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Journal of Materials Science. Materials in Medicine

Jiasi Luo, Songquan Wu, Yanjin Lu, Sai Guo, Yang Yang, Chaoqian Zhao, Junjie Lin, Tingting Huang, Jinxin Lin
Microstructure, tribological property and corrosion resistance of orthopedic implant materials CoCrW-3 wt.% Cu fabricated by selective laser melting (SLM) process were systematically investigated with CoCrW as control. Equaxied γ-phase together with the inside {111} < 112 > type twin and platelet ε-phase was found in both the Cu-bearing and Cu-free alloys. Compared to the Cu-free alloy, the introduction of 3 wt.% Cu significantly increased the volume fraction of the ε-phase. In both alloys, the hardness of ε-phase zone was rather higher (~4 times) than that of γ-phase zone...
March 19, 2018: Journal of Materials Science. Materials in Medicine
Feng Fu, Xiang Zhu, Zhe Qin, Jing-Jing Wang, Chao Xu, Li-Na Wang, Yue Tu, Sai Zhang, Rui-Xin Li, Xiao-Hong Li, Ming-Liang Zhao
Degradation rate is an important index for evaluating biomaterials. The authors' aim was to determine whether the degradation rate of biomaterials is different in distinct tissues and to clarify the underlying mechanism of degradation. The collagen-chitosan (CG-CS) composite scaffolds were prepared using freeze-drying technology. The porosity, water absorption and swelling ratio of the scaffolds were tested in vitro. The scaffolds were implanted into the subcutis, spinal cord and brain tissues of SD rats, the rate of degradation was assessed by continuous monitoring of weight loss, the pathological changes of target areas were observed by histological staining, and matrix metalloproteinase 9 (MMP-9) and lysozyme were detected at the rapid stage of degradation of the scaffolds...
March 19, 2018: Journal of Materials Science. Materials in Medicine
M Di Giulio, V Di Valerio, D Bosco, E Marsich, A Cataldi, L Cellini, S Sancilio
The molecular mechanisms leading to Streptococcus mitis capability of entering oral cells were investigated in a co-culture of S. mitis and Human Gingival Fibroblasts (HGFs) in the presence of saliva. An innovative colloidal solution based on silver nanoparticles (Chitlac-nAg), a promising device for daily oral care, was added to the experimental system in order to study the effects of silver on the bacterial overgrowth and ability to enter non-phagocytic eukaryotic cells. The entry of bacteria into the eukaryotic cells is mediated by a signalling pathway involving FAK, integrin β1, and the two cytoskeleton proteins vinculin and F-actin, and down-regulated by the presence of saliva both at 3 and 48 h of culture, whereas Chitlac-n Ag exposure seems to influence, by incrementing it, the number of bacteria entering the fibroblasts only at 48 h...
March 19, 2018: Journal of Materials Science. Materials in Medicine
Satoshi Sakoda, Noriko Nakao, Ikuya Watanabe
The aim was to investigate the effect of machining instruments on machinability of dental ceramics. Four dental ceramics, including two zirconia ceramics were machined by three types (SiC, diamond vitrified, and diamond sintered) of wheels with a hand-piece engine and two types (diamond and carbide) of burs with a high-speed air turbine. The machining conditions used were abrading speeds of 10,000 and 15,000 r.p.m. with abrading force of 100 gf for the hand-piece engine, and a pressure of 200 kPa and a cutting force of 80 gf for the air-turbine hand-piece...
March 16, 2018: Journal of Materials Science. Materials in Medicine
Mikhail A Sevost'yanov, Elena O Nasakina, Alexander S Baikin, Konstantin V Sergienko, Sergey V Konushkin, Mikhail A Kaplan, Alexey V Seregin, Alexander V Leonov, Valery A Kozlov, Alexey V Shkirin, Nikolai F Bunkin, Alexey G Kolmakov, Sergey V Simakov, Sergey V Gudkov
A technology for obtaining materials from nanostructured nitinol with titanium- or tantalum-enriched surface layers was developed. Surface layers enriched with titanium or tantalum were shown to provide a decrease in the formation of reactive oxygen species and long-lived protein radicals in comparison to untreated nitinol. It was determined that human peripheral vessel myofibroblasts and human bone marrow mesenchymal stromal cells grown on nitinol bases coated with titanium or tantalum-enriched surface layers exhibit a nearly two times higher mitotic index...
March 15, 2018: Journal of Materials Science. Materials in Medicine
Gloria Huerta-Ángeles, Kateřina Knotková, Petr Knotek, Ondrej Židek, Martina Brandejsová, Marek Pokorný, Hana Vagnerová, Ipsita Roy, Vladimir Velebný
In this work, a hybrid copolymer consisting of poly(3-hydroxybutyrate) grafted to hyaluronic acid (HA) was synthesised and characterised. Once formed, the P(3HB)-g-HA copolymer was soluble in water allowing a green electrospinning process. The diameters of nanofibres can be tailored by simply varying the Mw of polymer. The optimization of the process allowed to produce fibres of average diameter in the range of 100-150 nm and low polydispersity. The hydrophobic modification has not only increased the fibre diameter, but also the obtained layers were homogenous...
March 15, 2018: Journal of Materials Science. Materials in Medicine
Ripon Sarkar, Aritri Ghosh, Ananya Barui, Pallab Datta
Topical application of honey for tissue regeneration, has recently regained attention in clinical practice with controlled studies affirming its efficacy and indicating its role in regeneration over repair. Parallely, to overcome difficulties of applying raw honey, several product development studies like nanofibrous matrices have been reported. However, one approach concentrated on achieving highest possible honey loading in the nanofiber membranes while other studies have found that only specific honey dilutions result in differential cellular responses on wound healing and re-epithelization...
March 13, 2018: Journal of Materials Science. Materials in Medicine
H Little, E Themistou, S A Clarke, E Cunningham, F Buchanan
The original version of this article unfortunately contained a mistake. E. Themistou was missing from the author group and so is now included with this erratum.
March 9, 2018: Journal of Materials Science. Materials in Medicine
Sourav Mandal, Susanne Meininger, Uwe Gbureck, Bikramjit Basu
One of the important aspects in 3D powder printing (3DPP) is the selection of binder for a specific material composition to produce scaffolds with desired microstructure and physico-chemical properties. To this end, a new powder-binder combination, namely tetracalcium phosphate (TTCP) and phytic acid (IP6) was investigated at ambient temperature, for low load bearing application. A minimal deviation (<200 µm, w.r.t. computer aided design) was observed in the final sample through optimization of 3DPP process, along with minimum strut and macro-pore size of 200 and 750 µm, respectively...
March 8, 2018: Journal of Materials Science. Materials in Medicine
Yoshinubo Uchihara, George Grammatopoulos, Mitsuru Munemoto, Gulraj Matharu, Yusuke Inagaki, Hemant Pandit, Yasuhito Tanaka, Nick A Athanasou
Metal-on-metal hip resurfacing arthroplasties (MoMHRAs) have a high failure rate due to pseudotumour formation. It is not certain whether pseudotumours in bilateral MoMHRAs form on the basis of an adverse reaction to metal debris (ARMD) that is entirely due to a local innate and adaptive immune response to Cobalt-Chrome (Co-Cr) wear particles. To determine if there is a systemic component to ARMD in bilateral MoMHRAs, we examined the histology of ARMD in unilateral and bilateral MoMHRAs revised for pseudotumour and determined whether implant survival differed between these two groups...
March 7, 2018: Journal of Materials Science. Materials in Medicine
Tae Hwan Park, Soon Won Chung, Seung Yong Song, Dae Hyun Lew, Tai Suk Roh, Dong Won Lee
Although there is ample evidence showing that radiation therapy increases the risk of complications of breast reconstruction, the efficacy of human acellular dermal matrix (CGCryoDerm®) in immediate tissue expander breast reconstruction in the setting of postmastectomy radiation therapy has not been fully elucidated. In this study, we report our institutional experience with pertinent refined surgical technique, and determine whether acellular dermal matrices have a protective effect in this increasingly prevalent clinical setting...
March 6, 2018: Journal of Materials Science. Materials in Medicine
Jonathan M Lawton, Mariam Habib, Bingkui Ma, Roger A Brooks, Serena M Best, Andrew L Lewis, Neil Rushton, William Bonfield
The article "The effect of cationically modified phosphorylcholine polymers on human osteoblasts in vitro and their effect on bone formation in vivo", written by Jonathan M. Lawton, Mariam Habib, Bingkui Ma, Roger A. Brooks, Serena M. Best, Andrew L. Lewis, Neil Rushton and William Bonfield, was originally published Online First without open access. After publication in volume 28, issue 9, page 144 it was noticed that the copyright was wrong in the PDF version of the article. The copyright of the article should read as "...
February 22, 2018: Journal of Materials Science. Materials in Medicine
Pierre Bourdillon, Tanguy Boissenot, Lauriane Goldwirt, Julien Nicolas, Caroline Apra, Alexandre Carpentier
In situ carmustine wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) are commonly used for the treatment of recurrent glioblastoma to overcome the brain-blood barrier. In theory, this chemotherapy diffuses into the adjacent parenchyma and the excipient degrades in maximum 8 weeks but no clinical data confirms this evolution, because patients are rarely operated again. A 75-year-old patient was operated twice for recurrent glioblastoma, and a carmustine wafer was implanted during the second surgery...
February 17, 2018: Journal of Materials Science. Materials in Medicine
Thongchai Nuntanaranont, Tapanee Promboot, Srisurang Sutapreyasri
The purpose of this study was to assess and evaluate new bone formation in rabbit marginal mandibular defects using expanded bone marrow-derived osteoprogenitor cells seeded in three-dimensional scaffolds of polycaprolactone/tricalcium phosphate (PCL/TCP). Bone marrow was harvested from the rabbit ilium and rabbit bone marrow-derived osteoprogenitor cells were isolated and expanded in standard culture medium and osteogenic medium supplement. The cells were then seeded into the PCL/TCP scaffolds and the cell/scaffold constructions were implanted into prepared defects in rabbit mandibles...
February 9, 2018: Journal of Materials Science. Materials in Medicine
Rita López-Cebral, Guangjia Peng, Lara L Reys, Simone S Silva, Joaquim M Oliveira, Jie Chen, Tiago H Silva, Rui L Reis
Oral administration of drugs presents important limitations, which are frequently not granted the importance that they really have. For instance, hepatic metabolism means an important drug loss, while some patients have their ability to swell highly compromised (i.e. unconsciousness, cancer…). Sublingual placement of an accurate Pharmaceutical Dosage Form is an attractive alternative. This work explores the use of the β-chitosan membranes, from marine industry residues, composed with marine sediments for dual sublingual drug delivery...
February 2, 2018: Journal of Materials Science. Materials in Medicine
Lorena Tarusha, Sergio Paoletti, Andrea Travan, Eleonora Marsich
Chronic non-healing wounds are a clinically important problem in terms of number of patients and costs. Wound dressings such as hydrogels, hydrocolloids, polyurethane films and foams are commonly used to manage these wounds since they tend to maintain a moist environment which is shown to accelerate re-epithelialization. The use of antibacterial compounds is important in the management of wound infections. A novel wound-dressing material based on a blended matrix of the polysaccharides alginate, hyaluronic acid and Chitlac-silver nanoparticles is here proposed and its application for wound healing is examined...
February 2, 2018: Journal of Materials Science. Materials in Medicine
Banaszewski Jacek, Pabiszczak Maciej, Pastusiak Tomasz, Buczkowska Agata, Kuczko Wiesław, Wichniarek Radosław, Górski Filip
The aim of the study was to compare two types of mandible reconstructive operations with scapula and fibula free flaps: procedures with 3-D models from thermoplastic materials and conventional planning surgeries. 8 patients were treated due to an advanced oral cavity squamous cell carcinoma. In four patients with a mandibular defect, a physical 3-D model consisting of the reconstructed and unaffected sites was prepared for a reconstruction protocol. The 3-D models were designed based to high resolution CT scans...
February 2, 2018: Journal of Materials Science. Materials in Medicine
A M Vilardell, N Cinca, N Garcia-Giralt, S Dosta, I G Cano, X Nogués, J M Guilemany
Highly rough and porous commercially pure titanium coatings have been directly produced for first time by the cold spray technology, which is a promising technology in front of the vacuum plasma spray for oxygen sensitive materials. The wettability properties as well as the biocompatibility evaluation have been compared to a simply sand blasted Ti6Al4V alloy substrate. Surface topographies were analysed using confocal microscopy. Next, osteoblast morphology (Phalloidin staining), proliferation (MTS assay), and differentiation (alkaline phosphatase activity) were examined along 1, 7 and 14 days of cell culture on the different surfaces...
February 1, 2018: Journal of Materials Science. Materials in Medicine
Tomáš Suchý, Monika Šupová, Martin Bartoš, Radek Sedláček, Marco Piola, Monica Soncini, Gianfranco Beniamino Fiore, Pavla Sauerová, Marie Hubálek Kalbáčová
Collagen composite scaffolds have been used for a number of studies in tissue engineering. The hydration of such highly porous and hydrophilic structures may influence mechanical behaviour and porosity due to swelling. The differences in physical properties following hydration would represent a significant limiting factor for the seeding, growth and differentiation of cells in vitro and the overall applicability of such hydrophilic materials in vivo. Scaffolds based on collagen matrix, poly(DL-lactide) nanofibers, calcium phosphate particles and sodium hyaluronate with 8 different material compositions were characterised in the dry and hydrated states using X-ray microcomputed tomography, compression tests, hydraulic permeability measurement, degradation tests and infrared spectrometry...
February 1, 2018: Journal of Materials Science. Materials in Medicine
Lukas Gritsch, Christopher Lovell, Wolfgang H Goldmann, Aldo R Boccaccini
Biodegradable and bioresorbable polyesters (BBPEs) are a widespread class of aliphatic polymers with a plethora of applications in the medical field. Some reports speculate that these polymers have intrinsic antibacterial activity as a consequence of their acidic degradation by-products. The release of organic acids as a result of the hydrolytic degradation of BBPEs in vivo and the resulting pH drop could be an effective inhibitor of the growth of pathogens in the local environment adjacent to BBPE-based devices...
January 16, 2018: Journal of Materials Science. Materials in Medicine
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