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Coronary Artery Disease

A Anil Timur, John Barnard, Gurunathan Murugesan, Sanjay Gandhi, Deepak L Bhatt, Kandice Kottke-Marchant
BACKGROUND: ABO blood groups have been associated with venous thromboembolism and arterial thrombosis. Although platelets play key roles in thrombogenesis, the relation between ABO groups and platelets is not well known and was investigated in this study. PATIENTS AND METHODS: ABO blood type information was retrospectively obtained for 206 patients who underwent percutaneous coronary intervention and received dual antiplatelet therapy with aspirin and clopidogrel...
November 6, 2018: Coronary Artery Disease
Nadav Teich, Dmitry Pevni, Rephael Mohr, Nahum Nesher, Amir Kramer, Yosef Paz, Yanai Ben-Gal
BACKGROUND: The use of two bilateral internal thoracic artery grafting (BITA) was shown to lead to survival benefit. However, operators are reluctant to use BITA with peripheral vascular disease (PVD) because of concerns of increased rates of sternal wound infection and lack of studies supporting survival benefit compared with single internal thoracic artery (SITA) grafting. The aim of this study is to compare outcome BITA grafting versus of SITA and vein grafts in PVD patients. PATIENTS AND METHODS: Six hundred and twenty-one PVD patients who underwent BITA between 1996 and 2011 were compared with 372 patients who underwent SITA...
November 6, 2018: Coronary Artery Disease
Rocco Vergallo, Michail I Papafaklis, Domenico D'Amario, Lampros K Michalis, Filippo Crea, Italo Porto
No abstract text is available yet for this article.
November 6, 2018: Coronary Artery Disease
Dongjie Liang, Xiaodong Zhou, Xia Hong, Xiafei Feng, Peiren Shan, Qiangli Xie, Tiancheng Xu, Mengxing Cai, Jian Zhou, Songjie Wang, Weijian Huang
OBJECTIVE: Hyperlactatemia at admission is associated with poor outcome in critically ill patients. However, data on the prognostic value of blood lactate level in patients with acute coronary syndrome (ACS) are limited. The present study assessed the prognostic effect of admission lactate level in a large population of patients with ACS. MATERIALS AND METHODS: This was a retrospective observational study including patients with ACS who were admitted to the Coronary Care Unit of the First Affiliated Hospital of Wenzhou Medical University between 2014 and 2017...
November 5, 2018: Coronary Artery Disease
Jaume Figueras, Jordi Bañeras, Domenico Gruosso, Jose R Palomares, José A Barrabés, David Garcia-Dorado
BACKGROUND: The relationship between admission left ventricular (LV) volumes, regional contractility and persistent ST elevation in first anterior ST elevation myocardial infarction (STEMI) with evolution of LV volumes at 12 month remains inconclusive. Thus possible differences among patients with reverse dilatation (RD), stationary dilatation (SD) or progressive dilatation (PD) LV dilatation at 12 month based on left ventricle end-systolic volume (LVESV) index changes were investigated...
October 31, 2018: Coronary Artery Disease
Marcos Garcia-Guimaraes, Paula Antuña, Ramon Maruri-Sanchez, Alberto Vera, Javier Cuesta, Teresa Bastante, Fernando Rivero, Fernando Alfonso
BACKGROUND: Neoatherosclerosis has emerged as a major cause of in-stent restenosis (ISR). Although this entity has been described as a unique process, optical coherence tomography (OCT) enables depiction of distinct morphologic patterns, including the presence of calcified sheets within the stent. We sought to assess prevalence, predictors, and implications of calcified neoatherosclerosis (cNA) as the cause of ISR. METHODS AND RESULTS: From January 2014 to August 2016, 75 consecutive patients with 81 ISR lesions with a clinical indication for revascularization were evaluated by OCT before reintervention...
October 30, 2018: Coronary Artery Disease
Se Hun Kang, Jung-Min Ahn, Jung-Bok Lee, Cheol Hyun Lee, Do-Yoon Kang, Pil Hyung Lee, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
OBJECTIVES: Coronary bifurcations are common in daily practice of percutaneous coronary intervention and remain one of the most challenging lesions, but it is still unknown how characteristics, treatment strategy, and outcomes have changed over the last decade of drug-eluting stents (DES) era. We evaluated characteristics of treatment pattern and outcomes for patients with bifurcation disease over time in real-world clinical practice. PATIENTS AND METHODS: A total of 7282 patients with coronary bifurcation lesions were pooled from the Interventional Cardiology Research Incorporation Society-Drug-Eluting Stents registry and the Interventional Research Incorporation Society-Left MAIN registry...
October 26, 2018: Coronary Artery Disease
Omar Jawaid, Maggie Stanislawski, Rory Bricker, Mary E Plomondon, Gary K Grunwald, Javier A Valle, Ehrin J Armstrong, Stephen W Waldo
BACKGROUND: Intra-aortic balloon pumps (IABP) support nonemergent and emergent percutaneous coronary intervention (PCI). Recent studies have not showed a routine benefit to this practice. We sought to evaluate the temporal trends in balloon pump utilization and site-level variation within a large integrated healthcare system. PATIENTS AND METHODS: We identified all patients that underwent PCI in the Veterans Affairs Healthcare System between 1 January 2008 and 31 December 2015...
October 24, 2018: Coronary Artery Disease
Guilherme Pinheiro Machado, Gustavo N Araujo, Christian K Carpes, Mateus C Lech, Stefani Mariani, Felipe H Valle, Luiz C C Bergoli, Rodrigo V Wainstein, Marco V Wainstein
BACKGROUND: Elevated neutrophil-to-lymphocyte ratio (NLR) is an indirect marker of inflammation, and is associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to investigate the usefulness of NLR to predict procedural adverse events is patients who underwent primary percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Consecutive patients with STEMI who underwent primary PCI were divided into low and high NLR, whereas high was defined as an NLR value above 75° percentile (≥9...
October 16, 2018: Coronary Artery Disease
Ronny Maor, Jaskanwal D S Sara, Amanda A Wanous, Elad Maor, Sandhya Pruthi, Amir Lerman, Nicole P Sandhu
PURPOSE: Data on long-term cardiovascular effects of aromatase inhibitors (AIs) are limited and conflicting. We sought to evaluate the effect of AIs on peripheral endothelial function in patients with breast cancer. PATIENTS AND METHODS: This is an observational, prospective study of postmenopausal women with breast cancer who were enrolled at the initiation of cancer treatment. All participants underwent baseline and 6-12 months of follow-up, with peripheral endothelial function testing to measure reactive hyperemia index (RHI)...
December 2018: Coronary Artery Disease
David E Kandzari, J Aaron Grantham, Dimitrios Karmpaliotis, William Lombardi, Jeffrey W Moses, William Nicholson, Stephen Cook, Ashish Pershad, Jeffrey J Popma
BACKGROUND: Limited study has detailed the procedural outcomes and utilization of contemporary coronary guidewires and microcatheters designed for chronic total occlusion (CTO) percutaneous revascularization and with application of modern techniques. PATIENTS AND METHODS: A prospective, multicenter, single-arm trial was conducted to evaluate procedural and in-hospital outcomes among 163 patients undergoing attempted CTO revascularization with specialized guidewires and microcatheters...
December 2018: Coronary Artery Disease
Yoav Preisler, Tomer Ziv-Baran, Ehud Chorin, Gilad Margolis, Shafik Khoury, Yacov Shacham
BACKGROUND: A positive family history (FHx+) of coronary artery disease (CAD) is a well-known risk factor for the development of coronary pathology in first-degree relatives. We sought to evaluate the association between FHx+ of CAD and clinical outcomes in patients presenting with a first ST-elevation myocardial infarction (STEMI). PATIENTS AND METHODS: A historical cohort study of all patients with a first STEMI, who were admitted to cardiac ICU between 2007 and 2016, was carried out...
December 2018: Coronary Artery Disease
Takashi Yokota, Takumi Higuma, Tomohide Endo, Fumie Nishizaki, Kenji Hanada, Hiroaki Yokoyama, Masahiro Yamada, Ken Okumura, Hirofumi Tomita
BACKGROUND: Prasugrel was shown to inhibit platelet activity more rapidly and consistently than clopidogrel. We compared the effects of prasugrel and clopidogrel on residual thrombus burden assessed by optical coherence tomography after stent implantation in patients with ST-segment elevation myocardial infarction (STEMI). PATIENTS AND METHODS: A total of 76 patients with STEMI undergoing percutaneous coronary intervention (PCI) within 12 h after the onset were retrospectively enrolled...
December 2018: Coronary Artery Disease
Francesco Fracassi, Vincenzo Vetrugno, Alessandro Mandurino-Mirizzi, Nicola Cosentino, Serena Panicale, Patrizia Caprari, Giampaolo Niccoli, Filippo Crea
BACKGROUND: Abnormal blood viscosity favors atherosclerosis owing to endothelial dysfunction and changes in shear stress. Its effect on coronary microvasculature during percutaneous coronary intervention (PCI) is still unknown. We aimed to investigate the role of hemorheological parameters in the incidence of microvascular obstruction (MVO) and the periprocedural necrosis after primary or elective PCI, and secondarily, we evaluated their prognostic significance. MATERIALS AND METHODS: We enrolled 25 patients with ST-elevation myocardial infarction (STEMI), 30 patients with non-ST-elevation myocardial infarction (NSTEMI), and 30 patients with stable angina (SA) undergoing PCI...
December 2018: Coronary Artery Disease
Jörg Schröder, Felix Vogt, Mathias Burgmaier, Sebastian Reith, Mohammad Almalla
BACKGROUND: Treatment of in-stent restenosis (ISR) is still a clinical challenge in interventional cardiology. Paclitaxel-coated balloons (PCBs) are an attractive therapeutic option for ISR. There are several different types of PCBs available for percutaneous coronary intervention, but to date, comparative data between different types of PCBs for the treatment of ISR are scarce. PATIENTS AND METHODS: This single centre, nonrandomized, retrospective study under real-world condition included 194 patients with 194 ISR treated by repeat percutaneous coronary intervention with PCBs...
December 2018: Coronary Artery Disease
Wen-Feng Li, Yu-Qing Huang, Ying-Qing Feng
BACKGROUND: Oxygen therapy is widely used for patients with acute myocardial infarction (AMI). However, there is uncertainty about its safety and benefits. The aim of this study is to perform a systematic review and meta-analysis to assess the effectiveness and safety of oxygen therapy for patients with AMI. MATERIALS AND METHODS: We searched MEDLINE, CINAHL, EMBASE, Cochrane Central Register of Controlled Trials from 1 January 1967, through 31 December 2017. We included randomized controlled clinical trials that used oxygen therapy for patients with suspected or confirmed AMI less than 24 h of symptoms onset...
December 2018: Coronary Artery Disease
Carmen Dejuán-Bitriá, Miriam Estébanez, Carmen López-Galán, Andrea Montes-Torres, David Martí
No abstract text is available yet for this article.
December 2018: Coronary Artery Disease
Tomasz S Podolecki, Radoslaw K Lenarczyk, Jacek P Kowalczyk, Ewa K Jedrzejczyk-Patej, Piotr K Chodor, Michal H Mazurek, Pawel J Francuz, Witold A Streb, Katarzyna A Mitrega, Zbigniew F Kalarus
OBJECTIVES: The primary aim of the study was to evaluate risk factors for ventricular fibrillation/sustained ventricular tachycardia (VF/VT) and to develop the risk score for prediction of VF/VT in patients with ST-segment elevation myocardial infarction (STEMI) treated invasively. The secondary aim was to assess the effect of VF/VT on mortality depending on timing of arrhythmia. PATIENTS AND METHODS: We analyzed 4363 consecutive patients with STEMI treated invasively...
December 2018: Coronary Artery Disease
Doosup Shin, Bibhu D Mohanty, Eun Sun Lee
BACKGROUND: For patients who have an indication for anticoagulation, it is controversial whether dual therapy with an oral anticoagulant and single antiplatelet agent can be used after percutaneous coronary intervention (PCI) or acute coronary syndrome (ACS) instead of triple therapy with an oral anticoagulant and dual antiplatelet therapy. PARTICIPANTS AND METHODS: Twelve observational studies and four clinical trials were identified from three electronic databases from their inception to December, 2017...
December 2018: Coronary Artery Disease
Ji Young Park, Byoung Geol Choi, Seung-Woon Rha, Tae Soo Kang
BACKGROUND: Acute myocardial infarction (AMI) is a progressive disease in Korea and active treatment strategies can improve the clinical outcomes. In the CADILLAC trial, anemia on admission was associated strongly with adverse outcomes and increased mortality in AMI. However, it remains controversial whether anemia on admission is an independent poor prognostic factor of long-term clinical outcomes in AMI patients undergoing a percutaneous coronary intervention with a drug-eluting stent in Koreans...
December 2018: Coronary Artery Disease
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