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Journal of Dermatological Science

Bunpei Katayama, Toshiyuki Ozawa, Kuniyuki Morimoto, Kunio Awazu, Nobuhisa Ito, Norihiro Honda, Naoki Oiso, Daisuke Tsuruta
BACKGROUND: Pseudomonas aeruginosa (PA) frequently develops antibiotic-resistant characteristics, which is clinically problematic. The main reason behind the rise of antibiotic-resistant PA is the extensive use of antibiotics. Therefore, a novel technique is needed to treat PA infections. Photodynamic therapy (PDT) is thought to have the potential to be a non-antibiotic treatment for infections. 5-Aminolevulinic acid (ALA), which works as a photosensitizer after being metabolized into protoporphyrin IX (PpIX) in the heme synthetic pathway, is used for PDT...
March 5, 2018: Journal of Dermatological Science
Woo-In Ryu, Hana Lee, Hyun Cheol Bae, Jiehyun Jeon, Hwa Jung Ryu, Jaehyung Kim, Ji Hyun Kim, Ji Won Son, JaeYoung Kim, Yasutomo Imai, Kiyofumi Yamanishi, Sang Hoon Jeong, Sang Wook Son
BACKGROUND: Tight junctions (TJs) have important roles in skin barrier function. The TJ protein claudin-1 (CLDN1) is decreased in atopic dermatitis (AD). However, little is known about the mechanism of CLDN1 down-expression. OBJECTIVE: To elucidate the effect of IL-33 on CLDN1 expression in keratinocytes. METHODS: Normal human epidermal keratinocytes (NHEKs) and human skin equivalent models (HSEMs) were cultured in vitro in the presence of IL-33...
March 2, 2018: Journal of Dermatological Science
Chao-Chun Yang, Tak-Wah Wong, Chih-Hung Lee, Chien-Hui Hong, Chung-Hsing Chang, Feng-Jie Lai, Shang-Hung Lin, Ching-Chi Chi, Tzu-Kai Lin, Hsi Yen, Chin-Han Wu, Hamm-Ming Sheu, Cheng-Che E Lan
BACKGROUND: Currently available topical treatments for actinic keratosis (AK) are associated with substantial side-effects. OBJECTIVES: To evaluate the efficacy and safety of topical SR-T100 gel in treating AK. METHODS: A multicenter, randomized, double-blinded phase III trial was conducted. Patients with at least two clinically visible AK were enrolled and a punch biopsy was performed on one of the AK to confirm the diagnosis. This study consisted of up to 16-week treatment and 8-week post-treatment periods...
March 2, 2018: Journal of Dermatological Science
Suh-Yeon Choi, Bum-Ho Bin, Wanil Kim, Eunkyung Lee, Tae Ryong Lee, Eun-Gyung Cho
BACKGROUND: Ultraviolet radiation (UVR) is a well-known factor in skin aging and pigmentation, and daily exposure to subcytotoxic doses of UVR might accelerate senescence and senescence-associated phenomena in human melanocytes. OBJECTIVE: To establish an in vitro melanocyte model to mimic the conditions of repeated exposure to subcytotoxic doses of UVB irradiation and to investigate key factor(s) for melanocyte senescence and senescence-associated phenomena. METHODS: Human epidermal melanocytes were exposed twice with 20 mJ/cm2 UVB over a 24-h interval and subsequently cultivated for 2 weeks...
March 2, 2018: Journal of Dermatological Science
Toru Kawai, Ryota Hayashi, Hiroyuki Nakai, Yutaka Shimomura, Mazen Kurban, Lamiaa Hamie, Hiroki Fujikawa, Atsushi Fujimoto, Riichiro Abe
No abstract text is available yet for this article.
February 21, 2018: Journal of Dermatological Science
Masahiro Kiso, Shigeharu Yabe, Munenari Itoh, Hidemi Nakagawa, Hitoshi Okochi
No abstract text is available yet for this article.
February 21, 2018: Journal of Dermatological Science
Mari Kiyomatsu-Oda, Hiroshi Uchi, Saori Morino-Koga, Masutaka Furue
BACKGROUND: Chronic eczema such as atopic dermatitis imposes significant socio-econo-psychologic burdens on the affected individuals. In addition to conventional topical treatments, phototherapy is recommended for patients with extensive lesions. Although immunosuppression is believed to explain its primary effectiveness, the underlying mechanisms of phototherapy remain unsolved. Ultraviolet irradiation generates various tryptophan photoproducts including 6-formylindolo[3,2-b]-carbazole (FICZ)...
February 21, 2018: Journal of Dermatological Science
Rafael Taeho Han, Hye Young Kim, Hyun Ryu, Wooyoung Jang, Seung Ha Cha, Hyo Young Kim, JaeHee Lee, Seung Keun Back, Hee Jin Kim, Heung Sik Na
BACKGROUND: Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease associated with hyperreactivity to environmental triggers. Among those, outdoor air pollutants such as particulate matter (PM) have been reported to aggravate pre-existing AD. However, underlying mechanisms of air pollution-induced aggravation of AD have hardly been studied. OBJECTIVE: To investigate the molecular mechanisms by which glyoxal, a PM-forming organic compound, exacerbates the symptoms of AD induced by neonatal capsaicin treatment...
February 21, 2018: Journal of Dermatological Science
Thomas M Rünger
No abstract text is available yet for this article.
February 21, 2018: Journal of Dermatological Science
Xinya Xu, Yue Zheng, Yunfen Huang, Jian Chen, Zijian Gong, Yuying Li, Chun Lu, Wei Lai, Qingfang Xu
BACKGROUND: The deposition of advanced glycation end products (AGEs) is accelerated in photoaged skin, but the underlying mechanisms remain elusive. Intracellular degradation has been recently considered to play an important role in AGEs removal. Although lysosomal cathepsin D (CatD), B (CatB), L(CatL) and proteasomes are found to degrade internalized AGEs, it remains unknown which protease degrades internalized AGEs in human dermal fibroblasts (HDFs), and whether a decrease in intracellular degradation contributes to enhanced AGEs deposition in photoaged skin...
February 19, 2018: Journal of Dermatological Science
Tianzhi Chen, Bingling Zhao, Yu Liu, Ruiwei Wang, Yujing Yang, Linpei Yang, Changsheng Dong
BACKGROUND: Although the impact of the microphthalamia-associated transcription factor (Mitf) signaling pathway on melanocytes progression has been extensively studied, the specific molecular mechanisms behind MITF-M-enhanced melanin production in melanocytes still need to be clarified. METHODS: In this study, we analyzed the levels of Mitf-M in skin tissues of different coat mice in order to further reveal the relationship between Mitf-M and skin pigmentation. To address the function of Mitf-M on melanogenesis, we have used an overexpression system and combined morphological and biochemical methods to investigate its localization in different coat color mice and pigmentation-related genes' expression in mouse melanocytes...
February 19, 2018: Journal of Dermatological Science
Fa-Ping Wang, Xiao-Ju Tang, Chuan-Qi Wei, Lin-Rui Xu, Hui Mao, Feng-Ming Luo
BACKGROUND: Dupilumab, a fully human monoclonal antibody against the interleukin-4-receptor α subunit, has been developed and used in clinical trials to treat atopic dermatitis (AD). OBJECTIVE: We aimed to assess the overall efficacy and safety of dupilumab treatment in AD. METHODS: PubMed, Embase, Cochrane library databases, and the Chinese Biological Medicine (CBM) published up to September 2017 were searched. All randomized controlled trials (RCTs) of dupilumab treatment on adult patients with AD were included...
February 19, 2018: Journal of Dermatological Science
Valerio De Vita, Eleonora Ruocco
No abstract text is available yet for this article.
February 15, 2018: Journal of Dermatological Science
Yoshiyuki Nakamura, Yasuhiro Fujisawa, Naoko Okiyama, Rei Watanabe, Ryota Tanaka, Yosuke Ishitsuka, Manabu Fujimoto, Hideaki Tahara
Our study suggested that surgical damage of the lymphatic system promotes tumor progression via impaired immune response. However, as pointed out by Valerio et al, lymph stasis is likely to induce immune stasis, resulting in not only enhanced tumor growth but also tumor generation. Although mechanisms of the tumor generation may not only include impaired immune response but also other factors induced by lymph stasis, we should avoid unnecessary lymphatic disruption in any surgeries and carefully consider the flap design to minimalize lymphatic disruption even in cases with benign tumors...
February 15, 2018: Journal of Dermatological Science
Agnieszka Gęgotek, Pedro Domingues, Elżbieta Skrzydlewska
BACKGROUND: Rutin, due to its polyphenolic structure, has antioxidant properties and can be used as a cytoprotective compound against UV-induced effects on skin cells. OBJECTIVE: The aim of this study was to examine the effect of rutin on proteomic profile in human skin fibroblasts irradiated with UV dose that induces apoptosis. METHODS: Proteome analysis based on the results obtained by the QExactive OrbiTrap mass spectrometer. RESULTS: Results show that rutin treatment more strongly protects against UVA-induced rather than UVB-induced increases in the total expression of proteins involved in antioxidant (such as SOD, TrxR, and Prxs 1/2) and inflammatory response (e...
February 15, 2018: Journal of Dermatological Science
Gaku Tsuji, Takamichi Ito, Takahito Chiba, Chikage Mitoma, Takeshi Nakahara, Hiroshi Uchi, Masutaka Furue
OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a C2 H2 zinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1-OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1-OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma...
February 12, 2018: Journal of Dermatological Science
Min Kyung Shin, Ki-Heon Jeong, Hyeongwon Choi, Hye-Jin Ahn, Mu-Hyoung Lee
BACKGROUND: Heat shock proteins (Hsps) are chaperone proteins, which are upregulated after various stresses. Hsp90 inhibitors have been investigated as adjuvant therapies for the treatment of melanoma. Thermal ablation could be a treatment option for surgically unresectable melanoma or congenital nevomelanocytic nevi, however, there is a limitation such as the possibility of recurrence. OBJECTIVE: We evaluated apoptosis in a melanoma cell line treated with the Hsp90 inhibitor 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), in hyperthermic conditions...
February 8, 2018: Journal of Dermatological Science
Risako Oi, Takuya Takeichi, Yusuke Okuno, Daiei Kojima, Kyoko Sugawara, Michihiro Kono, Hideki Muramatsu, Masashi Akiyama
No abstract text is available yet for this article.
February 6, 2018: Journal of Dermatological Science
Miwa Kanaoka, Yukie Yamaguchi, Noriko Komitsu, Carol A Feghali-Bostwick, Masahiro Ogawa, Kazuhiko Arima, Kenji Izuhara, Michiko Aihara
BACKGROUND: Periostin is a matricellular protein that belongs to a class of extracellular matrix (ECM)-related molecules defined by their ability to modulate cell-matrix interactions. We previously reported an elevated level of circulating periostin in patients with systemic sclerosis (SSc) and its association with the severity of skin sclerosis. OBJECTIVE: To examine the role of periostin in transforming growth factor (TGF)-β signaling involved in fibrosis. METHODS: Levels of periostin were examined in skin and lung fibroblasts obtained from SSc patients...
February 6, 2018: Journal of Dermatological Science
Sachiko Ono, Tetsuya Honda, Kenji Kabashima
No abstract text is available yet for this article.
February 6, 2018: Journal of Dermatological Science
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