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Behavioural Pharmacology

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https://www.readbyqxmd.com/read/29239974/additive-and-subadditive-antiallodynic-interactions-between-%C3%AE-opioid-agonists-and-n-methyl-d-aspartate-antagonists-in-male-rhesus-monkeys
#1
Jeremy C Cornelissen, Floyd F Steele, Kenner C Rice, Katherine L Nicholson, Matthew L Banks
μ-Opioid agonists are clinically effective analgesics, but also produce undesirable effects such as sedation and abuse potential that limit their clinical utility. Glutamatergic systems also modulate nociception and N-methyl D-aspartate (NMDA) receptor antagonists have been proposed as one useful adjunct to enhance the therapeutic effects and/or attenuate the undesirable effects of μ-opioid agonists. Whether NMDA antagonists enhance the antiallodynic effects of μ-agonists in preclinical models of thermal hypersensitivity (i...
December 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29239973/involvement-of-adenosine-triphosphate-sensitive-potassium-channels-in-the-neuroprotective-activity-of-hydrogen-sulfide-in-the-6-hydroxydopamine-induced-animal-model-of-parkinson-s-disease
#2
Mohammad Reza Sarookhani, Hashem Haghdoost-Yazdi, Ali Sarbazi-Golezari, Arvin Babayan-Tazehkand, Nafiseh Rastgoo
Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity of H2S in vivo. Here, we evaluated the effect of glibenclamide, an ATP-sensitive potassium channel blocker, on the neuroprotective activity of H2S in the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease. 6-OHDA was administered by stereotaxic surgery into the medial forebrain bundle...
December 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29200003/effects-of-the-antidepressants-desipramine-and-fluvoxamine-on-latency-to-immobility-and-duration-of-immobility-in-the-forced-swim-test-in-adult-male-c57bl-6j-mice
#3
Wouter Koek, Thomas L Sandoval, Lynette C Daws
The forced swim test in rodents allows rapid detection of substances with antidepressant-like activity, evidenced as a decreased duration of immobility that is produced by the majority of clinically used antidepressants. Antidepressants also increase the latency to immobility, and this additional measure reportedly can increase the sensitivity of the forced swim test in mice. Extending these findings, the present study examined the effects of desipramine and fluvoxamine in a forced swim test in C57BL/6J mice, a strain commonly used as background for genetic modifications, analyzing results with a method (i...
December 1, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29194070/changes-in-gut-microbiota-during-development-of-compulsive-checking-and-locomotor-sensitization-induced-by-chronic-treatment-with-the-dopamine-agonist-quinpirole
#4
Tony D Jung, Paul S Jung, Lucshman Raveendran, Yasamin Farbod, Anna Dvorkin-Gheva, Boris Sakic, Michael G Surette, Henry Szechtman
Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined whether changes in gut microbiota play a role in these behavioral phenomena ηP, by monitoring the development of compulsive checking and locomotor sensitization at the same time as measuring the response of gut microbiota to chronic quinpirole injections...
November 29, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29176430/the-role-of-n-methyl-d-aspartate-receptors-and-metabotropic-glutamate-receptor-5-in-the-prepulse-inhibition-paradigms-for-studying-schizophrenia-pharmacology-neurodevelopment-and-genetics
#5
Zhemeng Wu, Zhigang Yang, Mengjiao Zhang, Xiaohan Bao, Fang Han, Liang Li
Treatments for the positive and negative symptoms of schizophrenia have been explored for decades, but no completely successful therapy has been found as yet. Metabotropic glutamate receptor 5 (mGluR5), which potentiates N-methyl-D-aspartate receptors in brain regions implicated in schizophrenia, has become a novel drug target in the treatment of schizophrenia, especially for the mGluR5-positive allosteric modulators. Individuals with schizophrenia show deficits in prepulse inhibition (PPI), which is an operational measurement of sensorimotor gating...
November 24, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29176443/levosimendan-enhances-memory-through-antioxidant-effect-in-rat-model-behavioral-and-molecular-study
#6
Abeer M Rababa'h, Karem H Alzoubi, Ala'a Atmeh
Impairment of learning and memory has been associated with accumulation of reactive oxygen species in the body. It has also been found that antioxidants enhance learning and memory. Levosimendan is a cardiac inotropic and vasodilator agent that has pleotropic effects including antioxidant, anti-inflammatory, and smooth muscle vasodilatory actions. In this study, we investigated the effect of levosimendan on learning and memory in rats. Levosimendan (12 µg/kg, intraperitoneally) or vehicle was administered once a week for 8 weeks...
November 21, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29076866/antidepressant-like-effect-of-fluoxetine-may-depend-on-translocator-protein-activity-and-pretest-session-duration-in-forced-swimming-test-in-mice
#7
Nikita V Kudryashov, Tatiana S Kalinina, Alexander A Shimshirt, Anton O Korolev, Anna V Volkova, Tatiana A Voronina
The antidepressant-like effect of fluoxetine (20 mg/kg i.p.) has been assessed using the forced swimming test (FST) in IRC (CD-1) mice exposed or not to a pretest session of different duration (5 or 20 min). The influence of the mitochondrial translocator protein (TSPO) activity on the antidepressant-like effect of fluoxetine (20 mg/kg i.p.) in the FST was also studied. The antidepressant-like effect of fluoxetine was observed only in mice subjected to a 5-min pretest session 24 h before the FST. The TSPO antagonist PK11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; 1 or 3 mg/kg i...
October 25, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29064842/effect-of-varenicline-on-behavioral-deficits-in-a-rat-model-of-parkinson-s-disease-induced-by-unilateral-6-hydroxydopamine-lesion-of-substantia-nigra
#8
Rüyal Tan, Funda Bölükbaşi Hatip, Öznur Açikalin, Atsushi Yamauchi, Yasufumi Kataoka, Izzettin Hatip-Al-Khatib
Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at α4β2 and full agonist at α7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra (SN) has been used as a reliable model of PD. This study aimed to investigate the effect of varenicline on locomotor and nonlocomotor behavioral deficits induced by a unilateral lesion of the SN induced by 6-hydroxydopamine (6-OHDA) (8 µg/4 µl). Varenicline (1 mg/kg) was administered to the lesioned rats daily for 2 weeks, which commenced 3 weeks after 6-OHDA administration...
October 23, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29064841/the-effect-of-nicotine-pre-exposure-on-demand-for-cocaine-and-sucrose-in-male-rats
#9
Lindsay P Schwartz, David N Kearns, Alan Silberberg
The aim of the present study was to determine how nicotine pre-exposure affects the elasticity of demand for intravenous cocaine and for sucrose pellets in adult male rats. In Experiment 1, demand for cocaine was assessed in rats that had nicotine in their drinking water. Nicotine pre-exposure significantly decreased rats' willingness to defend cocaine consumption as the price (measured as the number of responses per cocaine infusion) increased compared with a control group with no nicotine pre-exposure. That is, nicotine increased the elasticity of demand for cocaine infusions...
October 23, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035921/biphasic-effects-of-selective-serotonin-reuptake-inhibitors-on-anxiety-rapid-reversal-of-escitalopram-s-anxiogenic-effects-in-the-novelty-induced-hypophagia-test-in-mice
#10
Wouter Koek, Nathan C Mitchell, Lynette C Daws
In humans, chronic treatment with selective serotonin reuptake inhibitors (SSRIs) decreases anxiety, unlike acute treatment, which can increase anxiety. Although this biphasic pattern is observed clinically, preclinical demonstrations are rare. In an animal model of antidepressant-induced anxiolytic effects, the novelty-induced hypophagia (NIH) test, a single administration of the SSRI citalopram reportedly elicited anxiogenic-like effects, whereas three administrations over 24 h were sufficient to produce anxiolytic-like effects...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035920/the-antidepressant-like-effects-of-sinomenine-in-mice-a-behavioral-and-neurobiological-characterization
#11
Xiuqin Li, Chao Liu, Bo Jiang, Kai Chen, Wenjuan Li, Hongze Wang
Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we investigated the antidepressant effects of sinomenine in mice. The antidepressant actions of sinomenine were first examined in the forced-swim test and the tail-suspension test, and then assessed in the chronic social defeat stress (CSDS) model of depression. Changes in the brain-derived neurotrophic factor (BDNF) signaling pathway after CSDS and sinomenine treatment were also investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor were also used to determine the pharmacological mechanisms of sinomenine...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035919/attenuation-of-compulsive-like-behavior-by-fluvoxamine-in-a-non-induced-mouse-model-of-obsessive-compulsive-disorder
#12
Swarup Mitra, Abel Bult-Ito
The current study evaluated the role of strain and compulsive trait differences in response to fluvoxamine, a common obsessive-compulsive disorder (OCD) drug, in two different mouse strains (BIG1 and BIG2) with a spontaneous compulsive-like phenotype. For compulsive-like nest-building behavior, dose-dependent attenuation of nesting by fluvoxamine was observed for the BIG1 compulsive-like strain during the first hour after administration. No significant differences were found for the BIG2 strain during the first hour, although a dose-dependent trend similar to that in the BIG1 strain was observed...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035918/dopaminergic-mechanisms-in-periaqueductal-gray-mediated-antinociception
#13
Glaucia Tobaldini, Rafael A Reis, Natalia F Sardi, Mayla K Lazzarim, Dabna H Tomim, Marcelo M S Lima, Luana Fischer
As important as perceiving pain is the ability to modulate this perception in some contextual salient situations. The periaqueductal gray (PAG) is perhaps the most important site of endogenous pain modulation; however, little is known about dopaminergic mechanisms underlying PAG-mediated antinociception. In this study, we used a pharmacological approach to evaluate this subject. We found that µ-opioid receptor-induced antinociception (DAMGO, 0.3 μg) from PAG was blocked by the coadministration of either D1-like or D2-like dopaminergic antagonists (SCH23390, 2, 4, and 6 μg or raclopride, 2 and 4 μg, respectively) both in the tail-flick and in the mechanical paw-withdrawal test...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29035917/decreases-in-smoking-during-treatment-for-methamphetamine-use-disorders-preliminary-evidence
#14
Sterling McPherson, Michael Orr, Crystal Lederhos, Michael McDonell, Emily Leickly, Katherine Hirchak, Oladunni A Oluwoye, Sean M Murphy, Matthew Layton, John M Roll
Despite high rates of smoking (70-90%) and the severely negative impact of smoking on physical and mental health, only 12% of individuals receiving stimulant-use disorder treatment also receive smoking-cessation treatment. The aim of this investigation was to examine the effect of a contingency management (CM) intervention targeting methamphetamine (MA) use on cigarette smoking. Sixty-one adults with MA-use disorders who were smokers were assigned to CM or standard psychosocial treatment. Rates of smoking-negative breath samples (carbon monoxide <3 ppm) were compared between the two groups while controlling for baseline carbon monoxide level, marijuana use, MA use, and time...
October 13, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28952976/effects-of-morphine-cp55940-mixtures-on-an-impulsive-choice-task-in-rhesus-monkeys
#15
Vanessa Minervini, Charles P France
µ-Opioid receptor agonists are commonly used to treat pain despite their adverse effects. In preclinical studies, cannabinoid receptor agonists increase the potency of opioids for producing antinociceptive but not reinforcing effects. It is unknown whether other adverse effects of these drugs, such as impairment of complex behavior, are enhanced by their co-administration. This study characterized the effects of morphine (µ-opioid receptor agonist; 0.32-5.6 mg/kg, subcutaneously) and CP55940 (CB1/CB2 cannabinoid receptor agonist; 0...
September 25, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28926343/the-impact-of-stress-on-social-behavior-in-adult-zebrafish-danio-rerio
#16
Shannon M Saszik, Conor M Smith
Stress has adverse effects on social behavior that is mediated by dopamine circuits in the midbrain. The purpose of this research is to examine the effect of chronic stress and dopamine signals on social behavior in zebrafish (Danio rerio). Chronic stress was induced chemically with low dosage of ethanol (0.25% for 5 days), and psychosocially with isolation (3-5 days) or overcrowding (5 days). Dopamine activity was decreased by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure. Social behavior was observed by introducing one treated zebrafish to a group of four control zebrafish and measuring the nearest neighbor distance (NND)...
September 18, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29120948/parvalbumin-containing-gaba-cells-and-schizophrenia-experimental-model-based-on-targeted-gene-delivery-through-adeno-associated-viruses
#17
Marta U Woloszynowska-Fraser, Peer Wulff, Gernot Riedel
Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29120947/novel-techniques-for-the-study-of-drugs-and-behaviour
#18
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29099404/differential-effects-of-dopaminergic-drugs-on-spontaneous-motor-activity-in-the-common-marmoset-following-pretreatment-with-a-bilateral-brain-infusion-of-6-hydroxydopamine
#19
Kiyoshi Ando, Chiyoko Nishime, Ryo Inoue, Eiko Nishinaka, Kenji Kawai, Koji Urano, Hideki Tsutsumi
The differential effects of dopaminergic drugs with different pharmacological profiles were investigated with respect to spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine (6-OHDA). Three marmosets received infusions of 6-OHDA (either 30 or 40 μg/side) into the bilateral dopamine-rich area running from the substantia nigra to the striatum. The motor activity of the 6-OHDA marmosets was compared with that of three intact marmosets...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29099403/considerations-for-the-use-of-virally-delivered-genetic-tools-for-in-vivo-circuit-analysis-and-behavior-in-mutant-mice-a-practical-guide-to-optogenetics
#20
Dóra Zelena, Kornél Demeter, József Haller, Diána Balázsfi
Optogenetics was the method of the year in 2010 according to Nature Neuroscience. Since then, this method has become widespread, the use of virally delivered genetic tools has extended to other fields such as pharmacogenetics, and optogenetic techniques have become frequently applied in genetically manipulated animals for in-vivo circuit analysis and behavioral studies. However, several issues should be taken into consideration when planning such experiments. We aimed to summarize the critical points concerning optogenetic manipulation of a specific brain area in mutant mice...
December 2017: Behavioural Pharmacology
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