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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/28551093/cyclooxygenases-mediate-early-induction-of-interleukin-6-expression-by-solar-ultraviolet-irradiation-in-human-skin
#1
LETTER
Peiru Wang, Min Sun, John J Voorhees, Gary J Fisher, Yong Li
No abstract text is available yet for this article.
May 19, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28551094/a-synthetic-peptide-blocking-trpv1-activation-inhibits-uv-induced-skin-responses
#2
So Min Kang, Sangbum Han, Jang-Hee Oh, Young Mee Lee, Chi-Hyun Park, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
BACKGROUND: Transient receptor potential type 1 (TRPV1) can be activated by ultraviolet (UV) irradiation, and mediates UV-induced matrix metalloproteinase (MMP)-1 and proinflammatory cytokines in keratinocytes. Various chemicals and compounds targeting TRPV1 activation have been developed, but are not in clinical use mostly due to their safety issues. OBJECTIVE: We aimed to develop a novel TRPV1-targeting peptide to inhibit UV-induced responses in human skin. METHODS: We designed and generated a novel TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 (aa 701-709: Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr, QRAITILDT), Thr(705), and tested its efficacy of blocking UV-induced responses in HaCaT, mouse, and human skin...
May 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28545862/a-novel-pathogenic-variant-in-the-fzd6-gene-causes-recessive-nail-dysplasia-in-a-large-iranian-kindred
#3
Javad Mohammadi-Asl, Mohammad Reza Pourreza, Aliasgar Mohammadi, Ameneh Eskandari, Sima Mozafar-Jalali, Mohammad Amin Tabatabaiefar
BACKGROUND: Nail disorder nonsyndromic congenital (NDNC) is a very rare clinically and genetically heterogeneous disease inherited both in recessive or dominant modes. FZD6 is a component of Wnt-FZD signaling pathway in which recessive loss-of-function variants in the corresponding genes could lead to nail anomalies. OBJECTIVE: A large multiplex family with NDNC was referred for genetic counselling. Thorough genetic evaluation was performed. METHODS: PCR-Sanger sequencing was carried out for the coding exons and exon-intron boundaries of the FZD6 gene...
May 13, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28522139/in-vivo-confocal-raman-microscopic-determination-of-depth-profiles-of-the-stratum-corneum-lipid-organization-influenced-by-application-of-various-oils
#4
ChunSik Choe, Johannes Schleusener, Jürgen Lademann, Maxim E Darvin
BACKGROUND: The intercellular lipids (ICL) of stratum corneum (SC) play an important role in maintaining the skin barrier function. The lateral and lamellar packing order of ICL in SC is not homogenous, but rather depth-dependent. OBJECTIVE: This study aimed to analyze the influence of the topically applied mineral-derived (paraffin and petrolatum) and plant-derived (almond oil and jojoba oil) oils on the depth-dependent ICL profile ordering of the SC in vivo. METHOD: Confocal Raman microscopy (CRM), a unique tool to analyze the depth profile of the ICL structure non-invasively, is employed to investigate the interaction between oils and human SC in vivo...
May 6, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28551095/an-in-depth-analysis-identifies-two-new-independent-signals-in-11q23-3-associated-with-vitiligo-in-the-chinese-han-population
#5
Suli Zhao, Fang Fang, Xianfa Tang, Jinfa Dou, Wenjun Wang, Xiaodong Zheng, Liangdan Sun, Anping Zhang
BACKGROUND: Vitiligo is an autoimmune disease, characterized by progressive loss of skin pigmentation, which is caused by the interactions of multiple factors, such as heredity, immunity and environment. Recently, a single nucleotide polymorphism (SNP) rs638893 at 11q23.3 region was identified as a risk factor for vitiligo in genome-wide association studies and multiple SNPs in this region have been associated with other autoimmune diseases. OBJECTIVE: This study aims to identify additional susceptibility variants associated with vitiligo at 11q23...
May 3, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28532580/sirt1-ameliorates-systemic-sclerosis-by-targeting-the-mtor-pathway
#6
Xiaoxia Zhu, Haiyan Chu, Shuai Jiang, Qingmei Liu, Lei Liu, Yu Xue, Shucong Zheng, Weiguo Wan, Jianhua Qiu, Jiucun Wang, Hejian Zou
BACKGROUND: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation and fibrosis. Our previous research has indicated that Sirtuin1 (Sirt1) plays a role in the regulation of TNF-α-induced inflammation; however, whether Sirt1 may inhibit the progress of SSc by blocking inflammation remains unknown. OBJECTIVE: We aimed to investigate the function of Sirt1 in SSc. METHODS: The function and its mechanism of Sirt1 were evaluated in fibroblasts or scleroderma mice...
May 3, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28506683/the-caspase-1-inhibitor-card18-is-specifically-expressed-during-late-differentiation-of-keratinocytes-and-its-expression-is-lost-in-lichen-planus
#7
Haihong Qin, Jiang Jin, Heinz Fischer, Michael Mildner, Maria Gschwandtner, Veronika Mlitz, Leopold Eckhart, Erwin Tschachler
BACKGROUND: CARD18 contains a caspase recruitment domain (CARD) via which it binds to caspase-1 and thereby inhibits caspase-1-mediated activation of the pro-inflammatory cytokine interleukin (IL)-1β. OBJECTIVES: To determine the expression profile and the role of CARD18 during differentiation of keratinocytes and to compare the expression of CARD18 in normal skin and in inflammatory skin diseases. METHODS: Human keratinocytes were induced to differentiate in monolayer and in 3D skin equivalent cultures...
May 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28526214/high-glucose-environment-induced-intracellular-o-glcnac-glycosylation-and-reduced-galectin-7-expression-in-keratinocytes-implications-on-impaired-diabetic-wound-healing
#8
Shu-Mei Huang, Ching-Shuang Wu, Min-Hsi Chiu, Hui-Jun Yang, Gwo-Shing Chen, Cheng-Che E Lan
BACKGROUND: Diabetes is an important global health issue due to its increasing prevalence and association with various complications. Impaired wound healing is a serious complication associated with diabetes that frequently results in infection and amputation. Galectin-7 (Gal-7) has been reported to play an important role during skin wound healing. Previously, we had demonstrated that high glucose environment alters physiologic functions of keratinocytes and contributes to impaired wound healing in diabetic condition...
April 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28499588/clinical-and-molecular-characterization-of-a-13-year-old-indian-boy-with-cutis-laxa-type-2b-identification-of-two-novel-pycr1-mutations-by-amplicon-based-semiconductor-exome-sequencing
#9
LETTER
Marco Ritelli, Aparna Palit, Edoardo Giacopuzzi, Arun C Inamadar, Chiara Dordoni, Ajay Mujja, Meghana S Murgude, Marina Colombi
No abstract text is available yet for this article.
April 29, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28495119/toll-like-receptor-3-mediates-uvb-induced-mmp-13-and-mmp-3-expressions-in-mice
#10
LETTER
Cheng Yao, Sangbum Han, Yu-Dan Tian, Chang-Yup Shin, Chi-Hyun Park, Ye-Ji Kim, Dong Hun Lee, Jin Ho Chung
No abstract text is available yet for this article.
April 29, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28483277/ultraviolet-b-uvb-induces-development-of-early-melanocytic-progenitors-via-increased-oxidative-stress-in-vitro-suggesting-the-use-of-antioxidants-after-regimentation-in-uvb-phototherapy-for-vitiligo
#11
LETTER
Sebastian Yu, Hsin-Su Yu, Hsiao-Chi Lai, Ching-Shuang Wu, Hui-Ying Jheng, Cheng-Che Lan
No abstract text is available yet for this article.
April 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28465041/serum-levels-and-tissue-expression-of-interleukin-31-in-dermatitis-herpetiformis-and-bullous-pemphigoid
#12
LETTER
Diletta Bonciani, Lavinia Quintarelli, Elena Del Bianco, Beatrice Bianchi, Marzia Caproni
No abstract text is available yet for this article.
April 22, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28495120/combined-treatment-with-h1-and-h4-receptor-antagonists-reduces-inflammation-in-a-mouse-model-of-atopic-dermatitis
#13
Hanna Köchling, Katrin Schaper, Jenny Wilzopolski, Ralf Gutzmer, Thomas Werfel, Wolfgang Bäumer, Manfred Kietzmann, Kristine Rossbach
BACKGROUND: Histamine 4 receptor (H4R) antagonists are considered as new therapeutics for the treatment of atopic dermatitis (AD) and first clinical trials have already shown promising results. Histamine 1 receptor (H1R) antagonists are traditionally used to treat AD although the evidence for the efficacy is weak. The combined blockade of both, H1R and H4R, might provide synergistic anti-inflammatory. OBJECTIVE: The study was performed to test the anti-inflammatory potential of a combined treatment with an H1R and an H4R antagonist in a mouse AD model...
April 21, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28499587/the-phosphodiesterase-4-inhibitor-apremilast-inhibits-th1-but-promotes-th17-responses-induced-by-6-sulfo-lacnac-slan-dendritic-cells
#14
Stephanie Oehrl, Hridayesh Prakash, Annette Ebling, Nina Trenkler, Priscila Wölbing, Anja Kunze, Thomas Döbel, Marc Schmitz, Alexander Enk, Knut Schäkel
BACKGROUND: The phosphodiesterase 4 (PDE4) inhibitor apremilast increases cellular cAMP levels and has proven effective in the treatment of psoriasis and psoriasis arthritis. We recently described 6-sulfo LacNAc dendritic cells (slanDCs) as immature DCs in blood and as a subset of inflammatory dermal DCs in psoriasis with a pronounced capacity to produce proinflammatory cytokines and to program Th17/Th1 T cell responses. OBJECTIVE: The aim of this study was to investigate possible immune regulatory effects of the PDE4 inhibitor apremilast on slanDCs...
April 20, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28442193/a-retrospective-institutional-study-of-the-association-of-smoking-with-the-severity-of-hidradenitis-suppurativa
#15
LETTER
Clio Dessinioti, Chrisa Zisimou, Vassiliki Tzanetakou, George Ntritsos, George Kontochristopoulos, Christina Antoniou
No abstract text is available yet for this article.
April 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28450059/epidermal-iron-metabolism-for-iron-salvage
#16
Masayuki Asano, Kenshi Yamasaki, Takashi Yamauchi, Tadashi Terui, Setsuya Aiba
BACKGROUND: The epidermis shows a reverse iron gradient from the basal layer to the stratum corneum and consequently, little epidermal intracellular iron is lost by desquamation. OBJECTIVE: To clarify the underlying mechanism of iron salvage. METHODS: We first used immunohistochemistry and mRNA quantification to demonstrate the distinctive expression pattern of iron metabolism molecules. The obtained results were confirmed using normal human epidermal keratinocytes (NHEKs) during in vitro differentiation...
April 14, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28465042/high-constitutive-b7-h3-expression-on-human-keratinocytes-supports-t-cell-immunity
#17
LETTER
Dagmar Quandt, Eckhard Fiedler, Anja Müller, Wolfgang Ch Marsch, Barbara Seliger
No abstract text is available yet for this article.
April 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28427821/a-case-of-recessive-dystrophic-epidermolysis-bullosa-with-a-novel-c-6885_6898del14-mutation-in-the-col7a1-gene
#18
LETTER
Satoru Shinkuma, Tae Masunaga, Saori Miyawaki, Shota Takashima, Ken Natsuga, Toshifumi Nomura, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu
No abstract text is available yet for this article.
April 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28433429/immunological-function-of-langerhans-cells-in-hiv-infection
#19
Takamitsu Matsuzawa, Youichi Ogawa, Kohji Moriishi, Shinji Shimada, Tatsuyoshi Kawamura
BACKGROUND: Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the virus to CD4(+) T cells, leading to the dissemination of HIV. In contrast with the role of LCs in initial HIV acquisition, little is known about the modulation of immune responses by HIV-infected LCs. OBJECTIVE: We aimed to elucidate the induction of HIV-specific CD8(+) T cells and regulatory T cells (Tregs), both of which play important roles in regulating the progression of HIV infection...
April 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28433430/complementary-effect-of-hydroquinone-and-retinoic-acid-on-corneocyte-desquamation-with-their-combination-use
#20
Kyung Ah Cheong, Tae Ryong Lee, Ai-Young Lee
BACKGROUND: Retinoic acid (RA) enhances skin-lightening capabilities of hydroquinone (HQ), at least in part, by facilitating desquamation which leads to increase penetration of HQ. The desquamation also affects skin irritation levels. The mechanism of RA-induced desquamation, however, has not been completely explored and no such data has been available for HQ uses. OBJECTIVE: To examine the role of HQ, RA, and their combination in the desquamation. METHODS: Primary cultured normal human keratinocytes, which were treated with HQ and/or RA in presence or absence of serine-specific inhibitor Kazal type5 (SPINK5)/lympho-epithelial Kazal-type-related inhibitor (LEKTI) knockdown or recombinant human SPINK5/LEKTI, and biopsied skin samples applied with HQ or RA were examined...
April 7, 2017: Journal of Dermatological Science
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