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Journal of Materials Science. Materials in Medicine

Lei Hong, Meiting Shen, Jiaxi Fang, Yezhao Wang, Zhiyuan Bao, Shizhong Bu, Yabin Zhu
In this work, two kinds of hyaluronic acid (HA)-based hydrogels were fabricated: one is made from physical freezing-thawing of HA solution (HA1), and the other is from chemical cross-linking of HA and polysaccharide (HA2). They were applied to repair full-thickness skin defects with New Zealand rabbits as the test animals, using powder HA and cotton dress as the references. The wound starts to heal after wounds were disinfected with iodine followed by coating with HA2, HA1, HA and cotton dress (the control), respectively...
September 8, 2018: Journal of Materials Science. Materials in Medicine
Tingting Wu, Shue Yang, Haishan Shi, Jiandong Ye
In a minimally invasive surgery, using a bone cement being radiologically detectable is vital to the success of the procedure and avoiding cement leakage in the early stage. The radiopacity of calcium phosphate cement (CPC) is inadequate, thus limiting its clinic application in this area. In this work, bismuth aluminate (BiA) was employed as a radiopaque agent for CPC. The influences of BiA on physicochemical, radiopaque and in vitro biocompatible properties of CPC were investigated. With the increasing content of BiA, the setting time and the compressive strength of CPC were augmented, while the injectability of the cement pastes was reduced...
September 4, 2018: Journal of Materials Science. Materials in Medicine
Yi Cui, Chao Lu, Bing Chen, Jin Han, Yannan Zhao, Zhifeng Xiao, Sufang Han, Juli Pan, Jianwu Dai
Mandibular defects, caused by congenital, pathological or iatrogenic insults, can significantly affect patient quality of life. The reconstruction of mandible has recently gained the interest of clinical and tissue engineering researchers. The purpose of this study was to evaluate the effectiveness of three-dimensional (3-D) cultured autologous grafts prepared using bone marrow-derived mesenchymal stem cells (BMSCs) combined with demineralized bone matrix (DBM) scaffolds for the restoration of mandibular defects...
August 31, 2018: Journal of Materials Science. Materials in Medicine
Yun-Feng Liu, Jian-Lei Wu, Shan-Ling Song, Li-Xin Xu, Jie Chen, Wei Peng
OBJECTIVES: Glass fiber reinforced shape memory polyurethane (GFRSMPU) has great potential to be an alternative kind of material for orthodontic archwires for overcoming the disadvantages of metal wires in terms of esthetic and allergy and deficiency of pure shape memory polyurethane (SMPU) wires in mechanical properties. The objective of this study was to investigate the thermo-mechanical properties and shape recovery functions of GFRSMPU and evaluate the feasibility of using this composite for orthodontic archwires...
August 31, 2018: Journal of Materials Science. Materials in Medicine
Lucie Válková, Jana Ševčíková, Monika Pávková Goldbergová, Adam Weiser, Antonín Dlouhý
Nickel-titanium alloy (nitinol, NiTi) is a biomaterial with unique thermal shape memory, superelasticity and high damping properties. Therefore NiTi has been used in medical applications. In this in vitro study, the effect of NiTi alloy (with two surface modifications - helium and hydrogen) on gene expression profile of selected interleukins (IL-1β, IL-6 and IL-8) and matrix metalloproteinases (MMP-1 and MMP-2) in human physiological osteoblasts and human osteoarthritic osteoblasts was examined to respond to a question of the different behavior of bone tissue in the implantation of metallic materials in the presence of cells affected by the osteoarthritic process...
August 30, 2018: Journal of Materials Science. Materials in Medicine
Abiramy Soundararajan, Jyorthana Muralidhar R, Ramya Dhandapani, Janani Radhakrishnan, Amrutha Manigandan, Sivashankari Kalyanasundaram, Swaminathan Sethuraman, Anuradha Subramanian
Fabricating nanofibrous scaffolds with robust blood compatibility remains an unmet challenge for cardiovascular applications since anti-thrombogenic surface coatings did not withstand physiological shear force. Hence, the present study envisages the influence of smooth and porous topographies of poly(lactic acid) (PLA) nanofibers on hemocompatibility as it could offer time-independent blood compatibility. Further, recent studies have evolved to integrate various contrasting agents for augmenting the prognostic properties of tissue engineered scaffolds; an attempt was also made to synthesize Curcumin-superparamagnetic iron oxide nanoparticle complex (Cur-SPION) as a contrasting agent and impregnated into PLA nanofibers for evaluating the blood compatibility...
August 29, 2018: Journal of Materials Science. Materials in Medicine
Sankalp Agarwal, Marie-Noelle Labour, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal
This paper reports the corrosion resistant and cytocompatible properties of the hyaluronic acid-silane coating on AZ31 Mg alloy. In this study, the osteoinductive properties of high molecular weight hyaluronic acid (HA, 1-4 MDa) and the corrosion protection of silane coatings were incorporated as a composite coating on biodegradable AZ31 Mg alloy for orthopaedic applications. The multi-step fabrication of coatings first involved dip coating of a passivated AZ31 Mg alloy with a methyltriethoxysilane-tetraethoxysilane sol-gel to deposit a dense, cross-linked and corrosion resistant silane coating (AZ31-MT)...
August 28, 2018: Journal of Materials Science. Materials in Medicine
Jennifer N Etter, Michael Karasinski, Jesse Ware, Rachael A Oldinski
A smart hydrogel material was used in combination with custom microfluidic devices (MFDs) to create microspheres for human mesenchymal stem cell (MSC) encapsulation. Methods for fabricating homogeneous stimuli-responsive microspheres for MSC encapsulation and cell delivery have gained interest to increase viability and manipulate microencapsulation within microspheres 10-1000 µm in diameter. Herein, MFDs were combined with non-toxic smart hydrogel materials to tune both the size and mechanics of the microspheres...
August 27, 2018: Journal of Materials Science. Materials in Medicine
Mengmeng Luo, Qing Li, Dongmei Wang, Chaoxiang Ge, Jingjie Wang, Kaihui Nan, Sen Lin
Chitosan (CS) based nanoparticles (NPs) have several advantages in delivering drugs. They are usually prepared in a micro-emulsion solvent system but this route can leave significant levels of potentially harmful organic solvent residue in the NPs. In this study, we prepared CS based nanocomposites using charge driven self-assembly in an aqueous buffer, thus avoiding the use of organic solvents. Doxorubicin (DOX) was covalently attached to positive charged CS with a legumain substrate peptide to confer targeted drug release property, since legumain is often overexpressed in tumors or tumor associated micro environments...
August 18, 2018: Journal of Materials Science. Materials in Medicine
Nan Zhang, Dewei Zhao, Na Liu, Yunfeng Wu, Jiahui Yang, Yuefei Wang, Huanxin Xie, Ye Ji, Changlong Zhou, Jinpeng Zhuang, Yaming Wang, Jinglong Yan
Surgical repair of bone defects remains challenging, and the search for alternative procedures is ongoing. Devices made of Mg for bone repair have received much attention owing to their good biocompatibility and mechanical properties. We developed a new type of scaffold made of a Mg-Zn-Ca alloy with a shape that mimics cortical bone and can be filled with morselized bone. We evaluated its durability and efficacy in a rabbit ulna-defect model. Three types of scaffold-surface coating were evaluated: group A, no coating; group B, a 10-μm microarc oxidation coating; group C, a hydrothermal duplex composite coating; and group D, an empty-defect control...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Bin Wu, Nobuyoshi Takeshita, Yang Wu, Sanjairaj Vijayavenkataraman, Khek Yu Ho, Wen Feng Lu, Jerry Ying Hsi Fuh
Several attempts have been made to fabricate esophageal tissue engineering scaffolds. However, most of these scaffolds possess randomly oriented fibres and uncontrollable pore sizes. In order to mimic the native esophageal tissue structure, electro-hydrodynamic jetting (e-jetting) was used in this study to fabricate scaffolds with aligned fibres and controlled pore size. A hydrophilic additive, Pluronic F127 (F127), was blended with polycaprolactone (PCL) to improve the wettability of the scaffolds and hence the cell adhesion...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Meng He, Xiaoyi Chen, Kui Cheng, Lingqing Dong, Wenjian Weng, Huiming Wang
Surface nanotopography and bioactive ions have been considered to play critical roles on the interactions of biomaterials with cells. In this study, a TiO2 nanorod film incorporated with Zn-containing bioactive glass (TiO2 /Zn-BG) was prepared on tantalum substrate, trying to evaluate the synergistic effects of nanotopograpgy and bioactive ions to promote cellular osteogenic differentiation activity. The expression of osteogenic-related genes, ALP as well as the ECM mineralization on TiO2 /Zn-BG film were significantly upregulated compared to that of the film without TiO2 nanorod nanostructure (Zn-BG) or without Zn (TiO2 /BG)...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Marianne Hollensteiner, David Fürst, Peter Augat, Falk Schrödl, Benjamin Esterer, Stefan Gabauer, Stefan Hunger, Michael Malek, Daniel Stephan, Andreas Schrempf
Cranial grafts are favored to reconstruct skeletal defects because of their reduced resorption and their histocompatibility. Training possibilities for novice surgeons include the "learning by doing" on the patient, specimens or simulators. Although the acceptance of simulators is growing, the major drawback is the lack of validated bone models. The aim of this study was to create and validate a realistic skull cap model and to show superiority compared to a commercially available skull model. Characteristic forces during machinery procedures were recorded and thickness parameters from the bony layers were obtained...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Merin Sara Thomas, Prasanth K S Pillai, Marisa Faria, Nereida Cordeiro, Hernane Barud, Sabu Thomas, Laly A Pothen
Fabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA-CHS composite, prepared by the electrospinning technique using a mixed solvent system. The addition of chitosan into PLA, offered decrease in fiber diameter in the composites with uniformity in the distribution of fibers with an optimum at 0...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Narges Saderi, Mina Rajabi, Babak Akbari, Masoumeh Firouzi, Zahra Hassannejad
In the field of nerve tissue engineering, nanofibrous scaffolds could be a promising candidate when they are incorporated with electrical cues. Unique physico-chemical properties of gold nanoparticles (AuNPs) make them an appropriate component for increasing the conductivity of scaffolds to enhance the electrical signal transfer between neural cells. The aim of this study was fabrication of AuNPs-doped nanofibrous scaffolds for peripheral nerve tissue engineering. Polycaprolactone (PCL)/chitosan mixtures with different concentrations of chitosan (0...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Shengjun Sun, Yilin Zhang, Deliang Zeng, Songmei Zhang, Fuqiang Zhang, Weiqiang Yu
Ti-based implants sometimes fail to integrate with surrounding bone tissue due to insufficiency of new bone formation and surface bonding. To overcome this problem, this research focused on establishing a sustained bone growth factor delivery system by applying anodized TiO2 nanotube arrays and PLGA film on the titanium implant surface. TiO2 nanotube arrays were made by anodic oxidation method, and were then filled with rhBMP2 by vacuum freeze-drying. Next, PLGA was deposition on the surface of this material...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Catarina Gonçalves-Pimentel, Giselle Machado Magalhães Moreno, Bruna Soares Trindade, Alinny Rosendo Isaac, Claudio Gabriel Rodrigues, Mythili Savariradjane, Amanda Vasconcelos de Albuquerque, José Lamartine de Andrade Aguiar, Belmira Lara da Silveira Andrade-da-Costa
Bacteria-synthesized polysaccharides have attracted interest for biomedical applications as promising biomaterials to be used as implants and scaffolds. The present study tested the hypothesis that cellulose exopolysaccharide (CEC) produced from sugarcane molasses of low cost and adequate purity would be suitable as a template for 2D and 3D neuron and/or astrocyte primary cultures, considering its low toxicity. CEC biocompatibility in these primary cultures was evaluated with respect to cell viability, adhesion, growth and cell function (calcium imaging)...
August 17, 2018: Journal of Materials Science. Materials in Medicine
Anna Lucia Gallo, Mauro Pollini, Federica Paladini
Chronic wounds and related infections cause physical and psychological distress in patients, increased mortality, disability and high health care costs. The healing process can be delayed by several factors and in particular by the risk of infections, which can be further complicated by the increasing number of antibiotic-resistant microorganisms. New approaches in wounds management have been encouraged, aiming at preventing infections and improving wound healing. In this scenario, silver has emerged as an ideal antimicrobial agent due to its recognized efficacy against bacteria, viruses and fungi...
August 9, 2018: Journal of Materials Science. Materials in Medicine
R S Brum, P R Monich, M C Fredel, G Contri, S D A S Ramoa, R S Magini, C A M Benfatti
Poly-ether-ether-ketone (PEEK) is one of the most important biocompatible polymers and its sulfonation has been studied for biomedical applications. The aim of the present study is to produce, to characterize and to assess bioactivity of PEEK coatings with sulfonated PEEK (SPEEK) films. Biomedical grade PEEK (Invibio®, Batch: D0602, grade: NI1) was functionalized using sulfuric acid 98%. SPEEK was dissolved into DMSO or into DMF, both at 10% mass/volume. PEEK bars (N = 18) and cylinders (N = 27) were manufactured by compression molding and heating...
August 9, 2018: Journal of Materials Science. Materials in Medicine
Javier Gil, Elisa Rupérez, Eugenio Velasco, Conrado Aparicio, José María Manero
The aim is to investigate the premature catastrophic fracture produced for different periods during clinical endodontic treatment of two brands of NiTi endodontic rotary instruments. 3 samples as-received, 6 samples used with patients for 2 and 7 h and 5 samples fractured were studied for each brand of endodontic NiTi rotary instruments. Transformation temperatures (Ms , Mf , As and Af ) and enthalpies of transformation were determined by calorimetry. Critical stresses until fracture (σβ→SIM , σSIM→β ) were obtained using an electromechanical testing machine...
August 7, 2018: Journal of Materials Science. Materials in Medicine
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