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Photodermatology, Photoimmunology & Photomedicine

Randa Youssef, Mona R E Abdel-Halim, Marwa Kamel, Mervat Khorshid, Aya Fahim
Genetics play an important role in the development of psoriasis. Moreover, inter- individual genetic differences have explained the varied response of psoriatic patients to different therapeutic modalities, and the personal variations in the development of adverse drug reactions (1) . Narrow band-UVB (Nb-UVB) offers a well-established treatment modality for psoriasis by targeting IFN-γ-producing Th1 cells, as well as several cytokines involved in the pathogenesis of psoriasis such as: interleukin 12 (IL-12), interleukin 17 (IL-17) and interleukin 23 (IL-23) (2) ...
May 15, 2018: Photodermatology, Photoimmunology & Photomedicine
O Zaar, A Sjöholm Hylén, M Gillstedt, J Paoli
BACKGROUND: Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimise the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. METHODS: In this prospective, randomised study with a split-face design, patients with, symmetrically distributed AKs were included...
May 12, 2018: Photodermatology, Photoimmunology & Photomedicine
Anke König, Svenja Missalla, Eva M Valesky, August Bernd, Roland Kaufmann, Stefan Kippenberger, Nadja N Zöller
Wound healing is a complex process which can be divided into four phases: hemostasis, inflammation, proliferation and scar-remodelling (1). Imbalance of cell proliferation, synthesis and degradation of extracellular matrix proteins can cause e.g. chronic wounds or the development of hypertrophic scars. In recent years the application of photobiomodulatory therapies has increased. Both low level light therapy (LLLT) and near infrared (NIR) have a high tissue penetration efficiency without inducing a severe surface temperature increase or pain (2)...
April 26, 2018: Photodermatology, Photoimmunology & Photomedicine
Won Jin Hong, Sang Eun Lee, Mi Ryung Roh, Jee Eun Kim, Chikako Nishigori, Soo-Chan Kim
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by photosensitivity and increased risk for developing multiple skin neoplasms. Approximately 80 percent of XP patients have a nucleotide excision repair (NER) defect leading to the defective repair of DNA damage by ultraviolet radiations (UVR). The XP variant (XP-V) subtype (OMIM no.278750) is caused by mutation in the POLH gene (OMIM *603968) which encodes polymerase (pol)eta, a member of the Y family of bypass DNA polymerases that facilitate DNA translesion synthesis...
April 23, 2018: Photodermatology, Photoimmunology & Photomedicine
Mira Han, Jung-Soo Bae, Chang-Yup Shin, Jae-Jun Ban, Qing-Ling Quan, Dong Hun Lee, Jin Ho Chung
We are exposed to sunlight that contains ultraviolet (UV) rays that are absorbed through our skin and eyes. Sunlight is responsible for the synthesis of vitamin D and maintains the balance of serotonin and melatonin (1). However, exposure to excessive sunlight causes skin cancer, and eye diseases such as UV-induced keratitis and cortical cataract. Moreover, skin exposure to UV regulates systemic homeostasis. This article is protected by copyright. All rights reserved.
April 23, 2018: Photodermatology, Photoimmunology & Photomedicine
C Backes, A Religi, L Moccozet, L Vuilleumier, D Vernez, J-L Bulliard
BACKGROUND/PURPOSE: Solar ultraviolet radiation (UVR) doses received by individuals are highly influenced by behavioural and environmental factors. This study aimed at quantifying hats' sun protection effectiveness in various exposure conditions, by predicting UVR exposure doses and their anatomical distributions. METHODS: A well-defined three-dimensional head morphology and four hat styles (a cap, a helmet, a middle- and a wide-brimmed hat) were added to a previously published model...
April 23, 2018: Photodermatology, Photoimmunology & Photomedicine
E Gellén, G B Papp, E A Janka, T Gáll, G Paragh, G Emri, B Nemes, É Remenyik
BACKGROUND: The role of sun exposure in the development of melanoma and non-melanoma skin cancers is known; however, there are limited data on the contribution of pre-transplantation total sun burden (TSB) to the increased skin cancer risk in organ transplant recipients (OTRs). The importance of patient education about sun-safe behaviours is understood, but educations are often unsuccessful in OTRs. METHODS: A questionnaire-based cross-sectional study was performed with kidney transplant patients at a single academic centre to assess the pre- and post-transplant sun-exposure, sun-protection habits and skin cancers...
March 24, 2018: Photodermatology, Photoimmunology & Photomedicine
Z Apalla, A Lallas, A Tsorova, C Nikolaidou, E Vakirlis, D Ioannides, E Sotiriou
Extramammary Paget΄s Disease (EMPD) is a rare, intraepithelial adenocarcinoma of poorly defined origin. It affects middle-aged and elderly males and females. It is usually confined to the skin, but in approximately 20% of the cases, it can be related to an occult malignancy of genitourinary or gastrointestinal system. Sites of predilection are the genital and perianal area.1 This article is protected by copyright. All rights reserved.
March 24, 2018: Photodermatology, Photoimmunology & Photomedicine
Qiuju Wu, Ping Tu, Guoyu Zhou, Huilan Yang, Zhanchao Zhou, Yi Zhao, Qingshan Zheng, Ying Gu, Jining Tao, Xuejun Zhu
BACKGROUND/PURPOSE: Previous studies have shown that hemoporfin-mediated photodynamic therapy (PDT) was a treatment for port-wine stain (PWS). Our current study aimed to identify optimal hemoporfin dose. METHODS: A prospective, multicenter, double-blind, randomized clinical trial was conducted. Patients were assigned into low- or high-dose hemoporfin (2.5 mg/kg and 5 mg/kg intravenously, respectively), or control (placebo) group, at a rate of 2:2:1. Treatment efficacy was evaluated at week 8...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Brian L Diffey, Curtis D Mobley
BACKGROUND/PURPOSE: The purpose of this paper is to estimate the contribution to our erythemal exposure at the coast of solar ultraviolet (UV) both reflected from, and transmitted into, the ocean. METHODS: The reflection of solar UV radiation from, and transmitted into, seawater was calculated using a numerical model under a number of atmospheric conditions to estimate erythemal exposure on the skin of supine/prone and ambulant people. RESULTS: The results were expressed as UV Indices...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Ann K Haylett, Dimitra Koumaki, Lesley E Rhodes
BACKGROUND: Solar urticaria (SU) is a rare chronic inducible urticaria triggered via uncharacterized chromophores. We detail responses of a large patient series to monochromator phototesting and broadband ultraviolet radiation (UVR); relationship to life quality is explored. METHODS: Retrospective review of all SU patients undergoing standardized diagnostic photoinvestigation at a specialist centre during 2000-2016. From 2011, patients completed dermatology life quality index (DLQI) questionnaires for the past week and year...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Beatrice Raone, Annalisa Patrizi, Carlotta Gurioli, Andrea Gazzola, Giulia Maria Ravaioli
BACKGROUND: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved. METHODS: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. RESULTS: In all, 375 patients were included, each receiving a mean follow-up of 6...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Matthieu Say, Alain Beauchet, Ioannis Vouldoukis, Pascale Beauchet, Monique Boudet, Emilie Tella, Emmanuel Mahé
BACKGROUND: The major risk factor for skin cancers is exposure to solar and artificial ultraviolet radiation, in particular during childhood and adolescence. In France, a law was restricted for tanning-bed access to adults (≥18 years) since 1997. OBJECTIVE: To evaluate teenagers' artificial tanning behaviour in 2016 and to compare results with those obtained in a similar survey performed in 2011. METHODS: The SOLADO 2011 and 2016 surveys were conducted in a general school in Antony and a technical school in Fontenay-aux-Roses (Paris suburb)...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
V Nikolaou, A Sachlas, E Papadavid, A Economidi, K Karambidou, L Marinos, A Stratigos, C Antoniou
BACKGROUND: Phototherapy is one of the main treatments for mycosis fungoides (MF). In this study, we analyzed the efficacy and safety of phototherapy as a first line treatment in patients with early stage disease. METHODS: We analyzed treatment outcomes in a group of 227 early stage patients. The chi-squared test, the parametric t-test and ANOVA test and the non-parametric tests of Mann-Whitney and Kruskal-Wallis were applied for data analysis. RESULTS: 55...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
Ida M Heerfordt, Linnea R Torsnes, Peter A Philipsen, Hans Christian Wulf
BACKGROUND: To be effective, sunscreens must be applied in a sufficient quantity and reapplication is recommended. No previous study has investigated whether time spent on sunscreen application is important for the achieved photoprotection. AIM: To determine whether time spent on sunscreen application is related to the amount of sunscreen used during a first and second application. METHODS: Thirty-one volunteers wearing swimwear applied sunscreen twice in a laboratory environment...
March 2018: Photodermatology, Photoimmunology & Photomedicine
Vinayak K Nahar, Meagen Rosenthal, Stephenie C Lemon, Kevin Kane, Jie Cheng, Jessica L Oleski, Wenjun Li, Joel J Hillhouse, Sherry L Pagoto
BACKGROUND/PURPOSE: Research suggests that youth proximity to tanning salons may promote use; however, little is known about tanning salon proximity to schools. We assessed the proximity of tanning salons to schools in urban versus rural/suburban communities across Worcester County, Massachusetts (population > 800K). To put findings in context, we compared school proximity to tanning salons to school proximity to McDonald's restaurants, a large franchise that also caters to young people...
March 2018: Photodermatology, Photoimmunology & Photomedicine
Vincent Richer, Pegah Kharazmi, Tim K Lee, Sunil Kalia, Harvey Lui
BACKGROUND: There is no accepted method to objectively assess the visual appearance of sunscreens on the skin. METHODS: We present a method for sunscreen application, digital photography, and computer analysis to quantify the appearance of the skin after sunscreen application. Four sunscreen lotions were applied randomly at densities of 0.5, 1.0, 1.5, and 2.0 mg/cm2 to areas of the back of 29 subjects. Each application site had a matched contralateral control area...
March 2018: Photodermatology, Photoimmunology & Photomedicine
Hee Jin Song, Si Hyub Lee, Gwang Seong Choi, Jeonghyun Shin
BACKGROUND: Human melanocytes express Toll-like receptor 4 (TLR4), which regulates ultraviolet (UV)-induced cutaneous immunosuppression in Langerhans cells. Lipopolysaccharide (LPS) stimulation increases melanocyte pigmentation and TLR4 expression, while inducing local innate inflammatory responses. AIMS: We investigated whether UV radiation induces TLR4 expression in neonatal human melanocytes (NHMs) and how this affects the immune system. METHODS: We cultured NHMs with LPS treatment or with one-time or repeated UVA or UVB exposure, and investigated and compared the effects on TLR4 expression, melanin contents, and cytokine production...
March 2018: Photodermatology, Photoimmunology & Photomedicine
VijayKumar Patra, Gerlinde Mayer, Alexandra Gruber-Wackernagel, Michael Horn, Serena Lembo, Peter Wolf
BACKGROUND: Polymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis. METHODS: Antimicrobial peptide profiling was carried out in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6), and psoriatic skin (n,6)...
March 2018: Photodermatology, Photoimmunology & Photomedicine
Magdalena de Troya-Martín, María Victoria de Gálvez-Aranda, Francisco Rivas-Ruiz, Nuria Blázquez-Sánchez, Maria Teresa Fernández-Morano, Laura Padilla-España, Enrique Herrera-Ceballos
BACKGROUND: Painful sunburns at any age are one of the main risk factors for skin cancer. OBJECTIVES: To determine the prevalence and predictors of sunburn among beachgoers. METHODS: A cross-sectional health survey was conducted at the beach during the summer. Adults >18 years with an understanding of Spanish were interviewed using a questionnaire about behaviours, attitudes and knowledge related to sun exposure at the beach. A descriptive analysis was performed, and a log-binomial regression model was used to determine predictors of sunburn...
March 2018: Photodermatology, Photoimmunology & Photomedicine
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