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Journal of Materials Science. Materials in Medicine

Alexander M Tatara, Allison J Rozich, Panayiotis D Kontoyiannis, Emma Watson, Nathaniel D Albert, George N Bennett, Antonios G Mikos
While antibiotic-eluting polymethylmethacrylate space maintainers have shown efficacy in the treatment of bacterial periprosthetic joint infection and osteomyelitis, antifungal-eluting space maintainers are associated with greater limitations for treatment of fungal musculoskeletal infections including limited elution concentration and duration. In this study, we have designed a porous econazole-eluting space maintainer capable of greater inhibition of fungal growth than traditional solid space maintainers...
May 11, 2018: Journal of Materials Science. Materials in Medicine
Pei Wang, Ranjith Kumar Kankala, Jingqian Fan, Ruimin Long, Yuangang Liu, Shibin Wang
Recently, the layer-by-layer (LbL) self-assembly technology has attracted the enormous interest of researchers in synthesizing various pharmaceutical dosage forms. Herewith, we designed a biocompatible drug delivery system containing the calcium carbonate microparticles (CaCO3 MPs) that coated with the alternatively charged polyelectrolytes, i.e., poly-L-ornithine (PLO)/fucoidan by LbL self-assembly process (LbL MPs). Upon coating with the polyelectrolytes, the mean particle size of MPs obtained from SEM observations increased from 1...
May 10, 2018: Journal of Materials Science. Materials in Medicine
Sarah Oliveira Lamas Souza, Monique Alvarenga Pinto Cotrim, Rodrigo Lambert Oréfice, Suzana Gonçalves Carvalho, Jessyca Aparecida Paes Dutra, Francisco de Paula Careta, Juliana Alves Resende, Janaina Cecília Oliveira Villanova
Cooperation between researchers in the areas of medical, pharmaceutical and materials science has facilitated the development of pharmaceutical dosage forms that elicit therapeutic effects and protective action with a single product. In addition to optimizing pharmacologic action, such dosage forms provide greater patient comfort and increase success and treatment compliance. In the present work, we prepared semipermeable bioactive electrospun fibers for use as wound dressings containing silver sulfadiazine complexed with β-cyclodextrin in a poly(Ɛ-caprolactone) nanofiber matrix aiming to reduce the direct contact between silver and skin and to modulate the drug release...
May 10, 2018: Journal of Materials Science. Materials in Medicine
Bingbing Fan, Yaya Li, Fengqi Han, Tingting Su, Jingguo Li, Rui Zhang
The present paper represents a facile and rapid synthesis of silver-reduced graphene oxide Ag/rGO (Ag/reduced graphite oxides) composites with the help of microwave irradiation. This is a rapid green route requiring power microwave irradiation only 400 W(30 s) and 200 W (60 s) for the uniform Ag nanoparticles with average diameter of ~10 nm embedded on rGO sheets. In the microwave irradiation process, rGO samples absorb electromagnetic energy to be heated rapidly due to their intrinsic dielectric and conductive losses...
May 10, 2018: Journal of Materials Science. Materials in Medicine
Xiao Fu, Jian-Ping Ning
Anticoagulation therapy plays a vital role in the prevention of blood clot formation during hemodialysis and hemofiltration, especially for critical care patients. Here, we synthesized a novel argatroban (Arg)-modified polysulfone (PSf) membrane for anticoagulation. Arg was grafted onto the PSF membrane via chemical modification to increase membrane hydrophilicity. Protein adsorption, coagulation, as well as activation of platelets and complement systems were greatly reduced on the Arg-modified PSf membrane...
May 9, 2018: Journal of Materials Science. Materials in Medicine
Qaisar Nawaz, Muhammad Atiq Ur Rehman, Andreas Burkovski, Jochen Schmidt, Ana M Beltrán, Ameen Shahid, Nina K Alber, Wolfgang Peukert, Aldo R Boccaccini
Mesoporous bioactive glass (BG) nanoparticles based in the system: SiO2 -P2 O5 -CaO-MnO were synthesized via a modified Stöber process at various concentrations of Mn (0-7 mol %). The synthesized manganese-doped BG nanoparticles were characterized in terms of morphology, composition, in vitro bioactivity and antibacterial activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis confirmed that the particles had spherical morphology (mean particle size: 110 nm) with disordered mesoporous structure...
May 8, 2018: Journal of Materials Science. Materials in Medicine
Miguel Manzano, María Vallet-Regí
In the last few years mesoporous silica nanoparticles (MSNs) have gained the attention of the nanomedicine research community, especially for the potential treatment of cancer. Although this topic has been reviewed before, periodic updates on such a hot topic are necessary due to the dynamic character of this field. The reasons that make MSNs so attractive for designing controlled drug delivery systems lie beneath their physico-chemical stability, easy functionalisation, low toxicity and their great loading capacity of many different types of therapeutic agents...
May 8, 2018: Journal of Materials Science. Materials in Medicine
M Meininger, S Meininger, J Groll, U Gbureck, C Moseke
Electrochemically assisted deposition of Ca(OH)2 (Portlandite) coatings on titanium surfaces has been proven as a promising method to provide the substrate with a most desirable combination of significant bacterial growth reduction on one hand and good biocompatibility on the other. Due to the rapid in vivo transformation of Ca(OH)2 to hydroxyapatite, the antimicrobial activity will be an ephemeral property of the coating when implanted into the human body. In this study, the ability to reduce bacterial growth of such portlandite coatings was significantly enhanced by an ionic modification with copper and silver ions...
May 7, 2018: Journal of Materials Science. Materials in Medicine
Carlos Mota, Mario Milazzo, Daniele Panetta, Luisa Trombi, Vera Gramigna, Piero A Salvadori, Stefano Giannotti, Luca Bruschini, Cesare Stefanini, Lorenzo Moroni, Stefano Berrettini, Serena Danti
The external auditory canal (EAC) is an osseocartilaginous structure extending from the auricle to the eardrum, which can be affected by congenital, inflammatory, and neoplastic diseases, thus reconstructive materials are needed. Current biomaterial-based approaches for the surgical reconstruction of EAC posterior wall still suffer from resorption (biological) and extrusion (synthetic). In this study, 3D fiber deposited scaffolds based on poly(ethylene oxide terephthalate)/poly(butylene terephthalate) were designed and fabricated to replace the EAC wall...
May 7, 2018: Journal of Materials Science. Materials in Medicine
Alessandra Soriente, Ines Fasolino, Maria Grazia Raucci, Christian Demitri, Marta Madaghiele, Antonella Giuri, Alessandro Sannino, Luigi Ambrosio
The present work is focused on the design of a bioactive chitosan-based scaffold functionalized with organic and inorganic signals to provide the biochemical cues for promoting stem cell osteogenic commitment. The first approach is based on the use of a sequence of 20 amino acids corresponding to a 68-87 sequence in knuckle epitope of BMP-2 that was coupled covalently to the carboxyl group of chitosan scaffold. Meanwhile, the second approach is based on the biomimetic treatment, which allows the formation of hydroxyapatite nuclei on the scaffold surface...
May 7, 2018: Journal of Materials Science. Materials in Medicine
Anders Palmquist
Osseointegrated implants are frequently used in reconstructive surgery, both in the dental and orthopedic field, restoring physical function and improving the quality of life for the patients. The bone anchorage is typically evaluated at micrometer resolution, while bone tissue is a dynamic composite material composed of nanoscale collagen fibrils and apatite crystals, with defined hierarchical levels at different length scales. In order to understand the bone formation and the ultrastructure of the interfacial tissue, analytical strategies needs to be implemented enabling multiscale and multimodal analyses of the intact interface...
May 7, 2018: Journal of Materials Science. Materials in Medicine
Anthie Georgopoulou, Fotios Papadogiannis, Aristea Batsali, John Marakis, Kalliopi Alpantaki, Aristides G Eliopoulos, Charalampos Pontikoglou, Maria Chatzinikolaidou
Chitosan/Gelatin (CS:Gel) scaffolds were fabricated by chemical crosslinking with glutaraldehyde or genipin by freeze drying. Both crosslinked CS:Gel scaffold types with a mass ratio of 40:60% form a gel-like structure with interconnected pores. Dynamic rheological measurements provided similar values for the storage modulus and the loss modulus of the CS:Gel scaffolds when crosslinked with the same concentration of glutaraldehyde vs. genipin. Compared to genipin, the glutaraldehyde-crosslinked scaffolds supported strong adhesion and infiltration of pre-osteoblasts within the pores as well as survival and proliferation of both MC3T3-E1 pre-osteoblastic cells after 7 days in culture, and human bone marrow mesenchymal stem cells (BM-MSCs) after 14 days in culture...
May 5, 2018: Journal of Materials Science. Materials in Medicine
Shu F Situ-Loewenstein, Sameera Wickramasinghe, Eric C Abenojar, Bernadette O Erokwu, Chris A Flask, Zhenghong Lee, Anna Cristina S Samia
Iron oxide nanoparticles (IONPs) with high-index facets have shown great potential as high performance T2 contrast agents for MRI. Previous synthetic approaches focused mainly on ion-directed or oxidative etching methods. Herein, we report a new synthetic route for preparing high-index faceted iron oxide concave nanocubes using a bulky coordinating solvent. Through the systematic replacement of a non-coordinating solvent, 1-octadecene, with trioctylamine, the solvent interaction with the nanoparticle surface is modified, thereby, promoting the growth evolution of the IONPs from spherical to concave cubic morphology...
May 5, 2018: Journal of Materials Science. Materials in Medicine
Nagat Areid, Ilkka Kangasniemi, Eva Söderling, Timo O Närhi
The purpose of this study was to evaluate blood and platelet response to nanostructured TiO2 coatings and to investigate the effect of Ultraviolet (UV) light treatment on blood clotting ability, platelet activation and protein adhesion. Ti-6Al-4V titanium alloy plates (n = 138) were divided into three groups; a sol-gel derived MetAliveTM coating (MA); hydrothermal coating (HT); and a non-coated group (NC). Sixty nine titanium substrates were further treated with UV light for 1 h. The thrombogenicity of the titanium substrates was assessed using fresh human blood with a whole blood kinetic clotting time method...
May 4, 2018: Journal of Materials Science. Materials in Medicine
S M Naga, M Sayed, H F El-Maghraby, M Awaad
The target of the recent study is to achieve a significant inexpensive and eco-friendly way for getting ZTA/HA composites, based on the nano-HA derived from the eggshell biogenic source. Combining simultaneously the porous structure; which is considered as a bone formation key, with developed mechanical properties and adequate biocompatibility, is another purpose of this study. Furthermore, the impact of ZTA addition from 10-30 mass-%, fabricated by uniaxial pressing and sintering at 1200-1300 °C for 2 h, on the physical and mechanical properties, microstructure and phase composition of ZTA/HA composite bodies was investigated...
May 4, 2018: Journal of Materials Science. Materials in Medicine
J Antons, M G M Marascio, J Nohava, R Martin, L A Applegate, P E Bourban, D P Pioletti
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0...
May 4, 2018: Journal of Materials Science. Materials in Medicine
Mehdi Razavi, Avnesh S Thakor
In this study, 3D macroporous bioscaffolds were developed from poly(dimethylsiloxane) (PDMS) which is inert, biocompatible, non-biodegradable, retrievable and easily manufactured at low cost. PDMS bioscaffolds were synthesized using a solvent casting and particulate leaching (SCPL) technique and exhibited a macroporous interconnected architecture with 86 ± 3% porosity and 300 ± 100 µm pore size. As PDMS intrinsically has a hydrophobic surface, mainly due to the existence of methyl groups, its surface was modified by oxygen plasma treatment which, in turn, enabled us to apply a novel polydopamine coating onto the surface of the bioscaffold...
May 3, 2018: Journal of Materials Science. Materials in Medicine
O Hasturk, M Ermis, U Demirci, N Hasirci, V Hasirci
Osteogenicity and osteointegration of materials is one of the key elements of the success of bone implants. Poly(methyl methacrylate) (PMMA) is the basic compound of bone cement and has been widely investigated for other orthopedic applications, but its poor osteointegration and the subsequent loosening of implant material limits its widespread use as bone implants. Micropillar features on substrate surfaces were recently reported to modulate cell behavior through alteration of cell morphology and promotion of osteogenesis...
May 2, 2018: Journal of Materials Science. Materials in Medicine
S M Londoño-Restrepo, R Jeronimo-Cruz, E Rubio-Rosas, M E Rodriguez-García
This paper focus on physicochemical changes in bio-hydroxyapatite (BIO-HAp) from bovine femur obtained by calcination at high temperatures: 520-620 (each 20 °C) at 7.4 °C/min and from 700 to 1100 °C (each 100 °C) at three heating rates: 7.4, 9.9, and 11.1 °C/min. BIO-HAp samples were obtained using a multi-step process: cleaning, milling, hydrothermal process, calcination in an air atmosphere, and cooling in furnace air. Inductively Couple Plasma (ICP) showed that the presence of Mg, K, S, Ba, Zn, and Na, is not affected by the annealing temperature and heating rate...
May 2, 2018: Journal of Materials Science. Materials in Medicine
A Irizar, M J B Amorim, K P Fuller, D I Zeugolis, J J Scott-Fordsmand
Poly-ε-caprolactone (PCL) based medical devices are increasingly produced and thus, their presence in the environment is likely to increase. The present study analysed the biodegradation of PCL electro-spun scaffolds (alone) and PCL electro-spun scaffolds coated with human recombinant (hR) collagen and Bovine Achilles tendon (BAT) collagen in sewage sludge and in soil. Additionally, an eco-toxicological test with the model organism Enchytraeus crypticus was performed to assess environmental hazard of the produced materials in soils...
April 30, 2018: Journal of Materials Science. Materials in Medicine
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