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Journal of Materials Science. Materials in Medicine

Louise Rydén, Omar Omar, Anna Johansson, Ryo Jimbo, Anders Palmquist, Peter Thomsen
It has been suggested that surface modification with a thin hydroxyapatite (HA) coating enhances the osseointegration of titanium implants. However, there is insufficient information about the biological processes involved in the HA-induced response. This study aimed to investigate the inflammatory cell response to titanium implants with either amorphous or crystalline thin HA. Human mononuclear cells were cultured on titanium discs with a machined surface or with a thin, 0.1 μm, amorphous or crystalline HA coating...
January 2017: Journal of Materials Science. Materials in Medicine
Concepcion Perez-Jorge, Maria-Angeles Arenas, Ana Conde, Juan-Manuel Hernández-Lopez, Juan-Jose de Damborenea, Steve Fisher, Alessandra M Agostinho Hunt, Jaime Esteban, Garth James
Orthopaedic device-related infections are closely linked to biofilm formation on the surfaces of these devices. Several modified titanium (Ti-6Al-4V) surfaces doped with fluorine were studied in order to evaluate the influence of these modifications on biofilm formation by Gram-positive and Gram-negative bacteria as well as a yeast. The biofilm studies were performed according to the standard test method approved by ASTM (Designation: E2196-12) using the Rotating Disk Reactor. Four types of Ti-6Al-4V samples were tested; chemically polished (CP), two types of nanostructures containing fluorine, nanoporous (NP) and nanotubular (NT), and non-nanostructured fluorine containing samples (fluoride barrier layers, FBL)...
January 2017: Journal of Materials Science. Materials in Medicine
Yun Ding, Rong Tian, Zhen Yang, Jianfa Chen, Naihao Lu
Previous studies have shown that carboxylated single-walled carbon nanotubes (SWCNTs) could be oxidatively biodegraded by neutrophil myeloperoxidase (MPO) and peroxynitrite (ONOO(-)). However, the biodegradation mechanism of nanotubes in macrophages has not been explored enough. Here, we showed that both MPO and ONOO(-) could effectively oxidize SWCNTs to generate shorter and oxidative nanotubes in vitro. SWCNTs were significantly degraded in zymosan-stimulated macrophages, and the degradation mechanism was dependent on MPO and ONOO(-)-driven oxidative pathways of activated macrophages, where NADPH oxidase was found to be a major determinant of the biodegradation process...
January 2017: Journal of Materials Science. Materials in Medicine
Joana C Antunes, Catarina Leite Pereira, Graciosa Q Teixeira, Ricardo V Silva, Joana Caldeira, Sibylle Grad, Raquel M Gonçalves, Mário A Barbosa
Intervertebral disc (IVD) degeneration often leads to low back pain, which is one of the major causes of disability worldwide, affecting more than 80% of the population. Although available treatments for degenerated IVD decrease symptoms' progression, they fail to address the underlying causes and to restore native IVD properties. Poly(γ-glutamic acid) (γ-PGA) has recently been shown to support the production of chondrogenic matrix by mesenchymal stem/stromal cells. γ-PGA/chitosan (Ch) nanocomplexes (NCs) have been proposed for several biomedical applications, showing advantages compared with either polymer alone...
January 2017: Journal of Materials Science. Materials in Medicine
Huan Dong, Tatiana Mukinay, Maojun Li, Richard Hood, Sein Leung Soo, Simon Cockshott, Rachel Sammons, Xiaoying Li
In this study, an advanced ceramic conversion surface engineering technology has been applied for the first time to self-drilling Ti6Al4V external fixation pins to improve their performance in terms of biomechanical, bio-tribological and antibacterial properties. Systematic characterisation of the ceramic conversion treated Ti pins was carried out using Scanning electron microscope, X-ray diffraction, Glow-discharge optical emission spectroscopy, nano- and micro-indentation and scratching; the biomechanical and bio-tribological properties of the surface engineered Ti pins were evaluated by insertion into high density bone simulation material; and the antibacterial behaviour was assessed with Staphylococcus aureus NCTC 6571...
January 2017: Journal of Materials Science. Materials in Medicine
Eric Leclerc, Jean-Luc Duval, Christophe Egles, Satoshi Ihida, Hiroshi Toshiyoshi, Agnès Tixier-Mita
Thin-Film-Transistors Liquid-Crystal Display has become a standard in the field of displays. However, the structure of these devices presents interest not only in that field, but also for biomedical applications. One of the key components, called here TFT substrate, is a glass substrate with a dense and large array of thousands of transparent micro-electrodes that can be considered as a large scale multi-electrode array(s). Multi-electrode array(s) are widely used for in vitro electrical investigations on neurons and brain, allowing excitation, registration, and recording of their activity...
January 2017: Journal of Materials Science. Materials in Medicine
Poon Nian Lim, Zuyong Wang, Lei Chang, Toshiisa Konishi, Cleo Choong, Bow Ho, Eng San Thian
Prevention of infection and enhanced osseointegration are closely related, and required for a successful orthopaedic implant, which necessitate implant designs to consider both criteria in tandem. A multi-material coating containing 1:1 ratio of silicon-substituted hydroxyapatite and silver-substituted hydroxyapatite as the top functional layer, and hydroxyapatite as the base layer, was produced via the drop-on-demand micro-dispensing technique, as a strategic approach in the fight against infection along with the promotion of bone tissue regeneration...
January 2017: Journal of Materials Science. Materials in Medicine
Feng-Zhen Liu, Da-Wei Wang, Yu-Jue Zhang, Zhao Yong Lv, Xiao-Dan Sun, Ke-Yi Li, Bin Zhang, Xiu-Mei Wang, Fu-Zhai Cui
Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it's of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on rabbit rib bone regeneration with and without graft were reported in this article. A segmental defect was performed on the 8th rib of 4-month-old male New Zealand rabbits...
January 2017: Journal of Materials Science. Materials in Medicine
Agnieszka Izabela Bochyńska, Gerjon Hannink, Dennis Janssen, Pieter Buma, Dirk W Grijpma
Isocyanate-terminated adhesive amphiphilic block copolymers are attractive materials to treat meniscus tears due to their tuneable mechanical properties and good adhesive characteristics. However, a drawback of this class of materials is their relatively long curing time. In this study, we evaluate the use of an amine cross-linker and addition of catalysts as two strategies to accelerate the curing rates of a recently developed biodegradable reactive isocyanate-terminated hyper-branched adhesive block copolymer prepared from polyethylene glycol (PEG), trimethylene carbonate, citric acid and hexamethylene diisocyanate...
January 2017: Journal of Materials Science. Materials in Medicine
Iwan Palmer, John Nelson, Wolfgang Schatton, Nicholas J Dunne, Fraser Buchanan, Susan A Clarke
This work establishes the in vivo performance of modified calcium phosphate bone cements for vertebroplasty of spinal fractures using a lapine model. A non-modified calcium phosphate bone cement and collagen-calcium phosphate bone cements composites with enhanced mechanical properties, utilising either bovine collagen or collagen from a marine sponge, were compared to a commercial poly(methyl methacrylate) cement. Conical cement samples (8 mm height × 4 mm base diameter) were press-fit into distal femoral condyle defects in New Zealand White rabbits and assessed after 5 and 10 weeks...
December 2016: Journal of Materials Science. Materials in Medicine
Kirsten Reddersen, Susanne Finger, Michael Zieger, Cornelia Wiegand, Hans-Jürgen Buschmann, Peter Elsner, Uta-Christina Hipler
Functionalized textiles can be used in wound management to reduce the microbial burden in the wound area, to prevent wound infections, and to avoid cross-contamination between patients. In the present study, a comprehensive in vitro approach to enable the assessment of antibacterial activity of functionalized textiles and cytotoxicity of cyclodextrin (CD)-complexes with chlorhexidine diacetate (CHX), iodine (IOD), and polihexanide (PHMB) is suggested to evaluate their properties for supporting optimal conditions for wound healing...
December 2016: Journal of Materials Science. Materials in Medicine
Faheem Ahmed, Nishat Arshi, Saurabh Dwivedi, Bon Heun Koo, Ameer Azam, Edreese Alsharaeh
In this work, large-scale and single-crystalline ZnO nanotubes were fabricated by a simple technique from an aqueous solution at a low temperature of 65 °C. According to detailed morphology, structural and compositional analyses showed that the ZnO nanotubes [diameter ~200 nm (wall thickness ~50 nm); length ~1 µm] have single-crystallite with wurtzite structure. As-prepared ZnO nanotubes showed an effective fluorescence quenching for the detection of calf thymus DNA. In particular, increasing DNA concentrations (5-50 µM) into the fixed concentration of ZnO nanotubes (50 µM) progressively quenched the intrinsic fluorescence of nanotubes, which showed that the nanotubes fluorescence was efficiently quenched upon binding to DNA...
December 2016: Journal of Materials Science. Materials in Medicine
Christina M A P Schuh, Xavier Monforte, Johannes Hackethal, Heinz Redl, Andreas H Teuschl
Schwann cells play a key role in peripheral nerve regeneration. Failure in sufficient formation of Büngner bands due to impaired Schwann cell proliferation has significant effects on the functional outcome after regeneration. Therefore, the growth substrate for Schwann cells should be considered with highest priority in any peripheral nerve tissue engineering approach. Due to its excellent biocompatibility silk fibroin has most recently attracted considerable interest as a biomaterial for use as conduit material in peripheral nerve regeneration...
December 2016: Journal of Materials Science. Materials in Medicine
Shelby A Skoog, Girish Kumar, Jiwen Zheng, Anirudha V Sumant, Peter L Goering, Roger J Narayan
Nanostructured biomaterials have been investigated for achieving desirable tissue-material interactions in medical implants. Ultrananocrystalline diamond (UNCD) and nanocrystalline diamond (NCD) coatings are the two most studied classes of synthetic diamond coatings; these materials are grown using chemical vapor deposition and are classified based on their nanostructure, grain size, and sp(3) content. UNCD and NCD are mechanically robust, chemically inert, biocompatible, and wear resistant, making them ideal implant coatings...
December 2016: Journal of Materials Science. Materials in Medicine
Marialucia Gallorini, Viviana di Giacomo, Valentina Di Valerio, Monica Rapino, Domenico Bosco, Andrea Travan, Mara Di Giulio, Roberta Di Pietro, Sergio Paoletti, Amelia Cataldi, Silvia Sancilio
Silver-based products have been proven to be effective in retarding and preventing bacterial growth since ancient times. In the field of restorative dentistry, the use of silver ions/nanoparticles has been explored to counteract bacterial infections, as silver can destroy bacterial cell walls by reacting with membrane proteins. However, it is also cytotoxic towards eukaryotic cells, which are capable of internalizing nanoparticles. In this work, we investigated the biological effects of Chitlac-nAg, a colloidal system based on a modified chitosan (Chitlac), administered for 24-48 h to a co-culture of primary human gingival fibroblasts and Streptococcus mitis in the presence of saliva, developed to mimic the microenvironment of the oral cavity...
December 2016: Journal of Materials Science. Materials in Medicine
Paulo Emilio Feuser, Juan Marcelo Carpio Arévalo, Enio Lima Junior, Gustavo Rodrigues Rossi, Edvaldo da Silva Trindade, Maria Eliane Merlin Rocha, Amanda Virtuoso Jacques, Eduardo Ricci-Júnior, Maria Claudia Santos-Silva, Claudia Sayer, Pedro H Hermes de Araújo
Lauryl gallate loaded in superparamagnetic poly(methyl methacrylate) nanoparticles surface modified with folic acid were synthesized by miniemulsion polymerization in just one step. In vitro biocompatibility and cytotoxicity assays on L929 (murine fibroblast), human red blood, and HeLa (uterine colon cancer) cells were performed. The effect of folic acid at the nanoparticles surface was evaluated through cellular uptake assays in HeLa cells. Results showed that the presence of folic acid did not affect substantially the polymer particle size (~120 nm), the superparamagnetic behavior, the encapsulation efficiency of lauryl gallate (~87 %), the Zeta potential (~38 mV) of the polymeric nanoparticles or the release profile of lauryl gallate...
December 2016: Journal of Materials Science. Materials in Medicine
Kyoung-Tak Kang, Sung-Hwan Kim, Juhyun Son, Young Han Lee, Heoung-Jae Chun
The objective of this paper was to evaluate in vivo material properties in order to address technical aspects of computational modeling of ligaments in the tibiofemoral joint using a probabilistic method. The laxity test was applied to the anterior-posterior drawer under 30° and 90° of flexion with a series of stress radiographs, a Telos device, and computed tomography. Ligament stiffness was investigated using sensitivity analysis based on the Monte-Carlo method with a subject-specific finite element model generated from in vivo computed tomography and magnetic resonance imaging data, subjected to laxity test conditions...
December 2016: Journal of Materials Science. Materials in Medicine
Norbert Stiel, Tim N Hissnauer, Martin Rupprecht, Kornelia Babin, Carsten W Schlickewei, Johannes M Rueger, Ralf Stuecker, Alexander S Spiro
The off-label use of recombinant human bone morphogenetic protein-2 to promote bone healing in adults has significantly increased in recent years, while reports of recombinant human bone morphogenetic protein-2 application in children and adolescents are very rare. The aim of this study was to evaluate the safety of single and repetitive recombinant human bone morphogenetic protein-2 use in pediatric orthoapedics. Therefore we reviewed the medical records of 39 patients who had been treated with recombinant human bone morphogenetic protein-2 at our institution...
December 2016: Journal of Materials Science. Materials in Medicine
Surena Vahabi, Maryam Torshabi, Azadeh Esmaeil Nejad
Predictable regeneration of alveolar bone defects has always been a challenge in implant dentistry. Bone allografts are widely used bone substitutes with controversial osteoinductive activity. This in vitro study aimed to assess the osteogenic potential of some commercially available freeze-dried bone allografts supplemented with human recombinant platelet-derived growth factor-BB and transforming growth factor beta-1. Cell viability, mineralization, and osteogenic gene expression of MG-63 osteoblast-like cells were compared among the allograft alone, allograft/platelet-derived growth factor-BB, allograft/transforming growth factor beta-1, and allograft/platelet-derived growth factor-BB/transforming growth factor beta-1 groups...
December 2016: Journal of Materials Science. Materials in Medicine
Maria Giretova, Lubomir Medvecky, Radoslava Stulajterova, Tibor Sopcak, Jaroslav Briancin, Monika Tatarkova
Polyhydroxybutyrate/chitosan/calcium phosphate composites are interesting biomaterials for utilization in regenerative medicine and they may by applied in reconstruction of deeper subchondral defects. Insufficient informations were found in recent papers about the influence of lysozyme degradation of chitosan in calcium phosphate/chitosan based composites on in vitro cytotoxicity and proliferation activity of osteoblasts. The effect of enzymatic chitosan degradation on osteoblasts proliferation was studied on composite films in which the porosity of origin 3D scaffolds was eliminated and the surface texture was modified...
December 2016: Journal of Materials Science. Materials in Medicine
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