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Journal of Materials Science. Materials in Medicine

Milou Groot Nibbelink, Katarzyna Skrzypek, Lisanne Karbaat, Sanne Both, Jacqueline Plass, Bettie Klomphaar, Jéré van Lente, Sieger Henke, Marcel Karperien, Dimitrios Stamatialis, Aart van Apeldoorn
Extrahepatic transplantation of islets of Langerhans could aid in better survival of islets after transplantation. When islets are transfused into the liver 60-70% of them are lost immediately after transplantation. An important factor for a successful extrahepatic transplantation is a well-vascularized tissue surrounding the implant. There are many strategies known for enhancing vessel formation such as adding cells with endothelial potential, the combination with angiogenic factors and / or applying surface topography at the exposed surface of the device...
November 9, 2018: Journal of Materials Science. Materials in Medicine
Adel Badria, Petros Koutsoukos, Sotirios Korossis, Dimosthenis Mavrilas
Heart valve diseases remain common in industrialized countries. Bioprosthetic heart valves, introduced as free of anticoagulation therapy alternatives to mechanical substitutes. Still they suffer from long term failure due to calcification. Different treatment methods introduced to inhibit calcification, have so far been limited in success. Glycosaminoglycans (GAGs) possess properties including high negative charge, anticoagulation and anti-inflammatory activity that make them a potential solution for calcification problem...
November 9, 2018: Journal of Materials Science. Materials in Medicine
Leila Moradkhannejhad, Majid Abdouss, Nasser Nikfarjam, Saedeh Mazinani, Vahid Heydari
In this work, for the first time, zein nanofiber mats loaded with ethanol extracts propolis (EEP) were successfully produced. Raw propolis was extracted by ethanol 70% and total flavonoid content was estimated by aluminum chloride colorimetric method. The anti-microbial activity of the EEP was investigated and compared with amoxicillin via zone of inhibition test against various microorganisms included gram-positive: Staphylococcus aureus, Staphylococcus epidermidis, gram-negative: Escherichia coli, Salmonella enterica, Pseudomonas aeruginosa and fungus: Candida albicans...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Javi Vilarrasa, Luis M Delgado, Marta Galofré, Gerard Àlvarez, Deborah Violant, José María Manero, Vanessa Blanc, F Javier Gil, José Nart
Peri-implantitis is an infectious disease that affects the supporting soft and hard tissues around dental implants and its prevalence is increasing considerably. The development of antibacterial strategies, such as titanium antibacterial-coated surfaces, may be a promising strategy to prevent the onset and progression of peri-implantitis. The aim of this study was to quantify the biofilm adhesion and bacterial cell viability over titanium disc with or without antibacterial surface treatment. Five bacterial strains were used to develop a multispecies oral biofilm...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Alessandro Gavazzoni, Liogi Iwaki Filho, Luzmarina Hernandes
Guided Bone Regeneration (GBR) is a technique based on the use of a physical barrier that isolates the region of bone regeneration from adjacent tissues. The objective of this study was to compare GBR, adopting a critical-size defect model in rat calvaria and using collagen membrane separately combined with two filling materials, each having different resorption rates. A circular defect 8 mm in diameter was made in the calvaria of Wistar rats. The defects were then filled with calcium sulfate (CaS group) or deproteinized bovine bone mineral (DBBM group) and covered by resorbable collagen membrane...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Jian Cao, Haifeng Niu, Jiang Du, Lili Yang, Maobin Wei, Xiaoyan Liu, Qianyu Liu, Jinghai Yang
ZnS:Mn2+ quantum dots (QDs) Fe3 O4 QDs/SiO2 /P(NIPAAm-co-AAm) core-shell-shell nanocomposites have been successfully fabricated by free radical polymerization method. The average diameter and LCST of ZnS:Mn2+ QDs Fe3 O4 QDs/SiO2 /P(NIPAAm-co-AAm) (NIPAAm:AAm=90:10) nanocomposites was about 200 nm and 41.1°. It possessed a strong yellow-orange emission peak centered at 589 nm from the Mn2+ 4 T1 -6 A1 transition and the desired superparamagnetic property at room temperature. The DOX encapsulation efficiency and loading capacity was 88% and 15...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Nidhi P Parikh, Kinnari H Parekh
We present here a modulating effect on lysozyme derived Amyloid β fibrils by aqueous magnetic fluid. This non-conventional approach of treatment of lysozyme derived Amyloid β fibrils showed lysing of Amyloid fibrils to its secondary structures which can be seen using optical microscope and scanning electron microscopic image. The size of lysozyme derived amyloid fibrils before and after treatment was measured using dynamic light scattering technique. The mechanism of defragmentation of lysozyme derived Amyloid β fibrils by magnetic fluid is explained...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Sarah Oliveira Lamas de Souza, Maria Carolina Andrade Guerra, Luiz Guilherme Dias Heneine, Carolina Reis de Oliveira, Armando da Silva Cunha Junior, Sílvia Ligório Fialho, Rodrigo Lambert Oréfice
Age-related macular degeneration (AMD) is a degenerative ocular disease that affects the central retina. It is considered the main cause of blindness and loss of vision worldwide. Angiogenic factors are associated with AMD, which has led to the use of antiangiogenic drugs, such as bevacizumab, to treat the disease using frequent intravitreal injections. In the present study, biodegradable core shell nanofibers containing bevacizumab were prepared by the coaxial electrospinning technique. It is thought that the shell could control the release of the drug, while the core would protect and store the drug...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Niloofar Nazeri, Mohammad Ali Derakhshan, Reza Faridi-Majidi, Hossein Ghanbari
Electro-conductive nanocomposites have several applications in biomedical field. Development of a biocompatible electro-conductive polymeric materials is therefore of prime importance. In this study, electro-conductive nanofibrous mats of PLGA/CNT were fabricated through different methods including blend electrospinning, simultaneous PLGA electrospinning and CNT electrospraying and ultrasound-induced adsorption of CNTs on the electrospun PLGA nanofibers. The morphology and diameter of fibers were characterized by SEM and TEM, showing the lowest average diameters of 477 ± 136 nm for PLGA/MWCNT blend nanocomposites...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Robin Augustine, Anwarul Hasan, V K Yadu Nath, Jince Thomas, Anitha Augustine, Nandakumar Kalarikkal, Ala-Eddin Al Moustafa, Sabu Thomas
Electrospun membranes have the potential to act as an effective barrier for wounds from the external environment to prevent pathogens. In addition, materials with good antibacterial properties can effectively fight off the invading pathogens. In this paper, we report the development of a novel electrospun polyvinyl alcohol (PVA) membrane containing biosynthesized silver nanoparticle (bAg) for wound dressing applications. Plant extract from a medicinal plant Mimosa pudica was utilized for the synthesis of bAg...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Jennifer C Ashworth, Marco Mehr, Paul G Buxton, Serena M Best, Ruth E Cameron
Design of cell-free scaffolds for endogenous cell recruitment requires an intimate knowledge of precise relationships between structure and biological function. Here, we use morphological analysis by Micro-CT to identify the key structural features necessary for periodontal ligament fibroblast recruitment into collagen scaffolds. By the combined use of time-lapse imaging and end-point invasion analysis, we distinguish the influences of pore size, pore wall alignment, and pore transport pathways (percolation diameter) on the individual cell migration and bulk invasion characteristics of these fibroblasts...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Behnaz Banimohammad Shotorbani, Helder André, Abolfazl Barzegar, Nosratollah Zarghami, Roya Salehi, Effat Alizadeh
Cell sheet technology aims at replacement of artificial extracellular matrix (ECM) or scaffolds, popular in tissue engineering, with natural cell derived ECM. Adipose tissue mesenchymal stem cells (ASCs) have the ability of ECM secretion and presented promising outcomes in clinical trials. As well, different studies found that secretome of ASCs could be suitable for triggering cell free regeneration induction. The aim of this study was to investigate the effect of using two bio-factors: secretome of ASCs (SE) and vitamin C (VC) for cell sheet engineering on a thermosensitive poly N-isopropyl acryl amide-Methacrylic acid (P(NIPAAm-MAA)) hydrogel...
November 3, 2018: Journal of Materials Science. Materials in Medicine
L Grefen, F König, M Grab, C Hagl, N Thierfelder
Pericardial tissue is widely used as a biomaterial, especially for cardiovascular application. Tissue processing plays a key role in developing future scaffolds derived from biological material, yet standardized evaluation is still pending. This study presents a comprehensive assessment of different treatment protocols of bovine pericardium and compares those findings to commercially available decellularized bovine (CAB) and equine (CAE) pericardial patches. Native samples were fixed with glutaraldehyde (GA) or decellularized...
November 3, 2018: Journal of Materials Science. Materials in Medicine
Weiwei Cao, Yu Zhang, Xi Wang, Qiang Li, Yuhong Xiao, Peili Li, Lina Wang, Zhiwen Ye, Xiaodong Xing
There is an increasing clinical need to design dental restorative materials that combine excellent mechanical property and anti-biofilm activity. In the current study, photocurable polycation functionalized nanodiamond (QND) was synthesized and proposed as novel filler for dental resins. By reason of increased repulsive force between nanoparticles and enhanced compatibility with resin matrix, QND dispersed uniformly in reinforced resins, which would help to transfer stress and deformation from the matrix to fillers more efficiently, resulting in a significant improvement in mechanical properties...
October 24, 2018: Journal of Materials Science. Materials in Medicine
Guido A Zapata-Catzin, Marcos Bonilla-Hernández, Rossana F Vargas-Coronado, José M Cervantes-Uc, Humberto Vázquez-Torres, Efrén Hernandez-Baltazar, Lerma H Chan-Chan, Assunta Borzacchiello, Juan V Cauich-Rodríguez
Segmented polyurethanes were prepared with polycaprolactone diol as soft segment and various amounts of 4,4´-Methylenebis(cyclohexyl isocyanate) and atorvastatin, a statin used for lowering cholesterol, in order to obtain SPU with different content of rigid segments. Polyurethanes with 35% or 50% of rigid segment content were physicochemically characterized and their biocompatibility assessed with L929 fibroblasts. High concentrations of atorvastatin were incorporated by increasing the content of rigid segments as shown by FTIR, Raman, NMR, XPS and EDX...
October 24, 2018: Journal of Materials Science. Materials in Medicine
Peng Liu, Yansha Hao, Yao Ding, Zhang Yuan, Yisi Liu, Kaiyong Cai
In this study, a type of bacteria enzyme-triggered antibacterial surface with a controlled release of Ag ions was developed. Firstly, chitosan-silver nanocomposites (Chi@Ag NPs) were in situ synthesized via using ascorbic acid as reducing agent. Chi@Ag NPs were characterized by transmission electron microscopy, ultraviolet-visible spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy. Subsequently, Chi@Ag NPs and hyaluronic acid (HA) were used to fabricate antibacterial composite coating via Layer-by-Layer (LBL) self-assembly method...
October 22, 2018: Journal of Materials Science. Materials in Medicine
Mario Lescan, Abdulwahab Al-Saidi, Bernd Neumann, Tim-Oliver Greiner, Tobias Walker, Helmut Hierlemann, Christoph Brochhausen, Heinrich Planck, Hans-Peter Wendel, Christian Schlensak, Henning Lausberg
No abstract text is available yet for this article.
October 22, 2018: Journal of Materials Science. Materials in Medicine
Mehdi Razavi, Mohammadhossein Fathi, Omid Savabi, Lobat Tayebi, Daryoosh Vashaee
Magnesium (Mg) alloys as a new group of biodegradable metal implants are being extensively investigated as a promising selection for biomaterials applications due to their apt mechanical and biological performance. However, as a foremost drawback of Mg alloys, the high degradation in body fluid prevents its clinical applications. In this work, a bioceramic composite coating is developed composed of diopside, bredigite, and fluoridated hydroxyapatite on the AZ91 Mg alloy in order to moderate the degradation rate, while improving its bioactivity, cell compatibility, and mechanical integrity...
October 22, 2018: Journal of Materials Science. Materials in Medicine
Esmat Jalalvandi, Amin Shavandi
One of the important routes of drug administration for localized delivery of contraceptives and cervical cancer treatment agents is vaginal canal. Due to the low pH of vagina, a pH-responsive drug delivery system was developed. This hydrogel was synthesized based on a mucoadhesive biopolymer, chitosan (CS), that promotes the interaction between the hydrogel and mucosal surface of the vagina, potentially increasing the residence time of the system. This injectable hydrogel was formed via acid-labile Schiff-base linkages between free amine groups and aldehyde functionalities on modified chitosan...
October 22, 2018: Journal of Materials Science. Materials in Medicine
Hanna Pihlman, Pauli Keränen, Kaarlo Paakinaho, Jere Linden, Markus Hannula, Iida-Kaisa Manninen, Jari Hyttinen, Mikko Manninen, Outi Laitinen-Vapaavuori
The advantages of synthetic bone graft substitutes over autogenous bone grafts include abundant graft volume, lack of complications related to the graft harvesting, and shorter operation and recovery times for the patient. We studied a new synthetic supercritical CO2 -processed porous composite scaffold of β-tricalcium phosphate and poly(L-lactide-co-caprolactone) copolymer as a bone graft substitute in a rabbit calvarial defect. Bilateral 12 mm diameter critical size calvarial defects were successfully created in 18 rabbits...
October 8, 2018: Journal of Materials Science. Materials in Medicine
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