data were obtained from the Nord-Trøndelag Health Study (HUNT3) performed in 2006-2008 and the Norwegian Prescription Database, including 15,075 women and 13,386 men aged 50-85 years...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774402/subtrochanteric-and-diaphyseal-femoral-fractures-in-hypophosphatasia-not-atypical-at-all
#4
F Genest, L Seefried
Risk for subtrochanteric and diaphyseal femoral fractures is considered increased in patients with hypophosphatasia (HPP). Evaluating a large cohort of HPP patients, we could for the first time quantify the prevalcence and identify both morphometric features as well as predisposing factors for this complication of severe HPP. INTRODUCTION: Subtrochanteric and diaphyseal femoral fractures have been associated with both, long-term antiresorptive treatment and metabolic bone disorders, specifically Hypophosphatasia (HPP)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774401/high-levels-of-serum-sclerostin-and-dkk1-in-a-case-of-klippel-tr%C3%A3-naunay-syndrome
#5
P Muto, A Lo Gullo, G Mandraffino, S Loddo, M Atteritano
Klippel-Trénaunay syndrome (KTS) is described as a complex syndrome characterized by various combinations of capillary, venous, and lymphatic malformations associated with bone and soft tissue hypertrophy. We report a case of a 67-year-old postmenopausal Caucasian women with KTS that shows elevated levels of sclerostin and Dickkopf-related protein 1 (DKK1). Dual-energy X-ray absorptiometry (DXA) BMD T-scores at lumbar spine and femur were normal. Serum calcium and phosphorus levels were consistently normal, 25-hydroxyvitamin D (25OHD) < 30 ng/mL, and normal parathyroid hormone (PTH)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774400/cost-effectiveness-of-osteoporosis-screening-strategies-for-hip-fracture-prevention-in-older-chinese-people-a-decision-tree-modeling-study-in-the-mr-os-and-ms-os-cohort-in-hong-kong
#6
Y Su, F T T Lai, B H K Yip, J C S Leung, T C Y Kwok
Despite the high costs of hip fracture, many governments provide limited support for osteoporosis screening. We demonstrated that osteoporosis screening by dual-energy X-ray absorptiometry (DXA) with or without pre-screening by Fracture Risk Assessment Tool (FRAX) or calcaneal ultrasound are more cost-effective than no screening in Chinese people aged 65 or over in Hong Kong. INTRODUCTION: To examine the cost-effective potential osteoporosis screening strategies for hip fracture prevention in Hong Kong...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29744567/low-rates-of-osteoporosis-treatment-after-hospitalization-for-hip-fracture-in-hawaii
#7
E T Nguyen, T Posas-Mendoza, A M Siu, H J Ahn, S Y Choi, S Y Lim
We evaluated osteoporosis treatment and DEXA utilization rates of patients who were admitted for hip fracture in a single healthcare system in Hawaii from 2015 to 2016. We found that osteoporosis treatment and DEXA utilization rates were low, highlighting a critical gap in osteoporosis care after admission for hip fracture. INTRODUCTION: The objective of this study was to evaluate osteoporosis care after an admission for hip fracture at three community hospitals within a single healthcare system in Hawaii...
May 9, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29740667/benefits-and-safety-of-dietary-protein-for-bone-health-an-expert-consensus-paper-endorsed-by-the-european-society-for-clinical-and-economical-aspects-of-osteopororosis-osteoarthritis-and-musculoskeletal-diseases-and-by-the-international-osteoporosis-foundation
#8
REVIEW
R Rizzoli, E Biver, J-P Bonjour, V Coxam, D Goltzman, J A Kanis, J Lappe, L Rejnmark, S Sahni, C Weaver, H Weiler, J-Y Reginster
A summary of systematic reviews and meta-analyses addressing the benefits and risks of dietary protein intakes for bone health in adults suggests that dietary protein levels even above the current RDA may be beneficial in reducing bone loss and hip fracture risk, provided calcium intakes are adequate. Several systematic reviews and meta-analyses have addressed the benefits and risks of dietary protein intakes for bone health in adults. This narrative review of the literature summarizes and synthesizes recent systematic reviews and meta-analyses and highlights key messages...
May 8, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29737369/reduced-bone-mineral-density-in-human-immunodeficiency-virus-infected-individuals-a-meta-analysis-of-its-prevalence-and-risk-factors-supplementary-presentation
#9
EDITORIAL
S S L Goh, P S M Lai, A T B Tan, S Ponnampalavanar
A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary.
May 8, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29736760/assessment-of-bone-quality-in-patients-with-diabetes-mellitus
#10
REVIEW
N Jiang, W Xia
Substantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased bone fragility in diabetes. Bone density and quality are important determinants of bone strength. Although bone mineral density (BMD) and the fracture risk assessment tool (FRAX) are very useful clinical tools in assessing bone strength, they may underestimate the fracture risk in diabetes mellitus. Through advances in new technologies such as trabecular bone score (TBS) and peripheral quantitative computed tomography (pQCT), we can better assess the bone quality and fracture risk of patients with diabetes mellitus...
May 7, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29725715/fermented-dairy-products-consumption-is-associated-with-attenuated-cortical-bone-loss-independently-of-total-calcium-protein-and-energy-intakes-in-healthy-postmenopausal-women
#11
E Biver, C Durosier-Izart, F Merminod, T Chevalley, B van Rietbergen, S L Ferrari, R Rizzoli
A longitudinal analysis of bone microstructure in postmenopausal women of the Geneva Retirees Cohort indicates that age-related cortical bone loss is attenuated at non-bearing bone sites in fermented dairy products consumers, not in milk or ripened cheese consumers, independently of total energy, calcium, or protein intakes. INTRODUCTION: Fermented dairy products (FDP), including yogurts, provide calcium, phosphorus, and proteins together with prebiotics and probiotics, all being potentially beneficial for bone...
May 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29725714/at-what-price-decreased-mortality-risk-response-to-were-vcf-patients-at-higher-risk-of-mortality-following-the-2009-publication-of-the-vertebroplasty-sham-trials
#12
LETTER
A J Rodriguez, P R Ebeling
No abstract text is available yet for this article.
May 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29725713/reply-to-at-what-price-decreased-mortality-risk
#13
LETTER
K L Ong, D P Beall, M Frohbergh, E Lau, J A Hirsch
No abstract text is available yet for this article.
May 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29721575/iron-excess-upregulates-spns2-mrna-levels-but-reduces-sphingosine-1-phosphate-export-in-human-osteoblastic-mg-63-cells
#14
L Peltier, C Bendavid, T Cavey, M-L Island, M Doyard, P Leroyer, C Allain, M De Tayrac, M Ropert, O Loréal, P Guggenbuhl
We aimed to study the mechanisms involved in bone-related iron impairment by using the osteoblast-like MG-63 cell line. Our results indicate that iron impact the S1P/S1PR signalizing axis and suggest that iron can affect the S1P process and favor the occurrence of osteoporosis during chronic iron overload. INTRODUCTION: Systemic iron excess favors the development of osteoporosis, especially during genetic hemochromatosis. The cellular mechanisms involved are still unclear despite numerous data supporting a direct effect of iron on bone biology...
May 3, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29713799/genetic-profiling-of-decreased-bone-mineral-density-in-an-independent-sample-of-caucasian-women
#15
X Xiao, D Roohani, Q Wu
Genetic risk of low bone mineral density in women remains unclear. This study found that a large percentage of Caucasian women have a high genetic risk of osteoporosis, and genetic risk scores are significantly associated with BMD variation in a bone healthy sample of Caucasian women. INTRODUCTION: We aimed to examine the distribution of risk alleles in an independent sample and to determine if such genetic components are associated with bone mineral density (BMD) variation in the sample...
May 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29713798/hypocalcemia-and-bone-mineral-density-changes-following-denosumab-treatment-in-end-stage-renal-disease-patients-a-meta-analysis-of-observational-studies
#16
REVIEW
C Thongprayoon, P Acharya, C Acharya, J Chenbhanich, T Bathini, B Boonpheng, K Sharma, K Wijarnpreecha, P Ungprasert, M L Gonzalez Suarez, W Cheungpasitporn
The incidence of hypocalcemia and bone mineral density (BMD) changes in end-stage renal disease (ESRD) patients on denosumab remains unclear. We performed this meta-analysis to assess the incidence of denosumab-associated hypocalcemia and effects of denosumab on BMD in ESRD patients. A literature search was conducted using MEDLINE, EMBASE, and Cochrane Database from inception through November 2017 to identify studies evaluating incidence of denosumab-associated hypocalcemia and changes in serum calcium, phosphate, alkaline phosphatase (ALP), parathyroid hormone (PTH), and BMD from baseline to post-treatment course of denosumab in ESRD patients...
April 30, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29713797/whole-egg-consumption-and-cortical-bone-in-healthy-children
#17
L M Coheley, J M Kindler, E M Laing, A Oshri, K M Hill Gallant, S J Warden, M Peacock, C M Weaver, R D Lewis
Eggs contain bioactive compounds thought to benefit pediatric bone. This cross-sectional study shows a positive link between childhood egg intake and radius cortical bone. If randomized trials confirm our findings, incorporating eggs into children's diets could have a significant impact in preventing childhood fractures and reducing the risk of osteoporosis. INTRODUCTION: This study examined the relationships between egg consumption and cortical bone in children. METHODS: The cross-sectional study design included 294 9-13-year-old black and white males and females...
April 30, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29713796/is-calcifediol-better-than-cholecalciferol-for-vitamin-d-supplementation
#18
REVIEW
J M Quesada-Gomez, R Bouillon
Modest and even severe vitamin D deficiency is widely prevalent around the world. There is consensus that a good vitamin D status is necessary for bone and general health. Similarly, a better vitamin D status is essential for optimal efficacy of antiresorptive treatments. Supplementation of food with vitamin D or using vitamin D supplements is the most widely used strategy to improve the vitamin status. Cholecalciferol (vitamin D3 ) and ergocalciferol (vitamin D2 ) are the most widely used compounds and the relative use of both products depends on historical or practical reasons...
April 30, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29704027/implementation-of-the-western-australian-osteoporosis-model-of-care-a-fracture-liaison-service-utilising-emergency-department-information-systems-to-identify-patients-with-fragility-fracture-to-improve-current-practice-and-reduce-re-fracture-rates-a-12-month
#19
C A Inderjeeth, W D Raymond, A M Briggs, E Geelhoed, D Oldham, D Mountain
Fracture liaison service linked to an emergency department database effectively identifies patients with OP, improves best practice care, reduces recurrent fractures, and improves quality of life (QoL). The next step is to establish cost-effectiveness. This should be seen as the standard model of care. INTRODUCTION: The Western Australian Osteoporosis Model of Care recommends implementation of a fracture liaison service (FLS) to manage patients with minimal trauma fractures (MTFs). This study evaluates the efficacy of a FLS linked to a tertiary hospital emergency department information system (EDIS) in reducing recurrent fractures...
April 27, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29704026/the-relation-of-low-levels-of-bone-mineral-density-with-coronary-artery-calcium-and-mortality
#20
N Ahmadi, S S Mao, F Hajsadeghi, B Arnold, S Kiramijyan, Y Gao, F Flores, S Azen, M Budoff
Osteoporosis and atherosclerosis are two prevalent major healthcare concerns that frequently coexist. The clinical outcome of 5590 consecutive subjects who underwent coronary artery calcium (CAC) scanning and thoracic bone mineral density (BMD) measurement was assessed. A significant link between low BMD levels and CAC with increased risk of mortality in both genders across ethnicities noted. INTRODUCTION: While a relation of CAC with lower levels of BMD reported previously; it is unclear whether low levels of BMD would be an independent risk factor for CAC and mortality...
April 27, 2018: Osteoporosis International
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