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Journal of Materials Science. Materials in Medicine

María Pleguezuelos-Villa, Amparo Nácher, María Jesús Hernández, M A Ofelia Vila Busó, María Barrachina, Nuria Peñalver, Octavio Díez-Sales
Periodontal diseases are inflammatory disorders caused primarily by dental plaque microorganisms that even may need surgery to remove damaged tissue. Adhesive biocompatible films may be an adequate form in order to improve drug retention or prevent microbial infections by covering the surgical site. In recent years, much attention has been focused on biocompatible inexpensive polymers, for biomedical and pharmaceutical potential applications. The objective of this research is the development of a film for mucosal application containing lidocaine hydrochloride (5%, w/w) as anesthetic drug...
January 11, 2019: Journal of Materials Science. Materials in Medicine
M Monsoor Shaik, Ashwin Dapkekar, Jyutika M Rajwade, Sachin H Jadhav, Meenal Kowshik
Tissue engineering techniques are continuously evolving towards providing better microenvironment along with therapeutic potential to address the skin tissue defects. Factors such as microbial infections, presence of excessive free radicals and depletion in antioxidant based scavenging systems pose serious challenges by prolonging inflammation and delaying the repair process. Incorporation of bioactive molecules in polymer based biomimetic scaffolds may present new vistas for handling chronic wounds. In this study, chitosan/collagen scaffolds incorporating 0...
January 11, 2019: Journal of Materials Science. Materials in Medicine
Edilene Gadelha de Oliveira, Paula Renata Lima Machado, Kleber Juvenal Silva Farias, Tiago R da Costa, Dulce Maria Araújo Melo, Ariane Ferreira Lacerda, Matheus de Freitas Fernandes-Pedrosa, Alianda Maira Cornélio, Arnóbio Antônio da Silva-Junior
Drug delivery systems can overcome cancer drug resistance, improving the efficacy of chemotherapy agents. Poly (lactic acid) (PLA) microparticles are an interesting alternative because their hydrophobic surface and small particle size could facilitate interactions with cells. In this study, two poloxamers (PLX 407 and 188) were applied to modulate the structural features, the drug release behavior and the cell viability from spray-dried microparticles. Five formulations with different PLA: PLX blend ratio (100:0, 75:25, 50:50, 25:50, and 0:100) were well-characterized by SEM, particle size analysis, FTIR spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction analysis (XRD)...
January 8, 2019: Journal of Materials Science. Materials in Medicine
Feilong Zhou, Zhimei Song, Yi Wen, Hongmei Xu, Li Zhu, Runliang Feng
Curcumin (CUR) is a hydrophobic polyphenol with anti-inflammatory activity. However, its low water-solubility and poor skin permeation limited its application in the treatment of dermititis. CUR-loaded micelles were prepared using thin membrane hydration method with methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) (MPEG-PCL) as carrier material. The drug loading capacity and encapsulation efficiency were 12.14 ± 0.33 and 93.57 ± 1.67%, respectively. CUR-loaded micelles increased CUR's water-solubility to 1...
January 8, 2019: Journal of Materials Science. Materials in Medicine
Ella Hodder, Sarah Duin, David Kilian, Tilman Ahlfeld, Julia Seidel, Carsten Nachtigall, Peter Bush, Derek Covill, Michael Gelinsky, Anja Lode
For both the incorporation of cells and future therapeutic applications the sterility of a biomaterial must be ensured. However, common sterilisation techniques are intense and often negatively impact on material physicochemical attributes, which can affect its suitability for tissue engineering and 3D printing. In the present study four sterilisation methods, autoclave, supercritical CO2 (scCO2 ) treatment, UV- and gamma (γ) irradiation were evaluated regarding their impact on material properties and cellular responses...
January 4, 2019: Journal of Materials Science. Materials in Medicine
F Ruther, T Distler, A R Boccaccini, R Detsch
One of the key challenges in the field of blood vessel engineering is the in vitro production of small and large diameter vessels. Considering that a combination of alginate di-aldehyde and gelatin (ADA-GEL) has been successfully applied for different biofabrication approaches, the aim of this study was to exploit ADA-GEL for the fabrication of vessel structures with diameters up to 4 mm. To explore plotting possibilities and to study the swelling behaviour, a library of vessel-like constructs with different diameters made from 2, 3 and 4% (w/v) alginate was created by using various hand-crafted double-needle extrusion systems...
December 29, 2018: Journal of Materials Science. Materials in Medicine
Silvia Stella Ramirez Caballero, Eduardo Saiz, Alexandra Montembault, Solène Tadier, Eric Maire, Laurent David, Thierry Delair, Laurent Grémillard
Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Inks consisted of suspensions of calcium phosphate particles in chitosan acidic aqueous solution. The inks are shear-thinning and consist of a suspension of dispersed platelet aggregates of dicalcium phosphate dihydrate in a continuous chitosan phase...
December 29, 2018: Journal of Materials Science. Materials in Medicine
Tingwang Guo, Xin Yang, Jia Deng, Liancai Zhu, Bochu Wang, Shilei Hao
Keratin has the potential to improve biocompatibility and bioactivity of polymeric nanofibers. However, the addition of keratin into the blend nanofiber would decrease the mechanical properties of nanofibers due to the poor spinnability of keratin, and caused inhomogeneous distribution of keratin inside the nanofibers. Therefore, polymeric nanofibers surface-modified with keratin nanoparticles would improve the hydrophility and mechanical property. In this study, keratose (oxidative keratin, KOS) nanoparticles-coating PVA nanofibers (KNPs/PVA) were fabricated by electrospray deposition after electrospinning and acted on neural cells...
December 29, 2018: Journal of Materials Science. Materials in Medicine
Mohammad Askari, Shahin Bonakdar, Mahdi Habibi Anbouhi, Hosein Shahsavarani, Saeid Kargozar, Vahid Khalaj, Mohammad Ali Shokrgozar
Strategies based on growth factor (GF) delivery have attracted considerable attention in tissue engineering applications. Among different GFs, transforming growth factor beta 1 (TGF-β1) is considered to be a potent factor for inducing chondrogenesis. In the present study, an expression cassette encoding the TGF-β1 protein was prepared and transfected into the SP2/0-Ag14 cell line. The confocal microscopy of the transfected cells was performed to confirm the correct transfection process. The expression and in vitro release kinetics of the recombinant TGF-β1 were assessed by western blot analysis and ELISA, respectively...
December 29, 2018: Journal of Materials Science. Materials in Medicine
Bin Liu, Xiyuan Gao, Zhaozhong Sun, Qingmin Fang, Xiaopeng Geng, Hanli Zhang, Guanglin Wang, Yongfeng Dou, Peng Hu, Kai Zhu, Dawei Wang, Jianqiang Xing, Dong Liu, Min Zhang, Rui Li
The purpose of our study is to prepare a biomimetic porous silk fibroin (SF)/biphasic calcium phosphate (BCP) scaffold, and evaluate its performance in bone tissue regeneration. The differences in pore size, porosity, mechanical strength and biocompatibility of four different fibroin-containing scaffolds (0, 20, 40, and 60% SF) were studied in vitro. After inoculation with MC3T3-E1 cells, the ectopic bone formation ability of the SF/BCP bionic scaffold was evaluated in a rat model. The SEM and CT demonstrated that compared with pure BCP group (0% SF), the pore size and porosity of SF/BCP scaffolds were proportional to SF content, of which 40% of SF and 60% of SF groups were more suitable for cell growth...
December 19, 2018: Journal of Materials Science. Materials in Medicine
Guihua Han, Baolin Zhang, Hao Zhang, Dong Han, Jie Tan, Boning Yang
Glutathione-modified superparamagnetic iron oxide nanoparticles (GSH-SPIONs) were prepared by conjugating glutathione (GSH) on the surface of the PEG (Polyethylene glycol)/PEI (polyethyleneimine)-SPIONs which were synthesized by thermal decomposition method. Thermogravimetric analysis showed that the mass fraction of GSH on the surface of SPIONs was 30.64 wt%. GSH-SPIONs in PBS were injected into the substantia nigra of rat brains. The subcellular distributions of the nanoparticles in the brains was examined by the transmission electron microscope (TEM)...
December 19, 2018: Journal of Materials Science. Materials in Medicine
Fei Ge, Qianqian Qiao, Longbao Zhu, Wanzhen Li, Ping Song, Longlong Zhu, Yugui Tao, Lin Gui
A new tumor-targeted drug-loading material, the amphiphilic peptide DGRGGGAAAA (P10) was designed and synthesized, and its self-assembly behavior, drug-loading effects and in vitro characteristics were studied. P10 was synthesized by solid-state synthesis and doxorubicin (DOX) was loaded via dialysis. P10 and DOX were mixed with a mass ratio of 6:1 to form regular round spheres. The interconnection between groups was analyzed spectroscopically and the sphere morphology was studied with SEM and a zeta particle size analyzer...
December 19, 2018: Journal of Materials Science. Materials in Medicine
Shahrbanoo Jahangir, Samaneh Hosseini, Farhad Mostafaei, Forough Azam Sayahpour, Mohamadreza Baghaban Eslaminejad
Hypoxia-inducible factor-1α (HIF-1α), a well-studied angiogenesis pathway, plays an essential role in angiogenesis-osteogenesis coupling. Targeting the HIF-1a pathway frequently leads to successful reconstruction of large-sized bone defects through promotion of angiogenesis. Dimethyloxalylglycine (DMOG) small molecule regulates the stability of HIF-1α at normal oxygen tension by mimicking hypoxia, which subsequently accelerates angiogenesis. The current study aims to develop a novel construct by seeding adipose derived mesenchymal stem cells (ADMSCs) onto a scaffold that contains DMOG to induce angiogenesis and regeneration of a critical size calvarial defect in a rat model...
December 18, 2018: Journal of Materials Science. Materials in Medicine
Meng Zhang, Xuejiu Wang, Xiaobo Huang, Yongkang Wang, Ruiqiang Hang, Xiangyu Zhang, Xiaohong Yao, Bin Tang
In this study, an oxide layer on Ti-based implants is fabricated by using a high current anodization (HCA) technique in the nitrate electrolyte. This layer is composed of micro-pits and nano-porous arrays in the honeycomb structure. The results show that both the roughness and the layer thickness are related to the reaction time, whereas the size of nano-pores has little to do with the anodization duration. Compared to the nano-tubular arrays constructed by the conventional anodization, this nano-porous layer shows significantly improved mechanical stability...
December 18, 2018: Journal of Materials Science. Materials in Medicine
Sarfaraz Ahmad, Muhammad Usman Minhas, Mahmood Ahmad, Muhammad Sohail, Qandeel Khalid, Orva Abdullah
The aim of the study was to synthesize and evaluate chitosan-based topical cross-linked hydrogel membranes of mupirocin for new pharmaceutical controlled release application. These cross-linked structured membranes were synthesized by modification of free radical polymerization. Low molecular weight (LMW) chitosan is cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with a crosslinker N,N-methylenebisacrylamide (MBA). Hydrogel membranes were characterized by FTIR, DSC, TGA, SEM, Swelling behavior, sol-gel analysis, in vitro percent drug release at different pH, permeation across skin, ex vivo drug deposition study, irritation study and in vivo antibacterial activity of mupirocin loaded hydrogels...
December 11, 2018: Journal of Materials Science. Materials in Medicine
Bojana Ćetenović, Božana Čolović, Saša Vasilijić, Bogomir Prokić, Snežana Pašalić, Vukoman Jokanović, Zvezdana Tepavčević, Dejan Marković
The aim of this study was to investigate the biocompatibility of nanostructured materials based on highly active calcium silicates mixed with different radiocontrast agents in comparison to MTA+ using in vitro and in vivo model. Morphology of materials' samples was analyzed using SEM while the phase compositions were identified by XRD. pH values of materials' suspensions were conducted by pH-meter. The cytotoxicity of materials' solutions was tested by MTT test (100, 50, 25 and 12.5 mg/ml). LDH and 3 H-thymidine assay were utilized for biocompatibility investigations of materials' eluates (24 h, 7 day and 21 day)...
December 10, 2018: Journal of Materials Science. Materials in Medicine
Adel Badria, Petros Koutsoukos, Sotirios Korossis, Dimosthenis Mavrilas
The original version of this article unfortunately contained a few errors. The captions of Figs. 4, 5, 6, 7, and 8 were mixed up and they were misreferred in the text. The correct captions and their references in text are given below.
December 10, 2018: Journal of Materials Science. Materials in Medicine
Weiyi Pan, Xun Xiao, Jinle Li, Shibing Deng, Qin Shan, Yuan Yue, Ye Tian, Neel R Nabar, Min Wang, Liang Hao
The applications of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) in tissue engineering have been widely studied. This study aimed to compare the biocompatibility and osteoinductivity of single-walled carbon nanotubes (SWCNTs)/PHBV composites with multi-walled CNTs (MWCNTs)/PHBV composites. CNTs were dispersed in PHBV by ultrasonication and composites were created using thermal injection moulding. In order to test their biocompatibility and osteoinductivity. Rat osteoblasts (rOBs) were then cultured and seeded on the composites...
December 10, 2018: Journal of Materials Science. Materials in Medicine
Hao Li, Tingting Ma, Man Zhang, Jiani Zhu, Jie Liu, Fei Tan
To improve the biological performance of poly(ethylene glycol)-diacrylate (PEGDA) hydrogel as an injectable bone grafting scaffold, sodium methallyl sulphonate (SMAS) was incorporated into PEGDA hydrogel. The physiochemical properties of the resultant polymers were assessed via Fourier transform infrared spectroscopy (FTIR), swelling ratio, zeta potential, surface morphology, and protein adsorption analysis. MC3T3-E1 cells were seeded on the hydrogel to evaluate the effect of the sulphonated modification on their attachment, proliferation, and differentiation...
December 7, 2018: Journal of Materials Science. Materials in Medicine
Atul P Sherje, Mrunal Jadhav
Rivaroxaban (RIV) is an oral anticoagulant used in the prevention of venous thromboembolism in adult patients after total hip replacement or total knee replacement surgery. It is practically insoluble in water and buffer systems (pH 3-9). The present study was aimed to investigate the β-CD-based inclusion complexes and nanocomposites of rivaroxaban (RIV) for solubility and dissolution enhancement. A novel solubility enhancement approach of inclusion complexation of RIV with β-CD using spray drying method combined with high pressure homogenization as a particle engineering method was used...
December 6, 2018: Journal of Materials Science. Materials in Medicine
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