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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/28797686/clinical-application-of-next-generation-sequencing-for-the-diagnosis-of-segmental-neurofibromatosis
#1
LETTER
Younhee Ko, Chelho Lee, Hyunjoo Lee, Minjung Lee, Jin-Sung Lee
No abstract text is available yet for this article.
July 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28793966/delivery-of-antioxidant-enzymes-for-prevention-of-ultraviolet-irradiation-induced-epidermal-damage
#2
LETTER
Brianna Hammiller, Bala Vamsi K Karuturi, Christina Miller, Matti Holmes, Vinod Labhasetwar, Gary Madsen, Laura A Hansen
No abstract text is available yet for this article.
July 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28764861/silencing-of-metallothionein-1a-gene-in-melanoma
#3
Yoshimasa Nobeyama, Hidemi Nakagawa
BACKGROUND: When a CpG island (CGI; a dense cluster of CpGs) located in the 5' region of a gene is methylated, its transcription is suppressed. Tumorigenesis of melanoma is associated with trace elements. Metallothionein 1A is closely associated with the metabolism of trace elements. However, little is known about the metallothionein 1A gene (MT1A) in melanoma. OBJECTIVE: The purpose is to reveal the methylation and expression status of MT1A in melanoma. METHODS: Quantitative real-time methylation-specific PCR (RT-MSP) and bisulfite sequencing were performed to examine MT1A methylation status...
July 21, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28747266/igg4-complement-and-the-mechanisms-of-blister-formation-in-pemphigus-and-bullous-pemphigoid
#4
REVIEW
Teruki Dainichi, Zachary Chow, Kenji Kabashima
Autoimmune bullous diseases are at the forefront of the research field on autoimmune diseases. Pemphigus and pemphigoid were historical entities in the world of descriptive dermatology for a long time. Recently, however, dermatologists and skin biologists have elegantly explained the novel pathomechanism of pemphigus and pemphigoid diseases. IgG4 is the major subclass of autoantibodies in autoimmune bullous diseases and is known to have little activity to activate complement. It is quite acceptable for pemphigus, because acantholysis in pemphigus has been demonstrated to be complement-independent...
July 18, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28754405/comprehensive-cancer-related-gene-analysis-reveals-that-active-kras-mutation-is-a-prognostic-mutation-in-mycosis-fungoides
#5
LETTER
Teruki Yanagi, Hiroshi Nishihara, Kyoko Fujii, Machiko Nishimura, Atsushi Narahira, Kanae Takahashi, Hiroaki Iwata, Hiroo Hata, Shinya Kitamura, Keisuke Imafuku, Hiroshi Shimizu
No abstract text is available yet for this article.
July 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28736218/fluctuations-in-routine-blood-count-might-signal-severe-immune-related-adverse-events-in-melanoma-patients-treated-with-nivolumab
#6
Yasuhiro Fujisawa, Koji Yoshino, Atsushi Otsuka, Takeru Funakoshi, Taku Fujimura, Yuki Yamamoto, Hiroo Hata, Masahiko Gosho, Ryota Tanaka, Kei Yamaguchi, Yumi Nonomura, Ikuko Hirai, Sadanori Furudate, Hisako Okuhira, Keisuke Imafuku, Megumi Aoki, Shigeto Matsushita
BACKGROUND: Although nivolumab significantly prolongs survival of metastatic melanoma, about 10% of patients experience severe, even fatal immune-related adverse events (irAEs). Biomarkers to predict irAEs are, therefore, of great interest. OBJECTIVE: We aimed to correlate changes in routine blood count parameters to the occurrence of serious irAEs (grade 3/4 [G3/4] or lung/gastrointestinal [lung/GI] irAEs) in patients with melanoma who were treated with nivolumab...
July 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28743611/increased-frequencies-of-basophils-type-2-innate-lymphoid-cells-and-th2-cells-in-skin-of-patients-with-atopic-dermatitis-but-not-psoriasis
#7
Shunya Mashiko, Heena Mehta, Robert Bissonnette, Marika Sarfati
BACKGROUND: Pathogenesis of atopic dermatitis (AD) involves interaction between type 2 cells that include basophils, mast cells, innate lymphoid type 2 cells (ILC2), and Th2 cells. Levels of IL-4 and IL-13 are elevated in AD patients. OBJECTIVE: Here, we investigated the distribution of type 2 cells and the source of IL-4 and IL-13 in skin and blood of AD relative to psoriasis. METHODS: Lesional skin biopsies and blood were collected from patients...
July 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28743610/epidemiology-and-comorbidities-of-patients-with-chronic-urticaria-in-taiwan%C3%A2-a-nationwide-population-based-study
#8
Chia-Yu Chu, Yung-Tsu Cho, Jhih-Hua Jiang, Eve I-Chun Lin, Chao-Hsiun Tang
BACKGROUND: Comprehensive data regarding the epidemiology of chronic urticaria (CU) in general populations are scant. OBJECTIVES: To investigate the prevalence, incidence, and comorbidities of CU in general population. METHODS: The data were sourced from the National Health Insurance Research Database (NHIRD) for 2009-2012. Patients who had a primary/secondary ICD-9-CM diagnosis code of 708.1, 708.8, or 708.9 during the year with at least two outpatient visits and an antihistamine prescription, were identified as the cases of CU for each year...
July 15, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28736219/detection-of-mucous-membrane-pemphigoid-autoantibodies-by-full-length-bp180-enzyme-linked-immunosorbent-assay
#9
LETTER
Kentaro Izumi, Wataru Nishie, Yosuke Mai, Hideyuki Ujiie, Hiroaki Iwata, Ken Natsuga, Hiroshi Shimizu
No abstract text is available yet for this article.
July 13, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28743609/expression-of-cd73-slows-down-migration-of-skin-dendritic-cells-affecting-the-sensitization-phase-of-contact-hypersensitivity-reactions-in-mice
#10
A Neuberger, S Ring, C Silva-Vilches, J Schrader, A Enk, K Mahnke
BACKGROUND: Application of haptens to the skin induces release of immune stimulatory ATP into the extracellular space. This "danger" signal can be converted to immunosuppressive adenosine (ADO) by the action of the ectonucleotidases CD39 and CD73, expressed by skin and immune cells. Thus, the expression and regulation of CD73 by skin derived cells may have crucial influence on the outcome of contact hypersensitivity (CHS) reactions. OBJECTIVE: To investigate the role of CD73 expression during 2,4,6-trinitrochlorobenzene (TNCB) induced CHS reactions...
July 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28711237/precise-role-of-dermal-fibroblasts-on-melanocyte-pigmentation
#11
REVIEW
Yinjuan Wang, Céline Viennet, Sophie Robin, Jean-Yves Berthon, Li He, Philippe Humbert
Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes. This review highlights the importance of fibroblast-derived melanogenic paracrine mediators in the regulation of melanocyte activities...
July 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28711238/ccl3-mip1%C3%AE-represents-a-biomarker-but-not-a-mandatory-cytokine-for-disease-development-in-experimental-epidermolysis-bullosa-acquisita
#12
LETTER
Michael Kasperkiewicz, Kathrin Kalies, Rene Pagel, Katja Bieber, Detlef Zillikens, Ralf J Ludwig
No abstract text is available yet for this article.
June 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28668559/characterization-of-a-novel-canine-t-cell-line-established-from-a-dog-with-cutaneous-t-cell-lymphoma
#13
LETTER
Kyohei Hara, Aki Iio, Ryota Asahina, Maiko Takahashi, Takashi Mori, Hidetaka Nishida, Hiroaki Kamishina, Hiroki Sakai, Katsuya Kitoh, Takuya Mizuno, Hajime Tsujimoto, Sadatoshi Maeda
No abstract text is available yet for this article.
June 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28687416/the-effect-of-interaction-of-heat-and-uvb-on-human-keratinocyte-novel-insights-on-uvb-induced-carcinogenesis-of-the-skin
#14
Cheng-Che E Lan, Yeng-Tseng Wang, Chi-Yu Lu, Ai-Hui Fang, Ching-Shuang Wu
BACKGROUND: Skin cancer is an important environmentally-related health issue. Although sun exposure is closely associated with increasing environmental heat, the effects of environmental heat on the skin, especially in the context of photocarcinogenesis, has not been carefully examined. OBJECTIVES: This study aimed to explore the effects and interactions of UVB radiation and environmental heat on photocarcinogenesis of the skin using cell and animal models. METHODS: Cultured keratinocytes and hairless mice were exposed to different treatment conditions including UVB radiation and environmental heat...
June 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28732748/controlling-the-pro-inflammatory-function-of-6-sulfo-lacnac-slan-dendritic-cells-with-dimethylfumarate
#15
Stephanie Oehrl, Florina Olaru, Anja Kunze, Michael Maas, Silvia Pezer, Marc Schmitz, Knut Schäkel
BACKROUND: The fumaric acid ester (FAE) dimethylfumarate (DMF) is a small molecule immunomodulator successfully used for the treatment of psoriasis and multiple sclerosis (MS). DMF is thought to inhibit pathogenic immune responses with Th17/Th1T cells, and IL-23/IL-12 producing dendritic cells (DCs). 6-sulfo LacNAc expressing dendritic cells (slanDCs) are a human pro-inflammatory cell type found frequently among the infiltrating leukocytes in skin lesions of psoriasis and brain lesions of MS...
June 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655470/keratinocytes-in-atopic-dermatitis-express-abundant-%C3%AE-np73-regulating-thymic-stromal-lymphopoietin-production-via-nf-%C3%AE%C2%BAb
#16
Ayako Kumagai, Terufumi Kubo, Koji Kawata, Ryuta Kamekura, Keiji Yamashita, Sumito Jitsukawa, Tomonori Nagaya, Yasuyuki Sumikawa, Tetsuo Himi, Toshiharu Yamashita, Shingo Ichimiya
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease that often cannot be completely controlled by modern medicine. Since multiple factors are intricately involved in the pathogenesis of AD, wide-ranging research is required for further advancement of AD treatment. Epidermal keratinocytes are the forefront to the external environment and play a pivotal role in the initiation of immune reaction against exogenous invasion. OBJECTIVE: Thymic stromal lymphopoietin (TSLP) is a keratinocyte-derived cytokine that induces differentiation and activation of type 2 helper T cells and innate lymphoid cells, cardinal effectors in pathophysiology of AD...
June 22, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28651848/the-first-case-of-multiple-pilomatricomas-caused-by-somatic-mutations-of-ctnnb1-without-any-associated-disorder
#17
LETTER
Eijiro Akasaka, Hajime Nakano, Tomohisa Fukui, Ayumi Korekawa, Takayuki Aizu, Daisuke Sawamura
No abstract text is available yet for this article.
June 17, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28666747/combined-immunotherapy-ctla-4-blockade-potentiates-anti-tumor-response-induced-by-transcutaneous-immunization
#18
Johanna Rausch, Pamela Aranda Lopez, Ariane Bialojan, Mark Denny, Peter Langguth, Hans Christian Probst, Hansjörg Schild, Markus P Radsak
BACKGROUND: The epidermal application of the Toll Like Receptor 7 agonist imiquimod and a T-cell peptide epitope (transcutaneous immunization, TCI) mediates systemic peptide-specific cytotoxic T-cell (CTL) responses and leads to tumor protection in a prophylactic tumor setting. However, it does not accomplish memory formation or permanent defiance of tumors in a therapeutic set-up. As a distinct immunologic approach, CTLA-4 blockade augments systemic immune responses and has shown long-lasting effects in preclinical experiments as well as in clinical trials...
June 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28655469/transcutaneous-immunization-with-a-novel-imiquimod-nanoemulsion-induces-superior-t-cell-responses-and-virus-protection
#19
Pamela Aranda Lopez, Mark Denny, Ann-Kathrin Hartmann, Astrid Alflen, Hans Christian Probst, Esther von Stebut, Stefan Tenzer, Hansjörg Schild, Michael Stassen, Peter Langguth, Markus P Radsak
BACKGROUND: Transcutaneous immunization (TCI) is a novel vaccination strategy utilizing the skin associated lymphatic tissue to induce immune responses. TCI using a cytotoxic T lymphocyte (CTL) epitope and the Toll-like receptor 7 (TLR7) agonist imiquimod mounts strong CTL responses by activation and maturation of skin-derived dendritic cells (DCs) and their migration to lymph nodes. However, TCI based on the commercial formulation Aldara only induces transient CTL responses that needs further improvement for the induction of durable therapeutic immune responses...
June 16, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28673488/anthralin-modulates-the-expression-pattern-of-cytokeratins-and-antimicrobial-peptides-by-psoriatic-keratinocytes
#20
Julia Holstein, Birgit Fehrenbacher, Jürgen Brück, Eva Müller-Hermelink, Iris Schäfer, Melanie Carevic, Birgit Schittek, Martin Schaller, Kamran Ghoreschi, Franziska C Eberle
BACKGROUND: Psoriasis is an inflammatory skin disease with aberrant keratinocyte proliferation, presumably as a result of immune cell activation. Th17 cytokines like IL-17A and IL-22 are critically implicated in epidermal thickening, altered keratinocyte differentiation and production of innate factors such as antimicrobial peptides. Psoriasis treatment options include modern targeted therapies using anti-cytokine antibodies and traditional non-targeted treatments like anthralin (dithranol)...
June 15, 2017: Journal of Dermatological Science
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