Mukaddes Pala, Ismail Meral, Nilgün Pala Acikgoz, Murat Mengi, Meryem Betül Erdim Gokce, Rumeysa Unsal, Yalcin Polat, Fahri Akbas, Senay Gorucu Yilmaz
microRNAs (miRNAs) play a significant role in the pathophysiology of Parkinson's disease. In this study, we evaluated the neuroprotective effect of thymoquinone on the expression profiles of miRNA and cognitive functions in the 6-hydroxydopamine (6-OHDA)-induced Parkinson's model. Male adult Wistar albino rats (200-230 g, n = 36) were randomly assigned to six groups: Sham, thymoquinone (10 mg/kg, p.o.), 6-OHDA, 6-OHDA + thymoquinone (10 mg/kg), 6-OHDA + thymoquinone (20 mg/kg), and 6-OHDA + thymoquinone (50 mg/kg)...
April 25, 2024: Behavioural Pharmacology