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Journal of Dermatological Science

Mariko Yokota, Shoichi Yahagi, Hitoshi Masaki
BACKGROUND: Recently, environmental pollutants have become a concern not only for respiratory organs but also for skin-related human health, because skin is localized at the border between the human body and the external environment and is easily influenced by environmental pollutants. OBJECTIVE: Here, we investigated the effects of a novel pantothenic acid (PA) derivative, ethyl 2,4-dicarboethoxy pantothenate (EDCEP), on a diesel particulate extract (DPE) as a representative environmental pollutant that generates reactive oxygen species (ROS) through the activation of aryl hydrocarbon receptor (AHR) signaling...
September 9, 2018: Journal of Dermatological Science
Shih-Chun Yang, Tse-Hung Huang, Chun-Hui Chiu, Wei-Ling Chou, Ahmed Alalaiwe, Yuan-Chieh Yeh, Kuan-Wen Su, Jia-You Fang
BACKGROUND: Atopic dermatitis (AD) is an inflammatory skin disease with an associated barrier dysfunction and Staphylococcus aureus infection. The mainstay steroid and calcineurin inhibitor therapy shows some adverse effects. 2,4-Dimethoxy-6-methylbenzene-1,3-diol (DMD) is a benzenoid isolated from Antrodia camphorata. OBJECTIVE: We investigated the inhibitory effect of DMD on methicillin-resistant S. aureus (MRSA), the chemokine production in stimulated keratinocytes, and the AD-like lesion found in ovalbumin (OVA)-sensitized mice...
September 7, 2018: Journal of Dermatological Science
Hua-Ching Chang, Duen-Yi Huang, Nan-Lin Wu, Reiji Kannagi, Li-Fang Wang, Wan-Wan Lin
BACKGROUND: B lymphocyte-induced maturation protein-1 (BLIMP1) is a transcriptional repressor, and plays a crucial role in the regulation of development and functions of various immune cells. Currently, there is limited understanding about the regulation of BLIMP1 expression in keratinocytes and crosstalk between EGFR and BLIMP1 in skin homeostasis. OBJECTIVE: The aim of the study was to investigate the regulation and functional link between EGFR and BLIMP1 in human epidermal keratinocytes...
August 31, 2018: Journal of Dermatological Science
Masayuki Yamada, Masami Kagaya, Natsuko Noguchi, Shigeharu Ueki, Naoko Hasunuma, Shin-Ichi Osada, Motomu Manabe
BACKGROUND: Targeting cancer metabolism is a promising strategy in improving cancer treatment. OBJECTIVE: To introduce a targeted therapy with topical 3-bromopyruvate (3BP), aglycolytic inhibitor, into the clinic in the near future. METHOD: We investigated the anti-tumor efficacy of 3BP on melanoma cells in vitro and in a preclinical model. RESULTS: Our cell-based study demonstrated that 3BP showed cytotoxicity for melanoma cells under anchorage-dependent or independent cell growth via a reactive oxygen species-mediated and caspase-independent cell death pathway...
August 30, 2018: Journal of Dermatological Science
Weiwei Wu, Ruijun Zhang, Xiaowen Wang, Yinggai Song, Ruoyu Li
No abstract text is available yet for this article.
August 24, 2018: Journal of Dermatological Science
Carren Sy Hau, Teruo Shimizu, Yayoi Tada, Masahiro Kamata, Shintaro Takeoka, Sayaka Shibata, Aya Mitsui, Yoshihide Asano, Makoto Sugaya, Takafumi Kadono, Shinichi Sato, Shinichi Watanabe
BACKGROUND: Psoriasis is a Th1/Th17-mediated inflammatory dermatosis treated with topical corticosteroids and vitamin D3 analogs (VD3 As). OBJECTIVE: To compare the effects of a VD3 A maxacalcitol and betamethasone valerate (BV) steroid lotion on topical imiquimod (IMQ)-induced psoriasiform skin inflammation. METHODS: Female BALB/c mice were treated with vehicle, maxacalcitol or BV lotion on the skin for 3 days, and IMQ cream for 6 days...
August 24, 2018: Journal of Dermatological Science
Nahyun Choi, Junjeong Choi, Ji Hye Kim, Yaeji Jang, Joo Hye Yeo, Juwon Kang, Seung Yong Song, Jinu Lee, Jong-Hyuk Sung
BACKGROUND: Previous studies demonstrated that adipose-derived stem cells (ASCs) can promote hair growth, but unmet needs exist for enhancing ASC hair inductivity. OBJECTIVE: Therefore, we introduced three trichogenic factors platelet-derived growth factor-A, SOX2, and β-catenin to ASCs (tfASCs) and evaluated whether tfASCs have similar characteristics as dermal papilla (DP) cells. METHOD: Global gene expression was examined using NGS analysis...
August 16, 2018: Journal of Dermatological Science
Peng-Yang Hsu, Hsu-Heng Yen, Tao-Hsiang Yang, Che-Chun Su
BACKGROUND: Copper is an essential metal for maintenance of many biological functions; however, excessive amount can induce inflammation and oxidative stress. Tetrathiomolybdate (TM) is a copper chelator for treatment of Wilson's disease, and decreased the severity of autoimmune arthritis in mice. OBJECTIVE: In this report, we evaluated the effects of TM in a mouse model for psoriasis. METHODS: Imiquimod-induced psoriasis murine model was used...
August 11, 2018: Journal of Dermatological Science
Ren-Feng Liu, Chun-Bing Chen, Rosaline C Y Hui, Yue-Zon Kuan, Wen-Hung Chung
BACKGROUND: Erythema multiforme major (EMM) is an immune-mediated mucocutaneous eruption mostly triggered by herpes simplex virus (HSV) infection. A vicious circle of recurrence may be developed due to HSV reactivation and prolonged use of systemic corticosteroids to control EMM. Levamisole is an immunomodulator and has been applied to prevent relapses of recurrent HSV infection. OBJECTIVE: To evaluate the clinical efficacy and safety of levamisole in patients with recalcitrant recurrent EMM...
August 8, 2018: Journal of Dermatological Science
Stephen B Gauld, Donna Gauvin, Lauren Olson, Laura Leys, Stephanie Paulsboe, Zheng Liu, Rebecca M Edelmayer, Joseph Wetter, Katherine Salte, Yibing Wang, Susan Huang, Prisca Honore, Steven McGaraughty
BACKGROUND: Animal models of Psoriasis (PsO) are important for our understanding of the pathophysiology of human disease but rarely manifest all features of the disease. In order to facilitate greater understanding of the underlying biology of PsO it is key that we understand the strengths and limitations of models used. OBJECTIVE: While humanized mouse models are available for PsO they remain technically challenging, expensive, require prolonged timelines and require a continued source of human tissue...
August 7, 2018: Journal of Dermatological Science
Paola Savoia, Giulia Raina, Lara Camillo, Serena Farruggio, David Mary, Federica Veronese, Francesca Graziola, Elisa Zavattaro, Rossana Tiberio, Elena Grossini
BACKGROUND: Estrogens and phytoestrogens can hinder the aging process through mechanisms related to estrogen receptors (ERs), guanine nucleotide-binding protein-coupled receptor (GPER30), mitochondria function and nitric oxide (NO) release. Up to date, however, the above issues are a matter of debate. OBJECTIVE: To examine the effects elicited by 17 β-estradiol and genistein against peroxidation in human keratinocytes/fibroblasts and evaluate the role played by ERs, GPER30, mitochondria and NO...
August 6, 2018: Journal of Dermatological Science
Wei Zhang, Takashi Sakai, Haruna Matsuda-Hirose, Mizuki Goto, Tomoko Yamate, Yutaka Hatano
BACKGROUND: Th2 cytokines exhibit a variety of inhibitory effects on permeability barrier function via signal transducer and activator of transcription 6 (STAT6). However, the role of STAT6 signaling on the construction and/or homeostasis of permeability barrier function in the physiological state has not been fully assessed. OBJECTIVE: We compared permeability barrier function between Stat6-deficient and wild-type C57BL/6 mice at steady state. METHODS AND RESULTS: Measurement of transepidermal water loss and quantitative penetration assay revealed that permeability barrier function was superior in Stat6-deficient mice...
August 6, 2018: Journal of Dermatological Science
Kentaro Kajiya, Ryoma Bise, Catharina Commerford, Imari Sato, Toyonobu Yamashita, Michael Detmar
No abstract text is available yet for this article.
July 24, 2018: Journal of Dermatological Science
Juana Schwartz, Esther Moreno, Alba Calvo, Laura Blanco, Celia Fernández-Rubio, Carmen Sanmartín, Paul Nguewa, Juan M Irache, Esther Larrea, Socorro Espuelas
BACKGROUND: Cutaneous leishmaniasis (CL) skin lesions are the result of a deregulated immune response, which is unable to eliminate Leishmania parasites. The control of both, parasites and host immune response, is critical to prevent tissue destruction. The skin ulceration has been correlated with high TNF-α level. OBJECTIVE: Because human anti-TNF-α antibodies (Ab) have been successfully assayed in several mice inflammatory diseases, we hypothesized that their anti-inflammatory effect could optimize the healing of CL lesions achieved after topical application of paromomycin (PM), the current chemotherapy against CL...
July 17, 2018: Journal of Dermatological Science
Nozomu Toyama, Kimiyasu Shiraki
BACKGROUND: Effects of universal varicella vaccination on the herpes zoster (HZ) incidence have not been elucidated. Universal varicella vaccination was introduced in Japan in October 2014. OBJECTIVE: We investigated the effects of universal varicella vaccination on HZ epidemiology. METHODS: Patients with HZ have been monitored by the Miyazaki Dermatologist Society since 1997, and the effects of universal vaccination on the HZ incidences have been analyzed to determine which generation is most affected...
July 10, 2018: Journal of Dermatological Science
Núria Dalmau, Nathalie Andrieu-Abadie, Romà Tauler, Carmen Bedia
BACKGROUND: Ultraviolet (UV) radiation is known to be one of the most important environmental hazards acting on the skin. The most part of UV radiation is absorbed in the epidermis, where keratinocytes are the most abundant and exposed cell type. Lipids have an important role in skin biology, not only for their important contribution to the maintenance of the permeability barrier but also for the production and storage of energy, membrane organization and cell signalling functions. However, the effects on the lipid composition of keratinocytes under UV radiation are little explored...
July 10, 2018: Journal of Dermatological Science
Kexiang Yan, Ling Han, Hui Deng, Xu Fang, Zhenghua Zhang, Guiqin Huang, Zhi Zhong Zheng, Qiong Huang, Jinhua Xu
BACKGROUND: Few studies have explored the differences of immunopathogenesis in plaque vs guttate psoriasis, especially on the inhibitory role of regulatory T cells (Tregs) on IL-17/ IFN-γ production and the impact of CD4+T cells on keratinocytes. OBJECTIVE: To investigate the percentage and inhibitory function of CD4+CD25high Treg and differential expressions of IL-17/ IFN-γ in plaque vs guttate psoriasis, and the effects of CD4 + T cells on the proliferation of keratinocytes...
July 7, 2018: Journal of Dermatological Science
Hao Song, Yue Tao, Nana Ni, Xiaowei Zhou, Jingshu Xiong, Xuesi Zeng, Xiulian Xu, Jinliang Qi, Jianfang Sun
BACKGROUND: The CC chemokine ligand 18 (CCL18) has a higher expression in some tumors, while the CCL18 level can be a marker of tumor progression and prognosis. We previously reported that the expression of CCL18 gene was dramatically up-regulated in cutaneous malignant melanoma (CMM) and its expression levels were correlated with tumor thickness. OBJECTIVE: To investigate miRNAs which could target the CCL18 gene so as to mediate CMM development and improvement...
July 3, 2018: Journal of Dermatological Science
Yuzo Yoshida, Kentaro Kajiya, Jiro Kishimoto, Michael Detmar
No abstract text is available yet for this article.
June 30, 2018: Journal of Dermatological Science
Yu Gabe, Akimitsu Miyaji, Masahiro Kohno, Akira Hachiya, Shigeru Moriwaki, Toshihide Baba
BACKGROUND: Rhododendrol (4-(4-hydroxyphenyl)-2-butanol) has been used as a lightening/whitening cosmetic but was recently reported to induce leukoderma. Although rhododendrol has been shown to be transformed by tyrosinase to hydroxyl-rhododendrol, which is cytotoxic to melanocytes, its detailed mechanism of action including the involvement of reactive oxygen species is not clearly understood. OBJECTIVE: To confirm the relationship of hydroxyl radical generation to melanocyte cytotoxicity induced by rhododendrol, this study was performed...
June 27, 2018: Journal of Dermatological Science
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