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International Journal of Experimental Pathology

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https://www.readbyqxmd.com/read/28621016/acute-effects-of-phenylbutyrate-on-glutamine-branched-chain-amino-acid-and-protein-metabolism-in-skeletal-muscles-of-rats
#1
Milan Holecek, Melita Vodenicarovova, Pavel Siman
Phenylbutyrate (PB) acts as chemical chaperone and histone deacetylase inhibitor, which is used to decrease ammonia in urea cycle disorders and has been investigated for use in the treatment of a number of lethal illnesses. We performed in vivo and in vitro experiments to examine the effects of PB on glutamine (GLN), branched-chain amino acid (BCAA; valine, leucine and isoleucine) and protein metabolism in rats. In the first study, animals were sacrificed one hour after three injections of PB (300mg/kg b...
June 16, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28585282/models-to-define-the-stages-of-articular-cartilage-degradation-in-osteoarthritis-development
#2
REVIEW
Blandine Poulet
Osteoarthritis (OA) is a common chronic disorder that affects an increasing number of the ageing population. Despite the prevalence, there are currently no therapies. Defining new therapies that target specific pathogenic phases of disease development relies on the effective separation of the different stages of OA. This manuscript reviews the tissues and models that are being used to separate these stages of disease, in particular initiation and early and late progression. These models include human tissues with known initiating factors, the use of anatomical locations with defined relationships to the primary cartilage lesion area, timing of OA development in well-described animal models and the versatility of a non-invasive model of murine knee joint trauma...
June 5, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28581201/grape-juice-concentrate-alleviates-epididymis-and-sperm-damage-in-cadmium-intoxicated-rats
#3
Celina de A Lamas, Livia Cuquetto-Leite, Emanueli do Nascimento da Silva, Bruna F Thomazini, Gabriel da S Cordeiro, Fabrícia de S Predes, Andrea P B Gollücke, Heidi Dolder
The possibility of long-term grape juice concentrate (GJC) consumption conferring a protective effect against cadmium (Cd)-induced damage to the epididymis, completely preserving sperm profile, was evaluated here for the first time in the scientific literature. Male Wistar rats (n = 6/per group) received an intraperitoneal Cd injection (1.2 mg/Kg) at age 80 days and GJC (2 g/Kg) by gavage from 50 days until 136 days old. Groups receiving either Cd or GJC were added. An intraperitoneal injection of saline (0...
June 5, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28580701/identification-of-dj-1-as-a-contributor-to-multidrug-resistance-in-human-small-cell-lung-cancer-using-proteomic-analysis
#4
Hongyi Gao, Yuchun Niu, Man Li, Shun Fang, Linlang Guo
Proteomic approaches have been proven to provide an important tool in identifying drug resistance-associated proteins. The aim of this study was to investigate the protein profiling of drug resistance-related proteins in small-cell lung cancer (SCLC) by proteomic analysis. The proteomic profiling was performed by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with MALDI-TOF-TOF of SCLC in the multidrug-resistant cell line H69AR and its parental cell line H69. A total of 11 proteins were identified to be >2-fold up-or downregulated between the two cell lines...
June 5, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28556971/low-level-laser-therapy-780%C3%A2-nm-combined-with-collagen-sponge-scaffold-promotes-repair-of-rat-cranial-critical-size-defects-and-increases-tgf-%C3%AE-fgf-2-opg-rank-and-osteocalcin-expression
#5
Lana Sarita de Souza de Oliveira, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo Júnior, Carlos Augusto Galvão Barboza, Boniek Castillo Dutra Borges, José Sandro Pereira da Silva
The aim of this study was to evaluate the effect of collagen sponge scaffold (CSS) implantation associated with low-level laser therapy (LLLT) on repairing bone defects. A single 5-mm cranial defect was surgically created in forty Wistar rats, which then received one of the following four interventions (n = 10 per group): no treatment (G0); bone defect implanted with collagen sponge scaffold (CSS) alone (G1); defect treated with low-level laser therapy (LLLT) (wavelength 780 nm; total energy density 120 J/cm(2) ; power 50 mW) alone (G2); and CSS associated with LLLT treatment (G3)...
May 29, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28543723/neuromuscular-junctions-nmjs-ultrastructural-analysis-and-nicotinic-acetylcholine-receptor-nachr-subunit-mrna-expression-in-offspring-subjected-to-protein-restriction-throughout-pregnancy
#6
Paula Aiello Tomé de Souza Castro, Ludimila Canuto Faccioni, Patrícia Aline Boer, Robson Francisco Carvalho, Selma Maria Michelin Matheus, Maeli Dal-Pai-Silva
Protein restriction during gestation can alter the skeletal muscle phenotype of offspring; however, little is known with regard to whether this also affects the neuromuscular junction (NMJ), as muscle phenotype maintenance depends upon NMJ functional integrity. This study aimed to evaluate the effects of a low protein (6%) intake by dams throughout gestation on male offspring NMJ morphology and nicotinic acetylcholine receptor (nAChR) α1, γ and ε subunit expression in the soleus (SOL) and extensor digitorum longus (EDL) muscles...
May 25, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28543963/ageing-is-associated-with-brown-adipose-tissue-remodelling-and-loss-of-white-fat-browning-in-female-c57bl-6-mice
#7
Leidyanne Ferreira Gonçalves, Thaissa Queiroz Machado, Camila Castro-Pinheiro, Nathalia Guimaraes de Souza, Karen Jesus Oliveira, Caroline Fernandes-Santos
Fat storage changes throughout life and affects body metabolism. Ageing impact on brown (BAT) and white adipose tissue (WAT) deserves attention, especially in females, because they are less prone to age-induced weight gain. While in male mice the impact of ageing on adipose tissue remodelling is well characterized, the effects in female mice remain largely unclear. Thus, we investigated BAT and WAT remodelling during ageing in female C57BL/6 mice. At 3 months, body weight was 24 ± 0.3 g (mean±SD), and it increased from 6 to 9 months of age (+20%, P < 0...
May 24, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28439920/understanding-human-thiol-dioxygenase-enzymes-structure-to-function-and-biology-to-pathology
#8
REVIEW
Bibekananda Sarkar, Mahesh Kulharia, Anil K Mantha
Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygenases: cysteine dioxygenase (CDO) and 2-aminoethanethiol dioxygenase (ADO). CDO and ADO are the only human thiol dioxygenases reported with a role in Cys metabolism and localized to mitochondria...
April 24, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28556395/effects-of-exercise-training-on-breast-cancer-metastasis-in-a-rat-model
#9
Antonieta Alvarado, Rui M Gil da Costa, Ana I Faustino-Rocha, Rita Ferreira, Carlos Lopes, Paula A Oliveira, Bruno Colaço
Exercise training is thought to play a protective role against cancer development and metastasis, either by reducing hormonal stimulation of hormone-dependent cancers or by reducing the permeability of vascular walls towards invading metastatic cells. The purpose of this work was to evaluate the role of long-term exercise training in the development and metastasis of breast cancer, in an immune-competent 1-methyl-1-nitrosourea (MNU) induced rat model. A single MNU dose was administered to Sprague-Dawley rats at 50 days of age and the rats were subjected to exercise training on a treadmill at 20 m/min, 60 min/day, 5 days/week for 35 weeks...
February 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28508516/fell-muir-lecture-collagen-fibril-formation-in-vitro-and-in-vivo
#10
REVIEW
Karl E Kadler
It is a great honour to be awarded the Fell Muir Prize for 2016 by the British Society of Matrix Biology. As recipient of the prize, I am taking the opportunity to write a minireview on collagen fibrillogenesis, which has been the focus of my research for 33 years. This is the process by which triple helical collagen molecules assemble into centimetre-long fibrils in the extracellular matrix of animals. The fibrils appeared a billion years ago at the dawn of multicellular animal life as the primary scaffold for tissue morphogenesis...
February 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28449369/exposure-to-the-insecticide-endosulfan-induces-liver-morphology-alterations-and-oxidative-stress-in-fruit-eating-bats-artibeus-lituratus
#11
Jerusa Maria Oliveira, Alessandro Brinati, Liany Divina Lima Miranda, Danielle Barbosa Morais, José Cola Zanuncio, Reggiani Vilela Gonçalves, Maria do Carmo Gouveia Peluzio, Mariella Bontempo Freitas
Exposure to pesticides may increase the generation of reactive oxygen species (ROS), leading to oxidation of cell membrane lipids and proteins. Although fruit bats are potentially exposed to pesticides during their entire lifespan, the impacts of this exposure are still poorly investigated. We examined the effects of low, commercially recommended concentrations (0, 1.05 and 2.1 g/l) of an organochlorine insecticide endosulfan (EDS) formulation on oxidative responses in the liver and kidneys of Neotropical fruit bats (Artibeus lituratus), as well as possible liver morphological alterations following a 35-day oral exposure...
February 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28444853/experimental-type-2-diabetes-induction-reduces-serum-vaspin-but-not-serum-omentin-in-wistar-rats
#12
Cynthia Aparecida de Castro, Karina Ana da Silva, Marina Molina Buffo, Karina Nogueira Zambone Pinto, Fernanda de Oliveira Duarte, Keico Okino Nonaka, Fernanda de Freitas Aníbal, Ana Cláudia Garcia de Oliveira Duarte
Vaspin and omentin are adipose tissue adipokines that have often been related to obesity and its comorbidities. The aim of this study was to investigate the behaviour of serum omentin and vaspin in models of type 2 diabetes. To do this, Wistar rats (~200 g) were randomly divided into two groups: a non-diabetic group (n = 6) and a diabetic group fed on a high-fat diet (n = 6) and a low dose of streptozotocin (Sigma(®) ). All procedures were approved by the Brazilian Ethics Committee. Body weight (BW) and food intake were recorded daily...
February 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28421649/decreased-expression-of-epha5-is-associated-with-fuhrman-nuclear-grade-and-pathological-tumour-stage-in-ccrcc
#13
Xiaolin Wang, Haifei Xu, Zhijun Wu, Xiao Chen, Jiandong Wang
The incidence of renal cell carcinoma is increasing all over the world. The molecular mechanisms for tumorigenesis, progression and prognosis are still unknown. The erythropoietin-producing hepatoma amplified sequence (Eph) receptors have been reported to be expressed aberrantly in many types of human cancers and in particular EphA5 may play a role in certain human cancers. In this study, a set of clear cell renal cell carcinoma (ccRCC) tissues were subjected to immunohistochemistry. The relationship between EphA5 protein expression and clinicopathological parameters was statistically analysed...
February 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28370591/mefenamic-acid-decreases-inflammation-but-not-joint-lesions-in-experimental-osteoarthritis
#14
Grazielle C Aguiar, Celso M Queiroz-Junior, Giovana L Sitta, Flávio A Amaral, Mauro M Teixeira, Marcelo V Caliari, Anderson J Ferreira
Mefenamic acid is a non-steroidal anti-inflammatory drug able to control the symptoms of osteoarthritis (OA), but its effects on protection of cartilage and bone are still unclear. This study aimed to investigate whether the control of inflammation by mefenamic acid translates into decreased joint lesions in experimental OA in rats. OA was induced by injecting 1 mg of monosodium iodoacetate (MIA) into the joints of rats. The animals were treated with mefenamic acid (50 mg/kg, daily, oral gavage) either pre-MIA injection (preventive) or post-MIA injection (therapeutic)...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28205343/association-of-chloride-intracellular-channel-4-and-indian-hedgehog-proteins-with-survival-of-patients-with-pancreatic-ductal-adenocarcinoma
#15
Qiong Zou, Zhulin Yang, Daiqiang Li, Ziru Liu, Yuan Yuan
Pancreatic cancer is the fourth most common cause of cancer-related mortality. Novel molecular biomarkers need to be identified for personalized medicine and to improve survival. The aim of this study was to examine chloride intracellular channel 4 (CLIC4) and Indian Hedgehog (Ihh) expression in benign and malignant lesions of the pancreas and to examine the eventual association between CLIC4 and Ihh expression, with clinicopathological features and prognosis of pancreatic cancer. A retrospective study of specimens collected from January 2000 to December 2011 at the Department of Pathology of the Second and Third Xiangya Hospitals, Central South University was undertaken to explore this question...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28205266/role-of-parnaparin-in-atherosclerosis
#16
Francesca Bonomini, Samanta Taurone, Pierpaolo Parnigotto, Loris Zamai, Luigi F Rodella, Marco Artico, Rita Rezzani
Atherosclerosis is characterized by a proliferation of vascular smooth muscle cells (VSMCs) and their migration to the intima, which induces thickening of the intima itself, but the mechanism remains poorly understood. Low molecular weight heparin (LMWH) inhibits the proliferation of VSMCs. Previous studies have shown that a LMWH, parnaparin (PNP), acts on the processes of atherogenesis and atheroprogression in experimental animal models. The aim of this study was to investigate the involvement of oxidative stress, inflammation and VSMCs in the regulation of vascular wall homeostasis...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28008677/emphysema-induced-by-elastase-enhances-acute-inflammatory-pulmonary-response-to-intraperitoneal-lps-in-rats
#17
Lídia Maria Carneiro da Fonseca, Maycon Moura Reboredo, Leda Marília Fonseca Lucinda, Thaís Fernanda Fazza, Maria Aparecida Esteves Rabelo, Adenilson Souza Fonseca, Flavia de Paoli, Bruno Valle Pinheiro
Abnormalities in lungs caused by emphysema might alter their response to sepsis and the occurrence of acute lung injury (ALI). This study compared the extension of ALI in response to intraperitoneal lipopolysaccharide (LPS) injection in Wistar rats with and without emphysema induced by elastase. Adult male Wistar rats were randomized into four groups: control, emphysema without sepsis, normal lung with sepsis and emphysema with sepsis. Sepsis was induced, and 24 h later the rats were euthanised. The following analysis was performed: blood gas measurements, bronchoalveolar lavage (BAL), lung permeability and histology...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28004436/vein-graft-disease-in-a-knockout-mouse-model-of-hyperhomocysteinaemia
#18
Christina Maria Steger, Tobias Mayr, Nikolaos Bonaros, Johannes Bonatti, Thomas Schachner
A major reason for vein graft failure after coronary artery bypass grafting is neointimal hyperplasia and thrombosis. Elevated serum levels of homocysteine (Hcy) are associated with higher incidence of cardiovascular disease, but homocysteine levels also tend to increase during the first weeks or months after cardiac surgery. To investigate this further, C57BL/6J mice (WT) and cystathionine-beta-synthase heterozygous knockout mice (CBS+/-), a mouse model for hyperhomocysteinaemia, underwent interposition of the vena cava of donor mice into the carotid artery of recipient mice...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27995666/hypermethylation-of-atp-binding-cassette-b1-abcb1-multidrug-resistance-1-mdr1-is-associated-with-cisplatin-resistance-in-the-a549-lung-adenocarcinoma-cell-line
#19
Angui Li, Jianfei Song, Qi Lai, Bangqing Liu, Haiyong Wang, Yinhui Xu, Xiaoyan Feng, Xiaolin Sun, Zhenzong Du
Development of multiple drug resistance has been attributed to the overexpression of the ATP-binding cassette B1 (ABCB1) gene. In this study, the major purpose was to assess the expression and methylation levels of ABCB1 in human lung adenocarcinoma and to reveal the relationship between these processes and acquisition of cisplatin (DDP) resistance in the human cancer cell line A549. Methylation and expression levels of the ABCB1 gene ABCB1 in clinical human lung tissue were assessed using bisulphite sequencing, reverse transcription real-time PCR (RT(2) -PCR) and Western blot methods...
December 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27925325/inflammation-oxidative-stress-and-apoptosis-cascade-implications-in-bisphenol-a-induced-liver-fibrosis-in-male-rats
#20
Sahar El-Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasan
Bisphenol A (BPA) is a key monomer in the production of plastics. It has been shown to be hepatotoxic. Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of chronic exposure to BPA on the development of hepatic fibrosis in male rats and to determine the cross-talk between the hepatic cytokine network, oxidative stress and apoptosis. For this purpose, 30 male Wistar albino rats were divided into three equal groups as follows: the first group was given no treatment (normal control group); the second group was given corn oil once daily by oral gavage for 8 weeks (vehicle control group); and the third group received BPA (50 mg/kg body weight/day, p...
October 2016: International Journal of Experimental Pathology
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