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Journal of Dermatological Science

Yimeng Wang, Xiaoguang Gu, Weiwei Li, Qian Zhang, Chunlei Zhang
BACKGROUND: Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 is up-regulated in several types of human cancers. However, little is known about the role of PAK1 in the pathogenesis of CTCL. OBJECTIVE: The aim of this study was to evaluate the expression pattern and underlying mechanism of PAK1 in CTCL...
January 4, 2018: Journal of Dermatological Science
Soichiro Sawamura, Masatoshi Jinnin, Kuniko Inoue, Keitaro Yamane, Noritoshi Honda, Ikko Kajihara, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
BACKGROUND: Various cytokines have been indicated to be involved in the pathogenesis of systemic sclerosis (SSc). IL-22 is one of the member of IL-10 cytokine family, and several studies have implicated IL-22 signaling in the pathogenesis of autoimmune diseases. OBJECTIVES: To clarify the role of IL-22 in the regulatory mechanism of ECM expression and to determine the contribution of IL-22 to the phenotype of SSc. METHODS: The effect of IL-22 on ECM expression in normal fibroblasts was determined by using PCR array, real-time PCR and immunoblotting...
December 29, 2017: Journal of Dermatological Science
Prakash Shakya, Khem N Pokhrel, Linda B Mlunde, Suyun Tan, Erika Ota, Hironori Niizeki
INTRODUCTION: Primary hypertrophic osteoarthropathy (PHO), also known as pachydermoperiostosis is a rare genetic disease which predominantly affects skin, bone and soft connective tissue. It is characterized by the triad of pachydermia, digital clubbing and periostosis of long bones. Arthralgia or arthritis is also present in most of the cases. Genetic studies have identified the impaired PGE2 metabolism as a culprit for hypertrophic osteoarthropathy in PHO cases. We conducted a systematic review to examine the effectiveness of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), a PGE2 synthesis blocker to reduce the symptoms among PHO patients...
December 28, 2017: Journal of Dermatological Science
Makiko Kawaguchi, Tomonori Oka, Makoto Sugaya, Hiraku Suga, Takayuki Kimura, Sohshi Morimura, Hideki Fujita, Shinichi Sato
BACKGROUNDS: IFN regulatory factor (IRF)-2 is one of the potential susceptibility genes for psoriasis, but how this gene influences psoriasis pathogenesis is unclear. Topical application of imiquimod (IMQ), a TLR7 ligand, induces psoriasis-like skin lesions in mice. OBJECTIVE: The aim of this study was to investigate whether IRF-2 gene status would influence severity of skin disease in IMQ-treated mice. METHODS: Imiquimod-induced psoriasis-like skin inflammation was assessed by clinical findings, histology, and cytokine expression...
December 28, 2017: Journal of Dermatological Science
Helena D Zomer, Andrea G Trentin
Despite the great progress in translational research concerning skin wound healing in the last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most commonly used model, as it is easy to maintain and standardize, and is economically accessible. However, differences between murine and human skin repair, such as the contraction promoted by panniculus carnosus and the role of specific niches of skin stem cells, make it difficult to bridge the gap between preclinical and clinical studies...
December 26, 2017: Journal of Dermatological Science
Masao Fujiwara, Takahiro Suzuki, Akira Kasuya, Takatoshi Shimauchi, Hidekazu Fukamizu, Yoshiki Tokura
BACKGROUND: The status of sentinel lymph node (SLN) is one of the most predictive prognostic factors in patients with clinically localized malignant melanomas (MMs). However, since the positive SLN metastatic rate is as low as 20%, it is desirable to minimize SLN biopsy performance with imaging. By dynamic lymphoscintigraphy, we have proposed the lymphatic transit rate (LTR), the value that the distance between the primary lesion and SLN is divided by scintigraphic saturation time. LTR represents the scintigraphic saturation velocity and can be used for evaluation of metastasis of skin cancers...
December 24, 2017: Journal of Dermatological Science
Thaise Gonçalves Araújo, Guilherme Pereira Oliveira, Fabrícia de Matos Oliveira, Adriana Freitas Neves, Sara Teixeira Soares Mota, Isabela Maria Bernardes Goulart, Luiz Ricardo Goulart
No abstract text is available yet for this article.
December 23, 2017: Journal of Dermatological Science
Jeeyong Lee, Jiwon Ko, Jae Youn Yi
BACKGROUND: Histone deacetylase (HDAC) is an enzyme that regulates gene expression, cell cycle arrest, apoptosis and modulation of various pathways. HDAC inhibitors (HDACis) can modulate these pathways by hyper-acetylating target proteins, thereby acting as cancer chemotherapeutic agents. OBJECTIVE: One of HDACis, suberoylanilide hydroxamic acid (SAHA), has been found to regulate the Smad signaling pathway, by an as yet unclear mechanism. This study therefore investigated the mechanism by which SAHA regulates Smad signaling in the melanoma cell line SK-Mel-5...
December 21, 2017: Journal of Dermatological Science
Miho Mukai, Harumi Fujita, Noriko Umegaki-Arao, Takashi Sasaki, Fumiyo Yasuda-Sekiguchi, Tsuyoshi Isojima, Sachiko Kitanaka, Masayuki Amagai, Akiharu Kubo
Nail patella syndrome is a autosomal dominant disorder caused by a genetic alteration in LMX1B. We identified a novel heterozygous in-frame indel mutation of LMX1B in a family of Nail patella syndrome. Impaired transcriptional activity but not dominant negative effect of mutant LMX1B were revealed using a transcriptional reporter assay, indicating that the mutation caused nail patella syndrome in this family via haploinsufficiency of the transcriptional activity of LMX1B.
December 19, 2017: Journal of Dermatological Science
M Julià, M Consuegra-Fernández, A Guilabert, C Muñoz, A Esteve, N Armiger-Borràs, F Santiago, M T Arias, R Romaní, C Ferrándiz, J M Carrascosa, E Pedrosa, M Alsina-Gibert, F Lozano, J M Mascaró-Galy
No abstract text is available yet for this article.
December 19, 2017: Journal of Dermatological Science
Kanad Ghosh, Kyle O'Neil, Brian C Capell
By regulating the accessibility of the genome, epigenetic regulators such as histone proteins and the chromatin-modifying enzymes that act upon them control gene expression. Proper regulation of this "histone code" allows for the precise control of transcriptional networks that are essential for establishing and maintaining cell fate and identity, disruption of which may drive carcinogenesis. How these dynamic epigenetic regulators contribute to both skin homeostasis and disease is only beginning to be understood...
December 18, 2017: Journal of Dermatological Science
Ryosuke Segawa, Kenichi Shigeeda, Takahiro Hatayama, Jiangxu Dong, Natsumi Mizuno, Takahiro Moriya, Masahiro Hiratsuka, Noriyasu Hirasawa
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, such as atopic dermatitis and psoriasis. Tumor necrosis factor (TNF)-α, a key cytokine in inflammatory skin diseases, is a known TSLP inducer. TNF-α activates NF-κB and induces transactivation of epidermal growth factor receptor (EGFR) in epithelial cells. However, the detailed mechanism of TSLP induction by TNF-α has remained unclear. OBJECTIVE: We investigated the involvement of TNF-α-induced EGFR transactivation in TSLP expression...
December 18, 2017: Journal of Dermatological Science
Ryosuke Saigusa, Yoshihide Asano, Takashi Yamashita, Takehiro Takahashi, Kouki Nakamura, Shunsuke Miura, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Hayakazu Sumida, Zenshiro Tamaki, Miki Miyazaki, Ayumi Yoshizaki, Shinichi Sato
BACKGROUND: Scleroderma is a chronic disease of unknown etiology characterized by skin fibrosis and is divided into two clinical entities: systemic sclerosis (SSc) and localized scleroderma (LSc). In general, LSc is rarely complicated with SSc, but a certain portion of SSc patients manifests bilateral symmetric LSc-like lesions on the trunk and extremities. OBJECTIVE: We investigated SSc patients with LSc-like lesions to clarify the underlying pathophysiology. METHODS: Nine SSc cases complicated with LSc-like lesions were clinically and histologically characterized...
December 16, 2017: Journal of Dermatological Science
Paulina Langa, Anna Wardowska, Jacek Zieliński, Justyna Podolak-Popinigis, Piotr Sass, Paweł Sosnowski, Karolina Kondej, Alicja Renkielska, Paweł Sachadyn, Piotr Trzonkowski, Michał Pikuła
BACKGROUND: Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability and significant biological activity. OBJECTIVES: The goal of this study was to characterize the in vitro cultured progenitor cells and to assess whether the cells with the progenitor phenotype are able to enhance wound healing...
December 13, 2017: Journal of Dermatological Science
Luting Yang, Weinan Guo, Shaolong Zhang, Gang Wang
Ubiquitination is an important post-translational modification that regulates a myriad of biological processes such as inflammation, immune response, cell differentiation and proliferation. During the last decade, progress in proteomics contributed to the identification of new E3 ligases and their substrates. Hence, deregulated ubiquitination events are found to be involved in several inflammatory disorders, exemplifying by systemic lupus erythematosus (SLE), type 1 diabetes, rheumatoid arthritis (RA) and psoriasis...
December 13, 2017: Journal of Dermatological Science
Hitoshi Masaki, Taeko Mizutani, Naomi Ogawa, Hiroshi Suzuki, Yuri Okano, Hirotaka Akita
No abstract text is available yet for this article.
December 4, 2017: Journal of Dermatological Science
Hui Fang, Shengxian Shen, Xiaodong Zheng, Erle Dang, Jieyu Zhang, Shuai Shao, Pei Qiao, Qiuju Li, Hua Wang, Caixia Li, Liangdan Sun, Gang Wang
BACKGROUND: Bullous pemphigoid (BP) is one of the most common autoimmune skin diseases. Associations of genes, especially human leukocyte antigen (HLA)-DQ alleles, with BP indicate that genetic predisposition contributes to the disease. OBJECTIVES: To evaluate the association of HLA class I and HLA class II alleles with susceptibility to BP in the northern Chinese Han population. METHODS: We performed genotype for HLA-A, -B, -C, -G, -DPA1, -DPB1, -DQA1, -DQB1 and -DRB1 loci in 105 patients with BP by Sanger sequence-based typing (SBT) method...
December 2, 2017: Journal of Dermatological Science
John Y W Lee, Assem Farag, Amira Tawdy, Lu Liu, Magdalene Michael, Ellie Rashidghamat, Sophia Aristodemou, Chao-Kai Hsu, Michael A Simpson, Maddy Parsons, John A McGrath
No abstract text is available yet for this article.
December 2, 2017: Journal of Dermatological Science
Hyeongwon Choi, Dong-Jin Kim, Seungwoo Nam, Sunki Lim, Jae-Sung Hwang, Ki Sook Park, Hyun Sook Hong, Younsun Won, Min Kyung Shin, Eunkyung Chung, Youngsook Son
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by intense pruritus and eczematous lesion. Substance P (SP) is an 11-amino-acid endogenous neuropeptide that belongs to the tachykinin family and several reports recently have supported the anti-inflammatory and tissue repairing roles of SP. OBJECTIVE: In this study, we investigated whether SP can improve AD symptoms, especially the impaired skin barrier function, in 2, 4, 6-trinitrochlorobenzene (TNCB)-induced chronic dermatitis of NC/Nga mice or not...
December 1, 2017: Journal of Dermatological Science
F Huet, M Severino-Freire, J Chéret, O Gouin, J Praneuf, O Pierre, L Misery, C Le Gall-Ianotto
Atopic dermatitis (AD) is a chronic inflammatory skin disease causing a strong impact on quality of life. Its pathophysiology is the result of complex interactions involving immunological, genetic and environmental factors. Although there are several published in vitro three-dimensional models mimicking AD, none of them have taken all these pathophysiological features into account; thus, finding the right model may be complicated. This paper reviews the literature on the different reconstructed epidermis models of AD as well as their relevance...
December 1, 2017: Journal of Dermatological Science
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