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International Journal of Experimental Pathology

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https://www.readbyqxmd.com/read/29781539/intermittent-resistance-exercise-and-obesity-considered-separately-or-combined-impair-spermatic-parameters-in-adult-male-wistar-rats
#1
Ana Paula Franco Punhagui, Giovana Rampazzo Teixeira, Marcelo Conrado de Freitas, Patricia Monteiro Seraphim, Glaura Scantamburlo Alves Fernandes
Obesity and absence of physical exercise are global problems that affect concentration and sperm quality in the male reproductive system. The purpose of this study was to examine the effect of obesity and resistance training, considered separately or in association, on testicular function and reproductive capacity. Twenty pubertal male Wistar rats were distributed into four groups: control (C) and exercise (E) groups that received standard rat chow; and obese (O) and obese with exercise (OE) groups that received a high-fat diet...
May 21, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29671911/charting-the-unexplored-extracellular-matrix-in-cancer
#2
REVIEW
Elysse C Filipe, Jessica L Chitty, Thomas R Cox
The extracellular matrix (ECM) is present in all solid tissues and considered a master regulator of cell behaviour and phenotype. The importance of maintaining the correct biochemical and biophysical properties of the ECM, and the subsequent regulation of cell and tissue homeostasis, is illustrated by the simple fact that the ECM is highly dysregulated in many different types of disease, especially cancer. The loss of tissue ECM homeostasis and integrity is seen as one of the hallmarks of cancer and typically defines transitional events in progression and metastasis...
April 19, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29665181/mir-193a-3p-functions-as-a-tumour-suppressor-in-human-aldosterone-producing-adrenocortical-adenoma-by-down-regulating-cyp11b2
#3
Guoxi Zhang, Xiaofeng Zou, Quanliang Liu, Tianpeng Xie, Ruohui Huang, Huan Kang, Changfu Lai, Jiaxing Zhu
The mechanism of aldosterone-producing adrenocortical adenoma (APA) pathogenesis and the role of microRNAs (miRNAs) in APA pathogenesis have not been completely clarified. We examined the expression and function of miR-140-3p, miR-193a-3p and miR-22-3p, which have binding sites in CYP11B2. Expression of miRNAs and CYP11B2 mRNA was measured by quantitative reverse transcription PCR (qRT-PCR). Cell proliferation was monitored by colorimetric analysis, and cell apoptosis and cell cycle progression were analysed by flow cytometry...
April 17, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29665129/overexpression-of-epidermal-growth-factor-receptor-and-its-downstream-effector-focal-adhesion-kinase-correlates-with-papillary-thyroid-carcinoma-progression
#4
Sonja Šelemetjev, Aleksandar Bartolome, Tijana Išić Denčić, Ilona Đorić, Ivan Paunović, Svetislav Tatić, Dubravka Cvejić
Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting...
April 17, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29656466/evaluation-of-high-fat-high-fructose-diet-treatment-in-factor-viii-coagulation-factor-deficient-mouse-model
#5
Alaknanda Mishra, Shailendra Arindkar, Preeti Sahay, Jerald Mahesh Kumar, Pramod K Upadhyay, Subeer S Majumdar, Perumal Nagarajan
Non-alcoholic fatty liver disease (NAFLD)-like conditions enhance the production and action of clotting factors in humans. However, studies examining the effect of NAFLD due to high-fat high-fructose (HFHF) diet in factor VIII-deficient (haemophilia A) animals or patients have not been reported previously. In this study, we investigated the individual role of factor VIII in the progression of diet-induced NAFLD in the factor 8-/- (F8-/- ) mouse model system and its consequences on the haemophilic status of the mice...
April 15, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29655286/reduced-expression-of-oestrogen-receptor-%C3%AE-is-associated-with-tumour-invasion-and-metastasis-in-oestrogen-receptor-%C3%AE-negative-human-papillary-thyroid-carcinoma
#6
Wen-Wu Dong, Jian Li, Jing Li, Ping Zhang, Zhi-Hong Wang, Wei Sun, Hao Zhang
Oestrogens play an important role in the development and progression of papillary thyroid carcinoma (PTC) through oestrogen receptor (ER)-α and -β, which may exert different or even opposing actions in PTC. The roles of ERβ in ERα-negative PTC are still not clear. This study investigated the expression dynamics of ERβ1 (wild-type ERβ) and its clinical significance in female ERα-negative PTC patients. ERβ1 expression was detected in thyroid tissues of 136 female patients diagnosed with PTC. The relationships between ERβ1 expression and clinicopathological/biological factors were also analysed in female ERα-negative PTC patients...
April 14, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29577471/focal-but-not-global-cerebral-ischaemia-causes-loss-of-myenteric-neurons-and-upregulation-of-vasoactive-intestinal-peptide-in-mouse-ileum
#7
Xiaowen Cheng, Martina Svensson, Yiyi Yang, Tomas Deierborg, Eva Ekblad, Ulrikke Voss
Reduced blood flow to the brain induces cerebral ischaemia, potentially causing central injury and peripheral complications including gastrointestinal (GI) dysfunction. The pathophysiology behind GI symptoms is suspected to be neuropathy in the enteric nervous system (ENS), which is essential in regulating GI function. This study investigates if enteric neuropathy occurs after cerebral ischaemia, by analysing neuronal survival and relative numbers of vasoactive intestinal peptide (VIP) and neuronal nitric oxide synthase (nNOS) expressing neurons in mouse ileum after three types of cerebral ischaemia...
March 25, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29573490/extracellular-matrix-internalization-links-nutrient-signalling-to-invasive-migration
#8
REVIEW
Elena Rainero
Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others have shown that integrin can be endocytosed together with their ECM ligands. In this short review, I will highlight how extracellular protein (including ECM) endocytosis impinges on the activation of the mechanistic target of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth...
March 24, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29479759/mild-diabetes-long-term-effects-on-gastric-motility-evaluated-in-rats
#9
Andrieli T Hauschildt, Luciana A Corá, Gustavo T Volpato, Yuri K Sinzato, Débora C Damasceno, Madileine F Américo
Moderate hyperglycaemic levels seem to be related to abnormal gastric motility in diabetes mellitus. However, experimental models designed to evaluate the relationship between motility and diabetes over time are not yet well established. Our objective was to investigate the long-term effects of mild diabetes on gastric motility in rats. Newborn male rats received streptozotocin (mild diabetes groups - MD) or vehicle (control groups - C), and both groups were evaluated after 3 (C3 and MD3) and 6 months (C6 and MD6) postinduction...
February 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29479754/correlation-between-testicular-mast-cell-count-and-spermatogenic-epithelium-in-non-obstructive-azoospermia
#10
Ahmed A M Abdel-Hamid, Hoda Atef, Khaled R Zalata, Atef Abdel-Latif
Although there is emerging evidence that mast cells are involved in infertility, their exact role has not been elucidated clearly. Here we carried out a retrospective case-control study to find out whether there is a correlation between mast cell (MC) count and proliferation (Ki67 index) of the spermatogenic epithelium as well as of the Sertoli cells (vimentin-positive) in non-obstructive azoospermia (NOA). We assessed MCs, Ki67 and vimentin expression in Sertoli cells in testicular biopsies of germ cell aplasia (GCA, n = 14) and maturation arrest (MA, n = 14) vs...
February 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29473241/immunohistochemical-assessment-of-survivin-and-bcl3-expression-as-potential-biomarkers-for-nf-%C3%AE%C2%BAb-activation-in-the-barrett-metaplasia-dysplasia-adenocarcinoma-sequence
#11
Ignazio Puccio, Saif Khan, Adil Butt, David Graham, Vinay Sehgal, Dominic Patel, Marco Novelli, Laurence B Lovat, Manuel Rodriguez-Justo, Rifat A Hamoudi
Non-dysplastic Barrett's oesophagus (NDBE) occurs as a consequence of an inflammatory response triggered through prolonged gastro-oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. NF-κB activation as a result of the inflammatory response has been shown in NDBE, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for NF-κB activation along the oesophageal metaplasia-dysplasia-adenocarcinoma sequence...
February 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29349896/treatment-with-low-doses-of-aspirin-during-chronic-phase-of-experimental-chagas-disease-increases-oesophageal-nitrergic-neuronal-subpopulation-in-mice
#12
Cristina Lorena Massocatto, Neide Martins Moreira, Eliane Muniz, Silvana Marques de Araújo, Phileno Pinge-Filho, Robson Marcelo Rossi, Eduardo José de Almeida Araújo, Débora de Mello Gonçales Sant'ana
Patients with Chagas' disease may develop dysfunctions of oesophageal and colonic motility resulting from the degeneration or loss of the myenteric neurons of the enteric nervous system. Studies have shown that the use of aspirin, also known as acetylsalicylic acid (ASA), influences the pathogenesis of the disease. However, this remains controversial. The aim of this study was to evaluate the consequences of treatment with low doses of aspirin during the chronic phase of Chagas' disease on oesophageal function...
December 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29315931/histopathological-and-immunohistochemical-characterization-of-burkholderia-pseudomallei-lesions-in-an-acute-model-of-infection-with-balb-c-mice
#13
Waldo Luis García-Jiménez, Francisco J Salguero, Riccardo V D'Elia
Organ tissue damage is a key contributor to host morbidity and mortality following infection with microbial agents. Severe immune responses, excessive cellular recruitment and necrosis of cells all play a role in disease pathology. Understanding the pathogenesis of disease can aid in identifying potential new therapeutic targets or simply act as a diagnostic tool. Burkholderia pseudomallei is a Gram-negative bacterium that can cause acute and chronic diseases. The BALB/c mouse has been shown to be highly susceptible to aerosol challenge with B...
December 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29315911/promoter-hypermethylation-of-sox11-correlates-with-adverse-clinicopathological-features-of-human-prostate-cancer
#14
Apiwat Pugongchai, Andrey Bychkov, Pichet Sampatanukul
Currently available tools for early diagnosis and prognosis of prostate cancer lack sufficient accuracy. There is a need to identify novel biomarkers for this common malignancy. SOX family genes play an important role in embryogenesis and are also implicated in various cancers. SOX11 has been recently recognized as a potential tumour suppressor that is downregulated in prostate cancer. We hypothesized that hypermethylation may be responsible for SOX11 silencing in human prostate cancer. The aim of the study was to investigate SOX11 promoter methylation in prostate adenocarcinoma by comparing it with benign prostatic hyperplasia (BPH)...
December 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29285813/resveratrol-attenuates-reproductive-alterations-in-type-1-diabetes-induced-rats
#15
Joana Noguères Simas, Talita Biude Mendes, Camila Cicconi Paccola, Vanessa Vendramini, Sandra Maria Miraglia
The progression of diabetes mellitus leads to several complications including overproduction of reactive oxygen species and reproductive alterations. As resveratrol (RES) is a powerful anti-oxidant and an anti-apoptotic compound, we hypothesized that side effects of type-1 diabetes (DM1) on male reproduction could be reduced by the RES treatment. Eighty-four prepubertal male rats were distributed into seven groups: sham-control (SC), RES-treated (R), resveratrol-vehicle-treated (RV), diabetic (D), diabetic-insulin-treated (DI), diabetic-RES-treated (DR), diabetic-insulin and RES-treated (DIR)...
December 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29226508/glucose-homeostasis-in-two-degrees-of-sepsis-lethality-induced-by-caecum-ligation-and-puncture-in-mice
#16
Francielle B D Ferreira, Cristiane Dos Santos, Maciel A Bruxel, Everson A Nunes, Fernando Spiller, Alex Rafacho
Sepsis is associated with high mortality. Both critically ill humans and animal models of sepsis exhibit changes in their glucose homeostasis, that is, hypoglycaemia, with the progression of infection. However, the relationship between basal glycaemia, glucose tolerance and insulin sensitivity is not well understood. Thus, we aimed to evaluate this glucose homeostasis triad at the late stage of sepsis (24 h after surgery) in male Swiss mice subjected to lethal and sublethal sepsis by the caecal ligation and puncture (CLP) model...
December 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29280285/treatment-related-changes-after-short-term-exposure-of-sd-rats-to-aloe-vera-whole-leaf-freeze-dried-powder
#17
Tao Chen, Li Wang, Chunyan Hu
Aloe vera is a widely used natural herb from which many sorts of commercial products have been derived using different preparation technologies. Aloe whole-leaf powder is one of the most popular subtypes. The long-term impact of aloe products has already been reported; however, there have been few studies about short-term exposure, and especially about the relative impact of Aloe vera whole-leaf freeze-dried powder (AWFP). To provide more toxicological data and to document the early changes induced by AWFP, in this study 120 SD rats were divided into four groups (control and 400/1200/2000 mg/kg treatment groups) and were administered AWFP once daily by oral gavage for 28 consecutive days, followed by a two week recovery phase...
October 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29210119/diets-rich-in-saturated-fat-and-fructose-induce-anxiety-and-depression-like-behaviours-in-the-rat-is-there-a-role-for-lipid-peroxidation
#18
Silvia Gancheva, Bistra Galunska, Maria Zhelyazkova-Savova
Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water...
October 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29205609/effect-of-tamoxifen-on-fibrosis-collagen-content-and-transforming-growth-factor-%C3%AE-1-%C3%AE-2-and-%C3%AE-3-expression-in-common-bile-duct-anastomosis-of-pigs
#19
Orlando Hiroshi Kiono Siqueira, Karen Jesus Oliveira, Angela Cristina Gouvêa Carvalho, Antonio Claudio Lucas da Nóbrega, Renata Frauches Medeiros, Bruno Felix-Patrício, Fábio Otero Áscoli, Beni Olej
End-to-end anastomosis in the treatment for bile duct injury during laparoscopic cholecystectomy has been associated with stricture formation. The aim of this study was to experimentally investigate the effect of oral tamoxifen (tmx) treatment on fibrosis, collagen content and transforming growth factor-β1, -β2 and -β3 expression in common bile duct anastomosis of pigs. Twenty-six pigs were divided into three groups [sham (n = 8), control (n = 9) and tmx (n = 9)]. The common bile ducts were transected and anastomosed in the control and tmx groups...
October 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29205589/carnosine-decreased-oxidation-and-glycation-products-in-serum-and-liver-of-high-fat-diet-and-low-dose-streptozotocin-induced-diabetic-rats
#20
Abdurrahman Fatih Aydın, İlknur Bingül, Canan Küçükgergin, Işın Doğan-Ekici, Semra Doğru Abbasoğlu, Müjdat Uysal
High-fat diet (HFD) and low-dose streptozotocin (STZ)-treated rats provide useful animal model for type II diabetes mellitus. Oxidative stress and advanced glycation end products (AGEs) play a role in the development of diabetic complications. Carnosine (CAR) has anti-oxidant and anti-glycating properties. We investigated the effects of CAR on oxidation and glycation products in HFD+STZ rats. Rats were fed with HFD (60% of total calories from fat) for 4 weeks, and then a single dose of STZ (40 mg/kg; i.p...
October 2017: International Journal of Experimental Pathology
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