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Coronary Artery Disease

Ji Young Park, Byoung Geol Choi, Seung-Woon Rha, Tae Soo Kang
BACKGROUND: Acute myocardial infarction (AMI) is a progressive disease in Korea and active treatment strategies can improve the clinical outcomes. In the CADILLAC trial, anemia on admission was associated strongly with adverse outcomes and increased mortality in AMI. However, it remains controversial whether anemia on admission is an independent poor prognostic factor of long-term clinical outcomes in AMI patients undergoing a percutaneous coronary intervention with a drug-eluting stent in Koreans...
August 1, 2018: Coronary Artery Disease
Krzysztof L Bryniarski, Erika Yamamoto, Tomoyo Sugiyama, Lei Xing, Hang Lee, Ik-Kyung Jang
AIMS: Prevalence of coronary artery disease as well as cardiac mortality varies between Asian and White patients. However, the link between race and plaque characteristics in patients with coronary artery disease remains largely unexplored. Thus, we aimed to investigate the detailed culprit plaque characteristics between East Asian and White patients using optical coherence tomography. PATIENTS AND METHODS: A total of 101 East Asians were matched to 101 White patients...
July 16, 2018: Coronary Artery Disease
Daniel A Jones, Krishnaraj S Rathod, Antonis N Pavlidis, Sean M Gallagher, Zoe Astroulakis, Pitt Lim, Alexander Sirker, Charles J Knight, Miles C Dalby, Iqbal S Malik, Anthony Mathur, Roby Rakhit, Simon Redwood, Philip A MacCarthy, Chris Baker, Ranil Desilva, Carlo Di Mario, Roshan Weerackody, Jonathan Hill, Andrew Wragg, Elliot J Smith
BACKGROUND: Chronic total occlusions (CTO) are commonly encountered in patients undergoing coronary angiography; however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a lack of randomized data. The aim of this study was to analyse the frequency and outcomes of CTO-PCI procedures in a large contemporary cohort of successive patients. PATIENTS AND METHODS: We undertook an observational cohort study of 48 234 patients with stable angina of which 5496 (11...
July 5, 2018: Coronary Artery Disease
Ryota Kakizaki, Yoshiyasu Minami, Takehiro Hashikata, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako
BACKGROUND: The aim of this study was to investigate whether the underlying plaque type affects the neointimal coverage after drug-eluting stent implantation. METHODS: A total of 1793 struts in 22 zotarolimus-eluting stents were assessed using optical coherence tomography imaging within 3 months of implantation. Neointimal coverage was evaluated within 5 mm from each stent edge on cross-sectional optical coherence tomography images at every 1-mm interval. The percentage of struts covered by neointima was compared among the normal segment group, the fibrous plaque group, and the lipid plaque group on the basis of the underlying plaque type...
July 2, 2018: Coronary Artery Disease
Alejandro Gutiérrez-Barrios, Dolores Cañadas-Pruaño, Teresa Bretones-Del Pino, Miguel Alba-Sánchez, Dolores Ruiz-Fernández, Germán Calle-Perez, Antonio Agarrado-Luna, Ricardo Zayas-Rueda, Ernesto Marante-Fuertes, Alberto Giráldez-Valpuesta, Jesús Oneto-Otero, Rafael Vázquez-García
BACKGROUND: Debate still remains on whether the presence of early recruited collateral circulation (ERCC) in the setting of an acute coronary occlusion (ACO) has a prognosis benefit. Some previous reports have shown lower mortality and morbidity rates in well-collateralized patients compared with those with poorly recruited collateral circulation (PCC), but others have not. In the primary angioplasty era, the role of collateral circulation in these studies may have been influenced by the effect of early reperfusion...
June 30, 2018: Coronary Artery Disease
Min Gyu Kang, Yoomee Kang, Hyun Gyung Jang, Kyehwan Kim, Jin-Sin Koh, Jeong Rang Park, Seok-Jae Hwang, Jin-Yong Hwang, Jae Seok Bae, Jong-Hwa Ahn, Jeong Yoon Jang, Yongwhi Park, Young-Hoon Jeong, Choong Hwan Kwak, Hyun Woong Park
BACKGROUND: This study aimed to evaluate whether the coronary artery calcium score (CACS) measured with computed tomography coronary angiography (CTCA) predicts periprocedural myocardial infarction (PMI) in patients undergoing an elective percutaneous coronary intervention (PCI). PATIENTS AND METHODS: A total of 197 patients with stable angina underwent elective PCI after CTCA. We evaluated CACS using CTCA and assessed the clinical risk factors for PMI. PMI was defined as an elevation of troponin I levels exceeding five times the upper limit of normal within 24 h after PCI...
June 29, 2018: Coronary Artery Disease
Hiroki Emori, Takashi Kubo, Takeyoshi Kameyama, Yasushi Ino, Yoshiki Matsuo, Hironori Kitabata, Kosei Terada, Yosuke Katayama, Akira Taruya, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVE: Quantitative flow ratio (QFR) is a novel physiological index of the severity of coronary stenosis. The aim of the present study was to investigate the relationship between QFR and the instantaneous wave-free ratio (iFR). PATIENTS AND METHODS: We analyzed contrast-flow QFR, iFR, and fractional flow reserve (FFR) in 100 coronary arteries with intermediate stenosis. RESULTS: There was a high correlation (r=0.71, P<0.001) and a good agreement (mean difference: -0...
June 29, 2018: Coronary Artery Disease
Matthew W P Jackson, David Austin, Neil Swanson, Paul D Williams, Douglas F Muir, Jim A Hall, Robert A Wright, Andrew G C Sutton, Justin Carter, Mark A de Belder
BACKGROUND: The PRAMI and CvLPRIT trials support preventive percutaneous coronary intervention (PCI) for multivessel coronary disease found during ST-segment elevation myocardial infarction (STEMI). We assess our real-world experience of the management of multivessel disease identified during primary PCI (PPCI) in a large UK regional centre. PATIENTS AND METHODS: All STEMI patients who underwent culprit-only PPCI during the study period (August 2011 to August 2013) were retrospectively assessed for eligibility to each trial...
June 25, 2018: Coronary Artery Disease
Sivabaskari Pasupathy, John F Beltrame
No abstract text is available yet for this article.
September 2018: Coronary Artery Disease
Henrique B Ribeiro
No abstract text is available yet for this article.
September 2018: Coronary Artery Disease
Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Kareem Abdelshafi, Yoonjee Park, Won Young Jang, Kim Woohyeun, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
September 2018: Coronary Artery Disease
Leor Perl, Véronique Peiffer, Audelia E Fuhrer, Fabrizio D'Ascenzo, Jan B Pietzsch
BACKGROUND: Despite advancements in treatment, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in the elderly population. Previous research has highlighted long-standing sex disparities in the care of these patients. However, differences in the patterns of discharge are not well described. One key parameter is the destination of discharge, and in particular - discharge to skilled nursing facilities (SNFs), a factor associated with worse prognosis and greater costs to the healthcare system...
September 2018: Coronary Artery Disease
Hui Liu, Mingjun Zhang, Delong Li, Jingjing Tian, Xuyang Wang, Jinyu Pan, Dian Liu, Xiaowei Li, Fengshuang An
BACKGROUND: The aim of this study is to compare the efficacy and safety of pitavastatin and atorvastatin using data from randomized-controlled trial pooled together by means of a meta-analysis and decide which is better. METHODS: PubMed, CENTRAL, Web of Knowledge, and website were searched for randomized-controlled trials published until October 2016. Eligible studies comparing pitavastatin with atorvastatin head to head and reporting the outcome of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin, and intravascular ultrasound evaluation were enrolled...
September 2018: Coronary Artery Disease
Ji Young Park, Byoung Geol Choi, Seung-Woon Rha, Tae Soo Kang, Cheol Ung Choi, Cheol Woong Yu, Hyeon-Cheol Gwon, In-Ho Chae, Hyo-Soo Kim, Hun Sik Park, Seung-Hwan Lee, Moo-Hyun Kim, Seung-Ho Hur, Yangsoo Jang
BACKGROUND: The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. PATIENTS AND METHODS: Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15%) patients underwent primary PCI because of AMI...
September 2018: Coronary Artery Disease
Yoshitaka Kumada, Hideki Ishii, Toru Aoyama, Daisuke Kamoi, Takashi Sakakibara, Norio Umemoto, Ryuta Ito, Hiroshi Takahashi, Toyoaki Murohara
BACKGROUND: It remains controversial whether coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) should be optimized to treat coronary artery disease in patients on chronic hemodialysis (HD). Recently, further refinement of drug-eluting stents, such as the everolimus-eluting stent (EES), has led to marked development in this field. We compared long-term clinical outcomes after CABG versus PCI with EES implantation in patients on chronic HD. PATIENTS AND METHODS: We compared 138 patients undergoing CABG and 187 patients treated with EES implantation...
September 2018: Coronary Artery Disease
Maayan Konigstein, Ori Ben-Yehuda
No abstract text is available yet for this article.
September 2018: Coronary Artery Disease
Andrew T Yan, Matthew T Roe, Megan Neely, Derek D Cyr, Harvey White, Keith A A Fox, Dorairaj Prabhakaran, Paul W Armstrong, Erik M Ohman, Shaun G Goodman
BACKGROUND: In the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial of patients with non-ST-segment elevation acute coronary syndrome managed medically without revascularization, treated with prasugrel versus clopidogrel for less than or equal to 30 months after index acute coronary syndrome, post-hoc analyses showed a divergence of treatment effect in favor of prasugrel after 12 months. Potential influential factors, including a potential late treatment effect after early study drug discontinuation in the intention-to-treat analysis, have not been explored...
September 2018: Coronary Artery Disease
Stephen Hamshere, Alex Byrne, Oliver Guttmann, Paul Rees, Christos Bourantas, Roshan Weerakody, Andrew Wragg, Charles Knight, Anthony Mathur, Daniel A Jones
OBJECTIVES: The introduction of the bioresorbable vascular scaffold (BVS) has led to new avenues of coronary intervention; however, there have been concerns raised regarding the mechanical properties of BVS and the resulting in-stent thrombosis. We aim to assess whether intracoronary imaging improves outcome in patients following BVS implantation. PATIENTS AND METHODS: All patients undergoing percutaneous coronary intervention using BVS at a single centre between June 2013 and June 2016 were included in this study (n=79)...
September 2018: Coronary Artery Disease
Rosa Alba Abellas-Sequeiros, Javier Benezet, Antonio Agarrado Luna, Jesús Oneto Otero, Jean-Pierre Déry, Tomas Cieza, Robert DeLarochellière, Lluis Duocastella, Alex Gomez, Maria Molina, Lluis Asmarats, Emilie Pelletier-Beaumont, Rishi Puri, Josep Rodés-Cabau
BACKGROUND: Paclitaxel-coated balloon (PCB) coronary angioplasty is an alternative treatment for de-novo coronary lesions in small vessels. This study with the new Essential PCB aimed to evaluate early and mid-term clinical outcomes following angioplasty with the Essential PCB in the treatment of de-novo lesions in small vessels. PATIENTS AND METHODS: We included all patients who underwent PCB angioplasty for treating de-novo coronary lesions in small vessels (reference diameter <2...
September 2018: Coronary Artery Disease
Cristina Aurigemma, Francesco Burzotta, Filippo Crea, Carlo Trani
No abstract text is available yet for this article.
September 2018: Coronary Artery Disease
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