journal
MENU ▼
Read by QxMD icon Read
search

Journal of Dermatological Science

journal
https://www.readbyqxmd.com/read/28427821/a-case-of-recessive-dystrophic-epidermolysis-bullosa-with-a-novel-c-6885_6898del14-mutation-in-the-col7a1-gene
#1
LETTER
Satoru Shinkuma, Tae Masunaga, Saori Miyawaki, Shota Takashima, Ken Natsuga, Toshifumi Nomura, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu
No abstract text is available yet for this article.
April 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28433429/immunological-function-of-langerhans-cells-in-hiv-infection
#2
Takamitsu Matsuzawa, Youichi Ogawa, Kohji Moriishi, Shinji Shimada, Tatsuyoshi Kawamura
BACKGROUND: Langerhans cells (LCs) are one of the initial target cells for HIV following sexual exposure and they are productively infected by HIV. HIV-infected LCs migrate to the draining lymph nodes (dLNs) and transmit the virus to CD4(+) T cells, leading to the dissemination of HIV. In contrast with the role of LCs in initial HIV acquisition, little is known about the modulation of immune responses by HIV-infected LCs. OBJECTIVE: We aimed to elucidate the induction of HIV-specific CD8(+) T cells and regulatory T cells (Tregs), both of which play important roles in regulating the progression of HIV infection...
April 9, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28433430/complementary-effect-of-hydroquinone-and-retinoic-acid-on-corneocyte-desquamation-with-their-combination-use
#3
Kyung Ah Cheong, Tae Ryong Lee, Ai-Young Lee
BACKGROUND: Retinoic acid (RA) enhances skin-lightening capabilities of hydroquinone (HQ), at least in part, by facilitating desquamation which leads to increase penetration of HQ. The desquamation also affects skin irritation levels. The mechanism of RA-induced desquamation, however, has not been completely explored and no such data has been available for HQ uses. OBJECTIVE: To examine the role of HQ, RA, and their combination in the desquamation. METHODS: Primary cultured normal human keratinocytes, which were treated with HQ and/or RA in presence or absence of serine-specific inhibitor Kazal type5 (SPINK5)/lympho-epithelial Kazal-type-related inhibitor (LEKTI) knockdown or recombinant human SPINK5/LEKTI, and biopsied skin samples applied with HQ or RA were examined...
April 7, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28427820/the-ovariectomized-mouse-simulates-the-pathophysiology-of-postmenopausal-female-pattern-hair-loss
#4
LETTER
Yujiro Endo, Masato Takahashi, Yuko Obayashi, Tetsushi Serizawa, Michiaki Murakoshi, Manabu Ohyama
No abstract text is available yet for this article.
April 7, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28404453/wip1-inhibition-leads-to-severe-pro-inflammatory-phenotype-in-skin-in-response-to-chemical-irritation
#5
LETTER
Bogdan B Grigorash, Burhan Uyanik, Elena Y Kochetkova, Anastasia R Goloudina, Oleg N Demidov
No abstract text is available yet for this article.
April 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28416366/2-year-animal-carcinogenicity-results-for-crisaborole-a-novel-phosphodiesterase-4-inhibitor-for-atopic-dermatitis
#6
Vic Ciaravino, Dina Coronado, Cheryl Lanphear, Sanjay Chanda
BACKGROUND: Crisaborole is a novel, topical nonsteroidal, anti-inflammatory, phosphodiesterase 4 (PDE4) inhibitor for the treatment of mild to moderate atopic dermatitis. OBJECTIVE: As part of a nonclinical safety testing program, these 2-year studies tested the carcinogenic potential of crisaborole. METHODS: Crisaborole ointment, 2%, 5%, or 7%, was applied once daily topically to mice, and crisaborole was administered orally to rats at doses of 30, 100, or 300mg/kg/day for up to 104 weeks...
March 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28404454/anacardic-acid-ameliorates-ultraviolet-irradiation-induced-damage-to-human-skin
#7
LETTER
Min-Kyoung Kim, Mi Hee Shin, Yeon Kyung Kim, Ha Young Kim, Yu Ri Lee, Dong Hun Lee, Jin Ho Chung
No abstract text is available yet for this article.
March 30, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28431948/serum-peptides-as-putative-modulators-of-inflammation-in-psoriasis
#8
Tetsuhiko Matsuura, Masaaki Sato, Kouhei Nagai, Toshiyuki Sato, Mitsumi Arito, Kazuki Omoteyama, Naoya Suematsu, Kazuki Okamoto, Tomohiro Kato, Yoshinao Soma, Manae S Kurokawa
BACKGROUND: Psoriasis is a refractory inflammatory disease, however, its pathophysiology is still not fully understood. OBJECTIVE: We tried to identify novel serum peptides associated with the pathophysiology of psoriasis. METHODS: Serum peptides from 24 patients with psoriasis vulgaris (PV), 10 patients with psoriatic arthritis (PsA), 14 patients with atopic dermatitis (AD), and 23 healthy control (HC) subjects were analyzed by mass spectrometry...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28385331/generalized-verrucosis-and-abnormal-t-cell-activation-due-to-homozygous-taok2-mutation
#9
Vered Molho-Pessach, Yuval Ramot, Maxim Mogilevsky, Leonor Cohen-Daniel, Eli M Eisenstein, Abdulsalam Abu-Libdeh, Ihab Siam, Michael Berger, Rotem Karni, Abraham Zlotogorski
BACKGROUND: Generalized verrucosis (GV) is a chronic and progressive cutaneous human papillomavirus (HPV) infection resulting in multiple warts and associated with acquired or genetic immune defects. We identified a consanguineous Arab family manifesting GV and recurrent bacterial and viral infections, in association with inflammatory bowel disease (IBD). OBJECTIVE: To identify the mutated gene responsible for GV, recurrent infections and IBD, in this family. METHODS: Flow cytometry of peripheral blood mononuclear cells was performed, as well as proliferation and cell cycle assays of T cells...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28381343/podoplanin-expression-in-peritumoral-keratinocytes-predicts-aggressive-behavior-in-extramammary-paget-s-disease
#10
Zaigen Cho, Eiichi Konishi, Mai Kanemaru, Taro Isohisa, Takahiro Arita, Minako Kawai, Miho Tsutsumi, Hiromi Mizutani, Hideya Takenaka, Toshiyuki Ozawa, Daisuke Tsuruta, Norito Katoh, Jun Asai
BACKGROUND: Recent studies have demonstrated podoplanin expression in several tumors, which has been associated with lymph node metastasis and poor prognosis. Podoplanin expression in peritumoral cells such as cancer-associated fibroblasts also correlates with tumor progression in several cancers. However, podoplanin expression and its association with extramammary Paget's disease (EMPD) remain unclear. OBJECTIVE: In this study, we examined whether the presence of podoplanin expression in tumor cells or peritumoral basal keratinocytes correlated with aggressive behavior in patients with EMPD and investigated the mechanisms of podoplanin-mediated tumor invasion in this disorder...
March 27, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28377026/mcpip1-contributes-to-the-inflammatory-response-of-uvb-treated-keratinocytes
#11
Beata Bugara, Piotr Konieczny, Agnieszka Wolnicka-Glubisz, Leopold Eckhart, Heinz Fischer, Lukasz Skalniak, Julia Borowczyk-Michalowska, Justyna Drukala, Jolanta Jura
BACKGROUND: Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1), also known as regnase-1, negatively regulates many cellular processes including the cellular response to inflammatory agents, differentiation, viability, and proliferation. It possesses a PilT N-terminus (PIN) domain that is directly involved in regulating the stability of transcripts and miRNAs by recognizing stem loop structures and degrading them by endonucleolytic cleavage. OBJECTIVE: We investigated the role of MCPIP1 in the response of human primary keratinocytes to UVB stress...
March 25, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28351505/corrigendum-to-p62-modulates-the-intrinsic-signaling-of-uvb-induced-apoptosis-journal-of-dermatological-science-83-2016-226-233
#12
Sachiko Ito, Shintaro Kimura, Eiji Warabi, Yasuhiro Kawachi, Masanobu Yamatoji, Fumihiko Uchida, Naomi Ishibashi-Kanno, Kenji Yamagata, Shogo Hasegawa, Junichi Shoda, Katsuhiko Tabuchi, Satoshi Sakai, Hiroki Bukawa, Mitsuru Sekido, Toru Yanagawa
No abstract text is available yet for this article.
March 25, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28390782/anti-melanogenic-activity-of-phytosphingosine-via-the-modulation-of-the-microphthalmia-associated-transcription-factor-signaling-pathway
#13
Eun Jeong Jang, Yoonho Shin, Hyen Joo Park, Donghwa Kim, Cholomi Jung, Ji-Young Hong, Sanghee Kim, Sang Kook Lee
BACKGROUND: Microphthalmia-associated transcription factor (MITF) suppresses the expression of enzymes controlling the production of melanin. Phytosphingosine is a well-known cosmetic agent, but its anti-melanogenic activity and mechanism of action remain unclear. OBJECTIVE: This study was designed to investigate the effects of phytosphingosine on melanin synthesis and elucidate the plausible mechanism of actions in vitro and ex vivo systems. METHODS: Melanin content, cell viability, tyrosinase activity, p-CREB DNA binding activity, and the protein gene expression levels of the enzymes and proteins involved in melanogenesis were measured with the treatment of phytosphingosine...
March 23, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28366435/efficacy-and-safety-of-omalizumab-in-japanese-and-korean-patients-with-refractory-chronic-spontaneous-urticaria
#14
Michihiro Hide, Hae-Sim Park, Atsuyuki Igarashi, Young-Min Ye, Tae-Bum Kim, Akiko Yagami, Jooyoung Roh, Jae-Hyun Lee, Yuko Chinuki, Sang Woong Youn, Soo-Keol Lee, Naoko Inomata, Jeong-Hee Choi, Atsushi Fukunaga, Junyi Wang, Soichiro Matsushima, Steve Greenberg, Sam Khalil
BACKGROUND: Many patients with chronic spontaneous/idiopathic urticaria (CSU/CIU) do not respond adequately to treatment with non-sedating H1 antihistamines (H1AH). There are limited studies on use of omalizumab as add-on therapy for treatment of CSU in an Asian population. OBJECTIVE: The POLARIS study (NCT02329223), representing the first randomized, double-blind, placebo-controlled phase III trial of omalizumab for CSU in an Eastern Asian population, evaluated efficacy and safety of omalizumab as add-on therapy for treatment of CSU...
March 21, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28365082/vascular-psoriasis-area-severity-index-a-dermoscopic-standard-technique-for-assessing-severity-psoriasis-and-therapeutic-management
#15
LETTER
M Carlesimo, V Garelli, M C Fortuna, G De Vita, L Sorriso-Valvo, F Buccolini, A Melini, D Di Nunno, G Pranteda, A Rossi
No abstract text is available yet for this article.
March 21, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28385330/a-similar-local-immune-and-oxidative-stress-phenotype-in-vitiligo-and-halo-nevus
#16
Yuqi Yang, Shuli Li, Guannan Zhu, Qian Zhang, Gang Wang, Tianwen Gao, Chunying Li, Lin Wang, Zhe Jian
BACKGROUND: Vitiligo and halo nevus are two common T-cell-mediated skin disorders. Although autoimmunity has been suggested to be involved in both diseases, the relationship between vitiligo and halo nevus is not fully understood. OBJECTIVE: The aim of the current study was to investigate whether vitiligo and halo nevus share the same immunological and oxidative stress response. METHODS: Infiltrations of T cells, and expressions of chemokine receptors (CXCR3, CCR4, CCR5) and cytotoxic markers (Granzyme B, Perforin) in the lesions of vitiligo and halo nevus were examined by immunohistochemistry...
March 19, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28330775/novel-interferon-%C3%AE-enzyme-linked-immunospot-assay-using-activated-cells-for-identifying-hypersensitivity-inducing-drug-culprits
#17
Kenichi Kato, Asami Kawase, Hiroaki Azukizawa, Takaaki Hanafusa, Yukinobu Nakagawa, Hiroyuki Murota, Shimon Sakaguchi, Hideo Asada, Ichiro Katayama
BACKGROUND: The drug-induced lymphocyte stimulation test (DLST), also referred to as lymphocyte transformation test (LTT), is used to identify the culprit drug in cases of cutaneous adverse drug reactions (cADR). Although DLST is a widely used in vitro test, its sensitivity and specificity are unsatisfactory. Recent reports suggest that the detection of drug-induced interferon (IFN)-γ production using enzyme-linked immunoSpot (ELISpot) assay (conventional IFN-γ ELISpot) is useful for identifying culprit drugs in cADR cases...
March 14, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28342698/targeted-exome-sequencing-and-chromosomal-microarray-for-the-molecular-diagnosis-of-nevoid-basal-cell-carcinoma-syndrome
#18
Yoshihiro Matsudate, Takuya Naruto, Yumiko Hayashi, Mitsuyoshi Minami, Mikiko Tohyama, Kenji Yokota, Daisuke Yamada, Issei Imoto, Yoshiaki Kubo
BACKGROUND: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder mainly caused by heterozygous mutations of PTCH1. In addition to characteristic clinical features, detection of a mutation in causative genes is reliable for the diagnosis of NBCCS; however, no mutations have been identified in some patients using conventional methods. OBJECTIVE: To improve the method for the molecular diagnosis of NBCCS. METHODS: We performed targeted exome sequencing (TES) analysis using a multi-gene panel, including PTCH1, PTCH2, SUFU, and other sonic hedgehog signaling pathway-related genes, based on next-generation sequencing (NGS) technology in 8 cases in whom possible causative mutations were not detected by previously performed conventional analysis and 2 recent cases of NBCCS...
March 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28330776/topical-application-of-glycolic-acid-suppresses-the-uvb-induced-il-6-il-8-mcp-1-and-cox-2-inflammation-by-modulating-nf-%C3%AE%C2%BAb-signaling-pathway-in-keratinocytes-and-mice-skin
#19
Sheau-Chung Tang, Pei-Yun Liao, Sung-Jen Hung, Jheng-Siang Ge, Shiou-Mei Chen, Ji-Ching Lai, Yu-Ping Hsiao, Jen-Hung Yang
BACKGROUND: Glycolic acid (GA), commonly present in fruits, has been used to treat dermatological diseases. Extensive exposure to solar ultraviolet B (UVB) irradiation plays a crucial role in the induction of skin inflammation. The development of photo prevention from natural materials represents an effective strategy for skin keratinocytes. OBJECTIVE: The aim of this study was to investigate the molecular mechanisms underlying the glycolic acid (GA)-induced reduction of UVB-mediated inflammatory responses...
March 11, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28404452/agrimonia-pilosa-leaf-extract-accelerates-skin-barrier-restoration-by-activation-of-transient-receptor-potential-vanilloid-3
#20
LETTER
Yu-Ran Nam, Hyun Jong Kim, Young-Mi Kim, Young-Won Chin, Hyo Sang Bae, Woo Kyung Kim, Joo Hyun Nam
No abstract text is available yet for this article.
March 10, 2017: Journal of Dermatological Science
journal
journal
30519
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"