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Photodermatology, Photoimmunology & Photomedicine

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https://www.readbyqxmd.com/read/28419574/phototherapy-and-photochemotherapy-for-polymorphic-light-eruption-desensitisation-a-five-year-case-series-review-from-a-university-teaching-hospital
#1
LETTER
A Aslam, L Fullerton, S H Ibbotson
Polymorphic light eruption (PLE) is the most common immunological photodermatosis, with a prevalence of 18% in Europe(1) . The pathogenesis of PLE appears to involve delayed cell mediated hypersensitivity and aberrant Langerhans cell function(2,3) . Phototherapy, using narrowband UVB (UVB) or psoralen-ultraviolet A (PUVA) photochemotherapy, is widely used for prophylactic desensitisation in PLE, with benefit experienced in 90% of patients(4,5) . This article is protected by copyright. All rights reserved.
April 17, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28370395/fixed-sunlight-eruption-a-new-idiopathic-photodermatosis-rather-than-a-variant-of-fixed-drug-eruption
#2
LETTER
Denise Gamé, Juli Bassas, Cristina Grau, Carlos Ferrándiz, José Manuel Carrascosa
Fixed eruptions are a group of inflammatory dermatoses characterized by recurrent episodes of lesions affecting the same site or sites on exposure to a trigger; most are caused by drugs (fixed drug eruption) but foods can also cause this type of reaction (fixed food eruption)(1) . With only a few cases described, fixed sunlight eruption (FSE), characterized primarily by skin lesions that recur at the same anatomic sites upon repeated exposures to sunlight, has been considered to be another variant of these fixed eruptions, with the implication that a drug or food must be involved(2-7) ...
March 31, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28370729/are-very-high-cumulative-doses-of-narrowband-uvb-safe-in-vitiligo
#3
LETTER
Sophie Momen, Robert Sarkany
The management of vitiligo poses unique challenges due to the lack of effective treatments and the devastating impact of vitiligo, especially in dark-skinned patients. Treatment response is slow, and the risk of relapse after successful treatment is high. Patients may require multiple courses of Narrowband UVB (NBUVB), resulting in very high cumulative doses of UVB1. Using data from animal studies NBUVB is considered to be a safer than PUVA(2) . This article is protected by copyright. All rights reserved.
March 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28317179/fenofibrate-induced-photosensitivity-a-case-series-and-literature-review
#4
LETTER
Kai-Chi Tsai, Jen-Hung Yang, Sung-Jen Hung
Fenofibrate, a fibric acid derivative, is among the most commonly used antihyperlipidemic medications. The most common side effects are gastrointestinal problems, including abdominal discomfort, diarrhea, and constipation. While cutaneous eruption occurred in 2% of fenofibrate users(1) , photosensitivity is a rare manifestation. Jeanmougin et al. presented the first case of fenofibrate induced photosensitivity in 1983.(2) Herein we report 4 cases of fenofibrate-induced photosensitization with different types of cutaneous eruptions as papulovesicular, lichenoid, and sunburn-like rashes, and one among them was confirmed by photopatch testing...
March 20, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28258587/pirfenidone-induced-photo-allergic-reaction-in-a-patient-with-idiopathic-pulmonary-fibrosis
#5
LETTER
Min-Young Park, Woo-Haing Shim, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
No abstract text is available yet for this article.
March 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28199748/daylight-photodynamic-therapy-with-methylene-blue-in-plane-warts-a-randomized-double-blind-placebo-controlled-study
#6
G Fathy, M K Asaad, H M Rashid
Photodynamic therapy (PDT) is a technique that utilizes reactive oxygen species produced by a non-toxic dye or photosensitizer molecule in the presence of low intensity visible light to kill mammalian or microbial cells ((1)) . The advantages of PDT are numerous, it is a safe, non-invasive technique which yields effective therapeutic results ((2)) . Photodynamic therapy is not free of adverse effects. The most common one is pain during illumination. With the use of portable light sources to optimize the procedure and facilitate outpatient treatment, the concept of ambulatory PDT has emerged...
February 15, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28196286/psoralen-with-ultraviolet-a-induced-apoptosis-of-cutaneous-lymphoma-cell-lines-is-augmented-by-type-i-interferons-via-the-jak1-stat1-pathway
#7
Walter Liszewski, David Gram Naym, Edyta Biskup, Robert Gniadecki
BACKGROUND: Photochemotherapy with psoralen and ultraviolet A (PUVA), with or without adjuvant interferon-α (IFN-α), is a first-line therapy for early-stage mycosis fungoides and other forms of cutaneous T-cell lymphoma (CTCL). However, the mechanism by which PUVA with IFN-α work in CTCL is poorly understood. PURPOSE: To develop a model to investigate the mechanisms of PUVA and PUVA with IFN-α in CTCL cells. METHODS: An in vitro model to study the molecular mechanisms of PUVA was created using two different CTCL cell lines, MyLa, which has functional p53, and HuT-78, in which p53 is inactivated due to a homozygous nonsense mutation...
February 14, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28196277/factors-predicting-pain-and-effect-of-oral-analgesia-in-topical-photodynamic-therapy
#8
LETTER
R Hambly, N Mansoor, C Quinlan, Z Shah, P Lenane, N Ralph, F J Moloney
Topical photodynamic therapy (PDT) is highly efficacious for the treatment of actinic keratosis (AK), Bowen's disease (BD) and superficial basal cell carcinoma (sBCC), and efficacious in thin nodular BCCs (nBCC).(1) It is generally well tolerated, with pain or discomfort being a known side-effect.(1) Pain is typically described as a burning or stinging sensation of varying intensity. This article is protected by copyright. All rights reserved.
February 14, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28168735/does-imiquimod-pretreatment-optimize-308-nm-excimer-laser-uvb-therapy-in-psoriasis-patients
#9
Joselin D Tacastacas, Patricia Oyetakin-White, David C Soler, Andrew Young, Sarah Groft, Kord Honda, Kevin D Cooper, Thomas S McCormick
BACKGROUND/PURPOSE: Psoriasis continues to be a debilitating skin disease affecting 1-3% of the United States population. Although the effectiveness of several current biologic therapies have described this pathology as a IL-23, TNF-a and Th17-mediated disease, less invasive approaches are still in use and in need of refinement. One of these is the usage of narrow band-UVB (NB-UVB) therapy to deplete specifically intra-epidermal CD3+, CD4+ and CD8+ cells to clear psoriatic plaques. AIMS/OBJECTIVES: In order to improve NB-UVB therapy, we sought to determine whether skin pre-treatment with the TLR7 agonist imiquimod (IMQ) would help increase the efficiency of the former at resolving psoriatic plaques...
February 7, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28165636/prevention-of-dna-damage-in-human-skin-by-topical-sunscreens
#10
Catherine M Olsen, Louise F Wilson, Adèle C Green, Neela Biswas, Juhi Loyalka, David C Whiteman
BACKGROUND/PURPOSE: There is strong evidence that topical sunscreens, designed to protect against ultraviolet radiation (UVR)-induced erythema, decrease the amount of UVR to which the skin is exposed, but their effectiveness in reducing UVR-induced DNA damage in vivo has not been well quantified. METHODS: We systematically reviewed the published literature (1990-2015) to determine whether sunscreens prevent DNA damage in human skin when applied prior to UVR exposure...
February 6, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28160768/solar-urticaria-with-a-wide-action-spectrum-from-uvb-to-visible-light-complicated-with-uva-induced-polymorphous-light-eruption
#11
LETTER
Izumi Kishimoto, Naoko Uetsu, Hirotsugu Tanimura, Hidetaka Fujii, Hiroyuki Okamoto
Solar urticaria and polymorphous light eruption (PLE) are acquired idiopathic photosensitivity disorders, but each phenomenon is extremely different; one is an immediate reaction, and one is a delayed-type reaction. Phototesting is necessary not only for the diagnosis of these photosensitivity disorders but also for the determination of the action spectrum so that the patient can try to avoid the triggering wavelengths in ordinary life. Solar urticaria is unique in that the particular spectra that inhibit or enhance the reactions by action spectra are present in some cases...
February 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28140474/protective-effects-of-polypodium-leucotomos-extract-against-uvb-induced-damage-in-a-model-of-reconstructed-human-epidermis
#12
Paola Torricelli, Milena Fini, Pier Alessandro Fanti, Emi Dika, Massimo Milani
Polypodium leucotomos (PL) exerts potent antioxidant, photo-protective and immune-modulatory activities. A reconstructed human epidermis (RHE) (Episkin) is a suitable model for the evaluation of acute UV-induced cell damage. No data regarding the photo-protective action of PL in this model are available. We evaluated the effects of PL on the prevention of UVB-induced cell damage assessing sunburn cells, CPD formation, p53, Ki-67, p21 expression, and Epidermal Growth Factor (EGF) production. RHE was incubated in standard conditions...
January 31, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28130797/influence-of-demographic-and-clinical-characteristics-of-actinic-keratosis-patients-on-illness-perceptions-and-readiness-to-increase-sun-protection-behaviours-an-exploratory-study
#13
Sevgi Akarsu, Ozlem Ozbagcivan, Turna Ilknur, Fatma Semiz, Emel Fetil
BACKGROUND/PURPOSE: There are no data comprehensively investigating the key beliefs and sun-protection behaviours in patients with actinic keratosis (AK). Our aim is to determine and correlate the AK perceptions and readiness to increase sun protection (RISP) behaviours. METHODS: AK patients' (n=200) demographics and clinical findings were recorded. Participants completed questionnaires (Illness Perception Questionnaire-Revised and RISP behaviours scales). RESULTS: The mean scores of giving up sunbathing of the patients aged <65 years, and giving up sunbathing and staying in the shade behaviours of females were higher...
January 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28130791/photodynamic-therapy-for-dermatologic-conditions-in-the-pediatric-population-a-literature-review
#14
REVIEW
Neha Kumar, Christine B Warren
BACKGROUND: Photodynamic therapy (PDT), using topical aminolevulinic acid (ALA), has been used for years to treat a variety of dermatologic conditions, including actinic keratosis, superficial basal cell carcinoma, and in situ squamous cell carcinoma. While there is a wide range of neoplastic and non-neoplastic skin diseases for which ALA-PDT is used in adults, there is a knowledge gap when it comes to its use in children. This review highlights what is currently known regarding the use and efficacy of this therapy in the pediatric population...
January 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28106292/23-hydroxytormentic-acid-protects-human-dermal-fibroblasts-by-attenuating-uva-induced-oxidative-stress
#15
Hae Jeong Youn, Ki Bbeum Kim, Hyo-Sun Han, In-Sook An, Kyu Joong Ahn
BACKGROUND: Ultraviolet A (UVA), one of the major components of sunlight, can penetrate the dermal layer of the skin and generate reactive oxygen species (ROS). It causes alterations in the dermal connective tissue and gene expression, inflammation, photoaging, and DNA damage. AIMS: Therefore, the harmful effects of UVA and strategies to reduce it have been consistently investigated. 23-Hydroxytormentic acid (23-HTA) has been demonstrated to improve drug-induced nephrotoxicity and exhibit several free radical scavenging effects with other molecules...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28039945/the-tanning-habits-and-interest-in-sunscreen-of-google-users-what-happened-in-12-years
#16
Michael C Kirchberger, Markus V Heppt, Thomas K Eigentler, Markus A Kirchberger, Gerold Schuler, Lucie Heinzerling
BACKGROUND: The incidence of melanoma has been rising worldwide. One possible reason for this is natural and artificial UV exposure. Only little data on actual consumer statistics from tanning studios and the usage of sunscreen are available. Therefore, it is difficult to describe trends for both and identify the impact of preventive measures. METHODS: To gain knowledge about the popularity of 'tanning bed' and 'sunscreen', normalized search volumes for both search queries were obtained from Google Trends for 11 countries between January 2004 and June 2016...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28039905/ultraviolet-a-eye-irradiation-ameliorates-colon-carcinoma-induced-by-azoxymethane-and-dextran-sodium-sulfate-through-%C3%AE-endorphin-and-methionine-enkephalin
#17
Keiichi Hiramoto, Satoshi Yokoyama, Yurika Yamate
BACKGROUND: We previously reported that ultraviolet (UV) A eye irradiation reduces the ulcerative colitis induced by dextran sodium sulfate (DSS). This study examined the effects of UVA on colon carcinoma induced by azoxymethane (AOM) and DSS. METHODS: We irradiated the eyes of ICR mice with UVA at a dose of 110 kJ/m(2) using an FL20SBLB-A lamp for the experimental period. RESULTS: In mice treated with these drugs, the symptom of colon carcinoma was reduced by UVA eye irradiation...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27995657/protective-effects-of-aloe-sterols-against-uvb-induced-photoaging-in-hairless-mice
#18
Eriko Misawa, Miyuki Tanaka, Marie Saito, Kazumi Nabeshima, Ruiqing Yao, Kouji Yamauchi, Fumiaki Abe, Yuki Yamamoto, Fukumi Furukawa
BACKGROUND: Aloe vera is a traditional medical plant whose gel has been widely used in skin care. Previously, we have identified Aloe sterols from Aloe vera as active ingredients. This study investigated the protective effects of Aloe sterols without polysaccharides, against ultraviolet B (UVB)-induced skin photoaging in mice using Aloe vera gel extract (AVGE) obtained by supercritical fluid extraction. METHODS: Aloe vera gel extract was supplemented in the diet (12 or 120 ppm), and HR-1 hairless mice were exposed to UVB irradiation for 7 weeks...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27995652/correlates-of-sun-protection-behaviors-among-hispanic-children-residing-in-a-high-uvr-environment
#19
Kimberly A Miller, Jimi Huh, Jennifer B Unger, Jean L Richardson, Martin W Allen, David H Peng, Myles G Cockburn
BACKGROUND/PURPOSE: Rates of melanoma are rising in Hispanics in the United States. Excessive sun exposure in childhood increases the risk of melanoma in adulthood, and little is known about the factors motivating sun protection behaviors among Hispanic youth. METHODS: Correlates of sun protection were examined among Hispanic children residing in Los Angeles, California (N = 1891). Associations between multiple constructs (psychosocial, familial, and cultural) and sun protection outcomes (use of sunscreen, protective clothing, and shade seeking/sun avoidance) were examined...
March 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27982466/expansion-of-the-genotypic-and-phenotypic-spectrum-of-xeroderma-pigmentosum-in-chinese-population
#20
Jia Zhang, Ruhong Cheng, Xia Yu, Zhonghui Sun, Ming Li, Zhirong Yao
BACKGROUND: Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by exaggerated sunburn reactions, freckle-like pigmentation, and a high possibility of developing cutaneous tumors. XP comprised seven complementation groups (from XP-A to XP-G) and a variant form XP-V. METHODS: This study was based on five unrelated Chinese families with six patients clinically suspected to be XP. Mutation screening was performed by direct sequencing of the entire coding region of eight XP genes...
January 2017: Photodermatology, Photoimmunology & Photomedicine
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