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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/28094100/inhibition-of-collagen-production-by-icg-001-a-small-molecule-inhibitor-for-wnt-%C3%AE-catenin-signaling-in-skin-fibroblasts
#1
LETTER
Kyung-Il Kim, Do-Sun Jeong, Tae-Jin Yoon, Eui Chang Jung, Jeung-Hoon Lee, Chang Deok Kim
No abstract text is available yet for this article.
January 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28094099/association-between-1082%C3%A2-a-g-polymorphism-in-il-10-and-oral-lichen-planus-a-meta-analysis
#2
LETTER
Min Qiu, Jiayi Wang, Pengfei He, Hao Xv, Jiao Wei, Wang Gong, Lu Jiang, Qianming Chen
No abstract text is available yet for this article.
January 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28094098/altered-balance-of-epidermis-related-chemokines-in-epidermolysis-bullosa
#3
Inkin Ujiie, Yasuyuki Fujita, Chihiro Nakayama, Wakana Matsumura, Shotaro Suzuki, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu
BACKGROUND: Epidermolysis bullosa (EB) is a congenital, refractory skin disease and there are no fundamental treatments. Recently, allogenic cell therapies are beginning to be applied as potential treatments, that are based on the concept that the allogenic cells can migrate into the skin and reconstitute the skin components. Although the mechanisms of cell migration into skin are not fully understood, chemokines are regarded as key factors in recruiting bone marrow-derived cells. OBJECTIVES: Our study aims to elucidate the expression of chemokines in the EB patients...
January 5, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28089554/synthesis-antioxidant-and-antimelanogenic-activities-of-pegylated-%C3%AE-tocopheryl-lipoate-conjugates
#4
LETTER
Jianmei Ma, Hao Wang, Chenglin Wang, Huanxiang Yuan, Dongsheng Bai, Kyu Yun Chai, Chichong Lu
No abstract text is available yet for this article.
January 5, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28087116/application-of-whole-exome-sequencing-in-elucidating-the-phenotype-and-genotype-spectrum-of-junctional-epidermolysis-bullosa-a-preliminary-experience-of-a-tertiary-care-centre-in-india
#5
Vamsi K Yenamandra, Shamsudheen K Vellarikkal, Manoj Kumar, Madhumita R Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata B Ray, Amit K Dinda, Madhulika Kabra, Punit Kaur, Vinod K Sharma, Gomathy Sethuraman
BACKGROUND: Junctional epidermolysis bullosa (JEB) is a diverse group of genodermatoses associated with extreme skin fragility. Despite several well-characterized genetic studies, molecular diagnosis of this heterogeneous group is still challenging. Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing (WES) as a fast and efficient diagnostic strategy in several genodermatoses. OBJECTIVE: In view of the scarcity and need of molecular studies for JEB in India, we sought to explore the potential of WES in understanding the mutational spectrum of this rare, in certain subtypes lethal, sub-group of EB...
December 29, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28069323/serum-level-of-interleukin-6-is-increased-in-nivolumab-associated-psoriasiform-dermatitis-and-tumor-necrosis-factor-%C3%AE-is-a-biomarker-of-nivolumab-recativity
#6
LETTER
Ryota Tanaka, Naoko Okiyama, Mari Okune, Yosuke Ishitsuka, Rei Watanabe, Junichi Furuta, Mikio Ohtsuka, Atsushi Otsuka, Hiroshi Maruyama, Yasuhiro Fujisawa, Manabu Fujimoto
No abstract text is available yet for this article.
December 29, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28069324/differences-in-therapeutic-effects-of-topically-applied-corticosteroid-and-tacrolimus-on-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#7
Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Kyi Chan Ko, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
BACKGROUND: Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. OBJECTIVE: This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms...
December 24, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28041661/constant-light-exposure-impairs-immune-tolerance-development-in-mice
#8
Hiromi Mizutani, Risa Tamagawa-Mineoka, Yoichi Minami, Kazuhiro Yagita, Norito Katoh
BACKGROUND: An intrinsic daily physiological rhythm called circadian rhythm has been indicated to affect the immune system and its related diseases. Immune tolerance development is closely associated with the onset of immunological disorders. However, the effect of circadian rhythm in the mechanisms of immune tolerance development has not yet been fully understood. OBJECTIVE: The purpose of this study was to investigate the effects of circadian rhythm disruption on the development of immune tolerance by the perturbation of light environment, using a mouse model of neonatally induced cutaneous tolerance...
December 23, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28057405/genetic-variants-associated-with-skin-aging-in-the-chinese-han-population
#9
Wenshan Gao, Jingze Tan, Anke Hüls, Anan Ding, Yu Liu, Mary S Matsui, Andrea Vierkötter, Jean Krutmann, Tamara Schikowski, Li Jin, Sijia Wang
BACKGROUND: The progression and manifestation of human skin aging has a strong genetic basis; however, most of the supporting evidence has been gathered in Caucasian populations. The genetic contribution to the variation in skin aging in non-Caucasian populations is poorly understood. OBJECTIVE: To investigate the genetic risk factors of relevance for skin aging in East Asians, we conducted the first candidate gene study for signs of skin aging in Han Chinese. METHODS: We collected skin aging and genotype data in 502 female Han Chinese from the Taizhou cohort...
December 22, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28034606/treatment-of-hidradenitis-suppurativa-with-intralesional-photodynamic-therapy-with-5-aminolevulinic-acid-and-630nm-laser-beam
#10
María Jesús Suárez Valladares, Noemi Eiris Salvado, Manuel Angel Rodríguez Prieto
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease with multiple treatment options that have been used with mixed results. OBJECTIVES: To evaluate the effectiveness, safety and tolerability of intralesional photodynamic therapy (I-PDT) in the management of HS. Also, to assess the effect of this technique on the different areas treated. METHODS: Case series of 38 HS patients treated with I-PDT between 2011-2015 following a standardized protocol to assess response at the treated areas RESULTS: 29 patients achieved a complete response, while persistence was noted on 8 cases and only 1 suffered a recurrence...
December 19, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28034607/heat-stress-induced-adaptation-in-melanocytes-is-dependent-on-the-level-of-melanin-and-reduction-of-apoptosis
#11
LETTER
Renuka Choudhary, Talla Sridhar Goud, Anil Kumar, Anil K Sharma, Sohan V Singh, Ramesh C Upadhyay, Ashok K Mohanty, Sudarshan Kumar
No abstract text is available yet for this article.
December 15, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28024685/decreases-in-15-lipoxygenase-metabolites-in-olmsted-syndrome-model-rats
#12
Masato Wakabayashi, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, Yasuyuki Igarashi, Akio Kihara
BACKGROUND: Olmsted syndrome (OS) is a congenital dermatosis characterized by palmoplantar keratoderma and periorificial keratotic plaque. TRPV3 (transient receptor potential vanilloid subtype 3) encodes a thermosensitive Ca(2+) channel and is the causative gene of OS. However, the molecular mechanism that causes the pathological development of OS is unclear. OBJECTIVE: We aimed to investigate the molecular mechanisms underlying OS pathology from the perspective of lipid metabolism...
December 15, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28012822/hmgb1-rage-axis-promotes-autophagy-and-protects-keratinocytes-from-ultraviolet-radiation-induced-cell-death
#13
Kuanhou Mou, Wei Liu, Dan Han, Pan Li
BACKGROUND: The primary cause of skin cancer is ultraviolet (UV) light from the sun. Keratinocytes are the predominant cell type in the epidermis and form a barrier against environmental damage, especially from UV light irradiation. Autophagy is a self-digestion mechanism for energy homeostasis at critical times during development and as a response to stress. High-mobility group protein 1 (HMGB1) is a highly conserved nuclear protein that is associated with cell autophagy. OBJECTIVE: We investigated the role of HMGB1 in keratinocytes exposed to UV irradiation and its regulation of keratinocyte autophagy...
December 14, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28063630/clinical-profiles-of-pediatric-patients-with-gpp-alone-and-with-different-il36rn-genotypes
#14
Yirong Wang, Ruhong Cheng, Zhiyong Lu, Yifeng Guo, Ming Yan, Jianying Liang, Peichen Huang, Ming Li, Zhirong Yao
BACKGROUND: IL36RN mutation has been identified as one pathogenesis of generalized pustular psoriasis, but the existence of GPP patients without mutation makes this controversial. OBJECTIVE: Our study aimed at assessing the differences in clinical profiles of children with GPP, with and without IL36RN mutation. METHODS: An ambispective case series study involved review of the records of 66 childhood patients with pediatric-onset GPP and without previous psoriasis vulgaris...
December 13, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28024684/non-pathogenic-pemphigus-foliaceus-pf-igg-acts-synergistically-with-a-directly-pathogenic-pf-igg-to-increase-blistering-by-p38mapk-dependent-desmoglein-1-clustering
#15
Kenji Yoshida, Ken Ishii, Atsushi Shimizu, Mariko Yokouchi, Masayuki Amagai, Ken Shiraishi, Yuji Shirakata, John R Stanley, Akira Ishiko
BACKGROUND: Pemphigus foliaceus (PF) is an autoimmune blistering disease caused by autoantibodies (Abs) against desmoglein 1 (Dsg1). PF sera contain polyclonal Abs which are heterogeneous mixture of both pathogenic and non-pathogenic Abs, as shown by isolation of monoclonal Abs (mAbs). OBJECTIVE: To investigate how pathogenic and non-pathogenic anti-Dsg1 Abs contribute to blister formation in PF. METHODS: Using organ-cultured human skin, we compared the effect of a single pathogenic anti-Dsg1 IgG mAb, a single non-pathogenic anti-Dsg1 IgG mAb, and their mixture on blister formation as analyzed by histology, subcellular localization of IgG deposits and desmosomal proteins by confocal microscopy, and desmosomal structure by electron microscopy...
December 12, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28012821/validation-of-chemiluminescent-enzyme-immunoassay-in-detection-of-autoantibodies-in-pemphigus-and-pemphigoid
#16
Yumi Fujio, Kazuo Kojima, Masahiro Hashiguchi, Masatoshi Wakui, Mitsuru Murata, Masayuki Amagai, Jun Yamagami
BACKGROUND: A novel chemiluminescent enzyme immunoassay (CLEIA) was recently developed to quantify autoantibodies specific for desmogleins (Dsgs) and BP180, the target antigens of pemphigus and pemphigoid. This assay is automated and highly accurate and efficient. OBJECTIVE: To validate the use of the CLEIA for detection of autoantibodies during the clinical courses of patients with pemphigus and pemphigoid. METHODS: To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals...
December 6, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27979585/the-differential-expression-of-protease-activated-receptors-contributes-to-functional-differences-between-dark-and-fair-keratinocytes
#17
Meilang Xue, Haiyan Lin, Ruilong Zhao, Hai Po Helena Liang, Christopher Jackson
BACKGROUND: Dark skin has different properties in comparison to fair skin. Melanocytes have been shown to partly contribute to these differences, however, the involvement of keratinocytes from dark or fair skin is not well demonstrated. OBJECTIVES: This study investigated the proliferation and barrier function of dark keratinocytes (DK) and fair keratinocytes (FK), and the role of protease activated receptor (PAR)1 and PAR2. METHODS: DK and FK were isolated from human neonatal foreskins...
December 5, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27964879/activation-of-langerhans-cells-promotes-the-inflammation-in-imiquimod-induced-psoriasis-like-dermatitis
#18
Chunying Xiao, Zhenlai Zhu, Shuhong Sun, Jixin Gao, Meng Fu, Yufeng Liu, Gang Wang, Xu Yao, Wei Li
BACKGROUND: Langerhans cells (LCs) are epidermis-resident dendritic cells that sense and mediate stimuli from skin and outside world, and participate in various skin diseases, playing either pro-inflammatory or regulatory roles. However, the exact function of LCs in the pathogenesis of psoriasis remains unclear, and the conclusions of previous studies are controversial. OBJECTIVES: To explore the role of LCs in mouse model of imiquimod (IMQ)-induced psoriasis-like dermatitis using langerin-diphtheria toxin A (DTA) mice that are constitutively deficient in LCs...
December 5, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27964878/changes-in-t-cell-and-b-cell-composition-in-discoid-lupus-erythematosus-skin-at-different-stages
#19
LETTER
Jack C O'Brien, Gregory A Hosler, Benjamin F Chong
No abstract text is available yet for this article.
December 5, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27955882/melanoma-long-non-coding-rna-signature-predicts-prognostic-survival-and-directs-clinical-risk-specific-treatments
#20
Xijia Chen, Wenna Guo, Xin-Jian Xu, Fangchu Su, Yi Wang, Yingzheng Zhang, Qiang Wang, Liucun Zhu
BACKGROUND: Various studies have demonstrated that the Breslow thickness, tumor ulceration and mitotic index could serve as prognostic markers in patients with cutaneous melanoma. Recently, however, as these clinicopathological biomarkers lack efficient interpretation of endogenous mechanism of melanoma, the emphasis on the prognosis of melanoma has transformed to molecular tumor markers. OBJECTIVE: This study was designed to identify survival-related long non-coding RNAs (lncRNAs), and based on the different expressions of these lncRNAs, clinical risk-specific diagnosis and adjuvant therapy could be employed on melanoma patients, especially patients in the early course of disease or patients with a Breslow thickness no more than 2mm...
December 5, 2016: Journal of Dermatological Science
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