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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/27894778/stem-cells-in-psoriasis
#1
REVIEW
Ruixia Hou, Junqin Li, Xuping Niu, Ruifeng Liu, Wenjuan Chang, Xincheng Zhao, Qiang Wang, Xinhua Li, Guohua Yin, Kaiming Zhang
Psoriasis is a complex chronic relapsing inflammatory disease. Although the exact mechanism remains unknown, it is commonly accepted that the development of psoriasis is a result of multi-system interactions among the epidermis, dermis, blood vessels, immune system, neuroendocrine system, metabolic system, and hematopoietic system. Many cell types have been confirmed to participate in the pathogenesis of psoriasis. Here, we review the stem cell abnormalities related to psoriasis that have been investigated recently...
November 15, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27876252/clinical-characteristics-in-cholinergic-urticaria-with-palpebral-angioedema-report-of-15-cases
#2
LETTER
Ken Washio, Atsushi Fukunaga, Minako Onodera, Mayumi Hatakeyama, Kumiko Taguchi, Kanako Ogura, Tatsuya Horikawa, Chikako Nishigori
No abstract text is available yet for this article.
November 11, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27866791/mesenchymal-stem-cells-the-roles-and-functions-in-cutaneous-wound-healing-and-tumor-growth
#3
REVIEW
Sei-Ichiro Motegi, Osamu Ishikawa
Mesenchymal stem cells (MSCs) are bone marrow-derived non-hematopoietic progenitor cells. MSCs are able to differentiate into various types of cells, including chondrocytes, adipocytes, osteocytes, myocytes, endothelial cells, and keratinocytes. There is increasing evidence that MSCs might be located external to the vasculature, and that perivascular cells in the skin, generally called as "pericytes", might include MSCs. It has been suggested that MSCs localized around blood vessels might migrate into wounds and contribute to the restoration of injured tissues...
November 11, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27876358/a-randomized-double-blind-trial-of-intravenous-immunoglobulin-for-bullous-pemphigoid
#4
Masayuki Amagai, Shigaku Ikeda, Takashi Hashimoto, Masato Mizuashi, Akihiro Fujisawa, Hironobu Ihn, Yasushi Matsuzaki, Mikio Ohtsuka, Hiroshi Fujiwara, Junichi Furuta, Osamu Tago, Jun Yamagami, Akiko Tanikawa, Hisashi Uhara, Akimichi Morita, Gen Nakanishi, Mamori Tani, Yumi Aoyama, Eiichi Makino, Masahiko Muto, Motomu Manabe, Takayuki Konno, Satoru Murata, Seiichi Izaki, Hideaki Watanabe, Yukie Yamaguchi, Setsuko Matsukura, Mariko Seishima, Koji Habe, Yuichi Yoshida, Sakae Kaneko, Hajime Shindo, Kimiko Nakajima, Takuro Kanekura, Kenzo Takahashi, Yasuo Kitajima, Koji Hashimoto
BACKGROUND: Patients with steroid-resistant bullous pemphigoid (BP) require an appropriate treatment option. OBJECTIVE: A multicenter, randomized, placebo-controlled, double-blind trial was conducted to investigate the therapeutic effect of high-dose intravenous immunoglobulin (IVIG; 400mg/kg/day for 5days) in BP patients who showed no symptomatic improvement with prednisolone (≥0.4mg/kg/day) administered. METHODS: We evaluated the efficacy using the disease activity score on day15 (DAS15) as a primary endpoint, and changes in the DAS over time, the anti-BP180 antibody titer, and safety for a period of 57days as secondary endpoints...
November 9, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27865567/preconceptional-and-perinatal-exposure-to-traffic-related-air-pollution-and-eczema-in-preschool-children
#5
Chan Lu, Linjing Deng, Cuiyun Ou, Hong Yuan, Xiang Chen, Qihong Deng
BACKGROUND: Evidence linking prenatal exposure to outdoor air pollution with eczema in early childhood is scare, and the role of components of air pollution and exposure timing remains unclear. OBJECTIVES: We investigated the association between exposure to air pollution during preconceptional and perinatal period and the risk of eczema in preschool children. METHODS: We conducted a prospective cohort study of 2598 children aged 3-6 years in Changsha, China...
November 9, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27789198/co-regulation-of-cxcl1-and-versican-in-the-inflammatory-response-to-uvb-induced-reactive-oxygen-species-in-skin-photo-tumorigenesis
#6
LETTER
Chihiro Takemori, Makoto Kunisada, Flandiana Yogianti, Sugako Oka, Kunihiko Sakumi, Ryusuke Ono, Yusaku Nakabeppu, Chikako Nishigori
No abstract text is available yet for this article.
October 20, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27810232/potential-role-of-il-17-producing-cd4-cd8-double-negative-%C3%AE-%C3%AE-t-cells-in-psoriatic-skin-inflammation-in-a-tpa-induced-stat3c-transgenic-mouse-model
#7
Azumi Ueyama, Chihiro Imura, Yasuyuki Fusamae, Kenichiro Tsujii, Yoko Furue, Miwa Aoki, Minoru Suzuki, Tomohiko Okuda, Itsuki Oshima, Kiyoshi Yasui, Michitaka Shichijo, Mina Yamamoto
BACKGROUND: Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders and is accompanied by erythematous scaly plaques. There is growing evidence that the IL-23/Th17 axis plays a critical role in development of the disease. It was recently shown that in addition to CD4(+) Th17 cells, various IL-17-producing cell subsets such as CD8(+) Tc17 cells, dermal γδ T cells, and innate lymphoid cells are also involved in the development of psoriatic inflammation in humans...
October 19, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27780627/first-japanese-case-of-congenital-generalized-hypertrichosis-with-a-copy-number-variation-on-chromosome-17q24
#8
LETTER
Ryota Hayashi, Kazue Yoshida, Riichiro Abe, Hironori Niizeki, Yutaka Shimomura
No abstract text is available yet for this article.
October 19, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27802907/a-newly-revealed-il36rn-mutation-in-sibling-cases-complements-our-il36rn-mutation-statistics-for-generalized-pustular-psoriasis
#9
LETTER
Takuya Takeichi, Yaei Togawa, Yusuke Okuno, Rieko Taniguchi, Michihiro Kono, Hiroyuki Matsue, Kazumitsu Sugiura, Masashi Akiyama
No abstract text is available yet for this article.
October 18, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27839630/nuclear-expression-of-il-33-in-epidermal-keratinocytes-promotes-wound-healing-in-mice
#10
Tomoyuki Oshio, Mayumi Komine, Hidetoshi Tsuda, Shin-Ichi Tominaga, Hirohisa Saito, Susumu Nakae, Mamitaro Ohtsuki
BACKGROUND: Skin is the outermost tissue of the human body, and works as a mechanical, chemical, and biological barrier. The epidermis is the uppermost layer of the skin, and keratinocytes constitute the majority of epidermal cells. Wounds are disruptions of skin integrity, and cause tremendous disadvantages to humans; accordingly, rapid wound healing is very important. Interleukin (IL)-33 is expressed in barrier tissue cells, such as epithelial and endothelial cells. Upon injury, IL-33 is released to stimulate immune cells, functioning as an "alarmin...
October 17, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27771230/sox9-facilitates-proliferation-differentiation-and-lipogenesis-in-primary-cultured-human-sebocytes
#11
Ge Shi, Ting-Ting Wang, Juan-Hua Quan, Shi-Jie Li, Man-Feng Zhang, Pei-Yu Liao, Yi-Ming Fan
BACKGROUND: The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood. OBJECTIVE: We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis. METHODS: Sox9 expression was detected by immunohistochemistry in normal skin and acne lesion. Primary cultured human sebocytes were transfected with adenovirus expressing GFP-Sox9 or Sox9 microRNA...
October 13, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27771229/comparative-study-on-driver-mutations-in-primary-and-metastatic-melanomas-at-a-single-japanese-institute-a-clue-for-intra-and-inter-tumor-heterogeneity
#12
Tatsuya Kaji, Osamu Yamasaki, Minoru Takata, Masaki Otsuka, Toshihisa Hamada, Shin Morizane, Kenji Asagoe, Hiroyuki Yanai, Yoji Hirai, Hiroshi Umemura, Keiji Iwatsuki
BACKGROUND: Searching for driver mutations in melanoma is critical to understanding melanoma genesis, progression and response to therapy. OBJECTIVES: We aimed to investigate the frequency and pattern of driver mutations in Japanese primary and metastatic melanomas including cases of unknown primary origin, in relation to their clinicopathologic manifestations. METHODS: Seventy-seven samples from 60 patients with melanoma were screened for 70 driver mutations of 20 oncogenes by Sequenom MelaCarta MassARRAY, and the results for primary and metastatic melanomas were compared...
October 13, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27765435/alopecia-areata-what-s-new-in-epidemiology-pathogenesis-diagnosis-and-therapeutic-options
#13
REVIEW
Teruki Dainichi, Kenji Kabashima
Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is caused by autoimmune attack against the hair follicles. The precise pathomechanism, however, remains unknown. Here, we focus on the recent progress in multidisciplinary approaches to the epidemiology, pathogenesis, and new treatments of AA in 996 publications from January 2010 to July 2016, and provide an overview of the current understanding in clinical management and research directions...
October 11, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27765434/the-contribution-of-dermoscopy-to-early-excision-of-basal-cell-carcinoma-a-study-on-the-tumor-sizes-acquired-between-1998-and-2013-at-a-university-hospital-in-japan
#14
Sumiko Ishizaki, Masaru Tanaka, Itaru Dekio, Mizuki Sawada, Mariko Fujibayashi, Satoru Shimizu
No abstract text is available yet for this article.
October 8, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27720465/inhibition-of-aryl-hydrocarbon-receptor-signaling-and-induction-of-nrf2-mediated-antioxidant-activity-by-cinnamaldehyde-in-human-keratinocytes
#15
Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Chikage Mitoma, Masutaka Furue
BACKGROUND: Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE: To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS: Keratinocytes were used in this study because the skin is one of the organs most affected by dioxin and other environmental pollutants...
October 4, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27756516/differential-activation-behavior-of-dermal-dendritic-cells-underlies-the-strain-specific-th1-responses-to-single-epicutaneous-immunization
#16
Chih-Hung Lee, Jau-Shiuh Chen, Hsien-Ching Chiu, Chien-Hui Hong, Ching-Yi Liu, Yng-Cun Ta, Li-Fang Wang
BACKGROUND: Epicutaneous immunization with allergens is an important sensitization route for atopic dermatitis. We recently showed in addition to the Th2 response following single epicutaneous immunization, a remarkable Th1 response is induced in B6 mice, but not in BALB/c mice, mimicking the immune response to allergens in human non-atopics and atopics. OBJECTIVE: We investigated the underlying mechanisms driving this differential Th1 response between BALB/c and B6 mice...
October 3, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27726924/oral-administration-of-a-novel-ror%C3%AE-t-antagonist-attenuates-psoriasis-like-skin-lesion-of-two-independent-mouse-models-through-neutralization-of-il-17
#17
Mikiro Takaishi, Masayuki Ishizaki, Keisuke Suzuki, Takashi Isobe, Takaichi Shimozato, Shigetoshi Sano
BACKGROUND: Targeting the IL-17 pathway represents a highly effective strategy for the treatment of psoriasis, using antibodies against IL-17A and IL-17 receptor, suggesting that Th17 cells essentially contribute to development of psoriasis. Th17 differentiation depends on the key transcription factor, RORγt. OBJECTIVE: To develop a novel RORγt antagonist which is effective on psoriasis via oral administration. METHODS: A chemical library was screened using cell-based high-throughput methods, luciferase reporter assay, competitive binding assay, and T cell differentiation assay...
October 3, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27720466/differential-diagnosis-of-herpetiform-vesicles-by-a-non-invasive-molecular-method-using-crusts-or-blister-roofs-sensitivity-specificity-and-likelihood-ratio
#18
Tomoko Miyake, Takenobu Yamamoto, Yoji Hirai, Keiji Iwatsuki
No abstract text is available yet for this article.
October 3, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27743912/palmoplantar-pustular-psoriasis-pppp-is-characterized-by-activation-of-the-il-17a-pathway
#19
Robert Bissonnette, Judilyn Fuentes-Duculan, Shunya Mashiko, Xuan Li, Kathleen M Bonifacio, Inna Cueto, Mayte Suárez-Fariñas, Catherine Maari, Chantal Bolduc, Simon Nigen, Marika Sarfati, James G Krueger
BACKGROUND: Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis, which has significant negative impact on quality of life. The cellular and molecular inflammatory pathways involved in PPPP have not been well studied. OBJECTIVE: Study the expression of cytokines and chemokines involved in the IL-17/IL-23 axis in palmoplantar pustular psoriasis and other difficult to treat psoriasis areas (palms, scalp, elbows and lower legs). METHODS: Skin biopsies were performed on a total of 80 patients with PPPP, non-pustular palmoplantar psoriasis (NPPPP), or psoriasis located on elbows, knees and scalp as well as 10 healthy subjects...
September 29, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27743910/carbonylated-proteins-exposed-to-uva-and-to-blue-light-generate-reactive-oxygen-species-through-a-type-i-photosensitizing-reaction
#20
Taeko Mizutani, Hijiri Sumida, Yuki Sagawa, Yuri Okano, Hitoshi Masaki
BACKGROUND: Carbonylated proteins (CPs) are generated by the reaction of basic amino acid residues in proteins with aldehyde compounds produced during lipid peroxidation. CPs in the stratum corneum (SC) impact skin conditions such as skin moisture functions including water content and transepidermal water loss (TEWL). In addition, CPs can be frequently seen in the SC from sun-exposed sites compared with sun-protected sites. OBJECTIVE: The aim of this study was to reveal whether CPs could be a generation source of reactive oxygen species (ROS) in the SC following exposure to ultraviolet (UV) radiation and to identify the type of ROS and its generation mechanism...
September 28, 2016: Journal of Dermatological Science
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