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Coronary Artery Disease

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https://www.readbyqxmd.com/read/29351093/coronary-intervention-for-chronic-total-occlusions-what-should-the-guidelines-say
#1
Gabby Elbaz-Greener, Bradley H Strauss
No abstract text is available yet for this article.
January 18, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29346127/rivaroxaban-with-or-without-aspirin-for-prevention-of-cardiovascular-disease
#2
Paul C Kruger, John W Eikelboom, Salim Yusuf
No abstract text is available yet for this article.
January 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29346126/complete-revascularization-for-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-artery-disease-a-meta-analysis-of-randomized-trials
#3
Gani Bajraktari, Haki Jashari, Pranvera Ibrahimi, Fernando Alfonso, Fisnik Jashari, Gjin Ndrepepa, Shpend Elezi, Michael Y Henein
INTRODUCTION: Despite the recent findings in randomized clinical trials (RCTs) with limited sample sizes and the updates in clinical guidelines, the current available data for the complete revascularization (CR) in hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) at the time of primary percutaneous coronary intervention (PCI) are still contradictory. AIM: The aim of this meta-analysis of the existing RCTs was to assess the efficacy of the CR versus revascularization of infarct-related artery (IRA) only during primary PCI in patients with STEMI and multivessel disease (MVD)...
January 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29334505/the-association-of-chronic-air-pollutants-with-coronary-artery-spasm-vasospastic-angina-and-endothelial-dysfunction
#4
Byoung Geol Choi, Jiwon Lee, Suhng Wook Kim, Min Woo Lee, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Ahmed Mashaly, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha
BACKGROUND: We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. PATIENTS AND METHODS: A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www...
January 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29334504/bradykinin-receptors-gene-expression-in-white-adipose-tissue-in-nondiabetic-patients-with-coronary-artery-disease
#5
Maria E Marketou, George Kochiadakis, Joanna Kontaraki, Evangelos Zacharis, Emmanouel Kanoupakis, Emmanouel Kallergis, Hercules Mavrakis, Panagiotis Tsiverdis, Dimitris Lempidakis, John Konstantinou, Konstantinos Fragkiadakis, Gregory Chlouverakis, Panos Vardas, Fragiskos Parthenakis
OBJECTIVES: Adipose tissue plays a key role in cardiovascular physiology. Kinin receptors are important determinant of the effect of adiposity on endothelial function and cardiovascular function. We examined the gene expression levels of kinin receptors in the subcutaneous white adipose tissue (sWAT) of nondiabetic patients with and without coronary artery disease (CAD). PATIENTS AND METHODS: We evaluated 21 patients with CAD (13 men, age: 68±8 years) and 23 patients without CAD (15 men, age: 66±5 years) who underwent catheterization through the femoral route...
January 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29315085/biopsy-confirmed-endothelial-cell-activation-in-patients-with-coronary-microvascular-dysfunction
#6
Hannes Lindemann, Ivana Petrovic, Stephan Hill, Anastasios Athanasiadis, Heiko Mahrholdt, Tim Schäufele, Karin Klingel, Udo Sechtem, Peter Ong
BACKGROUND: Patients with angina yet having unobstructed coronaries are found in ∼50% of cases undergoing invasive angiography. Coronary spasm and microvascular dysfunction can be responsible for the clinical presentation in ∼60% of cases. However, little is known about structural changes in the myocardium. The aim of this study was to describe findings in endomyocardial biopsies of symptomatic patients with unobstructed coronaries. PATIENTS AND METHODS: We retrospectively analyzed a cohort of 1416 consecutive patients who underwent endomyocardial biopsy sampling and coronary angiography between 2002 and 2016 for various clinical indications...
January 8, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29309286/the-paradox-of-clopidogrel-use-in-patients-with-acute-coronary-syndromes-and-diabetes-insight-from-the-diabetes-and-acute-coronary-syndrome-registry
#7
Marco Ferlini, Giuseppe Musumeci, Niccolò Grieco, Roberta Rossini, Stefano De Servi, Antonio Mafrici, Carlo Sponzilli, Andrea Demarchi, Emilio M Assanelli, Paola Camisasca, Giuliano Chizzola, Elena Corrada, Andrea Farina, Claudio Pedrinazzi, Corrado Lettieri, Luigi Oltrona Visconti
BACKGROUND: Patients with diabetes mellitus (DM) and acute coronary syndromes have a greater level of platelet aggregation and a poor response to oral antiplatelet drugs. Clopidogrel is still widely used in clinical practice, despite the current evidence favoring ticagrelor and prasugrel. AIM: The aim of this study was to investigate the determinants of clopidogrel use in the population of the multicenter prospective 'Acute Coronary Syndrome and Diabetes Registry' carried out during a 9-week period between March and May 2015 at 29 Hospitals...
January 5, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29280914/anemia-and-coronary-artery-disease-pathophysiology-prognosis-and-treatment
#8
Jennifer A Rymer, Sunil V Rao
The mechanisms, pathophysiology, and treatment of anemia in coronary artery disease (CAD) are complex. The hemodynamic changes found in the acute anemic state may contribute to progressive arterial wall and left ventricular hypertrophy if the anemic state persists chronically. We will examine the evidence for anemia as an independent risk factor for CAD events and cardiovascular mortality after percutaneous coronary intervention. We will also investigate the thresholds for appropriate blood transfusion in patients with CAD, as well as the cardiovascular outcomes associated with the utilization of a liberal versus conservative blood transfusion strategy...
December 26, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29261521/quantitative-analysis-of-intraventricular-flow-energetics-and-vortex-in-ischaemic-hearts
#9
Bee Ting Chan, Hak Koon Yeoh, Yih Miin Liew, Socrates Dokos, Amr Al Abed, Kok Han Chee, Yang F Abdul Aziz, Ganiga Srinivasaiah Sridhar, Karuthan Chinna, Einly Lim
OBJECTIVE: This study investigated the intraventricular flow dynamics in ischaemic heart disease patients. PATIENTS AND METHODS: Fourteen patients with normal ejection fraction and 16 patients with reduced ejection fraction were compared with 20 healthy individuals. Phase-contrast MRI was used to assess intraventricular flow variables and speckle-tracking echocardiography to assess myocardial strain and left ventricular (LV) dyssynchrony. Infarct size was acquired using delayed-enhancement MRI...
December 19, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29215472/intraplaque-hemorrhage-in-a-patient-with-acute-coronary-syndrome-insights-from-multimodality-imaging
#10
Nozomu Kanehama, Shigeki Kimura, Kenji Yoshioka, Ryota Iwatsuka, Akihiko Matsumura
No abstract text is available yet for this article.
December 5, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29215471/long-term-outcomes-of-a-recanalized-thrombus-treated-with-a-paclitaxel-coated-balloon-insights-from-optical-coherence-tomography
#11
Yusuke Watanabe, Yusuke Fujino, Hisaaki Ishiguro, Sunao Nakamura
No abstract text is available yet for this article.
December 5, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29215470/invasive-assessment-of-microvascular-function-in-patients-with-valvular-heart-disease
#12
Takeshi Nishi, Hideki Kitahara, Saito Yuichi, Tomoko Nishi, Takashi Nakayama, Yoshihide Fujimoto, Goro Matsumiya, Yoshio Kobayashi
BACKGROUND: The aim of this study was to investigate microvascular function in patients with valvular heart disease (VHD), which causes chronic left ventricular volume and/or pressure overload, therefore change in coronary microvascular hemodynamics. PATIENTS AND METHODS: We prospectively enrolled 30 patients with VHD considered for surgery (10 aortic stenosis, 12 aortic regurgitation, and eight mitral regurgitation) and 30 controls. Intracoronary physiological assessments were performed in the unobstructed left anterior descending artery using a pressure-temperature sensor guidewire at rest and hyperemia...
December 5, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29215469/multimodality-coronary-imaging-to-predict-periprocedural-myocardial-necrosis-after-an-elective-percutaneous-coronary-intervention
#13
Masahiro Hoshino, Taishi Yonetsu, Tadashi Murai, Yoshihisa Kanaji, Eisuke Usui, Masao Yamaguchi, Masahiro Hada, Rikuta Hamaya, Yoshinori Kanno, Tetsumin Lee, Tsunekazu Kakuta
BACKGROUND: Although multiple imaging modalities have been tested to predict periprocedural myocardial necrosis (PMN), the superior predictive efficacy of these imaging findings has not been established fully. We sought to evaluate which findings of the coronary imaging tools would best provide predictive efficacy of PMN among optical coherence tomography (OCT), intravascular ultrasound (IVUS), and coronary computed tomography (CCT) angiography. PATIENTS AND METHODS: A total of 130 patients with stable angina pectoris who underwent OCT, IVUS, and CCT examinations for a single de-novo preprocedural lesion were investigated...
December 5, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29194090/the-association-between-uric-acid-levels-and-different-clinical-manifestations-of-coronary-artery-disease
#14
Trine R Larsen, Oke Gerke, Axel C P Diederichsen, Jess Lambrechtsen, Flemming H Steffensen, Niels P Sand, Lotte Saaby, Steen Antonsen, Hans Mickley
AIMS: Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). PATIENTS AND METHODS: The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan...
November 29, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29176378/clinical-characteristics-and-outcomes-of-patients-with-coronary-artery-spasm-who-initially-presented-with-acute-myocardial-infarction
#15
Ji Bak Kim, Byoung Geol Choi, Seung-Woon Rha, Hong Seog Seo, Se Yeon Choi, Jae Kyeong Byun, Jin Oh Na, Cheol Ung Choi, Eung Ju Kim, Chang Gyu Park, Dong Joo Oh
BACKGROUND: The long-term clinical outcomes of coronary artery spasm (CAS) patients presented with acute myocardial infarction (AMI) compared to those who did not present with AMI has rarely been investigated. METHODS: From November 2004 to May 2014, a total of 3360 patients who were confirmed as CAS by the acetylcholine (Ach) provocation test and without significant coronary lesion were retrospectively analyzed. AMI was an initial presentation in 34 patients [CAS-myocardial infarction (MI) group], and not in other 3326 patients (CAS group)...
November 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29140809/stem-cell-therapy-for-acute-myocardial-infarction-on-the-horizon-or-still-a-dream
#16
Kenneth M Fish, Kiyotake Ishikawa, Roger J Hajjar
No abstract text is available yet for this article.
November 14, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29140808/randomized-trial-evaluating-the-effect-of-aged-garlic-extract-with-supplements-versus-placebo-on-adipose-tissue-surrogates-for-coronary-atherosclerosis-progression
#17
Irfan Zeb, Naser Ahmadi, Ferdinand Flores, Matthew J Budoff
AIMS: Increased epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), periaortic adipose tissue (PaAT), and subcutaneous adipose tissue (SAT) are mediators of metabolic risk, and are associated with the severity of coronary artery calcium (CAC). Aged garlic extract (AGE) has been shown to reduce the progression of coronary atherosclerosis. This study evaluates the effect of AGE with supplements (AGE+S) on EAT, PAT, SAT, and PaAT. METHODS: Sixty asymptomatic participants participated in a randomized trial evaluating the effect of AGE+S versus placebo on coronary atherosclerosis progression, and underwent CAC at baseline and after 12 months of treatment...
November 14, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29135483/coronary-periarteritis-associated-with-multivessel-coronary-artery-disease
#18
Kazushi Sakane, Ryoto Hourai, Masahiro Daimon, Koichi Sohmiya, Hiroko Kuwabara, Takahiro Katsumata, Michishige Ozeki, Yoshinobu Hirose, Nobukazu Ishizaka
No abstract text is available yet for this article.
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#19
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29120880/culprit-versus-multivessel-coronary-intervention-in-st-segment-elevation-myocardial-infarction-a-meta-analysis-of-randomized-trials
#20
Satyanarayana R Vaidya, Arman Qamar, Sameer Arora, Santhosh R Devarapally, Ashok Kondur, Prashant Kaul
BACKGROUND: The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite evidence supporting complete revascularization in STEMI, its benefit on mortality rates is uncertain. METHODS: We searched all available databases for randomized controlled trials comparing complete multivessel percutaneous coronary intervention (CMV PCI) with infarct-artery-only revascularization in patients with STEMI...
November 8, 2017: Coronary Artery Disease
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