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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/28711237/precise-role-of-dermal-fibroblasts-on-melanocyte-pigmentation
#1
REVIEW
Yinjuan Wang, Céline Viennet, Sophie Robin, Jean-Yves Berthon, Li He, Philippe Humbert
Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes. This review highlights the importance of fibroblast-derived melanogenic paracrine mediators in the regulation of melanocyte activities...
July 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28711238/ccl3-mip1%C3%AE-represents-a-biomarker-but-not-a-mandatory-cytokine-for-disease-development-in-experimental-epidermolysis-bullosa-acquisita
#2
LETTER
Michael Kasperkiewicz, Kathrin Kalies, Rene Pagel, Katja Bieber, Detlef Zillikens, Ralf J Ludwig
No abstract text is available yet for this article.
June 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28668559/characterization-of-a-novel-canine-t-cell-line-established-from-a-dog-with-cutaneous-t-cell-lymphoma
#3
LETTER
Kyohei Hara, Aki Iio, Ryota Asahina, Maiko Takahashi, Takashi Mori, Hidetaka Nishida, Hiroaki Kamishina, Hiroki Sakai, Katsuya Kitoh, Takuya Mizuno, Hajime Tsujimoto, Sadatoshi Maeda
No abstract text is available yet for this article.
June 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28687416/the-effect-of-interaction-of-heat-and-uvb-on-human-keratinocyte-novel-insights-on-uvb-induced-carcinogenesis-of-the-skin
#4
Cheng-Che E Lan, Yeng-Tseng Wang, Chi-Yu Lu, Ai-Hui Fang, Ching-Shuang Wu
BACKGROUND: Skin cancer is an important environmentally-related health issue. Although sun exposure is closely associated with increasing environmental heat, the effects of environmental heat on the skin, especially in the context of photocarcinogenesis, has not been carefully examined. OBJECTIVES: This study aimed to explore the effects and interactions of UVB radiation and environmental heat on photocarcinogenesis of the skin using cell and animal models. METHODS: Cultured keratinocytes and hairless mice were exposed to different treatment conditions including UVB radiation and environmental heat...
June 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655470/keratinocytes-in-atopic-dermatitis-express-abundant-%C3%AE-np73-regulating-thymic-stromal-lymphopoietin-production-via-nf-%C3%AE%C2%BAb
#5
Ayako Kumagai, Terufumi Kubo, Koji Kawata, Ryuta Kamekura, Keiji Yamashita, Sumito Jitsukawa, Tomonori Nagaya, Yasuyuki Sumikawa, Tetsuo Himi, Toshiharu Yamashita, Shingo Ichimiya
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that often cannot be completely controlled by modern medicine. Since multiple factors are intricately involved in the pathogenesis of AD, wide-ranging research is required for further advancement of AD treatment. Epidermal keratinocytes are the forefront to the external environment and play a pivotal role in the initiation of immune reaction against exogenous invasion. OBJECTIVE: Thymic stromal lymphopoietin (TSLP) is a keratinocyte-derived cytokine that induces differentiation and activation of type 2 helper T cells and innate lymphoid cells, cardinal effectors in pathophysiology of AD...
June 22, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28651848/the-first-case-of-multiple-pilomatricomas-caused-by-somatic-mutations-of-ctnnb1-without-any-associated-disorder
#6
LETTER
Eijiro Akasaka, Hajime Nakano, Tomohisa Fukui, Ayumi Korekawa, Takayuki Aizu, Daisuke Sawamura
No abstract text is available yet for this article.
June 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28666747/combined-immunotherapy-ctla-4-blockade-potentiates-anti-tumor-response-induced-by-transcutaneous-immunization
#7
Johanna Rausch, Pamela Aranda Lopez, Ariane Bialojan, Mark Denny, Peter Langguth, Hans Christian Probst, Hansjörg Schild, Markus P Radsak
BACKGROUND: The epidermal application of the Toll Like Receptor 7 agonist imiquimod and a T-cell peptide epitope (transcutaneous immunization, TCI) mediates systemic peptide-specific cytotoxic T-cell (CTL) responses and leads to tumor protection in a prophylactic tumor setting. However, it does not accomplish memory formation or permanent defiance of tumors in a therapeutic set-up. As a distinct immunologic approach, CTLA-4 blockade augments systemic immune responses and has shown long-lasting effects in preclinical experiments as well as in clinical trials...
June 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655469/transcutaneous-immunization-with-a-novel-imiquimod-nanoemulsion-induces-superior-t-cell-responses-and-virus-protection
#8
Pamela Aranda Lopez, Mark Denny, Ann-Kathrin Hartmann, Astrid Alflen, Hans Christian Probst, Esther von Stebut, Stefan Tenzer, Hansjörg Schild, Michael Stassen, Peter Langguth, Markus P Radsak
BACKGROUND: Transcutaneous immunization (TCI) is a novel vaccination strategy utilizing the skin associated lymphatic tissue to induce immune responses. TCI using a cytotoxic T lymphocyte (CTL) epitope and the Toll-like receptor 7 (TLR7) agonist imiquimod mounts strong CTL responses by activation and maturation of skin-derived dendritic cells (DCs) and their migration to lymph nodes. However, TCI based on the commercial formulation Aldara only induces transient CTL responses that needs further improvement for the induction of durable therapeutic immune responses...
June 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28673488/anthralin-modulates-the-expression-pattern-of-cytokeratins-and-antimicrobial-peptides-by-psoriatic-keratinocytes
#9
Julia Holstein, Birgit Fehrenbacher, Jürgen Brück, Eva Müller-Hermelink, Iris Schäfer, Melanie Carevic, Birgit Schittek, Martin Schaller, Kamran Ghoreschi, Franziska C Eberle
BACKGROUND: Psoriasis is an inflammatory skin disease with aberrant keratinocyte proliferation, presumably as a result of immune cell activation. Th17 cytokines like IL-17A and IL-22 are critically implicated in epidermal thickening, altered keratinocyte differentiation and production of innate factors such as antimicrobial peptides. Psoriasis treatment options include modern targeted therapies using anti-cytokine antibodies and traditional non-targeted treatments like anthralin (dithranol)...
June 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655471/early-inflammatory-players-in-cutanous-fibrosis
#10
REVIEW
Verena Raker, Jessica Haub, Ana Stojanovic, Adelheid Cerwenka, Detlef Schuppan, Kerstin Steinbrink
Systemic sclerosis (SSc) is one of the most complex systemic autoimmune diseases with multi-organ involvement and heterogeneous clinical manifestations. The exact etiology of SSc is still unknown. However, identified target structures are components of endothelial cells, the innate/adaptive immune systems and fibroblasts, resulting in the hallmarks of the disease in form of inflammation/autoimmunity, vasculopathy and fibrosis of the skin and internal organs. There has been a large body of evidence that the adaptive immune system with autoreactive T and B cells producing autoantibodies plays a central role in the pathogenesis of SSc but the role of earlier pathogenic processes involving the innate immune system, is far from being understood...
June 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28633806/il-17-for-therapy
#11
REVIEW
Florian C Kurschus, Sonja Moos
The cytokine IL-17 is now a target for an array of therapeutic monoclonal antibodies supposed to treat a variety of inflammatory diseases. The forerunner Secukinumab, an IL-17A neutralizing antibody, is meanwhile approved as first-line treatments for moderate-to-severe plaque psoriasis, and as second-line treatment for psoriatic arthritis and ankylosing spondylitis. Ixekizumab and Brodalumab, both also targeting the IL-17 pathway, were also recently approved by the FDA for plaque psoriasis. Using mice overexpressing IL-17A in a tissue of choice, we showed that the ectopic expression of this cytokine in keratinocytes resulted in a spontaneous and very strong form of psoriasis-like dermatitis...
June 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28633807/differential-induction-of-atf3-and-ho-1-in-myeloid-cells-and-keratinocytes-via-dimethylfumarate-or-cyclosporine-a
#12
Stefanie Müller, Nikola Smatlik, Marc Burian, Kamran Ghoreschi, Martin Röcken, Amir S Yazdi
BACKGROUND: Chronic inflammatory skin diseases are characterized by controlled proliferation of keratinocytes. Here, activating transcription factor 3 (ATF3) might play a fundamental role. In these inflammatory diseases, proliferation is controlled and only rarely leads to cancer development which can be supported by an inflammatory microenvironment. ATF3 is a dual function protein as it suppresses pro-inflammatory IL-6 and IL-8, but also acts as a pro-oncogenic factor by the suppression of p53...
June 12, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655473/keratinocytes-as-sensors-and-central-players-in-the-immune-defense-against-staphylococcus-aureus-in-the-skin
#13
REVIEW
Katharina Bitschar, Christiane Wolz, Bernhard Krismer, Andreas Peschel, Birgit Schittek
Healthy human skin provides an effective mechanical as well as immunologic barrier against pathogenic microorganisms with keratinocytes as the main cell type in the epidermis actively participating and orchestrating the innate immune response of the skin. As constituent of the outermost layer encountering potential pathogens they have to sense signals from the environment and must be able to initiate a differential immune response to harmless commensals and harmful pathogens. Staphylococci are among the most abundant colonizers of the skin: Whereas Staphylococcus epidermidis is part of the skin microbiota and ubiquitously colonizes human skin, Staphylococcus aureus is only rarely found on healthy human skin, but frequently colonizes the skin of atopic dermatitis (AD) patients...
June 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28629701/a-polymethoxyflavone-mixture-extracted-from-orange-peels-mainly-containing-nobiletin-3-3-4-5-6-7-8-heptamethoxyflavone-and-tangeretin-suppresses-melanogenesis-through-the-acidification-of-cell-organelles-including-melanosomes
#14
Norihiro Yoshizaki, Ron Hashizume, Hitoshi Masaki
BACKGROUND: Skin color is determined by melanin contents and its distribution. Melanin is synthesized in melanosomes of melanocytes, catalyzed by tyrosinase, melanogenic enzymes. Regarding the process of melanin synthesis, melanosomal pH is considered to play an important role, because it has been reported to differ between Caucasian and Black melanocytes. OBJECTIVE: Although polymethoxyflavone (PMF) has many beneficial effects, it has not been reported which PMF suppresses melanogenesis...
June 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655472/induction-of-skin-pathogenic-th22-cells-by-epicutaneous-allergen-exposure
#15
Ivana Glocova, Jürgen Brück, Julia Geisel, Eva Müller-Hermelink, Katja Widmaier, Amir S Yazdi, Martin Röcken, Kamran Ghoreschi
BACKGROUND: Atopic dermatitis (AD) is a common inflammatory skin disease with dysfunction of the skin barrier, an abnormal immune response and frequent allergies to environmental antigens like food antigens. Clinical observations suggest that certain diets can influence the course of AD. OBJECTIVE: Here we compared the phenotype of food allergen-specific T cells activated through skin or gut allergen exposure to transfer skin inflammation into naïve recipients upon epicutaenous allergen challenge...
June 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28623042/corneocyte-lipid-envelope-cle-the-key-structure-for-skin-barrier-function-and-ichthyosis-pathogenesis
#16
REVIEW
Masashi Akiyama
Research on the genetic abnormalities and pathogenetic processes of ichthyoses has progressed remarkably, and many causative genes and molecules have been identified in ichthyoses and ichthyosis syndromes. Most of the genes/molecules causative of ichthyosis are associated with the barrier function of the stratum corneum, and defects in the skin barrier play important roles in the pathogenesis of various ichthyosis phenotypes. It has been elucidated that, of the ichthyosis-causative genes, ABCA12, ALOXE3, ALOX12B, CYP4F22, CERS3, ABHD5, PNPLA1 and ELOVL4 work in the formation of the corneocyte lipid envelope (CLE), a structure that is essential to sound skin barrier function...
June 8, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28669590/tranexamic-acid-inhibits-melanogenesis-by-activating-the-autophagy-system-in-cultured-melanoma-cells
#17
Yeong Hee Cho, Jung Eun Park, Do Sung Lim, Jung Sup Lee
BACKGROUND: As interest in skin beauty increases, the development of new skin whitening agents has attracted substantial attention; however, the action mechanism of the agents developed so far remains largely unknown. Tranexamic acid (TXA) is commonly being used to reduce melanin synthesis in patients with melasma and also used as a raw material for functional whitening cosmetics, although its action mechanism is poorly understood. Autophagy has been well known to be essential for tissue homeostasis, adaptation to starvation, and removal of dysfunctional organelles or pathogens...
June 7, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28610715/specific-activation-of-inhibitory-interneurons-in-the-spinal-dorsal-horn-suppresses-repetitive-scratching-in-mouse-models-of-chronic-itch
#18
LETTER
Kensho Kanehisa, Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Kenji Takamori, Makoto Tsuda
No abstract text is available yet for this article.
June 3, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28602508/cyr61-ccn1-induces-ccl20-production-by-keratinocyte-via-activating-p38-and-jnk-ap-1-pathway-in-psoriasis
#19
Huidan Li, Haichuan Li, Rongfen Huo, Pinru Wu, Zhengyu Shen, Hui Xu, Baihua Shen, Ningli Li
BACKGROUND: Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1) has recently been implicated in psoriasis pathogenesis by promoting keratinocyte activation. However, the mechanisms by which CCN1 enhances cutaneous inflammation are not fully understood. OBJECTIVE: In this study, we investigated the role of CCN1 on the expression of CCL20 in human keratinocyte. METHODS AND RESULTS: By double-label immunofluorescence staining, we first identified that the expression of CCN1 colocalized well with CCL20 production in the epidermis of psoriasis skin lesion...
June 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28610717/increased-trem-1-expression-in-inflamed-skin-has-no-functional-impact-on-the-pathogenesis-of-cutaneous-disorders
#20
LETTER
Sören Dräger, Kathrin Kalies, Talles B Sidronio, Mareike Witte, Ralf J Ludwig, Katja Bieber
No abstract text is available yet for this article.
May 30, 2017: Journal of Dermatological Science
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