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Journal of Materials Science. Materials in Medicine

Lei Zhang, Guannan Hu, Yan Du, Lei Gao, Haishan Qi
In this work, poly(carboxybetaine methacrylate) hydrogel (pCBMA) was employed to modify the activated carbon (AC) for improving the biocompatibility and adsorption capacity of AC in biological environments. First, size-controlled hydrogel beads and hydrogel coated AC (pCBMA-AC) were fabricated with a homemade device, and the preparation conditions were optimized. Then the physical and biological properties of pCBMA-AC with different diameters were investigated. 2 mm pCBMA-AC dispalyed excellent stability with leakage rate only 0...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Naihao Lu, Yinhua Sui, Yun Ding, Rong Tian, Yi-Yuan Peng
Carbon nanotubes are widely used in the area of biomedicine, and the binding of protein to carbon nanotubes are believed to play an important role in the potential cytotoxicity of nanomaterials. In this work, we investigated the effects of human fibrinogen-surface coatings on the biodegradation and cytotoxicity of carboxylated single-walled carbon nanotubes (SWCNTs). It was found that the electrostatic and π-π stacking interactions might be the crucial factors in stabilizing the binding of fibrinogen with SWCNTs by both theoretical and experimental approaches...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Justyna Witkowska, Agnieszka Sowińska, Elżbieta Czarnowska, Tomasz Płociński, Bogusław Rajchel, Michał Tarnowski, Tadeusz Wierzchoń
A hybrid process that combines oxidation under glow-discharge conditions with ion beam-assisted deposition (IBAD) has been applied to mechanically polished NiTi shape memory alloy in order to produce composite surface layers consisting of a TiO2 layer and an external carbon coating with an addition of silver. The produced surface layers a-C(Ag) + TiO2 type have shown increased surface roughness, improved corrosion resistance, altered wettability, and surface free energy, as well as reduced platelet adhesion, aggregation, and activation in comparison to NiTi alloy in initial state...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Inari Avila, Konstantin Pantchev, Jani Holopainen, Mikko Ritala, Juha Tuukkanen
The purpose of this study was to evaluate the mechanical properties of nanocrystalline hydroxyapatite coating by tensile adhesion testing and scratch testing. The coating was manufactured on titanium substrate by converting atomic layer-deposited (ALD) calcium carbonate thin film in dilute phosphate solution. The tensile adhesion testing was performed with hydraulic testing device in accordance with ISO 4624 and ISO 16276-1. Scratch testing was done according to SFS-EN 13523-12 with spherical 10 µm scratching tip...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Gaoke Feng, Chaoshi Qin, Xin Yi, Jinggang Xia, Jingjing Chen, Xiyu Chen, Tao Chen, Xuejun Jiang
To study the effect of novel bioresorbable scaffold composed of poly-L-lactic acid (PLLA) and amorphous calcium phosphate (ACP) nanoparticles on inflammation and calcification of surrounding tissues after implantation. Ninety six PLLA/ACP scaffolds and 96 PLLA scaffolds were randomly implanted in the back muscle tissue of 48 SD rats. At the 1st, 2nd, 4th, and 12th weeks after implantation, the calcium, phosphorus, and alkaline phosphatase levels in the blood serum and the contents of calcium and alkaline phosphatase in the tissue surrounding the scaffolds were measured...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Chundong Liu, Jianhua Wang, Sheng Huang, Lin Yu, Yan Wang, Hang Chen, Dong Wang
Peptide nucleic acid (PNA) holds enormous potentials as antisense/antigenic drug due to its specific binding ability and biostability with DNA or RNA. However, the poor cellular delivery is the key obstacle in development of PNA therapy. To overcome this difficulty, we developed self-assembled nanoparticles (NPs) for delivery of PNA to living cells using amphiphilic CS derivatives. A series of N,N,N-trimethyl-O-alkyl chitosans (TMACs) with different lengths of alkyl chains were synthesized. The structures of these synthesized chemicals were characterized with FT-IR and 1 H NMR...
July 17, 2018: Journal of Materials Science. Materials in Medicine
Erika Daley, Michael D Kurdziel, Denise Koueiter, Drew D Moore
Percutaneous doxycycline for treatment for aneurysmal bone cysts (ABCs) has been shown to decrease recurrence rates, however, this requires multiple procedures, includes the risks soft tissue necrosis, and does not provide structural support. We propose utilizing curettage with doxycycline-loaded calcium phosphate cement. This study aimed to evaluate the elution profile of doxycycline from calcium phosphate cement. Calcium phosphate cement underwent an in vitro elution protocol evaluating doxycycline concentrations of 0, 5, 10, and 15 mg/mL...
July 10, 2018: Journal of Materials Science. Materials in Medicine
Xi Song, Siyuan Cui, Zhentao Li, Yanpeng Jiao, Changren Zhou
Chitin/graphene oxide (Ch/GO) composite sponges had been synthesized in 11 wt% NaOH/4 wt% urea aqueous solution by a simple method. The structure, thermal stability and mechanical properties of the composite sponges were investigated by scanning electron microscopy, Fourier-transform infrared spectroscopy, wide-angle X-ray diffraction, thermogravimetric analysis, and compressive strength measurements. The results revealed that chitin and GO were mixed homogeneously. Interestingly, the composite sponges showed meso-macroporous structure, which played an important role in improving their adsorption properties...
July 6, 2018: Journal of Materials Science. Materials in Medicine
Piotr Wilczek, Gach Paulina, Jendryczko Karolina, Marcisz Martyna, Wilczek Grazyna, Major Roman, Mzyk Aldona, Sypien Anna, Samotus Aneta
Currently available bioprosthetic heart valves have been successfully used clinically; however, they have several limitations. Alternatively, tissue-engineering techniques can be used. However, there are limited data concerning the impact of storage conditions of scaffolds on their biomechanics and morphology. The aim of this study was to determine the effect of different storage conditions on the biomechanics and morphology of pulmonary valve dedicated for the acellular scaffold preparation to achieve optimal conditions to obtain stable heart valve prostheses...
July 3, 2018: Journal of Materials Science. Materials in Medicine
İrem Türkcan, A Dilek Nalbant, Erhan Bat, Gülçin Akca
The aim of this study is to evaluate the effects of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer coating with various concentrations onto acrylic resin denture base material on surface characteristics such as contact angle and surface roughness and on Candida albicans adhesion which is the major factor of denture stomatitis. Specimens, prepared from heat-polymerized acrylic denture base material, were divided into control and three test groups, randomly. Surfaces of the specimens in test groups were coated with poly(MPC) (PMPC) by graft polymerization of MPC in different concentrations (0...
July 3, 2018: Journal of Materials Science. Materials in Medicine
Kohei Murase, Patrik Stenlund, Peter Thomsen, Jukka Lausmaa, Anders Palmquist
In the present study, a model for simulations of removal torque experiments was developed using finite element method. The interfacial retention and fracturing of the surrounding material caused by the surface features during torque was analyzed. It was hypothesized that the progression of removal torque and the phases identified in the torque response plot represents sequential fractures at the interface. The 3-dimensional finite element model fairly accurately predicts the torque required to break the fixation of acid-etched implants, and also provides insight to how sequential fractures progress downwards along the implant side...
June 30, 2018: Journal of Materials Science. Materials in Medicine
André Schulz, Alisa Katsen-Globa, Esther J Huber, Sabine C Mueller, Asger Kreiner, Norbert Pütz, Michael M Gepp, Benjamin Fischer, Frank Stracke, Hagen von Briesen, Julia C Neubauer, Heiko Zimmermann
The surface charge of a biomaterial represents a promising tool to direct cellular behavior, which is crucial for therapeutic approaches in regenerative medicine. To expand the understanding of how the material surface charge affects protein adsorption and mesenchymal stem cell behavior, differently charged surfaces with zeta potentials spanning from -25 mV to +15 mV were fabricated by the conjugation of poly(amidoamine) to alginate-based hydrogels. We showed that the increase of the biomaterials surface charge resulted in enhanced quantities of biologically available, surface-attached proteins...
June 30, 2018: Journal of Materials Science. Materials in Medicine
Joana M Ramis, Javier Calvo, Aina Matas, Cristina Corbillo, Antoni Gayà, Marta Monjo
Osteoinductive capacity of demineralized bone matrix (DBM) is sometimes insufficient or shows high variability between different batches of DBM. Here, we tried to improve its osteoinductive activity by alkali-urea or trypsin treatment but this strategy was unsuccessful. Then, we tested the enrichment of DBM with a bone protein extract (BPE) containing osteogenic growth factors comparing two sources: cortical bone powder and DBM. The osteoinductive capacity (alkaline phosphatase activity) of the obtained BPEs was evaluated in vitro in C2C12 cells...
June 28, 2018: Journal of Materials Science. Materials in Medicine
Chaoyu Liu, Xiaohua Li, Feiyue Xu, Haibo Cong, Zongxian Li, Yuan Song, Min Wang
Scaffolds capable of providing dual neurotrophic factor (NTF) delivery with different release kinetics, spatial delivery of NTFs at different loci and topographical guidance are promising for enhanced peripheral nerve regeneration. In this study, we have designed and fabricated multi-layered aligned-fiber scaffolds through combining emulsion electrospinning, sequential electrospinning and high-speed electrospinning (HS-ES) to modulate the release behavior of glial cell line-derived growth factor(GDNF) and nerve growth factor (NGF)...
June 28, 2018: Journal of Materials Science. Materials in Medicine
J V Ríos-Santos, A M Menjívar-Galán, M Herrero-Climent, B Ríos-Carrasco, A Fernández-Palacín, R A Perez, F J Gil
Several dental implants are commercially available and new prototype design are constantly being fabricated. Nevertheless, it is still unclear what parameters of the design affect most the osseointegration of dental implants. The purpose of this study is to assess the effects of the microscopic and macroscopic design of dental implants in the osseointegration by comparing three macroscopic designs (Straumann tissue level (STD), essential cone (ECD) and prototype design (PD)) and six surface treatments. A total of 96 implants were placed in 12 minipigs...
June 26, 2018: Journal of Materials Science. Materials in Medicine
Zena G M Azzawi, Thekra I Hamad, Shehab A Kadhim, Ghassan Abdul-Hamid Naji
The nanotechnology field plays an important role in the improvement of dental implant surfaces. However, the different techniques used to coat these implants with nanostructured materials can differently affect cells, biomolecules and even ions at the nano scale level. The aim of this study is to evaluate and compare the structural, biomechanical and histological characterization of nano titania films produced by either modified laser or dip coating techniques on commercially pure titanium implant fixtures...
June 26, 2018: Journal of Materials Science. Materials in Medicine
Vincenzo Farano, Mark Cresswell, Kerstin Gritsch, Phil Jackson, Nina Attik, Brigitte Grosgogeat, Jean-Christophe Maurin
Phosphate-based glasses have been attracting attention due to their possible medical applications arising from unique dissolution characteristics in the human body leading to the possibility of new tissue regeneration. In this study, the leaching kinetics of a series of melt-quenched Sr-doped phosphate glasses are presented. Regardless of the presence of Sr, all the glasses have an initial linear and sustained release of the ions followed by a plateau. To guarantee proper nutritional support to the growing tissue during regeneration and to mimic the 3-dimensional architecture of tissues, organic scaffold systems have been developed...
June 26, 2018: Journal of Materials Science. Materials in Medicine
Chrystalleni Hadjicharalambous, Chara Flouraki, Ravin Narain, Maria Chatzinikolaidou, Maria Vamvakaki
Controlling the cell behavior on biocompatible polymer surfaces is critical for the development of suitable medical implant coatings as well as in anti-adhesive applications. Synthetic glycopolymer brushes, based on sugar methacrylate monomers have been reported as robust surfaces to resist protein adsorption and cell adhesion. In this study, poly(D-gluconamidoethyl methacrylate) (PGAMA) brushes of various chain lengths were synthesized directly from initiator functionalized glass substrates using surface-initiated atom transfer radical polymerization...
June 26, 2018: Journal of Materials Science. Materials in Medicine
Tong-Jing Fang, Ding-Han Wang, Chia-Yu Wang, Raju Poongodi, Nien-Hsien Liou, Jiang-Chuan Liu, Ming-Lun Hsu, Po-Da Hong, Shih-Fang Yang, Meng-Lun Liu
The original version of this article unfortunately contained a mistake. The country was incorrect in the authors affiliations. It should read as "ROC". The corrected affiliations are given below.
June 26, 2018: Journal of Materials Science. Materials in Medicine
Maria Bousnaki, Athina Bakopoulou, Danai Papadogianni, Nektaria-Marianthi Barkoula, Kalliopi Alpantaki, Aristidis Kritis, Maria Chatzinikolaidou, Petros Koidis
Tissue engineering (TE) may provide effective alternative treatment for challenging temporomandibular joint (TMJ) pathologies associated with disc malpositioning or degeneration and leading to severe masticatory dysfunction. Aim of this study was to evaluate the potential of chitosan/alginate (Ch/Alg) scaffolds to promote fibro/chondrogenic differentiation of dental pulp stem cells (DPSCs) and production of fibrocartilage tissue, serving as a replacement of the natural TMJ disc. Ch/Alg scaffolds were fabricated by crosslinking with CaCl2 combined or not with glutaraldehyde, resulting in two scaffold types that were physicochemically characterized, seeded with DPSCs or human nucleus pulposus cells (hNPCs) used as control and evaluated for cell attachment, viability, and proliferation...
June 26, 2018: Journal of Materials Science. Materials in Medicine
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