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Journal of Materials Science. Materials in Medicine

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https://www.readbyqxmd.com/read/28631013/in-vivo-evaluation-of-the-bone-integration-of-coated-poly-vinyl-alcohol-hydrogel-fiber-implants
#1
David Moreau, Arthur Villain, Manon Bachy, Henry Proudhon, David N Ku, Didier Hannouche, Hervé Petite, Laurent Corté
Recently, it has been shown that constructs of poly(vinyl alcohol) (PVA) hydrogel fibers reproduce closely the tensile behavior of ligaments. However, the biological response to these systems has not been explored yet. Here, we report the first in vivo evaluation of these implants and focus on the integration in bone, using a rabbit model of bone tunnel healing. Implants consisted in bundles of PVA hydrogel fibers embedded in a PVA hydrogel matrix. Half of the samples were coated with a composite coating of hydroxyapatite (HA) particles embedded in PVA hydrogel...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28625001/nanostructured-sba-15-host-applied-in-ketorolac-tromethamine-release-system
#2
Jorgelina Cussa, Juliana M Juárez, Marcos B Gómez Costa, Oscar A Anunziata
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28620829/appearance-of-cell-adhesion-factor-in-osteoblast-proliferation-and-differentiation-of-apatite-coating-titanium-by-blast-coating-method
#3
Hirotsugu Umeda, Takamitsu Mano, Koji Harada, Ferdous Tarannum, Yoshiya Ueyama
We have already reported that the apatite coating of titanium by the blast coating (BC) method could show a higher rate of bone contact from the early stages in vivo, when compared to the pure titanium (Ti) and the apatite coating of titanium by the flame spraying (FS) method. However, the detailed mechanism by which BC resulted in satisfactory bone contact is still unknown. In the present study, we investigated the importance of various factors including cell adhesion factor in osteoblast proliferation and differentiation that could affect the osteoconductivity of the BC disks...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28616826/deposition-of-crystalline-hydroxyapatite-nano-particle-on-zirconia-ceramic-a-potential-solution-for-the-poor-bonding-characteristic-of-zirconia-ceramics-to-resin-cement
#4
Abbas Azari, Sakineh Nikzad, Arash Yazdani, Faezeh Atri, Abbas Fazel Anvari-Yazdi
The poor bonding strength of zirconia to different dental substrates is one of the challenging issues in restorative dentistry. Hydroxyapatite is an excellent biocompatible material with fine bonding properties. In this study, it was hypothesized that hydroxyapatite coating on zirconia would improve its bond strength. Forty-five zirconia blocks were prepared and randomly divided into three groups: hydroxyapatite coating, sandblasting, and no preparation (control). The blocks were bonded to cement and the micro-shear bond strength was measured following load application...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28589526/a-large-inner-diameter-multi-walled-carbon-nanotube-based-dual-drug-delivery-system-with-ph-sensitive-release-properties
#5
Tao Yang, Zhenzhen Wu, Pingting Wang, Tingting Mu, Han Qin, Zhimin Zhu, Jian Wang, Lei Sui
A novel dual-drug delivery system (DDDS) for cancer chemotherapy has been established by employing highly purified and mildly oxidized large-inner-diameter multi-walled carbon nanotubes (LID-MWCNTs) as the vector. The LID-MWCNTs were modified with the antitumor drugs, cisplatin (CDDP) and doxorubicin (DOX). CDDP was encapsulated inside the nanotube vectors by a wet-chemical approach while DOX was attached to the external surfaces through non-covalently interaction. The loading efficiencies of CDDP and DOX were as high as 84...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28540582/novel-synthesis-and-characterization-of-pristine-cu-nanoparticles-for-the-non-enzymatic-glucose-biosensor
#6
T Dayakar, K Venkateswara Rao, K Bikshalu, V Rajendar, Si-Hyun Park
Non enzymatic electrochemical glucose sensing was developed based on pristine Cu Nanopartilces (NPs)/Glassy Carbon Electrode (GCE) which can be accomplished by simple green method via ocimum tenuiflorum leaf extract. Then, the affect of leaf extract addition on improving Structural, Optical and electrochemical properties of pristine cu NPs was investigated. The synthesized Cu NPs were characterized with X-ray diffraction (X-ray), Uv-Visible spectroscopy (Uv-Vis), Fourier transformation infrared spectroscopy (FTIR), Particle size distribution (PSA), Scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDS), Transmission electron microscopy (TEM) for structural optical and morphological studies respectively...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28540581/streptococcus-mutans-adherence-and-biofilm-formation-on-experimental-composites-containing-dicalcium-phosphate-dihydrate-nanoparticles
#7
Andrei C Ionescu, Sebastian Hahnel, Gloria Cazzaniga, Marco Ottobelli, Roberto Ruggiero Braga, Marcela Charantola Rodrigues, Eugenio Brambilla
This study aimed at evaluating bacterial adhesion and biofilm formation on resin-based composites (RBC) including dicalcium phosphate dihydrate nanoparticles (nDCPD). METHODS: Specimens were prepared from experimental RBCs with BisGMA/TEGDMA resin matrix including 20 vol% of either nDCPD (nDCPD-RBC), TEGDMA-functionalized nDPCD (F-nDCPD-RBC) or silanized silica (SiO2-RBC). Neat resin blend (control-Resin), conventional nanohybrid RBC (control-RBC) and human enamel were used for reference...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534290/wear-predictions-for-uhmwpe-material-with-various-surface-properties-used-on-the-femoral-component-in-total-knee-arthroplasty-a-computational-simulation-study
#8
Kyoung-Tak Kang, Juhyun Son, Ho-Joong Kim, Changhyun Baek, Oh-Ryong Kwon, Yong-Gon Koh
The wear of ultrahigh-molecular weight polyethylene (UHMWPE) tibial inserts in total knee arthroplasty (TKA) remains a major limitation that hinders the longevity of clinically successful devices. Surface properties significantly affect the overall performance of TKA, and surface modification with mechanically and chemically stable materials is an effective method for overcoming the wear of TKA. However, wear tests are not cost-efficient or time-efficient; thus, the effects of geometric, loading, and alignment perturbations are often evaluated via parametric studies...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534289/exposure-of-articular-chondrocytes-to-wear-particles-induces-phagocytosis-differential-inflammatory-gene-expression-and-reduced-proliferation
#9
Michael D Kurdziel, Meagan Salisbury, Lige Kaplan, Tristan Maerz, Kevin C Baker
The production of wear debris particulate remains a concern due to its association with implant failure through complex biologic interactions. In the setting of unicompartmental knee arthroplasty (UKA), damage and wear of the components may introduce debris particulate into the adjacent, otherwise, healthy compartment. The purpose of this study was to investigate the in vitro effect of polymeric and metallic wear debris particles on cell proliferation, extracellular matrix regulation, and phagocytosis index of normal human articular chondrocytes (nHACs)...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534288/physicochemical-and-biological-characterization-of-sustained-isopropyl-unoprostone-release-device-made-of-poly-ethyleneglycol-dimethacrylates
#10
Nobuhiro Nagai, Yasuko Izumida, Yoshimasa Yamazaki, Hirokazu Kaji, Junichi Kawasaki, Matsuhiko Nishizawa, Toshiaki Abe
Transscleral drug delivery is becoming increasingly popular to manage posterior eye diseases. To evaluate the clinical application of a transscleral, sustained, unoprostone (UNO)-release device (URD) constructed of photopolymerized tri(ethyleneglycol) dimethacrylate and poly(ethyleneglycol) dimethacrylate, we evaluated physicochemical and biological properties of this device. The URD consists of a drug-impermeable reservoir and a semi-permeable cover. The in vitro release rate of UNO from the URD increased with increasing temperatures from 20 to 45 °C...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534287/loading-with-vancomycin-does-not-decrease-gentamicin-elution-in-gentamicin-premixed-bone-cement
#11
Sebastian P Boelch, Martin C Jordan, Joerg Arnholdt, Maximilian Rudert, Martin Luedemann, Andre F Steinert
Antibiotic loaded bone cements are used as drug delivery systems for the treatment of periprosthetic joint infections. They can be loaded with antibiotics during industrial component production (premixing) and during cement preparation (manually blending). Although double premixed antibiotic loaded bone cements are available, manually blending of a gentamicin premixed antibiotic loaded bone cement with vancomycin is still popular. We compared in vitro antibiotic elution and compressive strength of 0.5 g gentamicin premixed bone cement (PALACOS® R + G), 0...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534286/development-of-a-novel-resin-based-dental-material-with-dual-biocidal-modes-and-sustained-release-of-ag-ions-based-on-photocurable-core-shell-agbr-cationic-polymer-nanocomposites
#12
Weiwei Cao, Yu Zhang, Xi Wang, Yinyan Chen, Qiang Li, Xiaodong Xing, Yuhong Xiao, Xuefeng Peng, Zhiwen Ye
Research on the incorporation of cutting-edge nano-antibacterial agent for designing dental materials with potent and long-lasting antibacterial property is demanding and provoking work. In this study, a novel resin-based dental material containing photocurable core-shell AgBr/cationic polymer nanocomposite (AgBr/BHPVP) was designed and developed. The shell of polymerizable cationic polymer not only provided non-releasing antibacterial capability for dental resins, but also had the potential to polymerize with other methacrylate monomers and prevented nanoparticles from aggregating in the resin matrix...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534285/development-of-self-forming-doxorubicin-loaded-polymeric-depots-as-an-injectable-drug-delivery-system-for-liver-cancer-chemotherapy
#13
Pinunta Nittayacharn, Norased Nasongkla
The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy and studied the release profiles of doxorubicin (Dox) from different depot formulations. Tri-block copolymers of poly(ε-caprolactone), poly(D,L-lactide) and poly(ethylene glycol) named PLECs were successfully used as a biodegradable material to encapsulate Dox as the injectable local drug delivery system. Depot formation and encapsulation efficiency of these depots were evaluated...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534284/transparent-bactericidal-zno-nanocoatings
#14
S K Evstropiev, K V Dukelskii, A V Karavaeva, V N Vasilyev, E V Kolobkova, N V Nikonorov, K S Evstropyev
Thin bactericidal ZnO coatings prepared with the polymer-salt method are shown to be highly transparent in the visible. The spectral measurements and XRD analysis data show that coatings prepared are formed by ZnO nanoparticles ~ 10 nm in size. The coatings demonstrate the bactericidal effect against the gram-positive Staphylococcus aureus ATCC 209P and gram-negative Escherichia coli ATCC 25922 bacteria both under the natural light and in the darkness.
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534283/cell-type-specific-extracellular-matrix-guided-the-differentiation-of-human-mesenchymal-stem-cells-in-3d-polymeric-scaffolds
#15
Yong Mao, Tyler Hoffman, Amy Wu, Ritu Goyal, Joachim Kohn
The tissue microenvironment has profound effects on tissue-specific regeneration. The 3-dimensional extracellular matrix (ECM) niche influences the linage-specific differentiation of stem cells in tissue. To understand how ECM guides tissue-specific regeneration, we established a series of 3D composite scaffolds containing ECMs derived from different primary cells isolated from a single animal species and assessed their impact on the differentiation of human mesenchymal stem cells (hMSCs). Synthetic microfiber scaffolds (fiber mats) were fabricated by electrospinning tyrosine-derived polycarbonates (pDTEC)...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28534282/template-free-synthesis-of-phosphate-based-spheres-via-modified-supersaturated-phosphate-buffer-solutions
#16
Tao Qin, Yuanyuan Han, Peng Zhang, Ishtiaq Hassan Wani, Fredrik Nikolajeff, Klaus Leifer, Håkan Engqvist
Modified supersaturated phosphate buffer solutions were used to synthesize phosphate-based spheres, including calcium phosphate (CaP), strontium phosphate (SrP) and barium phosphate (BaP). A series of ions concentrations in the modified phosphate buffer solutions were investigated in order to study their effects in precipitates morphologies. During synthesis, it was found that magnesium was the key factor in sphere formation. The morphologies of calcium phosphate, strontium phosphate and barium phosphate precipitates varied as the concentration of magnesium ions varied...
July 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28560581/antimicrobial-and-anti-biofilm-properties-of-polypropylene-meshes-coated-with-metal-containing-dlc-thin-films
#17
Elisa M Cazalini, Walter Miyakawa, Guilherme R Teodoro, Argemiro S S Sobrinho, José E Matieli, Marcos Massi, Cristiane Y Koga-Ito
A promising strategy to reduce nosocomial infections related to prosthetic meshes is the prevention of microbial colonization. To this aim, prosthetic meshes coated with antimicrobial thin films are proposed. Commercial polypropylene meshes were coated with metal-containing diamond-like carbon (Me-DLC) thin films by the magnetron sputtering technique. Several dissimilar metals (silver, cobalt, indium, tungsten, tin, aluminum, chromium, zinc, manganese, tantalum, and titanium) were tested and compositional analyses of each Me-DLC were performed by Rutherford backscattering spectrometry...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28526954/preface
#18
EDITORIAL
Gabriela Voskerician, Maria Siemionow
No abstract text is available yet for this article.
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28510114/fabricating-poly-1-8-octanediol-citrate-elastomer-based-fibrous-mats-via-electrospinning-for-soft-tissue-engineering-scaffold
#19
Lei Zhu, Yuanzheng Zhang, Yali Ji
Poly(1,8-octanediol citrate) (POC) is a recently developed biodegradable crosslinked elastomer that possesses good cytocompatibility and matchable mechanical properties to soft tissues. However, the thermosetting characteristic reveals a big challenge to manufacture its porous scaffold. Herein, POC elastomer was electrospun into fiber mat using poly(L-lactic acid) (PLLA) as a spinnable carrier. The obtained POC/PLLA fiber mats were characterized by scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), uniaxial tensile test, static-water-contact-angle, thermal analysis, in vitro degradation and biocompatibility test...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28508951/magnesium-ions-enhance-infiltration-of-osteoblasts-in-scaffolds-via-increasing-cell-motility
#20
Ki-Jung Kim, Sunkyung Choi, Yong Sang Cho, Seok-Jo Yang, Young-Sam Cho, Kee K Kim
Magnesium (Mg) ions are the most abundant intracellular divalent cations and play a pivotal role in numerous cellular processes. Biodegradable Mg-containing materials, including scaffolds, are promising candidates for orthopedic applications. Here, we investigated the effect of Mg ions on the cellular properties of osteoblasts. Cytotoxicity tests on osteoblasts confirmed that no cytotoxic effects were found up to a supplementing Mg ion concentration of 10 mM. Mg ions at a concentration of 5 mM increased the migration and invasiveness of osteoblasts...
June 2017: Journal of Materials Science. Materials in Medicine
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