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Photodermatology, Photoimmunology & Photomedicine

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https://www.readbyqxmd.com/read/29223131/photodynamic-therapy-in-the-treatment-of-symptomatic-oral-lichen-planus-a-systematic-review
#1
REVIEW
Zohaib Akram, Fawad Javed, Mervyn Hosein, Mohammed Ayedh Al-Qahtani, Fayez Alshehri, Ahmed Ibrahim Alzahrani, Fahim Vohra
BACKGROUND: The aim of this systematic review was to assess the efficacy of photodynamic therapy (PDT) in the treatment of symptomatic oral lichen planus (OLP). METHODS: This systematic review aimed to address the following focused question: "Is PDT effective in the treatment of symptomatic OLP?" Indexed databases; MEDLINE, EMBASE and CENTRAL were searched up to and including August 2017. RESULTS: Six clinical studies were included. The risk of bias was considered high in five studies and moderate in one study...
December 9, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29171925/clinical-and-photobiological-response-in-eight-patients-with-solar-urticaria-under-treatment-with-omalizumab-and-review-of-the-literature
#2
D Morgado-Carrasco, X Fustà-Novell, S Podlipnik, A Combalia, P Aguilera
BACKGROUND: Solar urticaria (SU) is a rare photodermatosis. Treatment is challenging and outcomes are often disappointing. Omalizumab is an anti-IgE, currently approved for treatment of chronic spontaneous urticaria. We sought to evaluate therapy with omalizumab in refractory SU and describe predictive factors for response. MATERIALS/METHODS: Patients with refractory SU under treatment with omalizumab were included in this study. Clinical outcome was evaluated using the Urticaria Activity score 7 (UAS7), Dermatology Life Quality Index (DLQI) and Pruritus Visual Analogue scale (VAS)...
November 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29150968/effects-of-blue-light-on-inflammation-and-skin-barrier-recovery-following-acute-perturbation-pilot-study-results-in-healthy-human-subjects
#3
Denise Falcone, Natallia E Uzunbajakava, Frank van Abeelen, Gerrit Oversluizen, Malou Peppelman, Piet E J van Erp, Peter C M van de Kerkhof
BACKGROUND/PURPOSE: While growing evidence supports the therapeutic effect of 453 nm blue light in chronic inflammatory skin diseases, data on its effects on acutely-perturbed human skin are scarce. In this study we investigated the impact of 453 nm narrow-band LED light on healthy skin following acute perturbation. METHODS: Tape stripping and histamine iontophoresis were performed on the forearm of 22 healthy volunteers on two consecutive weeks. In one week, challenges were followed by irradiation for 30 minutes...
November 18, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29150967/drug-delivery-strategies-for-chemoprevention-of-uvb%C3%A2-induced-skin-cancer-a-review
#4
REVIEW
Arvind Bagde, Arindam Mondal, Mandip Singh
Annually, more skin cancer cases are diagnosed than the collective incidence of the colon, lung, breast and prostate cancer. Persistent contact with sunlight is a primary cause for all the skin malignancies. UVB radiation induces reactive oxygen species (ROS) production in the skin which eventually leads to DNA damage and mutation. Various delivery approaches for the skin cancer treatment/prevention have been evolving and are directed towards improvements in terms of delivery modes, therapeutic agents and site-specificity of therapeutics delivery...
November 18, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29140594/cord-blood-platelet-gel-alone-or-in-combination-with-photobiomodulation-therapy-for-the-treatment-of-oral-ulcerations-in-patients-with-epidermolysis-bullosa-a-pilot-clinical-comparative-study
#5
LETTER
Ezio Sindici, Beatrice Giuliano, Simona Astesano, Luigina Fazio, Antonella Dragonetti, Mariateresa Pugliese, Stefano Carossa, Roberto Broccoletti, Paolo G Arduino
Epidermolysis bullosa (EB) is a rare group of genetically heterogeneous diseases, characterized by deficiencies in the synthesis of proteins involved in the adhesion of the connective tissue to the epithelium; the oral cavity is frequently involved but, although oral bullae, ulcers, and erosions are common, there are few published data about possible treatment (1). This article is protected by copyright. All rights reserved.
November 15, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080373/youth-access-to-indoor-tanning-salons-in-urban-versus-rural-suburban%C3%A2-communities
#6
Vinayak K Nahar, Meagen Rosenthal, Stephenie C Lemon, Kevin Kane, Jie Cheng, Jessica L Oleski, Wenjun Li, Joel J Hillhouse, Sherry L Pagoto
Research suggests that youth proximity to tanning salons may promote use, however little is known about tanning salon proximity to schools. We assessed the proximity of tanning salons to schools in urban versus rural/suburban communities across Worcester County, Massachusetts (population > 800K). To put findings in context, we compared school proximity to tanning salons to school proximity to McDonald's restaurants, a large franchise that also caters to young people. Accessibility was measured by ArcGIS 10...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080365/narrow-band-uvb-effects-on-cutaneous-vitamin-d-receptor-expression-and-serum-25-hydroxyvitamin-d-in-generalized-vitiligo
#7
Hala M El-Hanbuli, Noha M Dawoud, Rania H Mahmoud
BACKGROUND/PURPOSE: Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow-band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor.This study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. METHODS: Using immunohistochemistry, VDR expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and nonresponding skin after 24 NB-UVB sessions...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080361/narrow-band-ultraviolet-b-phototherapy-outcomes-in-atopic-dermatitis-a-single-centre-retrospective-review
#8
LETTER
J Clowry, K Molloy, L Nestor, K Edwards, A Salim, M Connolly, Anne-Marie Tobin
Systemic and biological therapies are evolving treatment modalities in the management of atopic dermatitis (AD). Despite these welcome advances in the management of refractory cases, phototherapy remains the recommended(1) second-line treatment option for AD when topical treatments fail to control symptoms. According to a recently published survey of UK dermatologists(2) , 46% of dermatologists still choose phototherapy, either narrow-band ultraviolet B (NB UVB) or psoralen ultraviolet A (PUVA) ahead of systemic therapy which is favoured by 36%...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080360/quantifying-the-visual-appearance-of-sunscreens-applied-to-the-skin-using-indirect-computer-image-colorimetry
#9
Vincent Richer, Pegah Kharazmi, Tim Lee, Sunil Kalia, Harvey Lui
BACKGROUND: There is no accepted method to objectively assess the visual appearance of sunscreens on the skin. METHODS: We present a method for sunscreen application, digital photography, and computer analysis to quantify the appearance of the skin after sunscreen application. Four sunscreen lotions were applied randomly at densities of 0.5, 1.0, 1.5 and 2.0 mg/cm(2) to areas of the back of 29 subjects. Each application site had a matched contralateral control area...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29080357/src-kinase-mediates-uv-induced-trpv1-trafficking-into-cell-membrane-in-hacat-keratinocytes
#10
LETTER
Sangbum Han, So Min Kang, Jang-Hee Oh, Dong Hun Lee, Jin Ho Chung
The skin is constantly exposed to harmful external stimuli such as pathogen, particulate matter, and sunlight. Solar radiation consists of various types of rays, among which ultraviolet (UV), visible light, and infrared can reach the earth and thereby affect human skin (1). Especially, UV has several detrimental effects on the skin including cutaneous cancer, inflammation, and photoaging (2). When skin cells are exposed to UV, it causes nuclear factor kappa B (NF-kB) signaling pathway leading to the increases of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, and IL-8 (3)...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29063638/repeated-ultraviolet-irradiation-induces-the-expression-of-toll-like-receptor-4-il-6-and-il-10-in-neonatal-human-melanocytes
#11
Hee Jin Song, Si Hyub Lee, Gwang Seong Choi, Jeonghyun Shin
BACKGROUND: Human melanocytes express Toll-like receptor 4 (TLR4), which regulates ultraviolet (UV)-induced cutaneous immunosuppression in Langerhans cells. Lipopolysaccharide (LPS) stimulation increases melanocyte pigmentation and TLR4 expression, while inducing local innate inflammatory responses. AIMS: We investigated whether UV radiation induces TLR4 expression in neonatal human melanocytes (NHMs) and how this affects the immune system. METHODS: We cultured NHMs with LPS treatment or with one-time or repeated UVA or UVB exposure, and investigated and compared the effects on TLR4 expression, melanin contents, and cytokine production...
October 24, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29049844/flavonoids-inhibit-chronically-exposed-arsenic-induced-proliferation-and-malignant-transformation-of-hacat-cells
#12
Mohit Rajput, Praveen Kumar Kujur, Abhijeet Mishra, Rana P Singh
BACKGROUND: Apart from exposure to UV-radiation, studies show relationship between skin cancer and chronic ingestion of arsenic through drinking water. Chemopreventive strategies could help in reducing the toxic effects of arsenic and arsenic-induced skin cancer. METHODS: Cytotoxicity of arsenic on human skin keratinocytes HaCaT cells was evaluated using MTT and trypan blue assays. Arsenic-induced malignant transformant HaCaT cells were selected through soft agar colony assay...
October 19, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29044786/unique-profile-of-antimicrobial-peptides-expression-in-polymorphic-light-eruption-lesions-compared-to-healthy-skin-atopic-dermatitis-and-psoriasis
#13
VijayKumar Patra, Gerlinde Mayer, Alexandra Gruber-Wackernagel, Michael Horn, Serena Lembo, Peter Wolf
BACKGROUND: Polymorphic light eruption (PLE) has been attributed to type IV, most likely delayed-type hypersensitivity response (adaptive immunity) but little is known on innate immunity, especially antimicrobial peptides (AMPs) in the disease. Abnormalities in AMP expression have been linked to pathological skin conditions such as atopic dermatitis (AD) and psoriasis. METHODS: AMP profiling was done in PLE skin samples (n,12) compared with that of healthy (n,13), atopic (n,6) and psoriatic skin (n,6)...
October 16, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29044724/tea-polyphenols-for-the-prevention-of-uvb-induced-skin-cancer
#14
REVIEW
Pooja Sharma, Mary Katherine Montes de Oca, Amena R Alkeswani, Sarah F McClees, Tanushree Das, Craig A Elmets, Farrukh Afaq
Skin cancer is the most common type of cancer with increasing incidence rate and public health burden. Solar Ultraviolet (UV) radiation causes an array of damaging cellular and molecular events that eventually lead to the development of skin cancer. Despite increased awareness about sun protection, the exposure rate remains high with less than 15% of men and 30% of women using sunscreen on a regular basis. Therefore, there is an imperative need for the development of novel preventive approaches. Skin cancer chemoprevention using phytochemicals either as dietary supplements or by topical applications has gained considerable attention due to their low toxicity, availability, and anti-carcinogenic properties...
October 16, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28976044/prevalence-and-predictors-of-sunburn-among-beachgoers
#15
M de Troya-Martín, M V de Gálvez-Aranda, F Rivas-Ruiz, N Blázquez-Sánchez, M T Fernández-Morano, L Padilla-España, E Herrera-Ceballos
BACKGROUND: Painful sunburns at any age are one of the main risk factors for skin cancer. OBJECTIVES: To determine the prevalence and predictors of sunburn among beachgoers. METHODS: A cross-sectional health survey was conducted at the beach during the summer. Adults > 18 years with an understanding of Spanish were interviewed using a questionnaire about behaviours, attitudes and knowledge related to sun exposure at the beach. A descriptive analysis was performed and a log binomial regression model was used to determine predictors of sunburn...
October 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28976029/epigenetics-of-skin-cancer-interventions-by-selected-bioactive-phytochemicals
#16
REVIEW
Dhanamjai Penta, Bagganahalli S Somashekar, Syed Musthapa Meeran
The prevalence and risk of skin cancer have been increasing over past three decades. Two major types of skin cancer observed in humans are melanoma and non-melanoma. Non-melanoma further subdivided into basal cell carcinoma and squamous cell carcinoma. Melanoma arises from melanocyte which locates at the bottom layer of skin epidermis, which primarily protects the skin from being exposed to external factors. Melanoma is less common among all other types of skin cancers but causes higher mortality. Epigenetic regulation associated with the transcriptional activation and inactivation of genes plays a major role in various disease progression including skin cancer...
October 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28976023/matrix-metalloproteinase-in-acral-and-non-acral-vitiligo
#17
LETTER
Samia Esmat, Dalia Mohamed Abdel Halim, Rehab Hegazy, Safinaz Sayed, Marwah Adly Saleh
Repigmentation in vitiligo requires activation, proliferation and migration of the melanoblasts and melanocytes into the depigmented epidermis (1). Cell migration involves modifications of the architecture of cells which requires activation of enzymes that are involved in ECM degradation such as matrix metalloproteinases (MMPs). The significant reduction of their expression in vitiliginous skin has been previously demonstrated (2) and thereby incriminated to share in reducing the migration of melanocytes and their precursors...
October 4, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29171149/abstracts
#18
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28884844/an-open-label-clinical-trial-assessing-the-efficacy-and-safety-of-bend-skincare-anti-aging-formula-on-minimal-erythema-dose-in-skin
#19
Nancy L Morse, Anna-Jean Reid, Marc St-Onge
BACKGROUND/PURPOSE: Sunburn and other health risks associated with excess sun exposure place huge economic burdens on societies, and create discomfort and disease within susceptible individuals. Oral supplements that reduce sunburn may be advantageous. This study evaluated the safety and efficacy of Bend Skincare Anti-Aging Formula to ameliorate sunburn induced with a solar simulator. METHODS: Subjects (n = 28) with Fitzpatrick skin phototypes I, II, or III took 4 capsules daily of the supplement providing 1400 mg of eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), 120 mg of gamma-linolenic acid (GLA), 5 mg of lutein, 2...
September 8, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28875578/are-tanning-salons-in-compliance-with-german-law-an-evaluation-based-on-a-nationwide-representative-survey
#20
Tatiana Görig, Sven Schneider, Rüdiger Greinert, Eckhard W Breitbart, Katharina Diehl
BACKGROUND: Given the evidence for increased skin cancer risk due to the sunbed use, a regulation of hazardous artificial ultraviolet radiation (UVR regulation) was passed in Germany in 2012. The aim of this study was to explore the advisory services in tanning studios as reported by sunbed users and to evaluate the information provided by the personnel of tanning salons after the UVR regulation was enacted. METHODS: The first wave of the representative National Cancer Aid Monitoring on Sunbed Use included a subgroup of 357 German citizens between 14 and 45 years who had used sunbeds since the UVR regulation was implemented...
September 6, 2017: Photodermatology, Photoimmunology & Photomedicine
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