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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#1
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29776717/m2-macrophages-promote-wound-induced-hair-neogenesis
#2
Akira Kasuya, Taisuke Ito, Yoshiki Tokura
BACKGROUND: De novo hair regeneration occurs in scars of normal adult mice. This interesting phenomenon is termed as wound-induced hair neogenesis (WIHN). We hypothesized that M2 macrophages are crucially involved in WIHN. OBJECTIVE: To clarify the contribution of M2 macrophages to WIHN. METHOD: We established a mouse model of WIHN. A full thickness skin excision was implemented on the back of C57BL/6 (B6) mice. Newly developing hair follicles were detected by a whole-mount assay...
May 12, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29764717/mitochondrial-damage-and-cytoskeleton-reorganization-in-human-dermal-fibroblasts-exposed-to-artificial-visible-light-similar-to-screen-emitted-light
#3
Adeline Rascalou, Jérôme Lamartine, Pauline Poydenot, Frédéric Demarne, Nicolas Bechetoille
BACKGROUND: Artificial visible light is everywhere in modern life. Social communication confronts us with screens of all kinds, and their use is on the rise. We are therefore increasingly exposed to artificial visible light, the effects of which on skin are poorly known. OBJECTIVE: The purpose of this study was to model the artificial visible light emitted by electronic devices and assess its effect on normal human fibroblasts. METHODS: The spectral irradiance emitted by electronic devices was optically measured and equipment was developed to accurately reproduce such artificial visible light...
May 5, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29789228/distinct-kinetics-of-two-pathologies-induced-in-mice-by-topical-treatment-with-imiquimod-cream-psoriasis-like-inflammation-and-systemic-autoimmunity
#4
LETTER
Sayo Kataoka, Mayuko Yamamoto, Kentaro Ohko, Kimiko Nakajima, Shigetoshi Sano
No abstract text is available yet for this article.
May 4, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29752146/a-novel-topical-nonsteroidal-trpv1-antagonist-pac-14028-cream-improves-skin-barrier-function-and-exerts-anti-inflammatory-action-through-modulating-epidermal-differentiation-markers-and-suppressing-th2-cytokines-in-atopic-dermatitis
#5
Ji-Hae Lee, Chang Soon Choi, Il-Hong Bae, Jin Kyu Choi, Young-Ho Park, Miyoung Park
BACKGROUND: Although it is established that epidermal barrier disturbance and immune dysfunction resulting in IgE sensitization are critical factors in the development of cutaneous inflammation, the pathogenesis and targeted therapy of atopic dermatitis (AD)-specific pathways have still been unknown. OBJECTIVE: Taking into account the fact that Th2 cytokines in AD have both unique and overlapping functions including increased epidermal thickening, inflammation, and decreased expressing of the barrier proteins keratinocyte differentiation, we sought to clarify our hypothesis that TRPV1 antagonist plays a critical role in skin barrier function and can be a therapeutic target for AD...
April 30, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29731195/urban-particulate-matter-in-air-pollution-penetrates-into-the-barrier-disrupted-skin-and-produces-ros-dependent-cutaneous-inflammatory-response-in-vivo
#6
Seon-Pil Jin, Zhenyu Li, Eun Kyung Choi, Serah Lee, Yoen Kyung Kim, Eun Young Seo, Jin Ho Chung, Soyun Cho
BACKGROUND: Particulate matter (PM) is an integral part of air pollution, which is a mixture of particles suspended in the air. Recently, it has been reported that PM is associated with increased risks of skin diseases, especially atopic dermatitis in children. However, it is unclear if PM directly goes into the skin and what mechanisms are involved in response to PM. OBJECTIVE: To see whether PM could penetrate into the barrier-disrupted skin, produce reactive oxygen species (ROS), and elicit an inflammatory response...
April 30, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29731194/lipoxin-a4-inhibits-uv-radiation-induced-skin-inflammation-and-oxidative-stress-in-mice
#7
R M Martinez, V Fattori, P Saito, C B P Melo, S M Borghi, I C Pinto, A J C Bussmann, M M Baracat, S R Georgetti, W A Verri, R Casagrande
BACKGROUND: Lipoxin A4 (LXA4 ) is a metabolic product of arachidonic acid. Despite potent anti-inflammatory and pro-resolution activities, it remains to be determined if LXA4 has effect on ultraviolet (UV) radiation-induced skin inflammation. OBJECTIVE: To investigate the effects of systemic administration with LXA4 on UV radiation-induced inflammation and oxidative damage in the skin of mice. METHODS: Varied parameters of inflammation and oxidative stress in the skin of mice were evaluated after UV radiation (4...
April 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29730172/glycyrrhiza-flavonoids-and-its-major-component-licochalcone-a-inhibit-melanogenesis-through-mapk-erk-pathway-by-activating-erk-phosphorylation
#8
LETTER
Jun-Hui Hong, Si-Wei Cao, Shi-Jian Xiang, Shi-Fa Ruan, Bai-Chao An, Zhu-Xian Wang, Wen-Feng Wu, Huo-Ji Chen, Li-Dong Weng, Lu Zhang, Li Liu, Yu-Yao Chen, Qun Shen, Hong-Xia Zhu, Qiang Liu
No abstract text is available yet for this article.
April 26, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29730173/bepotastine-besilate-downregulates-the-expression-of-nerve-elongation-factors-in-normal-human-epidermal-keratinocytes
#9
LETTER
Yayoi Kamata, Azumi Sakaguchi, Yoshie Umehara, Yasushi Suga, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
No abstract text is available yet for this article.
April 23, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29706245/non-invasive-bioluminescence-imaging-as-a-standardized-assessment-measure-in-mouse-models-of-dermal-inflammation
#10
Martine Catharina Josephine Hofmann, Mike Schmidt, Olga Arne, Gerd Geisslinger, Michael John Parnham, Natasja Maria Wilhelmina Johanna de Bruin
BACKGROUND: Myeloperoxidase is used as a marker and diagnostic tool for inflammatory processes. Hypochlorous acid produced by myeloperoxidase oxidizes luminol to produce light. By injecting luminol into experimental animals, inflammatory processes can be tracked in real-time by bioluminescence imaging (BLI). OBJECTIVE: We aimed to establish BLI as a standardized assessment measure in three mouse models of dermal inflammation. METHODS: Oxazolone-induced delayed-type-hypersensitivity (DTH) (acute), a model for dermatitis, imiquimod (IMQ) (sub-chronic) model for psoriasis and the (chronic) bleomycin model for scleroderma were used...
April 23, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29735364/methyl-2-acetylamino-3-4-hydroxyl-3-5-dimethoxybenzoylthio-propanoate-suppresses-melanogenesis-through-erk-signaling-pathway-mediated-mitf-proteasomal-degradation
#11
Ji Hoon Ha, Yoon Ju Jeong, Song Hua Xuan, Jae-Young Lee, Jino Park, Soo Nam Park
BACKGROUND: Microphthalmia-associated transcription factor (MITF) is regulated by expression and/or degradation pathway, controlling to the expression of melanogenic enzymes for melanin synthesis. Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate (MAHDP) is reported to anti-melanogenesis effect but its mechanism remain unclear. OBJECTIVE: To investigate the effects of MAHDP on melanogenesis and elucidate its mechanism. METHODS: Tyrosinase activity, melanogenic proteins and gene expression levels were measured with MAHDP treatment in B16F1 cells, human melanocytes, reconstructed skin and clinical trial...
April 22, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29703420/tryptophan-photo-product-ficz-upregulates-ahr-mek-erk-mediated-mmp1-expression-implications-in-anti-fibrotic-phototherapy
#12
Mika Murai, Kazuhiko Yamamura, Akiko Hashimoto-Hachiya, Gaku Tsuji, Masutaka Furue, Chikage Mitoma
BACKGROUND: Scleroderma is caused by aberrant transforming growth factor-ß signaling. The degradation of extracellular matrix proteins is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Ultraviolet (UV) radiation has been a therapy for scleroderma. 6-Formylindolo[3,2-b]carbazole (FICZ), an endogenous aryl hydrocarbon receptor (AHR) ligand, is a tryptophan metabolite generated by UV exposure. Nonetheless, whether FICZ regulates MMPs and TIMPs has not been investigated...
April 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29691121/stabilization-of-microtubules-restores-barrier-function-after-cytokine-induced-defects-in-reconstructed-human-epidermis
#13
Chiung-Yueh Hsu, Nicolas Lecland, Valérie Pendaries, Cécile Viodé, Daniel Redoulès, Carle Paul, Andreas Merdes, Michel Simon, Christiane Bierkamp
BACKGROUND: A variety of human skin disorders is characterized by defects in the epidermal barrier, leading to dehydration, itchiness, and rashes. Previously published literature suggests that microtubule stabilization at the cortex of differentiating keratinocytes is necessary for the formation of the epidermal barrier. OBJECTIVES: We tested whether stabilization of microtubules with paclitaxel or epothilone B can repair barrier defects that were experimentally induced in three-dimensional culture models of epidermis...
April 18, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29678305/the-effect-of-cilostazol-a-phosphodiesterase-3-pde3-inhibitor-on-human-hair-growth-with-the-dual-promoting-mechanisms
#14
Hye-In Choi, Dong Young Kim, Soon-Jin Choi, Chang-Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown. OBJECTIVE: The purpose of this study was to determine the effect of cilostazol on hair growth. METHODS: We investigated the expression of PDE3 in human dermal papilla cells (DPCs), outer root sheath cells (ORSCs), and hair follicles...
April 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29665991/differential-proteomic-analysis-of-actinic-keratosis-bowen-s-disease-and-cutaneous-squamous-cell-carcinoma-by-label-free-lc-ms-ms
#15
Ali Azimi, Kimberley L Kaufman, Marina Ali, Jonathan Arthur, Steven Kossard, Pablo Fernandez-Penas
BACKGROUND: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent. OBJECTIVE: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. METHODS: Microdissected formalin-fixed paraffin embedded samples of normal epidermis (n = 4, pooled), AK (n = 10), BD (n = 10) and cSCC (n = 10) were analyzed by mass spectrometry...
April 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29661487/ripk1-downregulation-in-keratinocyte-enhances-trail-signaling-in-psoriasis
#16
Nao Saito, Masaru Honma, Takashi Shibuya, Shin Iinuma, Satomi Igawa, Mari Kishibe, Akemi Ishida-Yamamoto
BACKGROUND: Psoriasis, a common inflammatory skin disorder characterized by scaly erythema and plaques, is induced by dysregulation of dendritic cell- and T cell-mediated immune reaction. Receptor-interacting protein kinase 1 (RIPK1) regulates inflammatory signaling in response to stimuli such as TNF-α, TRAIL, and TLRs, resulting in apoptosis, necroptosis and NF-κB activation. However, the physiological relevance in human epidermis remains elusive. OBJECTIVE: In this study, we examined whether RIPK1 is involved in the pathogenesis of psoriasis vulgaris...
April 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29724581/reversal-of-the-hair-loss-phenotype-by-modulating-the-estradiol-angpt2-axis-in-the-mouse-model-of-female-pattern-hair-loss
#17
Yujiro Endo, Yuko Obayashi, Tomoji Ono, Tetsushi Serizawa, Michiaki Murakoshi, Manabu Ohyama
BACKGROUND: Despite high demand for a remedy, the treatment options for female pattern hair loss (FPHL) are limited. FPHL is frequent in postmenopausal women. In ovariectomized (OVX) mice, which lack β-estradiol (E2) and manifest hair loss mimicking FPHL, E2 supplementation has been shown to increase hair density. However, the mechanism by which E2 exhibits its biological activity remains elusive. OBJECTIVE: To identify the downstream targets of E2 in the context of FPHL pathophysiology and discover a potential therapeutic agent for the E2-dependent subtype of FPHL...
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29685766/influence-of-epidermal-basement-membrane-integrity-on-cutaneous-permeability-barrier-function
#18
LETTER
Shunsuke Iriyama, Yuko Matsuura-Hachiya, Makoto Tsunenaga
No abstract text is available yet for this article.
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29655589/emerging-applications-of-eye-tracking-technology-in-dermatology
#19
REVIEW
Kevin K John, Jakob D Jensen, Andy J King, Manusheela Pokharel, Douglas Grossman
Eye-tracking technology has been used within a multitude of disciplines to provide data linking eye movements to visual processing of various stimuli (i.e., x-rays, situational positioning, printed information, and warnings). Despite the benefits provided by eye-tracking in allowing for the identification and quantification of visual attention, the discipline of dermatology has yet to see broad application of the technology. Notwithstanding dermatologists' heavy reliance upon visual patterns and cues to discriminate between benign and atypical nevi, literature that applies eye-tracking to the study of dermatology is sparse; and literature specific to patient-initiated behaviors, such as skin self-examination (SSE), is largely non-existent...
April 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29655588/resident-and-monocyte-derived-langerhans-cells-are-required-for-imiquimod-induced-psoriasis-like-dermatitis-model
#20
Minseok Lee, Sung Hee Kim, Tae-Gyun Kim, Jeyun Park, Jae Won Lee, Min-Geol Lee
BACKGROUND: Langerhans cells (LCs) are dendritic cells that reside in the epidermis and local inflammation results in an increased differentiation of monocyte-derived LCs. Only few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the results are variable and the exact role of LCs in psoriasis model remains to be elucidated. OBJECTIVE: To explore the functional role of resident (rLCs) and monocyte-derived LCs (mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin-diphtheria toxin subunit A (huLang-DTA) mice...
April 6, 2018: Journal of Dermatological Science
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