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Journal of Materials Science. Materials in Medicine

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https://www.readbyqxmd.com/read/28534290/wear-predictions-for-uhmwpe-material-with-various-surface-properties-used-on-the-femoral-component-in-total-knee-arthroplasty-a-computational-simulation-study
#1
Kyoung-Tak Kang, Juhyun Son, Ho-Joong Kim, Changhyun Baek, Oh-Ryong Kwon, Yong-Gon Koh
The wear of ultrahigh-molecular weight polyethylene (UHMWPE) tibial inserts in total knee arthroplasty (TKA) remains a major limitation that hinders the longevity of clinically successful devices. Surface properties significantly affect the overall performance of TKA, and surface modification with mechanically and chemically stable materials is an effective method for overcoming the wear of TKA. However, wear tests are not cost-efficient or time-efficient; thus, the effects of geometric, loading, and alignment perturbations are often evaluated via parametric studies...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534289/exposure-of-articular-chondrocytes-to-wear-particles-induces-phagocytosis-differential-inflammatory-gene-expression-and-reduced-proliferation
#2
Michael D Kurdziel, Meagan Salisbury, Lige Kaplan, Tristan Maerz, Kevin C Baker
The production of wear debris particulate remains a concern due to its association with implant failure through complex biologic interactions. In the setting of unicompartmental knee arthroplasty (UKA), damage and wear of the components may introduce debris particulate into the adjacent, otherwise, healthy compartment. The purpose of this study was to investigate the in vitro effect of polymeric and metallic wear debris particles on cell proliferation, extracellular matrix regulation, and phagocytosis index of normal human articular chondrocytes (nHACs)...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534288/physicochemical-and-biological-characterization-of-sustained-isopropyl-unoprostone-release-device-made-of-poly-ethyleneglycol-dimethacrylates
#3
Nobuhiro Nagai, Yasuko Izumida, Yoshimasa Yamazaki, Hirokazu Kaji, Junichi Kawasaki, Matsuhiko Nishizawa, Toshiaki Abe
Transscleral drug delivery is becoming increasingly popular to manage posterior eye diseases. To evaluate the clinical application of a transscleral, sustained, unoprostone (UNO)-release device (URD) constructed of photopolymerized tri(ethyleneglycol) dimethacrylate and poly(ethyleneglycol) dimethacrylate, we evaluated physicochemical and biological properties of this device. The URD consists of a drug-impermeable reservoir and a semi-permeable cover. The in vitro release rate of UNO from the URD increased with increasing temperatures from 20 to 45 °C...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534287/loading-with-vancomycin-does-not-decrease-gentamicin-elution-in-gentamicin-premixed-bone-cement
#4
Sebastian P Boelch, Martin C Jordan, Joerg Arnholdt, Maximilian Rudert, Martin Luedemann, Andre F Steinert
Antibiotic loaded bone cements are used as drug delivery systems for the treatment of periprosthetic joint infections. They can be loaded with antibiotics during industrial component production (premixing) and during cement preparation (manually blending). Although double premixed antibiotic loaded bone cements are available, manually blending of a gentamicin premixed antibiotic loaded bone cement with vancomycin is still popular. We compared in vitro antibiotic elution and compressive strength of 0.5 g gentamicin premixed bone cement (PALACOS® R + G), 0...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534286/development-of-a-novel-resin-based-dental-material-with-dual-biocidal-modes-and-sustained-release-of-ag-ions-based-on-photocurable-core-shell-agbr-cationic-polymer-nanocomposites
#5
Weiwei Cao, Yu Zhang, Xi Wang, Yinyan Chen, Qiang Li, Xiaodong Xing, Yuhong Xiao, Xuefeng Peng, Zhiwen Ye
Research on the incorporation of cutting-edge nano-antibacterial agent for designing dental materials with potent and long-lasting antibacterial property is demanding and provoking work. In this study, a novel resin-based dental material containing photocurable core-shell AgBr/cationic polymer nanocomposite (AgBr/BHPVP) was designed and developed. The shell of polymerizable cationic polymer not only provided non-releasing antibacterial capability for dental resins, but also had the potential to polymerize with other methacrylate monomers and prevented nanoparticles from aggregating in the resin matrix...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534285/development-of-self-forming-doxorubicin-loaded-polymeric-depots-as-an-injectable-drug-delivery-system-for-liver-cancer-chemotherapy
#6
Pinunta Nittayacharn, Norased Nasongkla
The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy and studied the release profiles of doxorubicin (Dox) from different depot formulations. Tri-block copolymers of poly(ε-caprolactone), poly(D,L-lactide) and poly(ethylene glycol) named PLECs were successfully used as a biodegradable material to encapsulate Dox as the injectable local drug delivery system. Depot formation and encapsulation efficiency of these depots were evaluated...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534284/transparent-bactericidal-zno-nanocoatings
#7
S K Evstropiev, K V Dukelskii, A V Karavaeva, V N Vasilyev, E V Kolobkova, N V Nikonorov, K S Evstropyev
Thin bactericidal ZnO coatings prepared with the polymer-salt method are shown to be highly transparent in the visible. The spectral measurements and XRD analysis data show that coatings prepared are formed by ZnO nanoparticles ~ 10 nm in size. The coatings demonstrate the bactericidal effect against the gram-positive Staphylococcus aureus ATCC 209P and gram-negative Escherichia coli ATCC 25922 bacteria both under the natural light and in the darkness.
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534283/cell-type-specific-extracellular-matrix-guided-the-differentiation-of-human-mesenchymal-stem-cells-in-3d-polymeric-scaffolds
#8
Yong Mao, Tyler Hoffman, Amy Wu, Ritu Goyal, Joachim Kohn
The tissue microenvironment has profound effects on tissue-specific regeneration. The 3-dimensional extracellular matrix (ECM) niche influences the linage-specific differentiation of stem cells in tissue. To understand how ECM guides tissue-specific regeneration, we established a series of 3D composite scaffolds containing ECMs derived from different primary cells isolated from a single animal species and assessed their impact on the differentiation of human mesenchymal stem cells (hMSCs). Synthetic microfiber scaffolds (fiber mats) were fabricated by electrospinning tyrosine-derived polycarbonates (pDTEC)...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534282/template-free-synthesis-of-phosphate-based-spheres-via-modified-supersaturated-phosphate-buffer-solutions
#9
Tao Qin, Yuanyuan Han, Peng Zhang, Ishtiaq Hassan Wani, Fredrik Nikolajeff, Klaus Leifer, Håkan Engqvist
Modified supersaturated phosphate buffer solutions were used to synthesize phosphate-based spheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). A series of ions concentrations in the modified phosphate buffer solutions were investigated in order to study their effects in precipitates morphologies. During synthesis, it was found that magnesium was the key factor in sphere formation. The morphologies of calcium phosphate, strontium phosphate and barium phosphate precipitates varied as the concentration of magnesium ions varied...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28526954/preface
#10
EDITORIAL
Gabriela Voskerician, Maria Siemionow
No abstract text is available yet for this article.
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28510114/fabricating-poly-1-8-octanediol-citrate-elastomer-based-fibrous-mats-via-electrospinning-for-soft-tissue-engineering-scaffold
#11
Lei Zhu, Yuanzheng Zhang, Yali Ji
Poly(1,8-octanediol citrate) (POC) is a recently developed biodegradable crosslinked elastomer that possesses good cytocompatibility and matchable mechanical properties to soft tissues. However, the thermosetting characteristic reveals a big challenge to manufacture its porous scaffold. Herein, POC elastomer was electrospun into fiber mat using poly(L-lactic acid) (PLLA) as a spinnable carrier. The obtained POC/PLLA fiber mats were characterized by scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), uniaxial tensile test, static-water-contact-angle, thermal analysis, in vitro degradation and biocompatibility test...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28508951/magnesium-ions-enhance-infiltration-of-osteoblasts-in-scaffolds-via-increasing-cell-motility
#12
Ki-Jung Kim, Sunkyung Choi, Yong Sang Cho, Seok-Jo Yang, Young-Sam Cho, Kee K Kim
Magnesium (Mg) ions are the most abundant intracellular divalent cations and play a pivotal role in numerous cellular processes. Biodegradable Mg-containing materials, including scaffolds, are promising candidates for orthopedic applications. Here, we investigated the effect of Mg ions on the cellular properties of osteoblasts. Cytotoxicity tests on osteoblasts confirmed that no cytotoxic effects were found up to a supplementing Mg ion concentration of 10 mM. Mg ions at a concentration of 5 mM increased the migration and invasiveness of osteoblasts...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28502026/dentin-remineralizing-ability-and-enhanced-antibacterial-activity-of-strontium-and-hydroxyl-ion-co-releasing-radiopaque-hydroxyapatite-cement
#13
R Jayasree, T S Sampath Kumar, S Mahalaxmi, Sireesha Abburi, Y Rubaiya, Mukesh Doble
Dental caries is an infection of the mineralized tooth structures that advances when acid secreted by bacterial action on dietary carbohydrates diffuses and dissolves the tooth mineral leading to demineralization. During treatment, clinicians often remove only the superficial infected tooth structures and retain a part of affected carious dentin to prevent excessive dentin loss and pulp exposure. Calcium hydroxide is used to treat the affected dentin because it is alkaline, induces pulp-dentin remineralization and decreases bacterial infection...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28500409/physicochemical-and-biological-characteristics-of-bmp-2-igf-1-loaded-three-dimensional-coaxial-electrospun-fibrous-membranes-for-bone-defect-repair
#14
Lihua Yin, Shaohua Yang, Miaomiao He, Yuchen Chang, Kaijuan Wang, Yidan Zhu, Yuhui Liu, Yaoren Chang, Zhanhai Yu
Coaxial electrospun fibrous membranes show favorable mechanical properties for use in guided bone regeneration (GBR). We used coaxial electrospinning technology to fabricate three-dimensional nanofiber membranes loaded with BMP-2 and IGF-1, and assessed the physicochemical and biological properties of these novel membranes in vitro. We fabricated four experimental groups of BMP-2/IGF-1/BSA-loaded membranes with different flow ratios (shell/core). Membrane characteristics were assessed by scanning and transmission electron microscopy, and laser confocal microscopy...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28497362/size-and-shape-dependent-cytotoxicity-profile-of-gold-nanoparticles-for-biomedical-applications
#15
Anna Woźniak, Anna Malankowska, Grzegorz Nowaczyk, Bartosz F Grześkowiak, Karol Tuśnio, Ryszard Słomski, Adriana Zaleska-Medynska, Stefan Jurga
Metallic nanoparticles, in particular gold nanoparticles (AuNPs), offer a wide spectrum of applications in biomedicine. A crucial issue is their cytotoxicity, which depends greatly on various factors, including morphology of nanoparticles. Because metallic nanoparticles have an effect on cell membrane integrity, their shape and size may affect the viability of cells, due to their different geometries as well as physical and chemical interactions with cell membranes. Variations in the size and shape of gold nanoparticles may indicate particular nanoparticle morphologies that provide strong cytotoxicity effects...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28497361/design-and-characterization-of-lisinopril-loaded-superparamagnetic-nanoparticles-as-a-new-contrast-agent-for-in-vitro-in-vivo-mri-imaging-diagnose-the-tumors-and-drug-delivery-system
#16
Sajjad Abbasi Pour, Hamid Reza Shaterian
Superparamagnetic γ-Fe2O3@SiO2@lisinopril (MNPs-Lisinopril) nanoparticles are T2 and T2* negative contrast agents for magnetic resonance imaging. In this work, we report the preparation of lisinopril-coated MNPs for the first time as new T2 and T2* negative contrast agent for in vitro and in vivo MRI imaging and demonstrate the potential it simultaneously for drug delivery system, diagnose the tumors and MRI contrast agent. Measurements on the relaxivities (r1, r2 and r2*) of the MNPs-Lisinopril were determined in deionized water (in vitro)...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28488039/development-of-antimicrobial-coating-by-later-by-layer-dip-coating-of-chlorhexidine-loaded-micelles
#17
Supreeda Tambunlertchai, Siriwan Srisang, Norased Nasongkla
Layer-by-layer (LbL) dip coating, accompanying with the use of micelle structure, allows hydrophobic molecules to be coated on medical devices' surface via hydrogen bonding interaction. In addition, micelle structure also allows control release of encapsulated compound. In this research, we investigated methods to coat and maximize the amount of chlorhexidine (CHX) on silicone surface through LbL dip coating method utilizing hydrogen bonding interaction between PEG on micelle corona and PAA. The number of coated cycles was varied in the process and 90 coating cycles provided the maximum amount of CHX loaded onto the surface...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28484926/effect-of-strontium-substitution-on-the-cytocompatibility-and-3-d-scaffold-structure-for-the-xsro-10-x-mgo-60sio2-20cao-10-p2o5-2%C3%A2-%C3%A2-%C3%A2-x%C3%A2-%C3%A2-%C3%A2-8-sol-gel-glasses
#18
Swati Thakur, Shikha Garg, Gurbinder Kaur, Om Prakash Pandey
In the present study, novel glasses xSrO-(10-x) MgO-60SiO2-20CaO-10 P2O5 (2 ≤ x ≤ 8, in steps of 2) are synthesized via sol-gel method. The current work focusses on the evaluation of mechanical, physical and biocompatible properties for sol-gel glasses. The pore size and surface area of these glasses were studied using BET analysis. The structural aspect of the glasses/glass ceramics was studied by XRD and Raman spectroscopy. The cytotoxicity assays were conducted for MG63 human osteosarcoma cell line...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28470446/drug-loaded-microbeads-entrapped-electrospun-mat-for-wound-dressing-application
#19
P Sneha Sundaran, Aswathy Bhaskaran, Sherrin T Alex, Tilak Prasad, V H Haritha, Y Anie, T V Kumary, P R Anil Kumar
A new design of antibiotic loaded wound dressing and its initial in vitro evaluation is described. Chitosan microbeads loaded with ampicillin were sandwiched within polycaprolactone electrospun mat (MbAPPCL). The morphology was analyzed by scanning electron microscopy and surface chemistry was characterized by Fourier Transform Infrared Spectroscopy. In vitro cytotoxicity using L-929 fibroblast cells by direct contact test and elution assay revealed non-cytotoxic nature of MbAPPCL. The cell adhesion and viability analysis further confirmed the cytocompatibility of MbAPPCL as a wound dressing material...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28470445/ftir-microscopy-contribution-for-comprehension-of-degradation-mechanisms-in-pla-based-implantable-medical-devices
#20
Adrien Leroy, Sofia Ribeiro, Carole Grossiord, Antoine Alves, Robert H Vestberg, Vincent Salles, Céline Brunon, Kerstin Gritsch, Brigitte Grosgogeat, Yves Bayon
The integration and evolution of implantable medical devices made of bioresorbable polymers and used for temporary biomedical applications are crucial criteria in the success of a therapy and means of follow-up after implantation are needed. The objective of this work is to develop and evaluate a method based on microscopic Fourier Transform InfraRed spectroscopy (FTIR) mappings to monitor the degradation of such polymers on tissue explant sections, after implantation. This technique provided information on their location and on both their composition and crystallinity, which is directly linked to their state of degradation induced predominantly by chain scissions...
June 2017: Journal of Materials Science. Materials in Medicine
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