journal
MENU ▼
Read by QxMD icon Read
search

Molecular and Cellular Neurosciences

journal
https://www.readbyqxmd.com/read/28536001/membrane-shaping-by-actin-and-myosin-during-regulated-exocytosis
#1
REVIEW
Andreas Papadopulos
The cortical actin network in neurosecretory cells is a dense mesh of actin filaments underlying the plasma membrane. Interaction of actomyosin with vesicular membranes or the plasma membrane is vital for tethering, retention, transport as well as fusion and fission of exo- and endocytic membrane structures. During regulated exocytosis the cortical actin network undergoes dramatic changes in morphology to accommodate vesicle docking, fusion and replenishment. Most of these processes involve plasma membrane Phosphoinositides (PIP) and investigating the interactions between the actin cortex and secretory structures has become a hotbed for research in recent years...
May 20, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28522364/inhibition-of-mir-181a-protects-female-mice-from-transient-focal-cerebral-ischemia-by-targeting-astrocyte-estrogen-receptor-%C3%AE
#2
Creed M Stary, Lijun Xu, Le Li, Xiaoyun Sun, Yi-Bing Ouyang, Xiaoxing Xiong, Jing Zhao, Rona G Giffard
Whether the effect of miR-181a is sexually dimorphic in stroke is unknown. Prior work showed protection of male mice with miR-181a inhibition. Estrogen receptor-α (ERα) is an identified target of miR181 in endometrium. Therefore we investigated the separate and joint effects of miR-181a inhibition and 17β-estradiol (E2) replacement after ovariectomy. Adult female mice were ovariectomized and implanted with an E2- or vehicle-containing capsule for 14d prior to 1h middle cerebral artery occlusion (MCAO). Each group received either miR-181a antagomir or mismatch control by intracerebroventricular injection 24h before MCAO...
May 15, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28506637/thiamine-and-benfotiamine-prevent-stress-induced-suppression-of-hippocampal-neurogenesis-in-mice-exposed-to-predation-without-affecting-brain-thiamine-diphosphate-levels
#3
Julie Vignisse, Margaux Sambon, Anna Gorlova, Dmitrii Pavlov, Nicolas Caron, Brigitte Malgrange, Elena Shevtsova, Andrey Svistunov, Daniel C Anthony, Natalyia Markova, Natalyia Bazhenova, Bernard Coumans, Bernard Lakaye, Pierre Wins, Tatyana Strekalova, Lucien Bettendorff
Thiamine is essential for normal brain function and its deficiency causes metabolic impairment, specific lesions, oxidative damage and reduced adult hippocampal neurogenesis (AHN). Thiamine precursors with increased bioavailability, especially benfotiamine, exert neuroprotective effects not only for thiamine deficiency (TD), but also in mouse models of neurodegeneration. As it is known that AHN is impaired by stress in rodents, we exposed C57BL6/J mice to predator stress for 5 consecutive nights and studied the proliferation (number of Ki67-positive cells) and survival (number of BrdU-positive cells) of newborn immature neurons in the subgranular zone of the dentate gyrus...
May 12, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28495450/rho-guanine-nucleotide-exchange-factor-rgnef-is-a-prosurvival-factor-under-stress-conditions
#4
Kevin Cheung, Cristian A Droppelmann, Adam MacLellan, Ian Cameron, Benjamin Withers, Danae Campos-Melo, Kathryn Volkening, Michael J Strong
Rho guanine nucleotide exchange factor (RGNEF) is a 190kDa RNA binding protein (RBP) that also contains a Dbl/PH domain capable of RhoA activation. Consistent with a key role in the pathogenesis of amyotrophic lateral sclerosis (ALS), RGNEF forms pathological neuronal cytoplasmic inclusions in degenerating spinal motor neurons. To further understand the role of RGNEF in the stress response, we first observed that the expression of RGNEF is upregulated in murine spinal motor neurons following distal sciatic nerve injury...
May 8, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28479292/new-waves-in-dendritic-spine-actin-cytoskeleton-from-branches-and-bundles-to-rings-from-actin-binding-proteins-to-post-translational-modifications
#5
REVIEW
Enni Bertling, Pirta Hotulainen
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the postsynaptic part of most excitatory synapses. Changes in the number or strength of synapses are physiological mechanisms behind learning. The growth and maturation of dendritic spines and the activity-induced changes to their morphology are all based on changes to the actin cytoskeleton. In this review, we will discuss the regulation of the actin cytoskeleton in dendritic spine formation and maturation, as well as in synaptic strengthening...
May 4, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28477983/retinoic-acid-increases-glucocorticoid-receptor-phosphorylation-via-cyclin-dependent-kinase-5
#6
Julie Brossaud, Hélène Roumes, Jean-Christophe Helbling, Marie-Pierre Moisan, Véronique Pallet, Guillaume Ferreira, Essi-Fanny Biyong, Anabelle Redonnet, Jean-Benoît Corcuff
Glucocorticoid receptor (GR) function is modulated by phosphorylation. As retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR, we investigated whether RA could modulate GR phosphorylation in neuronal cells in a context of long-term glucocorticoid exposure. A 4-day treatment of dexamethasone (Dex) plus RA, showed that RA potentiated the (Dex)-induced phosphorylation on GR Serine 220 (pSer220GR) in the nucleus of a hippocampal HT22 cell line. This treatment increased the cytoplasmic ratio of p35/p25 proteins, which are major CDK5 cofactors...
May 3, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28476540/epigenetic-and-transcriptional-modulation-of-wdr5-a-chromatin-remodeling-protein-in-huntington-s-disease-human-induced-pluripotent-stem-cell-hipsc-model
#7
Simona Baronchelli, Alberto La Spada, Aikaterini Ntai, Andrea Barbieri, Paola Conforti, Gloria Saccani Jotti, Serena Redaelli, Angela Bentivegna, Pasquale De Blasio, Ida Biunno
DNA methylation (DNAm) changes are of increasing relevance to neurodegenerative disorders, including Huntington's disease (HD). We performed genome-wide screening of possible DNAm changes occurring during striatal differentiation in human induced pluripotent stem cells derived from a HD patient (HD-hiPSCs) as cellular model. We identified 240 differentially methylated regions (DMRs) at promoters in fully differentiated HD-hiPSCs. Subsequently, we focused on the methylation differences in a subcluster of genes related to Jumonji Domain Containing 3 (JMJD3), a demethylase that epigenetically regulates neuronal differentiation and activates neuronal progenitor associated genes, which are indispensable for neuronal fate acquisition...
May 2, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28465254/activation-of-adenosine-a2a-receptor-signaling-regulates-the-expression-of-cytokines-associated-with-immunologic-dysfunction-in-btbr-t-itpr3-tf-j-mice
#8
Mushtaq A Ansari, Sabry M Attia, Ahmed Nadeem, Saleh A Bakheet, Mohammad Raish, Tajdar H Khan, Othman A Al-Shabanah, Sheikh F Ahmad
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by stereotypical repetitive behavior, impaired social interaction, and deficits in communication. The BTBR T(+) Itpr3(tf)/J (BTBR) mice have been extensively used as an animal model of the ASD-like phenotype. Adenosine A2A receptors (A2ARs) are considered potential targets in the treatment of neurodegenerative diseases. In this study, we used the A2AR antagonist SCH 5826 (SCH) and the A2AR agonist CGS 21680 (CGS) to investigate the activation of A2AR signaling in immune cells...
April 30, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28461219/divergent-lactate-dehydrogenase-isoenzyme-profile-in-cellular-compartments-of-primate-forebrain-structures
#9
Tetyana Duka, Zachary Collins, Sarah M Anderson, Mary Ann Raghanti, John J Ely, Patrick R Hof, Derek E Wildman, Morris Goodman, Lawrence I Grossman, Chet C Sherwood
The compartmentalization and association of lactate dehydrogenase (LDH) with specific cellular structures (e.g., synaptosomal, sarcoplasmic or mitochondrial) may play an important role in brain energy metabolism. Our previous research revealed that LDH in the synaptosomal fraction shifts toward the aerobic isoforms (LDH-B) among the large-brained haplorhine primates compared to strepsirrhines. Here, we further analyzed the subcellular localization of LDH in primate forebrain structures using quantitative Western blotting and ELISA...
April 29, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28461220/delineating-neurotrophin-3-dependent-signaling-pathways-underlying-sympathetic-axon-growth-along-intermediate-targets
#10
Austin B Keeler, Dong Suo, Juyeon Park, Christopher D Deppmann
Postganglionic sympathetic neurons detect vascular derived neurotrophin 3 (NT3) via the axonally expressed receptor tyrosine kinase, TrkA, to promote chemo-attraction along intermediate targets. Once axons arrive to their final target, a structurally related neurotrophic factor, nerve growth factor (NGF), also acts through TrkA to promote final target innervation. Does TrkA signal differently at these different locales? We previously found that Coronin-1 is upregulated in sympathetic neurons upon exposure to NGF, thereby endowing the NGF-TrkA complex with new signaling capabilities (i...
April 28, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28450268/extensive-uptake-of-%C3%AE-synuclein-oligomers-in-astrocytes-results-in-sustained-intracellular-deposits-and-mitochondrial-damage
#11
Veronica Lindström, Gabriel Gustafsson, Laurie H Sanders, Evan H Howlett, Jessica Sigvardson, Alex Kasrayan, Martin Ingelsson, Joakim Bergström, Anna Erlandsson
The presence of Lewy bodies, mainly consisting of aggregated α-synuclein, is a pathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The α-synuclein inclusions are predominantly found in neurons, but also appear frequently in astrocytes. However, the pathological significance of α-synuclein inclusions in astrocytes and the capacity of glial cells to clear toxic α-synuclein species remain unknown. In the present study we investigated uptake, degradation and toxic effects of oligomeric α-synuclein in a co-culture system of primary neurons, astrocytes and oligodendrocytes...
April 24, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28442364/effects-of-repeated-cocaine-exposure-and-withdrawal-on-voluntary-ethanol-drinking-and-the-expression-of-glial-glutamate-transporters-in-mesocorticolimbic-system-of-p-rats
#12
Alaa M Hammad, Yusuf S Althobaiti, Sujan C Das, Youssef Sari
Glutamatergic neurotransmission within the brain's reward circuits plays a major role in the reinforcing properties of both ethanol and cocaine. Glutamate homeostasis is regulated by several glutamate transporters, including glutamate transporter type 1 (GLT-1), cystine/glutamate transporter (xCT), and glutamate aspartate transporter (GLAST). Cocaine exposure has been shown to induce a dysregulation in glutamate homeostasis and a decrease in the expression of GLT-1 and xCT in the nucleus accumbens (NAc). In this study, alcohol preferring (P) rats were exposed to free-choice of ethanol (15% and 30%) and/or water for five weeks...
April 22, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28438696/altered-temporal-lobe-white-matter-lipid-ion-profiles-in-an-experimental-model-of-sporadic-alzheimer-s-disease
#13
Ming Tong, Raiane Leão, Gina V Vimbela, Emine B Yalcin, Jared Kay, Alexander Krotow, Suzanne M de la Monte
BACKGROUND: White matter is an early and important yet under-evaluated target of Alzheimer's disease (AD). Metabolic impairments due to insulin and insulin-like growth factor resistance contribute to white matter degeneration because corresponding signal transduction pathways maintain oligodendrocyte function and survival. METHODS: This study utilized a model of sporadic AD in which adult Long Evans rats administered intracerebral streptozotocin (i.c. STZ) developed AD-type neurodegeneration...
April 21, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28433463/actin-regulation-by-tropomodulin-and-tropomyosin-in-neuronal-morphogenesis-and-function
#14
REVIEW
Kevin T Gray, Alla S Kostyukova, Thomas Fath
Actin is a profoundly influential protein; it impacts, among other processes, membrane morphology, cellular motility, and vesicle transport. Actin can polymerize into long filaments that push on membranes and provide support for intracellular transport. Actin filaments have polar ends: the fast-growing (barbed) end and the slow-growing (pointed) end. Depolymerization from the pointed end supplies monomers for further polymerization at the barbed end. Tropomodulins (Tmods) cap pointed ends by binding onto actin and tropomyosins (Tpms)...
April 19, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28427888/dopamine-elevates-intracellular-zinc-concentration-in-cultured-rat-embryonic-cortical-neurons-through-the-camp-nitric-oxide-signaling-cascade
#15
Hui-Hsing Hung, Lung-Sen Kao, Pei-Shan Liu, Chien-Chang Huang, De-Ming Yang, Chien-Yuan Pan
Zinc ion (Zn(2+)), the second most abundant transition metal after iron in the body, is essential for neuronal activity and also induces toxicity if the concentration is abnormally high. Our previous results show that exposure of cultured cortical neurons to dopamine elevates intracellular Zn(2+) concentrations ([Zn(2+)]i) and induces autophagosome formation but the mechanism is not clear. In this study, we characterized the signaling pathway responsible for the dopamine-induced elevation of [Zn(2+)]i and the effect of [Zn(2+)]i in modulating the autophagy in cultured rat embryonic cortical neurons...
April 17, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28414095/crosstalk-control-and-limits-of-physiological-c-jun-n-terminal-kinase-activity-for-cell-viability-and-neurite-stability-in-differentiated-pc12-cells
#16
Vicki Waetzig, Milana Belzer, Wiebke Haeusgen, Ruwen Boehm, Ingolf Cascorbi, Thomas Herdegen
The c-Jun N-terminal kinases (JNKs) are important mediators of cell viability and structural integrity in postmitotic neurons, which is required for maintaining synaptic connections and neural plasticity. In the present study, we chose differentiated PC12 cells as a well-characterised neuronal model system to selectively examine the regulation of basal JNK activity by extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt. We detected a complex interaction between the kinases to prevent cell death and neurite loss...
April 14, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28414096/lysine-specific-demethylase-1-lsd1-depletion-disrupts-monogenic-and-monoallelic-odorant-receptor-or-expression-in-an-olfactory-neuronal-cell-line
#17
Rutesh N Vyas, Diane Meredith, Robert P Lane
Function of the mammalian olfactory system depends on specialized olfactory sensory neurons (OSNs) that each express only one allele ("monoallelic") of one odorant receptor (OR) gene ("monogenic"). The lysine-specific demethylase-1 (LSD1) protein removes activating H3K4 or silencing H3K9 methylation marks in a variety of developmental contexts, and is thought to be important for proper OR regulation. Most of the focus in the field has been on a potential "activating" function for LSD1; e.g., in the demethylation of H3K9 associated with the expressed OR allele...
April 13, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28404507/paclitaxel-inhibits-the-activity-and-membrane-localization-of-pkc%C3%AE-and-pkc%C3%AE-i-ii-to-elicit-a-decrease-in-stimulated-calcitonin-gene-related-peptide-release-from-cultured-sensory-neurons
#18
Lisa M Darby, Hongdi Meng, Jill C Fehrenbacher
Peripheral neuropathy is a dose-limiting and debilitating side effect of the chemotherapeutic drug, paclitaxel. Consequently, elucidating the mechanisms by which this drug alters sensory neuronal function is essential for the development of successful therapeutics for peripheral neuropathy. We previously demonstrated that chronic treatment with paclitaxel (3-5days) reduces neuropeptide release stimulated by agonists of TRPV1. Because the activity of TRPV1 channels is modulated by conventional and novel PKC isozymes (c/nPKC), we investigated whether c/nPKC mediate the loss of neuropeptide release following chronic treatment with paclitaxel (300nM; 3 and 5days)...
April 9, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28385508/molecular-and-cellular-neuroscience-special-issue
#19
EDITORIAL
Takeshi Sakurai, Alexander Dityatev, Andreas Faissner, Fritz Rathjen, Esther Stoeckli, Gianfranco Gennarini, Andrew Furley, Daniela Puzzo, Peter Burbach
No abstract text is available yet for this article.
April 3, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28363876/neuronal-polarization-from-spatiotemporal-signaling-to-cytoskeletal-dynamics
#20
REVIEW
Max Schelski, Frank Bradke
Neuronal polarization establishes distinct molecular structures to generate a distinct axon and multiple dendrites. Studies over the past years indicate that this efficient separation is brought about by a network of feedback loops. Axonal growth seems to play a major role in fueling those feedback loops and thereby stabilizing neuronal polarity. Indeed, various effectors involved in feedback loops play key roles in axonal growth by ultimately acting on the actin and microtubule cytoskeleton. These effectors have key roles in interconnecting actin and microtubule dynamics - a mechanism crucial to commanding the growth of axons...
March 28, 2017: Molecular and Cellular Neurosciences
journal
journal
30591
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"