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Journal of Dermatological Science

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https://www.readbyqxmd.com/read/30017509/phenotypic-and-lipidomic-characterization-of-primary-human-epidermal-keratinocytes-exposed-to-simulated-solar-uv-radiation
#1
Núria Dalmau, Nathalie Andrieu-Abadie, Romà Tauler, Carmen Bedia
BACKGROUND: Ultraviolet (UV) radiation is known to be one of the most important environmental hazards acting on the skin. The most part of UV radiation is absorbed in the epidermis, where keratinocytes are the most abundant and exposed cell type. Lipids have an important role in skin biology, not only for their important contribution to the maintenance of the permeability barrier but also for the production and storage of energy, membrane organization and cell signalling functions. However, the effects on the lipid composition of keratinocytes under UV radiation are little explored...
July 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/30005897/substantial-evidence-for-the-rhododendrol-induced-generation-of-hydroxyl-radicals-that-causes-melanocyte-cytotoxicity-and-induces-chemical-leukoderma
#2
Yu Gabe, Akimitsu Miyaji, Masahiro Kohno, Akira Hachiya, Shigeru Moriwaki, Toshihide Baba
BACKGROUND: Rhododendrol (4-(4-hydroxyphenyl)-2-butanol) has been used as a lightening/whitening cosmetic but was recently reported to induce leukoderma. Although rhododendrol has been shown to be transformed by tyrosinase to hydroxyl-rhododendrol, which is cytotoxic to melanocytes, its detailed mechanism of action including the involvement of reactive oxygen species is not clearly understood. OBJECTIVE: To confirm the relationship of hydroxyl radical generation to melanocyte cytotoxicity induced by rhododendrol, this study was performed...
June 27, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29935789/variation-in-the-rptn-gene-may-facilitate-straight-hair-formation-in-europeans-and-east-asians
#3
LETTER
Ewelina Pośpiech, Soong Deok Lee, Magdalena Kukla-Bartoszek, Joanna Karłowska-Pik, Anna Woźniak, Michał Boroń, Magdalena Zubańska, Agnieszka Bronikowska, Sae Rom Hong, Ji Hyun Lee, Anna Wojas-Pelc, Hwan Young Lee, Magdalena Spólnicka, Wojciech Branicki
No abstract text is available yet for this article.
June 20, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/30007837/four-novel-recql4-mutations-in-four-chinese-patients-with-rothmund-thomson-syndrome-and-analysis-of-recql4-mrna-expression-level-in-one-typical-patient
#4
LETTER
Tingmei Wang, Luzhu Chen, Qiuyun She, Yingying Dong, Yunhua Deng
No abstract text is available yet for this article.
June 19, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29933899/the-development-of-induced-pluripotent-stem-cell-derived-mesenchymal-stem-stromal-cells-from-normal-human-and-rdeb-epidermal-keratinocytes
#5
Chihiro Nakayama, Yasuyuki Fujita, Wakana Matsumura, Inkin Ujiie, Shota Takashima, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu
BACKGROUND: Epidermolysis bullosa (EB) is a group of hereditary disorders caused by mutations in the genes encoding structural molecules of the dermal-epidermal junction (DEJ). Cell-based therapies such as allogeneic mesenchymal stem/stromal cell (MSC) transplantation have recently been explored for severe EB types, such as recessive dystrophic EB (RDEB). However, hurdles exist in current MSC-based therapies, such as limited proliferation from a single cell source and limited cell survival due to potential allogenic rejection...
June 18, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29933898/-r-pulegone-suppresses-allergic-and-inflammation-responses-on-2-4-dinitrochlorobenzene-induced-atopic-dermatitis-in-mice-model
#6
You Yeon Choi, Mi Hye Kim, Haesu Lee, Si Yeon Jo, Woong Mo Yang
BACKGROUND: (R)-(+)-pulegone (PLG), a biotransformation of monoterpene ketones, is one of essential oils of Labiatae family. Although PLG was reported to have anti-inflammatory and anti-histamine effects, the therapeutic effects of PLG on atopic dermatitis (AD) have not been reported yet. OBJECTIVE: This study investigated the anti-AD effects and underlying mechanisms of PLG in AD-induced mice. METHODS: BALB/c male mice were challenged with 2, 4-dinitrochlorobenzene (DNCB, 1%) to induce AD...
June 12, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29914851/integrative-methylome-and-transcriptome-analysis-to-dissect-key-biological-pathways-for-psoriasis-in-chinese-han-population
#7
Lili Tang, Yuyan Cheng, Caihong Zhu, Chao Yang, Lu Liu, Yuanjing Zhang, Leilei Wen, Xuejun Zhang, Fusheng Zhou, Sen Yang
BACKGROUND: Recent studies have revealed that DNA methylation (DNAm) could modulate gene expression in psoriasis (Ps). However, the relationship between whole-genome DNAm and gene expression in Ps has not been studied yet. OBJECTIVES: To better characterize the relationship between DNAm and gene expression, and to identify biological pathways triggered by changes in methylation involved in the pathogenesis of Ps. METHODS: Differentially methylated sites (DMSs) and differentially expressed genes (DEGs) were analysed by comparing 20 involved psoriatic (PP) skin, 20 uninvolved psoriatic (PN) skin and 20 normal (NN) skin biopsies...
June 9, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29885761/erratum-to-the-uva-induced-long-non-coding-rna-gs1-600g8-5-regulates-the-expression-of-il-8-j-dermatol-sci-90-june-3-2018-363-366
#8
Kazuyuki Yo, Thomas M Rünger
No abstract text is available yet for this article.
June 6, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29887490/abca12-mutations-in-patients-with-autosomal-recessive-congenital-ichthyosis-evidence-of-a-founder-effect-in-the-spanish-population-and-phenotype-genotype-implications
#9
LETTER
Uxia Esperón-Moldes, Manuel Ginarte, Laura Rodríguez-Pazos, Laura Fachal, Tomás Pozo, Jesús Luelmo Aguilar, Javier Del Boz González, Ana Martín Santiago, Ana Vega
No abstract text is available yet for this article.
June 5, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29885760/trp63-tp63-loss-accelerates-skin-tumorigenesis-through-activation-of-wnt-%C3%AE-catenin-signaling
#10
LETTER
Senthilnath Lakshmanachetty, Velmurugan Balaiya, Linda K Johnson, Maranke I Koster
No abstract text is available yet for this article.
June 1, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29903654/anti-pruritic-and-anti-inflammatory-effects-of-oxymatrine-in-a-mouse-model-of-allergic-contact-dermatitis
#11
Xiaoyun Xu, Wei Xiao, Zhe Zhang, Jianhao Pan, Yixi Yan, Tao Zhu, Dan Tang, Kaihe Ye, Manish Paranjpe, Lintao Qu, Hong Nie
BACKGROUND: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory disease of the skin. As a result of the complex etiology in ACD, therapeutic compounds targeting refractory pruritus in ACD lack efficacy and lead to numerous side effects. OBJECTIVE: In this study, we investigated the anti-pruritic effects of oxymatrine (OMT) and explored its mechanism of action in a mouse model of ACD. METHOD: 72 male SPF C57BL/6 mice were randomly divided into control group, ACD model group, dexamethasone positive control group (0...
May 31, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29914850/treatment-with-tnf-%C3%AE-inhibitor-rectifies-m1-macrophage-polarization-from-blood-cd14-monocytes-in-patients-with-psoriasis-independent-of-stat1-and-irf-1-activation
#12
Shang-Hung Lin, Hung-Yi Chuang, Ji-Chen Ho, Chih-Hung Lee, Chang-Chun Hsiao
BACKGROUND: Psoriasis is a systemic inflammatory disease with dramatic responses to TNF-α inhibitors. TNF-α is mainly produced by macrophages. However, how macrophage polarization contributes to psoriasis remains unknown. OBJECTIVE: We aimed to investigate the molecular mechanisms of macrophage polarization in psoriasis. METHODS: 8 patients with moderate to severe psoriasis (Male/Female: 4/4, average age: 47.9 years old) and 8 healthy controls (Male/Female: 4/4, average age: 49...
May 29, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29866520/intragenic-copy-number-variation-within-human-epiplakin-1-eppk1-generates-variation-of-molecular-size-of-epiplakin
#13
LETTER
Kazushi Ishikawa, Mie Furuhashi, Takashi Sasaki, Jun Kudoh, Atsunari Tsuchisaka, Takashi Hashimoto, Takako Sasaki, Hidekatsu Yoshioka, Nobuoki Eshima, Haruna Matsuda-Hirose, Takashi Sakai, Yutaka Hatano, Sakuhei Fujiwara
No abstract text is available yet for this article.
May 24, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29857961/the-role-of-sex-determining-region-y-box-6-in-melanogenesis-in-alpaca-melanocytes
#14
Bin Du, Xuexian Liu, Pengqian Zhang, Junzhen Zhang, Kaiyuan Ji, Shuaipeng Hu, Shanshan Yang, Bo Liu, Ruiwen Fan
BACKGROUND: Sex-determining region Y-box (SOX) proteins function as transcriptional regulators. The derivation of melanocytes from nerve crest cells has been reported to depend on SOX proteins, including SOX10 and SOX5. Whether SOX6 is expressed and has a functional role in melanocytes is unknown. OBJECTIVE: We aimed to study the effect of transcription factor SOX6 on melanogenesis in alpaca melanocytes. METHODS: We verified the role of SOX6 in melanogenesis by overexpressing and inhibiting SOX6 in melanocytes...
May 23, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29807809/dnaja4-deficiency-enhances-nf-kappa-b-related-growth-arrest-induced-by-hyperthermia-in-human-keratinocytes
#15
Yu-Zhe Sun, Yi Ren, Yu-Jing Zhang, Yang Han, Yang Yang, Ya-Li Gao, Li-Li Zhu, Rui-Qun Qi, Hong-Duo Chen, Xing-Hua Gao
BACKGROUND: Hyperthermia is an effective treatment against cancer and human papillomavirus (HPV) infection. Previous studies have shown that heat shock proteins are crucial to the action of hyperthermia. OBJECTIVES: To examine the effects of hyperthermia in combination with DNAJA4-deficiency on human keratinocytes and Condyloma acumunatum (CA) tissues. METHODS: HaCaT cells were subjected to 44 °C (compared to 37 °C) waterbath for 30 min for stimulation...
May 23, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29857962/proteome-wide-changes-in-primary-skin-keratinocytes-exposed-to-diesel-particulate-extract-a-role-for-antioxidants-in-skin-health
#16
Pavithra Rajagopalan, Ankit P Jain, Vishalakshi Nanjappa, Krishna Patel, Kiran K Mangalaparthi, Niraj Babu, Nükhet Cavusoglu, Nita Roy, Jeremie Soeur, Lionel Breton, Akhilesh Pandey, Harsha Gowda, Aditi Chatterjee, Namita Misra
BACKGROUND: Skin acts as a protective barrier against direct contact with pollutants but inhalation and systemic exposure have indirect effect on keratinocytes. Exposure to diesel exhaust has been linked to increased oxidative stress. OBJECTIVE: To investigate global proteomic alterations in diesel particulate extract (DPE)/its vapor exposed skin keratinocytes. METHODS: We employed Tandem Mass Tag (TMT)-based proteomics to study effect of DPE/DPE vapor on primary skin keratinocytes...
May 21, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#17
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29776717/m2-macrophages-promote-wound-induced-hair-neogenesis
#18
Akira Kasuya, Taisuke Ito, Yoshiki Tokura
BACKGROUND: De novo hair regeneration occurs in scars of normal adult mice. This interesting phenomenon is termed as wound-induced hair neogenesis (WIHN). We hypothesized that M2 macrophages are crucially involved in WIHN. OBJECTIVE: To clarify the contribution of M2 macrophages to WIHN. METHOD: We established a mouse model of WIHN. A full thickness skin excision was implemented on the back of C57BL/6 (B6) mice. Newly developing hair follicles were detected by a whole-mount assay...
May 12, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29764717/mitochondrial-damage-and-cytoskeleton-reorganization-in-human-dermal-fibroblasts-exposed-to-artificial-visible-light-similar-to-screen-emitted-light
#19
Adeline Rascalou, Jérôme Lamartine, Pauline Poydenot, Frédéric Demarne, Nicolas Bechetoille
BACKGROUND: Artificial visible light is everywhere in modern life. Social communication confronts us with screens of all kinds, and their use is on the rise. We are therefore increasingly exposed to artificial visible light, the effects of which on skin are poorly known. OBJECTIVE: The purpose of this study was to model the artificial visible light emitted by electronic devices and assess its effect on normal human fibroblasts. METHODS: The spectral irradiance emitted by electronic devices was optically measured and equipment was developed to accurately reproduce such artificial visible light...
May 5, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29789228/distinct-kinetics-of-two-pathologies-induced-in-mice-by-topical-treatment-with-imiquimod-cream-psoriasis-like-inflammation-and-systemic-autoimmunity
#20
LETTER
Sayo Kataoka, Mayuko Yamamoto, Kentaro Ohko, Kimiko Nakajima, Shigetoshi Sano
No abstract text is available yet for this article.
May 4, 2018: Journal of Dermatological Science
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