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Behavioural Pharmacology

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https://www.readbyqxmd.com/read/29462112/microinjection-of-the-mglur2-3-agonist-ly379268-into-the-nucleus-accumbens-attenuates-extinction-latencies-and-the-reinstatement-of-morphine-induced-conditioned-place-preference-in-rats
#1
Negar Baharlouei, Abdolrahman Sarihi, Marzieh Moradi, Shahram Zarrabian, Abbas Haghparast
Previous studies indicate that metabotropic glutamate receptor type 2/3 (mGluR2/3) has a key role in the rewarding properties of morphine-induced conditioning place preference (CPP). Group II mGluR2/3 agonists are offered as a drug addiction treatment. The nucleus accumbens (NAc), which is one of the important areas involved in the reward circuitry, also expresses these receptors. In this study, we evaluated the effects of mGluR2/3 agonist, LY379268, on the extinction and reinstatement of morphine-induced CPP, following its microinjection into the NAc...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29462111/medication-overuse-headache-following-repeated-morphine-but-not-increment-9-tetrahydrocannabinol-administration-in-the-female-rat
#2
Ram Kandasamy, Cole T Dawson, Tammy N Hilgendorf, Michael M Morgan
The potential of [INCREMENT]-tetrahydrocannabinol (THC) as a treatment for migraine depends on antinociceptive efficacy with repeated administration. Although morphine has good antinociceptive efficacy, repeated administration causes medication overuse headache (MOH) - a condition in which the intensity/frequency of migraine increases. The present study compared the effect of repeated morphine or THC administration on the magnitude and duration of migraine-like pain induced by a microinjection of allyl isothiocyanate (AITC) onto the dura mater of female rats...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29462110/strain-differences-in-the-susceptibility-to-the-gut-brain-axis-and-neurobehavioural-alterations-induced-by-maternal-immune-activation-in-mice
#3
Livia H Morais, Daniela Felice, Anna V Golubeva, Gerard Moloney, Timothy G Dinan, John F Cryan
There is a growing realization that the severity of the core symptoms of autism spectrum disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless, the mechanisms underlying such comorbidities remain unknown. Several genetic and environmental factors have been linked to a higher susceptibility to neurodevelopmental abnormalities. The maternal immune activation (MIA) rodent model is a valuable tool for elucidating the basis of this interaction. We induced MIA with polyinosinic-polycytidylic acid (poly I:C) at gestational day 12...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29462109/effects-of-the-active-constituents-of-crocus-sativus-l-crocins-and-their-combination-with-memantine-on-recognition-memory-in-rats
#4
Nikolaos Pitsikas, Petros A Tarantilis
Crocus sativus L., is a plant cultivated in many countries of the world. Crocins are among the active constituents of C. sativus and their implication in cognition has been proposed. The present study was designed to investigate in the rat the effects of crocins on distinct recognition memory components (encoding, storage and retrieval). Subsequently, the potential use of crocins as adjunctive agents for the treatment of memory disorders was examined. Thus, the effects exerted by a combination of subthreshold doses of crocins and memantine on recognition memory were evaluated...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29462108/disulfiram-attenuates-morphine-or-methadone-withdrawal-syndrome-in-mice
#5
Anna de Cordé, Paweł Krząścik, Renata Wolińska, Patrycja Kleczkowska, Małgorzata Filip, Magdalena Bujalska-Zadrożny
Taking opioids is often accompanied by the development of dependence. Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse. In the presented study, we analyzed the potential influence of disulfiram, a drug used to aid the management of alcoholism, on opioid abstinence syndrome, which occurs as a result of opioid withdrawal. Opioid dependence in mice was induced by subcutaneous administration of either morphine or methadone at a dose of 48 mg/kg for 10 consecutive days...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461983/corticosterone-impairs-flexible-adjustment-of-spatial-navigation-in-an-associative-place-reward-learning-task
#6
Silviu I Rusu, Jan V Lankelma, Jadin C Jackson, Laura A Van Mourik-Donga, Marian Joëls, Cyriel M A Pennartz
Cognitive challenges are often accompanied by a discharge of stress hormones, which in turn modulate multiple brain areas. Among these, the medial temporal lobe and the prefrontal cortex are critically involved in high-order cognitive functions such as learning, memory, and decision-making. Previous studies assessing the effects of corticosterone on spatial memory found an increase or a decrease in performance depending on the timing of stress hormone discharge relative to the behavioral task. Most of these studies, however, made use of aversively motivated behaviors, whereas less is known about corticosteroid effects on flexible learning during reward-driven spatial navigation...
February 14, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29369054/lack-of-paclitaxel-effects-on-intracranial-self-stimulation-in-male-and-female-rats-comparison-to-mechanical-sensitivity
#7
Luke P Legakis, John W Bigbee, S Stevens Negus
Paclitaxel is a cancer chemotherapy with adverse effects that include peripheral neuropathy, neuropathic pain, and depression of behavior and mood. In rodents, hypersensitive paw-withdrawal reflexes from mechanical stimuli serve as one common measure of paclitaxel-induced pain-related behavior. This study tested the hypothesis that paclitaxel would also depress rates of positively reinforced operant responding as a measure of pain-related behavioral depression. Male and female Sprague-Dawley rats were equipped with electrodes targeting the medial forebrain bundle, trained to lever press for electrical brain stimulation in an assay of intracranial self-stimulation (ICSS), and treated with four injections of varying paclitaxel doses (0...
January 23, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29319543/choline-acetyltransferase-and-trka-expression-as-well-as-the-improvement-in-cognition-produced-by-e2-and-p4-in-ovariectomized-rats-are-blocked-by-ici-182%C3%A2-780-and-ru486
#8
Judith Espinosa-Raya, Ulises Cruz-Raya, Margarita López-Martínez, Ofir Picazo
Treatment with 17-β estradiol and progesterone improves the performance of ovariectomized rats in an autoshaping learning task, representing cognitive improvement. To test whether this is attributable to genomic mechanisms, the antiestrogen ICI 182 780 or antiprogesterone RU486 was injected into ovariectomized animals primed previously with estrogen or progesterone, respectively. Compared with the vehicle control, each hormone administered alone produced an elevated expression of choline acetyltransferase and TrkA, along with an improvement in performance on the behavioral test...
January 9, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29256893/enhanced-antinociception-with-repeated-microinjections-of-apomorphine-into-the-periaqueductal-gray-of-male-and-female-rats
#9
Shauna M Schoo, Erin N Bobeck, Michael M Morgan
Dopamine neurons in the ventrolateral periaqueductal gray (PAG) have been reported to contribute to antinociception. The objective of this study was to determine how this dopamine-mediated antinociception differs from what is known about morphine-induced antinociception. Microinjection of the dopamine receptor agonist apomorphine into the PAG produced a dose-dependent increase in hot plate latency and a decrease in open field activity that was greater in male than in female rats. The peak antinociceptive effect occurred 5 min after apomorphine administration...
December 18, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29239974/additive-and-subadditive-antiallodynic-interactions-between-%C3%AE-opioid-agonists-and-n-methyl-d-aspartate-antagonists-in-male-rhesus-monkeys
#10
Jeremy C Cornelissen, Floyd F Steele, Kenner C Rice, Katherine L Nicholson, Matthew L Banks
μ-Opioid agonists are clinically effective analgesics, but also produce undesirable effects such as sedation and abuse potential that limit their clinical utility. Glutamatergic systems also modulate nociception and N-methyl D-aspartate (NMDA) receptor antagonists have been proposed as one useful adjunct to enhance the therapeutic effects and/or attenuate the undesirable effects of μ-opioid agonists. Whether NMDA antagonists enhance the antiallodynic effects of μ-agonists in preclinical models of thermal hypersensitivity (i...
December 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29239973/involvement-of-adenosine-triphosphate-sensitive-potassium-channels-in-the-neuroprotective-activity-of-hydrogen-sulfide-in-the-6-hydroxydopamine-induced-animal-model-of-parkinson-s-disease
#11
Mohammad Reza Sarookhani, Hashem Haghdoost-Yazdi, Ali Sarbazi-Golezari, Arvin Babayan-Tazehkand, Nafiseh Rastgoo
Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity of H2S in vivo. Here, we evaluated the effect of glibenclamide, an ATP-sensitive potassium channel blocker, on the neuroprotective activity of H2S in the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease. 6-OHDA was administered by stereotaxic surgery into the medial forebrain bundle...
December 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29200003/effects-of-the-antidepressants-desipramine-and-fluvoxamine-on-latency-to-immobility-and-duration-of-immobility-in-the-forced-swim-test-in-adult-male-c57bl-6j-mice
#12
Wouter Koek, Thomas L Sandoval, Lynette C Daws
The forced swim test in rodents allows rapid detection of substances with antidepressant-like activity, evidenced as a decreased duration of immobility that is produced by the majority of clinically used antidepressants. Antidepressants also increase the latency to immobility, and this additional measure reportedly can increase the sensitivity of the forced swim test in mice. Extending these findings, the present study examined the effects of desipramine and fluvoxamine in a forced swim test in C57BL/6J mice, a strain commonly used as background for genetic modifications, analyzing results with a method (i...
December 1, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29194070/changes-in-gut-microbiota-during-development-of-compulsive-checking-and-locomotor-sensitization-induced-by-chronic-treatment-with-the-dopamine-agonist-quinpirole
#13
Tony D Jung, Paul S Jung, Lucshman Raveendran, Yasamin Farbod, Anna Dvorkin-Gheva, Boris Sakic, Michael G Surette, Henry Szechtman
Long-term treatment of rats with the D2/D3 dopamine agonist quinpirole induces compulsive checking (proposed as animal model of obsessive-compulsive disorder) and locomotor sensitization. The mechanisms by which long-term use of quinpirole produces those behavioral transformations are not known. Here we examined whether changes in gut microbiota play a role in these behavioral phenomena ηP, by monitoring the development of compulsive checking and locomotor sensitization at the same time as measuring the response of gut microbiota to chronic quinpirole injections...
November 29, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29120948/parvalbumin-containing-gaba-cells-and-schizophrenia-experimental-model-based-on-targeted-gene-delivery-through-adeno-associated-viruses
#14
Marta U Woloszynowska-Fraser, Peer Wulff, Gernot Riedel
Understanding the contribution of transmitter systems in behavioural pharmacology has a long tradition. Multiple techniques such as transmitter-specific lesions, and also localized administration of pharmacological toxins including agonists and antagonists of selected receptors have been applied. More recently, modern genetic tools have permitted cell-type selective interferences, for example by expression of light-sensitive channels followed by optogenetic stimulation in behaviourally meaningful settings or by engineered channels termed DREADDS that respond to peripherally administered drugs...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29120947/novel-techniques-for-the-study-of-drugs-and-behaviour
#15
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29099404/differential-effects-of-dopaminergic-drugs-on-spontaneous-motor-activity-in-the-common-marmoset-following-pretreatment-with-a-bilateral-brain-infusion-of-6-hydroxydopamine
#16
Kiyoshi Ando, Chiyoko Nishime, Ryo Inoue, Eiko Nishinaka, Kenji Kawai, Koji Urano, Hideki Tsutsumi
The differential effects of dopaminergic drugs with different pharmacological profiles were investigated with respect to spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine (6-OHDA). Three marmosets received infusions of 6-OHDA (either 30 or 40 μg/side) into the bilateral dopamine-rich area running from the substantia nigra to the striatum. The motor activity of the 6-OHDA marmosets was compared with that of three intact marmosets...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29099403/considerations-for-the-use-of-virally-delivered-genetic-tools-for-in-vivo-circuit-analysis-and-behavior-in-mutant-mice-a-practical-guide-to-optogenetics
#17
Dóra Zelena, Kornél Demeter, József Haller, Diána Balázsfi
Optogenetics was the method of the year in 2010 according to Nature Neuroscience. Since then, this method has become widespread, the use of virally delivered genetic tools has extended to other fields such as pharmacogenetics, and optogenetic techniques have become frequently applied in genetically manipulated animals for in-vivo circuit analysis and behavioral studies. However, several issues should be taken into consideration when planning such experiments. We aimed to summarize the critical points concerning optogenetic manipulation of a specific brain area in mutant mice...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29099402/simultaneous-monitoring-of-electroencephalographic-characteristics-in-animals-subjected-to-behavioral-tests-a-preclinical-investigation
#18
Ramakrishna Nirogi, Saivishal Daripelli, Vijay Benade, Chaitanya Tirumalasetty, Gopinadh Bhyrapuneni, Pradeep Jayarajan
Drug-induced changes in electroencephalographic (EEG) characteristics in animals may be used to predict central activity of drugs in humans. Previous studies have established that drugs affect EEG characteristics in humans and rodents in a similar manner. However, there has been little work to establish correlations between drug effects on behavioral and EEG characteristics in rats. In the current study, we have simultaneously monitored EEG characteristics during a novel object recognition task (NORT) or open field (OF) test in rats...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29068793/use-of-fast-scan-cyclic-voltammetry-to-assess-phasic-dopamine-release-in-rat-models-of-early-postpartum-maternal-behavior-and-neglect
#19
Tatiana A Shnitko, Kyla D Mace, Kaitlin M Sullivan, W Kyle Martin, Elizabeth H Andersen, Sarah K Williams Avram, Josephine M Johns, Donita L Robinson
Maternal behavior (MB) is a complex response to infant cues, orchestrated by postpartum neurophysiology. Although mesolimbic dopamine contributes toward MB, little is known about real-time dopamine fluctuations during the postpartum period. Thus, we used fast-scan cyclic voltammetry to measure individual dopamine transients in the nucleus accumbens of early postpartum rats and compared them with dopamine transients in virgins and in postpartum females exposed to cocaine during pregnancy, which is known to disrupt MB...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29064843/touchscreen-technology-in-the-study-of-cognition-related-behavior
#20
Brian D Kangas, Jack Bergman
There is a growing need for new translational animal models designed to capture complex behavioral phenotypes implicated in addiction and other neuropsychiatric conditions. For example, a complete understanding of the effects of commonly abused drugs, as well as candidate medications, requires assessments of their effects on learning, memory, attention, and other cognition-related behavior. Modern touch-sensitive technology provides an extremely flexible means to expose an experimental subject to a variety of complex behavioral tasks designed to assay dimensions of cognitive function before, during, and after drug administration...
December 2017: Behavioural Pharmacology
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