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Coronary Artery Disease

Sandeep Hedgire, Benjamin Pulli, Manuella Lahoud-Rahme, Rebecca S Beroukhim, Ana M Rosales, Brian Ghoshhajra
No abstract text is available yet for this article.
October 14, 2016: Coronary Artery Disease
Nermina Buljubasic, K Martijn Akkerhuis, Jin M Cheng, Rohit M Oemrawsingh, Hector M Garcia-Garcia, Sanneke P M de Boer, Evelyn Regar, Robert-Jan M van Geuns, Patrick W J C Serruys, Eric Boersma, Isabella Kardys
OBJECTIVE: The aim of this study was to provide additional insight into the role of fibrinogen in coronary artery disease by investigating the associations between plasma fibrinogen with both degree and composition of coronary atherosclerosis as determined by virtual histology-intravascular ultrasound. PATIENTS AND METHODS: In 581 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina pectoris, preprocedural blood samples were drawn for fibrinogen, C-reactive protein (CRP), interleukin-6, and plasminogen activator inhibitor-1 measurements, and virtual histology-intravascular ultrasound of a nonculprit coronary artery was performed...
October 14, 2016: Coronary Artery Disease
Matthew J Budoff, Nove Kalia, Jason Cole, Rine Nakanishi, Negin Nezarat, Joseph L Thomas
BACKGROUND: Although several studies have shown promise for noninvasive angiography by coronary computed tomographic angiography (CCTA), few prospective multicenter trials have been conducted. This study evaluated the diagnostic accuracy of Visipaque enhanced CCTA to detect obstructive coronary stenosis compared with quantitative coronary angiography (QCA). PATIENTS AND METHODS: Three sites prospectively enrolled 77 patients (58.1% men, 54 years) with chest pain referred for invasive coronary angiography (ICA)...
October 14, 2016: Coronary Artery Disease
James Sapontis, Steven P Marso, David J Cohen, William Lombardi, Dimitri Karmpaliotis, Jeffrey Moses, William J Nicholson, Ashish Pershad, R Michael Wyman, Anthony Spaedy, Stephen Cook, Parag Doshi, Robert Federici, Craig R Thompson, Karen Nugent, Kensey Gosch, John A Spertus, J Aaron Grantham
BACKGROUND: Patients with chronic total occlusions of a coronary artery represent a complex, yet common, clinical conundrum among patients with ischemic heart disease. Chronic total occlusion angioplasty is increasingly being used as a treatment for these complex lesions. There is a compelling need to better quantify the safety, efficacy, benefits, and costs of the procedure. METHODS: To address these gaps in knowledge, we designed the Outcomes, Patient Health Status, and Efficiency IN Chronic Total Occlusion Hybrid Procedures (OPEN CTO) study, an investigator-initiated multicenter, single-arm registry including 12 centers with a planned enrollment of 1000 patients...
October 13, 2016: Coronary Artery Disease
John J P Kastelein, Dean J Kereiakes, Christopher P Cannon, Harold E Bays, Pascal Minini, L Veronica Lee, Jaman Maroni, Michel Farnier
OBJECTIVES: The objective of this study is to report the dose response in ODYSSEY phase 3 clinical trials of proprotein convertase subtilisin kexin type 9 inhibition with alirocumab in patients not at prespecified lipid goals who received a per-protocol dose increase from 75 every 2 weeks (Q2W) to 150 mg Q2W. METHODS: Patients (n=2181) receiving statins were enrolled in six phase 3 randomized, double-blind, double-dummy trials (24-104 weeks): alirocumab versus placebo or ezetimibe 10 mg/day...
October 12, 2016: Coronary Artery Disease
Takashi Owada, Hiroyuki Yamauchi, Shu-Ichi Saitoh, Shunsuke Miura, Hirofumi Machii, Yasuchika Takeishi
BACKGROUND: Senescence is a major factor that increases oxidative stress in mitochondria, which contributes toward the pathogenesis of heart disease. However, the effect of antioxidant therapy on cardiac mitochondria in aged-cardiac performance remains elusive. OBJECTIVES: We postulated that the mitochondrial targeting of superoxide scavenging would have benefits in the aged heart. METHODS AND RESULTS: Generation of superoxide in the mitochondria and nicotinamide adenine dinucleotide phosphate oxidase activity increased in the heart of old mice compared with that in young mice...
October 12, 2016: Coronary Artery Disease
Qianqian Chen, Xingchen Shang, Meng Yuan, Lining Liang, Xia Zhong
OBJECTIVE: An association between coronary artery disease (CAD) and serum omentin-1 was recently identified. The aim of the present study was to investigate the effect of atorvastatin on serum levels of omentin-1 in patients with CAD. METHODS: One-hundred and ninety-eight patients with CAD were divided into two groups: those with acute coronary syndrome (ACS) and those with stable angina pectoris (SAP). All patients were randomized to receive atorvastatin therapy at a dose of either 20 or 40 mg/day for 12 weeks...
October 4, 2016: Coronary Artery Disease
Amin Daoulah, Mohamed N Alama, Osama E Elkhateeb, Mushabab Al-Murayeh, Salem Al-Kaabi, Salem M Al-Faifi, Hind M Alosaimi, Amir Lotfi, Khalid S Asiri, Ahmed M Elimam, Ayman S Abougalambo, Waheed Murad, Mamdouh M Haddara, Ciaran M Dixon, Alawi A Alsheikh-Ali
OBJECTIVES: The aim of this study was to assess the association of widowhood with the severity and extent of coronary artery disease (CAD), and whether it is modified by sex or socioeconomic status. PATIENTS AND METHODS: A total of 1068 patients undergoing coronary angiography at five centers in Saudi Arabia and the United Arab Emirates were included in the study. CAD was defined as more than 70% lumen stenosis in a major epicardial vessel or more than 50% in the left main coronary artery...
October 4, 2016: Coronary Artery Disease
Domenico D'Amario, Rocco Vergallo, Carlo Trani, Filippo Crea, Italo Porto
No abstract text is available yet for this article.
September 19, 2016: Coronary Artery Disease
Uri Landes, Ran Kornowski, Tamir Bental, Abid Assali, Hana Vaknin-Assa, Eli Lev, Zaza Iakobishvili
BACKGROUND: Cancer patients are mostly excluded from percutaneous coronary intervention (PCI) clinical trials and oncologic history is lacking from most PCI registries. Thus, little is known about the clinical outcomes following PCI among cancer survivors. Our aim was to examine the prevalence and long-term outcome of cancer survivors among a large PCI patient cohort. METHODS: We retrospectively integrated and analyzed cardiovascular and oncologic data of 12 785 consecutive patients who underwent PCI between April 2004 and October 2014...
September 12, 2016: Coronary Artery Disease
Takao Konishi, Daisuke Hotta, Naohiro Funayama, Tadashi Yamamoto, Hiroshi Nishihara, Shinya Tanaka
No abstract text is available yet for this article.
September 8, 2016: Coronary Artery Disease
Yuhei Kobayashi, Hiroyuki Okura, Yoji Neishi, Tomitaka Higa, Yukari Kobayashi, Shiro Uemura, Kiyoshi Yoshida
BACKGROUND: The induction of hyperemia is of importance to precisely assess the functional significance of coronary artery lesions with fractional flow reserve (FFR). Adenosine or ATP alone is used widely in this setting; however, little is known about the additive value of nicorandil, which acts as a nitrate and a K-ATP channel opener, to induce further hyperemia. PATIENTS AND METHODS: A total of 183 intermediate native coronary artery lesions from 112 patients were prospectively enrolled into this study...
September 8, 2016: Coronary Artery Disease
Sion K Roy, Michelle M Estrella, Annie T Darilay, Matthew J Budoff, Lisa P Jacobson, Mallory D Witt, Lawrence A Kingsley, Wendy S Post, Frank J Palella
BACKGROUND: Decreased kidney function and greater albuminuria are associated with increased incidence and extent of coronary artery calcium (CAC). We investigated whether the associations between kidney function and urine protein-to-creatinine ratio (UPCR) with CAC differ by HIV serostatus. METHODS: Using data from the Multicenter AIDS Cohort Study, a prospective multicenter US study of men who have sex with men, we carried out a cross-sectional study comprised of 592 HIV-infected (HIV+) and 378 uninfected (HIV-) men who underwent noncontrast computed tomography to measure CAC...
September 8, 2016: Coronary Artery Disease
Lei Song, Gary S Mintz, Tadayuki Kadohira, Khady N Fall, David A Brogno, Akiko Maehara
No abstract text is available yet for this article.
September 7, 2016: Coronary Artery Disease
Mustafa A Tatlisu, Adnan Kaya, Muhammed Keskin, Osman Uzman, Edibe B Borklu, Goksel Cinier, Mert I Hayiroglu, Kiymet Tatlisu, Mehmet Eren
BACKGROUND: The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS: This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with STEMI treated with primary percutaneous coronary intervention. The following formula was used to measure the plasma osmolality at admission: osmolality=1...
September 7, 2016: Coronary Artery Disease
Na Zhao, Lan Mi, Yaping Zhang, Na Li, Jiaojiao Xu, Dongyu Xia, Junkui Wang, Yue Wu, Xiaojun Liu
OBJECTIVE: Neutrophils enhancing atherosclerotic plaque instability have been observed in patients with acute coronary syndrome (ACS). Generally, activation of neutrophils in lesions depends on the interaction of Fcγ receptors (FcγRs) with immunoglobulin G antibodies in immune complexes. However, altered FcγR expression on neutrophils of patients with ACS is unknown. We aimed to evaluate changes in FcγR expression on neutrophils of patients with ACS. METHODS: We enrolled 106 patients who were divided into four groups: acute myocardial infarction (AMI), unstable angina (UA), stable angina, and normal coronary arteries...
September 3, 2016: Coronary Artery Disease
Zulong Xie, Jingbo Hou, Huai Yu, Haibo Jia, Hongwei Du, Hang Lee, Bo Yu, Jinwei Tian, Ik-Kyung Jang
OBJECTIVE: Some plaques grow slowly in a linear manner, whereas others undergo a rapid phasic progression. However, the detailed in-vivo relationship between plaque characteristics and plaque progression pattern has not been reported. The current study aimed to investigate the plaque progression patterns with serial intravascular ultrasound (IVUS) examinations, and to correlate baseline plaque characteristics assessed by optical coherence tomography and IVUS with plaque progression patterns...
August 30, 2016: Coronary Artery Disease
Cátia Costa, Pedro de Araújo Gonçalves, António Ferreira, Maria L Pitta, Hélder Dores, Nuno Cardim, Hugo Marques
INTRODUCTION: White-coat hypertension (WCH) is a prevalent entity, which has been associated with an increased cardiovascular risk. AIM: Assess whether WCH is associated with a higher coronary atherosclerotic burden, evaluated by coronary computed tomography angiography (CCTA) and coronary artery calcium (CAC) scoring. METHODS: A total of 1362 patients who performed CCTA and simultaneous CAC for the assessment of coronary artery disease (CAD) were prospectively enrolled in a single-center registry and divided into three groups: (A) patients with normal blood pressure (BP) (n=386); (B) patients with WCH (n=174; without a history of hypertension or antihypertensive medication, but with systolic BP ≥140 and/or diastolic BP ≥90 mmHg before examination acquisition); and (C) patients with hypertension (n=802)...
August 30, 2016: Coronary Artery Disease
David G Rizik, James B Hermiller, Charles A Simonton, Kevin J Klassen, Dean J Kereiakes
Although current everolimus-eluting coronary stents have shown improved event-free survival within the first year following implantation compared with bare-metal stents or earlier generation drug-eluting stents, they remain associated with an ongoing risk for adverse outcomes (thrombosis, myocardial infarction, and restenosis) beyond 1 year at rates similar to those observed following bare-metal stent deployment. This ongoing very late hazard has been attributed to the permanent presence of the metal frame and/or polymer in these stents...
August 24, 2016: Coronary Artery Disease
Hesham K Abdelaziz, Wael Elkilany, Said Khalid, Sameh Sabet, Marwan Saad
OBJECTIVE: The aim of this study was to compare the role of intracoronary (IC) verapamil versus sodium nitroprusside (SNP) in the prevention of microvascular obstruction (MVO) during a primary percutaneous coronary intervention (pPCI). BACKGROUND: A head-to-head comparison between verapamil and SNP in the prevention of MVO lacks evidence. PATIENTS AND METHODS: Sixty patients with ST-segment elevation myocardial infarction were randomized to receive IC verapamil (n=30) versus SNP (n=30) during pPCI...
August 23, 2016: Coronary Artery Disease
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