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Photodermatology, Photoimmunology & Photomedicine

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https://www.readbyqxmd.com/read/29419896/comparison-of-effectiveness-and-safety-of-excimer-lamp-versus-topical-calcipotriol-clobetasol-propionate-combination-in-the-treatment-of-palmoplantar-psoriasis
#1
Abhishek Thakur, Anuradha Bishnoi, Sunil Dogra, Tarun Narang
BACKGROUND: Very few studies have assessed the efficacy of excimer treatment in palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol combination. PURPOSE: To compare the effectiveness and safety of excimer lamp versus topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0.05% w/w) combination in PPP. METHODS: This right-left randomization trial included 36 patients with PPP, who received treatment with excimer lamp (twice weekly) on one side and calcipotriol-clobetasol combination once daily on another side for 12 weeks, followed by 8 weeks follow-up...
February 8, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29381828/influence-of-visible-light-on-cutaneous-hyperchromias-clinical-efficacy-of-broad-spectrum-sunscreens
#2
Ana Paula Martins Martini, Patricia Maria Berardo Gonçalves Maia Campos
INTRODUCTION: Cutaneous hyperchromias are disorders of skin pigmentation involving increased melanin production and its irregular accumulation in skin cells. The use of sunscreens is fundamental for the control of hyperchromias by reducing the stimulation of pigmentation, since melanin synthesis is mainly stimulated by solar radiation. Many studies have demonstrated that visible light can induce significant skin damage. Considering the effects of visible light, effective photoprotection should not be limited only to UV protection but should also involve visible and infrared protection...
January 30, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29352492/variability-of-pulsed-energy-outputs-from-three-dermatology-lasers-during-multiple-simulated-treatments
#3
J Britton
BACKGROUND: Dermatology laser treatments are undertaken at regional departments using lasers of different powers and wavelengths. In order to achieve good outcomes there need to be good consistency of laser output across different weeks as it is custom and practice to break down the treatments into individual fractions. Departments will also collect information from test patches to help decide on the most appropriate treatment parameters for individual patients. OBJECTIVES: The objective of these experiments is to assess the variability of the energy outputs from a small number of lasers across multiple weeks at realistic parameters...
January 20, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29235191/the-effect-of-cyanidin-3-o-glucoside-on-uva-induced-damage-in-human-dermal-fibroblasts
#4
Shi Wu, Yunfeng Hu, Zhen Li, Weibin Bai, Jiayi Zhao, Cuiqin Huang, Qin Li, Chongzhu Fan, Liehua Deng, Daxiang Lu
BACKGROUND/PURPOSE: Ultraviolet-A (UVA) radiation can induce photoaging and skin cancer, but means to prevent or treat UVA-induced skin damage require further study. We investigated the effects of cyanidin-3-o-glucoside (C3G), a monomer of anthocyanin, on UVA-induced damage in primary human dermal fibroblasts (HDFs), and we identify possible mechanisms underlying the protective effects of this compound. METHODS: Primary HDFs were pretreated with 80 μmol/L C3G for 2 hours and UVA irradiated at 12 J/cm2 ...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29235163/ultraviolet-b-eye-irradiation-aggravates-atopic-dermatitis-via-acth-and-nlrp3-inflammasome-in-nc-nga-mice
#5
Keiichi Hiramoto, Yurika Yamate, Satoshi Yokoyama
BACKGROUND: Ultraviolet (UV) B irradiation has been shown to improve atopic dermatitis (AD). However, the relationship between UVB eye irradiation and AD is not known. This issue was addressed using a mouse model of AD. METHODS: The eyes of NC/Nga mice were irradiated with UVB at a dose of 1.0 kJ/m2 using a 20SE sunlamp for the duration of the experimental period. RESULTS: AD symptoms deteriorated upon UVB eye irradiation. The levels of adrenocorticotropic hormone (ACTH) in the plasma and nucleotide-binding domain and leucine-rich-containing family, pyrin domain-containing (NLRP)3 and neutrophil markers in the skin were increased in UVB-irradiated mice...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29235160/photoprotection-by-sunscreen-depends-on-time-spent-on-application
#6
Ida M Heerfordt, Linnea R Torsnes, Peter A Philipsen, Hans Christian Wulf
BACKGROUND: To be effective, sunscreens must be applied in a sufficient quantity and reapplication is recommended. No previous study has investigated whether time spent on sunscreen application is important for the achieved photoprotection. AIM: To determine whether time spent on sunscreen application is related to the amount of sunscreen used during a first and second application. METHODS: Thirty-one volunteers wearing swimwear applied sunscreen twice in a laboratory environment...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29223131/photodynamic-therapy-in-the-treatment-of-symptomatic-oral-lichen-planus-a-systematic-review
#7
REVIEW
Zohaib Akram, Fawad Javed, Mervyn Hosein, Mohammed Ayedh Al-Qahtani, Fayez Alshehri, Ahmed Ibrahim Alzahrani, Fahim Vohra
BACKGROUND: The aim of this systematic review was to assess the efficacy of photodynamic therapy (PDT) in the treatment of symptomatic oral lichen planus (OLP). METHODS: This systematic review aimed to address the following focused question: "Is PDT effective in the treatment of symptomatic OLP?" Indexed databases; MEDLINE, EMBASE and CENTRAL were searched up to and including August 2017. RESULTS: Six clinical studies were included. The risk of bias was considered high in five studies and moderate in one study...
December 9, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29171925/clinical-and-photobiological-response-in-eight-patients-with-solar-urticaria-under-treatment-with-omalizumab-and-review-of-the-literature
#8
Daniel Morgado-Carrasco, Xavier Fustà-Novell, Sebastian Podlipnik, Andrea Combalia, Paula Aguilera
BACKGROUND: Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging, and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response. MATERIALS/METHODS: Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity Score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue Scale (VAS)...
November 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29314395/editorial
#9
EDITORIAL
Farrukh Afaq, Craig A Elmets
No abstract text is available yet for this article.
January 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29150967/drug-delivery-strategies-for-chemoprevention-of-uvb-induced-skin-cancer-a-review
#10
REVIEW
Arvind Bagde, Arindam Mondal, Mandip Singh
Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast, and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed toward improvements in terms of delivery modes, therapeutic agents, and site-specificity of therapeutics delivery...
January 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29044724/tea-polyphenols-for-the-prevention-of-uvb-induced-skin-cancer
#11
REVIEW
Pooja Sharma, Mary K Montes de Oca, Amena R Alkeswani, Sarah F McClees, Tanushree Das, Craig A Elmets, Farrukh Afaq
Skin cancer is the most common type of cancer with increasing incidence rate and public health burden. Solar ultraviolet (UV) radiation causes an array of damaging cellular and molecular events that eventually lead to the development of skin cancer. Despite increased awareness about sun protection, the exposure rate remains high with less than 15% of men and 30% of women using sunscreen on a regular basis. Therefore, there is an imperative need for the development of novel preventive approaches. Skin cancer chemoprevention using phytochemicals either as dietary supplements or by topical applications has gained considerable attention due to their low toxicity, availability, and anticarcinogenic properties...
January 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28681504/melanoma-and-nonmelanoma-skin-cancer-chemoprevention-a%C3%A2-role-for-nicotinamide
#12
REVIEW
Rashi Minocha, Diona L Damian, Gary M Halliday
Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR, and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and nonmelanoma skin cancers in high-risk individuals and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations...
January 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29150968/effects-of-blue-light-on-inflammation-and-skin-barrier-recovery-following-acute-perturbation-pilot-study-results-in-healthy-human-subjects
#13
Denise Falcone, Natallia E Uzunbajakava, Frank van Abeelen, Gerrit Oversluizen, Malou Peppelman, Piet E J van Erp, Peter C M van de Kerkhof
BACKGROUND/PURPOSE: While growing evidence supports the therapeutic effect of 453 nm blue light in chronic inflammatory skin diseases, data on its effects on acutely perturbed human skin are scarce. In this study, we investigated the impact of 453 nm narrow-band LED light on healthy skin following acute perturbation. METHODS: Tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers on 2 consecutive weeks. In 1 week, challenges were followed by irradiation for 30 minutes...
November 18, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29140594/cord-blood-platelet-gel-alone-or-in-combination-with-photobiomodulation-therapy-for-the-treatment-of-oral-ulcerations-in-patients-with-epidermolysis-bullosa-a-pilot-clinical-comparative-study
#14
LETTER
Ezio Sindici, Beatrice Giuliano, Simona Astesano, Luigina Fazio, Antonella Dragonetti, Mariateresa Pugliese, Stefano Carossa, Roberto Broccoletti, Paolo G Arduino
Epidermolysis bullosa (EB) is a rare group of genetically heterogeneous diseases, characterized by deficiencies in the synthesis of proteins involved in the adhesion of the connective tissue to the epithelium; the oral cavity is frequently involved but, although oral bullae, ulcers, and erosions are common, there are few published data about possible treatment (1). This article is protected by copyright. All rights reserved.
November 15, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29171149/abstracts
#15
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080373/youth-access-to-indoor-tanning-salons-in-urban-versus-rural-suburban%C3%A2-communities
#16
Vinayak K Nahar, Meagen Rosenthal, Stephenie C Lemon, Kevin Kane, Jie Cheng, Jessica L Oleski, Wenjun Li, Joel J Hillhouse, Sherry L Pagoto
Research suggests that youth proximity to tanning salons may promote use, however little is known about tanning salon proximity to schools. We assessed the proximity of tanning salons to schools in urban versus rural/suburban communities across Worcester County, Massachusetts (population > 800K). To put findings in context, we compared school proximity to tanning salons to school proximity to McDonald's restaurants, a large franchise that also caters to young people. Accessibility was measured by ArcGIS 10...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080365/narrow-band-uvb-effects-on-cutaneous-vitamin-d-receptor-expression-and-serum-25-hydroxyvitamin-d-in-generalized-vitiligo
#17
Hala M El-Hanbuli, Noha M Dawoud, Rania H Mahmoud
BACKGROUND/PURPOSE: Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. METHODS: Using immunohistochemistry, VDR expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and nonresponding skin after 24 NB-UVB sessions...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080361/narrow-band-ultraviolet-b-phototherapy-outcomes-in-atopic-dermatitis-a-single-centre-retrospective-review
#18
LETTER
J Clowry, K Molloy, L Nestor, K Edwards, A Salim, M Connolly, Anne-Marie Tobin
Systemic and biological therapies are evolving treatment modalities in the management of atopic dermatitis (AD). Despite these welcome advances in the management of refractory cases, phototherapy remains the recommended(1) second-line treatment option for AD when topical treatments fail to control symptoms. According to a recently published survey of UK dermatologists(2) , 46% of dermatologists still choose phototherapy, either narrow-band ultraviolet B (NB UVB) or psoralen ultraviolet A (PUVA) ahead of systemic therapy which is favoured by 36%...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080360/quantifying-the-visual-appearance-of-sunscreens-applied-to-the-skin-using-indirect-computer-image-colorimetry
#19
Vincent Richer, Pegah Kharazmi, Tim Lee, Sunil Kalia, Harvey Lui
BACKGROUND: There is no accepted method to objectively assess the visual appearance of sunscreens on the skin. METHODS: We present a method for sunscreen application, digital photography, and computer analysis to quantify the appearance of the skin after sunscreen application. Four sunscreen lotions were applied randomly at densities of 0.5, 1.0, 1.5 and 2.0 mg/cm(2) to areas of the back of 29 subjects. Each application site had a matched contralateral control area...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080357/src-kinase-mediates-uv-induced-trpv1-trafficking-into-cell-membrane-in-hacat-keratinocytes
#20
LETTER
Sangbum Han, So Min Kang, Jang-Hee Oh, Dong Hun Lee, Jin Ho Chung
The skin is constantly exposed to harmful external stimuli such as pathogen, particulate matter, and sunlight. Solar radiation consists of various types of rays, among which ultraviolet (UV), visible light, and infrared can reach the earth and thereby affect human skin (1). Especially, UV has several detrimental effects on the skin including cutaneous cancer, inflammation, and photoaging (2). When skin cells are exposed to UV, it causes nuclear factor kappa B (NF-kB) signaling pathway leading to the increases of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-8 (3)...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
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