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Journal of Materials Science. Materials in Medicine

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https://www.readbyqxmd.com/read/28213747/bone-morphogenetic-protein-2-for-the-treatment-of-congenital-pseudarthrosis-of-the-tibia-or-persistent-tibial-nonunion-in-children-and-adolescents-a-retrospective-study-with-a-minimum-2-year-follow-up
#1
Tim N Hissnauer, Norbert Stiel, Kornelia Babin, Martin Rupprecht, Michael Hoffmann, Johannes M Rueger, Ralf Stuecker, Alexander S Spiro
There is a lack of studies reporting on rhBMP-2 application in pediatric orthopaedics, although few reports demonstrated promising results of the use of rhBMP-2 in children, especially for spine fusion and for the treatment of congenital pseudarthrosis of the tibia. The objectives of this study were (1) to examine clinical and radiographic healing after rhBMP-2 application for the treatment of congenital pseudarthrosis of the tibia (CPT) or persistent tibial nonunion in children and adolescents, and (2) to investigate the safety of rhBMP-2 use in these cases...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210971/scaffold-free-approach-produces-neocartilage-tissue-of-similar-quality-as-the-use-of-hystem%C3%A2-and-hydromatrix%C3%A2-scaffolds
#2
Janne H Ylärinne, Chengjuan Qu, Mikko J Lammi
Numerous biomaterials are being considered for cartilage tissue engineering, while scaffold-free systems have also been introduced. Thus, it is important to know do the scaffolds improve the formation of manufactured neocartilages. This study compares scaffold-free cultures to two scaffold-containing ones. Six million bovine primary chondrocytes were embedded in HyStem™ or HydroMatrix™ scaffolds, or suspended in scaffold-free chondrocyte culture medium, and then loaded into agarose gel supported culture well pockets...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210970/a-suspended-carbon-fiber-culture-to-model-myelination-by-human-schwann-cells
#3
Antonio Merolli, Yong Mao, Joachim Kohn
Understanding of myelination/remyelination process is essential to guide tissue engineering for nerve regeneration. In vitro models currently used are limited to cell population studies and cannot easily identify individual cell contribution to the process. We established a novel model to study the contribution of human Schwann cells to the myelination process. The model avoids the presence of neurons in culture; Schwann cells respond solely to the biophysical properties of an artificial axon. The model uses a single carbon fiber suspended in culture media far from the floor of the well...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210969/host-tissue-response-by-the-expression-of-collagen-to-cyanoacrylate-adhesives-used-in-implant-fixation-for-abdominal-hernia-repair
#4
Gemma Pascual, Marta Rodríguez, Bárbara Pérez-Köhler, Claudia Mesa-Ciller, Mar Fernández-Gutiérrez, Julio San Román, Juan M Bellón
The less traumatic use of surgical adhesives rather than sutures for mesh fixation in hernia repair has started to gain popularity because they induce less host tissue damage and provoke less postoperative pain. This study examines the host tissue response to a new cyanoacrylate (CA) adhesive (n-octyl, OCA). Partial defects (3 × 5 cm) created in the rabbit anterior abdominal wall were repaired by mesh fixation using OCA, Glubran2(®)(n-butyl-CA), Ifabond(®)(n-hexyl-CA) or sutures. Samples were obtained at 14/90 days for morphology, collagens qRT-PCR/immunofluorescence and biomechanical studies...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210968/study-on-critical-sized-ultra-high-molecular-weight-polyethylene-wear-particles-loaded-with-alendronate-sodium-in-vitro-release-and-cell-response
#5
Yumei Liu, Feng Shi, Kemeng Gong, Yang Liu, Wei Zhi, Jie Weng, Shuxin Qu
The aim of this study was to investigate the in vitro release and the effect of RAW 264.7 macrophages of critical-sized wear particles of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), one of the most effective drugs to treat osteoporosis in clinic. The critical-sized UHMWPE-ALN 0.5 wt.% wear particles were prepared by vacuum gradient filtration combined with Pluronic F-68. In vitro release of ALN from critical-sized UHMWPE-ALN wear particles was investigated in phosphate buffered saline (PBS) at 37 °C with a shaker...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28210967/core-shell-drug-carrier-from-folate-conjugated-chitosan-obtained-from-prawn-shell-for-targeted-doxorubicin-delivery
#6
Md Sazedul Islam, Papia Haque, Taslim U Rashid, M Nuruzzaman Khan, Abul K Mallik, M Nazrul I Khan, Mala Khan, Mohammed Mizanur Rahman
A multifunctional drug carrier with dual targeting (magnetic and folate-receptor) and pH sensitive core-shell hybrid nanomaterial has been developed to carry an anticancer drug doxorubicin.Superparamagnetic iron oxide nanoparticles (IONPs) were used as core of the carrier and cross-linked folate conjugated chitosan (FA-CS) was acted as shell in which doxorubicin was physically entrapped. Transmission electron microscopy (TEM) analysis confirmed the average particle size of IONPs and FA-CS coated IONPs 8.2 and 15...
April 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28197826/safety-and-efficacy-of-a-novel-abluminal-groove-filled-biodegradable-polymer-sirolimus-eluting-stent
#7
Jinzhou Zhu, Huizhu Liu, Haipo Cui, Zhirong Tang, Chengli Song, Ruiyan Zhang
Late stent thrombosis (LST) following drug-eluting stent (DES) implantation in patients with coronary artery disease (CAD) is often associated with delayed vascular healing, resulting from vascular inflammation and hypersensitivity to durable polymers and drugs. Therefore, DES design, materials, and coatings have been technologically revolutionized. Herein, we designed a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent (AGF-BP-SES), with a sirolimus content of only about one-third of traditional DES...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28197825/peculiarities-in-thermal-evolution-of-precipitated-amorphous-calcium-phosphates-with-an-initial-ca-p-ratio-of-1-1
#8
Zoltan Zyman, Matthias Epple, Anton Goncharenko, Dmytro Rokhmistrov, Oleg Prymak, Kateryna Loza
Thermal evolution of amorphous calcium phosphate (ACP) powder from a fast nitrate synthesis with a Ca/P ratio of 1:1 were studied in the range of 20-980 °C. The powder consisted of amorphous dicalcium phosphate anhydrate (CaHPO4) after heating to 200 °C. CaHPO4 gradually condensed to amorphous calcium pyrophosphate Ca2P2O7 (CPP) between 200 to 620 °C. Amorphous CPP crystallized at 620-740 °C to a metastable polymorph α'-CPP of the high-temperature phase α-CPP and β-CPP. The α'-CPP/ β-CPP phase ratio reached a maximum at 800 °C (60 wt% α'-CPP/40 wt% β-CPP), and α'-CPP gradually transformed to β-CPP at a higher temperature...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28197824/in-vitro-cytotoxicity-and-surface-topography-evaluation-of-additive-manufacturing-titanium-implant-materials
#9
Jukka T Tuomi, Roy V Björkstrand, Mikael L Pernu, Mika V J Salmi, Eero I Huotilainen, Jan E H Wolff, Pekka K Vallittu, Antti A Mäkitie
Custom-designed patient-specific implants and reconstruction plates are to date commonly manufactured using two different additive manufacturing (AM) technologies: direct metal laser sintering (DMLS) and electron beam melting (EBM). The purpose of this investigation was to characterize the surface structure and to assess the cytotoxicity of titanium alloys processed using DMLS and EBM technologies as the existing information on these issues is scarce. "Processed" and "polished" DMLS and EBM disks were assessed...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28197823/the-deposition-of-strontium-and-zinc-co-substituted-hydroxyapatite-coatings
#10
L Robinson, K Salma-Ancane, L Stipniece, B J Meenan, A R Boyd
The in vitro and in vivo performance of hydroxyapatite (HAp) coatings can be modified by the addition of different trace ions, such as silicon (Si), lithium (Li), magnesium (Mg), zinc (Zn) or strontium (Sr) into the HAp lattice, to more closely mirror the complex chemistry of human bone. To date, most of the work in the literature has considered single ion-substituted materials and coatings, with limited reports on co-substituted calcium phosphate systems. The aim of this study was to investigate the potential of radio frequency magnetron sputtering to deposit Sr and Zn co-substituted HAp coatings using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS)...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28197822/enhanced-repair-of-segmental-bone-defects-in-rabbit-radius-by-porous-tantalum-scaffolds-modified-with-the-rgd-peptide
#11
Hui Wang, Qijia Li, Qian Wang, Hui Zhang, Wei Shi, Hongquan Gan, Huiping Song, Zhiqiang Wang
Fast and stable repair of segmental bone defects remains a challenge for clinical orthopedic surgery. In recent years, porous tantalum has been widely applied in clinical orthopedics for low modulus of elasticity, with three-dimensional microstructures similar to cancellous bone and excellent biocompatibility. To further improve bone the repairing ability of porous tantalum, the cyclo(-RGDfK-) peptide was coated on the surface of porous tantalum scaffolds. A model of 15 mm segmental defect was made at the midshaft of right radius in New Zealand White rabbits...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28181101/preparation-of-hydroxyapatite-collagen-injectable-bone-paste-with-an-anti-washout-property-utilizing-sodium-alginate-part-1-influences-of-excess-supplementation-of-calcium-compounds
#12
Taira Sato, Masanori Kikuchi, Mamoru Aizawa
The anti-washout property, viscosity, and cytocompatibility to an osteoblastic cell line, MG-63, of anti-washout pastes were investigated. Mixing a hydroxyapatite/collagen bone-like nanocomposite (HAp/Col), an aqueous solution of sodium alginate (Na-Alg), which is a paste hardening and lubricant agent, and supplementation of calcium carbonate or calcium citrate (Ca-Cit) as a calcium resource for the hardening reaction realized an injectable bone paste. Adding Ca-Cit at a concentration greater than eight times the Ca(2+) ion concentration to Na-Alg improved the anti-washout property...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28176192/effect-of-the-up-front-heat-treatment-of-gelatin-particles-dispersed-in-calcium-phosphate-cements-on-the-in-vivo-material-resorption-and-concomitant-bone-formation
#13
Shoko Yamamoto, Yuta Matsushima, Yoshitaka Kanayama, Azusa Seki, Haruya Honda, Hidero Unuma, Yasuo Sakai
Calcium phosphate cements (CPCs), consisting of a mixture of calcium phosphate powders and setting liquid, have been widely used in orthopedic applications. One of the drawbacks of CPCs is their poor resorbability in the living body, which hinders substitution with natural bones. One of the strategies to facilitate the resorption of CPCs is the incorporation of bioresorbable or water-soluble pore-generating particles (porogens), such as gelatin, in the CPC matrices. In spite of numerous reports, however, little is known about the effect of the dissolution/resorption rate of the porogens on concomitant bone regeneration...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28176191/thin-chitosan-films-containing-super-paramagnetic-nanoparticles-with-contrasting-capability-in-magnetic-resonance-imaging
#14
Fatemeh Farjadian, Sahar Moradi, Majid Hosseini
Magnetic nanoparticles have found application as MRI contrasting agents. Herein, chitosan thin films containing super-paramagnetic iron oxide nanoparticles (SPIONs) are evaluated in magnetic resonance imaging (MRI). To determine their contrasting capability, super-paramagnetic nanoparticles coated with citrate (SPIONs-cit) were synthesized. Then, chitosan thin films with different concentrations of SPIONs-cit were prepared and their MRI data (i.e., r 2 and r 2*) was evaluated in an aqueous medium. The synthesized SPIONs-cit and chitosan/SPIONs-cit films were characterized by FTIR, EDX, XRD as well as VSM with the morphology evaluated by SEM and AFM...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28161832/enhanced-biosafety-of-silica-coated-gadolinium-based-nanoparticles
#15
Marta Laranjeira, Yuki Shirosaki, Saki Yoshimatsu Yasutomi, Toshiki Miyazaki, Fernando Jorge Monteiro
One of the most important and novel approaches of biomedical engineering is the development of new, effective and non-invasive medical diagnosis abilities, and treatments that have such requirements as advanced technologies for tumor imaging. Gadolinium (Gd) compounds can be used as MRI contrast agents, however the release of Gd(3+) ions presents some adverse side effects such as renal failure, pancreatitis or local necrosis. The main aim of the work was the development and optimization of Gadolinium based nanoparticles coated with silica to be used as bioimaging agent...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28155052/a-nanofibrous-electrospun-patch-to-maintain-human-mesenchymal-cell-stemness
#16
L Pandolfi, N Toledano Furman, Xin Wang, C Lupo, J O Martinez, M Mohamed, F Taraballi, E Tasciotti
Mesenchymal stem cells (MSCs) have been extensively investigated in regenerative medicine because of their crucial role in tissue healing. For these properties, they are widely tested in clinical trials, usually injected in cell suspension or in combination with tridimensional scaffolds. However, scaffolds can largely affect the fates of MSCs, inducing a progressive loss of functionality overtime. The ideal scaffold must delay MSCs differentiation until paracrine signals from the host induce their change. Herein, we proposed a nanostructured electrospun gelatin patch as an appropriate environment where human MSCs (hMSCs) can adhere, proliferate, and maintain their stemness...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28155051/a-review-on-animal-models-and-treatments-for-the-reconstruction-of-achilles-and-flexor-tendons
#17
Marta Bottagisio, Arianna B Lovati
Tendon is a connective tissue mainly composed of collagen fibers with peculiar mechanical properties essential to functional movements. The increasing incidence of tendon traumatic injuries and ruptures-associated or not with the loss of tissue-falls on the growing interest in the field of tissue engineering and regenerative medicine. The use of animal models is mandatory to deepen the knowledge of the tendon healing response to severe damages or acute transections. Thus, the selection of preclinical models is crucial to ensure a successful translation of effective and safe innovative treatments to the clinical practice...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28150116/subcutaneous-implantation-of%C3%A2-microencapsulated-cells-overexpressing-%C3%AE-l-iduronidase-for-mucopolysaccharidosis-type-i-treatment
#18
Valeska Lizzi Lagranha, Barbara Zambiasi Martinelli, Guilherme Baldo, Giuseppe Ávila Testa, Talita Giacomet de Carvalho, Roberto Giugliani, Ursula Matte
Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of α-L-iduronidase (IDUA), resulting in accumulation of glycosaminoglycans (GAG) in lysosomes. Microencapsulation of recombinant cells is a promising gene/cell therapy approach that could overcome the limitations of the current available treatments. In the present study we produced alginate-poly-L-lysine-alginate (APA) microcapsules containing recombinant cells overexpressing IDUA, which were implanted in the subcutaneous space of MPS I mice in order to evaluate their potential effect as a treatment for this disease...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28150115/green-synthesis-of-rifampicin-loaded-copper-nanoparticles-with-enhanced-antimicrobial-activity
#19
Marta J Woźniak-Budych, Łucja Przysiecka, Krzysztof Langer, Barbara Peplińska, Marcin Jarek, Maciej Wiesner, Grzegorz Nowaczyk, Stefan Jurga
The antimicrobial properties of copper and rifampicin-loaded copper nanoparticles were investigated using four strains: Staphylococcus aureus, Escherichia coli, Bacillus pumilis and Pseudomonas fluorescens. Spherical-shaped copper nanoparticles were synthesized via green reduction method from the peppermint extract. It was found that adsorption of rifampicin on the copper nanosurface enhances its biological activity and prevents the development of resistance. The interactions between rifampicin-copper nanoparticles and bacteria cells were monitored using atomic force microscopy (AFM) and confocal laser scanning microscopy (CLSM)...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28144853/compressive-fatigue-properties-of-an-acidic-calcium-phosphate-cement-effect-of-phase-composition
#20
Ingrid Ajaxon, Caroline Öhman Mägi, Cecilia Persson
Calcium phosphate cements (CPCs) are synthetic bone grafting materials that can be used in fracture stabilization and to fill bone voids after, e.g., bone tumour excision. Currently there are several calcium phosphate-based formulations available, but their use is partly limited by a lack of knowledge of their mechanical properties, in particular their resistance to mechanical loading over longer periods of time. Furthermore, depending on, e.g., setting conditions, the end product of acidic CPCs may be mainly brushite or monetite, which have been found to behave differently under quasi-static loading...
March 2017: Journal of Materials Science. Materials in Medicine
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