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Osteoporosis International

C H Vala, V Sundh, D Mellström
No abstract text is available yet for this article.
May 22, 2017: Osteoporosis International
D Minkov
No abstract text is available yet for this article.
May 22, 2017: Osteoporosis International
X Liu, A H Villamagna, J W Yoo
No abstract text is available yet for this article.
May 18, 2017: Osteoporosis International
T Mori, C J Crandall, D A Ganz
No abstract text is available yet for this article.
May 18, 2017: Osteoporosis International
L Abderhalden, F M Weaver, M Bethel, H Demirtas, S Burns, J Svircev, H Hoenig, K Lyles, S Miskevics, L D Carbone
No abstract text is available yet for this article.
May 15, 2017: Osteoporosis International
S Sabour
No abstract text is available yet for this article.
May 13, 2017: Osteoporosis International
T Gulin, I Kruljac, L S Kirigin Biloš, M Gulin, M Grgurević, M Borojević
This study investigated the impact of anthropometric parameters, adiponectin, leptin, homeostatic model assessment for insulin resistance (HOMA-IR), beta-isomerised C-terminal telopeptide of collagen type I (β-CTX), and routine biochemical tests on one-year mortality in hip fracture patients. We found that male patients with high adiponectin, leptin, and β-CTX levels had a 5-fold increase in all-cause one-year mortality. INTRODUCTION: Several predictors of one-year hip fracture mortality have been identified including advanced age, male sex, low bone mineral density, and preexisting comorbidities...
May 13, 2017: Osteoporosis International
M J Pérez-Sáez, S Herrera, D Prieto-Alhambra, L Vilaplana, X Nogués, M Vera, D Redondo-Pachón, M Mir, R Güerri, M Crespo, A Díez-Pérez, J Pascual
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture's estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. INTRODUCTION: BMD measured by dual-energy X-ray absorptiometry (DXA) is used to assess bone health in end-stage renal disease (ESRD) patients...
May 11, 2017: Osteoporosis International
P Yin, H Lv, Y Li, Y Meng, L Zhang, P Tang
Controversy has arisen in regarding the association between serum uric acid (UA) and fracture risk. Therefore, we conducted a systemic review and meta-analysis by pooling estimate of five prospective studies (29,110 participants). Results showed that an increased serum UA level is associated with a lower risk of fracture. Numerous studies have demonstrated that high serum UA is a relevant risk factor for a wide variety of diseases, whereas new understanding in serum uric acid follows recent reports demonstrating a protective role of UA in health status...
May 9, 2017: Osteoporosis International
Y-C Lin, T-S Huang, J S Wu, Y-C Cheung, Y-H Huang, C-M Sung, Y-H Juan, F-P Chen, J M Ni Mhuircheartaigh
The purpose of this study is to assess the differences in VFA diagnostic accuracy when using bilateral decubitus views and whether diagnostic accuracy is affected by scoliosis. Our findings show that the current practice of performing only one side is valid; however, bilateral views can improve specificity in scoliosis. INTRODUCTION: The diagnostic accuracy of vertebral fracture assessment (VFA) can be influenced by poor patient position and scoliosis. This study aims to assess the differences in VFA diagnostic accuracy for right and left lateral decubitus views and the effect of scoliosis...
May 9, 2017: Osteoporosis International
H P Bögl, P Aspenberg, J Schilcher
We excised the fracture site in 8 patients with incomplete atypical femoral fractures by drilling an 11-mm-diameter hole. New bone formation could be seen in the hole within a normal time frame. Delayed healing of these fractures might be unrelated to an impaired capacity to form bone. INTRODUCTION: Incomplete atypical femoral fractures (undisplaced cracks) heal slowly or not at all, and often progress to a complete fracture with minimal trauma. The impaired healing has been attributed to an impaired biologic healing capacity related to bisphosphonate use, or, alternatively, to the mechanical environment within the fracture crack...
May 4, 2017: Osteoporosis International
L Panach, E Serna, J J Tarín, A Cano, M Á García-Pérez
This study represented a translational study that first compared gene expression of B cells of BM from ovariectomized and control mice, and then analyzed some of the differentially expressed genes in women. Results showed novel genetic associations with bone phenotypes and points to the CD80 gene as relevant in postmenopausal bone loss. INTRODUCTION: Osteoporosis is a multifactorial disease with a strong genetic component. However, to date, research into osteoporosis has only been able to explain a small part of its heritability...
May 2, 2017: Osteoporosis International
F Malgo, N A T Hamdy, S E Papapoulos, N M Appelman-Dijkstra
We evaluated the relationship between bone material strength index (BMSi) and fragility fractures, including vertebral fractures. Our data showed that BMSi is low in all fracture patients with low bone mass, independently of whether patients sustained a vertebral or a non-vertebral fracture. INTRODUCTION: Impact microindentation (IMI) is a new technique for the measurement of tissue level properties of cortical bone in vivo. Previous studies showed an association between BMSi and non-vertebral fractures, but an association with vertebral fractures is still being debated...
May 2, 2017: Osteoporosis International
P Peris, X Filella, A Monegal, N Guañabens, L Foj, M Bonet, D Boquet, E Casado, D Cerdá, A Erra, C Gómez-Vaquero, S Martínez, N Montalá, C Pittarch, E Kanterewicz, M Sala, X Suris, J L Carrasco
Determination of different forms of 25-OHD (total, free and bioavailable) in healthy young women does not offer additional advantages over standard 25-OHDT for evaluating vitamin D deficiency. In these subjects 25-OHDT values <15 ng/ml would be more appropriate for defining this deficiency. INTRODUCTION: Determination of 25-OH vitamin D serum levels (25-OHD) constitutes the method of choice for evaluating vitamin D deficiency. However, vitamin D-binding protein (DBP) may modulate its bioavailability thereby affecting correct evaluation of 25-OHD status...
May 2, 2017: Osteoporosis International
X Li, J-X Ye, M-H Xu, M-D Zhao, F-L Yuan
Activated acid-sensing ion channel 1a (ASIC1a) is involved in acid-induced osteoclastogenesis by regulating activation of the transcription factor NFATc1. These results indicated that ASIC1a activation by extracellular acid may cause osteoclast migration and adhesion through Ca(2+)-dependent integrin/Pyk2/Src signaling pathway. INTRODUCTION: Osteoclast adhesion and migration are responsible for osteoporotic bone loss. Acidic conditions promote osteoclastogenesis. ASIC1a in osteoclasts is associated with acid-induced osteoclastogenesis through modulating transcription factor NFATc1 activation...
May 1, 2017: Osteoporosis International
E Laird, A M Molloy, H McNulty, M Ward, K McCarroll, L Hoey, C F Hughes, C Cunningham, J J Strain, M C Casey
In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults. INTRODUCTION: The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA)...
May 1, 2017: Osteoporosis International
S Dombrowski, K Kostev, L Jacob
In type 2 diabetes patients treated in German primary care practices, the use of dipeptidyl peptidase-4 inhibitor (DPP4i) in combination with metformin was associated with a significant decrease in the risk of developing bone fractures compared to metformin monotherapy. INTRODUCTION: The goal of this study was to analyze the impact of dipeptidyl peptidase-4 inhibitor (DPP4i) use on the risk of bone fracture in patients diagnosed with type 2 diabetes mellitus (T2DM) in Germany. METHODS: Patients with an initial prescription of metformin between 2008 and 2014 from 1262 German general practitioner practices were selected...
April 29, 2017: Osteoporosis International
N R Jørgensen, L T Møllehave, Y B L Hansen, N Quardon, L Lylloff, A Linneberg
Bone turnover markers are used for monitoring osteoporosis treatment. Therefore, we evaluated the agreement between different assays for CTX and PINP and established reference intervals in a cohort of 2300 individuals. We found poor agreement between assays and different reference intervals. This highlights the importance of harmonization of the assays. INTRODUCTION: Two reference markers for bone turnover have been proposed: CTX bone resorption and P1NP for bone formation. The purpose of the current study was to establish reference intervals for the two markers in a Danish cohort and to determine the agreement on the two platforms...
April 28, 2017: Osteoporosis International
J A Kanis, C Cooper, R Rizzoli, B Abrahamsen, N M Al-Daghri, M L Brandi, J Cannata-Andia, B Cortet, H P Dimai, S Ferrari, P Hadji, N C Harvey, M Kraenzlin, A Kurth, E McCloskey, S Minisola, T Thomas, J-Y Reginster
Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future research. INTRODUCTION: The purpose of the study was to review data on the identification and treatment of patients with osteoporosis at increased risk of fracture...
April 27, 2017: Osteoporosis International
T Hasegawa, A Kawakita, N Ueda, R Funahara, A Tachibana, M Kobayashi, E Kondou, D Takeda, Y Kojima, S Sato, S Yanamoto, H Komatsubara, M Umeda, T Kirita, H Kurita, Y Shibuya, T Komori
Root amputation, extraction of a single tooth, bone loss or severe tooth mobility, and an unclosed wound were significantly associated with increased risk of developing medication-related osteonecrosis of the jaw (MRONJ). We recommend a minimally traumatic extraction technique, removal of any bone edges, and mucosal wound closure as standard procedures in patients receiving bisphosphonates. INTRODUCTION: Osteonecrosis of the jaws can occur following tooth extraction in patients receiving bisphosphonate drugs...
April 27, 2017: Osteoporosis International
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