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Journal of Nephrology

Paul A Devine, Aisling E Courtney, Alexander P Maxwell
Successful kidney transplantation offers patients with end-stage renal disease the greatest likelihood of survival. However, cardiovascular disease poses a major threat to both graft and patient survival in this cohort. Transplant recipients are unique in their accumulation of a wide range of traditional and non-traditional cardiovascular risk factors. Hypertension, diabetes, dyslipidaemia and obesity are highly prevalent in patients with end-stage renal disease. These risk factors persist following transplantation and are often exacerbated by the drugs used for immunosuppression in organ transplantation...
November 7, 2018: Journal of Nephrology
Abduzhappar Gaipov, Zhannat Taubaldiyeva, Manarbek Askarov, Zaiyrkhan Turebekov, Larisa Kozina, Askhat Myngbay, Olga Ulyanova, Saltanat Tuganbekova
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Previous studies demonstrated safety and efficacy of autologous bone marrow-derived mononuclear cells (ABM-MNCs) in induced type-1 diabetes mellitus (T1DM) rats. However, the effect of ABM-MNCs on urinary markers of DN in humans is not well studied. We evaluated the therapeutic effect of ABM-MNCs on the urinary markers microalbuminuria (MAU), urinary type-IV collagen and urinary neutrophil gelatinase-associated lipocalin (uNGAL) in T1DM patients with and without nephropathy...
November 7, 2018: Journal of Nephrology
Angela Volpi, Gabriele Sala, Elena Lesma, Francesca Labriola, Marco Righetti, Rosa Maria Alfano, Mario Cozzolino
Tuberous sclerosis complex (TSC) is a complex disease with many different clinical manifestations. Despite the common opinion that TSC is a rare condition, with a mean incidence of 1/6000 live births and a prevalence of 1/20,000, it is increasingly evident that in reality this is not true. Its clinical sequelae span a range of multiple organ systems, in particular the central nervous system, kidneys, skin and lungs. The management of TSC patients is heavily burdensome in terms of time and healthcare costs both for the families and for the healthcare system...
November 7, 2018: Journal of Nephrology
Ze Wang, Tao Cui, Xiaoyan Ci, Fang Zhao, Yinghui Sun, Yazhuo Li, Rui Liu, Weidang Wu, Xiulin Yi, Changxiao Liu
The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. One of them is transporters which are responsible for the debouchment of uric acid within blood. The transport and excretion of uric acid is a complicated procedure which is related with various transporters such as OAT1, OAT3, OAT4, URAT1, GLUT9, BCRP, MRP4, NPT1, NTP4, and so on...
October 31, 2018: Journal of Nephrology
Masahiko Oguro, Yuta Kogure, Junichi Hoshino, Yoshifumi Ubara, Hiroki Mizuno, Akinari Sekine, Masahiro Kawada, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Naoki Sawa, Kenmei Takaichi
BACKGROUND: A recent study demonstrated that tolvaptan slowed estimated glomerular filtration rate (eGFR) decline in later-stage autosomal dominant polycystic kidney disease (ADPKD) patients. However, Japanese patients were not included in that trial, therefore tolvaptan's efficacy in Japanese patients with advanced chronic kidney disease (CKD) has remained unknown. METHODS: In this prospective cohort study, 54 patients with ADPKD who had eGFR ≥ 15 ml/min/1...
October 24, 2018: Journal of Nephrology
Linlin Sun, Yongqiang Ji, Yonglan Wang, Miao Ding, Xinmiao Xie, Dingyu Zhu, Fuhua Chen, Nan Zhang, Xiaoxia Wang
OBJECTIVE: To identify the relationship between serum high-sensitive cardiac troponin T (hs-cTnT) and left ventricular diastolic dysfunction (LVDD) among maintenance hemodialysis patients and to further explore the value of hs-cTnT in evaluating and predicting LVDD in this special group of patients. METHODS: In a cross-sectional study, 152 dialysis patients with end-stage renal disease (ESRD) underwent Hs-cTnT measurement using the high sensitivity assay. Echocardiography measurements were carried out according to the American Society of Echocardiography recommendations and E/E' > 15 or E' < 7 cm/s was defined as diastolic dysfunction...
October 22, 2018: Journal of Nephrology
Serena Yen Shan Tan, Richard Kent Sibley, Sharina Belani, Sumie Iwasaki, Leonid Yankulin, Tracy Jonelis, John Patrick Twistington Higgins, Neeraja Kambham, Megan Leigh Troxell
IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies...
October 17, 2018: Journal of Nephrology
Dejan Lavrek, Sebastiano A G Lava, Gregorio P Milani, Giacomo D Simonetti, Mario G Bianchetti, Olivier Giannini
BACKGROUND: Intestinal infections caused by a shigatoxin-positive Escherichia coli (mostly of the serogroups O26, O45, O103, O111, O121, O145 and especially O157) are a common cause of hemolytic-uremic syndrome. Hemolytic-uremic syndrome was first linked with an E. coli urinary tract infection 40 years ago. METHODS: We conducted a systematic review of the literature addressing the association between E. coli urinary tract infection and hemolytic-uremic syndrome...
October 17, 2018: Journal of Nephrology
Nicholas I Cole, Rebecca J Suckling, Vipula Desilva, Feng J He, Graham A MacGregor, Pauline A Swift
BACKGROUND: Higher serum sodium concentration has been reported to be a risk factor for the development of incident chronic kidney disease (CKD), but its relationship with the progression of established CKD has not been investigated. We hypothesised that increased serum sodium concentration is a risk factor for estimated glomerular filtration rate (eGFR) decline in CKD. METHODS: This was a retrospective cohort study using data collected over a 6-year period, with baseline data obtained during the first 2 years...
October 16, 2018: Journal of Nephrology
Giovanni M Frascà, Fabiana Brigante, Alessandro Volpe, Laura Cosmai, Maurizio Gallieni, Camillo Porta
Due to the increasing occurrence of renal cell carcinoma (RCC) in the general population and the high prevalence of chronic kidney disease among cancer patients, many people with a previous RCC may eventually require renal replacement therapy including kidney transplantation. They should accordingly be evaluated to assess their life expectancy and the risk that the chronic immunosuppressive therapy needed after grafting might impair their long-term outcome. Current guidelines on listing patients for renal transplantation suggest that no delay is required for subjects with small or incidentally discovered RCC, while the recommendations for patients who have been treated for a symptomatic RCC or for those with large or invasive tumours are conflicting...
October 16, 2018: Journal of Nephrology
Sebastian J Klein, Georg F Lehner, Lui G Forni, Michael Joannidis
Oliguria is often observed in critically ill patients. However, different thresholds in urine output (UO) have raised discussion as to the clinical importance of a transiently reduced UO of less than 0.5 ml/kg/h lasting for at least 6 h. While some studies have demonstrated that isolated oliguria without a concomitant increase in serum creatinine is associated with higher mortality rates, different underlying pathophysiological mechanisms suggest varied clinical importance of reduced UO, as some episodes of oliguria may be fully reversible...
October 8, 2018: Journal of Nephrology
Fabrizio Grosjean, Mara De Amici, Catherine Klersy, Gianluca Marchi, Antonio Sciortino, Federica Spaltini, Maurizio Pin, Valentina Grazioli, Anna Celentano, Benedetta Vanini, Giorgia Testa, Vincenzo Sepe, Teresa Rampino, Andrea Maria D'Armini
OBJECTIVES: The only curative treatment for chronic thromboembolic pulmonary hypertension (CTEPH) is pulmonary endarterectomy (PEA). PEA requires cardiopulmonary bypass (CPB) which is associated with a high acute kidney injury (AKI) risk. Circulating endothelin-1 (ET-1) levels are elevated in CTEPH, and ET-1 plays a pivotal role in AKI. Because AKI is burdened by high morbidity and mortality, we aimed to evaluate the association between preoperative ET-1 and the risk to develop AKI in CTEPH individuals who undergo PEA...
September 18, 2018: Journal of Nephrology
Nicolás Roberto Robles, Francesco Fici, Guido Grassi
Aggressive reduction of blood pressure (BP) may increase cardiovascular events (the J-curve phenomenon) in certain populations. There is a high number of available studies of antihypertensive treatment that provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main cardiovascular outcomes. Nonetheless, most available studies were observational, and randomized trials might not have or lost their statistical power in post-hoc analysis. Contrariwise, most of prospective trial to demonstrate the benefits of intensive blood pressure control were inconclusive...
September 17, 2018: Journal of Nephrology
Filippo Mariano, Marta Leporati, Paola Carignano, Maurizio Stella, Marco Vincenti, Luigi Biancone
BACKGROUND: This study assessed the contribution of intracorporeal (IC) and extracorporeal clearance (EC) of furosemide in patients with septic acute kidney injury (AKI), and the relationship between plasma concentrations and urine volume. METHODS: Prospective cohort observational study of 15 patients with septic AKI undergoing continuous veno-venous hemodiafiltration (CVVHDF) divided according to urine volume (< 500 ml/12 h, Oliguria group, n = 5; > 500 ml/12 h, Diuresis group, n = 10) during continuous infusion of furosemide (120 mg/12 h) at steady-state condition...
September 17, 2018: Journal of Nephrology
Alfredo Leaños-Miranda, Inova Campos-Galicia, Karla Leticia Ramírez-Valenzuela, María Guadalupe Berumen-Lechuga, Irma Isordia-Salas, Carlos José Molina-Pérez
OBJECTIVE: Chronic kidney disease (CKD) pregnancies are at high risk of developing adverse outcomes. In non-pregnant subjects with CKD, higher urinary IgM levels are associated with poor renal survival and higher rates of cardiovascular deaths. In this study, we assessed whether urinary IgM levels are associated with an increased risk of adverse pregnancy outcomes (APO) in CKD pregnancies. METHODS: We performed a nested case-control study within a cohort of CKD patients with singleton pregnancies attended at a tertiary care hospital...
September 11, 2018: Journal of Nephrology
Ilaria Petrucci, Anna Clementi, Concetto Sessa, Irene Torrisi, Mario Meola
Chronic kidney disease (CKD) includes all clinical features and complications during the progression of various kidney conditions towards end-stage renal disease (ESRD). These conditions include immune and inflammatory disease such as: primary and hepatitis C virus (HCV)-related glomerulonephritis; infectious disease such as pyelonephritis with or without reflux and tuberculosis; vascular disease such as chronic ischemic nephropathy; hereditary and congenital disease such as polycystic disease and congenital cystic dysplasia; metabolic disease including diabetes and hyperuricemia; and systemic disease (collagen disease, vasculitis, myeloma)...
September 6, 2018: Journal of Nephrology
Marilina Tampoia, Francesca Migliucci, Chiara Villani, Letizia Abbracciavento, Michele Rossini, Ruggiero Fumarulo, Loreto Gesualdo, Vincenzo Montinaro
Autoantibodies against phospholipase A2 receptor (PLA2R) are a sensitive and specific marker for idiopathic membranous nephropathy (IMN). The aim of our study was to redefine the cut-off value for the measurement of anti-PLA2R autoantibody levels by an automated enzyme immunoassay, in a large single-center cohort of Italian IMN patients at the time of diagnosis. Sixty-seven consecutive incident patients, with biopsy-proven IMN, were recruited. All patients were naïve to preceding immunosuppressive therapeutic regimens...
September 5, 2018: Journal of Nephrology
Maharajan Raman, Darren Green, Rachel J Middleton, Philip A Kalra
BACKGROUND: In older patients with chronic kidney disease (CKD), the risk of progression to end stage renal disease and cardiovascular death both differ compared to younger patients. This likely reflects differences in case mix and co-morbid burdens. We sought to establish the extent to which age itself is an independent biomarker of adverse outcome in CKD. METHODS: This was an analysis of the Salford Kidney Study, a prospective, longitudinal, observational study of 2,667 patients with eGFR < 60 ml/min/1...
September 5, 2018: Journal of Nephrology
Sen Kan, Weichen Zhang, Jianping Mao, Mengjing Wang, Li Ni, Minmin Zhang, Qian Zhang, Jing Chen
BACKGROUND: Secondary hyperparathyroidism is characterized by parathyroid gland (PG) hyperplasia, and excessive synthesis and secretion of parathyroid hormone (PTH). Reduced vitamin D receptor (VDR) density has shown to play an essential role in PG hyperplasia progression; nevertheless, its exact mechanism remains unclear. VDR has shown to suppress the inflammation mediator NF-κB-mediated gene transcription. The aim of this study is to examine whether NF-κB is involved in the pathogenesis of parathyroid hyperplasia...
August 31, 2018: Journal of Nephrology
Laura Sarno, Antonella Tufano, Giuseppe Maria Maruotti, Pasquale Martinelli, Mario M Balletta, Domenico Russo
Pregnancy can be a dangerous trigger for patients with paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), or hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome. Due to the possibility of several serious complications, pregnancy is somewhat discouraged in the presence of the above diseases. Eculizumab is a humanized antibody that may dramatically change the clinical course of PNH, aHUS and HELLP syndrome. However, data on the safety of eculizumab in pregnancy are scarce...
August 29, 2018: Journal of Nephrology
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