Jakub Filipek, Katarzyna Chalaskiewicz, Aleksandra Kosmider, Maciej Nielipinski, Agnieszka Michalak, Maria Bednarkiewicz, Mieszko Goslawski-Zeligowski, Filip Prucnal, Bartosz Sekula, Agnieszka J Pietrzyk-Brzezinska
TetR family regulators (TFRs) represent a large group of one-component bacterial signal transduction systems which recognize environmental signals, like the presence of antibiotics or other bactericidal compounds, and trigger the cell response by regulating the expression of genes that secure bacterial survival in harsh environmental conditions. TFRs act as homodimers, each protomer is composed of a conserved DNA-binding N-terminal domain (NTD) and a variable ligand-binding C-terminal domain (CTD). Currently, there are about 500 structures of TFRs available in the Protein Data Bank and one-fourth of them represent the structures of TFR-ligand complexes...
February 22, 2024: Journal of Structural Biology