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Coronary Artery Disease

Daniel A Jones, Krishnaraj S Rathod, Antonis N Pavlidis, Sean M Gallagher, Zoe Astroulakis, Pitt Lim, Alexander Sirker, Charles J Knight, Miles C Dalby, Iqbal S Malik, Anthony Mathur, Roby Rakhit, Simon Redwood, Philip A MacCarthy, Chris Baker, Ranil Desilva, Carlo Di Mario, Roshan Weerackody, Jonathan Hill, Andrew Wragg, Elliot J Smith
BACKGROUND: Chronic total occlusions (CTO) are commonly encountered in patients undergoing coronary angiography; however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a lack of randomized data. The aim of this study was to analyse the frequency and outcomes of CTO-PCI procedures in a large contemporary cohort of successive patients. PATIENTS AND METHODS: We undertook an observational cohort study of 48 234 patients with stable angina of which 5496 (11...
July 5, 2018: Coronary Artery Disease
Ryota Kakizaki, Yoshiyasu Minami, Takehiro Hashikata, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako
BACKGROUND: The aim of this study was to investigate whether the underlying plaque type affects the neointimal coverage after drug-eluting stent implantation. METHODS: A total of 1793 struts in 22 zotarolimus-eluting stents were assessed using optical coherence tomography imaging within 3 months of implantation. Neointimal coverage was evaluated within 5 mm from each stent edge on cross-sectional optical coherence tomography images at every 1-mm interval. The percentage of struts covered by neointima was compared among the normal segment group, the fibrous plaque group, and the lipid plaque group on the basis of the underlying plaque type...
July 2, 2018: Coronary Artery Disease
Alejandro Gutiérrez-Barrios, Dolores Cañadas-Pruaño, Teresa Bretones-Del Pino, Miguel Alba-Sánchez, Dolores Ruiz-Fernández, Germán Calle-Perez, Antonio Agarrado-Luna, Ricardo Zayas-Rueda, Ernesto Marante-Fuertes, Alberto Giráldez-Valpuesta, Jesús Oneto-Otero, Rafael Vázquez-García
BACKGROUND: Debate still remains on whether the presence of early recruited collateral circulation (ERCC) in the setting of an acute coronary occlusion (ACO) has a prognosis benefit. Some previous reports have shown lower mortality and morbidity rates in well-collateralized patients compared with those with poorly recruited collateral circulation (PCC), but others have not. In the primary angioplasty era, the role of collateral circulation in these studies may have been influenced by the effect of early reperfusion...
June 30, 2018: Coronary Artery Disease
Min Gyu Kang, Yoomee Kang, Hyun Gyung Jang, Kyehwan Kim, Jin-Sin Koh, Jeong Rang Park, Seok-Jae Hwang, Jin-Yong Hwang, Jae Seok Bae, Jong-Hwa Ahn, Jeong Yoon Jang, Yongwhi Park, Young-Hoon Jeong, Choong Hwan Kwak, Hyun Woong Park
BACKGROUND: This study aimed to evaluate whether the coronary artery calcium score (CACS) measured with computed tomography coronary angiography (CTCA) predicts periprocedural myocardial infarction (PMI) in patients undergoing an elective percutaneous coronary intervention (PCI). PATIENTS AND METHODS: A total of 197 patients with stable angina underwent elective PCI after CTCA. We evaluated CACS using CTCA and assessed the clinical risk factors for PMI. PMI was defined as an elevation of troponin I levels exceeding five times the upper limit of normal within 24 h after PCI...
June 29, 2018: Coronary Artery Disease
Hiroki Emori, Takashi Kubo, Takeyoshi Kameyama, Yasushi Ino, Yoshiki Matsuo, Hironori Kitabata, Kosei Terada, Yosuke Katayama, Akira Taruya, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
OBJECTIVE: Quantitative flow ratio (QFR) is a novel physiological index of the severity of coronary stenosis. The aim of the present study was to investigate the relationship between QFR and the instantaneous wave-free ratio (iFR). PATIENTS AND METHODS: We analyzed contrast-flow QFR, iFR, and fractional flow reserve (FFR) in 100 coronary arteries with intermediate stenosis. RESULTS: There was a high correlation (r=0.71, P<0.001) and a good agreement (mean difference: -0...
June 29, 2018: Coronary Artery Disease
Matthew W P Jackson, David Austin, Neil Swanson, Paul D Williams, Douglas F Muir, Jim A Hall, Robert A Wright, Andrew G C Sutton, Justin Carter, Mark A de Belder
BACKGROUND: The PRAMI and CvLPRIT trials support preventive percutaneous coronary intervention (PCI) for multivessel coronary disease found during ST-segment elevation myocardial infarction (STEMI). We assess our real-world experience of the management of multivessel disease identified during primary PCI (PPCI) in a large UK regional centre. PATIENTS AND METHODS: All STEMI patients who underwent culprit-only PPCI during the study period (August 2011 to August 2013) were retrospectively assessed for eligibility to each trial...
June 25, 2018: Coronary Artery Disease
Philip V M Linsen, Marcel J M Kofflard, Siu W Lam, Marc C J M Kock
No abstract text is available yet for this article.
June 19, 2018: Coronary Artery Disease
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
Evgeny Shkolnik, Greta Burneikaite, Gabrielius Jakutis, Mikhail Scherbak, Gitana Zuoziene, Birute Petrauskiene, Ekaterina Trush, Yury Vasyuk, Aleksandras Laucevicius, Jelena Celutkiene
BACKGROUND: Despite major advances in managing coronary artery disease and continuous research on alternative techniques to enhance myocardial perfusion and reduce symptoms, coronary artery disease is still one of the leading causes of adult disability worldwide. Cardiac shock-wave therapy (CSWT) has shown promising results in the amelioration of myocardial ischemia in experimental studies; however, clinical results are limited to single-center, mostly uncontrolled and underpowered trials...
June 16, 2018: Coronary Artery Disease
Tomasz Tokarek, Zbigniew Siudak, Artur Dziewierz, Tomasz Rakowski, Róża Krycińska, Andżelika Siwiec, Dariusz Dudek
BACKGROUND: Despite an increase in the proportion of nonagenarians in demographic structure, there is still a paucity of data on the utilization and outcome of percutaneous coronary interventions (PCIs) in this population. Also, very old patients are under-represented in randomized clinical trials and their treatment is still an emerging challenge. Thus, we sought to compare patient profiles and periprocedural outcomes of PCI in nonagenarians and patients younger than 90 years. PATIENTS AND METHODS: Data were based on the Polish National Registry of PCI (ORPKI)...
June 15, 2018: Coronary Artery Disease
Leor Perl, Véronique Peiffer, Audelia E Fuhrer, Fabrizio D'Ascenzo, Jan B Pietzsch
BACKGROUND: Despite advancements in treatment, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in the elderly population. Previous research has highlighted long-standing sex disparities in the care of these patients. However, differences in the patterns of discharge are not well described. One key parameter is the destination of discharge, and in particular - discharge to skilled nursing facilities (SNFs), a factor associated with worse prognosis and greater costs to the healthcare system...
June 6, 2018: Coronary Artery Disease
Masanao Naya, Yukari Uemura, Naoya Matsumoto, Mitsuru Momose, Takao Kato, Satoshi Hida, Takao Yamauchi, Takatomo Nakajima, Eriko Suzuki, Nagara Tamaki
BACKGROUND: The effects of initial tests on long-term events have been unknown. PATIENTS AND METHODS: In this observational retrospective study, we analyzed the effects of initial noninvasive tests by myocardial perfusion imaging (MPI) and computed tomography angiography (CTA) on long-term major adverse cardiac events (MACEs) among patients with suspected coronary artery disease during a median follow-up of 8.1 years (interquartile range: 7.7-8.9). RESULTS: Sex difference in the rate of abnormal findings on initial tests was observed in both the MPI (female vs...
June 5, 2018: Coronary Artery Disease
Takehisa Shimizu, Gary S Mintz, Bernard De Bruyne, Naim Z Farhat, Shinji Inaba, Yang Cao, Steven P Marso, Giora Weisz, Patrick W Serruys, Gregg W Stone, Akiko Maehara
OBJECTIVES: Whether the severity of left main coronary artery (LMCA) disease reflects LMCA and overall coronary atherosclerotic burden is not known. We aimed to assess nonculprit LMCA disease characteristics and the relationship with atherosclerosis in the rest of the coronary arteries as well as patient outcomes. PATIENTS AND METHODS: In the PROSPECT study, 697 patients with acute coronary syndromes underwent three-vessel gray-scale and radiofrequency intravascular ultrasound after percutaneous coronary intervention...
May 17, 2018: Coronary Artery Disease
Jelmer Westra, Niels R Holm, Evald H Christiansen, Troels Thim
No abstract text is available yet for this article.
May 14, 2018: Coronary Artery Disease
Kazuma Tashiro, Hiroyoshi Mori, Hiromoto Sone, Yousuke Takei, Masahiro Sasai, Atsuo Maeda, Tokutada Sato, Hiroshi Suzuki
No abstract text is available yet for this article.
May 9, 2018: Coronary Artery Disease
Yusaku Shibata, Nobuaki Kobayashi, Noritake Hata, Wataru Shimizu
No abstract text is available yet for this article.
May 8, 2018: Coronary Artery Disease
Yingzhong Lin, Yan Xue, Xinshun Huang, Jianyong Lu, Zicong Yang, Jing Ye, Shu Zhang, Ling Liu, Yu Liu, Ying Shi
OBJECTIVES: Inflammatory cytokines play an important role in the pathogenesis of cardiovascular disease. Few studies have investigated the association between interleukin-35 (IL-35) genetic variants and the risk of coronary heart disease (CHD). We examined the association between IL-35 polymorphisms and CHD in the Chinese Zhuang population. PATIENTS AND METHODS: A total of 707 CHD patients and 707 age-matched and sex-matched controls were enrolled in this case-control study...
May 5, 2018: Coronary Artery Disease
Hui Liu, Mingjun Zhang, Delong Li, Jingjing Tian, Xuyang Wang, Jinyu Pan, Dian Liu, Xiaowei Li, Fengshuang An
BACKGROUND: The aim of this study is to compare the efficacy and safety of pitavastatin and atorvastatin using data from randomized-controlled trial pooled together by means of a meta-analysis and decide which is better. METHODS: PubMed, CENTRAL, Web of Knowledge, and website were searched for randomized-controlled trials published until October 2016. Eligible studies comparing pitavastatin with atorvastatin head to head and reporting the outcome of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin, and intravascular ultrasound evaluation were enrolled...
May 5, 2018: Coronary Artery Disease
Laura Gatto, Marco Golino, Valeria Marco, Alessio La Manna, Francesco Burzotta, Massimo Fineschi, Giovanni Ruscica, Alessandro Di Giorgio, Alberto Boi, Enrico Romagnoli, Mario Albertucci, Francesco Prati
BACKGROUND: Quantitative coronary angiography (QCA) is the gold standard for evaluating correct stenting, despite its limitation in recognizing features indicative of suboptimal deployment. This subanalysis of the CLI-OPCI II registry addressed the role of optical coherence tomography (OCT) to verify whether suboptimal OCT deployment occurs in the presence of an optimal angiographic result. PATIENTS AND METHODS: We retrospectively analyzed 125 lesions in the 105 patients with major adverse cardiac events of the CLI-OPCI II...
April 24, 2018: Coronary Artery Disease
Ji Young Park, Byoung Geol Choi, Seung-Woon Rha, Tae Soo Kang, Cheol Ung Choi, Cheol Woong Yu, Hyeon-Cheol Gwon, In-Ho Chae, Hyo-Soo Kim, Hun Sik Park, Seung-Hwan Lee, Moo-Hyun Kim, Seung-Ho Hur, Yangsoo Jang
BACKGROUND: The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. PATIENTS AND METHODS: Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15%) patients underwent primary PCI because of AMI...
April 23, 2018: Coronary Artery Disease
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