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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/28927967/removal-of-nontoxic-foreign-material-to-the-surface-by-cultured-human-epidermal-keratinocytes-in-an-epidermal-equivalent-model
#1
LETTER
Junichi Kumamoto, Shinobu Nakanishi, Yuki Umino, Mitsuhiro Denda
No abstract text is available yet for this article.
September 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28899582/fgf2-mediated-attenuation-of-myofibroblast-activation-is-modulated-by-distinct-mapk-signaling-pathways-in-human-dermal-fibroblasts
#2
David M Dolivo, Sara A Larson, Tanja Dominko
BACKGROUND: Previous human and animal studies have demonstrated the ability of exogenously administered basic fibroblast growth factor (FGF2) to act as an antifibrotic agent in the skin. Though the activity of FGF2 as an anti-scarring agent is well-established for fibrotic skin wounds, the mechanisms by which FGF2 exerts these actions are not entirely understood. Canonical FGF2 signaling proceeds in part via FGFR/MAPK pathways in human dermal fibroblasts, and FGF2 has been described to prevent or reverse the fibroblast-to-myofibroblast transition, which is driven by TGFβ signaling and understood to be an important step in the formation of a fibrotic scar in vivo...
September 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28855069/corrigendum-to-letter-to-the-editor-ultraviolet-b-uvb-induces-development-of-early-melanocytic-progenitors-via-increased-oxidative-stress-in-vitro-suggesting-the-use-of-antioxidants-after-regimentation-in-uvb-phototherapy-for-vitiligo-j-dermatol-sci-87-2017
#3
Sebastian Yu, Hsin-Su Yu, Hsiao-Chi Lai, Ching-Shuang Wu, Hui-Ying Jheng, Cheng-Che Lan
No abstract text is available yet for this article.
August 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28911799/effects-of-glucocorticoids-on-stratum-corneum-lipids-and-function-in-human-skin-a-detailed-lipidomic-analysis
#4
Mads A Røpke, Cristina Alonso, Sora Jung, Hanne Norsgaard, Claudia Richter, Maxim E Darvin, Thomas Litman, Annika Vogt, Jürgen Lademann, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND: Topical glucocorticoids (GCs) are known to induce atrophy of human skin including thinning of epidermal and dermal compartments by influencing keratinocyte proliferation and synthesis of extracellular matrix proteins. GCs are also known to reduce skin barrier integrity but little is known about the changes in lipid composition in human skin following topical administration of GCs. OBJECTIVE: This study investigated the effects of GCs on stratum corneum (SC) function and lipid profile of human skin in vivo...
August 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28882477/possible-role-of-tropomyosin-receptor-kinase-fused-gene-on-skin-collagen-remodeling
#5
LETTER
Jung-Min Shin, So-Jung Kong, Young-Ah Shin, Yun-Hee Chang, Ji-Young Kim, Kyung-Cheol Sohn, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Young Lee
No abstract text is available yet for this article.
August 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28870516/a-docking-model-of-dapsone-bound-to-hla-b-13-01-explains-the-risk-of-dapsone-hypersensitivity-syndrome
#6
Hideaki Watanabe, Yurie Watanabe, Yasuya Tashiro, Taisei Mushiroda, Takeshi Ozeki, Hideo Hashizume, Hirohiko Sueki, Toshinori Yamamoto, Naoko Utsunomiya-Tate, Hiroaki Gouda, Yoshio Kusakabe
BACKGROUND: Dapsone (4,4'-diaminodiphenylsulfone) has been widely used for the treatment of infections such as leprosy. Dapsone hypersensitivity syndrome (DHS) is a major side effect, developing in 0.5-3.6% of patients treated with dapsone, and its mortality rate is ∼10%. Recently, human leukocyte antigen (HLA)-B*13:01 was identified as a marker of susceptibility to DHS. OBJECTIVES: To investigate why HLA-B*13:01 is responsible for DHS from a structural point of view...
August 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28843624/sorafenib-stimulates-human-skin-type-mast-cell-degranulation-and-maturation
#7
Yukari Mizukami, Koji Sugawara, Yukimi Kira, Daisuke Tsuruta
BACKGROUND: Sorafenib is a multi-kinase inhibitor for treating advanced hepatocellular and renal cell carcinomas by targeting various types of receptors and signaling molecules, including vascular endothelial growth factor receptors, platelet-derived growth factor receptor, and Raf-1. Sorafenib may cause diverse cutaneous adverse reactions, including hand-foot reaction, facial and scalp eruptions, alopecia and pruritus. However, the mechanism of these adverse effects has not been well-investigated...
August 12, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28823644/9-phenanthrol-enhances-the-generation-of-an-cd8-t-cell-response-following-transcutaneous-immunization-with-imiquimod-in-mice
#8
Ann-Kathrin Hartmann, Pamela Aranda Lopez, Marek Zajac, Marc Freichel, Hansjörg Schild, Markus P Radsak, Michael Stassen
BACKGROUND: Transcutaneous immunization (TCI) is a non-invasive vaccination strategy targeting the skin-associated lymphoid tissue. Topical application of the TLR7 agonist imiquimod as adjuvant in combination with peptide antigens activates the innate immune system and mounts cytotoxic T lymphocyte (CTL) responses. OBJECTIVE: Based on the commercial 5% imiquimod-containing drug Aldara we aimed to develop an improved formulation with superior vaccination efficiencies...
August 12, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28823642/elevated-il-31-serum-levels-in-bullous-pemphigoid-patients-correlate-with-eosinophil-numbers-and-are-associated-with-bp180-ige
#9
LETTER
Mareen Salz, Stefanie Haeberle, Jochen Hoffmann, Alexander H Enk, Eva N Hadaschik
No abstract text is available yet for this article.
August 12, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28826690/confocal-raman-spectroscopy-in-vivo-measurement-of-physiological-skin-parameters-a-pilot-study
#10
Lisa Binder, Safoura SheikhRezaei, Andreas Baierl, Lukas Gruber, Michael Wolzt, Claudia Valenta
BACKGROUND: In vivo application of confocal Raman spectroscopy (CRS) allows non-invasive depth measurement of the skin. Thereby obtained knowledge of the skin composition is essential to reliably assess the actual skin state. Besides other components, the skin cholesterol concentration is of interest; however, little is known about its connection to the cholesterol concentration quantified in venous blood. OBJECTIVE: In this study, the skin composition of the volar forearm was characterised in vivo using CRS...
August 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28838617/the-skin-as-sensor-and-effector-organ-orchestrating-cutaneous-and-systemic-disease
#11
EDITORIAL
Alexander H Enk
No abstract text is available yet for this article.
August 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28822698/staphylococcus-aureus-from-atopic-dermatitis-skin-alters-cytokine-production-triggered-by-monocyte-derived-langerhans-cell
#12
Kazumasa Iwamoto, Masaya Moriwaki, Yoshie Niitsu, Masachika Saino, Shunsuke Takahagi, Junzo Hisatsune, Motoyuki Sugai, Michihiro Hide
BACKGROUND: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. The skin of patients with AD presents as a disbalance of the microbiome with a strong colonization by Staphylococcus aureus, which positively correlates with the severity of the disease. However, the effect of colonized S. aureus on the skin immune system has not been fully elucidated. OBJECTIVE: The aim of this study is to explore whether S. aureus isolated from AD skin is able to skew T cell responses via Langerhans cells (LC) as compared to a standard strain of S...
August 5, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28818497/drp1-regulates-mitochondrial-morphology-and-cell-proliferation-in-cutaneous-squamous-cell-carcinoma
#13
Shinya Kitamura, Teruki Yanagi, Keisuke Imafuku, Hiroo Hata, Riichiro Abe, Hiroshi Shimizu
BACKGROUND: Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. Recently, several studies have shown that Drp1 plays an important role in some cancers. However, little is known about Drp1 in cutaneous squamous cell carcinoma (SCC). OBJECTIVE: To investigate the role of Drp1 in the tumorigenesis of cutaneous SCCs. METHODS AND RESULTS: We investigated cell proliferation, cell cycle, mitochondrial morphology, and MAPK signaling pathway using cutaneous SCC A431 and DJM1 cells that were transfected with shRNA vectors targeting Drp1...
August 5, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28826691/cell-size-dependent-upregulation-of-hgf-expression-in-dermal-fibroblasts-impact-on-human-skin-connective-tissue-aging
#14
Zhaoping Qin, Christal A Worthen, Taihao Quan
BACKGROUND: Aged human skin is primarily attributable to loss of collagen, the main structural component of skin. Hepatocyte growth factor (HGF) acts as an anti-fibrotic factor by suppression of collagen production. It is not known whether HGF is involved in age-related collagen deficit in human skin. OBJECTIVE: The objective of this study was to investigate the expression of HGF in human skin, and the underlying mechanisms of age-related elevation of HGF expression...
August 4, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28807557/the-role-of-toll-like-receptor-3-in-chronic-contact-hypersensitivity-induced-by-repeated-elicitation
#15
Risa Yasuike, Risa Tamagawa-Mineoka, Mayumi Ueta, Naomi Nakamura, Shigeru Kinoshita, Norito Katoh
BACKGROUND: Accumulating evidence suggests that Toll-like receptor (TLR)-3 signaling is involved in non-infectious immune and inflammatory reactions as well as in viral infections. The skin of patients with atopic dermatitis (AD) is often infected with virus and bacteria, leading to the aggravation of atopic symptoms. These findings suggest TLR3 signaling may be involved in the pathogenesis of AD, but the exact role of TLR3 in AD remains to be defined. OBJECTIVE: The purpose of this study was to investigate the role of TLR3 in chronic contact hypersensitivity reactions induced by repeated elicitation, resembling the features of AD...
August 4, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28797686/clinical-application-of-next-generation-sequencing-for-the-diagnosis-of-segmental-neurofibromatosis
#16
LETTER
Younhee Ko, Chelho Lee, Hyunjoo Lee, Minjung Lee, Jin-Sung Lee
No abstract text is available yet for this article.
July 28, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28793966/delivery-of-antioxidant-enzymes-for-prevention-of-ultraviolet-irradiation-induced-epidermal-damage
#17
LETTER
Brianna Hammiller, Bala Vamsi K Karuturi, Christina Miller, Matti Holmes, Vinod Labhasetwar, Gary Madsen, Laura A Hansen
No abstract text is available yet for this article.
July 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28838616/molecular-analysis-of-immunoglobulin-variable-genes-supports-a-germinal-center-experienced-normal-counterpart-in-primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type
#18
Anne Pham-Ledard, Martina Prochazkova-Carlotti, Mélanie Deveza, Marie-Pierre Laforet, Marie Beylot-Barry, Béatrice Vergier, Marie Parrens, Jean Feuillard, Jean-Philippe Merlio, Nathalie Gachard
BACKGROUND: Immunophenotype of primary cutaneous diffuse large B-cell lymphoma, leg-type (PCLBCL-LT) suggests a germinal center-experienced B lymphocyte (BCL2+ MUM1+ BCL6+/-). OBJECTIVES: As maturation history of B-cell is "imprinted" during B-cell development on the immunoglobulin gene sequence, we studied the structure and sequence of the variable part of the genes (IGHV, IGLV, IGKV), immunoglobulin surface expression and features of class switching in order to determine the PCLBCL-LT cell of origin...
July 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28843623/antimicrobial-peptides-human-ll-37-and-%C3%AE-defensin-3-modulate-the-expression-of-nerve-elongation-factors-in-human-epidermal-keratinocytes
#19
LETTER
Yoshie Umehara, Yayoi Kamata, Mitsutoshi Tominaga, François Niyonsaba, Hideoki Ogawa, Kenji Takamori
No abstract text is available yet for this article.
July 23, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28764861/silencing-of-metallothionein-1a-gene-in-melanoma
#20
Yoshimasa Nobeyama, Hidemi Nakagawa
BACKGROUND: When a CpG island (CGI; a dense cluster of CpGs) located in the 5' region of a gene is methylated, its transcription is suppressed. Tumorigenesis of melanoma is associated with trace elements. Metallothionein 1A is closely associated with the metabolism of trace elements. However, little is known about the metallothionein 1A gene (MT1A) in melanoma. OBJECTIVE: The purpose is to reveal the methylation and expression status of MT1A in melanoma. METHODS: Quantitative real-time methylation-specific PCR (RT-MSP) and bisulfite sequencing were performed to examine MT1A methylation status...
July 21, 2017: Journal of Dermatological Science
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