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Behavioural Pharmacology

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https://www.readbyqxmd.com/read/29683809/role-of-d1-like-and-d2-like-dopamine-receptors-within-the-ventral-tegmental-area-in-stress-induced-and-drug-priming-induced-reinstatement-of-morphine-seeking-in-rats
#1
Sharareh Farahimanesh, Marzieh Moradi, Farzaneh Nazari-Serenjeh, Shahram Zarrabian, Abbas Haghparast
The ventral tegmental area (VTA) as a major source of dopamine neurons projecting to cortical and limbic regions has a crucial role in reward as well as stress processes. Dopamine is a predominant neurotransmitter in the reward system, which plays an important role in both drug priming-induced and cue-induced reinstatement of cocaine and heroin seeking. It has been shown that this neurotransmitter has a role in stress-induced relapse to drug seeking. Therefore, the present study aims to evaluate the effects of intra-VTA administration of SCH-23390, as a dopamine D1-like receptor antagonist, and sulpiride, as a dopamine D2-like receptor antagonist, on drug priming-induced and food deprivation (FD)-induced reinstatement...
April 20, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29664745/cross-tolerance-between-nitric-oxide-synthase-inhibition-and-atypical-antipsychotics-modify-nicotinamide-adenine-dinucleotide-phosphate-diaphorase-activity-in-mouse-lateral-striatum
#2
Sonia G Prieto, João C S Silva, Mairon O de Lima, Maria C Almeida, Marcela B Echeverry
Previous research indicates that the subchronic administration of NG-nitro-L-arginine (L-NOARG) produces tolerance to haloperidol-induced catalepsy in Swiss mice. The present study aimed to further investigate whether intermittent subchronic systemic administration of L-NOARG induces tolerance to the cataleptic effects of haloperidol as well as olanzapine or clozapine (Clz) in C57Bl mice after subchronic administration for 5 consecutive days. Striatal FosB protein expression was measured in an attempt to gain further insights into striatal mechanisms in antipsychotic-induced extrapyramidal symptoms side effects...
April 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29659380/effect-of-pioglitazone-and-simvastatin-in-lipopolysaccharide-induced-amyloidogenesis-and-cognitive-impairment-in-mice-possible-role-of-glutamatergic-pathway-and-oxidative-stress
#3
Sara Thabit, Nesrine S E El Sayed
Neuroinflammation and β-amyloid (Aβ) deposition in the brain are well known characteristics of neurodegeneration. Diabetes and hypercholesterolemia are the main risk factors leading to memory loss and cognitive impairment. Recently, it was found that statins and thiazolidinediones have promising anti-inflammatory and neuroprotective effects that could delay neurodegeneration and neuronal loss in diabetic and hypercholesterolemic patients. The aim of the present study was to investigate the protective effect of simvastatin, pioglitazone, and their combination in lipopolysaccharide (LPS)-induced neuroinflammation and amyloidogenesis...
April 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29634495/a-behavioral-economic-analysis-of-the-value-enhancing-effects-of-nicotine-and-varenicline-and-the-role-of-nicotinic-acetylcholine-receptors-in-male-and-female-rats
#4
Scott T Barrett, Trevor N Geary, Amy N Steiner, Rick A Bevins
Reinforcement value enhancement by nicotine of non-nicotine rewards is believed to partially motivate smoking behavior. Recently, we showed that the value-enhancing effects of nicotine are well characterized by reinforcer demand models and that the value-enhancing effects of the smoking-cessation aid bupropion (Zyban) are distinct from those of nicotine and differ between the sexes. The present study evaluated potential sex differences in the enhancement effects of nicotine and varenicline (Chantix) using a reinforcer demand methodology...
April 9, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29595542/effects-of-daily-morphine-treatment-on-impulsivity-in-rats-responding-under-an-adjusting-stop-signal-reaction-time-task
#5
David R Maguire, Christian Mendiondo, Charles P France
Opioids can enhance delay discounting and premature responding under attentional tasks that might reflect increased impulsivity; although it is not clear whether repeated opioid administration alters behavioral inhibition. Effects of morphine and amphetamine were determined before, during, and after daily morphine administration in rats responding under a stop-signal reaction time task, measuring behavioral inhibition and motor impulsivity. Rats (n=5) completed a two-response sequence to earn food. Occasionally, a tone (stop signal) was presented signifying that food would only be presented if the second response was withheld...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29595541/co-administration-of-amphetamine-with-alcohol-results-in-decreased-alcohol-withdrawal-severity-in-adolescent-rats
#6
Shayna Popkin, Alex Nanchanatt, Madelyn I Mauterer, Dennis E Rhoads
Simultaneous use of stimulants and alcohol is a growing problem, particularly among older adolescents already prone to binge alcohol consumption. Adolescent rats consume high levels of alcohol when administered in a liquid diet and develop a strong alcohol withdrawal syndrome. We exploited this system to administer amphetamine in combination with alcohol and to test the effect of co-administration of amphetamine on alcohol withdrawal-induced hypoactivity and overall withdrawal severity. The presence of dietary amphetamine (≤40 mg/l) had no effect on consumption of control or alcohol-containing diets...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29595540/sex-specific-differences-in-cannabinoid-induced-extracellular-signal-regulated-kinase-phosphorylation-in-the-cingulate-cortex-prefrontal-cortex-and-nucleus-accumbens-of-lister-hooded-rats
#7
Michela Rosas, Simona Porru, Valentina Giugliano, Silvia Antinori, Simona Scheggi, Paola Fadda, Walter Fratta, Elio Acquas, Liana Fattore
Sex-dependent differences have been consistently described in cannabinoid addiction research. In particular, we recently reported that female Lister Hooded rats display greater self-administration of the cannabinoid CB1 receptor agonist WIN55,212-2 (WIN) and stronger reinstatement of cannabinoid-seeking behavior than males. Cannabinoids modulate the phosphorylation of the extracellular-signal-regulated kinase (ERK) pathway, leading to various forms of plasticity-related learning that likely affect operant behavior...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29595539/repeated-forced-swimming-test-in-intact-female-rats-behaviour-oestrous-cycle-and-enriched-environment
#8
Karolina Domingues, Inaê Spezia, Lais C Theindl, Patrick R Suman, Fernanda B Lima, Cilene Lino de Oliveira
Psychopharmacology used animal models to study the effects of drugs on brain and behaviour. The repeated forced-swimming test (rFST), which is used to assess the gradual effects of antidepressants on rat behaviour, was standardized only in males. Because of the known sex differences in rats, experimental conditions standardized for males may not apply to female rats. Therefore, the present work aimed to standardize experimental and housing conditions for the rFST in female rats. Young or adult Wistar female rats were housed in standard or enriched environments for different experimental periods...
March 27, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29570114/fatty-acid-binding-proteins-5-and-7-gene-deletion-increases-sucrose-consumption-and-diminishes-forced-swim-immobility-time
#9
John Hamilton, Christopher Koumas, Brendan H Clavin, Matthew Marion, Antonio Figueiredo, Steve Gonzalez, Joseph R O'Rourke, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thanos
Inhibition and genetic deletion of fatty acid-binding proteins (FABPs) 5 and 7 have been shown to increase the levels of the endocannabinoid anandamide as well as the related N-acylethanolamine's palmitoylethanolamide and oleoylethanolamide. This study examined the role of these FABPs on forced-swim (FS) behavior and on sucrose consumption in two experiments: (experiment 1) using wild-type (WT) mice treated with the FABP inhibitor SBFI26 or vehicle and (experiment 2) using WT and FABP5/7 deficient mice. Results from experiment 1 showed that acute treatment with SBFI26 did not have any effect on sucrose intake or FS behavior in mice...
March 21, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29570113/potential-learning-and-memory-disruptors-and-enhancers-in-a-simple-1-day-operant-task-in-mice
#10
Rajesh K K Sanku, Joel S John, Matthew Salkovitz, Marc A Ilies, Ellen A Walker
The objective of this study was to develop a rapid, 1-day learning and memory assay in mice that is sensitive to the effects of compounds that could impair or enhance acquisition and retrieval. Swiss-Webster, male mice were placed in experimental chambers for a 1-h acquisition session with an intermittent, audible tone. If a nose-poke response occurred during the tone, an Ensure water solution was presented. After 1 h, the mice returned to the chambers for 2 h. Drugs were injected before or after sessions to determine the effects on acquisition and/or retrieval...
March 21, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29561292/behavioral-effects-of-toll-like-receptor-4-antagonist-eritoran-in-an-experimental-model-of-depression-role-of-prefrontal-and-hippocampal-neurogenesis-and-%C3%AE-aminobutyric-acid-glutamate-balance
#11
Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghanem
Depression is the disease of the modern era. The lack of response to the available antidepressants, which were developed on the basis of the monoaminergic deficit hypothesis of depression, has encouraged scientists to think about new mechanisms explaining the pathogenesis of depression. In this context, the inflammatory theory has emerged to clarify many aspects of depression that the previous theories have failed to explain. Toll-like receptor-4 (TLR-4) has a regulatory role in the brain's immune response to stress, and its activation is suggested to play a pivotal role in the pathophysiology of depression...
March 20, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29561291/perinatal-exposure-to-venlafaxine-leads-to-lower-anxiety-and-depression-like-behavior-in-the-adult-rat-offspring
#12
Eszter Bogi, Kristina Belovicová, Eduard Ujhazy, Mojmír Mach, Romana Koprdova, Ludmila Zilava, Alexandra Garafová, Daniela Jezova, Michal Dubovicky
Depression during pregnancy and in the post-partum period is a growing health issue. Venlafaxine, a representative of serotonin and noradrenaline reuptake inhibitors, is used to treat a wide spectrum of mood disorders. However, the limited number of prenatal and perinatal studies raises the question about the long-term consequences of venlafaxine therapy. The aim of this study was to investigate the effect of venlafaxine exposure during pregnancy and lactation on anxiety-like and depression-like behaviors, as well as adrenocortical hormone concentrations in the adult rat offspring...
March 20, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29561290/pilot-investigation-randomized-controlled-analog-trial-for-alcohol-and-tobacco-smoking-co-addiction-using-contingency-management
#13
Michael F Orr, Crystal Lederhos Smith, Myles Finlay, Samantha C Martin, Olivia Brooks, Oladunni A Oluwoye, Emily Leickly, Michael McDonell, Ekaterina Burduli, Celestina Barbosa-Leiker, Matt Layton, John M Roll, Sterling M McPherson
Contingency management (CM) is associated with decreases in off-target drug and alcohol use during primary target treatment. The primary hypothesis for this trial was that targeting alcohol use or tobacco smoking would yield increased abstinence in the opposite, nontargeted drug. We used a 2 [CM vs. noncontingent control (NC) for alcohol]×2 (CM vs. NC for smoking tobacco) factorial design, with alcohol intake (through urinary ethyl glucuronide) and tobacco smoking (through urinary cotinine) as the primary outcomes...
March 20, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29543609/acute-food-deprivation-separates-motor-activating-from-anxiolytic-effects-of-caffeine-in-a-rat-open-field-test-model
#14
Daniela Schulz
Similar doses of caffeine have been shown to produce either anxiolytic or anxiogenic effects in rats. The reasons for these conflicting results are not known. We hypothesized that food deprivation stress interacts with the stimulant effects of caffeine to increase anxiety-like behavior. We tested 32 female Sprague Dawley rats in a dim open field for 10 min. Half of the animals were food deprived for 24 h and injected (intraperitoneal) with caffeine (30 mg/kg; n=7) or deionized water (n=8) 20 min before the open field test...
March 14, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29537989/psilocin-and-ketamine-microdosing-effects-of-subchronic-intermittent-microdoses-in-the-elevated-plus-maze-in-male-wistar-rats
#15
Rachel R Horsley, Tomáš Páleníček, Jan Kolin, Karel Valeš
Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent 'microdosing' (usually one-tenth of a 'full' active dose), with reports of long-lasting relief from anxiety and related disorders; however, there is no scientific evidence for the efficacy of therapeutic microdosing nor to show its lasting effects. The objective of this study was to test for lasting effects on anxiety in rats after microdosing with ketamine or psilocin...
March 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29537988/effects-on-brain-derived-neurotrophic-factor-signalling-of-chronic-mild-stress-chronic-risperidone-and-acute-intracranial-dopamine-receptor-challenges
#16
Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Ewa Litwa, Monika Niemczyk, Katarzyna Tota-Glowczyk, Agata Faron-Gorecka, Maciej Kusmider, Joanna Solich, Marta Szlachta, Paul Willner
We have previously reported the effects of intracranial injections of dopamine D1, D2 and D3 ligands in animals subjected to the Novel Object Recognition (NOR) test following exposure to chronic mild stress (CMS) and chronic treatment with risperidone (RSP). Here, we present some molecular biological data from the same animals. It was predicted that brain-derived neurotrophic factor (BDNF) signalling in the prefrontal cortex (PFC) would reflect behavioural performance, implying an increase following acute administration of a D2 agonist or a D3 antagonist, blockade of this effect by CMS and its restoration by chronic RSP...
March 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29521667/estradiol-suppresses-ingestive-response-evoked-by-activation-of-5-ht1a-receptors-in-the-lateral-hypothalamus-of-ovariectomized-rats
#17
Ana P D Taschetto, Brunno R Levone, Larissa Kochenborger, Eduardo S da Silva, Rafael A Flores, Moacir S Faria, Marta A Paschoalini
The present study investigated the effects of estradiol (E2) on ingestive behavior after activation of 5-HT1A receptors in the lateral hypothalamus (LH) of female rats habituated to eat a wet mash diet. Ovariectomized rats treated with corn oil (OVX) or estradiol cypionate (OVX+E) received local injections into the LH of vehicle or an agonist of 5-HT1A receptors, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT; at a dose of 6 nmol). To determine the involvement of these receptors in food intake, some animals were pretreated with N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide maleate (WAY-100635, a 5-HT1A receptor full antagonist, at a dose of 0...
March 8, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461983/corticosterone-impairs-flexible-adjustment-of-spatial-navigation-in-an-associative-place-reward-learning-task
#18
Silviu I Rusu, Jan V Lankelma, Jadin C Jackson, Laura A Van Mourik-Donga, Marian Joëls, Cyriel M A Pennartz
Cognitive challenges are often accompanied by a discharge of stress hormones, which in turn modulate multiple brain areas. Among these, the medial temporal lobe and the prefrontal cortex are critically involved in high-order cognitive functions such as learning, memory, and decision-making. Previous studies assessing the effects of corticosterone on spatial memory found an increase or a decrease in performance depending on the timing of stress hormone discharge relative to the behavioral task. Most of these studies, however, made use of aversively motivated behaviors, whereas less is known about corticosteroid effects on flexible learning during reward-driven spatial navigation...
June 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29543652/exposure-to-opiates-in-male-adolescent-rats-alters-pain-perception-in-the-male-offspring
#19
Narges Pachenari, Hossein Azizi, Elmira Ghasemi, Maryam Azadi, Saeed Semnanian
During the past decades, the use/misuse of opioids has increased dramatically among adolescent population. It is now well acknowledged that various morphological and physiological changes occur in the brain during adolescence. During this critical period, brain development and maturation could be affected by several factors including stress, drug abuse, nutritional status, etc. Although studies on transgenerational effects of substances such as alcohol, nicotine, and cocaine have focused on both paternal and maternal drug exposure, most reports on transgenerational effects of morphine are restricted to maternal exposure...
April 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29543651/early-signs-of-colonic-inflammation-intestinal-dysfunction-and-olfactory-impairments-in-the-rotenone-induced-mouse-model-of-parkinson-s-disease
#20
Lívia H Morais, Daniela B Hara, Maíra A Bicca, Anicleto Poli, Reinaldo N Takahashi
The factors that trigger the pathophysiology of Parkinson's disease (PD) are unknown. However, it is suggested that environmental factors, such as exposure to pesticides, play an important role, in addition to genetic predisposition and aging. Early signs of PD can appear in the gastrointestinal (GI) tract and in the olfactory system, preceding the onset of motor impairments by many years. The present study assessed the effects of oral rotenone administration (30 mg/kg) in inducing GI and olfactory dysfunctions associated with PD in mice...
April 2018: Behavioural Pharmacology
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